Harvard Catalyst Profiles

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Michael Joseph Eck, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA242461 (ECK, MICHAEL J) Sep 1, 2019 - Aug 31, 2026
    Structure, mechanism, and pharmacology of BRAF and its partners in the RAS/RAF/MAP kinase pathway
    Role: Principal Investigator
  2. R01CA201049 (ECK, MICHAEL J) Dec 1, 2015 - Nov 30, 2025
    Discovery and optimization of novel mutant-selective allosteric inhibitors of EGFR T790M
    Role: Principal Investigator
  3. R01GM110352 (ECK, MICHAEL J) Aug 10, 2014 - Mar 31, 2019
    Structure and regulation of non-receptor tyrosine kinases
    Role: Principal Investigator
  4. P01CA154303 (MEYERSON, MATTHEW L.) May 11, 2012 - Aug 31, 2022
    Protein Kinase Therapeutic Targets for Non-Small Cell Lung Carcinoma
    Role: Co-Principal Investigator
  5. R01CA116020 (ECK, MICHAEL J) Jul 1, 2005 - Mar 31, 2023
    Inhibitor-sensitive and -resistant EGFR mutants from lung cancer and glioblastoma
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Amrhein JA, Beyett TS, Feng WW, Krämer A, Weckesser J, Schaeffner IK, Rana JK, Jänne PA, Eck MJ, Knapp S, Hanke T. Macrocyclization of Quinazoline-Based EGFR Inhibitors Leads to Exclusive Mutant Selectivity for EGFR L858R and Del19. J Med Chem. 2022 Nov 16. PMID: 36384036.
    Citations:    Fields:    
  2. Bae H, Viennet T, Park E, Chu N, Salguero A, Eck MJ, Arthanari H, Cole PA. PH domain-mediated autoinhibition and oncogenic activation of Akt. Elife. 2022 08 15; 11. PMID: 35968932; PMCID: PMC9417420.
    Citations:    Fields:    Translation:Cells
  3. Hauseman ZJ, Fodor M, Dhembi A, Viscomi J, Egli D, Bleu M, Katz S, Park E, Jang DM, Porter KA, Meili F, Guo H, Kerr G, Mollé S, Velez-Vega C, Beyer KS, Galli GG, Maira SM, Stams T, Clark K, Eck MJ, Tordella L, Thoma CR, King DA. Structure of the MRAS-SHOC2-PP1C phosphatase complex. Nature. 2022 09; 609(7926):416-423. PMID: 35830882; PMCID: PMC9452295.
    Citations:    Fields:    
  4. Beyett TS, To C, Heppner DE, Rana JK, Schmoker AM, Jang J, De Clercq DJH, Gomez G, Scott DA, Gray NS, Jänne PA, Eck MJ. Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors. Nat Commun. 2022 05 09; 13(1):2530. PMID: 35534503; PMCID: PMC9085736.
    Citations:    Fields:    Translation:Humans
  5. Son J, Jang J, Beyett TS, Eum Y, Haikala HM, Verano A, Lin M, Hatcher JM, Kwiatkowski NP, Eser PÖ, Poitras MJ, Wang S, Xu M, Gokhale PC, Cameron MD, Eck MJ, Gray NS, Jänne PA. A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer. Cancer Res. 2022 04 15; 82(8):1633-1645. PMID: 35149586.
    Citations:    Fields:    Translation:Humans
  6. To C, Beyett TS, Jang J, Feng WW, Bahcall M, Haikala HM, Shin BH, Heppner DE, Rana JK, Leeper BA, Soroko KM, Poitras MJ, Gokhale PC, Kobayashi Y, Wahid K, Kurppa KJ, Gero TW, Cameron MD, Ogino A, Mushajiang M, Xu C, Zhang Y, Scott DA, Eck MJ, Gray NS, Jänne PA. An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer. Nat Cancer. 2022 04; 3(4):402-417. PMID: 35422503; PMCID: PMC9248923.
    Citations: 4     Translation:Humans
  7. Gero TW, Heppner DE, Beyett TS, To C, Azevedo SC, Jang J, Bunnell T, Feru F, Li Z, Shin BH, Soroko KM, Gokhale PC, Gray NS, Jänne PA, Eck MJ, Scott DA. Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorg Med Chem Lett. 2022 07 15; 68:128718. PMID: 35378251.
    Citations:    Fields:    Translation:HumansCells
  8. Wittlinger F, Heppner DE, To C, Günther M, Shin BH, Rana JK, Schmoker AM, Beyett TS, Berger LM, Berger BT, Bauer N, Vasta JD, Corona CR, Robers MB, Knapp S, Jänne PA, Eck MJ, Laufer SA. Design of a "Two-in-One" Mutant-Selective Epidermal Growth Factor Receptor Inhibitor That Spans the Orthosteric and Allosteric Sites. J Med Chem. 2022 01 27; 65(2):1370-1383. PMID: 34668706; PMCID: PMC9255384.
    Citations: 1     Fields:    Translation:HumansCells
  9. Dempsey DR, Viennet T, Iwase R, Park E, Henriquez S, Chen Z, Jeliazkov JR, Palanski BA, Phan KL, Coote P, Gray JJ, Eck MJ, Gabelli SB, Arthanari H, Cole PA. The structural basis of PTEN regulation by multi-site phosphorylation. Nat Struct Mol Biol. 2021 10; 28(10):858-868. PMID: 34625746; PMCID: PMC8549118.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Gonzalez-Del Pino GL, Li K, Park E, Schmoker AM, Ha BH, Eck MJ. Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation. Proc Natl Acad Sci U S A. 2021 09 07; 118(36). PMID: 34470822; PMCID: PMC8433572.
    Citations: 4     Fields:    Translation:HumansCells
  11. Nakamura IT, Kohsaka S, Ikegami M, Ikeuchi H, Ueno T, Li K, Beyett TS, Koyama T, Shimizu T, Yamamoto N, Takahashi F, Takahashi K, Eck MJ, Mano H. Comprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer. NPJ Precis Oncol. 2021 Jul 16; 5(1):66. PMID: 34272467; PMCID: PMC8285406.
    Citations: 3     
  12. Heppner DE, Eck MJ. A structural perspective on targeting the RTK/Ras/MAP kinase pathway in cancer. Protein Sci. 2021 08; 30(8):1535-1553. PMID: 34008902; PMCID: PMC8284588.
