Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Dai Fukumura, Ph.D., M.D.

Title
Institution
Department
Address
Phone
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Mentoring
completed student projects
Anti-angiogenic agents may enhance the effectiveness of breast cancer immune therapies
Full Time, 05/31/12 - 05/31/14

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01CA208205 (FUKUMURA, DAI) Jun 15, 2017 - May 31, 2022
    NIH/NCI
    Reengineering obesity-induced abnormal microenvironment to improve PDAC treatment
    Role: Principal Investigator
  2. S10RR027070 (FUKUMURA, DAI) Aug 1, 2010 - Jul 31, 2013
    NIH/NCRR
    Doppler Optical Frequency Domain Imaging Instrument
    Role: Principal Investigator
  3. R01CA096915 (FUKUMURA, DAI) Jul 1, 2002 - Jun 30, 2007
    NIH/NCI
    Nitric Oxide in Tumor Angiogenesis, Microcirculation and Radiation Therapy
    Role: Principal Investigator
  4. P01CA080124 (JAIN, RAKESH K.) Aug 1, 2001 - Nov 30, 2005
    NIH/NCI
    Integrative Pathophysiology of Solid Tumors
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Valiente M, Van Swearingen AED, Anders CK, Bairoch A, Boire A, Bos PD, Cittelly DM, Erez N, Ferraro GB, Fukumura D, Gril B, Herlyn M, Holmen SL, Jain RK, Joyce JA, Lorger M, Massague J, Neman J, Sibson NR, Steeg PS, Thorsen F, Young LS, Varešlija D, Vultur A, Weis-Garcia F, Winkler F. Brain Metastasis Cell Lines Panel: a public resource of organotropic cell lines. Cancer Res. 2020 Jul 08. PMID: 32641416.
    Citations:    
  2. Millar DG, Ramjiawan RR, Kawaguchi K, Gupta N, Chen J, Zhang S, Nojiri T, Ho WW, Aoki S, Jung K, Chen I, Shi F, Heather JM, Shigeta K, Morton LT, Sepulveda S, Wan L, Joseph R, Minogue E, Khatri A, Bardia A, Ellisen LW, Corcoran RB, Hata AN, Pai SI, Jain RK, Fukumura D, Duda DG, Cobbold M. Antibody-mediated delivery of viral epitopes to tumors harnesses CMV-specific T cells for cancer therapy. Nat Biotechnol. 2020 04; 38(4):420-425. PMID: 32042168.
    Citations:    
  3. Shvedova M, Litvak MM, Roberts JD, Fukumura D, Suzuki T, Sencan I, Li G, Reventun P, Buys ES, Kim HH, Sakadžic S, Ayata C, Huang PL, Feil R, Atochin DN. cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice. J Cereb Blood Flow Metab. 2019 12; 39(12):2379-2391. PMID: 31423931.
    Citations:    
  4. Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N. Retraction Note: A homing system targets therapeutic T cells to brain cancer. Nature. 2019 03; 567(7746):132. PMID: 30787441.
    Citations:    
  5. Voutouri C, Kirkpatrick ND, Chung E, Mpekris F, Baish JW, Munn LL, Fukumura D, Stylianopoulos T, Jain RK. Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies. Proc Natl Acad Sci U S A. 2019 02 12; 116(7):2662-2671. PMID: 30700544.
    Citations:    Fields:    
  6. Askoxylakis V, Ferraro GB, Badeaux M, Kodack DP, Kirst I, Shankaraiah RC, Wong CSF, Duda DG, Fukumura D, Jain RK. Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer. NPJ Breast Cancer. 2019; 5:4. PMID: 30675514.
    Citations:    
  7. Seano G, Nia HT, Emblem KE, Datta M, Ren J, Krishnan S, Kloepper J, Pinho MC, Ho WW, Ghosh M, Askoxylakis V, Ferraro GB, Riedemann L, Gerstner ER, Batchelor TT, Wen PY, Lin NU, Grodzinsky AJ, Fukumura D, Huang P, Baish JW, Padera TP, Munn LL, Jain RK. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nat Biomed Eng. 2019 03; 3(3):230-245. PMID: 30948807.
    Citations:    
  8. Samaha H, Pignata A, Fousek K, Ren J, Lam FW, Stossi F, Dubrulle J, Salsman VS, Krishnan S, Hong SH, Baker ML, Shree A, Gad AZ, Shum T, Fukumura D, Byrd TT, Mukherjee M, Marrelli SP, Orange JS, Joseph SK, Sorensen PH, Taylor MD, Hegde M, Mamonkin M, Jain RK, El-Naggar S, Ahmed N. A homing system targets therapeutic T cells to brain cancer. Nature. 2018 09; 561(7723):331-337. PMID: 30185905.
    Citations:    Fields:    
  9. Arvanitis CD, Askoxylakis V, Guo Y, Datta M, Kloepper J, Ferraro GB, Bernabeu MO, Fukumura D, McDannold N, Jain RK. Mechanisms of enhanced drug delivery in brain metastases with focused ultrasound-induced blood-tumor barrier disruption. Proc Natl Acad Sci U S A. 2018 09 11; 115(37):E8717-E8726. PMID: 30150398.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532. PMID: 29766399.
    Citations: 3     Fields:    
  11. Carr JA, Franke D, Caram JR, Perkinson CF, Saif M, Askoxylakis V, Datta M, Fukumura D, Jain RK, Bawendi MG, Bruns OT. Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green. Proc Natl Acad Sci U S A. 2018 04 24; 115(17):4465-4470. PMID: 29626132.
    Citations: 4     Fields:    Translation:Animals
  12. Incio J, Ligibel JA, McManus DT, Suboj P, Jung K, Kawaguchi K, Pinter M, Babykutty S, Chin SM, Vardam TD, Huang Y, Rahbari NN, Roberge S, Wang D, Gomes-Santos IL, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Tolaney SM, Krop IE, Duda DG, Boucher Y, Fukumura D, Jain RK. Obesity promotes resistance to anti-VEGF therapy in breast cancer by up-regulating IL-6 and potentially FGF-2. Sci Transl Med. 2018 03 14; 10(432). PMID: 29540614.
    Citations: 1     Fields:    
  13. Fukumura D, Kloepper J, Amoozgar Z, Duda DG, Jain RK. Enhancing cancer immunotherapy using antiangiogenics: opportunities and challenges. Nat Rev Clin Oncol. 2018 05; 15(5):325-340. PMID: 29508855.
    Citations: 3     Fields:    
  14. Dixon KO, Schorer M, Nevin J, Etminan Y, Amoozgar Z, Kondo T, Kurtulus S, Kassam N, Sobel RA, Fukumura D, Jain RK, Anderson AC, Kuchroo VK, Joller N. Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity. J Immunol. 2018 04 15; 200(8):3000-3007. PMID: 29500245.
