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profileStephen J. Elledge, Ph.D.

TitleGregor Mendel Professor of Genetics and of Medicine
InstitutionBrigham and Women's Hospital
DepartmentGenetics
AddressHarvard Medical School
Department of Genetics, Rm 158D NRB
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-4510
Fax617/525-4500
vCardDownload vCard (login for email)
Other Positions
TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
DivisionGenetics


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U01CA199252     (HAIGIS, KEVIN MICHAEL)Sep 25, 2015 - Aug 31, 2019
NIH/NCI
A multi-faceted approach to identifying K-Ras synthetic lethal relationships
Role: Principal Investigator

U24AI118633     (LARMAN, HARRY BENJAMIN)Jun 22, 2015 - May 31, 2020
NIH/NIAID
Development of Highly Multiplex Antigen Specificity Assays
Role: Principal Investigator

R33CA140039     (ELLEDGE, STEPHEN J)Aug 1, 2009 - Jul 31, 2013
NIH/NCI
A multiplex genome-wide shRNA screening platform for cancer-lethal gene discovery
Role: Principal Investigator

U19AI067751     (D'ANDREA, ALAN DAVID)Aug 31, 2005 - Jul 31, 2011
NIH/NIAID
Centers for Medical Countermeasures Against Radiation
Role: Co-Principal Investigator

R01AG011085     (HARPER, JEFFREY W)Jan 1, 1993 - May 31, 2018
NIH/NIA
Ubiquitin-mediated proteolysis and cell cycle control
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Shah AA, Xu G, Rosen A, Hummers LK, Wigley FM, Elledge SJ, Casciola-Rosen L. Anti-RNPC3 Antibodies as a Marker of Cancer-Associated Scleroderma. Arthritis Rheumatol. 2017 Feb 19. PMID: 28217959.
    View in: PubMed
  2. Davoli T, Uno H, Wooten EC, Elledge SJ. Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy. Science. 2017 Jan 20; 355(6322). PMID: 28104840.
    View in: PubMed
  3. Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ. A genetic interaction analysis identifies cancer drivers that modify EGFR dependency. Genes Dev. 2017 Jan 15; 31(2):184-196. PMID: 28167502.
    View in: PubMed
  4. Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ. Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover. Genes Dev. 2016 Dec 15; 30(24):2684-2695. PMID: 28087713.
    View in: PubMed
  5. Xu GJ, Shah AA, Li MZ, Xu Q, Rosen A, Casciola-Rosen L, Elledge SJ. Systematic autoantigen analysis identifies a distinct subtype of scleroderma with coincident cancer. Proc Natl Acad Sci U S A. 2016 Nov 22; 113(47):E7526-E7534. PMID: 27821747.
    View in: PubMed
  6. Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT. Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain. Sci Rep. 2016 Oct 26; 6:35986. PMID: 27782176.
    View in: PubMed
  7. Sack LM, Davoli T, Xu Q, Li MZ, Elledge SJ. Sources of Error in Mammalian Genetic Screens. G3 (Bethesda). 2016 Sep 08; 6(9):2781-90. PMID: 27402361; PMCID: PMC5015935.
  8. Zhou C, Elia AE, Naylor ML, Dephoure N, Ballif BA, Goel G, Xu Q, Ng A, Chou DM, Xavier RJ, Gygi SP, Elledge SJ. Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks. Proc Natl Acad Sci U S A. 2016 Jun 28; 113(26):E3667-75. PMID: 27298372; PMCID: PMC4932963 [Available on 12/28/16].
  9. Willis NA, Zhou C, Elia AE, Murray JM, Carr AM, Elledge SJ, Rhind N. Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks. Proc Natl Acad Sci U S A. 2016 Jun 28; 113(26):E3676-85. PMID: 27298342; PMCID: PMC4932944 [Available on 12/28/16].
  10. Kang C, Elledge SJ. How autophagy both activates and inhibits cellular senescence. Autophagy. 2016 May 03; 12(5):898-9. PMID: 27129029; PMCID: PMC4854549 [Available on 04/29/17].
