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Last Name

profileRonald Charles Desrosiers, Ph.D.

TitleProfessor of Microbiology and Immunobiology, Emeritus
InstitutionHarvard Medical School
AddressN.E. Reg. Primate Research Ctr
1 Pine Hill Dr
Southborough MA 01772
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AI104523     (DESROSIERS, RONALD C)Feb 15, 2013 - Jan 31, 2018
Functional Role of O-Glycosylation of HIV-1
Role: Principal Investigator

R01AI098446     (DESROSIERS, RONALD C)Jul 18, 2012 - Nov 30, 2021
Immunoglobulins Delivered by AVV Vector for the Prevention of SIV Infection
Role: Principal Investigator

P01AI100263     (FARZAN, MICHAEL R.)Apr 1, 2012 - Mar 31, 2017
A Gene therapeutic approach to stable suppression of HIV-1 replication
Role: Co-Principal Investigator

U19AI095985     (BAROUCH, DAN H.)Jul 15, 2011 - Jun 30, 2016
Consortium for AIDS Vaccine Research in Nonhuman Primates
Role: Co-Principal Investigator

R01AI072004     (DESROSIERS, RONALD C)Mar 1, 2008 - Feb 28, 2013
Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and Neutralization
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Magnani DM, Silveira CGT, Ricciardi MJ, Gonzalez-Nieto L, Pedreño-Lopez N, Bailey VK, Gutman MJ, Maxwell HS, Domingues A, Costa PR, Ferrari L, Goulart R, Martins MA, Martinez-Navio JM, Fuchs SP, Kalil J, Timenetsky MDC, Wrammert J, Whitehead SS, Burton DR, Desrosiers RC, Kallas EG, Watkins DI. Potent Plasmablast-Derived Antibodies Elicited by the National Institutes of Health Dengue Vaccine. J Virol. 2017 Nov 15; 91(22). PMID: 28878078.
    View in: PubMed
  2. Magnani DM, Rogers TF, Beutler N, Ricciardi MJ, Bailey VK, Gonzalez-Nieto L, Briney B, Sok D, Le K, Strubel A, Gutman MJ, Pedreño-Lopez N, Grubaugh ND, Silveira CGT, Maxwell HS, Domingues A, Martins MA, Lee DE, Okwuazi EE, Jean S, Strobert EA, Chahroudi A, Silvestri G, Vanderford TH, Kallas EG, Desrosiers RC, Bonaldo MC, Whitehead SS, Burton DR, Watkins DI. Neutralizing human monoclonal antibodies prevent Zika virus infection in macaques. Sci Transl Med. 2017 Oct 04; 9(410). PMID: 28978754.
    View in: PubMed
  3. Termini JM, Magnani DM, Maxwell HS, Lauer W, Castro I, Pecotte J, Barber GN, Watkins DI, Desrosiers RC. Simian T Lymphotropic Virus 1 Infection of Papio anubis: tax Sequence Heterogeneity and T Cell Recognition. J Virol. 2017 Oct 15; 91(20). PMID: 28724769.
    View in: PubMed
  4. Termini JM, Church ES, Silver ZA, Haslam SM, Dell A, Desrosiers RC. Human Immunodeficiency Virus and Simian Immunodeficiency Virus Maintain High Levels of Infectivity in the Complete Absence of Mucin-Type O-Glycosylation. J Virol. 2017 Oct 01; 91(19). PMID: 28747495.
    View in: PubMed
  5. Desrosiers RC. Protection against HIV Acquisition in the RV144 Trial. J Virol. 2017 Sep 15; 91(18). PMID: 28701398.
    View in: PubMed
  6. Postler TS, Pantry SN, Desrosiers RC, Ghosh S. Identification and characterization of a long non-coding RNA up-regulated during HIV-1 infection. Virology. 2017 Nov; 511:30-39. PMID: 28803142.
    View in: PubMed
  7. Bischof GF, Magnani DM, Ricciardi M, Shin YC, Domingues A, Bailey VK, Gonzalez-Nieto L, Rakasz EG, Watkins DI, Desrosiers RC. Use of a Recombinant Gamma-2 Herpesvirus Vaccine Vector against Dengue Virus in Rhesus Monkeys. J Virol. 2017 Aug 15; 91(16). PMID: 28592531.
    View in: PubMed
  8. Magnani DM, Ricciardi MJ, Bailey VK, Gutman MJ, Pedreño-Lopez N, Silveira CGT, Maxwell HS, Domingues A, Gonzalez-Nieto L, Su Q, Newman RM, Pack M, Martins MA, Martinez-Navio JM, Fuchs SP, Rakasz EG, Allen TM, Whitehead SS, Burton DR, Gao G, Desrosiers RC, Kallas EG, Watkins DI. Dengue Virus Evades AAV-Mediated Neutralizing Antibody Prophylaxis in Rhesus Monkeys. Mol Ther. 2017 Oct 04; 25(10):2323-2331. PMID: 28750738.
    View in: PubMed
  9. Martins MA, Shin YC, Gonzalez-Nieto L, Domingues A, Gutman MJ, Maxwell HS, Castro I, Magnani DM, Ricciardi M, Pedreño-Lopez N, Bailey V, Betancourt D, Altman JD, Pauthner M, Burton DR, von Bredow B, Evans DT, Yuan M, Parks CL, Ejima K, Allison DB, Rakasz E, Barber GN, Capuano S, Lifson JD, Desrosiers RC, Watkins DI. Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques. PLoS Pathog. 2017 Jul; 13(7):e1006529. PMID: 28732035.
    View in: PubMed
  10. Bischof GF, Shin YC, Fuchs SP, Martinez-Navio JM, Lauer WA, Rakasz EG, Desrosiers RC. Use of a gamma-2 herpesvirus as a vector to deliver antibodies to rhesus monkeys. Gene Ther. 2017 Aug; 24(8):487-492. PMID: 28660888.
    View in: PubMed
  11. Martins MA, Tully DC, Shin YC, Gonzalez-Nieto L, Weisgrau KL, Bean DJ, Gadgil R, Gutman MJ, Domingues A, Maxwell HS, Magnani DM, Ricciardi M, Pedreño-Lopez N, Bailey V, Cruz MA, Lima NS, Bonaldo MC, Altman JD, Rakasz E, Capuano S, Reimann KA, Piatak M, Lifson JD, Desrosiers RC, Allen TM, Watkins DI. Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque. AIDS Res Hum Retroviruses. 2017 Aug; 33(8):843-858. PMID: 28503929.
    View in: PubMed
  12. Termini JM, Silver ZA, Connor B, Antonopoulos A, Haslam SM, Dell A, Desrosiers RC. HEK293T cell lines defective for O-linked glycosylation. PLoS One. 2017; 12(6):e0179949. PMID: 28654657.