    Citations: 6     Fields:    Translation:HumansCells
  13. Merk DJ, Zhou P, Cohen SM, Pazyra-Murphy MF, Hwang GH, Rehm KJ, Alfaro J, Reid CM, Zhao X, Park E, Xu PX, Chan JA, Eck MJ, Nazemi KJ, Harwell CC, Segal RA. The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors. Dev Neurosci. 2020; 42(5-6):170-186. PMID: 33472197; PMCID: PMC8118085.
    Citations: 4     Fields:    Translation:AnimalsCells
  14. Jang J, To C, De Clercq DJH, Park E, Ponthier CM, Shin BH, Mushajiang M, Nowak RP, Fischer ES, Eck MJ, Jänne PA, Gray NS. Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations. Angew Chem Int Ed Engl. 2020 08 17; 59(34):14481-14489. PMID: 32510788.
    Citations: 11     Fields:    Translation:HumansCells
  15. Hsu JW, Bai M, Li K, Yang JS, Chu N, Cole PA, Eck MJ, Li J, Hsu VW. The protein kinase Akt acts as a coat adaptor in endocytic recycling. Nat Cell Biol. 2020 08; 22(8):927-933. PMID: 32541877.
    Citations: 4     Fields:    Translation:HumansCells
  16. Heppner DE, Günther M, Wittlinger F, Laufer SA, Eck MJ. Structural Basis for EGFR Mutant Inhibition by Trisubstituted Imidazole Inhibitors. J Med Chem. 2020 04 23; 63(8):4293-4305. PMID: 32243152.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. De Clercq DJH, Heppner DE, To C, Jang J, Park E, Yun CH, Mushajiang M, Shin BH, Gero TW, Scott DA, Jänne PA, Eck MJ, Gray NS. Discovery and Optimization of Dibenzodiazepinones as Allosteric Mutant-Selective EGFR Inhibitors. ACS Med Chem Lett. 2019 Nov 14; 10(11):1549-1553. PMID: 31749909.
    Citations: 12     
  18. Park E, Rawson S, Li K, Kim BW, Ficarro SB, Pino GG, Sharif H, Marto JA, Jeon H, Eck MJ. Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes. Nature. 2019 11; 575(7783):545-550. PMID: 31581174; PMCID: PMC7014971.
    Citations: 70     Fields:    Translation:HumansCells
  19. Heppner DE, Beyett TS, Eck MJ. A driving test for oncogenic mutations. J Biol Chem. 2019 06 14; 294(24):9390-9391. PMID: 31201242.
    Citations:    Fields:    Translation:HumansCells
  20. To C, Jang J, Chen T, Park E, Mushajiang M, De Clercq DJH, Xu M, Wang S, Cameron MD, Heppner DE, Shin BH, Gero TW, Yang A, Dahlberg SE, Wong KK, Eck MJ, Gray NS, Jänne PA. Single and Dual Targeting of Mutant EGFR with an Allosteric Inhibitor. Cancer Discov. 2019 07; 9(7):926-943. PMID: 31092401; PMCID: PMC6664433.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  21. McNally R, Li Q, Li K, Dekker C, Vangrevelinghe E, Jones M, Chène P, Machauer R, Radimerski T, Eck MJ. Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain. ACS Chem Biol. 2019 04 19; 14(4):587-593. PMID: 30763067.
    Citations: 6     Fields:    Translation:HumansCells
  22. Jang J, Son J, Park E, Kosaka T, Saxon JA, De Clercq DJH, Choi HG, Tanizaki J, Eck MJ, Jänne PA, Gray NS. Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor. Angew Chem Int Ed Engl. 2018 09 03; 57(36):11629-11633. PMID: 29978938; PMCID: PMC6118895.
    Citations: 10     Fields:    Translation:HumansCells
  23. Papadakis G, Murasova P, Hamiot A, Tsougeni K, Kaprou G, Eck M, Rabus D, Bilkova Z, Dupuy B, Jobst G, Tserepi A, Gogolides E, Gizeli E. Micro-nano-bio acoustic system for the detection of foodborne pathogens in real samples. Biosens Bioelectron. 2018 Jul 15; 111:52-58. PMID: 29635118.
    Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  24. Wang Y, Li YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao JJ. Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 2018 03 12; 7. PMID: 29528283.
    Citations: 4     Fields:    
  25. Huang HT, Seo HS, Zhang T, Wang Y, Jiang B, Li Q, Buckley DL, Nabet B, Roberts JM, Paulk J, Dastjerdi S, Winter GE, McLauchlan H, Moran J, Bradner JE, Eck MJ, Dhe-Paganon S, Zhao JJ, Gray NS. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 09 19; 6. PMID: 28926338; PMCID: PMC5605198.
    Citations: 37     Fields:    Translation:HumansCells
  26. Boczkowska M, Yurtsever Z, Rebowski G, Eck MJ, Dominguez R. Crystal Structure of Leiomodin 2 in Complex with Actin: A Structural and Functional Reexamination. Biophys J. 2017 Aug 22; 113(4):889-899. PMID: 28834725.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  27. Zhang J, Gao X, Schmit F, Adelmant G, Eck MJ, Marto JA, Zhao JJ, Roberts TM. CRKL Mediates p110ß-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells. Cell Rep. 2017 07 18; 20(3):549-557. PMID: 28723560.
    Citations: 15     Fields:    Translation:HumansCells
  28. Kosaka T, Tanizaki J, Paranal RM, Endoh H, Lydon C, Capelletti M, Repellin CE, Choi J, Ogino A, Calles A, Ercan D, Redig AJ, Bahcall M, Oxnard GR, Eck MJ, Jänne PA. Response Heterogeneity of EGFR and HER2 Exon 20 Insertions to Covalent EGFR and HER2 Inhibitors. Cancer Res. 2017 05 15; 77(10):2712-2721. PMID: 28363995; PMCID: PMC5596996.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  29. Cai W, Sakaguchi M, Kleinridders A, Gonzalez-Del Pino G, Dreyfuss JM, O'Neill BT, Ramirez AK, Pan H, Winnay JN, Boucher J, Eck MJ, Kahn CR. Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun. 2017 03 27; 8:14892. PMID: 28345670.