  11. Borkent M, Bennett BD, Lackford B, Bar-Nur O, Brumbaugh J, Wang L, Du Y, Fargo DC, Apostolou E, Cheloufi S, Maherali N, Elledge SJ, Hu G, Hochedlinger K. A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem Cell Reports. 2016 May 10; 6(5):704-16. PMID: 26947976; PMCID: PMC4939549.
  12. Wang Y, Xu Q, Sack L, Kang C, Elledge SJ. A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling. Genes Dev. 2016 Feb 01; 30(3):293-306. PMID: 26833729; PMCID: PMC4743059.
  13. Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LC, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, Gonzalez MG, Nguyen Q, Brass A, Elledge S, White M, Shapira S, Hacohen N, Karlas A, Meyer TF, Shales M, Gatorano A, Johnson JR, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R, Stertz S, García-Sastre A, Chanda SK. Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. Cell Host Microbe. 2015 Dec 09; 18(6):723-35. PMID: 26651948; PMCID: PMC4829074 [Available on 12/09/16].
  14. Elia AE, Wang DC, Willis NA, Boardman AP, Hajdu I, Adeyemi RO, Lowry E, Gygi SP, Scully R, Elledge SJ. RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks. Mol Cell. 2015 Oct 15; 60(2):280-93. PMID: 26474068; PMCID: PMC4609029 [Available on 10/15/16].
  15. Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science. 2015 Sep 25; 349(6255):aaa5612. PMID: 26404840; PMCID: PMC4942138.
  16. Huang H, Santoso N, Power D, Simpson S, Dieringer M, Miao H, Gurova K, Giam CZ, Elledge SJ, Zhu J. FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency. J Biol Chem. 2015 Nov 06; 290(45):27297-310. PMID: 26378236; PMCID: PMC4646377 [Available on 11/06/16].
  17. Elledge SJ. The DNA Damage Response--Self-awareness for DNA: The 2015 Albert Lasker Basic Medical Research Award. JAMA. 2015 Sep 15; 314(11):1111-2. PMID: 26348099.
    View in: PubMed
  18. Elledge SJ. Accidents and Damage Control. Cell. 2015 Sep 10; 162(6):1196-200. PMID: 26359977.
    View in: PubMed
  19. Naxerova K, Elledge SJ. Taking the brakes off telomerase. Elife. 2015 Jul 21; 4. PMID: 26194808; PMCID: PMC4507575.
  20. Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJ. Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. Science. 2015 Jun 05; 348(6239):aaa0698. PMID: 26045439; PMCID: PMC4844011.
  21. Elia AE, Boardman AP, Wang DC, Huttlin EL, Everley RA, Dephoure N, Zhou C, Koren I, Gygi SP, Elledge SJ. Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. Mol Cell. 2015 Sep 03; 59(5):867-81. PMID: 26051181; PMCID: PMC4560960.
  22. Izhar L, Adamson B, Ciccia A, Lewis J, Pontano-Vaites L, Leng Y, Liang AC, Westbrook TF, Harper JW, Elledge SJ. A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Rep. 2015 Jun 09; 11(9):1486-500. PMID: 26004182; PMCID: PMC4464939.
  23. Gao J, Kim HM, Elia AE, Elledge SJ, Colaiácovo MP. NatB domain-containing CRA-1 antagonizes hydrolase ACER-1 linking acetyl-CoA metabolism to the initiation of recombination during C. elegans meiosis. PLoS Genet. 2015 Mar; 11(3):e1005029. PMID: 25768301; PMCID: PMC4359108.
  24. Ceccaldi R, Liu JC, Amunugama R, Hajdu I, Primack B, Petalcorin MI, O'Connor KW, Konstantinopoulos PA, Elledge SJ, Boulton SJ, Yusufzai T, D'Andrea AD. Homologous-recombination-deficient tumours are dependent on Pol?-mediated repair. Nature. 2015 Feb 12; 518(7538):258-62. PMID: 25642963; PMCID: PMC4415602.
  25. Ciccia A, Huang JW, Izhar L, Sowa ME, Harper JW, Elledge SJ. Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response. Proc Natl Acad Sci U S A. 2014 Dec 30; 111(52):18631-6. PMID: 25512513; PMCID: PMC4284564.