    View in: PubMed
  13. Magnani DM, Silveira CGT, Rosen BC, Ricciardi MJ, Pedreño-Lopez N, Gutman MJ, Bailey VK, Maxwell HS, Domingues A, Gonzalez-Nieto L, Avelino-Silva VI, Trindade M, Nogueira J, Oliveira CS, Maestri A, Felix AC, Levi JE, Nogueira ML, Martins MA, Martinez-Navio JM, Fuchs SP, Whitehead SS, Burton DR, Desrosiers RC, Kallas EG, Watkins DI. A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus. PLoS Negl Trop Dis. 2017 Jun; 11(6):e0005655. PMID: 28604797.
    View in: PubMed
  14. Adnan S, Reeves RK, Gillis J, Wong FE, Yu Y, Camp JV, Li Q, Connole M, Li Y, Piatak M, Lifson JD, Li W, Keele BF, Kozlowski PA, Desrosiers RC, Haase AT, Johnson RP. Persistent Low-Level Replication of SIV?nef Drives Maturation of Antibody and CD8 T Cell Responses to Induce Protective Immunity against Vaginal SIV Infection. PLoS Pathog. 2016 Dec; 12(12):e1006104. PMID: 27959961.
    View in: PubMed
  15. Fuchs SP, Desrosiers RC. Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies. Mol Ther Methods Clin Dev. 2016; 3:16068. PMID: 28197421.
    View in: PubMed
  16. Keating SM, Heitman JW, Wu S, Deng X, Stacey AR, Zahn RC, de la Rosa M, Finstad SL, Lifson JD, Piatak M, Gauduin MC, Kessler BM, Ternette N, Carville A, Johnson RP, Desrosiers RC, Letvin NL, Borrow P, Norris PJ, Schmitz JE. Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates. J Virol. 2016 Nov 15; 90(22):10339-10350. PMID: 27630228.
    View in: PubMed
  17. Panico M, Bouché L, Binet D, O'Connor MJ, Rahman D, Pang PC, Canis K, North SJ, Desrosiers RC, Chertova E, Keele BF, Bess JW, Lifson JD, Haslam SM, Dell A, Morris HR. Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding. Sci Rep. 2016 Sep 08; 6:32956. PMID: 27604319; PMCID: PMC5015092.
  18. Fuchs SP, Martinez-Navio JM, Gao G, Desrosiers RC. Recombinant AAV Vectors for Enhanced Expression of Authentic IgG. PLoS One. 2016; 11(6):e0158009. PMID: 27332822; PMCID: PMC4917256.
  19. Castro I, Giret TM, Magnani DM, Maxwell HS, Umland O, Perry JK, Pecotte JK, Brasky KM, Barber GN, Desrosiers RC, Watkins DI. Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons. J Virol. 2016 Jun 01; 90(11):5280-91. PMID: 26984729; PMCID: PMC4934758 [Available on 11/12/16].
  20. Shin YC, Bischof GF, Lauer WA, Desrosiers RC. Importance of codon usage for the temporal regulation of viral gene expression. Proc Natl Acad Sci U S A. 2015 Nov 10; 112(45):14030-5. PMID: 26504241; PMCID: PMC4653223.
  21. Martinez-Navio JM, Fuchs SP, Pedreño-López S, Rakasz EG, Gao G, Desrosiers RC. Host Anti-antibody Responses Following Adeno-associated Virus-mediated Delivery of Antibodies Against HIV and SIV in Rhesus Monkeys. Mol Ther. 2016 Feb; 24(1):76-86. PMID: 26444083; PMCID: PMC4754551 [Available on 02/01/17].
  22. Fuchs SP, Martinez-Navio JM, Piatak M, Lifson JD, Gao G, Desrosiers RC. AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity. PLoS Pathog. 2015 Aug; 11(8):e1005090. PMID: 26248318; PMCID: PMC4527674.
  23. Stansell E, Panico M, Canis K, Pang PC, Bouché L, Binet D, O'Connor MJ, Chertova E, Bess J, Lifson JD, Haslam SM, Morris HR, Desrosiers RC, Dell A. Gp120 on HIV-1 Virions Lacks O-Linked Carbohydrate. PLoS One. 2015; 10(4):e0124784. PMID: 25915761; PMCID: PMC4410959.
  24. Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M. AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges. Nature. 2015 Mar 05; 519(7541):87-91. PMID: 25707797; PMCID: PMC4352131.
  25. Postler TS, Bixby JG, Desrosiers RC, Yuste E. Systematic analysis of intracellular trafficking motifs located within the cytoplasmic domain of simian immunodeficiency virus glycoprotein gp41. PLoS One. 2014; 9(12):e114753. PMID: 25479017; PMCID: PMC4257708.
  26. Desrosiers RC, Hahn AS. Reply to "On the use of 2,5-dimethyl-pyrrol-1-yl-benzoic acid derivatives as EPH-ephrin antagonists". J Virol. 2014 Oct; 88(20):12174. PMID: 25246599; PMCID: PMC4178713.
  27. Yang GB, Alexander L, Aye P, Alvarez X, Desrosiers RC, Lackner AA. Localization of productively infected cells in the spleen and Peyer's patches of rhesus macaques during acute infection with SIVmac239?nef-enhanced green fluorescent protein. AIDS Res Hum Retroviruses. 2014 Aug; 30(8):738-9. PMID: 25026557; PMCID: PMC4118711.
  28. Hahn AS, Desrosiers RC. Binding of the Kaposi's sarcoma-associated herpesvirus to the ephrin binding surface of the EphA2 receptor and its inhibition by a small molecule. J Virol. 2014 Aug; 88(16):8724-34. PMID: 24899181; PMCID: PMC4136269.
  29. Yen PJ, Mefford ME, Hoxie JA, Williams KC, Desrosiers RC, Gabuzda D. Identification and characterization of a macrophage-tropic SIV envelope glycoprotein variant in blood from early infection in SIVmac251-infected macaques. Virology. 2014 Jun; 458-459:53-68. PMID: 24928039; PMCID: PMC4112485.
  30. Yang B, Li S, Wang H, Guo Y, Gessler DJ, Cao C, Su Q, Kramer J, Zhong L, Ahmed SS, Zhang H, He R, Desrosiers RC, Brown R, Xu Z, Gao G. Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10. Mol Ther. 2014 Jul; 22(7):1299-1309. PMID: 24781136; PMCID: PMC4089005.
  31. Westmoreland SV, Converse AP, Hrecka K, Hurley M, Knight H, Piatak M, Lifson J, Mansfield KG, Skowronski J, Desrosiers RC. SIV vpx is essential for macrophage infection but not for development of AIDS. PLoS One. 2014; 9(1):e84463. PMID: 24465411; PMCID: PMC3897363.
  32. Hahn AS, Desrosiers RC. Rhesus monkey rhadinovirus uses eph family receptors for entry into B cells and endothelial cells but not fibroblasts. PLoS Pathog. 2013; 9(5):e1003360. PMID: 23696734; PMCID: PMC3656109.
  33. Manrique J, Piatak M, Lauer W, Johnson W, Mansfield K, Lifson J, Desrosiers R. Influence of mismatch of Env sequences on vaccine protection by live attenuated simian immunodeficiency virus. J Virol. 2013 Jul; 87(13):7246-54. PMID: 23637396; PMCID: PMC3700272.