    Citations: 47     Fields:    Translation:AnimalsCells
  30. Ficarro SB, Browne CM, Card JD, Alexander WM, Zhang T, Park E, McNally R, Dhe-Paganon S, Seo HS, Lamberto I, Eck MJ, Buhrlage SJ, Gray NS, Marto JA. Leveraging Gas-Phase Fragmentation Pathways for Improved Identification and Selective Detection of Targets Modified by Covalent Probes. Anal Chem. 2016 12 20; 88(24):12248-12254. PMID: 28193034.
    Citations: 13     Fields:    Translation:HumansCells
  31. Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9810-5. PMID: 27528663; PMCID: PMC5024598.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  32. McNally R, Toms AV, Eck MJ. Crystal Structure of the FERM-SH2 Module of Human Jak2. PLoS One. 2016; 11(5):e0156218. PMID: 27227461.
    Citations: 14     Fields:    Translation:HumansCells
  33. Jia Y, Yun CH, Park E, Ercan D, Manuia M, Juarez J, Xu C, Rhee K, Chen T, Zhang H, Palakurthi S, Jang J, Lelais G, DiDonato M, Bursulaya B, Michellys PY, Epple R, Marsilje TH, McNeill M, Lu W, Harris J, Bender S, Wong KK, Jänne PA, Eck MJ. Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors. Nature. 2016 06 02; 534(7605):129-32. PMID: 27251290.
    Citations: 213     Fields:    Translation:AnimalsCells
  34. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396.
    Citations: 68     Fields:    
  35. Fischer ES, Park E, Eck MJ, Thomä NH. SPLINTS: small-molecule protein ligand interface stabilizers. Curr Opin Struct Biol. 2016 Apr; 37:115-22. PMID: 26829757; PMCID: PMC4834252.
    Citations: 15     Fields:    Translation:Cells
  36. Begley MJ, Yun CH, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I, Cantley LC. EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src. Nat Struct Mol Biol. 2015 Dec; 22(12):983-90. PMID: 26551075; PMCID: PMC4824005.
    Citations: 22     Fields:    Translation:HumansCells
  37. Tan L, Akahane K, McNally R, Reyskens KM, Ficarro SB, Liu S, Herter-Sprie GS, Koyama S, Pattison MJ, Labella K, Johannessen L, Akbay EA, Wong KK, Frank DA, Marto JA, Look TA, Arthur JS, Eck MJ, Gray NS. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27; 58(16):6589-606. PMID: 26258521; PMCID: PMC4777322.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  38. Park E, Kim N, Ficarro SB, Zhang Y, Lee BI, Cho A, Kim K, Park AKJ, Park WY, Murray B, Meyerson M, Beroukhim R, Marto JA, Cho J, Eck MJ. Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6. Nat Struct Mol Biol. 2015 Sep; 22(9):703-711. PMID: 26280531.
    Citations: 26     Fields:    Translation:HumansCells
  39. Wu SC, Li LS, Kopp N, Montero J, Chapuy B, Yoda A, Christie AL, Liu H, Christodoulou A, van Bodegom D, van der Zwet J, Layer JV, Tivey T, Lane AA, Ryan JA, Ng SY, DeAngelo DJ, Stone RM, Steensma D, Wadleigh M, Harris M, Mandon E, Ebel N, Andraos R, Romanet V, Dölemeyer A, Sterker D, Zender M, Rodig SJ, Murakami M, Hofmann F, Kuo F, Eck MJ, Silverman LB, Sallan SE, Letai A, Baffert F, Vangrevelinghe E, Radimerski T, Gaul C, Weinstock DM. Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia. Cancer Cell. 2015 Jul 13; 28(1):29-41. PMID: 26175414.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  40. Wu H, Hu C, Wang A, Weisberg EL, Chen Y, Yun CH, Wang W, Liu Y, Liu X, Tian B, Wang J, Zhao Z, Liang Y, Li B, Wang L, Wang B, Chen C, Buhrlage SJ, Qi Z, Zou F, Nonami A, Li Y, Fernandes SM, Adamia S, Stone RM, Galinsky IA, Wang X, Yang G, Griffin JD, Brown JR, Eck MJ, Liu J, Gray NS, Liu Q. Discovery of a BTK/MNK dual inhibitor for lymphoma and leukemia. Leukemia. 2016 Jan; 30(1):173-81. PMID: 26165234; PMCID: PMC4987129.
    Citations: 15     Fields:    Translation:HumansCells
  41. Park E, Graziano BR, Zheng W, Garabedian M, Goode BL, Eck MJ. Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif. Structure. 2015 Aug 04; 23(8):1492-1499. PMID: 26118535.
    Citations: 8     Fields:    Translation:AnimalsCells
  42. Ercan D, Choi HG, Yun CH, Capelletti M, Xie T, Eck MJ, Gray NS, Jänne PA. EGFR Mutations and Resistance to Irreversible Pyrimidine-Based EGFR Inhibitors. Clin Cancer Res. 2015 Sep 01; 21(17):3913-23. PMID: 25948633; PMCID: PMC4791951.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  43. Hu Y, Petit SA, Ficarro SB, Toomire KJ, Xie A, Lim E, Cao SA, Park E, Eck MJ, Scully R, Brown M, Marto JA, Livingston DM. PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair. Cancer Discov. 2014 Dec; 4(12):1430-47. PMID: 25252691.
    Citations: 60     Fields:    Translation:HumansCells
  44. Goñi GM, Epifano C, Boskovic J, Camacho-Artacho M, Zhou J, Bronowska A, Martín MT, Eck MJ, Kremer L, Gräter F, Gervasio FL, Perez-Moreno M, Lietha D. Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3177-86. PMID: 25049397.
    Citations: 58     Fields:    Translation:HumansCells
  45. Cho J, Bass AJ, Lawrence MS, Cibulskis K, Cho A, Lee SN, Yamauchi M, Wagle N, Pochanard P, Kim N, Park AK, Won J, Hur HS, Greulich H, Ogino S, Sougnez C, Voet D, Tabernero J, Jimenez J, Baselga J, Gabriel SB, Lander ES, Getz G, Eck MJ, Park WY, Meyerson M. Colon cancer-derived oncogenic EGFR G724S mutant identified by whole genome sequence analysis is dependent on asymmetric dimerization and sensitive to cetuximab. Mol Cancer. 2014 Jun 04; 13:141. PMID: 24894453.
