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profileDimitrios Spentzos, M.D.

TitleAssociate Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Es 406
330 Brookline Ave
Boston MA 02215
Phone617/667-1948
Fax617/667-1960
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01CA178908     (SPENTZOS, DIMITRIOS)Sep 15, 2014 - Aug 31, 2019
NIH/NCI
Integrated models for metastatic phenotype and outcome prediction in osteosarcoma
Role: Principal Investigator

K22CA138716     (SPENTZOS, DIMITRIOS)Sep 1, 2010 - Aug 31, 2014
NIH/NCI
Dissecting sarcoma complexity via innovative microRNA and informatics approaches
Role: Principal Investigator
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This researcher has shared information about their research resources
in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
DF/HCC Cancer Proteomics Center - Core services (5) and Instruments (11)

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Chen H, Garbutt CC, Spentzos D, Choy E, Hornicek FJ, Duan Z. Expression and Therapeutic Potential of SOX9 in Chordoma. Clin Cancer Res. 2017 Sep 01; 23(17):5176-5186. PMID: 28606919.
    View in: PubMed
  2. Hill KE, Kelly AD, Kuijjer ML, Barry W, Rattani A, Garbutt CC, Kissick H, Janeway K, Perez-Atayde A, Goldsmith J, Gebhardt MC, Arredouani MS, Cote G, Hornicek F, Choy E, Duan Z, Quackenbush J, Haibe-Kains B, Spentzos D. An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets. J Hematol Oncol. 2017 May 15; 10(1):107. PMID: 28506242.
    View in: PubMed
  3. Osaka E, Kelly AD, Spentzos D, Choy E, Yang X, Shen JK, Yang P, Mankin HJ, Hornicek FJ, Duan Z. MicroRNA-155 expression is independently predictive of outcome in chordoma. Oncotarget. 2015 Apr 20; 6(11):9125-39. PMID: 25823817; PMCID: PMC4496207.
  4. Glass K, Quackenbush J, Spentzos D, Haibe-Kains B, Yuan GC. A network model for angiogenesis in ovarian cancer. BMC Bioinformatics. 2015 Apr 11; 16:115. PMID: 25888305; PMCID: PMC4408593.
  5. Duan Z, Shen J, Yang X, Yang P, Osaka E, Choy E, Cote G, Harmon D, Zhang Y, Nielsen GP, Spentzos D, Mankin H, Hornicek F. Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma. J Orthop Res. 2014 May; 32(5):695-701. PMID: 24501096; PMCID: PMC4049352.
  6. Kelly AD, Hill KE, Correll M, Hu L, Wang YE, Rubio R, Duan S, Quackenbush J, Spentzos D. Next-generation sequencing and microarray-based interrogation of microRNAs from formalin-fixed, paraffin-embedded tissue: preliminary assessment of cross-platform concordance. Genomics. 2013 Jul; 102(1):8-14. PMID: 23562991; PMCID: PMC4116671.
  7. Schwede M, Spentzos D, Bentink S, Hofmann O, Haibe-Kains B, Harrington D, Quackenbush J, Culhane AC. Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis. PLoS One. 2013; 8(3):e57799. PMID: 23536770; PMCID: PMC3594231.
  8. Kelly AD, Haibe-Kains B, Janeway KA, Hill KE, Howe E, Goldsmith J, Kurek K, Perez-Atayde AR, Francoeur N, Fan JB, April C, Schneider H, Gebhardt MC, Culhane A, Quackenbush J, Spentzos D. MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32. Genome Med. 2013; 5(1):2. PMID: 23339462; PMCID: PMC3706900.
  9. Fountzilas E, Kelly AD, Perez-Atayde AR, Goldsmith J, Konstantinopoulos PA, Francoeur N, Correll M, Rubio R, Hu L, Gebhardt MC, Quackenbush J, Spentzos D. A microRNA activity map of human mesenchymal tumors: connections to oncogenic pathways; an integrative transcriptomic study. BMC Genomics. 2012 Jul 23; 13:332. PMID: 22823907; PMCID: PMC3443663.
  10. Fountzilas E, Markou K, Vlachtsis K, Nikolaou A, Arapantoni-Dadioti P, Ntoula E, Tassopoulos G, Bobos M, Konstantinopoulos P, Fountzilas G, Spentzos D. Identification and validation of gene expression models that predict clinical outcome in patients with early-stage laryngeal cancer. Ann Oncol. 2012 Aug; 23(8):2146-53. PMID: 22219018; PMCID: PMC3493135.
  11. Kelly AD, Breitkopf SB, Yuan M, Goldsmith J, Spentzos D, Asara JM. Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: application in sarcoma. PLoS One. 2011; 6(10):e25357. PMID: 21984915; PMCID: PMC3184969.