  26. Wang R, Persky NS, Yoo B, Ouerfelli O, Smogorzewska A, Elledge SJ, Pavletich NP. DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science. 2014 Nov 28; 346(6213):1127-30. PMID: 25430771; PMCID: PMC4285437.
  27. Seo M, Lee S, Kim JH, Lee WH, Hu G, Elledge SJ, Suk K. RNAi-based functional selection identifies novel cell migration determinants dependent on PI3K and AKT pathways. Nat Commun. 2014 Oct 28; 5:5217. PMID: 25347953.
    View in: PubMed
  28. Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, Ng A, Elledge SJ, Brass AL. Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents. Cell Rep. 2014 Oct 23; 9(2):752-66. PMID: 25373910; PMCID: PMC4926641.
  29. Finton KA, Friend D, Jaffe J, Gewe M, Holmes MA, Larman HB, Stuart A, Larimore K, Greenberg PD, Elledge SJ, Stamatatos L, Strong RK. Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10. PLoS Pathog. 2014 Sep; 10(9):e1004403. PMID: 25254371; PMCID: PMC4177983.
  30. Kahle KT, Gao G, Zhang J, Latremoliere A, Andrews N, Shang Y, Alessi D, Woolf C, Elledge S, Clapham D. Ronald R. Tasker Young Investigator Award 165 Promoting Endogenous GABAergic Analgesia via Kinase Modulation of Neuronal Ion Plasticity. Neurosurgery. 2014 Aug; 61 Suppl 1:214. PMID: 25032616.
    View in: PubMed
  31. Tan X, Elledge SJ. When noise makes music: HIV reactivation with transcriptional noise enhancers. Genome Med. 2014; 6(7):55. PMID: 25276233; PMCID: PMC4179226.
  32. Li J, Zhu S, Kozono D, Ng K, Futalan D, Shen Y, Akers JC, Steed T, Kushwaha D, Schlabach M, Carter BS, Kwon CH, Furnari F, Cavenee W, Elledge S, Chen CC. Genome-wide shRNA screen revealed integrated mitogenic signaling between dopamine receptor D2 (DRD2) and epidermal growth factor receptor (EGFR) in glioblastoma. Oncotarget. 2014 Feb 28; 5(4):882-93. PMID: 24658464; PMCID: PMC4011590.
  33. Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3781-6. PMID: 24556985; PMCID: PMC3956149.
  34. Olive AJ, Haff MG, Emanuele MJ, Sack LM, Barker JR, Elledge SJ, Starnbach MN. Chlamydia trachomatis-induced alterations in the host cell proteome are required for intracellular growth. Cell Host Microbe. 2014 Jan 15; 15(1):113-24. PMID: 24439903; PMCID: PMC3932326.
  35. Larman HB, Liang AC, Elledge SJ, Zhu J. Discovery of protein interactions using parallel analysis of translated ORFs (PLATO). Nat Protoc. 2014 Jan; 9(1):90-103. PMID: 24336473; PMCID: PMC4129458.
  36. Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA. Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells. Stem Cells. 2013 Dec; 31(12):2833-41. PMID: 23765749; PMCID: PMC4617635.
  37. Lin TY, Chin CR, Everitt AR, Clare S, Perreira JM, Savidis G, Aker AM, John SP, Sarlah D, Carreira EM, Elledge SJ, Kellam P, Brass AL. Amphotericin B increases influenza A virus infection by preventing IFITM3-mediated restriction. Cell Rep. 2013 Nov 27; 5(4):895-908. PMID: 24268777; PMCID: PMC3898084.
  38. Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013 Nov 07; 155(4):948-62. PMID: 24183448; PMCID: PMC3891052.
  39. Finton KA, Larimore K, Larman HB, Friend D, Correnti C, Rupert PB, Elledge SJ, Greenberg PD, Strong RK. Autoreactivity and exceptional CDR plasticity (but not unusual polyspecificity) hinder elicitation of the anti-HIV antibody 4E10. PLoS Pathog. 2013; 9(9):e1003639. PMID: 24086134; PMCID: PMC3784475.
