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Randolph Seth Watnick, Ph.D.

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  1. R01CA135417 (MITTAL, VIVEK) Feb 1, 2010 - Dec 31, 2015
    NIH
    Molecular mechanisms of tumor-initiated premetastatic niche formation in lung str
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 26 total Publications Show all
  1. Wang S, Zota V, Vincent MY, Clossey D, Chen JJ, Cieslewicz M, Watnick RS, Mahoney J, Watnick J. Assessing CD36 and CD47 expression levels in solid tumor indications to stratify patients for VT1021 treatment. NPJ Precis Oncol. 2024 Dec 03; 8(1):278. PMID: 39627379; PMCID: PMC11614903.
  2. Chen JJ, Vincent MY, Shepard D, Peereboom D, Mahalingam D, Battiste J, Patel MR, Juric D, Wen PY, Bullock A, Selfridge JE, Pant S, Liu J, Li W, Fyfe S, Wang S, Zota V, Mahoney J, Watnick RS, Cieslewicz M, Watnick J. Phase 1 dose expansion and biomarker study assessing first-in-class tumor microenvironment modulator VT1021 in patients with advanced solid tumors. Commun Med (Lond). 2024 May 21; 4(1):95. PMID: 38773224; PMCID: PMC11109328.
    Citations: 2 Article has an altmetric score of 4
  3. Mahalingam D, Harb W, Patnaik A, Bullock A, Watnick RS, Vincent MY, Chen JJ, Wang S, Pestana H, Chao J, Mahoney J, Cieslewicz M, Watnick J. First-in-human phase I dose escalation trial of the first-in-class tumor microenvironment modulator VT1021 in advanced solid tumors. Commun Med (Lond). 2024 Jan 13; 4(1):10. PMID: 38218979; PMCID: PMC10787778.
    Citations: 6 Article has an altmetric score of 3
  4. Sui L, Wang S, Ganguly D, El Rayes TP, Askeland C, Børretzen A, Sim D, Halvorsen OJ, Knutsvik G, Arnes J, Aziz S, Haukaas S, Foulkes WD, Bielenberg DR, Ziemys A, Mittal V, Brekken RA, Akslen LA, Watnick RS. PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nat Commun. 2022 12 27; 13(1):7959. PMID: 36575174; PMCID: PMC9794699.
    Citations: 4 Article has an altmetric score of 13
    Fields: BioBiologySciScienceTranslation:Humans
  5. Dao DT, Anez-Bustillos L, Jabbouri SS, Pan A, Kishikawa H, Mitchell PD, Fell GL, Baker MA, Watnick RS, Chen H, Rogers MS, Bielenberg DR, Puder M. A paradoxical method to enhance compensatory lung growth: Utilizing a VEGF inhibitor. PLoS One. 2018; 13(12):e0208579. PMID: 30566445; PMCID: PMC6300284.
    Citations: 2 Article has an altmetric score of 1
    Fields: MedMedicine (General)SciScienceTranslation:AnimalsCells
  6. Dao DT, Anez-Bustillos L, Ourieff J, Pan A, Mitchell PD, Kishikawa H, Fell GL, Baker MA, Watnick RS, Chen H, Hamilton TE, Rogers MS, Bielenberg DR, Puder M. Heparin impairs angiogenic signaling and compensatory lung growth after left pneumonectomy. Angiogenesis. 2018 11; 21(4):837-848. PMID: 29956017; PMCID: PMC6463887.
    Citations: 6
    Fields: HemHematologyTranslation:HumansAnimals
  7. Wang S, Blois A, El Rayes T, Liu JF, Hirsch MS, Gravdal K, Palakurthi S, Bielenberg DR, Akslen LA, Drapkin R, Mittal V, Watnick RS. Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment. Sci Transl Med. 2016 Mar 09; 8(329):329ra34. PMID: 26962158.
    Citations: 29
    Fields: MedMedicine (General)SciScienceTranslation:HumansAnimalsCells
  8. Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE, Battinelli EM. CCL5 derived from platelets increases megakaryocyte proplatelet formation. Blood. 2016 Feb 18; 127(7):921-6. PMID: 26647394; PMCID: PMC4760093.
    Citations: 50 Article has an altmetric score of 15
    Fields: HemHematologyTranslation:HumansAnimalsCells
  9. Watnick RS, Rodriguez RK, Wang S, Blois AL, Rangarajan A, Ince T, Weinberg RA. Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells. Oncogene. 2015 May 28; 34(22):2949-50. PMID: 26020734.
    Citations: 3
    Fields: MolMolecular BiologyNeoNeoplasms
  10. Adini I, Adini A, Bazinet L, Watnick RS, Bielenberg DR, D'Amato RJ. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB J. 2015 Feb; 29(2):662-70. PMID: 25406462; PMCID: PMC4314224.
    Citations: 10
    Fields: BioBiologyPhyPhysiologyTranslation:HumansAnimalsCells
  11. Watnick RS, Rodriguez RK, Wang S, Blois AL, Rangarajan A, Ince T, Weinberg RA. Thrombospondin-1 repression is mediated via distinct mechanisms in fibroblasts and epithelial cells. Oncogene. 2015 May 28; 34(22):2823-35. PMID: 25109329.
    Citations: 14
    Fields: MolMolecular BiologyNeoNeoplasmsTranslation:HumansCells
  12. Rogers MS, Novak K, Zurakowski D, Cryan LM, Blois A, Lifshits E, Bø TH, Oyan AM, Bender ER, Lampa M, Kang SY, Naxerova K, Kalland KH, Straume O, Akslen LA, Watnick RS, Folkman J, Naumov GN. Spontaneous reversion of the angiogenic phenotype to a nonangiogenic and dormant state in human tumors. Mol Cancer Res. 2014 May; 12(5):754-64. PMID: 24574516.
