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Jodie L Babitt, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK087727 (BABITT, JODIE L) Jul 1, 2010 - Jul 31, 2020
    Regulation of Iron Homeostasis by BMP Signaling
    Role: Principal Investigator
  2. K08DK075846 (BABITT, JODIE L) Jul 1, 2006 - Jan 31, 2012
    BMP Signaling and Iron Metabolism
    Role: Principal Investigator
  3. F32DK068997 (BABITT, JODIE L) Jul 1, 2004 - Jun 30, 2006
    BMP Signaling in Kidney Epithelial Cells
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang CY, Babitt JL. Liver iron sensing and body iron homeostasis. Blood. 2018 Nov 06. PMID: 30401708.
    View in: PubMed
  2. He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M. Large G protein a-subunit XLas limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9559-E9568. PMID: 29078380.
    View in: PubMed
  3. Canali S, Wang CY, Zumbrennen-Bullough KB, Bayer A, Babitt JL. Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6. Am J Hematol. 2017 Nov; 92(11):1204-1213. PMID: 28815688.
    View in: PubMed
  4. Wang CY, Core AB, Canali S, Zumbrennen-Bullough KB, Ozer S, Umans L, Zwijsen A, Babitt JL. Smad1/5 is required for erythropoietin-mediated suppression of hepcidin in mice. Blood. 2017 07 06; 130(1):73-83. PMID: 28438754.
    View in: PubMed
  5. Dev S, Babitt JL. Overview of iron metabolism in health and disease. Hemodial Int. 2017 06; 21 Suppl 1:S6-S20. PMID: 28296010.
    View in: PubMed
  6. Canali S, Zumbrennen-Bullough KB, Core AB, Wang CY, Nairz M, Bouley R, Swirski FK, Babitt JL. Endothelial cells produce bone morphogenetic protein 6 required for iron homeostasis in mice. Blood. 2017 01 26; 129(4):405-414. PMID: 27864295.
    View in: PubMed
  7. Sise ME, Wisocky J, Rosales IA, Chute D, Holmes JA, Corapi KM, Babitt JL, Tangren JS, Hashemi N, Lundquist AL, Williams WW, Mount DB, Andersson KL, Rennke HG, Smith RN, Colvin R, Thadhani RI, Chung RT. Lupus-like Immune Complex-mediated Glomerulonephritis in Patients with Hepatitis C Virus Infection Treated with Oral, Interferon-free, Direct-acting Antiviral Therapy. Kidney Int Rep. 2016 Sep; 1(3):135-143. PMID: 27990496.
    View in: PubMed
  8. David V, Francis C, Babitt JL. Ironing out the cross talk between FGF23 and inflammation. Am J Physiol Renal Physiol. 2017 01 01; 312(1):F1-F8. PMID: 27582104.
    View in: PubMed
  9. Canali S, Vecchi C, Garuti C, Montosi G, Babitt JL, Pietrangelo A. The SMAD Pathway Is Required for Hepcidin Response During Endoplasmic Reticulum Stress. Endocrinology. 2016 Oct; 157(10):3935-3945. PMID: 27483343.
    View in: PubMed
  10. Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat Med. 2016 08; 22(8):945-51. PMID: 27428900; PMCID: PMC4957133 [Available on 01/18/17].
  11. Wang CY, Babitt JL. Hepcidin regulation in the anemia of inflammation. Curr Opin Hematol. 2016 May; 23(3):189-97. PMID: 26886082; PMCID: PMC4993159 [Available on 05/01/17].
  12. Canali S, Core AB, Zumbrennen-Bullough KB, Merkulova M, Wang CY, Schneyer AL, Pietrangelo A, Babitt JL. Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice. Endocrinology. 2016 Mar; 157(3):1146-62. PMID: 26735394; PMCID: PMC4769363 [Available on 03/01/17].
  13. David V, Martin A, Isakova T, Spaulding C, Qi L, Ramirez V, Zumbrennen-Bullough KB, Sun CC, Lin HY, Babitt JL, Wolf M. Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. Kidney Int. 2016 Jan; 89(1):135-46. PMID: 26535997; PMCID: PMC4854810.
  14. Samir AE, Allegretti AS, Zhu Q, Dhyani M, Anvari A, Sullivan DA, Trottier CA, Dougherty S, Williams WW, Babitt JL, Wenger J, Thadhani RI, Lin HY. Shear wave elastography in chronic kidney disease: a pilot experience in native kidneys. BMC Nephrol. 2015 Jul 31; 16:119. PMID: 26227484; PMCID: PMC4521488.