  40. Altindis E, Alpar MA, Aksay E, Beckwith J, Bökel C, Curl RF, Darnell RB, Elledge SJ, Erman B, Frahm J, Goff SP, Greengard P, Hoffmann R, Ilhan B, Kaslin J, Lipkin SM, Poulopoulou C, Raz E, Rubin MA, Salturk M, Schrock RR, Trautmann A, Unutmaz D, Weinstein H, Kizil C. Turkey must end violent response to protests. Science. 2013 Jul 19; 341(6143):236. PMID: 23869001.
    View in: PubMed
  41. John SP, Chin CR, Perreira JM, Feeley EM, Aker AM, Savidis G, Smith SE, Elia AE, Everitt AR, Vora M, Pertel T, Elledge SJ, Kellam P, Brass AL. The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. J Virol. 2013 Jul; 87(14):7837-52. PMID: 23658454; PMCID: PMC3700195.
  42. Pavlova NN, Pallasch C, Elia AE, Braun CJ, Westbrook TF, Hemann M, Elledge SJ. A role for PVRL4-driven cell-cell interactions in tumorigenesis. Elife. 2013 Apr 30; 2:e00358. PMID: 23682311; PMCID: PMC3641523.
  43. Zhu J, Larman HB, Gao G, Somwar R, Zhang Z, Laserson U, Ciccia A, Pavlova N, Church G, Zhang W, Kesari S, Elledge SJ. Protein interaction discovery using parallel analysis of translated ORFs (PLATO). Nat Biotechnol. 2013 Apr; 31(4):331-4. PMID: 23503679; PMCID: PMC4110636.
  44. Larman HB, Laserson U, Querol L, Verhaeghen K, Solimini NL, Xu GJ, Klarenbeek PL, Church GM, Hafler DA, Plenge RM, Nigrovic PA, De Jager PL, Weets I, Martens GA, O'Connor KC, Elledge SJ. PhIP-Seq characterization of autoantibodies from patients with multiple sclerosis, type 1 diabetes and rheumatoid arthritis. J Autoimmun. 2013 Jun; 43:1-9. PMID: 23497938; PMCID: PMC3677742.
  45. Larman HB, Salajegheh M, Nazareno R, Lam T, Sauld J, Steen H, Kong SW, Pinkus JL, Amato AA, Elledge SJ, Greenberg SA. Cytosolic 5'-nucleotidase 1A autoimmunity in sporadic inclusion body myositis. Ann Neurol. 2013 Mar; 73(3):408-18. PMID: 23596012.
    View in: PubMed
  46. Liu Q, Xu C, Kirubakaran S, Zhang X, Hur W, Liu Y, Kwiatkowski NP, Wang J, Westover KD, Gao P, Ercan D, Niepel M, Thoreen CC, Kang SA, Patricelli MP, Wang Y, Tupper T, Altabef A, Kawamura H, Held KD, Chou DM, Elledge SJ, Janne PA, Wong KK, Sabatini DM, Gray NS. Characterization of Torin2, an ATP-competitive inhibitor of mTOR, ATM, and ATR. Cancer Res. 2013 Apr 15; 73(8):2574-86. PMID: 23436801; PMCID: PMC3760004.
  47. Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ. STOP gene Phactr4 is a tumor suppressor. Proc Natl Acad Sci U S A. 2013 Jan 29; 110(5):E407-14. PMID: 23319639; PMCID: PMC3562831.
  48. Wang CI, Alekseyenko AA, LeRoy G, Elia AE, Gorchakov AA, Britton LM, Elledge SJ, Kharchenko PV, Garcia BA, Kuroda MI. Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Nat Struct Mol Biol. 2013 Feb; 20(2):202-9. PMID: 23295261; PMCID: PMC3674866.
  49. Tan X, Hu L, Luquette LJ, Gao G, Liu Y, Qu H, Xi R, Lu ZJ, Park PJ, Elledge SJ. Systematic identification of synergistic drug pairs targeting HIV. Nat Biotechnol. 2012 Nov; 30(11):1125-30. PMID: 23064238; PMCID: PMC3494743.
  50. Larman HB, Xu GJ, Pavlova NN, Elledge SJ. Construction of a rationally designed antibody platform for sequencing-assisted selection. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):18523-8. PMID: 23064642; PMCID: PMC3494914.
