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profileGriffin M Weber, M.D., Ph.D.

TitleResearch Associate in Biomedical Informatics
InstitutionHarvard Medical School
DepartmentBiomedical Informatics
AddressHarvard Medical School
Countway Lib, Ctr for Biomedical Informatics, Rm 316 a
10 Shattuck St
Boston MA 02115
Phone617/432-6134
vCardDownload vCard (login for email)
Profile Picture
Other Positions
TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
DivisionInterdisciplinary Medicine and Biotechnology


Collapse Biography 
Collapse education and training
Harvard University, BostonSB06/2000Bioengineering
Harvard University, BostonSM06/2004Computer Science
Harvard University, BostonPhD06/2005Computer Science
Harvard University, BostonMD06/2007Medicine
Collapse awards and honors
2003Lee B. Lusted Student Prize
2007Massachusetts Medical Society Medical Technology Award
2010Distinguished Poster Award at AMIA 2010 Annual Symposium
2011Top Podium Presentation at AMIA 2011 Joint Summits on Translational Science

Collapse Overview 
Collapse overview
Griffin Weber, M.D., Ph.D., an Associate Professor of Medicine in the Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS); and the Director of the Biomedical Research Informatics Core (BRIC) at BIDMC.

One of Dr. Weber's research areas is in expertise mining and social network analysis. He invented an open source social networking website for scientists called Profiles RNS (http://profiles.catalyst.harvard.edu). It automatically mines large datasets such as PubMed, NIH ExPORTER, and the U.S. patent database to discover investigators' research areas and scientific networks. It presents these connections using temporal, geospatial, and network visualizations. The software has numerous applications, ranging from finding individual collaborators and mentors to understanding the dynamics of an entire research community. Profiles RNS is now used at dozens of universities across the country.

Dr. Weber is also an investigator on Informatics for Integrating Biology and the Bedside (i2b2), an NIH National Center for Biomedical Computing, for which he helped developed a web-based open source platform that enables a variety of functions including queries of large clinical repositories for hypothesis testing and identification of patients for clinical trials (http://i2b2.org). He also created the original prototype software for the Shared Health Research Information Network (SHRINE), which is a federated query tool that connects i2b2 databases across multiple institutions. More than 100 institutions worldwide use i2b2 and SHRINE to support clinical research.

Dr. Weber received his M.D. and Ph.D. in computer science from Harvard University in 2007. While still a student, he became the first Chief Technology Officer of Harvard Medical School and built an educational web portal that provides interactive online content to over 500 courses. His past research projects also include analyzing DNA microarrays, modeling the growth of breast cancer tumors, and creating algorithms for predicting life expectancy.


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
CDRN130604608     (MANDL, KENNETH)Oct 1, 2015 - Sep 1, 2018
PCORI
Collaborative Infrastructure for a Learning Healthcare System
Role: Co-Investigator

U01CA198934     (WEBER, GRIFFIN M)Jun 1, 2015 - May 31, 2018
NIH/NCI
Visualizing healthcare system dynamics in biomedical Big Data
Role: Principal Investigator

U01GM112623     (WEBER, GRIFFIN M)Jan 15, 2015 - Dec 31, 2018
NIH/NIGMS
Modeling scientific workforce dynamics using social network analysis
Role: Principal Investigator

U54HG007963     (KOHANE, ISAAC S.)Sep 29, 2014 - Aug 31, 2018
NIH/NHGRI
Patient-Centered Information Commons
Role: Co-Investigator

1360042     (WEBER, GRIFFIN M)May 1, 2014 - Apr 30, 2017
NSF/SciSIP
Identifying cross-disciplinary pathways to translational science
Role: Principal Investigator

Collapse Featured Content 
Collapse Websites
Collapse Media Links
Collapse Presentations
Collapse Twitter
Collapse Videos