    Citations: 15     Fields:    Translation:HumansCells
  46. Wang Y, Lee YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao JJ. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 2014 May 20; 3:e01763. PMID: 24844244; PMCID: PMC4059381.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  47. McNally R, Eck MJ. JAK-cytokine receptor recognition, unboxed. Nat Struct Mol Biol. 2014 May; 21(5):431-3. PMID: 24799036.
    Citations: 7     Fields:    Translation:Humans
  48. Zhu Z, Aref AR, Cohoon TJ, Barbie TU, Imamura Y, Yang S, Moody SE, Shen RR, Schinzel AC, Thai TC, Reibel JB, Tamayo P, Godfrey JT, Qian ZR, Page AN, Maciag K, Chan EM, Silkworth W, Labowsky MT, Rozhansky L, Mesirov JP, Gillanders WE, Ogino S, Hacohen N, Gaudet S, Eck MJ, Engelman JA, Corcoran RB, Wong KK, Hahn WC, Barbie DA. Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit. Cancer Discov. 2014 Apr; 4(4):452-65. PMID: 24444711; PMCID: PMC3980023.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  49. Yasuda H, Park E, Yun CH, Sng NJ, Lucena-Araujo AR, Yeo WL, Huberman MS, Cohen DW, Nakayama S, Ishioka K, Yamaguchi N, Hanna M, Oxnard GR, Lathan CS, Moran T, Sequist LV, Chaft JE, Riely GJ, Arcila ME, Soo RA, Meyerson M, Eck MJ, Kobayashi SS, Costa DB. Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer. Sci Transl Med. 2013 Dec 18; 5(216):216ra177. PMID: 24353160; PMCID: PMC3954775.
    Citations: 174     Fields:    Translation:HumansCells
  50. Cho J, Chen L, Sangji N, Okabe T, Yonesaka K, Francis JM, Flavin RJ, Johnson W, Kwon J, Yu S, Greulich H, Johnson BE, Eck MJ, Jänne PA, Wong KK, Meyerson M. Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization. Cancer Res. 2013 Nov 15; 73(22):6770-9. PMID: 24063894.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  51. Red Brewer M, Yun CH, Lai D, Lemmon MA, Eck MJ, Pao W. Mechanism for activation of mutated epidermal growth factor receptors in lung cancer. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):E3595-604. PMID: 24019492.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  52. Toms AV, Deshpande A, McNally R, Jeong Y, Rogers JM, Kim CU, Gruner SM, Ficarro SB, Marto JA, Sattler M, Griffin JD, Eck MJ. Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat Struct Mol Biol. 2013 Oct; 20(10):1221-3. PMID: 24013208.
    Citations: 36     Fields:    Translation:HumansCells
  53. Zhang C, Lopez MS, Dar AC, Ladow E, Finkbeiner S, Yun CH, Eck MJ, Shokat KM. Structure-guided inhibitor design expands the scope of analog-sensitive kinase technology. ACS Chem Biol. 2013 Sep 20; 8(9):1931-8. PMID: 23841803.
    Citations: 27     Fields:    Translation:Humans
  54. Tu D, Zhu Z, Zhou AY, Yun CH, Lee KE, Toms AV, Li Y, Dunn GP, Chan E, Thai T, Yang S, Ficarro SB, Marto JA, Jeon H, Hahn WC, Barbie DA, Eck MJ. Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep. 2013 Mar 28; 3(3):747-58. PMID: 23453972; PMCID: PMC3863638.
    Citations: 75     Fields:    Translation:HumansCells
  55. Tu D, Graziano BR, Park E, Zheng W, Li Y, Goode BL, Eck MJ. Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6. Proc Natl Acad Sci U S A. 2012 Dec 11; 109(50):E3424-33. PMID: 23161908.
    Citations: 20     Fields:    Translation:AnimalsCells
  56. Greulich H, Kaplan B, Mertins P, Chen TH, Tanaka KE, Yun CH, Zhang X, Lee SH, Cho J, Ambrogio L, Liao R, Imielinski M, Banerji S, Berger AH, Lawrence MS, Zhang J, Pho NH, Walker SR, Winckler W, Getz G, Frank D, Hahn WC, Eck MJ, Mani DR, Jaffe JD, Carr SA, Wong KK, Meyerson M. Functional analysis of receptor tyrosine kinase mutations in lung cancer identifies oncogenic extracellular domain mutations of ERBB2. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14476-81. PMID: 22908275.
    Citations: 136     Fields:    Translation:AnimalsCells
  57. Yin Q, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, Chen ZJ, Wu H. Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell. 2012 Jun 29; 46(6):735-45. PMID: 22705373.
    Citations: 109     Fields:    Translation:HumansCells
  58. Eck MJ, Hahn WC. EGFR in limbo. Cell. 2012 May 11; 149(4):735-7. PMID: 22579278.
    Citations: 2     Fields:    
  59. Ni J, Liu Q, Xie S, Carlson C, Von T, Vogel K, Riddle S, Benes C, Eck M, Roberts T, Gray N, Zhao J. Functional characterization of an isoform-selective inhibitor of PI3K-p110ß as a potential anticancer agent. Cancer Discov. 2012 May; 2(5):425-33. PMID: 22588880.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  60. Weigert O, Lane AA, Bird L, Kopp N, Chapuy B, van Bodegom D, Toms AV, Marubayashi S, Christie AL, McKeown M, Paranal RM, Bradner JE, Yoda A, Gaul C, Vangrevelinghe E, Romanet V, Murakami M, Tiedt R, Ebel N, Evrot E, De Pover A, Régnier CH, Erdmann D, Hofmann F, Eck MJ, Sallan SE, Levine RL, Kung AL, Baffert F, Radimerski T, Weinstock DM. Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. J Exp Med. 2012 Feb 13; 209(2):259-73. PMID: 22271575.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  61. He M, Capelletti M, Nafa K, Yun CH, Arcila ME, Miller VA, Ginsberg MS, Zhao B, Kris MG, Eck MJ, Jänne PA, Ladanyi M, Oxnard GR. EGFR exon 19 insertions: a new family of sensitizing EGFR mutations in lung adenocarcinoma. Clin Cancer Res. 2012 Mar 15; 18(6):1790-7. PMID: 22190593.