    Citations: 2     Fields:    
  15. Li W, Liu Y, Yang W, Han X, Li S, Liu H, Gerweck LE, Fukumura D, Loeffler JS, Yang BB, Jain RK, Huang P. MicroRNA-378 enhances radiation response in ectopic and orthotopic implantation models of glioblastoma. J Neurooncol. 2018 Jan; 136(1):63-71. PMID: 29081036.
    Citations:    Fields:    Translation:HumansAnimalsCells
  16. Askoxylakis V, Badeaux M, Roberge S, Batista A, Kirkpatrick N, Snuderl M, Amoozgar Z, Seano G, Ferraro GB, Chatterjee S, Xu L, Fukumura D, Duda DG, Jain RK. A cerebellar window for intravital imaging of normal and disease states in mice. Nat Protoc. 2017 Nov; 12(11):2251-2262. PMID: 28981123.
    Citations:    Fields:    Translation:Animals
  17. Jung K, Heishi T, Incio J, Huang Y, Beech EY, Pinter M, Ho WW, Kawaguchi K, Rahbari NN, Chung E, Kim JK, Clark JW, Willett CG, Yun SH, Luster AD, Padera TP, Jain RK, Fukumura D. Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10455-10460. PMID: 28900008.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D. Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. J Clin Invest. 2017 Aug 01; 127(8):3039-3051. PMID: 28691930.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  19. Kodack DP, Askoxylakis V, Ferraro GB, Sheng Q, Badeaux M, Goel S, Qi X, Shankaraiah R, Cao ZA, Ramjiawan RR, Bezwada D, Patel B, Song Y, Costa C, Naxerova K, Wong CSF, Kloepper J, Das R, Tam A, Tanboon J, Duda DG, Miller CR, Siegel MB, Anders CK, Sanders M, Estrada MV, Schlegel R, Arteaga CL, Brachtel E, Huang A, Fukumura D, Engelman JA, Jain RK. The brain microenvironment mediates resistance in luminal breast cancer to PI3K inhibition through HER3 activation. Sci Transl Med. 2017 05 24; 9(391). PMID: 28539475.
    Citations: 8     Fields:    Translation:Animals
  20. Rowlands CJ, Park D, Bruns OT, Piatkevich KD, Fukumura D, Jain RK, Bawendi MG, Boyden ES, So PT. Wide-field three-photon excitation in biological samples. Light Sci Appl. 2017 May 05; 6:e16255. PMID: 29152380.
    Citations: 1     
  21. Bruns OT, Bischof TS, Harris DK, Franke D, Shi Y, Riedemann L, Bartelt A, Jaworski FB, Carr JA, Rowlands CJ, Wilson MWB, Chen O, Wei H, Hwang GW, Montana DM, Coropceanu I, Achorn OB, Kloepper J, Heeren J, So PTC, Fukumura D, Jensen KF, Jain RK, Bawendi MG. Next-generation in vivo optical imaging with short-wave infrared quantum dots. Nat Biomed Eng. 2017; 1. PMID: 29119058.
    Citations: 9     
  22. Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Corrigendum: Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harb Perspect Med. 2016 12 01; 6(12). PMID: 27908927.
    Citations:    Fields:    
  23. Martin JD, Fukumura D, Duda DG, Boucher Y, Jain RK. Reengineering the Tumor Microenvironment to Alleviate Hypoxia and Overcome Cancer Heterogeneity. Cold Spring Harb Perspect Med. 2016 Dec 01; 6(12). PMID: 27663981.
    Citations: 9     Fields:    Translation:Humans
  24. Nia HT, Liu H, Seano G, Datta M, Jones D, Rahbari N, Incio J, Chauhan VP, Jung K, Martin JD, Askoxylakis V, Padera TP, Fukumura D, Boucher Y, Hornicek FJ, Grodzinsky AJ, Baish JW, Munn LL, Jain RK. Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016; 1. PMID: 28966873.
    Citations: 15     
  25. Rahbari NN, Kedrin D, Incio J, Liu H, Ho WW, Nia HT, Edrich CM, Jung K, Daubriac J, Chen I, Heishi T, Martin JD, Huang Y, Maimon N, Reissfelder C, Weitz J, Boucher Y, Clark JW, Grodzinsky AJ, Duda DG, Jain RK, Fukumura D. Anti-VEGF therapy induces ECM remodeling and mechanical barriers to therapy in colorectal cancer liver metastases. Sci Transl Med. 2016 10 12; 8(360):360ra135. PMID: 27733559.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  26. Incio J, Liu H, Suboj P, Chin SM, Chen IX, Pinter M, Ng MR, Nia HT, Grahovac J, Kao S, Babykutty S, Huang Y, Jung K, Rahbari NN, Han X, Chauhan VP, Martin JD, Kahn J, Huang P, Desphande V, Michaelson J, Michelakos TP, Ferrone CR, Soares R, Boucher Y, Fukumura D, Jain RK. Obesity-Induced Inflammation and Desmoplasia Promote Pancreatic Cancer Progression and Resistance to Chemotherapy. Cancer Discov. 2016 08; 6(8):852-69. PMID: 27246539.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  27. Patil MD, Bhaumik J, Babykutty S, Banerjee UC, Fukumura D. Arginine dependence of tumor cells: targeting a chink in cancer's armor. Oncogene. 2016 09 22; 35(38):4957-72. PMID: 27109103.
    Citations: 9     Fields:    Translation:HumansCells
  28. Peterson TE, Kirkpatrick ND, Huang Y, Farrar CT, Marijt KA, Kloepper J, Datta M, Amoozgar Z, Seano G, Jung K, Kamoun WS, Vardam T, Snuderl M, Goveia J, Chatterjee S, Batista A, Muzikansky A, Leow CC, Xu L, Batchelor TT, Duda DG, Fukumura D, Jain RK. Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4470-5. PMID: 27044097.
    Citations: 33     Fields:    Translation:AnimalsCells
  29. Kloepper J, Riedemann L, Amoozgar Z, Seano G, Susek K, Yu V, Dalvie N, Amelung RL, Datta M, Song JW, Askoxylakis V, Taylor JW, Lu-Emerson C, Batista A, Kirkpatrick ND, Jung K, Snuderl M, Muzikansky A, Stubenrauch KG, Krieter O, Wakimoto H, Xu L, Munn LL, Duda DG, Fukumura D, Batchelor TT, Jain RK. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4476-81. PMID: 27044098.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  30. Fukumura D, Incio J, Shankaraiah RC, Jain RK. Obesity and Cancer: An Angiogenic and Inflammatory Link. Microcirculation. 2016 Apr; 23(3):191-206. PMID: 26808917.