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Warner ET, Carapinha R, Weber GM, Hill EV, Reede JY. Gender Differences in Receipt of National Institutes of Health R01 Grants Among Junior Faculty at an Academic Medical Center: The Role of Connectivity, Rank, and Research Productivity. J Womens Health (Larchmt). 2017 Aug 03. PMID: 28771391.
    View in: PubMed
  2. Mantia C, Uhlmann EJ, Puligandla M, Weber GM, Neuberg D, Zwicker JI. Predicting the higher rate of intracranial hemorrhage in glioma patients receiving therapeutic enoxaparin. Blood. 2017 Jun 22; 129(25):3379-3385. PMID: 28468796.
    View in: PubMed
  3. Hauser TH, Salastekar N, Schaefer EJ, Desai T, Goldfine HL, Fowler KM, Weber GM, Welty F, Clouse M, Shoelson SE, Goldfine AB. Effect of Targeting Inflammation With Salsalate: The TINSAL-CVD Randomized Clinical Trial on Progression of Coronary Plaque in Overweight and Obese Patients Using Statins. JAMA Cardiol. 2016 Jul 01; 1(4):413-23. PMID: 27438317.
    View in: PubMed
  4. Warner ET, Carapinha R, Weber GM, Hill EV, Reede JY. Faculty Promotion and Attrition: The Importance of Coauthor Network Reach at an Academic Medical Center. J Gen Intern Med. 2016 Jan; 31(1):60-7. PMID: 26173540; PMCID: PMC4700018 [Available on 01/01/17].
  5. Warner ET, Carapinha R, Weber GM, Hill EV, Reede JY. Considering context in academic medicine: differences in demographic and professional characteristics and in research productivity and advancement metrics across seven clinical departments. Acad Med. 2015 Aug; 90(8):1077-83. PMID: 25853687.
    View in: PubMed
  6. Donato J, Campigotto F, Uhlmann EJ, Coletti E, Neuberg D, Weber GM, Zwicker JI. Intracranial hemorrhage in patients with brain metastases treated with therapeutic enoxaparin: a matched cohort study. Blood. 2015 Jul 23; 126(4):494-9. PMID: 25987658; PMCID: PMC4548746.
  7. Weber GM. Federated queries of clinical data repositories: Scaling to a national network. J Biomed Inform. 2015 Jun; 55:231-6. PMID: 25957825; PMCID: PMC4464929.
  8. Weber GM, Mandl KD, Kohane IS. Finding the missing link for big biomedical data. JAMA. 2014 Jun 25; 311(24):2479-80. PMID: 24854141.
    View in: PubMed
  9. Mandl KD, Kohane IS, McFadden D, Weber GM, Natter M, Mandel J, Schneeweiss S, Weiler S, Klann JG, Bickel J, Adams WG, Ge Y, Zhou X, Perkins J, Marsolo K, Bernstam E, Showalter J, Quarshie A, Ofili E, Hripcsak G, Murphy SN. Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):615-20. PMID: 24821734; PMCID: PMC4078286.
  10. Klann JG, Buck MD, Brown J, Hadley M, Elmore R, Weber GM, Murphy SN. Query Health: standards-based, cross-platform population health surveillance. J Am Med Inform Assoc. 2014 Jul-Aug; 21(4):650-6. PMID: 24699371; PMCID: PMC4078284.
  11. Kahlon M, Yuan L, Daigre J, Meeks E, Nelson K, Piontkowski C, Reuter K, Sak R, Turner B, Weber GM, Chatterjee A. The use and significance of a research networking system. J Med Internet Res. 2014 Feb 07; 16(2):e46. PMID: 24509520; PMCID: PMC3936277.
  12. Weber GM, Kohane IS. Extracting physician group intelligence from electronic health records to support evidence based medicine. PLoS One. 2013; 8(5):e64933. PMID: 23734227; PMCID: PMC3666978.
  13. Weber GM. Identifying translational science within the triangle of biomedicine. J Transl Med. 2013 May 24; 11:126. PMID: 23705970; PMCID: PMC3666890.
  14. Weber GM. How many patients are "normal"? Only 1.55%. AMIA Jt Summits Transl Sci Proc. 2013; 2013:79. PMID: 24303240.