  34. Del Prete GQ, Scarlotta M, Newman L, Reid C, Parodi LM, Roser JD, Oswald K, Marx PA, Miller CJ, Desrosiers RC, Barouch DH, Pal R, Piatak M, Chertova E, Giavedoni LD, O'Connor DH, Lifson JD, Keele BF. Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies. J Virol. 2013 Apr; 87(8):4584-95. PMID: 23408608; PMCID: PMC3624367.
  35. Postler TS, Desrosiers RC. The tale of the long tail: the cytoplasmic domain of HIV-1 gp41. J Virol. 2013 Jan; 87(1):2-15. PMID: 23077317; PMCID: PMC3536369.
  36. Martinez-Navio JM, Desrosiers RC. Neutralizing capacity of monoclonal antibodies that recognize peptide sequences underlying the carbohydrates on gp41 of simian immunodeficiency virus. J Virol. 2012 Dec; 86(23):12484-93. PMID: 22993152; PMCID: PMC3497684.
  37. Alpert MD, Harvey JD, Lauer WA, Reeves RK, Piatak M, Carville A, Mansfield KG, Lifson JD, Li W, Desrosiers RC, Johnson RP, Evans DT. ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge. PLoS Pathog. 2012; 8(8):e1002890. PMID: 22927823; PMCID: PMC3426556.
  38. Postler TS, Desrosiers RC. The cytoplasmic domain of the HIV-1 glycoprotein gp41 induces NF-?B activation through TGF-ß-activated kinase 1. Cell Host Microbe. 2012 Feb 16; 11(2):181-93. PMID: 22341466; PMCID: PMC3285415.
  39. Postler TS, Martinez-Navio JM, Yuste E, Desrosiers RC. Evidence against extracellular exposure of a highly immunogenic region in the C-terminal domain of the simian immunodeficiency virus gp41 transmembrane protein. J Virol. 2012 Jan; 86(2):1145-57. PMID: 22072749; PMCID: PMC3255797.
  40. Hollingsworth MT, Hart GW, Paulson JC, Stansell E, Canis K, Huang IC, Panico M, Morris H, Haslam S, Farzan M, Dell A, Desrosiers R, von Itzstein M, Matroscovich M, Luther KB, Hülsmeier AJ, Schegg B, Hennet T, Nycholat C, McBride R, Ekiert D, Xu R, Peng W, Razi N, Gilbert M, Wakarchuk W, Wilson IA, Paulson JC, Gahlay G, Geisler C, Aumiller JJ, Moremen K, Steel J, Labaer J, Jarvis DL, Drickamer K, Taylor M, Nizet V, Rabinovich G, Lewis C, Cobb B, Kawasaki N, Nycholat C, Rademacher C, Chen W, Vela J, Maricic I, Crocker P, Kumar V, Kronenberg M, Paulson J, Glenn K, Mallinger A, Wen H, Srivastava L, Tundup S, Harn D, Menon AK, Yamaguchi Y, Mkhikian H, Grigorian A, Li C, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, Dennis JW, Demetriou M, Pandey MS, Baggenstoss BA, Washburn JL, Weigel PH, Chen CI, Keusch JJ, Klein D, Hofsteenge J, Gut H, Szymanski C, Feldman M, Schaffer C, Gao Y, Strum S, Liu B, Schutzbach JS, Druzhinina TN, Utkina NS, Torgov VI, Szarek WA, Wang L, Brockhausen I, Hitchen P, Peyfoon E, Meyer B, Haslam S, Albers SV, Dell A, Yu Z, Chen C, Liu B, Newburg DS, Jin C, Dinglasan RD, Beverley SM, Guo H, Novozhilova N, Hickerson S, Elnaiem DE, Sacks D, Turco SJ, McKay D, Castro E, Takahashi H, Straus AH, Stalnaker SH, Live D, Boons GJ, Moremen K, Wells L, Stuart R, Aoki K, Boccuto L, Zhang Q, Wang H, Bartel F, Fan X, Saul R, Chaubey A, Yang X, Steet R, Schwartz C, Tiemeyer M, Pierce M, Kraushaar DC, Condac E, Yamaguchi Y, Wang L, Nakato H, Nishihara S, Sasaki N, Hirano K, Nasirikenari M, Collins CC, Lau JT, Devarapu SK, Jeyaweerasinkam S, Albiez RS, Kiessling L, Gu J, Clark GF, Gagneux P, Ulm C, Mahavadi P, Müller S, Rinné S, Geyer H, Gerardy-Schahn R, Mühlenhoff M, Günther A, Geyer R, Galuska SP, Shibata T, Sugihara K, Nakayama J, Fukuda M, Fukuda MN, Ishikawa A, Terao M, Kimura A, Kato A, Katayama I, Taniguchi N, Miyoshi E, Aderem A, Yoneyama T, Angata K, Bao X, Chanda S, Fukuda M, Boons GJ, Lowe J, Sonon R, Ishihara M, Talabnin K, Wang Z, Black I, Naran R, Heiss C, Azadi P, Hurum D, Rohrer J, Balland A, Valliere-Douglass J, Kodama P, Mujacic M, Eakin C, Brady L, Wang WC, Wallace A, Treuheit M, Reddy P, Schuman B, Fisher S, Borisova S, Coates L, Langan P, Evans S, Yang SJ, Zhang H, Hizal DB, Tian Y, Sarkaria V, Betenbaugh M, Zhang H, Lütteke T, Agravat S, Cholleti S, Morris T, Saltz J, Song X, Cummings R, Smith D, Hofhine T, Nishida C, Mialy R, Sophie D, Sebastien F, Patricia C, Eric S, Stephane H, Mokros D, Joosten RP, Dominik A, Vriend G, Lütteke T, Nguyen LD, Martinez J, Hinderlich S, Reissig HU, Reutter W, Fan H, Saenger W, Moniot S, Asada H, Nakahara T, Miura Y, Stevenson T, Yamazaki T, De Castro C, Burr T, Lanzetta R, Molinaro A, Parrilli M, Sule S, Gerken TA, Revpredo L, Thome J, Gerken TA, Cardenas G, Almeida I, Leung MY, Yan S, Paschinger K, Bleuler-Martinez S, Jantsch V, Wilson I, Yoshimura Y, Adlercreutz D, Mannerstedt K, Wakarchuk WW, Dovichi NJ, Hindsgaul O, Palcic MM, Chandrasekaran A, Bharadwaj R, Deng K, Adams P, Singh A, Datta A, Konasani V, Imamura A, Lowry T, Scaman C, Zhao Y, Zhou YD, Yang K, Zhang XL, Leymarie N, Hartshorn K, White M, Cafarella T, Seaton B, Rynkiewicz M, Zaia J, Acosta-Blanco I, Ortega-Francisco S, Dionisio-Vicuña M, Hernandez-Flores M, Fuentes-Romero L, Newburg D, Soto-Ramirez LE, Ruiz-Palacios G, Viveros-Rogel M, Tong C, Li W, Kong L, Qu M, Jin Q, Lukyanov P, Li W, Tong C, Zhang W, Qu M, Jin Q, Chicalovets I, Molchanova V, Lukyanov P, Wu AM, Liu JH, Yang WH, Nussbaum C, Grewal PK, Sperandio M, Marth JD, Yu R, Usuki S, Wu HC, O'Brien D, Piskarev V, Ramadugu SK, Kashyap HK, Ghirlanda G, Margulis C, Brewer C, Gomery K, Müller-Loennies S, Brooks CL, Brade L, Kosma P, Di Padova F, Brade H, Evans SV, Asakawa K, Kawakami K, Kushi Y, Suzuki Y, Nozaki H, Itonori S, Malik S, Lebeer S, Petrova M, Balzarini J, Vanderleyden J, Naito-Matsui Y, Takematsu H, Murata K, Kozutsumi Y, Subedi GP, Satoh T, Hanashima S, et al. Program and abstracts for the 2011 Meeting of the Society for Glycobiology. Glycobiology. 2011 Nov; 21(11):1454-531. PMID: 21994331.