  51. Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL. Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep. 2012 Oct 25; 2(4):807-16. PMID: 23041316; PMCID: PMC3523124.
  52. Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell. 2012 Aug 10; 47(3):396-409. PMID: 22704558; PMCID: PMC3613862.
  53. Solimini NL, Xu Q, Mermel CH, Liang AC, Schlabach MR, Luo J, Burrows AE, Anselmo AN, Bredemeyer AL, Li MZ, Beroukhim R, Meyerson M, Elledge SJ. Recurrent hemizygous deletions in cancers may optimize proliferative potential. Science. 2012 Jul 06; 337(6090):104-9. PMID: 22628553; PMCID: PMC4027969.
  54. Elia AE, Elledge SJ. BRCA1 as tumor suppressor: lord without its RING? Breast Cancer Res. 2012 Apr 10; 14(2):306. PMID: 22494569; PMCID: PMC3446363.
  55. Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, Bentires-Alj M. Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop. Nat Med. 2012 Mar 04; 18(4):529-37. PMID: 22388088.
    View in: PubMed
  56. Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol. 2012 Feb 19; 14(3):318-28. PMID: 22344029; PMCID: PMC3290715.
  57. Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJ. Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):869-74. PMID: 22219365; PMCID: PMC3271875.
  58. Li MZ, Elledge SJ. SLIC: a method for sequence- and ligation-independent cloning. Methods Mol Biol. 2012; 852:51-9. PMID: 22328425.
    View in: PubMed
  59. Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science. 2012 Jan 20; 335(6066):348-53. PMID: 22157079; PMCID: PMC4059214.
  60. Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL. IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog. 2011 Oct; 7(10):e1002337. PMID: 22046135; PMCID: PMC3203188.
  61. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Global identification of modular cullin-RING ligase substrates. Cell. 2011 Oct 14; 147(2):459-74. PMID: 21963094; PMCID: PMC3226719.
  62. Hajdu I, Ciccia A, Lewis SM, Elledge SJ. Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13130-4. PMID: 21788515; PMCID: PMC3156169.
  63. Joo W, Xu G, Persky NS, Smogorzewska A, Rudge DG, Buzovetsky O, Elledge SJ, Pavletich NP. Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway. Science. 2011 Jul 15; 333(6040):312-6. PMID: 21764741; PMCID: PMC3310437.
  64. Cotta-Ramusino C, McDonald ER, Hurov K, Sowa ME, Harper JW, Elledge SJ. A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science. 2011 Jun 10; 332(6035):1313-7. PMID: 21659603; PMCID: PMC4357496.
  65. Emanuele MJ, Ciccia A, Elia AE, Elledge SJ. Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Proc Natl Acad Sci U S A. 2011 Jun 14; 108(24):9845-50. PMID: 21628590; PMCID: PMC3116415.
  66. Larman HB, Zhao Z, Laserson U, Li MZ, Ciccia A, Gakidis MA, Church GM, Kesari S, Leproust EM, Solimini NL, Elledge SJ. Autoantigen discovery with a synthetic human peptidome. Nat Biotechnol. 2011 May 22; 29(6):535-41. PMID: 21602805; PMCID: PMC4169279.
  67. Sun T, Aceto N, Meerbrey KL, Kessler JD, Zhou C, Migliaccio I, Nguyen DX, Pavlova NN, Botero M, Huang J, Bernardi RJ, Schmitt E, Hu G, Li MZ, Dephoure N, Gygi SP, Rao M, Creighton CJ, Hilsenbeck SG, Shaw CA, Muzny D, Gibbs RA, Wheeler DA, Osborne CK, Schiff R, Bentires-Alj M, Elledge SJ, Westbrook TF. Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase. Cell. 2011 Mar 04; 144(5):703-18. PMID: 21376233.
    View in: PubMed
  68. Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW. Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Mol Cell. 2011 Mar 18; 41(6):733-46. PMID: 21353615; PMCID: PMC3130540.