    Citations: 9     Fields:    Translation:HumansAnimals
  31. Incio J, Tam J, Rahbari NN, Suboj P, McManus DT, Chin SM, Vardam TD, Batista A, Babykutty S, Jung K, Khachatryan A, Hato T, Ligibel JA, Krop IE, Puchner SB, Schlett CL, Hoffmman U, Ancukiewicz M, Shibuya M, Carmeliet P, Soares R, Duda DG, Jain RK, Fukumura D. PlGF/VEGFR-1 Signaling Promotes Macrophage Polarization and Accelerated Tumor Progression in Obesity. Clin Cancer Res. 2016 06 15; 22(12):2993-3004. PMID: 26861455.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  32. Park KR, Monsky WL, Lee CG, Song CH, Kim DH, Jain RK, Fukumura D. Mast Cells Contribute to Radiation-Induced Vascular Hyperpermeability. Radiat Res. 2016 Feb; 185(2):182-9. PMID: 26771172.
    Citations: 7     Fields:    Translation:AnimalsCells
  33. Whitley MJ, Cardona DM, Lazarides AL, Spasojevic I, Ferrer JM, Cahill J, Lee CL, Snuderl M, Blazer DG, Hwang ES, Greenup RA, Mosca PJ, Mito JK, Cuneo KC, Larrier NA, O'Reilly EK, Riedel RF, Eward WC, Strasfeld DB, Fukumura D, Jain RK, Lee WD, Griffith LG, Bawendi MG, Kirsch DG, Brigman BE. A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. Sci Transl Med. 2016 Jan 06; 8(320):320ra4. PMID: 26738797.
    Citations: 29     Fields:    Translation:HumansAnimalsCTClinical Trials
  34. Meijer EF, Baish JW, Padera TP, Fukumura D. Measuring Vascular Permeability In Vivo. Methods Mol Biol. 2016; 1458:71-85. PMID: 27581015.
    Citations: 1     Fields:    Translation:HumansAnimals
  35. Singhal PK, Sassi S, Lan L, Au P, Halvorsen SC, Fukumura D, Jain RK, Seed B. Mouse embryonic fibroblasts exhibit extensive developmental and phenotypic diversity. Proc Natl Acad Sci U S A. 2016 Jan 05; 113(1):122-7. PMID: 26699463.
    Citations: 8     Fields:    Translation:AnimalsCells
  36. Incio J, Suboj P, Chin SM, Vardam-Kaur T, Liu H, Hato T, Babykutty S, Chen I, Deshpande V, Jain RK, Fukumura D. Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. PLoS One. 2015; 10(12):e0141392. PMID: 26641266.
    Citations: 23     Fields:    Translation:AnimalsCells
  37. Askoxylakis V, Ferraro GB, Kodack DP, Badeaux M, Shankaraiah RC, Seano G, Kloepper J, Vardam T, Martin JD, Naxerova K, Bezwada D, Qi X, Selig MK, Brachtel E, Duda DG, Huang P, Fukumura D, Engelman JA, Jain RK. Preclinical Efficacy of Ado-trastuzumab Emtansine in the Brain Microenvironment. J Natl Cancer Inst. 2016 Feb; 108(2). PMID: 26547932.
    Citations: 8     Fields:    Translation:Animals
  38. Samuel R, Duda DG, Fukumura D, Jain RK. Vascular diseases await translation of blood vessels engineered from stem cells. Sci Transl Med. 2015 Oct 14; 7(309):309rv6. PMID: 26468328.
    Citations: 4     Fields:    Translation:HumansCells
  39. Lemon CM, Karnas E, Han X, Bruns OT, Kempa TJ, Fukumura D, Bawendi MG, Jain RK, Duda DG, Nocera DG. Micelle-Encapsulated Quantum Dot-Porphyrin Assemblies as in Vivo Two-Photon Oxygen Sensors. J Am Chem Soc. 2015 Aug 12; 137(31):9832-42. PMID: 26149349.
    Citations: 8     Fields:    Translation:AnimalsCells
  40. Jain RK, Fukumura D, Duda DG. From the Guest Editors: Role of Tumor Microenvironment in Tumor Progression and Treatment Response: A 30 Years' Journey. Cancer J. 2015 Jul-Aug; 21(4):235-6. PMID: 26222072.
    Citations: 2     Fields:    Translation:Humans
  41. Jain RK, Fukumura D, Duda DG. Lessons From 30 Years of Teaching About the Microenvironment of Tumors. Cancer J. 2015 May-Jun; 21(3):137. PMID: 26049690.
    Citations:    Fields:    Translation:Humans
  42. Choi JW, Kim P, Kim JK, Kim YR, Fukumura D, Yun SH. Longitudinal Tracing of Spontaneous Regression and Anti-angiogenic Response of Individual Microadenomas during Colon Tumorigenesis. Theranostics. 2015; 5(7):724-32. PMID: 25897337.
    Citations: 1     Fields:    Translation:Animals
  43. Ager EI, Kozin SV, Kirkpatrick ND, Seano G, Kodack DP, Askoxylakis V, Huang Y, Goel S, Snuderl M, Muzikansky A, Finkelstein DM, Dransfield DT, Devy L, Boucher Y, Fukumura D, Jain RK. Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy. J Natl Cancer Inst. 2015 Apr; 107(4). PMID: 25710962.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  44. Stylianopoulos T, Economides EA, Baish JW, Fukumura D, Jain RK. Towards Optimal Design of Cancer Nanomedicines: Multi-stage Nanoparticles for the Treatment of Solid Tumors. Ann Biomed Eng. 2015 Sep; 43(9):2291-300. PMID: 25670323.
    Citations: 5     Fields:    Translation:Humans
  45. Kodack DP, Askoxylakis V, Ferraro GB, Fukumura D, Jain RK. Emerging strategies for treating brain metastases from breast cancer. Cancer Cell. 2015 Feb 09; 27(2):163-75. PMID: 25670078.
    Citations: 26     Fields:    Translation:Humans
  46. Han HS, Niemeyer E, Huang Y, Kamoun WS, Martin JD, Bhaumik J, Chen Y, Roberge S, Cui J, Martin MR, Fukumura D, Jain RK, Bawendi MG, Duda DG. Quantum dot/antibody conjugates for in vivo cytometric imaging in mice. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1350-5. PMID: 25605916.
    Citations: 13     Fields:    Translation:Animals
  47. Thunemann M, Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R. Correlative intravital imaging of cGMP signals and vasodilation in mice. Front Physiol. 2014; 5:394. PMID: 25352809.
    Citations: 8     
  48. Chen O, Riedemann L, Etoc F, Herrmann H, Coppey M, Barch M, Farrar CT, Zhao J, Bruns OT, Wei H, Guo P, Cui J, Jensen R, Chen Y, Harris DK, Cordero JM, Wang Z, Jasanoff A, Fukumura D, Reimer R, Dahan M, Jain RK, Bawendi MG. Magneto-fluorescent core-shell supernanoparticles. Nat Commun. 2014 Oct 09; 5:5093. PMID: 25298155.
    Citations: 9     Fields:    
  49. Huang Y, Stylianopoulos T, Duda DG, Fukumura D, Jain RK. Benefits of vascular normalization are dose and time dependent--letter. Cancer Res. 2013 Dec 01; 73(23):7144-6. PMID: 24265277.