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  41. Bilello JP, Manrique JM, Shin YC, Lauer W, Li W, Lifson JD, Mansfield KG, Johnson RP, Desrosiers RC. Vaccine protection against simian immunodeficiency virus in monkeys using recombinant gamma-2 herpesvirus. J Virol. 2011 Dec; 85(23):12708-20. PMID: 21900170; PMCID: PMC3209374.
  42. Shin YC, Desrosiers RC. Rhesus monkey rhadinovirus ORF57 induces gH and gL glycoprotein expression through posttranscriptional accumulation of target mRNAs. J Virol. 2011 Aug; 85(15):7810-7. PMID: 21613403; PMCID: PMC3147903.
  43. Stansell E, Desrosiers RC. Functional contributions of carbohydrate on AIDS virus glycoprotein. Yale J Biol Med. 2010 Dec; 83(4):201-8. PMID: 21165339; PMCID: PMC3002149.
  44. Stansell E, Canis K, Haslam SM, Dell A, Desrosiers RC. Simian immunodeficiency virus from the sooty mangabey and rhesus macaque is modified with O-linked carbohydrate. J Virol. 2011 Jan; 85(1):582-95. PMID: 20962077; PMCID: PMC3014205.
  45. Bixby JG, Laur O, Johnson WE, Desrosiers RC. Diversity of envelope genes from an uncloned stock of SIVmac251. AIDS Res Hum Retroviruses. 2010 Oct; 26(10):1115-31. PMID: 20836705; PMCID: PMC2982722.
  46. Stansell E, Desrosiers RC. Fundamental difference in the content of high-mannose carbohydrate in the HIV-1 and HIV-2 lineages. J Virol. 2010 Sep; 84(18):8998-9009. PMID: 20610711; PMCID: PMC2937622.
  47. O'Connor SL, Lhost JJ, Becker EA, Detmer AM, Johnson RC, Macnair CE, Wiseman RW, Karl JA, Greene JM, Burwitz BJ, Bimber BN, Lank SM, Tuscher JJ, Mee ET, Rose NJ, Desrosiers RC, Hughes AL, Friedrich TC, Carrington M, O'Connor DH. MHC heterozygote advantage in simian immunodeficiency virus-infected Mauritian cynomolgus macaques. Sci Transl Med. 2010 Mar 10; 2(22):22ra18. PMID: 20375000; PMCID: PMC2865159.
  48. Shin YC, Jones LR, Manrique J, Lauer W, Carville A, Mansfield KG, Desrosiers RC. Glycoprotein gene sequence variation in rhesus monkey rhadinovirus. Virology. 2010 May 10; 400(2):175-86. PMID: 20172576; PMCID: PMC2852144.
  49. Johnson PR, Schnepp BC, Zhang J, Connell MJ, Greene SM, Yuste E, Desrosiers RC, Clark KR. Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys. Nat Med. 2009 Aug; 15(8):901-6. PMID: 19448633; PMCID: PMC2723177.
  50. Yuste E, Bixby J, Lifson J, Sato S, Johnson W, Desrosiers R. Glycosylation of gp41 of simian immunodeficiency virus shields epitopes that can be targets for neutralizing antibodies. J Virol. 2008 Dec; 82(24):12472-86. PMID: 18829751; PMCID: PMC2593353.
  51. Laird ME, Igarashi T, Martin MA, Desrosiers RC. Importance of the V1/V2 loop region of simian-human immunodeficiency virus envelope glycoprotein gp120 in determining the strain specificity of the neutralizing antibody response. J Virol. 2008 Nov; 82(22):11054-65. PMID: 18768967; PMCID: PMC2573292.
  52. Morgan C, Marthas M, Miller C, Duerr A, Cheng-Mayer C, Desrosiers R, Flores J, Haigwood N, Hu SL, Johnson RP, Lifson J, Montefiori D, Moore J, Robert-Guroff M, Robinson H, Self S, Corey L. The use of nonhuman primate models in HIV vaccine development. PLoS Med. 2008 Aug 12; 5(8):e173. PMID: 18700814; PMCID: PMC2504486.
  53. Sato S, Yuste E, Lauer WA, Chang EH, Morgan JS, Bixby JG, Lifson JD, Desrosiers RC, Johnson WE. Potent antibody-mediated neutralization and evolution of antigenic escape variants of simian immunodeficiency virus strain SIVmac239 in vivo. J Virol. 2008 Oct; 82(19):9739-52. PMID: 18667507; PMCID: PMC2546989.
  54. Bilello JP, Morgan JS, Desrosiers RC. Extreme dependence of gH and gL expression on ORF57 and association with highly unusual codon usage in rhesus monkey rhadinovirus. J Virol. 2008 Jul; 82(14):7231-7. PMID: 18480451; PMCID: PMC2446953.
  55. Mansfield K, Lang SM, Gauduin MC, Sanford HB, Lifson JD, Johnson RP, Desrosiers RC. Vaccine protection by live, attenuated simian immunodeficiency virus in the absence of high-titer antibody responses and high-frequency cellular immune responses measurable in the periphery. J Virol. 2008 Apr; 82(8):4135-48. PMID: 18272584; PMCID: PMC2292994.
  56. Laird ME, Desrosiers RC. Infectivity and neutralization of simian immunodeficiency virus with FLAG epitope insertion in gp120 variable loops. J Virol. 2007 Oct; 81(20):10838-48. PMID: 17686865; PMCID: PMC2045528.
  57. Marzi A, Mitchell DA, Chaipan C, Fisch T, Doms RW, Carrington M, Desrosiers RC, Pöhlmann S. Modulation of HIV and SIV neutralization sensitivity by DC-SIGN and mannose-binding lectin. Virology. 2007 Nov 25; 368(2):322-30. PMID: 17659761.
