Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jeannie T. Lee, M.D.,Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD097665 (LEE, JEANNIE T) Sep 1, 2019 - May 31, 2024
    Spreading of Xist RNA and Polycomb complexes along the inactive X-chromosome.
    Role: Principal Investigator
  2. R01MH118351 (LEE, JEANNIE T) Jul 1, 2019 - Apr 30, 2024
    Investigating a candidate therapeutic for Rett Syndrome
    Role: Principal Investigator
  3. R01DA036895 (LEE, JEANNIE T) Sep 30, 2013 - May 31, 2018
    The RNA-activation platform to treat X-linked disease in a locus-specific manner.
    Role: Principal Investigator
  4. R03MH097478 (LEE, JEANNIE T) May 1, 2012 - Apr 30, 2014
    A high throughput screen for X-reactivation and reprogramming by small molecules
    Role: Principal Investigator
  5. R01GM090278 (LEE, JEANNIE T) Mar 1, 2010 - Jul 31, 2018
    Polycomb complexes targeted to specific loci by long noncoding RNA cofactors.
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Szanto A, Aguilar R, Kesner B, Blum R, Wang D, Cifuentes-Rojas C, Del Rosario BC, Kis-Toth K, Lee JT. A disproportionate impact of G9a methyltransferase deficiency on the X chromosome. Genes Dev. 2021 Jul 01; 35(13-14):1035-1054. PMID: 34168040.
    Citations:    Fields:    
  2. Yin H, Wei C, Lee JT. Revisiting the consequences of deleting the X inactivation center. Proc Natl Acad Sci U S A. 2021 Jun 22; 118(25). PMID: 34161282.
    Citations:    Fields:    
  3. Chu HP, Minajigi A, Chen Y, Morris R, Guh CY, Hsieh YH, Boukhali M, Haas W, Lee JT. iDRiP for the systematic discovery of proteins bound directly to noncoding RNA. Nat Protoc. 2021 07; 16(7):3672-3694. PMID: 34108731.
    Citations:    Fields:    Translation:AnimalsCells
  4. Colognori D, Sunwoo H, Wang D, Wang CY, Lee JT. Xist Repeat A contributes to early recruitment of Polycomb complexes during X-chromosome inactivation. Dev Cell. 2021 05 03; 56(9):1236-1237. PMID: 33945784.
    Citations:    Fields:    Translation:Cells
  5. Kriz AJ, Colognori D, Sunwoo H, Nabet B, Lee JT. Balancing cohesin eviction and retention prevents aberrant chromosomal interactions, Polycomb-mediated repression, and X-inactivation. Mol Cell. 2021 05 06; 81(9):1970-1987.e9. PMID: 33725485.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Rosenberg M, Blum R, Kesner B, Aeby E, Garant JM, Szanto A, Lee JT. Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation. Nat Struct Mol Biol. 2021 01; 28(1):103-117. PMID: 33398172.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Aeby E, Lee HG, Lee YW, Kriz A, Del Rosario BC, Oh HJ, Boukhali M, Haas W, Lee JT. Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover. Nat Cell Biol. 2020 09; 22(9):1116-1129. PMID: 32807903.
    Citations: 3     Fields:    Translation:AnimalsCells
  8. Colognori D, Sunwoo H, Wang D, Wang CY, Lee JT. Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment. Dev Cell. 2020 07 06; 54(1):21-32.e5. PMID: 32531209.
    Citations: 6     Fields:    Translation:AnimalsCells
  9. Schmider AB, Bauer NC, Sunwoo H, Godin MD, Ellis GE, Lee JT, Nigrovic PA, Soberman RJ. Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils. J Biol Chem. 2020 04 24; 295(17):5761-5770. PMID: 32152223.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Yang L, Yildirim E, Kirby JE, Press W, Lee JT. Widespread organ tolerance to Xist loss and X reactivation except under chronic stress in the gut. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):4262-4272. PMID: 32041873.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  11. Hernandez AJ, Zovoilis A, Cifuentes-Rojas C, Han L, Bujisic B, Lee JT. B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2. Proc Natl Acad Sci U S A. 2020 01 07; 117(1):415-425. PMID: 31871160.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  12. Oh HJ, Lee JT. Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on "Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence" by Karner et al. (2019). J Mol Biol. 2020 01 17; 432(2):301-304. PMID: 31892474.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Lewandowski JP, Lee JC, Hwang T, Sunwoo H, Goldstein JM, Groff AF, Chang NP, Mallard W, Williams A, Henao-Meija J, Flavell RA, Lee JT, Gerhardinger C, Wagers AJ, Rinn JL. The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis. Nat Commun. 2019 11 13; 10(1):5137. PMID: 31723143.