  12. Konstantinopoulos PA, Spentzos D, Fountzilas E, Francoeur N, Sanisetty S, Grammatikos AP, Hecht JL, Cannistra SA. Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer. Cancer Res. 2011 Aug 01; 71(15):5081-9. PMID: 21676886.
    View in: PubMed
  13. Fountzilas E, Angouridakis N, Karasmanis I, Wirtz RM, Eleftheraki AG, Veltrup E, Markou K, Nikolaou A, Konstantinopoulos P, Kotoula V, Spentzos D, Fountzilas G. Prediction of clinical outcome in patients with primary laryngeal carcinoma using gene expression profiling. J Clin Oncol. 2011 May 20; 29(15_suppl):5505. PMID: 28021461.
    View in: PubMed
  14. Konstantinopoulos PA, Cannistra SA, Fountzilas H, Culhane A, Pillay K, Rueda B, Cramer D, Seiden M, Birrer M, Coukos G, Zhang L, Quackenbush J, Spentzos D. Integrated analysis of multiple microarray datasets identifies a reproducible survival predictor in ovarian cancer. PLoS One. 2011 Mar 29; 6(3):e18202. PMID: 21479231; PMCID: PMC3066217.
  15. Konstantinopoulos PA, Spentzos D, Karlan BY, Taniguchi T, Fountzilas E, Francoeur N, Levine DA, Cannistra SA. Gene expression profile of BRCAness that correlates with responsiveness to chemotherapy and with outcome in patients with epithelial ovarian cancer. J Clin Oncol. 2010 Aug 01; 28(22):3555-61. PMID: 20547991; PMCID: PMC2917311.
  16. Konstantinopoulos PA, Fountzilas E, Goldsmith JD, Bhasin M, Pillay K, Francoeur N, Libermann TA, Gebhardt MC, Spentzos D. Analysis of multiple sarcoma expression datasets: implications for classification, oncogenic pathway activation and chemotherapy resistance. PLoS One. 2010 Apr 01; 5(4):e9747. PMID: 20368975; PMCID: PMC2848563.
  17. Rosenblatt J, Wu Z, Vasir B, Zarwan C, Stone R, Mills H, Friedman T, Konstantinopoulos PA, Spentzos D, Ghebremichael M, Stevenson K, Neuberg D, Levine JD, Joyce R, Tzachanis D, Boussiotis V, Kufe D, Avigan D. Generation of tumor-specific T lymphocytes using dendritic cell/tumor fusions and anti-CD3/CD28. J Immunother. 2010 Feb-Mar; 33(2):155-66. PMID: 20145548; PMCID: PMC2938173.
  18. Burga LN, Tung NM, Troyan SL, Bostina M, Konstantinopoulos PA, Fountzilas H, Spentzos D, Miron A, Yassin YA, Lee BT, Wulf GM. Altered proliferation and differentiation properties of primary mammary epithelial cells from BRCA1 mutation carriers. Cancer Res. 2009 Feb 15; 69(4):1273-8. PMID: 19190334; PMCID: PMC3041511.
  19. Prall WC, Czibere A, Grall F, Spentzos D, Steidl U, Giagounidis AA, Kuendgen A, Otu H, Rong A, Libermann TA, Germing U, Gattermann N, Haas R, Aivado M. Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome. Int J Hematol. 2009 Mar; 89(2):173-87. PMID: 19152102.
    View in: PubMed
  20. Konstantinopoulos PA, Fountzilas E, Pillay K, Zerbini LF, Libermann TA, Cannistra SA, Spentzos D. Carboplatin-induced gene expression changes in vitro are prognostic of survival in epithelial ovarian cancer. BMC Med Genomics. 2008 Nov 28; 1:59. PMID: 19038057; PMCID: PMC2613398.
  21. Konstantinopoulos PA, Spentzos D, Cannistra SA. Gene-expression profiling in epithelial ovarian cancer. Nat Clin Pract Oncol. 2008 Oct; 5(10):577-87. PMID: 18648354.
    View in: PubMed
  22. Tworoger SS, Spentzos D, Grall FT, Liebermann TA, Hankinson SE. Reproducibility of proteomic profiles over 3 years in postmenopausal women not taking postmenopausal hormones. Cancer Epidemiol Biomarkers Prev. 2008 Jun; 17(6):1480-5. PMID: 18559564.
    View in: PubMed
  23. Zinkin NT, Grall F, Bhaskar K, Otu HH, Spentzos D, Kalmowitz B, Wells M, Guerrero M, Asara JM, Libermann TA, Afdhal NH. Serum proteomics and biomarkers in hepatocellular carcinoma and chronic liver disease. Clin Cancer Res. 2008 Jan 15; 14(2):470-7. PMID: 18223221.
