Harvard Catalyst Profiles

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Gaurav Das Gaiha, M.D.

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Research
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. DP2AI154421 (GAIHA, GAURAV DAS) Sep 1, 2020 - Aug 31, 2025
    NIH
    Exploiting Highly Networked CTL Epitopes to Achieve a Functional HIV Cure
    Role: Principal Investigator
  2. K08AI140960 (GAIHA, GAURAV DAS) Apr 5, 2019 - Mar 31, 2024
    NIH
    Leveraging CTLs targeting highly networked epitopes to suppress the latent HIV-1 reservoir
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Naranbhai V, Garcia-Beltran WF, Chang CC, Berrios Mairena C, Thierauf JC, Kirkpatrick G, Onozato ML, Cheng J, St Denis KJ, Lam EC, Kaseke C, Tano-Menka R, Yang D, Pavlovic M, Yang W, Kui A, Miller TE, Astudillo MG, Cahill JE, Dighe AS, Gregory DJ, Poznansky MC, Gaiha GD, Balazs AB, Iafrate AJ. Comparative Immunogenicity and Effectiveness of mRNA-1273, BNT162b2, and Ad26.COV2.S COVID-19 Vaccines. J Infect Dis. 2022 04 01; 225(7):1141-1150. PMID: 34888672; PMCID: PMC8689763.
    Citations: 22     Fields:    Translation:HumansCells
  2. Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Zhao Z, St Denis KJ, Lam EC, Carrington M, Garcia-Beltran WF, Balazs AB, Walker BD, Iafrate AJ, Gaiha GD. T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals. Cell. 2022 Mar 31; 185(7):1259. PMID: 35364034; PMCID: PMC8969090.
    Citations: 5     Fields:    
  3. Kaneko N, Boucau J, Kuo HH, Perugino C, Mahajan VS, Farmer JR, Liu H, Diefenbach TJ, Piechocka-Trocha A, Lefteri K, Waring MT, Premo KR, Walker BD, Li JZ, Gaiha G, Yu XG, Lichterfeld M, Padera RF, Pillai S. Temporal changes in T cell subsets and expansion of cytotoxic CD4+ T cells in the lungs in severe COVID-19. Clin Immunol. 2022 04; 237:108991. PMID: 35364330; PMCID: PMC8961941.
    Citations: 3     Fields:    Translation:HumansCells
  4. Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Zhao Z, St Denis KJ, Lam EC, Carrington M, Garcia-Beltran WF, Balazs AB, Walker BD, Iafrate AJ, Gaiha GD. T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all individuals. Cell. 2022 03 17; 185(6):1041-1051.e6. PMID: 35202566; PMCID: PMC8810349.
    Citations: 22     Fields:    
  5. Naranbhai V, Nathan A, Kaseke C, Berrios C, Khatri A, Choi S, Getz MA, Tano-Menka R, Ofoman O, Gayton A, Senjobe F, Denis KJS, Lam EC, Garcia-Beltran WF, Balazs AB, Walker BD, Iafrate AJ, Gaiha GD. T cell reactivity to the SARS-CoV-2 Omicron variant is preserved in most but not all prior infected and vaccinated individuals. medRxiv. 2022 Jan 05. PMID: 35018386; PMCID: PMC8750712.
    Citations:    
  6. Naranbhai V, Garcia-Beltran WF, Chang CC, Mairena CB, Thierauf JC, Kirkpatrick G, Onozato ML, Cheng J, St Denis KJ, Lam EC, Kaseke C, Tano-Menka R, Yang D, Pavlovic M, Yang W, Kui A, Miller TE, Astudillo MG, Cahill JE, Dighe AS, Gregory DJ, Poznansky MC, Gaiha GD, Balazs AB, Iafrate AJ. Comparative immunogenicity and effectiveness of mRNA-1273, BNT162b2 and Ad26.COV2.S COVID-19 vaccines. medRxiv. 2021 Oct 13. PMID: 34671780; PMCID: PMC8528089.