    Citations: 55     Fields:    Translation:HumansCells
  62. Chang F, Lemmon C, Lietha D, Eck M, Romer L. Tyrosine phosphorylation of Rac1: a role in regulation of cell spreading. PLoS One. 2011; 6(12):e28587. PMID: 22163037.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  63. Vizcarra CL, Kreutz B, Rodal AA, Toms AV, Lu J, Zheng W, Quinlan ME, Eck MJ. Structure and function of the interacting domains of Spire and Fmn-family formins. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11884-9. PMID: 21730168.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  64. Hammerman PS, Sos ML, Ramos AH, Xu C, Dutt A, Zhou W, Brace LE, Woods BA, Lin W, Zhang J, Deng X, Lim SM, Heynck S, Peifer M, Simard JR, Lawrence MS, Onofrio RC, Salvesen HB, Seidel D, Zander T, Heuckmann JM, Soltermann A, Moch H, Koker M, Leenders F, Gabler F, Querings S, Ansén S, Brambilla E, Brambilla C, Lorimier P, Brustugun OT, Helland A, Petersen I, Clement JH, Groen H, Timens W, Sietsma H, Stoelben E, Wolf J, Beer DG, Tsao MS, Hanna M, Hatton C, Eck MJ, Janne PA, Johnson BE, Winckler W, Greulich H, Bass AJ, Cho J, Rauh D, Gray NS, Wong KK, Haura EB, Thomas RK, Meyerson M. Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer. Cancer Discov. 2011 Jun; 1(1):78-89. PMID: 22328973.
    Citations: 214     Fields:    Translation:HumansAnimalsCells
  65. Tu D, Li Y, Song HK, Toms AV, Gould CJ, Ficarro SB, Marto JA, Goode BL, Eck MJ. Crystal structure of a coiled-coil domain from human ROCK I. PLoS One. 2011 Mar 21; 6(3):e18080. PMID: 21445309.
    Citations: 21     Fields:    Translation:HumansCells
  66. Smurnyy Y, Toms AV, Hickson GR, Eck MJ, Eggert US. Binucleine 2, an isoform-specific inhibitor of Drosophila Aurora B kinase, provides insights into the mechanism of cytokinesis. ACS Chem Biol. 2010 Nov 19; 5(11):1015-20. PMID: 20804174; PMCID: PMC3039078.
    Citations: 23     Fields:    Translation:AnimalsCells
  67. Frame MC, Patel H, Serrels B, Lietha D, Eck MJ. The FERM domain: organizing the structure and function of FAK. Nat Rev Mol Cell Biol. 2010 Nov; 11(11):802-14. PMID: 20966971.
    Citations: 168     Fields:    Translation:HumansAnimalsCells
  68. Sasaki T, Okuda K, Zheng W, Butrynski J, Capelletti M, Wang L, Gray NS, Wilner K, Christensen JG, Demetri G, Shapiro GI, Rodig SJ, Eck MJ, Jänne PA. The neuroblastoma-associated F1174L ALK mutation causes resistance to an ALK kinase inhibitor in ALK-translocated cancers. Cancer Res. 2010 Dec 15; 70(24):10038-43. PMID: 21030459.
    Citations: 144     Fields:    Translation:HumansCells
  69. Nezami A, Poy F, Toms A, Zheng W, Eck MJ. Crystal structure of a complex between amino and carboxy terminal fragments of mDia1: insights into autoinhibition of diaphanous-related formins. PLoS One. 2010 Sep 30; 5(9). PMID: 20927338.
    Citations: 22     Fields:    Translation:AnimalsCells
  70. Choi WS, Jeong BC, Joo YJ, Lee MR, Kim J, Eck MJ, Song HK. Structural basis for the recognition of N-end rule substrates by the UBR box of ubiquitin ligases. Nat Struct Mol Biol. 2010 Oct; 17(10):1175-81. PMID: 20835240.
    Citations: 61     Fields:    Translation:AnimalsCells
  71. Zhou W, Ercan D, Chen L, Yun CH, Li D, Capelletti M, Cortot AB, Chirieac L, Iacob RE, Padera R, Engen JR, Wong KK, Eck MJ, Gray NS, Jänne PA. Novel mutant-selective EGFR kinase inhibitors against EGFR T790M. Nature. 2009 Dec 24; 462(7276):1070-4. PMID: 20033049.
    Citations: 350     Fields:    Translation:AnimalsCells
  72. Eck MJ, Yun CH. Structural and mechanistic underpinnings of the differential drug sensitivity of EGFR mutations in non-small cell lung cancer. Biochim Biophys Acta. 2010 Mar; 1804(3):559-66. PMID: 20026433.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  73. Hohendorff B, Eck M, Mühldorfer M, Fodor S, Schmitt R, Prommersberger KJ. [Palmar wrist arthroscopy for evaluation of concomitant carpal lesions in operative treatment of distal intraarticular radius fractures]. Handchir Mikrochir Plast Chir. 2009 Oct; 41(5):295-9. PMID: 19790024.
    Citations: 6     Fields:    Translation:Humans
  74. Eck MJ, Manley PW. The interplay of structural information and functional studies in kinase drug design: insights from BCR-Abl. Curr Opin Cell Biol. 2009 Apr; 21(2):288-95. PMID: 19217274.
    Citations: 18     Fields:    Translation:HumansCells
  75. Lietha D, Eck MJ. Crystal structures of the FAK kinase in complex with TAE226 and related bis-anilino pyrimidine inhibitors reveal a helical DFG conformation. PLoS One. 2008; 3(11):e3800. PMID: 19030106.
    Citations: 23     Fields:    Translation:AnimalsCells
  76. Swanson KD, Tang Y, Ceccarelli DF, Poy F, Sliwa JP, Neel BG, Eck MJ. The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch. Mol Cell. 2008 Nov 21; 32(4):564-75. PMID: 19026786.
    Citations: 24     Fields:    Translation:AnimalsCells
  77. Yun CH, Mengwasser KE, Toms AV, Woo MS, Greulich H, Wong KK, Meyerson M, Eck MJ. The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2070-5. PMID: 18227510.
    Citations: 672     Fields:    Translation:AnimalsCells
  78. Cai X, Lietha D, Ceccarelli DF, Karginov AV, Rajfur Z, Jacobson K, Hahn KM, Eck MJ, Schaller MD. Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol. 2008 Jan; 28(1):201-14. PMID: 17967873.