    Citations: 15     Fields:    Translation:Animals
  14. Jagtap S, Thanos JM, Fu T, Wang J, Lalonde J, Dial TO, Feiglin A, Chen J, Kohane I, Lee JT, Sheridan SD, Perlis RH. Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett syndrome. Hum Mol Genet. 2019 11 01; 28(21):3625-3636. PMID: 31518399.
    Citations: 1     Fields:    Translation:HumansCells
  15. Wang CY, Brand H, Shaw ND, Talkowski ME, Lee JT. Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans. Genetics. 2019 10; 213(2):685-703. PMID: 31420322.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  16. Wang CY, Colognori D, Sunwoo H, Wang D, Lee JT. PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments. Nat Commun. 2019 07 03; 10(1):2950. PMID: 31270318.
    Citations: 15     Fields:    Translation:AnimalsCells
  17. Colognori D, Sunwoo H, Kriz AJ, Wang CY, Lee JT. Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X. Mol Cell. 2019 04 04; 74(1):101-117.e10. PMID: 30827740.
    Citations: 39     Fields:    Translation:AnimalsCells
  18. Del Rosario BC, Kriz AJ, Del Rosario AM, Anselmo A, Fry CJ, White FM, Sadreyev RI, Lee JT. Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition. Elife. 2019 01 24; 8. PMID: 30676316.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  19. Froberg JE, Pinter SF, Kriz AJ, Jégu T, Lee JT. Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape. Nat Commun. 2018 11 27; 9(1):5004. PMID: 30479398.
    Citations: 15     Fields:    Translation:AnimalsCells
  20. Saltzman AL, Soo MW, Aram R, Lee JT. Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans. Genetics. 2018 11; 210(3):907-923. PMID: 30185429.
    Citations: 2     Fields:    Translation:AnimalsCells
  21. Carrette LLG, Blum R, Ma W, Kelleher RJ, Lee JT. Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):8185-8190. PMID: 30038001.
    Citations: 9     Fields:    Translation:HumansAnimals
  22. Matoba S, Wang H, Jiang L, Lu F, Iwabuchi KA, Wu X, Inoue K, Yang L, Press W, Lee JT, Ogura A, Shen L, Zhang Y. Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development. Cell Stem Cell. 2018 09 06; 23(3):343-354.e5. PMID: 30033120.
    Citations: 25     Fields:    Translation:Animals
  23. Wang CY, Jégu T, Chu HP, Oh HJ, Lee JT. SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X. Cell. 2018 07 12; 174(2):406-421.e25. PMID: 29887375.
    Citations: 37     Fields:    Translation:AnimalsCells
  24. Carrette LLG, Wang CY, Wei C, Press W, Ma W, Kelleher RJ, Lee JT. A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E668-E675. PMID: 29282321.
    Citations: 21     Fields:    Translation:AnimalsCells
  25. Del Rosario BC, Del Rosario AM, Anselmo A, Wang PI, Sadreyev RI, Lee JT. Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation. Dev Cell. 2017 11 06; 43(3):359-371.e6. PMID: 29107559.
    Citations: 6     Fields:    Translation:AnimalsCells
  26. Rosenberg M, Blum R, Kesner B, Maier VK, Szanto A, Lee JT. Denaturing CLIP, dCLIP, Pipeline Identifies Discrete RNA Footprints on Chromatin-Associated Proteins and Reveals that CBX7 Targets 3' UTRs to Regulate mRNA Expression. Cell Syst. 2017 10 25; 5(4):368-385.e15. PMID: 29073373.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  27. Sunwoo H, Colognori D, Froberg JE, Jeon Y, Lee JT. Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1). Proc Natl Acad Sci U S A. 2017 10 03; 114(40):10654-10659. PMID: 28923964.
    Citations: 27     Fields:    Translation:AnimalsCells
  28. Savol AJ, Wang PI, Jeon Y, Colognori D, Yildirim E, Pinter SF, Payer B, Lee JT, Sadreyev RI. Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. PLoS One. 2017; 12(8):e0182568. PMID: 28796844.
    Citations: 3     Fields:    Translation:AnimalsCells
  29. Chu HP, Cifuentes-Rojas C, Kesner B, Aeby E, Lee HG, Wei C, Oh HJ, Boukhali M, Haas W, Lee JT. TERRA RNA Antagonizes ATRX and Protects Telomeres. Cell. 2017 Jun 29; 170(1):86-101.e16. PMID: 28666128.
    Citations: 69     Fields:    Translation:AnimalsCells
  30. Wang CY, Froberg JE, Blum R, Jeon Y, Lee JT. Comment on "Xist recruits the X chromosome to the nuclear lamina to enable chromosome-wide silencing". Science. 2017 06 16; 356(6343). PMID: 28619887.
