Harvard Catalyst Profiles

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Stephen J. Elledge, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA234600 (ELLEDGE, STEPHEN J) Jan 1, 2019 - Dec 31, 2023
    NIH/NCI
    Analysis of the Mammalian DNA Damage Response
    Role: Principal Investigator
  2. U01CA199252 (HAIGIS, KEVIN MICHAEL) Sep 25, 2015 - Aug 31, 2019
    NIH/NCI
    A multi-faceted approach to identifying K-Ras synthetic lethal relationships
    Role: Principal Investigator
  3. U24AI118633 (LARMAN, HARRY BENJAMIN) Jun 22, 2015 - May 31, 2020
    NIH/NIAID
    Development of Highly Multiplex Antigen Specificity Assays
    Role: Principal Investigator
  4. R33CA140039 (ELLEDGE, STEPHEN J) Aug 1, 2009 - Jul 31, 2013
    NIH/NCI
    A multiplex genome-wide shRNA screening platform for cancer-lethal gene discovery
    Role: Principal Investigator
  5. U19AI067751 (D'ANDREA, ALAN DAVID) Aug 31, 2005 - Jul 31, 2011
    NIH/NIAID
    Centers for Medical Countermeasures Against Radiation
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Isnard P, Kula T, Avettand Fenoel V, Anglicheau D, Terzi F, Legendre C, Elledge SJ, Canaud G. Temporal virus serological profiling of kidney graft recipients using VirScan. Proc Natl Acad Sci U S A. 2019 May 28; 116(22):10899-10904. PMID: 31085644.
    Citations:    
  2. Eshleman SH, Laeyendecker O, Kammers K, Chen A, Sivay MV, Kottapalli S, Sie BM, Yuan T, Monaco DR, Mohan D, Wansley D, Kula T, Morrison C, Elledge SJ, Brookmeyer R, Ruczinski I, Larman HB. Comprehensive Profiling of HIV Antibody Evolution. Cell Rep. 2019 Apr 30; 27(5):1422-1433.e4. PMID: 31042470.
    Citations:    
  3. Haigis KM, Cichowski K, Elledge SJ. Tissue-specificity in cancer: The rule, not the exception. Science. 2019 Mar 15; 363(6432):1150-1151. PMID: 30872507.
    Citations:    
  4. Barber KW, Elledge SJ. Sequencer Hacking Unlocks Quantitative Protein Studies. Mol Cell. 2019 03 07; 73(5):863-865. PMID: 30849392.
    Citations:    
  5. Maertens O, Kuzmickas R, Manchester HE, Emerson CE, Gavin AG, Guild CJ, Wong TC, De Raedt T, Bowman-Colin C, Hatchi E, Garraway LA, Flaherty KT, Pathania S, Elledge SJ, Cichowski K. MAPK Pathway Suppression Unmasks Latent DNA Repair Defects and Confers a Chemical Synthetic Vulnerability in BRAF-, NRAS-, and NF1-Mutant Melanomas. Cancer Discov. 2019 Apr; 9(4):526-545. PMID: 30709805.
    Citations:    Fields:    
  6. Mengwasser KE, Adeyemi RO, Leng Y, Choi MY, Clairmont C, D'Andrea AD, Elledge SJ. Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets. Mol Cell. 2019 03 07; 73(5):885-899.e6. PMID: 30686591.
    Citations:    Fields:    
  7. Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajic A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY. A Druggable Genome Screen Identifies Modifiers of a-Synuclein Levels via a Tiered Cross-Species Validation Approach. J Neurosci. 2018 Oct 24; 38(43):9286-9301. PMID: 30249792.
    Citations:    Fields:    
  8. Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras MN, Leung MC, Mathew LS, Boisson B, Zhang SY, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L, Zhang Q, Marr N, Crow YJ, Su HC, Casanova JL. Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency. J Exp Med. 2018 Oct 01; 215(10):2567-2585. PMID: 30143481.
    Citations: 1     Fields:    
  9. Liao S, Maertens O, Cichowski K, Elledge SJ. Genetic modifiers of the BRD4-NUT dependency of NUT midline carcinoma uncovers a synergism between BETis and CDK4/6is. Genes Dev. 2018 09 01; 32(17-18):1188-1200. PMID: 30135075.
    Citations:    Fields:    Translation:HumansAnimalsCells
  10. Lin HC, Yeh CW, Chen YF, Lee TT, Hsieh PY, Rusnac DV, Lin SY, Elledge SJ, Zheng N, Yen HS. C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases. Mol Cell. 2018 05 17; 70(4):602-613.e3. PMID: 29775578.
    Citations: 2     Fields:    
  11. Koren I, Timms RT, Kula T, Xu Q, Li MZ, Elledge SJ. The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons. Cell. 2018 06 14; 173(7):1622-1635.e14. PMID: 29779948.
    Citations:    Fields:    
  12. Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ. Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns. Cell. 2018 04 05; 173(2):499-514.e23. PMID: 29576454.
    Citations: 4     Fields:    
  13. Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 25; 172(3):629-631. PMID: 29373832.
    Citations:    Fields:    
  14. Brumbaugh J, Di Stefano B, Wang X, Borkent M, Forouzmand E, Clowers KJ, Ji F, Schwarz BA, Kalocsay M, Elledge SJ, Chen Y, Sadreyev RI, Gygi SP, Hu G, Shi Y, Hochedlinger K. Nudt21 Controls Cell Fate by Connecting Alternative Polyadenylation to Chromatin Signaling. Cell. 2018 01 11; 172(1-2):106-120.e21. PMID: 29249356.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ. Corrigendum: Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes Dev. 2017 11 15; 31(22):2310. PMID: 29284711.
    Citations:    Fields:    
  16. Mazzucco AE, Smogorzewska A, Kang C, Luo J, Schlabach MR, Xu Q, Patel R, Elledge SJ. Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program. Genes Dev. 2017 10 01; 31(19):1933-1938. PMID: 29089421.
    Citations: 1     Fields:    Translation:HumansCells