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  58. Schäfer A, Cai X, Bilello JP, Desrosiers RC, Cullen BR. Cloning and analysis of microRNAs encoded by the primate gamma-herpesvirus rhesus monkey rhadinovirus. Virology. 2007 Jul 20; 364(1):21-7. PMID: 17451774; PMCID: PMC1941761.
  59. Beddows S, Franti M, Dey AK, Kirschner M, Iyer SP, Fisch DC, Ketas T, Yuste E, Desrosiers RC, Klasse PJ, Maddon PJ, Olson WC, Moore JP. A comparative immunogenicity study in rabbits of disulfide-stabilized, proteolytically cleaved, soluble trimeric human immunodeficiency virus type 1 gp140, trimeric cleavage-defective gp140 and monomeric gp120. Virology. 2007 Apr 10; 360(2):329-40. PMID: 17126869.
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  78. Borda JT, Alvarez X, Kondova I, Aye P, Simon MA, Desrosiers RC, Lackner AA. Cell tropism of simian immunodeficiency virus in culture is not predictive of in vivo tropism or pathogenesis. Am J Pathol. 2004 Dec; 165(6):2111-22. PMID: 15579453; PMCID: PMC1618703.
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  93. Allen TM, Jing P, Calore B, Horton H, O'Connor DH, Hanke T, Piekarczyk M, Ruddersdorf R, Mothé BR, Emerson C, Wilson N, Lifson JD, Belyakov IM, Berzofsky JA, Wang C, Allison DB, Montefiori DC, Desrosiers RC, Wolinsky S, Kunstman KJ, Altman JD, Sette A, McMichael AJ, Watkins DI. Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection. J Virol. 2002 Oct; 76(20):10507-11. PMID: 12239328; PMCID: PMC136573.
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  146. Sasseville VG, Rottman JB, Du Z, Veazey R, Knight HL, Caunt D, Desrosiers RC, Lackner AA. Characterization of the cutaneous exanthem in macaques infected with a Nef gene variant of SIVmac239. J Invest Dermatol. 1998 Jun; 110(6):894-901. PMID: 9620296.
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  147. Wykrzykowska JJ, Rosenzweig M, Veazey RS, Simon MA, Halvorsen K, Desrosiers RC, Johnson RP, Lackner AA. Early regeneration of thymic progenitors in rhesus macaques infected with simian immunodeficiency virus. J Exp Med. 1998 Jun 01; 187(11):1767-78. PMID: 9607918; PMCID: PMC2212305.
  148. Agosto M, Allan J, Benson C, Berger EA, Blumenthal R, Burton D, Clements J, Coffin J, Connor R, Cullen B, Desrosiers R, Dimitrov D, Doms R, Emerman M, Feinberg M, Fultz P, Gerard C, Gonsalves G, Haase A, Haigwood N, Hirsch V, Ho D, Hoxie JA, Hu SL, Zingale D, et al. AIDS vaccine development. Science. 1998 May 08; 280(5365):803, 804-5. PMID: 9599148.
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  149. Veazey RS, DeMaria M, Chalifoux LV, Shvetz DE, Pauley DR, Knight HL, Rosenzweig M, Johnson RP, Desrosiers RC, Lackner AA. Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science. 1998 Apr 17; 280(5362):427-31. PMID: 9545219.
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  150. Lee H, Veazey R, Williams K, Li M, Guo J, Neipel F, Fleckenstein B, Lackner A, Desrosiers RC, Jung JU. Deregulation of cell growth by the K1 gene of Kaposi's sarcoma-associated herpesvirus. Nat Med. 1998 Apr; 4(4):435-40. PMID: 9546789.
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  151. Duboise SM, Lee H, Guo J, Choi JK, Czajak S, Simon M, Desrosiers RC, Jung JU. Mutation of the Lck-binding motif of Tip enhances lymphoid cell activation by herpesvirus saimiri. J Virol. 1998 Apr; 72(4):2607-14. PMID: 9525577; PMCID: PMC109695.
  152. Desrosiers R. Does the HIV-1deltakURNe vaccine strain hold the key to curbing HIV infection? An interview with Ronald Desrosiers, PhD. J Int Assoc Physicians AIDS Care. 1998 Mar; 4(3):45-6. PMID: 11365180.
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  153. Desrosiers RC, Lifson JD, Gibbs JS, Czajak SC, Howe AY, Arthur LO, Johnson RP. Identification of highly attenuated mutants of simian immunodeficiency virus. J Virol. 1998 Feb; 72(2):1431-7. PMID: 9445045; PMCID: PMC124623.
  154. Duboise SM, Guo J, Czajak S, Desrosiers RC, Jung JU. STP and Tip are essential for herpesvirus saimiri oncogenicity. J Virol. 1998 Feb; 72(2):1308-13. PMID: 9445031; PMCID: PMC124609.
  155. Wooley DP, Smith RA, Czajak S, Desrosiers RC. Direct demonstration of retroviral recombination in a rhesus monkey. J Virol. 1997 Dec; 71(12):9650-3. PMID: 9371629; PMCID: PMC230273.
  156. Desrosiers RC, Sasseville VG, Czajak SC, Zhang X, Mansfield KG, Kaur A, Johnson RP, Lackner AA, Jung JU. A herpesvirus of rhesus monkeys related to the human Kaposi's sarcoma-associated herpesvirus. J Virol. 1997 Dec; 71(12):9764-9. PMID: 9371642; PMCID: PMC230286.
  157. Shibata R, Siemon C, Czajak SC, Desrosiers RC, Martin MA. Live, attenuated simian immunodeficiency virus vaccines elicit potent resistance against a challenge with a human immunodeficiency virus type 1 chimeric virus. J Virol. 1997 Nov; 71(11):8141-8. PMID: 9343164; PMCID: PMC192270.
  158. Du Z, Ilyinskii PO, Lally K, Desrosiers RC, Engelman A. A mutation in integrase can compensate for mutations in the simian immunodeficiency virus att site. J Virol. 1997 Nov; 71(11):8124-32. PMID: 9343162; PMCID: PMC192268.
  159. Johnson RP, Glickman RL, Yang JQ, Kaur A, Dion JT, Mulligan MJ, Desrosiers RC. Induction of vigorous cytotoxic T-lymphocyte responses by live attenuated simian immunodeficiency virus. J Virol. 1997 Oct; 71(10):7711-8. PMID: 9311855; PMCID: PMC192122.
  160. Means RE, Greenough T, Desrosiers RC. Neutralization sensitivity of cell culture-passaged simian immunodeficiency virus. J Virol. 1997 Oct; 71(10):7895-902. PMID: 9311879; PMCID: PMC192146.
  161. Alexander L, Du Z, Rosenzweig M, Jung JU, Desrosiers RC. A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 nef alleles in lymphocyte activation. J Virol. 1997 Aug; 71(8):6094-9. PMID: 9223503; PMCID: PMC191869.
  162. Cole KS, Rowles JL, Jagerski BA, Murphey-Corb M, Unangst T, Clements JE, Robinson J, Wyand MS, Desrosiers RC, Montelaro RC. Evolution of envelope-specific antibody responses in monkeys experimentally infected or immunized with simian immunodeficiency virus and its association with the development of protective immunity. J Virol. 1997 Jul; 71(7):5069-79. PMID: 9188572; PMCID: PMC191740.