    Citations: 1     Fields:    Translation:Cells
  31. Jégu T, Aeby E, Lee JT. The X chromosome in space. Nat Rev Genet. 2017 06; 18(6):377-389. PMID: 28479596.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  32. Kundu S, Ji F, Sunwoo H, Jain G, Lee JT, Sadreyev RI, Dekker J, Kingston RE. Polycomb Repressive Complex 1 Generates Discrete Compacted Domains that Change during Differentiation. Mol Cell. 2017 Feb 02; 65(3):432-446.e5. PMID: 28157505.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  33. Zovoilis A, Cifuentes-Rojas C, Chu HP, Hernandez AJ, Lee JT. Destabilization of B2 RNA by EZH2 Activates the Stress Response. Cell. 2016 Dec 15; 167(7):1788-1802.e13. PMID: 27984727.
    Citations: 23     Fields:    Translation:AnimalsCells
  34. Lessing D, Dial TO, Wei C, Payer B, Carrette LL, Kesner B, Szanto A, Jadhav A, Maloney DJ, Simeonov A, Theriault J, Hasaka T, Bedalov A, Bartolomei MS, Lee JT. A high-throughput small molecule screen identifies synergism between DNA methylation and Aurora kinase pathways for X reactivation. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):14366-14371. PMID: 28182563.
    Citations: 11     Fields:    Translation:AnimalsCells
  35. Yang L, Kirby JE, Sunwoo H, Lee JT. Female mice lacking Xist RNA show partial dosage compensation and survive to term. Genes Dev. 2016 08 01; 30(15):1747-60. PMID: 27542829.
    Citations: 22     Fields:    Translation:AnimalsCells
  36. Sun S, Payer B, Namekawa S, An JY, Press W, Catalan-Dibene J, Sunwoo H, Lee JT. Xist imprinting is promoted by the hemizygous (unpaired) state in the male germ line. Proc Natl Acad Sci U S A. 2015 Nov 24; 112(47):14415-22. PMID: 26489649.
    Citations: 9     Fields:    Translation:AnimalsCells
  37. Sunwoo H, Wu JY, Lee JT. The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells. Proc Natl Acad Sci U S A. 2015 Aug 04; 112(31):E4216-25. PMID: 26195790.
    Citations: 34     Fields:    Translation:AnimalsCells
  38. Minajigi A, Froberg J, Wei C, Sunwoo H, Kesner B, Colognori D, Lessing D, Payer B, Boukhali M, Haas W, Lee JT. Chromosomes. A comprehensive Xist interactome reveals cohesin repulsion and an RNA-directed chromosome conformation. Science. 2015 Jul 17; 349(6245). PMID: 26089354.
    Citations: 161     Fields:    Translation:AnimalsCells
  39. Beliveau BJ, Boettiger AN, Avendaño MS, Jungmann R, McCole RB, Joyce EF, Kim-Kiselak C, Bantignies F, Fonseka CY, Erceg J, Hannan MA, Hoang HG, Colognori D, Lee JT, Shih WM, Yin P, Zhuang X, Wu CT. Single-molecule super-resolution imaging of chromosomes and in situ haplotype visualization using Oligopaint FISH probes. Nat Commun. 2015 May 12; 6:7147. PMID: 25962338.
    Citations: 96     Fields:    Translation:AnimalsCells
  40. Pinter SF, Colognori D, Beliveau BJ, Sadreyev RI, Payer B, Yildirim E, Wu CT, Lee JT. Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. Genetics. 2015 Jun; 200(2):537-49. PMID: 25858912.
    Citations: 17     Fields:    Translation:AnimalsCells
  41. O'Connell KE, Mikkola AM, Stepanek AM, Vernet A, Hall CD, Sun CC, Yildirim E, Staropoli JF, Lee JT, Brown DE. Practical murine hematopathology: a comparative review and implications for research. Comp Med. 2015 Apr; 65(2):96-113. PMID: 25926395.
    Citations: 41     Fields:    Translation:HumansAnimals
  42. Maier VK, Feeney CM, Taylor JE, Creech AL, Qiao JW, Szanto A, Das PP, Chevrier N, Cifuentes-Rojas C, Orkin SH, Carr SA, Jaffe JD, Mertins P, Lee JT. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Mol Cell Proteomics. 2015 Jun; 14(6):1435-46. PMID: 25680957.
    Citations: 19     Fields:    Translation:AnimalsCells
  43. Kung JT, Kesner B, An JY, Ahn JY, Cifuentes-Rojas C, Colognori D, Jeon Y, Szanto A, del Rosario BC, Pinter SF, Erwin JA, Lee JT. Locus-specific targeting to the X chromosome revealed by the RNA interactome of CTCF. Mol Cell. 2015 Jan 22; 57(2):361-75. PMID: 25578877.
    Citations: 67     Fields:    Translation:AnimalsCells
  44. Sarma K, Cifuentes-Rojas C, Ergun A, Del Rosario A, Jeon Y, White F, Sadreyev R, Lee JT. ATRX directs binding of PRC2 to Xist RNA and Polycomb targets. Cell. 2014 Nov 06; 159(4):869-83. PMID: 25417162.
