Harvard Catalyst Profiles

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John Edgar Baker, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI080363 (BAKER, JOHN E) Sep 22, 2009 - Aug 31, 2012
    Radiation injury to the heart
    Role: Principal Investigator
  2. P50HL065203 (GUTTERMAN, DAVID D.) Sep 30, 2000 - Jul 31, 2005
    Role: Co-Principal Investigator
  3. R01HL066334 (BAKER, JOHN E) Sep 30, 2000 - Aug 31, 2004
    Role: Principal Investigator
  4. R01HL054075 (BAKER, JOHN E) Apr 1, 1997 - Nov 30, 2006
    Role: Principal Investigator
  5. R29HL043030 (BAKER, JOHN E) Aug 1, 1989 - Jul 31, 1995
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lenarczyk M, Kronenberg A, Mäder M, North PE, Komorowski R, Cheng Q, Little MP, Chiang IH, LaTessa C, Jardine J, Baker JE. Age at Exposure to Radiation Determines Severity of Renal and Cardiac Disease in Rats. Radiat Res. 2019 07; 192(1):63-74. PMID: 31095446.
  2. Malik M, Suboc TM, Tyagi S, Salzman N, Wang J, Ying R, Tanner MJ, Kakarla M, Baker JE, Widlansky ME. Lactobacillus plantarum 299v Supplementation Improves Vascular Endothelial Function and Reduces Inflammatory Biomarkers in Men With Stable Coronary Artery Disease. Circ Res. 2018 10 12; 123(9):1091-1102. PMID: 30355158.
    Citations:    Fields:    
  3. Lam V, Su J, Hsu A, Gross GJ, Salzman NH, Baker JE. Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats. PLoS One. 2016; 11(8):e0160840. PMID: 27505423.
    Citations: 2     Fields:    Translation:Animals
  4. Rentea RM, Lam V, Biesterveld B, Fredrich KM, Callison J, Fish BL, Baker JE, Komorowski R, Gourlay DM, Otterson MF. Radiation-induced changes in intestinal and tissue-nonspecific alkaline phosphatase: implications for recovery after radiation therapy. Am J Surg. 2016 Oct; 212(4):602-608. PMID: 27501776.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Lenarczyk M, Su J, Haworth ST, Komorowski R, Fish BL, Migrino RQ, Harmann L, Hopewell JW, Kronenberg A, Patel S, Moulder JE, Baker JE. Simvastatin mitigates increases in risk factors for and the occurrence of cardiac disease following 10 Gy total body irradiation. Pharmacol Res Perspect. 2015 Jun; 3(3):e00145. PMID: 26171225.
    Citations: 3     Fields:    
  6. Baker JE, Su J, Koprowski S, Dhanasekaran A, Aufderheide TP, Gross GJ. Thrombopoietin receptor agonists protect human cardiac myocytes from injury by activation of cell survival pathways. J Pharmacol Exp Ther. 2015 Mar; 352(3):429-37. PMID: 25512369.
    Citations: 2     Fields:    Translation:HumansCells
  7. Parvin A, Pranap R, Shalini U, Devendran A, Baker JE, Dhanasekaran A. Erythropoietin protects cardiomyocytes from cell death during hypoxia/reperfusion injury through activation of survival signaling pathways. PLoS One. 2014; 9(9):e107453. PMID: 25237819.
    Citations: 8     Fields:    Translation:AnimalsCells
  8. Quirk BJ, Sonowal P, Jazayeri MA, Baker JE, Whelan HT. Cardioprotection from ischemia-reperfusion injury by near-infrared light in rats. Photomed Laser Surg. 2014 Sep; 32(9):505-11. PMID: 25093393.
    Citations: 1     Fields:    Translation:Animals
  9. Sharma A, Fish BL, Moulder JE, Medhora M, Baker JE, Mader M, Cohen EP. Safety and blood sample volume and quality of a refined retro-orbital bleeding technique in rats using a lateral approach. Lab Anim (NY). 2014 Feb; 43(2):63-6. PMID: 24451361.