    View in: PubMed
  24. Jones J, Otu HH, Grall F, Spentzos D, Can H, Aivado M, Belldegrun AS, Pantuck AJ, Libermann TA. Proteomic identification of interleukin-2 therapy response in metastatic renal cell cancer. J Urol. 2008 Feb; 179(2):730-6. PMID: 18082202; PMCID: PMC3836557.
  25. Spentzos D, Cannistra SA, Grall F, Levine DA, Pillay K, Libermann TA, Mantzoros CS. IGF axis gene expression patterns are prognostic of survival in epithelial ovarian cancer. Endocr Relat Cancer. 2007 Sep; 14(3):781-90. PMID: 17914107.
    View in: PubMed
  26. Prall WC, Czibere A, J├Ąger M, Spentzos D, Libermann TA, Gattermann N, Haas R, Aivado M. Age-related transcription levels of KU70, MGST1 and BIK in CD34+ hematopoietic stem and progenitor cells. Mech Ageing Dev. 2007 Sep; 128(9):503-10. PMID: 17714764.
    View in: PubMed
  27. Otu HH, Can H, Spentzos D, Nelson RG, Hanson RL, Looker HC, Knowler WC, Monroy M, Libermann TA, Karumanchi SA, Thadhani R. Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy. Diabetes Care. 2007 Mar; 30(3):638-43. PMID: 17327333.
    View in: PubMed
  28. Aivado M, Spentzos D, Germing U, Alterovitz G, Meng XY, Grall F, Giagounidis AA, Klement G, Steidl U, Otu HH, Czibere A, Prall WC, Iking-Konert C, Shayne M, Ramoni MF, Gattermann N, Haas R, Mitsiades CS, Fung ET, Libermann TA. Serum proteome profiling detects myelodysplastic syndromes and identifies CXC chemokine ligands 4 and 7 as markers for advanced disease. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1307-12. PMID: 17220270; PMCID: PMC1783137.
  29. Spentzos D, Levine DA, Kolia S, Otu H, Boyd J, Libermann TA, Cannistra SA. Unique gene expression profile based on pathologic response in epithelial ovarian cancer. J Clin Oncol. 2005 Nov 01; 23(31):7911-8. PMID: 16204010.
    View in: PubMed
  30. Jones J, Otu H, Spentzos D, Kolia S, Inan M, Beecken WD, Fellbaum C, Gu X, Joseph M, Pantuck AJ, Jonas D, Libermann TA. Gene signatures of progression and metastasis in renal cell cancer. Clin Cancer Res. 2005 Aug 15; 11(16):5730-9. PMID: 16115910.
    View in: PubMed
  31. Fananapazir N, Li M, Spentzos D, Aliferis CF. Formative evaluation of a prototype system for automated analysis of mass spectrometry data. AMIA Annu Symp Proc. 2005; 241-5. PMID: 16779038; PMCID: PMC1560736.
  32. Aivado M, Spentzos D, Alterovitz G, Otu HH, Grall F, Giagounidis AA, Wells M, Cho JY, Germing U, Czibere A, Prall WC, Porter C, Ramoni MF, Libermann TA. Optimization and evaluation of surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) with reversed-phase protein arrays for protein profiling. Clin Chem Lab Med. 2005; 43(2):133-40. PMID: 15843205.
    View in: PubMed
  33. Spentzos D, Levine DA, Ramoni MF, Joseph M, Gu X, Boyd J, Libermann TA, Cannistra SA. Gene expression signature with independent prognostic significance in epithelial ovarian cancer. J Clin Oncol. 2004 Dec 01; 22(23):4700-10. PMID: 15505275.
    View in: PubMed
  34. Alterovitz G, Aivado M, Spentzos D, Libermann TA, Ramoni M, Kohane IS. Analysis and robot pipelined automation for SELDI-TOF mass spectrometry. Conf Proc IEEE Eng Med Biol Soc. 2004; 4:3068-71. PMID: 17270926.
    View in: PubMed
  35. Spentzos D, Mantzoros C, Regan MM, Morrissey ME, Duggan S, Flickner-Garvey S, McCormick H, DeWolf W, Balk S, Bubley GJ. Minimal effect of a low-fat/high soy diet for asymptomatic, hormonally naive prostate cancer patients. Clin Cancer Res. 2003 Aug 15; 9(9):3282-7. PMID: 12960113.
    View in: PubMed
  36. Georgiadis E, Mantzoros CS, Evagelopoulou C, Spentzos D. Adult height and menarcheal age of young women in Greece. Ann Hum Biol. 1997 Jan-Feb; 24(1):55-9. PMID: 9022906.
    View in: PubMed
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