    Citations: 98     Fields:    Translation:AnimalsCells
  45. Creech AL, Taylor JE, Maier VK, Wu X, Feeney CM, Udeshi ND, Peach SE, Boehm JS, Lee JT, Carr SA, Jaffe JD. Building the Connectivity Map of epigenetics: chromatin profiling by quantitative targeted mass spectrometry. Methods. 2015 Jan 15; 72:57-64. PMID: 25448295.
    Citations: 24     Fields:    Translation:HumansCells
  46. Payer B, Lee JT. Coupling of X-chromosome reactivation with the pluripotent stem cell state. RNA Biol. 2014; 11(7):798-807. PMID: 25137047.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  47. Cifuentes-Rojas C, Hernandez AJ, Sarma K, Lee JT. Regulatory interactions between RNA and polycomb repressive complex 2. Mol Cell. 2014 Jul 17; 55(2):171-85. PMID: 24882207.
    Citations: 130     Fields:    Translation:AnimalsCells
  48. Yang L, Froberg JE, Lee JT. Long noncoding RNAs: fresh perspectives into the RNA world. Trends Biochem Sci. 2014 Jan; 39(1):35-43. PMID: 24290031.
    Citations: 153     Fields:    Translation:HumansAnimalsCells
  49. Payer B, Rosenberg M, Yamaji M, Yabuta Y, Koyanagi-Aoi M, Hayashi K, Yamanaka S, Saitou M, Lee JT. Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming. Mol Cell. 2013 Dec 26; 52(6):805-18. PMID: 24268575.
    Citations: 44     Fields:    Translation:AnimalsCells
  50. Simon MD, Pinter SF, Fang R, Sarma K, Rutenberg-Schoenberg M, Bowman SK, Kesner BA, Maier VK, Kingston RE, Lee JT. High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation. Nature. 2013 Dec 19; 504(7480):465-469. PMID: 24162848.
    Citations: 164     Fields:    Translation:AnimalsCells
  51. Froberg JE, Yang L, Lee JT. Guided by RNAs: X-inactivation as a model for lncRNA function. J Mol Biol. 2013 Oct 09; 425(19):3698-706. PMID: 23816838.
    Citations: 55     Fields:    Translation:HumansCells
  52. Sun S, Del Rosario BC, Szanto A, Ogawa Y, Jeon Y, Lee JT. Jpx RNA activates Xist by evicting CTCF. Cell. 2013 Jun 20; 153(7):1537-51. PMID: 23791181.
    Citations: 123     Fields:    Translation:AnimalsCells
  53. Lessing D, Anguera MC, Lee JT. X chromosome inactivation and epigenetic responses to cellular reprogramming. Annu Rev Genomics Hum Genet. 2013; 14:85-110. PMID: 23662665.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  54. Sadreyev RI, Yildirim E, Pinter SF, Lee JT. Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6949-54. PMID: 23564346.
    Citations: 5     Fields:    Translation:AnimalsCells
  55. Kung JT, Lee JT. RNA in the loop. Dev Cell. 2013 Mar 25; 24(6):565-7. PMID: 23537627.
    Citations: 3     Fields:    
  56. Lee JT, Bartolomei MS. X-inactivation, imprinting, and long noncoding RNAs in health and disease. Cell. 2013 Mar 14; 152(6):1308-23. PMID: 23498939.
    Citations: 291     Fields:    Translation:HumansAnimals
  57. Kung JT, Colognori D, Lee JT. Long noncoding RNAs: past, present, and future. Genetics. 2013 Mar; 193(3):651-69. PMID: 23463798.
    Citations: 648     Fields:    Translation:HumansAnimalsCells
  58. Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, Lee JT. Xist RNA is a potent suppressor of hematologic cancer in mice. Cell. 2013 Feb 14; 152(4):727-42. PMID: 23415223.
    Citations: 207     Fields:    Translation:AnimalsCells
  59. Lee JT. Epigenetic regulation by long noncoding RNAs. Science. 2012 Dec 14; 338(6113):1435-9. PMID: 23239728.
    Citations: 534     Fields:    Translation:HumansAnimalsCells
  60. Ougland R, Lando D, Jonson I, Dahl JA, Moen MN, Nordstrand LM, Rognes T, Lee JT, Klungland A, Kouzarides T, Larsen E. ALKBH1 is a histone H2A dioxygenase involved in neural differentiation. Stem Cells. 2012 Dec; 30(12):2672-82. PMID: 22961808.
    Citations: 45     Fields:    Translation:AnimalsCells
  61. Pinter SF, Sadreyev RI, Yildirim E, Jeon Y, Ohsumi TK, Borowsky M, Lee JT. Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations. Genome Res. 2012 Oct; 22(10):1864-76. PMID: 22948768.