    Citations:    
  7. Collins DR, Urbach JM, Racenet ZJ, Arshad U, Power KA, Newman RM, Mylvaganam GH, Ly NL, Lian X, Rull A, Rassadkina Y, Yanez AG, Peluso MJ, Deeks SG, Vidal F, Lichterfeld M, Yu XG, Gaiha GD, Allen TM, Walker BD. Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia. Immunity. 2021 10 12; 54(10):2372-2384.e7. PMID: 34496223; PMCID: PMC8516715.
    Citations: 3     Fields:    Translation:HumansCells
  8. Kaseke C, Park RJ, Singh NK, Koundakjian D, Bashirova A, Garcia Beltran WF, Takou Mbah OC, Ma J, Senjobe F, Urbach JM, Nathan A, Rossin EJ, Tano-Menka R, Khatri A, Piechocka-Trocha A, Waring MT, Birnbaum ME, Baker BM, Carrington M, Walker BD, Gaiha GD. HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV. Cell Rep. 2021 07 13; 36(2):109378. PMID: 34260940; PMCID: PMC8293625.
    Citations: 1     Fields:    Translation:HumansCells
  9. Nathan A, Rossin EJ, Kaseke C, Park RJ, Khatri A, Koundakjian D, Urbach JM, Singh NK, Bashirova A, Tano-Menka R, Senjobe F, Waring MT, Piechocka-Trocha A, Garcia-Beltran WF, Iafrate AJ, Naranbhai V, Carrington M, Walker BD, Gaiha GD. Structure-guided T cell vaccine design for SARS-CoV-2 variants and sarbecoviruses. Cell. 2021 08 19; 184(17):4401-4413.e10. PMID: 34265281; PMCID: PMC8241654.
    Citations: 11     Fields:    Translation:HumansCells
  10. Kaneko N, Boucau J, Kuo HH, Perugino C, Mahajan VS, Farmer JR, Liu H, Diefenbach TJ, Piechocka-Trocha A, Lefteri K, Waring MT, Premo KR, Walker BD, Li JZ, Gaiha G, Yu XG, Lichterfeld M, Padera RF, Pillai S. Expansion of Cytotoxic CD4+ T cells in the lungs in severe COVID-19. medRxiv. 2021 Mar 26. PMID: 33791730; PMCID: PMC8010762.
    Citations:    
  11. Kaseke C, Tano-Menka R, Senjobe F, Gaiha GD. The Emerging Role for CTL Epitope Specificity in HIV Cure Efforts. J Infect Dis. 2021 02 15; 223(12 Suppl 2):32-37. PMID: 33586771; PMCID: PMC7883022.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Garcia-Bates TM, Palma ML, Anderko RR, Hsu DC, Ananworanich J, Korber BT, Gaiha GD, Phanuphak N, Thomas R, Tovanabutra S, Walker BD, Mellors JW, Piazza PA, Kroon E, Riddler SA, Michael NL, Rinaldo CR, Mailliard RB. Dendritic cells focus CTL responses toward highly conserved and topologically important HIV-1 epitopes. EBioMedicine. 2021 Jan; 63:103175. PMID: 33450518.
    Citations: 1     Fields:    Translation:HumansCells
  13. Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, Solomon IH, Kuo HH, Boucau J, Bowman K, Adhikari UD, Winkler ML, Mueller AA, Hsu TY, Desjardins M, Baden LR, Chan BT, Walker BD, Lichterfeld M, Brigl M, Kwon DS, Kanjilal S, Richardson ET, Jonsson AH, Alter G, Barczak AK, Hanage WP, Yu XG, Gaiha GD, Seaman MS, Cernadas M, Li JZ. Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host. N Engl J Med. 2020 12 03; 383(23):2291-2293. PMID: 33176080; PMCID: PMC7673303.