    View in: PubMed
  15. McMurry AJ, Murphy SN, MacFadden D, Weber G, Simons WW, Orechia J, Bickel J, Wattanasin N, Gilbert C, Trevvett P, Churchill S, Kohane IS. SHRINE: enabling nationally scalable multi-site disease studies. PLoS One. 2013; 8(3):e55811. PMID: 23533569; PMCID: PMC3591385.
  16. Weber GM. Federated queries of clinical data repositories: the sum of the parts does not equal the whole. J Am Med Inform Assoc. 2013 Jun; 20(e1):e155-61. PMID: 23349080; PMCID: PMC3715334.
  17. Natter MD, Quan J, Ortiz DM, Bousvaros A, Ilowite NT, Inman CJ, Marsolo K, McMurry AJ, Sandborg CI, Schanberg LE, Wallace CA, Warren RW, Weber GM, Mandl KD. An i2b2-based, generalizable, open source, self-scaling chronic disease registry. J Am Med Inform Assoc. 2013 Jan 01; 20(1):172-9. PMID: 22733975; PMCID: PMC3555330.
  18. Kohane IS, McMurry A, Weber G, MacFadden D, Rappaport L, Kunkel L, Bickel J, Wattanasin N, Spence S, Murphy S, Churchill S. The co-morbidity burden of children and young adults with autism spectrum disorders. PLoS One. 2012; 7(4):e33224. PMID: 22511918; PMCID: PMC3325235.
  19. Murphy SN, Dubey A, Embi PJ, Harris PA, Richter BG, Turisco F, Weber GM, Tcheng JE, Keogh D. Current state of information technologies for the clinical research enterprise across academic medical centers. Clin Transl Sci. 2012 Jun; 5(3):281-4. PMID: 22686207.
    View in: PubMed
  20. Weber GM, Barnett W, Conlon M, Eichmann D, Kibbe W, Falk-Krzesinski H, Halaas M, Johnson L, Meeks E, Mitchell D, Schleyer T, Stallings S, Warden M, Kahlon M. Direct2Experts: a pilot national network to demonstrate interoperability among research-networking platforms. J Am Med Inform Assoc. 2011 Dec; 18 Suppl 1:i157-60. PMID: 22037890; PMCID: PMC3241163.
  21. Wang KC, Jeanmenne A, Weber GM, Thawait SK, Thawait S, Carrino JA. An online evidence-based decision support system for distinguishing benign from malignant vertebral compression fractures by magnetic resonance imaging feature analysis. J Digit Imaging. 2011 Jun; 24(3):507-15. PMID: 20680384; PMCID: PMC3092053.
  22. Murphy SN, Weber G, Mendis M, Gainer V, Chueh HC, Churchill S, Kohane I. Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). J Am Med Inform Assoc. 2010 Mar-Apr; 17(2):124-30. PMID: 20190053; PMCID: PMC3000779.
  23. Milo R, Jorgensen P, Moran U, Weber G, Springer M. BioNumbers--the database of key numbers in molecular and cell biology. Nucleic Acids Res. 2010 Jan; 38(Database issue):D750-3. PMID: 19854939; PMCID: PMC2808940.
  24. Weber GM, Murphy SN, McMurry AJ, Macfadden D, Nigrin DJ, Churchill S, Kohane IS. The Shared Health Research Information Network (SHRINE): a prototype federated query tool for clinical data repositories. J Am Med Inform Assoc. 2009 Sep-Oct; 16(5):624-30. PMID: 19567788; PMCID: PMC2744712.
  25. Shen LQ, Child A, Weber GM, Folkman J, Aiello LP. Rosiglitazone and delayed onset of proliferative diabetic retinopathy. Arch Ophthalmol. 2008 Jun; 126(6):793-9. PMID: 18541841.
    View in: PubMed
  26. Weber G, Weber G. Pizza Combinatorics Revisited. The College Mathematics Journal. 2006; 37(1):43-4.
  27. Weber G, Ohno-Machado L, Shieber S. Representation in stochastic search for phylogenetic tree reconstruction. J Biomed Inform. 2006 Feb; 39(1):43-50. PMID: 16359929.
    View in: PubMed