    Citations: 19     Fields:    Translation:HumansAnimals
  50. Goel S, Gupta N, Walcott BP, Snuderl M, Kesler CT, Kirkpatrick ND, Heishi T, Huang Y, Martin JD, Ager E, Samuel R, Wang S, Yazbek J, Vakoc BJ, Peterson RT, Padera TP, Duda DG, Fukumura D, Jain RK. Effects of vascular-endothelial protein tyrosine phosphatase inhibition on breast cancer vasculature and metastatic progression. J Natl Cancer Inst. 2013 Aug 21; 105(16):1188-201. PMID: 23899555.
    Citations: 31     Fields:    Translation:AnimalsCells
  51. Samuel R, Daheron L, Liao S, Vardam T, Kamoun WS, Batista A, Buecker C, Schäfer R, Han X, Au P, Scadden DT, Duda DG, Fukumura D, Jain RK. Generation of functionally competent and durable engineered blood vessels from human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31):12774-9. PMID: 23861493.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  52. Jain RK, Munn LL, Fukumura D. Measuring interstitial diffusion, convection, and binding parameters in mouse tumors. Cold Spring Harb Protoc. 2013 Jul 01; 2013(7):678-80. PMID: 23818670.
    Citations: 1     Fields:    Translation:AnimalsCells
  53. Jain RK, Munn LL, Fukumura D. Measuring interstitial pH and pO2 in mouse tumors. Cold Spring Harb Protoc. 2013 Jul 01; 2013(7):675-7. PMID: 23818669.
    Citations:    Fields:    Translation:AnimalsCells
  54. Thunemann M, Wen L, Hillenbrand M, Vachaviolos A, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R. Transgenic mice for cGMP imaging. Circ Res. 2013 Aug 02; 113(4):365-71. PMID: 23801067.
    Citations: 20     Fields:    Translation:AnimalsCells
  55. Jain RK, Munn LL, Fukumura D. Measuring leukocyte-endothelial interactions in mice. Cold Spring Harb Protoc. 2013 Jun 01; 2013(6):561-3. PMID: 23734020.
    Citations: 1     Fields:    Translation:AnimalsCells
  56. Jain RK, Munn LL, Fukumura D. Measuring vascular permeability in mice. Cold Spring Harb Protoc. 2013 May 01; 2013(5):444-6. PMID: 23637370.
    Citations: 1     Fields:    Translation:Animals
  57. Jain RK, Munn LL, Fukumura D. Measuring angiogenesis and hemodynamics in mice. Cold Spring Harb Protoc. 2013 Apr 01; 2013(4):354-8. PMID: 23547161.
    Citations: 3     Fields:    Translation:Animals
  58. Snuderl M, Batista A, Kirkpatrick ND, Ruiz de Almodovar C, Riedemann L, Walsh EC, Anolik R, Huang Y, Martin JD, Kamoun W, Knevels E, Schmidt T, Farrar CT, Vakoc BJ, Mohan N, Chung E, Roberge S, Peterson T, Bais C, Zhelyazkova BH, Yip S, Hasselblatt M, Rossig C, Niemeyer E, Ferrara N, Klagsbrun M, Duda DG, Fukumura D, Xu L, Carmeliet P, Jain RK. Targeting placental growth factor/neuropilin 1 pathway inhibits growth and spread of medulloblastoma. Cell. 2013 Feb 28; 152(5):1065-76. PMID: 23452854.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  59. Huang Y, Goel S, Duda DG, Fukumura D, Jain RK. Vascular normalization as an emerging strategy to enhance cancer immunotherapy. Cancer Res. 2013 May 15; 73(10):2943-8. PMID: 23440426.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  60. Chen O, Zhao J, Chauhan VP, Cui J, Wong C, Harris DK, Wei H, Han HS, Fukumura D, Jain RK, Bawendi MG. Compact high-quality CdSe-CdS core-shell nanocrystals with narrow emission linewidths and suppressed blinking. Nat Mater. 2013 May; 12(5):445-51. PMID: 23377294.
    Citations: 57     Fields:    
  61. Jain RK, Munn LL, Fukumura D. Lung window preparation in mice. Cold Spring Harb Protoc. 2013 Jan 01; 2013(1). PMID: 23282642.
    Citations:    Fields:    Translation:Animals
  62. Han HS, Martin JD, Lee J, Harris DK, Fukumura D, Jain RK, Bawendi M. Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo. Angew Chem Int Ed Engl. 2013 Jan 28; 52(5):1414-9. PMID: 23255143.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  63. Jain RK, Munn LL, Fukumura D. Liver tumor preparation in mice. Cold Spring Harb Protoc. 2012 Dec 01; 2012(12). PMID: 23209146.
    Citations: 1     Fields:    Translation:Animals
  64. Jain RK, Munn LL, Fukumura D. Pancreatic tumor preparation in mice. Cold Spring Harb Protoc. 2012 Dec 01; 2012(12). PMID: 23209145.
    Citations:    Fields:    Translation:Animals
  65. Jain RK, Munn LL, Fukumura D. Lymphangiography of the mouse tail. Cold Spring Harb Protoc. 2012 Nov 01; 2012(11):1177-8. PMID: 23118364.
    Citations: 1     Fields:    Translation:Animals
  66. Jain RK, Munn LL, Fukumura D. Lymphangiography of the mouse ear. Cold Spring Harb Protoc. 2012 Nov 01; 2012(11):1179-80. PMID: 23118365.
    Citations: 3     Fields:    Translation:Animals
  67. Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK. Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):E3119-27. PMID: 23071298.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  68. Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17561-6. PMID: 23045683.
    Citations: 147     Fields:    Translation:HumansAnimals
  69. Jain RK, Munn LL, Fukumura D. Mammary fat pad chamber preparation in mice. Cold Spring Harb Protoc. 2012 Oct 01; 2012(10):1113-4. PMID: 23028075.
    Citations:    Fields:    Translation:Animals
  70. Jain RK, Munn LL, Fukumura D. Mammary fat pad tumor preparation in mice. Cold Spring Harb Protoc. 2012 Oct 01; 2012(10):1115-6. PMID: 23028076.
    Citations: 5     Fields:    Translation:Animals
  71. Jain RK, Munn LL, Fukumura D. Corneal pocket assay in rabbits. Cold Spring Harb Protoc. 2012 Sep 01; 2012(9):1017-8. PMID: 22949714.
    Citations:    Fields:    Translation:Animals
  72. Stylianopoulos T, Soteriou K, Fukumura D, Jain RK. Cationic nanoparticles have superior transvascular flux into solid tumors: insights from a mathematical model. Ann Biomed Eng. 2013 Jan; 41(1):68-77. PMID: 22855118.
    Citations: 17     Fields:    
  73. Jain RK, Munn LL, Fukumura D. Rabbit ear chambers. Cold Spring Harb Protoc. 2012 Jul 01; 2012(7):813-14. PMID: 22753607.