  163. Alexander L, Lee H, Rosenzweig M, Jung JU, Desrosiers RC. EGFP-containing vector system that facilitates stable and transient expression assays. Biotechniques. 1997 Jul; 23(1):64-6. PMID: 9232229.
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  164. Kirchhoff F, Greenough TC, Hamacher M, Sullivan JL, Desrosiers RC. Activity of human immunodeficiency virus type 1 promoter/TAR regions and tat1 genes derived from individuals with different rates of disease progression. Virology. 1997 Jun 09; 232(2):319-31. PMID: 9191845.
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  165. Lee H, Trimble JJ, Yoon DW, Regier D, Desrosiers RC, Jung JU. Genetic variation of herpesvirus saimiri subgroup A transforming protein and its association with cellular src. J Virol. 1997 May; 71(5):3817-25. PMID: 9094657; PMCID: PMC191532.
  166. Giri A, Slattery JP, Heneine W, Gessain A, Rivadeneira E, Desrosiers RC, Rosen L, Anthony R, Pamungkas J, Iskandriati D, Richards AL, Herve V, McClure H, O'Brien SJ, Franchini G. The tax gene sequences form two divergent monophyletic lineages corresponding to types I and II of simian and human T-cell leukemia/lymphotropic viruses. Virology. 1997 Apr 28; 231(1):96-104. PMID: 9143307.
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  167. Ilyinskii PO, Simon MA, Czajak SC, Lackner AA, Desrosiers RC. Induction of AIDS by simian immunodeficiency virus lacking NF-kappaB and SP1 binding elements. J Virol. 1997 Mar; 71(3):1880-7. PMID: 9032318; PMCID: PMC191258.
  168. Zou W, Lackner AA, Simon M, Durand-Gasselin I, Galanaud P, Desrosiers RC, Emilie D. Early cytokine and chemokine gene expression in lymph nodes of macaques infected with simian immunodeficiency virus is predictive of disease outcome and vaccine efficacy. J Virol. 1997 Feb; 71(2):1227-36. PMID: 8995646; PMCID: PMC191177.
  169. Desrosiers RC. Approaches to AIDS research. Science. 1997 Jan 03; 275(5296):13. PMID: 8999523.
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  170. Wyand MS, Manson KH, Lackner AA, Desrosiers RC. Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus. Nat Med. 1997 Jan; 3(1):32-6. PMID: 8986737.
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  171. Desrosiers RC. The value of specific pathogen-free rhesus monkey breeding colonies for AIDS research. AIDS Res Hum Retroviruses. 1997 Jan 01; 13(1):5-6. PMID: 8989421.
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  173. Fauci AS and Desrosiers. pathogenesis of HIV and SIV. Retroviruses. Coffin JM, Hughes SH and Varmus HE (eds.). 1997; 587-635.
  174. Mariani R, Kirchhoff F, Greenough TC, Sullivan JL, Desrosiers RC, Skowronski J. High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J Virol. 1996 Nov; 70(11):7752-64. PMID: 8892896; PMCID: PMC190845.
  175. Duboise SM, Guo J, Desrosiers RC, Jung JU. Use of virion DNA as a cloning vector for the construction of mutant and recombinant herpesviruses. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11389-94. PMID: 8876145; PMCID: PMC38067.
  176. Sasseville VG, Pauley DR, Young HL, MacKey JJ, Simon MA, Desrosiers RC, Lackner AA. A case of pulmonary cestodiasis in a simian immunodeficiency virus-infected pigtailed macaque (Macaca nemestrina) in which virus-infected leukocytes are present within the lesion. J Med Primatol. 1996 Aug; 25(4):251-6. PMID: 8906603.
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  177. Sasseville VG, Du Z, Chalifoux LV, Pauley DR, Young HL, Sehgal PK, Desrosiers RC, Lackner AA. Induction of lymphocyte proliferation and severe gastrointestinal disease in macaques by a nef gene variant SIVmac239. Am J Pathol. 1996 Jul; 149(1):163-76. PMID: 8686740; PMCID: PMC1865222.
  178. Du Z, Ilyinskii PO, Sasseville VG, Newstein M, Lackner AA, Desrosiers RC. Requirements for lymphocyte activation by unusual strains of simian immunodeficiency virus. J Virol. 1996 Jun; 70(6):4157-61. PMID: 8648760; PMCID: PMC190308.
  179. Wyand MS, Manson KH, Garcia-Moll M, Montefiori D, Desrosiers RC. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J Virol. 1996 Jun; 70(6):3724-33. PMID: 8648707; PMCID: PMC190248.
  180. Giorgi JV, Hultin LE, Desrosiers RC. The immunopathogenesis of retroviral diseases: no immunophenotypic alterations in T, B, and NK cell subsets in SIVmac239-challenged rhesus macaques protected by SIV delta nef vaccination. J Med Primatol. 1996 Jun; 25(3):186-91. PMID: 8892039.
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  181. Ilyinskii PO, Desrosiers RC. Efficient transcription and replication of simian immunodeficiency virus in the absence of NF-kappaB and Sp1 binding elements. J Virol. 1996 May; 70(5):3118-26. PMID: 8627791; PMCID: PMC190174.
  182. Kirchhoff F, Desrosiers RC. Random mutagenesis of short target DNA sequences via PCR with degenerate oligonucleotides. Methods Mol Biol. 1996; 57:323-33. PMID: 8850018.
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  183. Lang SM, Desrosiers RC. Relative importance and functional role of genetic elements targeted for a live attenuated AIDS vaccine. Antibiot Chemother (1971). 1996; 48:92-9. PMID: 8726510.
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  184. Jung JU, Desrosiers RC. Association of the viral oncoprotein STP-C488 with cellular ras. Mol Cell Biol. 1995 Dec; 15(12):6506-12. PMID: 8524215; PMCID: PMC230903.
  185. Jung JU, Lang SM, Jun T, Roberts TM, Veillette A, Desrosiers RC. Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri. J Virol. 1995 Dec; 69(12):7814-22. PMID: 7494293; PMCID: PMC189725.
  186. Kirchhoff F, Morrison HG, Desrosiers RC. Identification of V3 mutations that can compensate for inactivating mutations in C4 of simian immunodeficiency virus. Virology. 1995 Oct 20; 213(1):179-89. PMID: 7483261.
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  187. Jung JU, Lang SM, Friedrich U, Jun T, Roberts TM, Desrosiers RC, Biesinger B. Identification of Lck-binding elements in tip of herpesvirus saimiri. J Biol Chem. 1995 Sep 01; 270(35):20660-7. PMID: 7544793.
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  188. Du Z, Lang SM, Sasseville VG, Lackner AA, Ilyinskii PO, Daniel MD, Jung JU, Desrosiers RC. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell. 1995 Aug 25; 82(4):665-74. PMID: 7664345.