    Citations: 85     Fields:    Translation:HumansCells
  79. Li D, Shimamura T, Ji H, Chen L, Haringsma HJ, McNamara K, Liang MC, Perera SA, Zaghlul S, Borgman CL, Kubo S, Takahashi M, Sun Y, Chirieac LR, Padera RF, Lindeman NI, Jänne PA, Thomas RK, Meyerson ML, Eck MJ, Engelman JA, Shapiro GI, Wong KK. Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy. Cancer Cell. 2007 Jul; 12(1):81-93. PMID: 17613438.
    Citations: 100     Fields:    Translation:AnimalsCells
  80. Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ. Structural basis for the autoinhibition of focal adhesion kinase. Cell. 2007 Jun 15; 129(6):1177-87. PMID: 17574028; PMCID: PMC2077847.
    Citations: 197     Fields:    Translation:HumansAnimalsCells
  81. Lu J, Meng W, Poy F, Maiti S, Goode BL, Eck MJ. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. J Mol Biol. 2007 Jun 22; 369(5):1258-69. PMID: 17482208; PMCID: PMC1939941.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  82. Blair JA, Rauh D, Kung C, Yun CH, Fan QW, Rode H, Zhang C, Eck MJ, Weiss WA, Shokat KM. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat Chem Biol. 2007 Apr; 3(4):229-38. PMID: 17334377.
    Citations: 59     Fields:    Translation:AnimalsCells
  83. Yun CH, Boggon TJ, Li Y, Woo MS, Greulich H, Meyerson M, Eck MJ. Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell. 2007 Mar; 11(3):217-27. PMID: 17349580; PMCID: PMC1939942.
    Citations: 351     Fields:    Translation:HumansCells
  84. Goode BL, Eck MJ. Mechanism and function of formins in the control of actin assembly. Annu Rev Biochem. 2007; 76:593-627. PMID: 17373907.
    Citations: 383     Fields:    Translation:HumansAnimalsCells
  85. Ji H, Zhao X, Yuza Y, Shimamura T, Li D, Protopopov A, Jung BL, McNamara K, Xia H, Glatt KA, Thomas RK, Sasaki H, Horner JW, Eck M, Mitchell A, Sun Y, Al-Hashem R, Bronson RT, Rabindran SK, Discafani CM, Maher E, Shapiro GI, Meyerson M, Wong KK. Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7817-22. PMID: 16672372.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  86. Nezami AG, Poy F, Eck MJ. Structure of the autoinhibitory switch in formin mDia1. Structure. 2006 Feb; 14(2):257-63. PMID: 16472745.
    Citations: 51     Fields:    Translation:Cells
  87. Ceccarelli DF, Song HK, Poy F, Schaller MD, Eck MJ. Crystal structure of the FERM domain of focal adhesion kinase. J Biol Chem. 2006 Jan 06; 281(1):252-9. PMID: 16221668.
    Citations: 64     Fields:    Translation:AnimalsCells
  88. Boggon TJ, Li Y, Manley PW, Eck MJ. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood. 2005 Aug 01; 106(3):996-1002. PMID: 15831699; PMCID: PMC1895152.
    Citations: 50     Fields:    Translation:HumansCells
  89. Levine RL, Wadleigh M, Cools J, Ebert BL, Wernig G, Huntly BJ, Boggon TJ, Wlodarska I, Clark JJ, Moore S, Adelsperger J, Koo S, Lee JC, Gabriel S, Mercher T, D'Andrea A, Fröhling S, Döhner K, Marynen P, Vandenberghe P, Mesa RA, Tefferi A, Griffin JD, Eck MJ, Sellers WR, Meyerson M, Golub TR, Lee SJ, Gilliland DG. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell. 2005 Apr; 7(4):387-97. PMID: 15837627.
    Citations: 1014     Fields:    Translation:HumansCells
  90. Kobayashi S, Boggon TJ, Dayaram T, Jänne PA, Kocher O, Meyerson M, Johnson BE, Eck MJ, Tenen DG, Halmos B. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med. 2005 Feb 24; 352(8):786-92. PMID: 15728811.
    Citations: 1527     Fields:    Translation:HumansCells
  91. Honig A, Rieger L, Kristen P, Eck M, Frambach T, Tschammler A, Caffier H, Dietl J. A case of metastasizing invasive hydatidiform mole. Is less--less good? Review of the literature with regard to adequate treatment. Eur J Gynaecol Oncol. 2005; 26(2):158-62. PMID: 15857020.
    Citations:    Fields:    Translation:Humans
  92. Boggon TJ, Eck MJ. Structure and regulation of Src family kinases. Oncogene. 2004 Oct 18; 23(48):7918-27. PMID: 15489910.
    Citations: 284     Fields:    Translation:HumansAnimalsCells
  93. Kung AL, Zabludoff SD, France DS, Freedman SJ, Tanner EA, Vieira A, Cornell-Kennon S, Lee J, Wang B, Wang J, Memmert K, Naegeli HU, Petersen F, Eck MJ, Bair KW, Wood AW, Livingston DM. Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway. Cancer Cell. 2004 Jul; 6(1):33-43. PMID: 15261140.
    Citations: 184     Fields:    Translation:HumansAnimalsCells
  94. Jiang J, Paez JG, Lee JC, Bo R, Stone RM, DeAngelo DJ, Galinsky I, Wolpin BM, Jonasova A, Herman P, Fox EA, Boggon TJ, Eck MJ, Weisberg E, Griffin JD, Gilliland DG, Meyerson M, Sellers WR. Identifying and characterizing a novel activating mutation of the FLT3 tyrosine kinase in AML. Blood. 2004 Sep 15; 104(6):1855-8. PMID: 15178581.
    Citations: 31     Fields:    Translation:HumansCells
  95. Dunty JM, Gabarra-Niecko V, King ML, Ceccarelli DF, Eck MJ, Schaller MD. FERM domain interaction promotes FAK signaling. Mol Cell Biol. 2004 Jun; 24(12):5353-68. PMID: 15169899; PMCID: PMC419890.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  96. Paez JG, Jänne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science. 2004 Jun 04; 304(5676):1497-500. PMID: 15118125.
    Citations: 3259     Fields:    Translation:HumansCells
  97. Simarro M, Lanyi A, Howie D, Poy F, Bruggeman J, Choi M, Sumegi J, Eck MJ, Terhorst C. SAP increases FynT kinase activity and is required for phosphorylation of SLAM and Ly9. Int Immunol. 2004 May; 16(5):727-36. PMID: 15096483.