    Citations: 9     Fields:    Translation:Animals
  10. Lenarczyk M, Lam V, Jensen E, Fish BL, Su J, Koprowski S, Komorowski RA, Harmann L, Migrino RQ, Li XA, Hopewell JW, Moulder JE, Baker JE. Cardiac injury after 10 gy total body irradiation: indirect role of effects on abdominal organs. Radiat Res. 2013 Sep; 180(3):247-58. PMID: 23919311.
    Citations: 17     Fields:    Translation:AnimalsCellsPHPublic Health
  11. Ziarek JJ, Veldkamp CT, Zhang F, Murray NJ, Kartz GA, Liang X, Su J, Baker JE, Linhardt RJ, Volkman BF. Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus. J Biol Chem. 2013 Jan 04; 288(1):737-46. PMID: 23148226.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  12. Lam V, Moulder JE, Salzman NH, Dubinsky EA, Andersen GL, Baker JE. Intestinal microbiota as novel biomarkers of prior radiation exposure. Radiat Res. 2012 May; 177(5):573-83. PMID: 22439602.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  13. Lam V, Su J, Koprowski S, Hsu A, Tweddell JS, Rafiee P, Gross GJ, Salzman NH, Baker JE. Intestinal microbiota determine severity of myocardial infarction in rats. FASEB J. 2012 Apr; 26(4):1727-35. PMID: 22247331.
    Citations: 40     Fields:    Translation:HumansAnimals
  14. Gross GJ, Baker JE, Moore J, Falck JR, Nithipatikom K. Abdominal surgical incision induces remote preconditioning of trauma (RPCT) via activation of bradykinin receptors (BK2R) and the cytochrome P450 epoxygenase pathway in canine hearts. Cardiovasc Drugs Ther. 2011 Dec; 25(6):517-22. PMID: 21786213.
    Citations: 21     Fields:    Translation:Animals
  15. Baker JE, Moulder JE, Hopewell JW. Radiation as a risk factor for cardiovascular disease. Antioxid Redox Signal. 2011 Oct 01; 15(7):1945-56. PMID: 21091078.
    Citations: 20     Fields:    Translation:HumansAnimalsPHPublic Health
  16. Gross GJ, Baker JE, Hsu A, Wu HE, Falck JR, Nithipatikom K. Evidence for a role of opioids in epoxyeicosatrienoic acid-induced cardioprotection in rat hearts. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H2201-7. PMID: 20400686.
    Citations: 16     Fields:    Translation:Animals
  17. Strande JL, Routhu KV, Hsu A, Nicolosi AC, Baker JE. Gadolinium decreases inflammation related to myocardial ischemia and reperfusion injury. J Inflamm (Lond). 2009 Dec 10; 6:34. PMID: 20003243.
    Citations: 4     
  18. Baker JE, Fish BL, Su J, Haworth ST, Strande JL, Komorowski RA, Migrino RQ, Doppalapudi A, Harmann L, Allen Li X, Hopewell JW, Moulder JE. 10 Gy total body irradiation increases risk of coronary sclerosis, degeneration of heart structure and function in a rat model. Int J Radiat Biol. 2009 Dec; 85(12):1089-100. PMID: 19995235.
    Citations: 28     Fields:    Translation:AnimalsCells
  19. Veldkamp CT, Ziarek JJ, Su J, Basnet H, Lennertz R, Weiner JJ, Peterson FC, Baker JE, Volkman BF. Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12. Protein Sci. 2009 Jul; 18(7):1359-69. PMID: 19551879.
    Citations: 34     Fields:    Translation:AnimalsCells
  20. Strande JL, Widlansky ME, Tsopanoglou NE, Su J, Wang J, Hsu A, Routhu KV, Baker JE. Parstatin: a cryptic peptide involved in cardioprotection after ischaemia and reperfusion injury. Cardiovasc Res. 2009 Jul 15; 83(2):325-34. PMID: 19380418.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. Aggarwal NT, Pfister SL, Gauthier KM, Chawengsub Y, Baker JE, Campbell WB. Chronic hypoxia enhances 15-lipoxygenase-mediated vasorelaxation in rabbit arteries. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H678-88. PMID: 19112096.