  28. Col NF, Weber G, Stiggelbout A, Chuo J, D'Agostino R, Corso P. Short-term menopausal hormone therapy for symptom relief: an updated decision model. Arch Intern Med. 2004 Aug 9-23; 164(15):1634-40. PMID: 15302633.
    View in: PubMed
  29. Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL. Genomic analysis of mouse retinal development. PLoS Biol. 2004 Sep; 2(9):E247. PMID: 15226823; PMCID: PMC439783.
  30. Weber G, Vinterbo S, Ohno-Machado L. Multivariate selection of genetic markers in diagnostic classification. Artif Intell Med. 2004 Jun; 31(2):155-67. PMID: 15219292.
    View in: PubMed
  31. Xu Y, Stange-Thomann N, Weber G, Bo R, Dodge S, David RG, Foley K, Beheshti J, Harris NL, Birren B, Lander ES, Meyerson M. Pathogen discovery from human tissue by sequence-based computational subtraction. Genomics. 2003 Mar; 81(3):329-35. PMID: 12659816.
    View in: PubMed
  32. Michaelson JS, Satija S, Moore R, Weber G, Halpern E, Garland A, Kopans DB. Journal of Women's Imaging. Estimates of Breast Cancer Growth Rate and Sojourn Time from Screening Database Information. 2003; (1):11-19.
  33. Michaelson JS, Satija S, Moore R, Weber G, Halpern E, Garland A, Kopans DB. Journal of Women's Imaging. Estimates of the Sizes at Which Breast Cancers Become Detectable on Mammographic and Clinical Grounds. 2003; (1):3-10.
  34. Michaelson JS, Silverstein M, Wyatt J, Weber G, Moore R, Halpern E, Kopans DB, Hughes K. Predicting the survival of patients with breast carcinoma using tumor size. Cancer. 2002 Aug 15; 95(4):713-23. PMID: 12209713.
    View in: PubMed
  35. Weber G, Shendure J, Tanenbaum DM, Church GM, Meyerson M. Identification of foreign gene sequences by transcript filtering against the human genome. Nat Genet. 2002 Feb; 30(2):141-2. PMID: 11788827.
    View in: PubMed
  36. Col NF, Fortin JM, Weber G. Clearinghouse Number JC020766. Using the Web to Promote Smoking Cessation and Health for College-Aged Women. Educational Resources Information Center. 2002.
  37. Weber G, Vinterbo S, Ohno-Machado L. Building an asynchronous web-based tool for machine learning classification. Proc AMIA Symp. 2002; 869-73. PMID: 12463949; PMCID: PMC2244467.
  38. Ohno-Machado L, Vinterbo S, Weber G. Journal of Intelligent and Fuzzy Systems. Classification of Gene Expression Data Using Fuzzy Logic. 2002; 12(1):19-24.
  39. Michaelson J, Satija S, Moore R, Weber G, Halpern E, Garland A, Puri D, Kopans DB. The pattern of breast cancer screening utilization and its consequences. Cancer. 2002 Jan 01; 94(1):37-43. PMID: 11815958.
    View in: PubMed
  40. Bhattacharjee A, Richards WG, Staunton J, Li C, Monti S, Vasa P, Ladd C, Beheshti J, Bueno R, Gillette M, Loda M, Weber G, Mark EJ, Lander ES, Wong W, Johnson BE, Golub TR, Sugarbaker DJ, Meyerson M. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13790-5. PMID: 11707567; PMCID: PMC61120.
  41. Comander J, Weber GM, Gimbrone MA, García-Cardeña G. Argus--a new database system for Web-based analysis of multiple microarray data sets. Genome Res. 2001 Sep; 11(9):1603-10. PMID: 11544205; PMCID: PMC311087.
  42. Michaelson JS, Satija S, Moore R, Weber G, Halpern E, Garland A, Kopans DB. Journal of Women's Imaging. Observations on Invasive Breast Cancer Diagnosed in a Service Screening and Diagnostic Breast Imaging Program. 2001; 3:99-104.
  43. Weber G, Weber G. Pizza Combinatorics. The College Mathematics Journal. 1995; 26(2):141-3.
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