  69. Meerbrey KL, Hu G, Kessler JD, Roarty K, Li MZ, Fang JE, Herschkowitz JI, Burrows AE, Ciccia A, Sun T, Schmitt EM, Bernardi RJ, Fu X, Bland CS, Cooper TA, Schiff R, Rosen JM, Westbrook TF, Elledge SJ. The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo. Proc Natl Acad Sci U S A. 2011 Mar 01; 108(9):3665-70. PMID: 21307310; PMCID: PMC3048138.
  70. Huang IC, Bailey CC, Weyer JL, Radoshitzky SR, Becker MM, Chiang JJ, Brass AL, Ahmed AA, Chi X, Dong L, Longobardi LE, Boltz D, Kuhn JH, Elledge SJ, Bavari S, Denison MR, Choe H, Farzan M. Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus. PLoS Pathog. 2011 Jan 06; 7(1):e1001258. PMID: 21253575; PMCID: PMC3017121.
  71. Kapitzky L, Beltrao P, Berens TJ, Gassner N, Zhou C, Wüster A, Wu J, Babu MM, Elledge SJ, Toczyski D, Lokey RS, Krogan NJ. Cross-species chemogenomic profiling reveals evolutionarily conserved drug mode of action. Mol Syst Biol. 2010 Dec 21; 6:451. PMID: 21179023; PMCID: PMC3018166.
  72. O'Connell BC, Adamson B, Lydeard JR, Sowa ME, Ciccia A, Bredemeyer AL, Schlabach M, Gygi SP, Elledge SJ, Harper JW. A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability. Mol Cell. 2010 Nov 24; 40(4):645-57. PMID: 21055985; PMCID: PMC3006237.
  73. Ciccia A, Elledge SJ. The DNA damage response: making it safe to play with knives. Mol Cell. 2010 Oct 22; 40(2):179-204. PMID: 20965415; PMCID: PMC2988877.
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  267. Pearlman JA, Powaser PA, Elledge SJ, Caskey CT. Troponin T is capable of binding dystrophin via a leucine zipper. FEBS Lett. 1994 Nov 07; 354(2):183-6. PMID: 7957921.
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  268. Durfee T, Mancini MA, Jones D, Elledge SJ, Lee WH. The amino-terminal region of the retinoblastoma gene product binds a novel nuclear matrix protein that co-localizes to centers for RNA processing. J Cell Biol. 1994 Nov; 127(3):609-22. PMID: 7525595; PMCID: PMC2120229.
  269. Allen JB, Zhou Z, Siede W, Friedberg EC, Elledge SJ. The SAD1/RAD53 protein kinase controls multiple checkpoints and DNA damage-induced transcription in yeast. Genes Dev. 1994 Oct 15; 8(20):2401-15. PMID: 7958905.
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  270. Allen JB, Elledge SJ. A family of vectors that facilitate transposon and insertional mutagenesis of cloned genes in yeast. Yeast. 1994 Oct; 10(10):1267-72. PMID: 7900415.
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  271. Flores-Rozas H, Kelman Z, Dean FB, Pan ZQ, Harper JW, Elledge SJ, O'Donnell M, Hurwitz J. Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme. Proc Natl Acad Sci U S A. 1994 Aug 30; 91(18):8655-9. PMID: 7915843; PMCID: PMC44665.
  272. Inouye C, Remondelli P, Karin M, Elledge S. Isolation of a cDNA encoding a metal response element binding protein using a novel expression cloning procedure: the one hybrid system. DNA Cell Biol. 1994 Jul; 13(7):731-42. PMID: 7772254.
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  273. Li L, Elledge SJ, Peterson CA, Bales ES, Legerski RJ. Specific association between the human DNA repair proteins XPA and ERCC1. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5012-6. PMID: 8197174; PMCID: PMC43920.
  274. Dulic V, Kaufmann WK, Wilson SJ, Tlsty TD, Lees E, Harper JW, Elledge SJ, Reed SI. p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest. Cell. 1994 Mar 25; 76(6):1013-23. PMID: 8137420.
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  275. Helps NR, Street AJ, Elledge SJ, Cohen PT. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. FEBS Lett. 1994 Feb 28; 340(1-2):93-8. PMID: 8119416.
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  276. Zhou Z, Elledge SJ. DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell. 1993 Dec 17; 75(6):1119-27. PMID: 8261511.