    Citations: 363     Fields:    Translation:HumansCells
  14. Coffey JW, Gaiha GD, Traverso G. Oral Biologic Delivery: Advances Toward Oral Subunit, DNA, and mRNA Vaccines and the Potential for Mass Vaccination During Pandemics. Annu Rev Pharmacol Toxicol. 2021 01 06; 61:517-540. PMID: 32466690.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  15. Collins DR, Gaiha GD, Walker BD. CD8+ T cells in HIV control, cure and prevention. Nat Rev Immunol. 2020 08; 20(8):471-482. PMID: 32051540.
    Citations: 56     Fields:    Translation:HumansCellsPHPublic Health
  16. Gaiha GD, Rossin EJ, Urbach J, Landeros C, Collins DR, Nwonu C, Muzhingi I, Anahtar MN, Waring OM, Piechocka-Trocha A, Waring M, Worrall DP, Ghebremichael MS, Newman RM, Power KA, Allen TM, Chodosh J, Walker BD. Structural topology defines protective CD8+ T cell epitopes in the HIV proteome. Science. 2019 05 03; 364(6439):480-484. PMID: 31048489; PMCID: PMC6855781.
    Citations: 47     Fields:    Translation:HumansCells
  17. Gaiha GD, Walker BD. CD8(+) T Cells and cART: A Dynamic Duo? Immunity. 2016 09 20; 45(3):466-468. PMID: 27653598.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  18. Gaiha GD, McKim KJ, Woods M, Pertel T, Rohrbach J, Barteneva N, Chin CR, Liu D, Soghoian DZ, Cesa K, Wilton S, Waring MT, Chicoine A, Doering T, Wherry EJ, Kaufmann DE, Lichterfeld M, Brass AL, Walker BD. Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis. Immunity. 2014 Dec 18; 41(6):1001-12. PMID: 25526311.
    Citations: 38     Fields:    Translation:HumansCells
  19. Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, Ng A, Elledge SJ, Brass AL. Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents. Cell Rep. 2014 Oct 23; 9(2):752-66. PMID: 25373910.
    Citations: 32     Fields:    Translation:HumansCells
  20. Gaiha GD, Brass AL. Immunology. The fiery side of HIV-induced T cell death. Science. 2014 Jan 24; 343(6169):383-4. PMID: 24458634.
    Citations: 2     Fields:    Translation:HumansCells
  21. Madsen J, Gaiha GD, Palaniyar N, Dong T, Mitchell DA, Clark HW. Surfactant Protein D modulates HIV infection of both T-cells and dendritic cells. PLoS One. 2013; 8(3):e59047. PMID: 23527085.
    Citations: 18     Fields:    Translation:HumansCells
  22. Zhu J, Gaiha GD, John SP, Pertel T, Chin CR, Gao G, Qu H, Walker BD, Elledge SJ, Brass AL. Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep. 2012 Oct 25; 2(4):807-16. PMID: 23041316.
    Citations: 138     Fields:    Translation:HumansCells
  23. Feeley EM, Sims JS, John SP, Chin CR, Pertel T, Chen LM, Gaiha GD, Ryan BJ, Donis RO, Elledge SJ, Brass AL. IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog. 2011 Oct; 7(10):e1002337. PMID: 22046135.
    Citations: 233     Fields:    Translation:HumansAnimalsCells
  24. Singh R, Gaiha G, Werner L, McKim K, Mlisana K, Luban J, Walker BD, Karim SS, Brass AL, Ndung'u T. Association of TRIM22 with the type 1 interferon response and viral control during primary HIV-1 infection. J Virol. 2011 Jan; 85(1):208-16. PMID: 20980524.
    Citations: 36     Fields:    Translation:HumansCells
  25. Gaiha GD, Dong T, Palaniyar N, Mitchell DA, Reid KB, Clark HW. Surfactant protein A binds to HIV and inhibits direct infection of CD4+ cells, but enhances dendritic cell-mediated viral transfer. J Immunol. 2008 Jul 01; 181(1):601-9. PMID: 18566427.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.