    Citations: 6     Fields:    Translation:Animals
  22. Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE. Inhibiting protease-activated receptor 4 limits myocardial ischemia/reperfusion injury in rat hearts by unmasking adenosine signaling. J Pharmacol Exp Ther. 2008 Mar; 324(3):1045-54. PMID: 18055876.
    Citations: 22     Fields:    Translation:AnimalsCells
  23. Nicolosi AC, Strande JL, Hsu A, Fu X, Su J, Gross GJ, Baker JE. Gadolinium limits myocardial infarction in the rat: dose-response, temporal relations and mechanisms. J Mol Cell Cardiol. 2008 Feb; 44(2):345-51. PMID: 18083188.
    Citations: 4     Fields:    Translation:Animals
  24. Shi Y, Jiang MT, Su J, Hutchins W, Konorev E, Baker JE. Mitochondrial big conductance KCa channel and cardioprotection in infant rabbit heart. J Cardiovasc Pharmacol. 2007 Nov; 50(5):497-502. PMID: 18030058.
    Citations: 7     Fields:    Translation:AnimalsCells
  25. Baker JE, Su J, Hsu A, Shi Y, Zhao M, Strande JL, Fu X, Xu H, Eis A, Komorowski R, Jensen ES, Tweddell JS, Rafiee P, Gross GJ. Human thrombopoietin reduces myocardial infarct size, apoptosis, and stunning following ischaemia/reperfusion in rats. Cardiovasc Res. 2008 Jan; 77(1):44-53. PMID: 18006466.
    Citations: 11     Fields:    Translation:HumansAnimals
  26. Baker JE, Su J, Fu X, Hsu A, Gross GJ, Tweddell JS, Hogg N. Nitrite confers protection against myocardial infarction: role of xanthine oxidoreductase, NADPH oxidase and K(ATP) channels. J Mol Cell Cardiol. 2007 Oct; 43(4):437-44. PMID: 17765919.
    Citations: 49     Fields:    Translation:Animals
  27. Baker JE, Kozik D, Hsu AK, Fu X, Tweddell JS, Gross GJ. Darbepoetin alfa protects the rat heart against infarction: dose-response, phase of action, and mechanisms. J Cardiovasc Pharmacol. 2007 Jun; 49(6):337-45. PMID: 17577097.
    Citations: 14     Fields:    Translation:AnimalsCells
  28. Strande JL, Hsu A, Su J, Fu X, Gross GJ, Baker JE. SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Basic Res Cardiol. 2007 Jul; 102(4):350-8. PMID: 17468933.
    Citations: 36     Fields:    Translation:AnimalsCells
  29. Cabigas BP, Su J, Hutchins W, Shi Y, Schaefer RB, Recinos RF, Nilakantan V, Kindwall E, Niezgoda JA, Baker JE. Hyperoxic and hyperbaric-induced cardioprotection: role of nitric oxide synthase 3. Cardiovasc Res. 2006 Oct 01; 72(1):143-51. PMID: 16930572.
    Citations: 21     Fields:    Translation:AnimalsCells
  30. Nilakantan V, Zhou X, Hilton G, Shi Y, Baker JE, Khanna AK, Pieper GM. Antagonizing reactive oxygen by treatment with a manganese (III) metalloporphyrin-based superoxide dismutase mimetic in cardiac transplants. J Thorac Cardiovasc Surg. 2006 Apr; 131(4):898-906. PMID: 16580450.
    Citations: 7     Fields:    Translation:Animals
  31. Kwitek AE, Jacob HJ, Baker JE, Dwinell MR, Forster HV, Greene AS, Kunert MP, Lombard JH, Mattson DL, Pritchard KA, Roman RJ, Tonellato PJ, Cowley AW. BN phenome: detailed characterization of the cardiovascular, renal, and pulmonary systems of the sequenced rat. Physiol Genomics. 2006 Apr 13; 25(2):303-13. PMID: 16478827.