    Citations: 82     Fields:    Translation:AnimalsCells
  62. Erwin JA, del Rosario B, Payer B, Lee JT. An ex vivo model for imprinting: mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation. Genetics. 2012 Nov; 192(3):857-68. PMID: 22942124.
    Citations: 5     Fields:    Translation:AnimalsCells
  63. Anguera MC, Sadreyev R, Zhang Z, Szanto A, Payer B, Sheridan SD, Kwok S, Haggarty SJ, Sur M, Alvarez J, Gimelbrant A, Mitalipova M, Kirby JE, Lee JT. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell. 2012 Jul 06; 11(1):75-90. PMID: 22770242.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  64. Jeon Y, Sarma K, Lee JT. New and Xisting regulatory mechanisms of X chromosome inactivation. Curr Opin Genet Dev. 2012 Apr; 22(2):62-71. PMID: 22424802.
    Citations: 44     Fields:    Translation:HumansAnimals
  65. Yildirim E, Sadreyev RI, Pinter SF, Lee JT. X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. Nat Struct Mol Biol. 2011 Dec 04; 19(1):56-61. PMID: 22139016.
    Citations: 45     Fields:    Translation:AnimalsCells
  66. Lee JT. Gracefully ageing at 50, X-chromosome inactivation becomes a paradigm for RNA and chromatin control. Nat Rev Mol Cell Biol. 2011 Nov 23; 12(12):815-26. PMID: 22108600.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  67. Anguera MC, Ma W, Clift D, Namekawa S, Kelleher RJ, Lee JT. Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. PLoS Genet. 2011 Sep; 7(9):e1002248. PMID: 21912526.
    Citations: 70     Fields:    Translation:AnimalsCells
  68. Spencer RJ, del Rosario BC, Pinter SF, Lessing D, Sadreyev RI, Lee JT. A boundary element between Tsix and Xist binds the chromatin insulator Ctcf and contributes to initiation of X-chromosome inactivation. Genetics. 2011 Oct; 189(2):441-54. PMID: 21840866.
    Citations: 20     Fields:    Translation:AnimalsCells
  69. Jeon Y, Lee JT. YY1 tethers Xist RNA to the inactive X nucleation center. Cell. 2011 Jul 08; 146(1):119-33. PMID: 21729784.
    Citations: 232     Fields:    Translation:AnimalsCells
  70. Payer B, Lee JT, Namekawa SH. X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells. Hum Genet. 2011 Aug; 130(2):265-80. PMID: 21667284.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  71. Kim DH, Jeon Y, Anguera MC, Lee JT. X-chromosome epigenetic reprogramming in pluripotent stem cells via noncoding genes. Semin Cell Dev Biol. 2011 Jun; 22(4):336-42. PMID: 21376830.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  72. Namekawa SH, Lee JT. Detection of nascent RNA, single-copy DNA and protein localization by immunoFISH in mouse germ cells and preimplantation embryos. Nat Protoc. 2011 Mar; 6(3):270-84. PMID: 21372809.
    Citations: 38     Fields:    Translation:AnimalsCells
  73. Zhao J, Ohsumi TK, Kung JT, Ogawa Y, Grau DJ, Sarma K, Song JJ, Kingston RE, Borowsky M, Lee JT. Genome-wide identification of polycomb-associated RNAs by RIP-seq. Mol Cell. 2010 Dec 22; 40(6):939-53. PMID: 21172659.
    Citations: 462     Fields:    Translation:HumansAnimalsCells
  74. Sarma K, Levasseur P, Aristarkhov A, Lee JT. Locked nucleic acids (LNAs) reveal sequence requirements and kinetics of Xist RNA localization to the X chromosome. Proc Natl Acad Sci U S A. 2010 Dec 21; 107(51):22196-201. PMID: 21135235.
    Citations: 72     Fields:    Translation:AnimalsCells
  75. Nordstrand LM, Svärd J, Larsen E, Nilsen A, Ougland R, Furu K, Lien GF, Rognes T, Namekawa SH, Lee JT, Klungland A. Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects. PLoS One. 2010 Nov 03; 5(11):e13827. PMID: 21072209.
    Citations: 29     Fields:    Translation:Animals
  76. Tian D, Sun S, Lee JT. The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation. Cell. 2010 Oct 29; 143(3):390-403. PMID: 21029862.
    Citations: 206     Fields:    Translation:HumansAnimalsCells
  77. Ahn JY, Lee JT. Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient. BMC Dev Biol. 2010 Aug 20; 10:90. PMID: 20727175.