    Citations:    Fields:    Translation:Animals
  74. Goel S, Fukumura D, Jain RK. Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):E1214. PMID: 22550180.
    Citations: 13     Fields:    Translation:HumansAnimals
  75. Chauhan VP, Stylianopoulos T, Martin JD, Popovic Z, Chen O, Kamoun WS, Bawendi MG, Fukumura D, Jain RK. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nat Nanotechnol. 2012 Apr 08; 7(6):383-8. PMID: 22484912.
    Citations: 172     Fields:    Translation:Animals
  76. Vakoc BJ, Fukumura D, Jain RK, Bouma BE. Cancer imaging by optical coherence tomography: preclinical progress and clinical potential. Nat Rev Cancer. 2012 Apr 05; 12(5):363-8. PMID: 22475930.
    Citations: 46     Fields:    Translation:HumansAnimals
  77. Duyverman AM, Steller EJ, Fukumura D, Jain RK, Duda DG. Studying primary tumor-associated fibroblast involvement in cancer metastasis in mice. Nat Protoc. 2012 Mar 22; 7(4):756-62. PMID: 22441294.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  78. Duyverman AM, Kohno M, Roberge S, Fukumura D, Duda DG, Jain RK. An isolated tumor perfusion model in mice. Nat Protoc. 2012 Mar 22; 7(4):749-55. PMID: 22441293.
    Citations: 4     Fields:    Translation:AnimalsCells
  79. Duyverman AM, Kohno M, Duda DG, Jain RK, Fukumura D. A transient parabiosis skin transplantation model in mice. Nat Protoc. 2012 Mar 22; 7(4):763-70. PMID: 22441295.
    Citations: 7     Fields:    Translation:AnimalsCells
  80. Kirkpatrick ND, Chung E, Cook DC, Han X, Gruionu G, Liao S, Munn LL, Padera TP, Fukumura D, Jain RK. Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment. Intravital. 2012; 1(1). PMID: 24353926.
    Citations: 10     
  81. Stylianopoulos T, Wong C, Bawendi MG, Jain RK, Fukumura D. Multistage nanoparticles for improved delivery into tumor tissue. Methods Enzymol. 2012; 508:109-30. PMID: 22449923.
    Citations: 7     Fields:    Translation:Animals
  82. Liao S, Cheng G, Conner DA, Huang Y, Kucherlapati RS, Munn LL, Ruddle NH, Jain RK, Fukumura D, Padera TP. Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18784-9. PMID: 22065738.
    Citations: 80     Fields:    Translation:AnimalsCells
  83. Chauhan VP, Popovic Z, Chen O, Cui J, Fukumura D, Bawendi MG, Jain RK. Fluorescent nanorods and nanospheres for real-time in vivo probing of nanoparticle shape-dependent tumor penetration. Angew Chem Int Ed Engl. 2011 Nov 25; 50(48):11417-20. PMID: 22113800.
    Citations: 65     Fields:    Translation:Animals
  84. Cheng G, Liao S, Kit Wong H, Lacorre DA, di Tomaso E, Au P, Fukumura D, Jain RK, Munn LL. Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis. Blood. 2011 Oct 27; 118(17):4740-9. PMID: 21835951.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  85. Goel S, Duda DG, Xu L, Munn LL, Boucher Y, Fukumura D, Jain RK. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 2011 Jul; 91(3):1071-121. PMID: 21742796.
    Citations: 349     Fields:    Translation:HumansAnimals
  86. Huang P, Westmoreland SV, Jain RK, Fukumura D. Spontaneous nonthymic tumors in SCID mice. Comp Med. 2011 Jun; 61(3):227-34. PMID: 21819692.
    Citations: 8     Fields:    Translation:Animals
  87. Eichler AF, Chung E, Kodack DP, Loeffler JS, Fukumura D, Jain RK. The biology of brain metastases-translation to new therapies. Nat Rev Clin Oncol. 2011 Jun; 8(6):344-56. PMID: 21487419.
    Citations: 112     Fields:    Translation:HumansAnimals
  88. Liu J, Liao S, Huang Y, Samuel R, Shi T, Naxerova K, Huang P, Kamoun W, Jain RK, Fukumura D, Xu L. PDGF-D improves drug delivery and efficacy via vascular normalization, but promotes lymphatic metastasis by activating CXCR4 in breast cancer. Clin Cancer Res. 2011 Jun 01; 17(11):3638-48. PMID: 21459800.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  89. Duda DG, Kozin SV, Kirkpatrick ND, Xu L, Fukumura D, Jain RK. CXCL12 (SDF1alpha)-CXCR4/CXCR7 pathway inhibition: an emerging sensitizer for anticancer therapies? Clin Cancer Res. 2011 Apr 15; 17(8):2074-80. PMID: 21349998.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  90. Hiratsuka S, Goel S, Kamoun WS, Maru Y, Fukumura D, Duda DG, Jain RK. Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3725-30. PMID: 21321210.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  91. Wong C, Stylianopoulos T, Cui J, Martin J, Chauhan VP, Jiang W, Popovic Z, Jain RK, Bawendi MG, Fukumura D. Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2426-31. PMID: 21245339.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  92. Baish JW, Stylianopoulos T, Lanning RM, Kamoun WS, Fukumura D, Munn LL, Jain RK. Scaling rules for diffusive drug delivery in tumor and normal tissues. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1799-803. PMID: 21224417.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  93. Hiratsuka S, Duda DG, Huang Y, Goel S, Sugiyama T, Nagasawa T, Fukumura D, Jain RK. C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):302-7. PMID: 21173223.
    Citations: 35     Fields:    Translation:AnimalsCells
  94. Duda DG, Duyverman AM, Kohno M, Snuderl M, Steller EJ, Fukumura D, Jain RK. Malignant cells facilitate lung metastasis by bringing their own soil. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21677-82. PMID: 21098274.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  95. Popovic Z, Liu W, Chauhan VP, Lee J, Wong C, Greytak AB, Insin N, Nocera DG, Fukumura D, Jain RK, Bawendi MG. A nanoparticle size series for in vivo fluorescence imaging. Angew Chem Int Ed Engl. 2010 Nov 08; 49(46):8649-52. PMID: 20886481.
    Citations: 62     Fields:    Translation:Animals
  96. Stylianopoulos T, Poh MZ, Insin N, Bawendi MG, Fukumura D, Munn LL, Jain RK. Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions. Biophys J. 2010 Sep 08; 99(5):1342-9. PMID: 20816045.
    Citations: 51     Fields:    Translation:AnimalsCells
  97. Brown E, Munn LL, Fukumura D, Jain RK. In vivo imaging of tumors. Cold Spring Harb Protoc. 2010 Jul 01; 2010(7):pdb.prot5452. PMID: 20647356.
    Citations: 22     Fields:    Translation:HumansAnimals
  98. Kamoun WS, Chae SS, Lacorre DA, Tyrrell JA, Mitre M, Gillissen MA, Fukumura D, Jain RK, Munn LL. Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks. Nat Methods. 2010 Aug; 7(8):655-60. PMID: 20581828.