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  189. Morrison HG, Kirchhoff F, Desrosiers RC. Effects of mutations in constant regions 3 and 4 of envelope of simian immunodeficiency virus. Virology. 1995 Jul 10; 210(2):448-55. PMID: 7618279.
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  190. Gibbs JS, Lackner AA, Lang SM, Simon MA, Sehgal PK, Daniel MD, Desrosiers RC. Progression to AIDS in the absence of a gene for vpr or vpx. J Virol. 1995 Apr; 69(4):2378-83. PMID: 7884883; PMCID: PMC188910.
  191. Du Z, Regier DA, Desrosiers RC. Improved recombinant PCR mutagenesis procedure that uses alkaline-denatured plasmid template. Biotechniques. 1995 Mar; 18(3):376-8. PMID: 7779381.
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  192. Kirchhoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med. 1995 Jan 26; 332(4):228-32. PMID: 7808489.
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  193. Du Z, Lang SM, Sasseville VG, Lackner AA, Ilyinskii PO, Daniel MD, Jung JU, Desrosiers RC. A role for nef in signal transduction and lymphocyte activation. Dixieme Colloque Des Cent Gardes. 1995; 45-47.
  194. Desrosiers RC. Non-human primate models for AIDS vaccines. AIDS. 1995; 9 Suppl A:S137-41. PMID: 8819580.
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  197. Lang SM and Desrosiers RC. Relative importance and functional role of genetic elements targeted for a live attenuated AIDS vaccine. Development and Applications of Vaccines and Gene Therapy in AIDS. Antibiot Chemother. Giraldo G, Bolognesi DP, Salvatore M, Beth-Giraldo E, Schonfeld H. 1995; 48:92-99.
  198. Desrosiers RC, Daniel MD, Lifson J, Arthur LO. Infection of chimpanzees with attenuated HIV-1 deletion mutants. Dixieme Colloque Des Gardes. 1995; 197-200.
  199. Jin MJ, Rogers J, Phillips-Conroy JE, Allan JS, Desrosiers RC, Shaw GM, Sharp PM, Hahn BH. Infection of a yellow baboon with simian immunodeficiency virus from African green monkeys: evidence for cross-species transmission in the wild. J Virol. 1994 Dec; 68(12):8454-60. PMID: 7966642; PMCID: PMC237322.
  200. Jung JU, Desrosiers RC. Distinct functional domains of STP-C488 of herpesvirus saimiri. Virology. 1994 Nov 01; 204(2):751-8. PMID: 7941343.
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  201. Jung JU, Stäger M, Desrosiers RC. Virus-encoded cyclin. Mol Cell Biol. 1994 Nov; 14(11):7235-44. PMID: 7935438; PMCID: PMC359258.
  202. Ilyinskii PO, Daniel MD, Simon MA, Lackner AA, Desrosiers RC. The role of upstream U3 sequences in the pathogenesis of simian immunodeficiency virus-induced AIDS in rhesus monkeys. J Virol. 1994 Sep; 68(9):5933-44. PMID: 7914551; PMCID: PMC236999.
  203. Choi WS, Collignon C, Thiriart C, Burns DP, Stott EJ, Kent KA, Desrosiers RC. Effects of natural sequence variation on recognition by monoclonal antibodies neutralize simian immunodeficiency virus infectivity. J Virol. 1994 Sep; 68(9):5395-402. PMID: 7520089; PMCID: PMC236939.
  204. Daniel MD, Mazzara GP, Simon MA, Sehgal PK, Kodama T, Panicali DL, Desrosiers RC. High-titer immune responses elicited by recombinant vaccinia virus priming and particle boosting are ineffective in preventing virulent SIV infection. AIDS Res Hum Retroviruses. 1994 Jul; 10(7):839-51. PMID: 7986589.
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  206. Simon MA, Brodie SJ, Sasseville VG, Chalifoux LV, Desrosiers RC, Ringler DJ. Immunopathogenesis of SIVmac. Virus Res. 1994 May; 32(2):227-51. PMID: 8067055.
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  207. Gibbs JS, Regier DA, Desrosiers RC. Construction and in vitro properties of SIVmac mutants with deletions in "nonessential" genes. AIDS Res Hum Retroviruses. 1994 May; 10(5):607-16. PMID: 7917522.
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  208. Gibbs JS, Regier DA, Desrosiers RC. Construction and in vitro properties of HIV-1 mutants with deletions in "nonessential" genes. AIDS Res Hum Retroviruses. 1994 Apr; 10(4):343-50. PMID: 8068414.
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  210. Desrosiers RC. Safety issues facing development of a live-attenuated, multiply deleted HIV-1 vaccine. AIDS Res Hum Retroviruses. 1994 Apr; 10(4):331-2. PMID: 8068412.
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  211. Kirchhoff F, Kestler HW, Desrosiers RC. Upstream U3 sequences in simian immunodeficiency virus are selectively deleted in vivo in the absence of an intact nef gene. J Virol. 1994 Mar; 68(3):2031-7. PMID: 8107267; PMCID: PMC236672.
  212. Kirchhoff F, Morrison HG, Murray MG, Rennert P, Desrosiers RC. SIVmac expressing hybrid envelope proteins containing HIV-1 V3 and/or C4 sequences is not competent for replication. AIDS Res Hum Retroviruses. 1994 Mar; 10(3):309-13. PMID: 8018392.
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  213. Lewis MG, Bellah S, McKinnon K, Yalley-Ogunro J, Zack PM, Elkins WR, Desrosiers RC, Eddy GA. Titration and characterization of two rhesus-derived SIVmac challenge stocks. AIDS Res Hum Retroviruses. 1994 Feb; 10(2):213-20. PMID: 8198874.
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  214. Hunt RD, Desrosiers RC. Study of spontaneous infectious diseases of primates: Contribution of the Regional Primate Research Centers programs to conservation and new scientific opportunities. Am J Primatol. 1994; (34):3-10.
  215. Jung JU and Desrosiers RC. Herpesviruses saimiri and ateles. Encyclopedia of Virology. Webster R and Granoff A (eds.). 1994; 614-22.
  216. Balayan M et al (World Health Organization Working Group). Feasibility of developing live attenuated HIV vaccines: conclusions and recommendations. AIDS res Hum Retroviruses. 1994; (10):221-22.
  217. Murphy C, Kretschmer C, Biesinger B, Beckers J, Jung J, Desrosiers RC, Müller-Hermelink HK, Fleckenstein BW, Rüther U. Epithelial tumours induced by a herpesvirus oncogene in transgenic mice. Oncogene. 1994 Jan; 9(1):221-6. PMID: 8302583.
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  218. Burns DP, Desrosiers RC. Envelope sequence variation, neutralizing antibodies, and primate lentivirus persistence. Curr Top Microbiol Immunol. 1994; 188:185-219. PMID: 7523031.
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  222. Phillips-Conroy JE, Jolly CJ, Petros B, Allan JS, Desrosiers RC. Sexual transmission of SIVagm in wild grivet monkeys. J Med Primatol. 1994 Jan; 23(1):1-7. PMID: 7932633.