    Citations: 8     Fields:    Translation:AnimalsCells
  78. Sun S, Fukue Y, Nolen L, Sadreyev R, Lee JT. Characterization of Xpr (Xpct) reveals instability but no effects on X-chromosome pairing or Xist expression. Transcription. 2010 Jul-Aug; 1(1):46-56. PMID: 21327163.
    Citations: 8     Fields:    Translation:AnimalsCells
  79. Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell. 2010 May 28; 141(5):872-83. PMID: 20471072.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  80. Namekawa SH, Payer B, Huynh KD, Jaenisch R, Lee JT. Two-step imprinted X inactivation: repeat versus genic silencing in the mouse. Mol Cell Biol. 2010 Jul; 30(13):3187-205. PMID: 20404085.
    Citations: 55     Fields:    Translation:AnimalsCells
  81. Paro R, Lee JT. Extending the frontiers of epigenetic regulation. Curr Opin Genet Dev. 2010 Apr; 20(2):107-9. PMID: 20382521.
    Citations:    Fields:    Translation:HumansAnimalsCells
  82. Lee JT. The X as model for RNA's niche in epigenomic regulation. Cold Spring Harb Perspect Biol. 2010 Sep; 2(9):a003749. PMID: 20739414.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  83. Erwin JA, Lee JT. Characterization of X-chromosome inactivation status in human pluripotent stem cells. Curr Protoc Stem Cell Biol. 2010 Feb; Chapter 1:Unit 1B.6. PMID: 20127856.
    Citations: 7     Fields:    Translation:HumansCells
  84. Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N. Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009 Nov 06; 16(5):425-38. PMID: 19878874.
    Citations: 410     Fields:    Translation:HumansAnimalsCells
  85. Lee JT. Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome. Genes Dev. 2009 Aug 15; 23(16):1831-42. PMID: 19684108.
    Citations: 163     Fields:    Translation:AnimalsCells
  86. Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT. The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting. Nature. 2009 Jul 02; 460(7251):128-32. PMID: 19536159.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  87. Namekawa SH, Lee JT. XY and ZW: is meiotic sex chromosome inactivation the rule in evolution? PLoS Genet. 2009 May; 5(5):e1000493. PMID: 19461890.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  88. Zhang LF, Ogawa Y, Ahn JY, Namekawa SH, Silva SS, Lee JT. Telomeric RNAs mark sex chromosomes in stem cells. Genetics. 2009 Jul; 182(3):685-98. PMID: 19380904.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  89. Anguera MC, Liu M, Avruch J, Lee JT. Characterization of two Mst1-deficient mouse models. Dev Dyn. 2008 Nov; 237(11):3424-34. PMID: 18942145.
    Citations: 2     Fields:    Translation:Animals
  90. Zhao J, Sun BK, Erwin JA, Song JJ, Lee JT. Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. Science. 2008 Oct 31; 322(5902):750-6. PMID: 18974356.
    Citations: 745     Fields:    Translation:AnimalsCells
  91. Lee JT. Jeannie T. Lee. Curr Biol. 2008 Oct 28; 18(20):R940-1. PMID: 18983954.
    Citations:    Fields:    
  92. Lindroth AM, Park YJ, McLean CM, Dokshin GA, Persson JM, Herman H, Pasini D, Miró X, Donohoe ME, Lee JT, Helin K, Soloway PD. Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus. PLoS Genet. 2008 Aug 01; 4(8):e1000145. PMID: 18670629.
    Citations: 60     Fields:    Translation:AnimalsCells
  93. Ogawa Y, Sun BK, Lee JT. Intersection of the RNA interference and X-inactivation pathways. Science. 2008 Jun 06; 320(5881):1336-41. PMID: 18535243.
    Citations: 114     Fields:    Translation:AnimalsCells
  94. Erwin JA, Lee JT. New twists in X-chromosome inactivation. Curr Opin Cell Biol. 2008 Jun; 20(3):349-55. PMID: 18508252.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  95. Tsai CL, Rowntree RK, Cohen DE, Lee JT. Higher order chromatin structure at the X-inactivation center via looping DNA. Dev Biol. 2008 Jul 15; 319(2):416-25. PMID: 18501343.
    Citations: 36     Fields:    Translation:AnimalsCells
  96. Silva SS, Rowntree RK, Mekhoubad S, Lee JT. X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4820-5. PMID: 18339803.
    Citations: 129     Fields:    Translation:HumansCells
  97. Payer B, Lee JT. X chromosome dosage compensation: how mammals keep the balance. Annu Rev Genet. 2008; 42:733-72. PMID: 18729722.
    Citations: 243     Fields:    Translation:HumansAnimalsCells
  98. Lin H, Gupta V, Vermilyea MD, Falciani F, Lee JT, O'Neill LP, Turner BM. Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes. PLoS Biol. 2007 Dec; 5(12):e326. PMID: 18076287.