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  277. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993 Nov 19; 75(4):805-16. PMID: 8242751.
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  278. Zhang XF, Settleman J, Kyriakis JM, Takeuchi-Suzuki E, Elledge SJ, Marshall MS, Bruder JT, Rapp UR, Avruch J. Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1. Nature. 1993 Jul 22; 364(6435):308-13. PMID: 8332187.
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  279. Elledge SJ, Zhou Z, Allen JB, Navas TA. DNA damage and cell cycle regulation of ribonucleotide reductase. Bioessays. 1993 May; 15(5):333-9. PMID: 8343143.
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  280. Leach FS, Elledge SJ, Sherr CJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B. Amplification of cyclin genes in colorectal carcinomas. Cancer Res. 1993 May 01; 53(9):1986-9. PMID: 8481900.
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  281. Durfee T, Becherer K, Chen PL, Yeh SH, Yang Y, Kilburn AE, Lee WH, Elledge SJ. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev. 1993 Apr; 7(4):555-69. PMID: 8384581.
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  282. Staudinger J, Perry M, Elledge SJ, Olson EN. Interactions among vertebrate helix-loop-helix proteins in yeast using the two-hybrid system. J Biol Chem. 1993 Mar 05; 268(7):4608-11. PMID: 8383120.
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  283. Ramer SW, Elledge SJ, Davis RW. Dominant genetics using a yeast genomic library under the control of a strong inducible promoter. Proc Natl Acad Sci U S A. 1992 Dec 01; 89(23):11589-93. PMID: 1454852; PMCID: PMC50598.
  284. Koff A, Giordano A, Desai D, Yamashita K, Harper JW, Elledge S, Nishimoto T, Morgan DO, Franza BR, Roberts JM. Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle. Science. 1992 Sep 18; 257(5077):1689-94. PMID: 1388288.
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  285. Zhou Z, Elledge SJ. Isolation of crt mutants constitutive for transcription of the DNA damage inducible gene RNR3 in Saccharomyces cerevisiae. Genetics. 1992 Aug; 131(4):851-66. PMID: 1516817; PMCID: PMC1205097.
  286. Elledge SJ, Richman R, Hall FL, Williams RT, Lodgson N, Harper JW. CDK2 encodes a 33-kDa cyclin A-associated protein kinase and is expressed before CDC2 in the cell cycle. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2907-11. PMID: 1372993; PMCID: PMC48772.
  287. Elledge SJ, Zhou Z, Allen JB. Ribonucleotide reductase: regulation, regulation, regulation. Trends Biochem Sci. 1992 Mar; 17(3):119-23. PMID: 1412696.
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  288. Bellen HJ, D'Evelyn D, Harvey M, Elledge SJ. Isolation of temperature-sensitive diphtheria toxins in yeast and their effects on Drosophila cells. Development. 1992 Mar; 114(3):787-96. PMID: 1618142.
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  289. Elledge SJ, Spottswood MR. A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1. EMBO J. 1991 Sep; 10(9):2653-9. PMID: 1714386; PMCID: PMC452966.
  290. Elledge SJ, Mulligan JT, Ramer SW, Spottswood M, Davis RW. Lambda YES: a multifunctional cDNA expression vector for the isolation of genes by complementation of yeast and Escherichia coli mutations. Proc Natl Acad Sci U S A. 1991 Mar 01; 88(5):1731-5. PMID: 1848010; PMCID: PMC51098.
  291. Elledge SJ, Davis RW. Two genes differentially regulated in the cell cycle and by DNA-damaging agents encode alternative regulatory subunits of ribonucleotide reductase. Genes Dev. 1990 May; 4(5):740-51. PMID: 2199320.
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  292. Jasin M, Elledge SJ, Davis RW, Berg P. Gene targeting at the human CD4 locus by epitope addition. Genes Dev. 1990 Feb; 4(2):157-66. PMID: 1692556.
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  293. Elledge SJ, Davis RW. Identification of the DNA damage-responsive element of RNR2 and evidence that four distinct cellular factors bind it. Mol Cell Biol. 1989 Dec; 9(12):5373-86. PMID: 2685561; PMCID: PMC363705.
