Harvard Catalyst Profiles

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Stephen J. Elledge, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA234600 (ELLEDGE, STEPHEN J) Jan 1, 2019 - Dec 31, 2023
    NIH/NCI
    Analysis of the Mammalian DNA Damage Response
    Role: Principal Investigator
  2. U01CA199252 (HAIGIS, KEVIN MICHAEL) Sep 25, 2015 - Aug 31, 2019
    NIH/NCI
    A multi-faceted approach to identifying K-Ras synthetic lethal relationships
    Role: Principal Investigator
  3. U24AI118633 (LARMAN, HARRY BENJAMIN) Jun 22, 2015 - May 31, 2020
    NIH/NIAID
    Development of Highly Multiplex Antigen Specificity Assays
    Role: Principal Investigator
  4. R33CA140039 (ELLEDGE, STEPHEN J) Aug 1, 2009 - Jul 31, 2013
    NIH/NCI
    A multiplex genome-wide shRNA screening platform for cancer-lethal gene discovery
    Role: Principal Investigator
  5. U19AI067751 (D'ANDREA, ALAN DAVID) Aug 31, 2005 - Jul 31, 2011
    NIH/NIAID
    Centers for Medical Countermeasures Against Radiation
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K. MAPK pathway suppression unmasks latent DNA repair defects and confers a chemical synthetic vulnerability in BRAF, NRAS, and NF1 mutant melanomas. Cancer Discov. 2019 Feb 01. PMID: 30709805.
    Citations:    Fields:    
  2. Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019 Jan 23. PMID: 30686591.
    Citations:    Fields:    
  3. Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY. A Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach. J Neurosci. 2018 Oct 24; 38(43):9286-9301. PMID: 30249792.
    Citations:    Fields:    
  4. Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras MN, Leung MC, Mathew LS, Boisson B, Zhang SY, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L, Zhang Q, Marr N, Crow YJ, Su HC, Casanova JL. Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency. J Exp Med. 2018 Oct 01; 215(10):2567-2585. PMID: 30143481.
    Citations: 1     Fields:    
  5. Liao S, Maertens O, Cichowski K, Elledge SJ. Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. Genes Dev. 2018 09 01; 32(17-18):1188-1200. PMID: 30135075.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HS. C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. Mol Cell. 2018 05 17; 70(4):602-613.e3. PMID: 29775578.
    Citations: 2     Fields:    
  7. Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ. The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons. Cell. 2018 Jun 14; 173(7):1622-1635.e14. PMID: 29779948.
    Citations:    Fields:    
  8. Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. 2018 04 05; 173(2):499-514.e23. PMID: 29576454.
    Citations: 4     Fields:    
  9. Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 25; 172(3):629-631. PMID: 29373832.
    Citations:    Fields:    
  10. Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 11; 172(1-2):106-120.e21. PMID: 29249356.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ. Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes Dev. 2017 11 15; 31(22):2310. PMID: 29284711.
    Citations:    Fields:    
  12. Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ. Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes Dev. 2017 10 01; 31(19):1933-1938. PMID: 29089421.
    Citations: 1     Fields:    Translation:HumansCells
  13. Watson EV, Elledge SJ. Aneuploidy Police Detect Chromosomal Imbalance Triggering Immune Crackdown! Trends Genet. 2017 10; 33(10):662-664. PMID: 28800914.
    Citations: 1     Fields:    Translation:HumansCells
  14. Shah AA, Rosen A, Hummers LK, Wigley FM, Xu G, Elledge SJ, Casciola-Rosen L. Reply. Arthritis Rheumatol. 2017 Sep; 69(9):1915-1916. PMID: 28454209.
    Citations:    Fields:    
  15. Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Rep. 2017 07 11; 20(2):427-438. PMID: 28700943.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  16. Naxerova K, Reiter JG, Brachtel E, Lennerz JK, van de Wetering M, Rowan A, Cai T, Clevers H, Swanton C, Nowak MA, Elledge SJ, Jain RK. Origins of lymphatic and distant metastases in human colorectal cancer. Science. 2017 Jul 07; 357(6346):55-60. PMID: 28684519.
    Citations: 24     Fields:    Translation:Humans
  17. Shah AA, Xu G, Rosen A, Hummers LK, Wigley FM, Elledge SJ, Casciola-Rosen L. Brief Report: Anti-RNPC-3 Antibodies As a Marker of Cancer-Associated Scleroderma. Arthritis Rheumatol. 2017 06; 69(6):1306-1312. PMID: 28217959.
    Citations: 4     Fields:    Translation:Humans
  18. Davoli T, Uno H, Wooten EC, Elledge SJ. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017 01 20; 355(6322). PMID: 28104840.
    Citations: 49     Fields:    Translation:HumansCells
  19. Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ. A genetic interaction analysis identifies cancer drivers that modify EGFR dependency. Genes Dev. 2017 01 15; 31(2):184-196. PMID: 28167502.
    Citations: 9     Fields:    Translation:HumansCells
  20. Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ. Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes Dev. 2016 12 15; 30(24):2684-2695. PMID: 28087713.
    Citations: 3     Fields:    Translation:HumansAnimalsCells