    Citations: 89     Fields:    Translation:AnimalsCells
  99. Xu N, Donohoe ME, Silva SS, Lee JT. Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. Nat Genet. 2007 Nov; 39(11):1390-6. PMID: 17952071.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  100. Namekawa SH, VandeBerg JL, McCarrey JR, Lee JT. Sex chromosome silencing in the marsupial male germ line. Proc Natl Acad Sci U S A. 2007 Jun 05; 104(23):9730-5. PMID: 17535928.
    Citations: 46     Fields:    Translation:AnimalsCells
  101. Zhang LF, Huynh KD, Lee JT. Perinucleolar targeting of the inactive X during S phase: evidence for a role in the maintenance of silencing. Cell. 2007 May 18; 129(4):693-706. PMID: 17512404.
    Citations: 147     Fields:    Translation:AnimalsCells
  102. Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A, Jurka J, Kamal M, Mauceli E, Searle SM, Sharpe T, Baker ML, Batzer MA, Benos PV, Belov K, Clamp M, Cook A, Cuff J, Das R, Davidow L, Deakin JE, Fazzari MJ, Glass JL, Grabherr M, Greally JM, Gu W, Hore TA, Huttley GA, Kleber M, Jirtle RL, Koina E, Lee JT, Mahony S, Marra MA, Miller RD, Nicholls RD, Oda M, Papenfuss AT, Parra ZE, Pollock DD, Ray DA, Schein JE, Speed TP, Thompson K, VandeBerg JL, Wade CM, Walker JA, Waters PD, Webber C, Weidman JR, Xie X, Zody MC, Graves JA, Ponting CP, Breen M, Samollow PB, Lander ES, Lindblad-Toh K. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature. 2007 May 10; 447(7141):167-77. PMID: 17495919.
    Citations: 298     Fields:    Translation:HumansAnimalsCells
  103. Kim S, Namekawa SH, Niswander LM, Ward JO, Lee JT, Bardwell VJ, Zarkower D. A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet. 2007 Apr 20; 3(4):e62. PMID: 17447844.
    Citations: 24     Fields:    Translation:AnimalsCells
  104. Davidow LS, Breen M, Duke SE, Samollow PB, McCarrey JR, Lee JT. The search for a marsupial XIC reveals a break with vertebrate synteny. Chromosome Res. 2007; 15(2):137-46. PMID: 17333538.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  105. Donohoe ME, Zhang LF, Xu N, Shi Y, Lee JT. Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell. 2007 Jan 12; 25(1):43-56. PMID: 17218270.
    Citations: 115     Fields:    Translation:HumansAnimalsCells
  106. Cohen DE, Davidow LS, Erwin JA, Xu N, Warshawsky D, Lee JT. The DXPas34 repeat regulates random and imprinted X inactivation. Dev Cell. 2007 Jan; 12(1):57-71. PMID: 17199041.
    Citations: 35     Fields:    Translation:AnimalsCells
  107. Lewis A, Green K, Dawson C, Redrup L, Huynh KD, Lee JT, Hemberger M, Reik W. Epigenetic dynamics of the Kcnq1 imprinted domain in the early embryo. Development. 2006 Nov; 133(21):4203-10. PMID: 17021040.
    Citations: 47     Fields:    Translation:AnimalsCells
  108. Rowntree RK, Lee JT. Mapping of DNA replication origins to noncoding genes of the X-inactivation center. Mol Cell Biol. 2006 May; 26(10):3707-17. PMID: 16648467.
    Citations: 9     Fields:    Translation:AnimalsCells
  109. Namekawa SH, Park PJ, Zhang LF, Shima JE, McCarrey JR, Griswold MD, Lee JT. Postmeiotic sex chromatin in the male germline of mice. Curr Biol. 2006 Apr 04; 16(7):660-7. PMID: 16581510.
    Citations: 192     Fields:    Translation:AnimalsCells
  110. Sun BK, Deaton AM, Lee JT. A transient heterochromatic state in Xist preempts X inactivation choice without RNA stabilization. Mol Cell. 2006 Mar 03; 21(5):617-28. PMID: 16507360.
    Citations: 142     Fields:    Translation:AnimalsCells
  111. Boumil RM, Ogawa Y, Sun BK, Huynh KD, Lee JT. Differential methylation of Xite and CTCF sites in Tsix mirrors the pattern of X-inactivation choice in mice. Mol Cell Biol. 2006 Mar; 26(6):2109-17. PMID: 16507990.
    Citations: 24     Fields:    Translation:AnimalsCells
  112. Xu N, Tsai CL, Lee JT. Transient homologous chromosome pairing marks the onset of X inactivation. Science. 2006 Feb 24; 311(5764):1149-52. PMID: 16424298.
    Citations: 165     Fields:    Translation:AnimalsCells
  113. Lee JT. Regulation of X-chromosome counting by Tsix and Xite sequences. Science. 2005 Jul 29; 309(5735):768-71. PMID: 16051795.