    Citations: 23     Fields:    Translation:AnimalsCells
  98. Xu Y, Moseley JB, Sagot I, Poy F, Pellman D, Goode BL, Eck MJ. Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture. Cell. 2004 Mar 05; 116(5):711-23. PMID: 15006353.
    Citations: 168     Fields:    Translation:Cells
  99. Moseley JB, Sagot I, Manning AL, Xu Y, Eck MJ, Pellman D, Goode BL. A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin. Mol Biol Cell. 2004 Feb; 15(2):896-907. PMID: 14657240; PMCID: PMC329402.
    Citations: 136     Fields:    Translation:AnimalsCells
  100. Towbin H, Bair KW, DeCaprio JA, Eck MJ, Kim S, Kinder FR, Morollo A, Mueller DR, Schindler P, Song HK, van Oostrum J, Versace RW, Voshol H, Wood J, Zabludoff S, Phillips PE. Proteomics-based target identification: bengamides as a new class of methionine aminopeptidase inhibitors. J Biol Chem. 2003 Dec 26; 278(52):52964-71. PMID: 14534293.
    Citations: 40     Fields:    Translation:HumansCells
  101. Engel P, Eck MJ, Terhorst C. The SAP and SLAM families in immune responses and X-linked lymphoproliferative disease. Nat Rev Immunol. 2003 Oct; 3(10):813-21. PMID: 14523387.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  102. Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science. 2003 Sep 19; 301(5640):1725-8. PMID: 14500983.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  103. Song HK, Eck MJ. Structural basis of degradation signal recognition by SspB, a specificity-enhancing factor for the ClpXP proteolytic machine. Mol Cell. 2003 Jul; 12(1):75-86. PMID: 12887894.
    Citations: 26     Fields:    Translation:Cells
  104. Freedman SJ, Sun ZY, Kung AL, France DS, Wagner G, Eck MJ. Structural basis for negative regulation of hypoxia-inducible factor-1alpha by CITED2. Nat Struct Biol. 2003 Jul; 10(7):504-12. PMID: 12778114.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  105. Wang JH, Eck MJ. Assembling atomic resolution views of the immunological synapse. Curr Opin Immunol. 2003 Jun; 15(3):286-93. PMID: 12787753.
    Citations:    Fields:    Translation:AnimalsCells
  106. Stolt PC, Jeon H, Song HK, Herz J, Eck MJ, Blacklow SC. Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure. 2003 May; 11(5):569-79. PMID: 12737822.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  107. Chan B, Lanyi A, Song HK, Griesbach J, Simarro-Grande M, Poy F, Howie D, Sumegi J, Terhorst C, Eck MJ. SAP couples Fyn to SLAM immune receptors. Nat Cell Biol. 2003 Feb; 5(2):155-60. PMID: 12545174.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  108. Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ. Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. J Biol Chem. 2003 Apr 11; 278(15):13462-7. PMID: 12556468.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  109. Summy JM, Sudol M, Eck MJ, Monteiro AN, Gatesman A, Flynn DC. Specificity in signaling by c-Yes. Front Biosci. 2003 Jan 01; 8:s185-205. PMID: 12456296.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  110. Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ. Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha. Proc Natl Acad Sci U S A. 2002 Apr 16; 99(8):5367-72. PMID: 11959990; PMCID: PMC122775.
    Citations: 174     Fields:    Translation:HumansAnimalsCells
  111. Witucki LA, Huang X, Shah K, Liu Y, Kyin S, Eck MJ, Shokat KM. Mutant tyrosine kinases with unnatural nucleotide specificity retain the structure and phospho-acceptor specificity of the wild-type enzyme. Chem Biol. 2002 Jan; 9(1):25-33. PMID: 11841936.
    Citations: 20     Fields:    Translation:Cells
  112. Poy F, Lepourcelet M, Shivdasani RA, Eck MJ. Structure of a human Tcf4-beta-catenin complex. Nat Struct Biol. 2001 Dec; 8(12):1053-7. PMID: 11713476.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  113. Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. EMBO J. 2001 Nov 01; 20(21):5840-52. PMID: 11689425; PMCID: PMC125701.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  114. Curat CA, Eck M, Dervillez X, Vogel WF. Mapping of epitopes in discoidin domain receptor 1 critical for collagen binding. J Biol Chem. 2001 Dec 07; 276(49):45952-8. PMID: 11598108.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  115. Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C. Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients. J Biol Chem. 2001 Sep 28; 276(39):36809-16. PMID: 11477068.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  116. Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nat Struct Biol. 2001 Jun; 8(6):499-504. PMID: 11373616.
    Citations: 77     Fields:    Translation:HumansCells
  117. Morollo AA, Eck MJ. Structure of the cooperative allosteric anthranilate synthase from Salmonella typhimurium. Nat Struct Biol. 2001 Mar; 8(3):243-7. PMID: 11224570.
    Citations: 26     Fields:    Translation:Cells
  118. Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC. Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell. 2000 Aug 04; 102(3):387-97. PMID: 10975528.
    Citations: 201     Fields:    Translation:Cells
  119. Huang X, Poy F, Zhang R, Joachimiak A, Sudol M, Eck MJ. Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan. Nat Struct Biol. 2000 Aug; 7(8):634-8. PMID: 10932245.
    Citations: 82     Fields:    Translation:HumansCells
  120. Sawasdikosol S, Pratt JC, Meng W, Eck MJ, Burakoff SJ. Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase. Biochim Biophys Acta. 2000 Jul 31; 1471(1):M1-M12. PMID: 11004605.
    Citations: 6     Fields:    Translation:AnimalsCells
  121. Poy F, Yaffe MB, Sayos J, Saxena K, Morra M, Sumegi J, Cantley LC, Terhorst C, Eck MJ. Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell. 1999 Oct; 4(4):555-61. PMID: 10549287.
    Citations: 62     Fields:    Translation:HumansCells
  122. Lupher ML, Rao N, Eck MJ, Band H. The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction. Immunol Today. 1999 Aug; 20(8):375-82. PMID: 10431158.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  123. Dhe-Paganon S, Ottinger EA, Nolte RT, Eck MJ, Shoelson SE. Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1. Proc Natl Acad Sci U S A. 1999 Jul 20; 96(15):8378-83. PMID: 10411883; PMCID: PMC17524.