    Citations: 15     Fields:    Translation:Animals
  32. Shi Y, Hutchins W, Ogawa H, Chang CC, Pritchard KA, Zhang C, Khampang P, Lazar J, Jacob HJ, Rafiee P, Baker JE. Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. J Mol Cell Cardiol. 2005 Apr; 38(4):625-35. PMID: 15808839.
    Citations: 14     Fields:    Translation:Animals
  33. Baker JE. Erythropoietin mimics ischemic preconditioning. Vascul Pharmacol. 2005 Apr-May; 42(5-6):233-41. PMID: 15922256.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  34. Rafiee P, Shi Y, Su J, Pritchard KA, Tweddell JS, Baker JE. Erythropoietin protects the infant heart against ischemia-reperfusion injury by triggering multiple signaling pathways. Basic Res Cardiol. 2005 May; 100(3):187-97. PMID: 15611843.
    Citations: 28     Fields:    Translation:AnimalsCells
  35. Shi Y, Hutchins WC, Su J, Siker D, Hogg N, Pritchard KA, Keszler A, Tweddell JS, Baker JE. Delayed cardioprotection with isoflurane: role of reactive oxygen and nitrogen. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H175-84. PMID: 15388508.
    Citations: 8     Fields:    Translation:AnimalsCells
  36. Fitzpatrick CM, Shi Y, Hutchins WC, Su J, Gross GJ, Ostadal B, Tweddell JS, Baker JE. Cardioprotection in chronically hypoxic rabbits persists on exposure to normoxia: role of NOS and KATP channels. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H62-8. PMID: 15319200.
    Citations: 8     Fields:    Translation:Animals
  37. Baker JE. Oxidative stress and adaptation of the infant heart to hypoxia and ischemia. Antioxid Redox Signal. 2004 Apr; 6(2):423-9. PMID: 15025944.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  38. Shi Y, Rafiee P, Su J, Pritchard KA, Tweddell JS, Baker JE. Acute cardioprotective effects of erythropoietin in infant rabbits are mediated by activation of protein kinases and potassium channels. Basic Res Cardiol. 2004 May; 99(3):173-82. PMID: 15088102.
    Citations: 19     Fields:    Translation:AnimalsCells
  39. Baker JE, Nicandri GT, Young DC, Owen JR, Wayne JS. A cadaveric study examining acromioclavicular joint congruity after different methods of coracoclavicular loop repair. J Shoulder Elbow Surg. 2003 Nov-Dec; 12(6):595-8. PMID: 14671525.
    Citations: 14     Fields:    Translation:Humans
  40. Rafiee P, Shi Y, Pritchard KA, Ogawa H, Eis AL, Komorowski RA, Fitzpatrick CM, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Baker JE. Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,. J Biol Chem. 2003 Oct 31; 278(44):43636-44. PMID: 12937165.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  41. Zhu D, Medhora M, Campbell WB, Spitzbarth N, Baker JE, Jacobs ER. Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries. Circ Res. 2003 May 16; 92(9):992-1000. PMID: 12690037.
    Citations: 40     Fields:    Translation:AnimalsCells
  42. Shi Y, Baker JE, Zhang C, Tweddell JS, Su J, Pritchard KA. Chronic hypoxia increases endothelial nitric oxide synthase generation of nitric oxide by increasing heat shock protein 90 association and serine phosphorylation. Circ Res. 2002 Aug 23; 91(4):300-6. PMID: 12193462.
    Citations: 22     Fields:    Translation:AnimalsCells
  43. Rafiee P, Shi Y, Kong X, Pritchard KA, Tweddell JS, Litwin SB, Mussatto K, Jaquiss RD, Su J, Baker JE. Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection. Circulation. 2002 Jul 09; 106(2):239-45. PMID: 12105165.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  44. Tonkovic-Capin M, Gross GJ, Bosnjak ZJ, Tweddell JS, Fitzpatrick CM, Baker JE. Delayed cardioprotection by isoflurane: role of K(ATP) channels. Am J Physiol Heart Circ Physiol. 2002 Jul; 283(1):H61-8. PMID: 12063275.
    Citations: 22     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.