  294. Elledge SJ, Davis RW. DNA damage induction of ribonucleotide reductase. Mol Cell Biol. 1989 Nov; 9(11):4932-40. PMID: 2513480; PMCID: PMC363644.
  295. Elledge SJ, Sugiono P, Guarente L, Davis RW. Genetic selection for genes encoding sequence-specific DNA-binding proteins. Proc Natl Acad Sci U S A. 1989 May; 86(10):3689-93. PMID: 2657725; PMCID: PMC287205.
  296. Elledge SJ, Davis RW. Position and density effects on repression by stationary and mobile DNA-binding proteins. Genes Dev. 1989 Feb; 3(2):185-97. PMID: 2523839.
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  297. Elledge SJ, Davis RW. A family of versatile centromeric vectors designed for use in the sectoring-shuffle mutagenesis assay in Saccharomyces cerevisiae. Gene. 1988 Oct 30; 70(2):303-12. PMID: 3063604.
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  298. Elledge SJ, Davis RW. Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Mol Cell Biol. 1987 Aug; 7(8):2783-93. PMID: 3313004; PMCID: PMC367895.
  299. Snyder M, Elledge S, Sweetser D, Young RA, Davis RW. Lambda gt 11: gene isolation with antibody probes and other applications. Methods Enzymol. 1987; 154:107-28. PMID: 2448583.
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  300. Snyder M, Elledge S, Davis RW. Rapid mapping of antigenic coding regions and constructing insertion mutations in yeast genes by mini-Tn10 "transplason" mutagenesis. Proc Natl Acad Sci U S A. 1986 Feb; 83(3):730-4. PMID: 3003747; PMCID: PMC322938.
  301. Perry KL, Elledge SJ, Mitchell BB, Marsh L, Walker GC. umuDC and mucAB operons whose products are required for UV light- and chemical-induced mutagenesis: UmuD, MucA, and LexA proteins share homology. Proc Natl Acad Sci U S A. 1985 Jul; 82(13):4331-5. PMID: 2989816; PMCID: PMC390407.
  302. Elledge SJ, Walker GC. Phasmid vectors for identification of genes by complementation of Escherichia coli mutants. J Bacteriol. 1985 May; 162(2):777-83. PMID: 2985547; PMCID: PMC218919.
  303. Winans SC, Elledge SJ, Krueger JH, Walker GC. Site-directed insertion and deletion mutagenesis with cloned fragments in Escherichia coli. J Bacteriol. 1985 Mar; 161(3):1219-21. PMID: 2982787; PMCID: PMC215030.
  304. Elledge SJ, Walker GC. The muc genes of pKM101 are induced by DNA damage. J Bacteriol. 1983 Sep; 155(3):1306-15. PMID: 6350267; PMCID: PMC217829.
  305. Krueger JH, Elledge SJ, Walker GC. Isolation and characterization of Tn5 insertion mutations in the lexA gene of Escherichia coli. J Bacteriol. 1983 Mar; 153(3):1368-78. PMID: 6298183; PMCID: PMC221787.
  306. Elledge SJ, Walker GC. Proteins required for ultraviolet light and chemical mutagenesis. Identification of the products of the umuC locus of Escherichia coli. J Mol Biol. 1983 Feb 25; 164(2):175-92. PMID: 6302271.
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  307. Walker GC, Elledge SJ, Perry KL, Bagg A, Kenyon CJ. Regulation and function of cellular gene products involved in UV and chemical mutagenesis in E. coli. Basic Life Sci. 1983; 23:181-202. PMID: 6340657.
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  308. Walker GC, Elledge SJ, Kenyon CJ, Krueger JH, Perry KL. Mutagenesis and other responses induced by DNA damage in Escherichia coli. Biochimie. 1982 Aug-Sep; 64(8-9):607-10. PMID: 6291635.
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  309. Walker GC, Kenyon CJ, Bagg A, Elledge SJ, Perry KL, Shanabruch WG. Regulation and functions of Escherichia coli genes induced by DNA damage. Basic Life Sci. 1982; 20:43-63. PMID: 6287997.
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