    Citations: 58     Fields:    Translation:AnimalsCells
  114. Huynh KD, Lee JT. X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny. Nat Rev Genet. 2005 May; 6(5):410-8. PMID: 15818384.
    Citations: 43     Fields:    Translation:AnimalsCells
  115. Lee JT. Sex chromosome inactivation: the importance of pairing. Curr Biol. 2005 Apr 12; 15(7):R249-52. PMID: 15823524.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  116. Stavropoulos N, Rowntree RK, Lee JT. Identification of developmentally specific enhancers for Tsix in the regulation of X chromosome inactivation. Mol Cell Biol. 2005 Apr; 25(7):2757-69. PMID: 15767680.
    Citations: 29     Fields:    Translation:AnimalsCells
  117. Shibata S, Lee JT. Tsix transcription- versus RNA-based mechanisms in Xist repression and epigenetic choice. Curr Biol. 2004 Oct 05; 14(19):1747-54. PMID: 15458646.
    Citations: 31     Fields:    Translation:Cells
  118. Huynh KD, Lee JT. Inheritance of a pre-inactivated paternal X chromosome in early mouse embryos. Nature. 2003 Dec 18; 426(6968):857-62. PMID: 14661031.
    Citations: 117     Fields:    Translation:AnimalsCells
  119. Lee JT. X-chromosome inactivation: a multi-disciplinary approach. Semin Cell Dev Biol. 2003 Dec; 14(6):311-2. PMID: 15015737.
    Citations: 3     Fields:    Translation:HumansCells
  120. Lee JT. Functional intergenic transcription: a case study of the X-inactivation centre. Philos Trans R Soc Lond B Biol Sci. 2003 Aug 29; 358(1436):1417-23; discussion 1423. PMID: 14511490.
    Citations: 1     Fields:    Translation:HumansCells
  121. O'Neill LP, Randall TE, Lavender J, Spotswood HT, Lee JT, Turner BM. X-linked genes in female embryonic stem cells carry an epigenetic mark prior to the onset of X inactivation. Hum Mol Genet. 2003 Aug 01; 12(15):1783-90. PMID: 12874099.
    Citations: 8     Fields:    Translation:HumansCells
  122. Lee JT. Molecular biology: Complicity of gene and pseudogene. Nature. 2003 May 01; 423(6935):26-8. PMID: 12721611.
    Citations: 5     Fields:    Translation:AnimalsCells
  123. Lee JT. Molecular links between X-inactivation and autosomal imprinting: X-inactivation as a driving force for the evolution of imprinting? Curr Biol. 2003 Mar 18; 13(6):R242-54. PMID: 12646153.
    Citations: 29     Fields:    Translation:AnimalsCells
  124. Ogawa Y, Lee JT. Xite, X-inactivation intergenic transcription elements that regulate the probability of choice. Mol Cell. 2003 Mar; 11(3):731-43. PMID: 12667455.
    Citations: 88     Fields:    Translation:AnimalsCells
  125. Shibata S, Lee JT. Characterization and quantitation of differential Tsix transcripts: implications for Tsix function. Hum Mol Genet. 2003 Jan 15; 12(2):125-36. PMID: 12499393.
    Citations: 27     Fields:    Translation:AnimalsCells
  126. Lee JT. Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation. Nat Genet. 2002 Sep; 32(1):195-200. PMID: 12145659.
    Citations: 23     Fields:    Translation:AnimalsCells
  127. Cohen DE, Lee JT. X-chromosome inactivation and the search for chromosome-wide silencers. Curr Opin Genet Dev. 2002 Apr; 12(2):219-24. PMID: 11893496.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  128. Lee JT. Is X-chromosome inactivation a homology effect? Adv Genet. 2002; 46:25-48. PMID: 11931227.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  129. Chao W, Huynh KD, Spencer RJ, Davidow LS, Lee JT. CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 2002 Jan 11; 295(5553):345-7. PMID: 11743158.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  130. Lee JT. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix. Cell. 2000 Sep 29; 103(1):17-27. PMID: 11051544.
    Citations: 86     Fields:    Translation:Animals
  131. Lee JT, Lu N. Targeted mutagenesis of Tsix leads to nonrandom X inactivation. Cell. 1999 Oct 01; 99(1):47-57. PMID: 10520993.
    Citations: 179     Fields:    Translation:AnimalsCells
  132. Lee JT, Davidow LS, Warshawsky D. Tsix, a gene antisense to Xist at the X-inactivation centre. Nat Genet. 1999 Apr; 21(4):400-4. PMID: 10192391.
    Citations: 288     Fields:    Translation:HumansAnimalsCells
  133. Lee JT, Lu N, Han Y. Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3836-41. PMID: 10097124.
    Citations: 38     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.