    Citations: 58     Fields:    Translation:AnimalsCells
  99. Chae SS, Kamoun WS, Farrar CT, Kirkpatrick ND, Niemeyer E, de Graaf AM, Sorensen AG, Munn LL, Jain RK, Fukumura D. Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Clin Cancer Res. 2010 Jul 15; 16(14):3618-27. PMID: 20501615.
    Citations: 37     Fields:    Translation:HumansAnimals
  100. Fukumura D, Duda DG, Munn LL, Jain RK. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation. 2010 Apr; 17(3):206-25. PMID: 20374484.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  101. Kim P, Chung E, Yamashita H, Hung KE, Mizoguchi A, Kucherlapati R, Fukumura D, Jain RK, Yun SH. In vivo wide-area cellular imaging by side-view endomicroscopy. Nat Methods. 2010 Apr; 7(4):303-5. PMID: 20228814.
    Citations: 51     Fields:    Translation:Animals
  102. Liu W, Greytak AB, Lee J, Wong CR, Park J, Marshall LF, Jiang W, Curtin PN, Ting AY, Nocera DG, Fukumura D, Jain RK, Bawendi MG. Compact biocompatible quantum dots via RAFT-mediated synthesis of imidazole-based random copolymer ligand. J Am Chem Soc. 2010 Jan 20; 132(2):472-83. PMID: 20025223.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  103. Allen PM, Liu W, Chauhan VP, Lee J, Ting AY, Fukumura D, Jain RK, Bawendi MG. InAs(ZnCdS) quantum dots optimized for biological imaging in the near-infrared. J Am Chem Soc. 2010 Jan 20; 132(2):470-1. PMID: 20025222.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  104. Choi B, Bouma B, Fukumura D, Jain RK. Optical methods in vascular biology and medicine. J Biomed Opt. 2010 Jan-Feb; 15(1):011001. PMID: 20210426.
    Citations:    Fields:    Translation:HumansAnimals
  105. Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK. Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases. PLoS One. 2009 Dec 15; 4(12):e8316. PMID: 20016816.
    Citations: 34     Fields:    Translation:AnimalsCells
  106. Dawson MR, Duda DG, Chae SS, Fukumura D, Jain RK. VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation. PLoS One. 2009 Sep 18; 4(9):e6525. PMID: 19763275.
    Citations: 20     Fields:    Translation:AnimalsCells
  107. Dawson MR, Duda DG, Fukumura D, Jain RK. VEGFR1-activity-independent metastasis formation. Nature. 2009 Sep 17; 461(7262):E4; discussion E5. PMID: 19759568.
    Citations: 28     Fields:    Translation:AnimalsCells
  108. Vakoc BJ, Lanning RM, Tyrrell JA, Padera TP, Bartlett LA, Stylianopoulos T, Munn LL, Tearney GJ, Fukumura D, Jain RK, Bouma BE. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med. 2009 Oct; 15(10):1219-23. PMID: 19749772.
    Citations: 207     Fields:    Translation:HumansAnimals
  109. Kumar AT, Chung E, Raymond SB, van de Water JA, Shah K, Fukumura D, Jain RK, Bacskai BJ, Boas DA. Feasibility of in vivo imaging of fluorescent proteins using lifetime contrast. Opt Lett. 2009 Jul 01; 34(13):2066-8. PMID: 19572001.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  110. Au P, Tam J, Duda DG, Lin PC, Munn LL, Fukumura D, Jain RK. Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo. Am J Pathol. 2009 Jul; 175(1):294-302. PMID: 19477947.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  111. Luong MX, Tam J, Lin Q, Hagendoorn J, Moore KJ, Padera TP, Seed B, Fukumura D, Kucherlapati R, Jain RK. Lack of lymphatic vessel phenotype in LYVE-1/CD44 double knockout mice. J Cell Physiol. 2009 May; 219(2):430-7. PMID: 19170073.
    Citations: 12     Fields:    Translation:AnimalsCells
  112. Tam J, Duda DG, Perentes JY, Quadri RS, Fukumura D, Jain RK. Blockade of VEGFR2 and not VEGFR1 can limit diet-induced fat tissue expansion: role of local versus bone marrow-derived endothelial cells. PLoS One. 2009; 4(3):e4974. PMID: 19333381.
    Citations: 26     Fields:    Translation:AnimalsCells
  113. Kamoun WS, Ley CD, Farrar CT, Duyverman AM, Lahdenranta J, Lacorre DA, Batchelor TT, di Tomaso E, Duda DG, Munn LL, Fukumura D, Sorensen AG, Jain RK. Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol. 2009 May 20; 27(15):2542-52. PMID: 19332720.
    Citations: 115     Fields:    Translation:HumansAnimals
  114. Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D. Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Res. 2009 Apr 01; 69(7):2801-8. PMID: 19318557.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  115. Tam J, Fukumura D, Jain RK. A mathematical model of murine metabolic regulation by leptin: energy balance and defense of a stable body weight. Cell Metab. 2009 Jan 07; 9(1):52-63. PMID: 19117546.
    Citations: 18     Fields:    Translation:Animals
  116. Padera TP, Kuo AH, Hoshida T, Liao S, Lobo J, Kozak KR, Fukumura D, Jain RK. Differential response of primary tumor versus lymphatic metastasis to VEGFR-2 and VEGFR-3 kinase inhibitors cediranib and vandetanib. Mol Cancer Ther. 2008 Aug; 7(8):2272-9. PMID: 18687659.
    Citations: 39     Fields:    Translation:AnimalsCells
  117. Fukumura D, Jain RK. Imaging angiogenesis and the microenvironment. APMIS. 2008 Jul-Aug; 116(7-8):695-715. PMID: 18834413.
    Citations: 55     Fields:    Translation:HumansAnimals
  118. Huang P, Duda DG, Jain RK, Fukumura D. Histopathologic findings and establishment of novel tumor lines from spontaneous tumors in FVB/N mice. Comp Med. 2008 Jun; 58(3):253-63. PMID: 18589867.
    Citations: 11     Fields:    Translation:AnimalsCells
  119. Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D. Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med. 2008 Mar; 14(3):255-7. PMID: 18278052.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  120. Au P, Tam J, Fukumura D, Jain RK. Bone marrow-derived mesenchymal stem cells facilitate engineering of long-lasting functional vasculature. Blood. 2008 May 01; 111(9):4551-8. PMID: 18256324.
    Citations: 157     Fields:    Translation:HumansCells
  121. Jain RK, Lahdenranta J, Fukumura D. Targeting PDGF signaling in carcinoma-associated fibroblasts controls cervical cancer in mouse model. PLoS Med. 2008 Jan 29; 5(1):e24. PMID: 18232729.