  15. Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res. 2015 Jun 01; 75(11):2254-63. PMID: 25858146; PMCID: PMC4454355.
  16. Pauk M, Grgurevic L, Brkljacic J, Kufner V, Bordukalo-Niksic T, Grabusic K, Razdorov G, Rogic D, Zuvic M, Oppermann H, Babitt JL, Lin HY, Volarevic S, Vukicevic S. Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice. Int Orthop. 2015 Jan; 39(1):161-72. PMID: 25300398.
    View in: PubMed
  17. Zumbrennen-Bullough KB, Wu Q, Core AB, Canali S, Chen W, Theurl I, Meynard D, Babitt JL. MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription. J Biol Chem. 2014 Aug 22; 289(34):23796-808. PMID: 25002578; PMCID: PMC4156078.
  18. Core AB, Canali S, Babitt JL. Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis. Front Pharmacol. 2014; 5:104. PMID: 24860505; PMCID: PMC4026703.
  19. Babitt JL, Lin HY. BuMPing iron with modified heparins. Blood. 2014 Mar 06; 123(10):1440-1. PMID: 24627550; PMCID: PMC3945857.
  20. Meynard D, Sun CC, Wu Q, Chen W, Chen S, Nelson CN, Waters MJ, Babitt JL, Lin HY. Inflammation regulates TMPRSS6 expression via STAT5. PLoS One. 2013; 8(12):e82127. PMID: 24376517; PMCID: PMC3871639.
  21. Zumbrennen-Bullough K, Babitt JL. The iron cycle in chronic kidney disease (CKD): from genetics and experimental models to CKD patients. Nephrol Dial Transplant. 2014 Feb; 29(2):263-73. PMID: 24235084; PMCID: PMC3910345.
  22. Meynard D, Babitt JL, Lin HY. The liver: conductor of systemic iron balance. Blood. 2014 Jan 09; 123(2):168-76. PMID: 24200681; PMCID: PMC3888285.
  23. Sun CC, Vaja V, Chen S, Theurl I, Stepanek A, Brown DE, Cappellini MD, Weiss G, Hong CC, Lin HY, Babitt JL. A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats. Nephrol Dial Transplant. 2013 Jul; 28(7):1733-43. PMID: 23345622; PMCID: PMC3707526.
  24. Bouley R, Nunes P, Andriopoulos B, McLaughlin M, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D. Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F553-64. PMID: 23235478; PMCID: PMC3602717.
  25. Wu Q, Sun CC, Lin HY, Babitt JL. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS One. 2012; 7(9):e46307. PMID: 23029472; PMCID: PMC3459908.
  26. Gutiérrez OM, Sun CC, Chen W, Babitt JL, Lin HY. Statement of concern about a commercial assay used to measure soluble hemojuvelin in humans. Am J Nephrol. 2012; 36(4):332-3; author reply 333. PMID: 23006450.
    View in: PubMed
  27. Wu X, Yung LM, Cheng WH, Yu PB, Babitt JL, Lin HY, Xia Y. Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent. PLoS One. 2012; 7(9):e44622. PMID: 23028567; PMCID: PMC3441567.
  28. Babitt JL, Lin HY. Mechanisms of anemia in CKD. J Am Soc Nephrol. 2012 Oct; 23(10):1631-4. PMID: 22935483; PMCID: PMC3458456.
  29. Chen W, Sun CC, Chen S, Meynard D, Babitt JL, Lin HY. A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum. Haematologica. 2013 Feb; 98(2):296-304. PMID: 22875629; PMCID: PMC3561439.
  30. Sun CC, Vaja V, Babitt JL, Lin HY. Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation. Am J Hematol. 2012 Apr; 87(4):392-400. PMID: 22290531; PMCID: PMC3653431.
  31. Babitt JL, Lin HY. The molecular pathogenesis of hereditary hemochromatosis. Semin Liver Dis. 2011 Aug; 31(3):280-92. PMID: 21901658.
    View in: PubMed
  32. Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, Feng Q, Migas MC, Britton RS, Babitt JL, Fleming RE. Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe. Gastroenterology. 2011 Nov; 141(5):1907-14. PMID: 21745449; PMCID: PMC3634343.
  33. Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood. 2011 Nov 03; 118(18):4977-84. PMID: 21730356; PMCID: PMC3208302.