    Citations: 5
    Fields: CelCell BiologyMolMolecular BiologyNeoNeoplasmsTranslation:HumansAnimalsCells
  13. Li W, Ai N, Wang S, Bhattacharya N, Vrbanac V, Collins M, Signoretti S, Hu Y, Boyce FM, Gravdal K, Halvorsen OJ, Nalwoga H, Akslen LA, Harlow E, Watnick RS. GRK3 is essential for metastatic cells and promotes prostate tumor progression. Proc Natl Acad Sci U S A. 2014 Jan 28; 111(4):1521-6. PMID: 24434559; PMCID: PMC3910602.
    Citations: 29 Article has an altmetric score of 6
    Fields: SciScienceTranslation:Humans
  14. Catena R, Bhattacharya N, El Rayes T, Wang S, Choi H, Gao D, Ryu S, Joshi N, Bielenberg D, Lee SB, Haukaas SA, Gravdal K, Halvorsen OJ, Akslen LA, Watnick RS, Mittal V. Bone marrow-derived Gr1+ cells can generate a metastasis-resistant microenvironment via induced secretion of thrombospondin-1. Cancer Discov. 2013 May; 3(5):578-89. PMID: 23633432.
    Citations: 74
    Fields: NeoNeoplasmsTranslation:HumansAnimalsCells
  15. Retraction. Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell. 2013 Jan 14; 23(1):129. PMID: 23447819.
    Citations: Article has an altmetric score of 22
    Fields: NeoNeoplasms
  16. Watnick RS. The role of the tumor microenvironment in regulating angiogenesis. Cold Spring Harb Perspect Med. 2012 Dec 01; 2(12):a006676. PMID: 23209177; PMCID: PMC3543072.
    Citations: 70
    Fields: MedMedicine (General)Translation:HumansCells
  17. Straume O, Shimamura T, Lampa MJ, Carretero J, Øyan AM, Jia D, Borgman CL, Soucheray M, Downing SR, Short SM, Kang SY, Wang S, Chen L, Collett K, Bachmann I, Wong KK, Shapiro GI, Kalland KH, Folkman J, Watnick RS, Akslen LA, Naumov GN. Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8699-704. PMID: 22589302.
    Citations: 66
    Fields: SciScienceTranslation:HumansAnimalsCells
  18. Kang SY, Halvorsen OJ, Gravdal K, Bhattacharya N, Lee JM, Liu NW, Johnston BT, Johnston AB, Haukaas SA, Aamodt K, Yoo S, Akslen LA, Watnick RS. Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):12115-20. PMID: 19581582; PMCID: PMC2715504.
    Citations: 54 Article has an altmetric score of 19
    Fields: SciScienceTranslation:HumansAnimalsCells
  19. Godar S, Ince TA, Bell GW, Feldser D, Donaher JL, Bergh J, Liu A, Miu K, Watnick RS, Reinhardt F, McAllister SS, Jacks T, Weinberg RA. Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell. 2008 Jul 11; 134(1):62-73. PMID: 18614011; PMCID: PMC3222460.
    Citations: 241 Article has an altmetric score of 6
    Fields: CelCell BiologyTranslation:HumansAnimalsCells
  20. Kang SY, Watnick RS. Regulation of tumor dormancy as a function of tumor-mediated paracrine regulation of stromal Tsp-1 and VEGF expression. APMIS. 2008 Jul-Aug; 116(7-8):638-47. PMID: 18834408.
    Citations: 7
    Fields: AllAllergy and ImmunologyMicMicrobiologyPatPathologyTranslation:Humans
  21. Naumov GN, Bender E, Zurakowski D, Kang SY, Sampson D, Flynn E, Watnick RS, Straume O, Akslen LA, Folkman J, Almog N. A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype. J Natl Cancer Inst. 2006 Mar 01; 98(5):316-25. PMID: 16507828.
    Citations: 160 Article has an altmetric score of 6
    Fields: NeoNeoplasmsTranslation:HumansAnimalsCells
  22. Cerimele F, Battle T, Lynch R, Frank DA, Murad E, Cohen C, Macaron N, Sixbey J, Smith K, Watnick RS, Eliopoulos A, Shehata B, Arbiser JL. Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):175-9. PMID: 15611471; PMCID: PMC544042.
    Citations: 65 Article has an altmetric score of 3
    Fields: SciScienceTranslation:HumansCells
  23. Watnick RS, Cheng YN, Rangarajan A, Ince TA, Weinberg RA. Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell. 2003 Mar; 3(3):219-31. PMID: 12676581.
    Citations: 109 Article has an altmetric score of 13
    Fields: NeoNeoplasmsTranslation:HumansCells
  24. Watnick RS, Herring SC, Palmer AG, Gottesman ME. The carboxyl terminus of phage HK022 Nun includes a novel zinc-binding motif and a tryptophan required for transcription termination. Genes Dev. 2000 Mar 15; 14(6):731-9. PMID: 10733532; PMCID: PMC316458.
    Citations: 6
    Fields: MolMolecular BiologyTranslation:Cells
  25. Watnick RS, Gottesman ME. Binding of transcription termination protein nun to nascent RNA and template DNA. Science. 1999 Dec 17; 286(5448):2337-9. PMID: 10600743.
    Citations: 12
    Fields: SciScienceTranslation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.