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  223. Kodama T, Mori K, Kawahara T, Ringler DJ, Desrosiers RC. Analysis of simian immunodeficiency virus sequence variation in tissues of rhesus macaques with simian AIDS. J Virol. 1993 Nov; 67(11):6522-34. PMID: 8411355; PMCID: PMC238089.
  224. Berend KR, Jung JU, Boyle TJ, DiMaio JM, Mungal SA, Desrosiers RC, Lyerly HK. Phenotypic and functional consequences of herpesvirus saimiri infection of human CD8+ cytotoxic T lymphocytes. J Virol. 1993 Oct; 67(10):6317-21. PMID: 8396687; PMCID: PMC238060.
  225. Burns DP, Collignon C, Desrosiers RC. Simian immunodeficiency virus mutants resistant to serum neutralization arise during persistent infection of rhesus monkeys. J Virol. 1993 Jul; 67(7):4104-13. PMID: 8510218; PMCID: PMC237779.
  226. Morrison HG, Kirchhoff F, Desrosiers RC. Evidence for the cooperation of gp120 amino acids 322 and 448 in SIVmac entry. Virology. 1993 Jul; 195(1):167-74. PMID: 8317093.
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  227. Nathanson N, McGann KA, Wilesmith J, Desrosiers RC, Brookmeyer R. The evolution of virus diseases: their emergence, epidemicity, and control. Virus Res. 1993 Jul; 29(1):3-20. PMID: 8212850.
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  228. Mori K, Ringler DJ, Desrosiers RC. Restricted replication of simian immunodeficiency virus strain 239 in macrophages is determined by env but is not due to restricted entry. J Virol. 1993 May; 67(5):2807-14. PMID: 7682627; PMCID: PMC237605.
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  230. Morrison HG, Desrosiers RC. A PCR-based strategy for extensive mutagenesis of a target DNA sequence. Biotechniques. 1993 Mar; 14(3):454-7. PMID: 8457353.
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  231. Fickenscher H, Grassman R, Biesinger B, Ramstedt U, Haseltine WA, Desrosiers RC, Fleckenstein B. Viral genes involved in stable growth transformation of human T-lymphocytes. Virus Strategies Molecular Biology and Pathogenesis. Doerfler W and Bohm P (eds.). 1993; 401-06.
  232. Desrosiers RC and Ringler DJ. Viral determinants of neurological disease in AIDS. Discussions in Neuroscience: Molecular and Cellular Mechanisms of Neural-Immune Interactions. Wiesel T, Anderson D and Katz L (eds.). 1993; IX(3+4):52-55.
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  236. Cranage MP, Polyanskaya N, McBride B, Cook N, Ashworth LAE, Dennis M, Baskerville A, Greenaway PJ, Corcoran T, Kitchin P, Rose J, Murphey-Corb M, Desrosiers RC, Stott EJ, Farrar GH. Studies on the specificity of the vaccine effect elicited by inactivated simian immunodeficiency virus. AIDS Res Hum Retroviruses. 1993; (9):13-22.
  237. Gibbs JS and Desrosiers RC. Auxiliary proteins of primate immunodeficiency viruses. Human Retroviruses: Frontiers in Moleuclar Biology. Cullen, BR (ed.). 1993; Chapter 6:137-58.
  238. Daniel MD, Kirchhoff F, Czajak SC, Sehgal PK, Desrosiers RC. Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science. 1992 Dec 18; 258(5090):1938-41. PMID: 1470917.
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  360. Falk L, Desrosiers RC, Hunt RD. Herpesvirus saimiri infection in squirrel and marmoset monkeys. Viruses in Naturally Occurring Cancers. Essex M, zur Hausen H, Todaro G, eds. 1980; (7):137-143.
  361. Lengyel P, Desrosiers RC, Broeze R, Slattery E, Taira H, Dougherty J, Samanta H, Pichon J, Farrell P, Ratner L, Sen G. Biochemistry of the Interferon System. Microbiology. David Schlessinger. 1980; (49):219-226.
  362. Desrosiers RC, Mulder C, Fleckenstein B. Methylation of Herpesvirus saimiri DNA in lymphoid tumor cell lines. Proc Natl Acad Sci U S A. 1979 Aug; 76(8):3839-43. PMID: 226983; PMCID: PMC383930.
  363. Desrosiers RC, Lengyel P. Impairment of reovirus mRNA 'cap' methylation in interferon-treated mouse L929 cells. Biochim Biophys Acta. 1979 May 24; 562(3):471-80. PMID: 454611.
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  364. Werner FJ, Desrosiers RC, Mulder C, Bornkamm GW, Fleckenstein B. Physical mapping of viral episomes in Herpesvirus saimiri transformed lymphoid cells. Persistent Viruses: ICN-UCLA Symposia in Molecular and Cellular Biology. Stevens JG, Todaro GJ, Fox CF (eds.). 1978; XI:189-200.
  365. Sen GC, Shaila S, Lebleu B, Brown GE, Desrosiers RC, Lengyel P. Impairment of reovirus mRNA methylation in extracts of interferon-treated Ehrilich ascites tumor cells: further characteristics of the phenomenon. J Virol. 1977 Jan; 21(1):69-83. PMID: 556782; PMCID: PMC353792.
  366. Sen GC, Desrosiers R, Ratner L, Shaila S, Brown GE, Lebleu B, Slattery E, Kawakita M, Cabrer B, Taira H, Lengyel P. Messenger RNA methylation, translation and degradation in extracts of interferon-treated cells. Tex Rep Biol Med. 1977; 35:221-9. PMID: 358450.
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  367. Desrosiers RC, Sen GC, Lengyel P. Difference in 5' terminal structure between the mRNA and the double-stranded virion RNA of reovirus. Biochem Biophys Res Commun. 1976 Nov 08; 73(1):32-9. PMID: 999700.
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  368. Desrosiers RC, Rottman FM, Boezi JA, Towle HC. The sensitivity of RNA polymerases I and II from Novikoff hepatoma (N1S1) cells to 3'-deoxyadenosine 5'-triphosphate. Nucleic Acids Res. 1976 Feb; 3(2):325-41. PMID: 176630; PMCID: PMC342904.
  369. Rottman FM, Desrosiers RC, Friderici K. Nucleotide methylation patterns in eukaryotic mRNA. Prog Nucleic Acid Res Mol Biol. 1976; 19:21-38. PMID: 190642.
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  370. Desrosiers RC, Friderici KH, Rottman FM. Characterization of Novikoff hepatoma mRNA methylation and heterogeneity in the methylated 5' terminus. Biochemistry. 1975 Oct 07; 14(20):4367-74. PMID: 169893.
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  371. Desrosiers R, Friderici K, Rottman F. Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci U S A. 1974 Oct; 71(10):3971-5. PMID: 4372599; PMCID: PMC434308.
  372. Desrosiers RC, Friderici KH, Rottman FM. Identification methylated nucleosides in messenger RNA from Novikoff hepatoma cells. Proc Natl Acad Sci USA. 1974; (1971):3971-75.
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