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Eric Paul Wehrenberg-Klee, M.D.

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Mentoring
Available: 01/01/20, Expires: 01/01/22

Cryoablation may promote immune system recognition of tumors by releasing tumor antigen and inflammatory intracellular contents. We have shown that cryoablation of one tumor significantly increases the complete response rate to checkpoint inhibitor therapy (anti-PD-1, anti-CTLA-4). We continue to work on improving understanding of mechanisms or response and resistance, and how this technique can be further improved to increase its value in the treatment of cancer.

We are interested in a medical student willing to commit to a minimum of 6 months to complete an mentored subproject focused on the use of additional intra tumoral dendritic cell activators to further improve response.


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Liu J, Sun X, Ganguli S, Wehrenberg-Klee EP, Bhan I, Zhao Y, Zhao L, Meng K, Sun R, Yu H, Sun G. Partial splenic embolization is superior to intravenous somatostatin for decreasing portal pressure in cirrhotic patients: a dynamic self-controlled cohort study. Scand J Gastroenterol. 2020 Nov; 55(11):1341-1346. PMID: 33076704.
    Citations:    Fields:    
  2. Liu J, Wehrenberg-Klee EP, Bethea ED, Uppot RN, Yamada K, Ganguli S. Transjugular Intrahepatic Portosystemic Shunt Placement for Portal Hypertension: Meta-Analysis of Safety and Efficacy of 8?mm vs. 10?mm Stents. Gastroenterol Res Pract. 2020; 2020:9149065. PMID: 33123192.
    Citations:    
  3. LaSalle T, Austin EE, Rigney G, Wehrenberg-Klee E, Nesti S, Larimer B, Mahmood U. Granzyme B PET imaging of immune-mediated tumor killing as a tool for understanding immunotherapy response. J Immunother Cancer. 2020 May; 8(1). PMID: 32461343.
    Citations: 1     Fields:    
  4. Li MD, Chu KF, DePietro A, Wu V, Wehrenberg-Klee E, Zurkiya O, Liu RW, Ganguli S. Same-Day Yttrium-90 Radioembolization: Feasibility with Resin Microspheres. J Vasc Interv Radiol. 2019 03; 30(3):314-319. PMID: 30819470.
    Citations:    Fields:    Translation:Humans
  5. Wehrenberg-Klee E, Gandhi RT, Ganguli S. Patient Selection and Clinical Outcomes of Y90 in Hepatocellular Carcinoma. Tech Vasc Interv Radiol. 2019 Jun; 22(2):70-73. PMID: 31079713.
    Citations: 2     Fields:    Translation:Humans
  6. Larimer BM, Bloch E, Nesti S, Austin EE, Wehrenberg-Klee E, Boland G, Mahmood U. The Effectiveness of Checkpoint Inhibitor Combinations and Administration Timing Can Be Measured by Granzyme B PET Imaging. Clin Cancer Res. 2019 02 15; 25(4):1196-1205. PMID: 30327313.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  7. Shao H, McCarthy C, Wehrenberg-Klee E, Thabet A, Uppot R, Dawson S, Arellano RS. CT-Guided Percutaneous Needle Biopsy of Retroperitoneal and Pelvic Lymphadenopathy: Assessment of Technique, Diagnostic Yield, and Clinical Value. J Vasc Interv Radiol. 2018 10; 29(10):1429-1436. PMID: 30174157.
    Citations: 1     Fields:    Translation:Humans
  8. Wehrenberg-Klee E, Goyal L, Dugan M, Zhu AX, Ganguli S. Y-90 Radioembolization Combined with a PD-1 Inhibitor for Advanced Hepatocellular Carcinoma. Cardiovasc Intervent Radiol. 2018 Nov; 41(11):1799-1802. PMID: 29845347.
    Citations: 4     Fields:    Translation:Humans
  9. Larimer BM, Phelan N, Wehrenberg-Klee E, Mahmood U. Phage Display Selection, In Vitro Characterization, and Correlative PET Imaging of a Novel HER3 Peptide. Mol Imaging Biol. 2018 04; 20(2):300-308. PMID: 28733706.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Larimer BM, Wehrenberg-Klee E, Dubois F, Mehta A, Kalomeris T, Flaherty K, Boland G, Mahmood U. Granzyme B PET Imaging as a Predictive Biomarker of Immunotherapy Response. Cancer Res. 2017 05 01; 77(9):2318-2327. PMID: 28461564.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  11. Larimer BM, Wehrenberg-Klee E, Caraballo A, Mahmood U. Quantitative CD3 PET Imaging Predicts Tumor Growth Response to Anti-CTLA-4 Therapy. J Nucl Med. 2016 Oct; 57(10):1607-1611. PMID: 27230929.
    Citations: 25     Fields:    Translation:AnimalsCells
  12. Wehrenberg-Klee E, Turker NS, Heidari P, Larimer B, Juric D, Baselga J, Scaltriti M, Mahmood U. Differential Receptor Tyrosine Kinase PET Imaging for Therapeutic Guidance. J Nucl Med. 2016 09; 57(9):1413-9. PMID: 27081168.
    Citations: 7     Fields:    Translation:HumansCells
  13. Wehrenberg-Klee E, Redjal N, Leece A, Turker NS, Heidari P, Shah K, Mahmood U. PET imaging of glioblastoma multiforme EGFR expression for therapeutic decision guidance. Am J Nucl Med Mol Imaging. 2015; 5(4):379-89. PMID: 26269775.
    Citations: 5     
  14. Heidari P, Wehrenberg-Klee E, Habibollahi P, Yokell D, Kulke M, Mahmood U. Free somatostatin receptor fraction predicts the antiproliferative effect of octreotide in a neuroendocrine tumor model: implications for dose optimization. Cancer Res. 2013 Dec 01; 73(23):6865-73. PMID: 24080280.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  15. Truesdale CM, Soulen MC, Clark TW, Mondschein JI, Wehrenberg-Klee E, Malkowicz SB, Wein AJ, Guzzo TJ, Stavropoulos SW. Percutaneous computed tomography-guided renal mass radiofrequency ablation versus cryoablation: doses of sedation medication used. J Vasc Interv Radiol. 2013 Mar; 24(3):347-50. PMID: 23433410.
    Citations: 4     Fields:    Translation:Humans
  16. Wehrenberg-Klee E, Stavropoulos SW. Inferior vena cava filters for primary prophylaxis: when are they indicated? Semin Intervent Radiol. 2012 Mar; 29(1):29-35. PMID: 23450194.
    Citations: 5     
  17. Wehrenberg-Klee E, Clark TW, Malkowicz SB, Soulen MC, Wein AJ, Mondschein JI, Van Arsdalen K, Guzzo TJ, Stavropoulos SW. Impact on renal function of percutaneous thermal ablation of renal masses in patients with preexisting chronic kidney disease. J Vasc Interv Radiol. 2012 Jan; 23(1):41-5. PMID: 22019179.
    Citations: 6     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.