    Citations: 8     Fields:    Translation:AnimalsCells
  122. Au P, Daheron LM, Duda DG, Cohen KS, Tyrrell JA, Lanning RM, Fukumura D, Scadden DT, Jain RK. Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels. Blood. 2008 Feb 01; 111(3):1302-5. PMID: 17993613.
    Citations: 99     Fields:    Translation:HumansCells
  123. Fukumura D, Jain RK. Tumor microenvironment abnormalities: causes, consequences, and strategies to normalize. J Cell Biochem. 2007 Jul 01; 101(4):937-49. PMID: 17171643.
    Citations: 138     Fields:    Translation:HumansAnimals
  124. Fukumura D, Jain RK. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvasc Res. 2007 Sep-Nov; 74(2-3):72-84. PMID: 17560615.
    Citations: 191     Fields:    Translation:HumansAnimals
  125. Padera TP, Ancukiewicz M, Hoshida T, Fukumura D, Jain RK. Anti-VEGFR-3 therapy and lymph node metastasis [corrected]. Cancer Res. 2007 May 15; 67(10):5055; author reply 5056. PMID: 17510438.
    Citations:    Fields:    Translation:Animals
  126. Ogawa K, Boucher Y, Kashiwagi S, Fukumura D, Chen D, Gerweck LE. Influence of tumor cell and stroma sensitivity on tumor response to radiation. Cancer Res. 2007 May 01; 67(9):4016-21. PMID: 17483312.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  127. Wang ZZ, Au P, Chen T, Shao Y, Daheron LM, Bai H, Arzigian M, Fukumura D, Jain RK, Scadden DT. Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nat Biotechnol. 2007 Mar; 25(3):317-8. PMID: 17322871.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  128. Au P, Tam J, Fukumura D, Jain RK. Small blood vessel engineering. Methods Mol Med. 2007; 140:183-95. PMID: 18085210.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  129. Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP, Jain RK. Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Res. 2006 Aug 15; 66(16):8065-75. PMID: 16912183.
    Citations: 116     Fields:    Translation:AnimalsCells
  130. Cochran DM, Fukumura D, Ancukiewicz M, Carmeliet P, Jain RK. Evolution of oxygen and glucose concentration profiles in a tissue-mimetic culture system of embryonic stem cells. Ann Biomed Eng. 2006 Aug; 34(8):1247-58. PMID: 16832606.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  131. Fukumura D, Kashiwagi S, Jain RK. The role of nitric oxide in tumour progression. Nat Rev Cancer. 2006 Jul; 6(7):521-34. PMID: 16794635.
    Citations: 208     Fields:    Translation:HumansAnimalsCells
  132. Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D. Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models. Cancer Res. 2006 Apr 15; 66(8):3971-7. PMID: 16618713.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  133. Hagendoorn J, Tong R, Fukumura D, Lin Q, Lobo J, Padera TP, Xu L, Kucherlapati R, Jain RK. Onset of abnormal blood and lymphatic vessel function and interstitial hypertension in early stages of carcinogenesis. Cancer Res. 2006 Apr 01; 66(7):3360-4. PMID: 16585153.
    Citations: 43     Fields:    Translation:AnimalsCells
  134. Duda DG, Cohen KS, Kozin SV, Perentes JY, Fukumura D, Scadden DT, Jain RK. Evidence for incorporation of bone marrow-derived endothelial cells into perfused blood vessels in tumors. Blood. 2006 Apr 01; 107(7):2774-6. PMID: 16339405.
    Citations: 47     Fields:    Translation:HumansCells
  135. Acker T, Diez-Juan A, Aragones J, Tjwa M, Brusselmans K, Moons L, Fukumura D, Moreno-Murciano MP, Herbert JM, Burger A, Riedel J, Elvert G, Flamme I, Maxwell PH, Collen D, Dewerchin M, Jain RK, Plate KH, Carmeliet P. Genetic evidence for a tumor suppressor role of HIF-2alpha. Cancer Cell. 2005 Aug; 8(2):131-41. PMID: 16098466.
    Citations: 61     Fields:    Translation:HumansAnimals
  136. Hagendoorn J, Padera TP, Fukumura D, Jain RK. Molecular regulation of microlymphatic formation and function: role of nitric oxide. Trends Cardiovasc Med. 2005 Jul; 15(5):169-73. PMID: 16165013.
    Citations: 6     Fields:    Translation:HumansAnimals
  137. Jain RK, Au P, Tam J, Duda DG, Fukumura D. Engineering vascularized tissue. Nat Biotechnol. 2005 Jul; 23(7):821-3. PMID: 16003365.
    Citations: 131     Fields:    Translation:HumansAnimals
  138. Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. J Clin Invest. 2005 Jul; 115(7):1816-27. PMID: 15951843.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  139. Huang P, McKee TD, Jain RK, Fukumura D. Green fluorescent protein (GFP)-expressing tumor model derived from a spontaneous osteosarcoma in a vascular endothelial growth factor (VEGF)-GFP transgenic mouse. Comp Med. 2005 Jun; 55(3):236-43. PMID: 16089171.
    Citations: 6     Fields:    Translation:AnimalsCells
  140. Stroh M, Zimmer JP, Duda DG, Levchenko TS, Cohen KS, Brown EB, Scadden DT, Torchilin VP, Bawendi MG, Fukumura D, Jain RK. Quantum dots spectrally distinguish multiple species within the tumor milieu in vivo. Nat Med. 2005 Jun; 11(6):678-82. PMID: 15880117.
    Citations: 85     Fields:    Translation:AnimalsCells
  141. Winkler F, Kozin SV, Tong RT, Chae SS, Booth MF, Garkavtsev I, Xu L, Hicklin DJ, Fukumura D, di Tomaso E, Munn LL, Jain RK. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 2004 Dec; 6(6):553-63. PMID: 15607960.
    Citations: 383     Fields:    Translation:HumansAnimalsCells
  142. Duda DG, Fukumura D, Munn LL, Booth MF, Brown EB, Huang P, Seed B, Jain RK. Differential transplantability of tumor-associated stromal cells. Cancer Res. 2004 Sep 01; 64(17):5920-4. PMID: 15342367.
    Citations: 24     Fields:    Translation:AnimalsCells
  143. Isaka N, Padera TP, Hagendoorn J, Fukumura D, Jain RK. Peritumor lymphatics induced by vascular endothelial growth factor-C exhibit abnormal function. Cancer Res. 2004 Jul 01; 64(13):4400-4. PMID: 15231646.
    Citations: 46     Fields:    Translation:Animals
  144. Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK. Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res. 2004 Jul 23; 95(2):204-9. PMID: 15192027.
    Citations: 35     Fields:    Translation:Animals
  145. Gohongi T, Todoroki T, Fukumura D, Jain RK. Influence of the site of human gallbladder xenograft (Mz-ChA-1) on angiogenesis at the distant site. Oncol Rep. 2004 Apr; 11(4):803-7. PMID: 15010876.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  146. Duda DG, Fukumura D, Jain RK. Role of eNOS in neovascularization: NO for endothelial progenitor cells. Trends Mol Med. 2004 Apr; 10(4):143-5. PMID: 15162796.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  147. Koike N, Fukumura D, Gralla O, Au P, Schechner JS, Jain RK. Tissue engineering: creation of long-lasting blood vessels. Nature. 2004 Mar 11; 428(6979):138-9. PMID: 15014486.