  34. Corradini E, Meynard D, Wu Q, Chen S, Ventura P, Pietrangelo A, Babitt JL. Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice. Hepatology. 2011 Jul; 54(1):273-84. PMID: 21488083; PMCID: PMC3277401.
  35. Meynard D, Vaja V, Sun CC, Corradini E, Chen S, López-Otín C, Grgurevic L, Hong CC, Stirnberg M, Gütschow M, Vukicevic S, Babitt JL, Lin HY. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood. 2011 Jul 21; 118(3):747-56. PMID: 21622652; PMCID: PMC3142910.
  36. Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ. The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflamm Bowel Dis. 2012 Jan; 18(1):112-9. PMID: 21351217.
    View in: PubMed
  37. Gibert Y, Lattanzi VJ, Zhen AW, Vedder L, Brunet F, Faasse SA, Babitt JL, Lin HY, Hammerschmidt M, Fraenkel PG. BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin. PLoS One. 2011 Jan 21; 6(1):e14553. PMID: 21283739; PMCID: PMC3024971.
  38. Bolondi G, Garuti C, Corradini E, Zoller H, Vogel W, Finkenstedt A, Babitt JL, Lin HY, Pietrangelo A. Altered hepatic BMP signaling pathway in human HFE hemochromatosis. Blood Cells Mol Dis. 2010 Dec 15; 45(4):308-12. PMID: 20863724; PMCID: PMC3295241.
  39. Corradini E, Schmidt PJ, Meynard D, Garuti C, Montosi G, Chen S, Vukicevic S, Pietrangelo A, Lin HY, Babitt JL. BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology. 2010 Nov; 139(5):1721-9. PMID: 20682319; PMCID: PMC3295242.
  40. Babitt JL, Lin HY. Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. Am J Kidney Dis. 2010 Apr; 55(4):726-41. PMID: 20189278; PMCID: PMC2905036.
  41. Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol. 2010 Apr; 21(4):666-77. PMID: 20167703; PMCID: PMC2844302.
  42. Corradini E, Babitt JL, Lin HY. The RGM/DRAGON family of BMP co-receptors. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):389-98. PMID: 19897400; PMCID: PMC3715994.
  43. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest. 2009 Nov; 119(11):3322-8. PMID: 19809161.
    View in: PubMed
  44. Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B, Lin HY, Pietrangelo A, Babitt JL. Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology. 2009 Oct; 137(4):1489-97. PMID: 19591830; PMCID: PMC2757523.
  45. Andriopoulos B, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009 Apr; 41(4):482-7. PMID: 19252486; PMCID: PMC2810136.
  46. Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008 May 15; 111(10):5195-204. PMID: 18326817; PMCID: PMC2384142.
  47. Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan; 4(1):33-41. PMID: 18026094; PMCID: PMC2727650.
  48. Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest. 2007 Jul; 117(7):1933-9. PMID: 17607365; PMCID: PMC1904317.
  49. Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006 May; 38(5):531-9. PMID: 16604073.
    View in: PubMed
  50. Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem. 2005 Aug 19; 280(33):29820-7. PMID: 15975920.
    View in: PubMed
  51. del Re E, Babitt JL, Pirani A, Schneyer AL, Lin HY. In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2. J Biol Chem. 2004 May 21; 279(21):22765-72. PMID: 14996829.
    View in: PubMed
  52. Gu X, Trigatti B, Xu S, Acton S, Babitt J, Krieger M. The efficient cellular uptake of high density lipoprotein lipids via scavenger receptor class B type I requires not only receptor-mediated surface binding but also receptor-specific lipid transfer mediated by its extracellular domain. J Biol Chem. 1998 Oct 09; 273(41):26338-48. PMID: 9756864.
    View in: PubMed
  53. Rigotti A, Trigatti B, Babitt J, Penman M, Xu S, Krieger M. Scavenger receptor BI--a cell surface receptor for high density lipoprotein. Curr Opin Lipidol. 1997 Jun; 8(3):181-8. PMID: 9211067.
    View in: PubMed
  54. Babitt J, Trigatti B, Rigotti A, Smart EJ, Anderson RG, Xu S, Krieger M. Murine SR-BI, a high density lipoprotein receptor that mediates selective lipid uptake, is N-glycosylated and fatty acylated and colocalizes with plasma membrane caveolae. J Biol Chem. 1997 May 16; 272(20):13242-9. PMID: 9148942.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.