    Citations: 24     Fields:    Translation:HumansCells
  124. Xu W, Doshi A, Lei M, Eck MJ, Harrison SC. Crystal structures of c-Src reveal features of its autoinhibitory mechanism. Mol Cell. 1999 May; 3(5):629-38. PMID: 10360179.
    Citations: 316     Fields:    Translation:HumansCells
  125. Meng W, Sawasdikosol S, Burakoff SJ, Eck MJ. Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase. Nature. 1999 Mar 04; 398(6722):84-90. PMID: 10078535.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  126. Schaper F, Gendo C, Eck M, Schmitz J, Grimm C, Anhuf D, Kerr IM, Heinrich PC. Activation of the protein tyrosine phosphatase SHP2 via the interleukin-6 signal transducing receptor protein gp130 requires tyrosine kinase Jak1 and limits acute-phase protein expression. Biochem J. 1998 Nov 01; 335 ( Pt 3):557-65. PMID: 9794795; PMCID: PMC1219816.
    Citations: 50     Fields:    Translation:HumansCells
  127. Huse M, Eck MJ, Harrison SC. A Zn2+ ion links the cytoplasmic tail of CD4 and the N-terminal region of Lck. J Biol Chem. 1998 Jul 24; 273(30):18729-33. PMID: 9668045.
    Citations: 23     Fields:    Translation:Cells
  128. Hof P, Pluskey S, Dhe-Paganon S, Eck MJ, Shoelson SE. Crystal structure of the tyrosine phosphatase SHP-2. Cell. 1998 Feb 20; 92(4):441-50. PMID: 9491886.
    Citations: 264     Fields:    Translation:HumansCells
  129. Sondhi D, Xu W, Songyang Z, Eck MJ, Cole PA. Peptide and protein phosphorylation by protein tyrosine kinase Csk: insights into specificity and mechanism. Biochemistry. 1998 Jan 06; 37(1):165-72. PMID: 9425036.
    Citations: 27     Fields:    Translation:HumansCells
  130. Kuipers F, Jong MC, Lin Y, Eck M, Havinga R, Bloks V, Verkade HJ, Hofker MH, Moshage H, Berkel TJ, Vonk RJ, Havekes LM. Impaired secretion of very low density lipoprotein-triglycerides by apolipoprotein E- deficient mouse hepatocytes. J Clin Invest. 1997 Dec 01; 100(11):2915-22. PMID: 9389759; PMCID: PMC508499.
    Citations: 38     Fields:    Translation:AnimalsCells
  131. Xu W, Harrison SC, Eck MJ. Three-dimensional structure of the tyrosine kinase c-Src. Nature. 1997 Feb 13; 385(6617):595-602. PMID: 9024657.
    Citations: 392     Fields:    Translation:HumansCells
  132. Saxena K, Gaitatzes C, Walsh MT, Eck M, Neer EJ, Smith TF. Analysis of the physical properties and molecular modeling of Sec13: A WD repeat protein involved in vesicular traffic. Biochemistry. 1996 Dec 03; 35(48):15215-21. PMID: 8952469.
    Citations: 11     Fields:    Translation:Cells
  133. Weissenhorn W, Eck MJ, Harrison SC, Wiley DC. Phosphorylated T cell receptor zeta-chain and ZAP70 tandem SH2 domains form a 1:3 complex in vitro. Eur J Biochem. 1996 Jun 01; 238(2):440-5. PMID: 8681956.
    Citations: 8     Fields:    Translation:Cells
  134. Eck MJ, Dhe-Paganon S, Trüb T, Nolte RT, Shoelson SE. Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor. Cell. 1996 May 31; 85(5):695-705. PMID: 8646778.
    Citations: 72     Fields:    Translation:HumansCells
  135. Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC. Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes. Nat Struct Biol. 1996 Apr; 3(4):364-74. PMID: 8599763.
    Citations: 54     Fields:    Translation:HumansCells
  136. Eck MJ, Pluskey S, Trüb T, Harrison SC, Shoelson SE. Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. Nature. 1996 Jan 18; 379(6562):277-80. PMID: 8538796.
    Citations: 53     Fields:    Translation:HumansCells
  137. Eck MJ. A new flavor in phosphotyrosine recognition. Structure. 1995 May 15; 3(5):421-4. PMID: 7545066.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  138. Mayer BJ, Eck MJ. SH3 domains. Minding your p's and q's. Curr Biol. 1995 Apr 01; 5(4):364-7. PMID: 7542990.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  139. Songyang Z, Carraway KL, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C, et al. Catalytic specificity of protein-tyrosine kinases is critical for selective signalling. Nature. 1995 Feb 09; 373(6514):536-9. PMID: 7845468.
    Citations: 255     Fields:    Translation:HumansAnimalsCells
  140. Rodseth LE, Brandhuber B, Devine TQ, Eck MJ, Hale K, Naismith JH, Sprang SR. Two crystal forms of the extracellular domain of type I tumor necrosis factor receptor. J Mol Biol. 1994 Jun 03; 239(2):332-5. PMID: 8196061.
    Citations: 3     Fields:    Translation:HumansCells
  141. Leppik RA, Miller RC, Eck M, Paquet JL. Role of acidic amino acids in the allosteric modulation by gallamine of antagonist binding at the m2 muscarinic acetylcholine receptor. Mol Pharmacol. 1994 May; 45(5):983-90. PMID: 8190113.
    Citations: 23     Fields:    Translation:AnimalsCells
  142. Eck MJ, Atwell SK, Shoelson SE, Harrison SC. Structure of the regulatory domains of the Src-family tyrosine kinase Lck. Nature. 1994 Apr 21; 368(6473):764-9. PMID: 7512222.
    Citations: 58     Fields:    Translation:Cells
  143. Eck MJ, Shoelson SE, Harrison SC. Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature. 1993 Mar 04; 362(6415):87-91. PMID: 7680435.
    Citations: 111     Fields:    Translation:Cells
  144. Eck MJ, Ultsch M, Rinderknecht E, de Vos AM, Sprang SR. The structure of human lymphotoxin (tumor necrosis factor-beta) at 1.9-A resolution. J Biol Chem. 1992 Feb 05; 267(4):2119-22. PMID: 1733919.
    Citations: 21     Fields:    Translation:AnimalsCells
  145. Eck MJ, Sprang SR. The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding. J Biol Chem. 1989 Oct 15; 264(29):17595-605. PMID: 2551905.
    Citations: 114     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.