    Citations: 166     Fields:    Translation:HumansAnimalsCells
  148. Xu L, Pathak PS, Fukumura D. Hypoxia-induced activation of p38 mitogen-activated protein kinase and phosphatidylinositol 3'-kinase signaling pathways contributes to expression of interleukin 8 in human ovarian carcinoma cells. Clin Cancer Res. 2004 Jan 15; 10(2):701-7. PMID: 14760093.
    Citations: 27     Fields:    Translation:HumansCells
  149. Fukumura D, Ushiyama A, Duda DG, Xu L, Tam J, Krishna V, Chatterjee K, Garkavtsev I, Jain RK. Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. Circ Res. 2003 Oct 31; 93(9):e88-97. PMID: 14525808.
    Citations: 76     Fields:    Translation:AnimalsCells
  150. Bockhorn M, Tsuzuki Y, Xu L, Frilling A, Broelsch CE, Fukumura D. Differential vascular and transcriptional responses to anti-vascular endothelial growth factor antibody in orthotopic human pancreatic cancer xenografts. Clin Cancer Res. 2003 Sep 15; 9(11):4221-6. PMID: 14519649.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  151. Forbes NS, Munn LL, Fukumura D, Jain RK. Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res. 2003 Sep 01; 63(17):5188-93. PMID: 14500342.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  152. Dolmans DE, Fukumura D, Jain RK. Photodynamic therapy for cancer. Nat Rev Cancer. 2003 May; 3(5):380-7. PMID: 12724736.
    Citations: 455     Fields:    Translation:Humans
  153. Izumi Y, di Tomaso E, Hooper A, Huang P, Huber J, Hicklin DJ, Fukumura D, Jain RK, Suit HD. Responses to antiangiogenesis treatment of spontaneous autochthonous tumors and their isografts. Cancer Res. 2003 Feb 15; 63(4):747-51. PMID: 12591719.
    Citations: 8     Fields:    Translation:Animals
  154. Campbell RB, Fukumura D, Brown EB, Mazzola LM, Izumi Y, Jain RK, Torchilin VP, Munn LL. Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res. 2002 Dec 01; 62(23):6831-6. PMID: 12460895.
    Citations: 82     Fields:    Translation:HumansAnimals
  155. Dolmans DE, Kadambi A, Hill JS, Flores KR, Gerber JN, Walker JP, Borel Rinkes IH, Jain RK, Fukumura D. Targeting tumor vasculature and cancer cells in orthotopic breast tumor by fractionated photosensitizer dosing photodynamic therapy. Cancer Res. 2002 Aug 01; 62(15):4289-94. PMID: 12154031.
    Citations: 13     Fields:    Translation:Animals
  156. Jain RK, Munn LL, Fukumura D. Dissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer. 2002 Apr; 2(4):266-76. PMID: 12001988.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  157. Monsky WL, Mouta Carreira C, Tsuzuki Y, Gohongi T, Fukumura D, Jain RK. Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors. Clin Cancer Res. 2002 Apr; 8(4):1008-13. PMID: 11948107.
    Citations: 41     Fields:    Translation:HumansAnimals
  158. Dolmans DE, Kadambi A, Hill JS, Waters CA, Robinson BC, Walker JP, Fukumura D, Jain RK. Vascular accumulation of a novel photosensitizer, MV6401, causes selective thrombosis in tumor vessels after photodynamic therapy. Cancer Res. 2002 Apr 01; 62(7):2151-6. PMID: 11929837.
    Citations: 24     Fields:    Translation:Animals
  159. Izumi Y, Xu L, di Tomaso E, Fukumura D, Jain RK. Tumour biology: herceptin acts as an anti-angiogenic cocktail. Nature. 2002 Mar 21; 416(6878):279-80. PMID: 11907566.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  160. Xu L, Fukumura D, Jain RK. Acidic extracellular pH induces vascular endothelial growth factor (VEGF) in human glioblastoma cells via ERK1/2 MAPK signaling pathway: mechanism of low pH-induced VEGF. J Biol Chem. 2002 Mar 29; 277(13):11368-74. PMID: 11741977.
    Citations: 68     Fields:    Translation:HumansCells
  161. Tsuzuki Y, Mouta Carreira C, Bockhorn M, Xu L, Jain RK, Fukumura D. Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation. Lab Invest. 2001 Oct; 81(10):1439-51. PMID: 11598156.
    Citations: 30     Fields:    Translation:Animals
  162. Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res. 2001 Aug 15; 61(16):6020-4. PMID: 11507045.
    Citations: 103     Fields:    Translation:Cells
  163. Brown EB, Campbell RB, Tsuzuki Y, Xu L, Carmeliet P, Fukumura D, Jain RK. In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy. Nat Med. 2001 Jul; 7(7):864-8. PMID: 11433354.
    Citations: 155     Fields:    Translation:Cells
  164. Kadambi A, Mouta Carreira C, Yun CO, Padera TP, Dolmans DE, Carmeliet P, Fukumura D, Jain RK. Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Cancer Res. 2001 Mar 15; 61(6):2404-8. PMID: 11289105.
    Citations: 20     Fields:    Translation:AnimalsCells
  165. Fukumura D, Gohongi T, Kadambi A, Izumi Y, Ang J, Yun CO, Buerk DG, Huang PL, Jain RK. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability. Proc Natl Acad Sci U S A. 2001 Feb 27; 98(5):2604-9. PMID: 11226286.
    Citations: 225     Fields:    Translation:Animals
  166. Tsuzuki Y, Fukumura D, Oosthuyse B, Koike C, Carmeliet P, Jain RK. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha--> hypoxia response element--> VEGF cascade differentially regulates vascular response and growth rate in tumors. Cancer Res. 2000 Nov 15; 60(22):6248-52. PMID: 11103778.
    Citations: 61     Fields:    Translation:AnimalsCells
  167. Hansen-Algenstaedt N, Stoll BR, Padera TP, Dolmans DE, Hicklin DJ, Fukumura D, Jain RK. Tumor oxygenation in hormone-dependent tumors during vascular endothelial growth factor receptor-2 blockade, hormone ablation, and chemotherapy. Cancer Res. 2000 Aug 15; 60(16):4556-60. PMID: 10969807.
    Citations: 19     Fields:    Translation:Animals
  168. Hartford AC, Gohongi T, Fukumura D, Jain RK. Irradiation of a primary tumor, unlike surgical removal, enhances angiogenesis suppression at a distal site: potential role of host-tumor interaction. Cancer Res. 2000 Apr 15; 60(8):2128-31. PMID: 10786673.
    Citations: 9