Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Login and Edit is currently disabled

Dimitrios Spentzos, M.D.

Title
Institution
Department
Address
Phone

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R01CA178908 (SPENTZOS, DIMITRIOS) Sep 15, 2014 - Dec 31, 2019
    NIH
    Integrated models for metastatic phenotype and outcome prediction in osteosarcoma
    Role: Principal Investigator
  2. K22CA138716 (SPENTZOS, DIMITRIOS) Sep 1, 2010 - Aug 31, 2014
    NIH
    Dissecting sarcoma complexity via innovative microRNA and informatics approaches
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 47 total Publications Show all
  1. Lietz CE, Newman ET, Kelly AD, Xiang DH, Zhang Z, Ramavenkat N, Bowers JJ, Lozano-Calderon SA, Ebb DH, Raskin KA, Cote GM, Choy E, Nielsen GP, Vlachos IS, Haibe-Kains B, Spentzos D. A dynamic microRNA profile that tracks a chemotherapy resistance phenotype in osteosarcoma. Implications for novel therapeutics. medRxiv. 2024 Jun 20. PMID: 38946948; PMCID: PMC11213079.
    Citations: Article has an altmetric score of 1
  2. Lozano-Calderón SA, Albergo JI, Groot OQ, Merchan NA, El Abiad JM, Salinas V, Gomez Mier LC, Montoya CS, Ferrone ML, Ready JE, Linares FJ, Levin AS, Peleteiro Pensado M, Pozo Kreilinger JJ, Ruiz IB, Ortiz-Cruz EJ, Gebhardt MC, Cote GM, Choy E, Spentzos D, Hung YP, Deshpande V, Chebib IA, McCulloch RA, Farfalli G, Aponte Tinao L, Morris CD, Petur Nielsen G, Anderson ME, Jeys LM. Complete tumor necrosis after neoadjuvant chemotherapy defines good responders in patients with Ewing sarcoma. Cancer. 2023 01 01; 129(1):60-70. PMID: 36305090.
    Citations: 4 Article has an altmetric score of 17
    Fields: NeoNeoplasmsTranslation:Humans
  3. Wei Y, Qin Q, Yan C, Hayes MN, Garcia SP, Xi H, Do D, Jin AH, Eng TC, McCarthy KM, Adhikari A, Onozato ML, Spentzos D, Neilsen GP, Iafrate AJ, Wexler LH, Pyle AD, Suvà ML, Dela Cruz F, Pinello L, Langenau DM. Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma. Nat Cancer. 2022 08; 3(8):961-975. PMID: 35982179; PMCID: PMC10430812.
    Citations: 22 Article has an altmetric score of 23
    Fields: NeoNeoplasmsTranslation:HumansCells
  4. Möller E, Praz V, Rajendran S, Dong R, Cauderay A, Xing YH, Lee L, Fusco C, Broye LC, Cironi L, Iyer S, Rengarajan S, Awad ME, Naigles B, Letovanec I, Ormas N, Finzi G, La Rosa S, Sessa F, Chebib I, Petur Nielsen G, Digklia A, Spentzos D, Cote GM, Choy E, Aryee M, Stamenkovic I, Boulay G, Rivera MN, Riggi N. EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma. Nat Commun. 2022 04 27; 13(1):2267. PMID: 35477713; PMCID: PMC9046276.
    Citations: 14 Article has an altmetric score of 10
    Fields: BioBiologySciScienceTranslation:HumansCells
  5. Lietz CE, Newman ET, Kelly AD, Xiang DH, Zhang Z, Luscko CA, Lozano-Calderon SA, Ebb DH, Raskin KA, Cote GM, Choy E, Nielsen GP, Haibe-Kains B, Aryee MJ, Spentzos D. Genome-wide DNA methylation patterns reveal clinically relevant predictive and prognostic subtypes in human osteosarcoma. Commun Biol. 2022 03 08; 5(1):213. PMID: 35260776; PMCID: PMC8904843.
    Citations: 14 Article has an altmetric score of 2
    Translation:HumansCells
  6. Feng W, Dean DC, Hornicek FJ, Spentzos D, Hoffman RM, Shi H, Duan Z. Myc is a prognostic biomarker and potential therapeutic target in osteosarcoma. Ther Adv Med Oncol. 2020; 12:1758835920922055. PMID: 32426053; PMCID: PMC7222246.
    Citations: 37 Article has an altmetric score of 11
  7. Lietz CE, Garbutt C, Barry WT, Deshpande V, Chen YL, Lozano-Calderon SA, Wang Y, Lawney B, Ebb D, Cote GM, Duan Z, Hornicek FJ, Choy E, Petur Nielsen G, Haibe-Kains B, Quackenbush J, Spentzos D. MicroRNA-mRNA networks define translatable molecular outcome phenotypes in osteosarcoma. Sci Rep. 2020 03 10; 10(1):4409. PMID: 32157112; PMCID: PMC7064533.
    Citations: 7
    Fields: SciScienceTranslation:Humans
  8. Guarnerio J, Zhang Y, Cheloni G, Panella R, Katon JM, Simpson M, Matsumoto A, Papa A, Loretelli C, Petri A, Kauppinen S, Garbutt C, Nielsen GP, Deshpande V, Castillo-Martin M, Cordon-Cardo C, Spentzos D, Clohessy JG, Batish M, Pandolfi PP. Author Correction: Intragenic antagonistic roles of protein and circRNA in tumorigenesis. Cell Res. 2020 Feb; 30(2):188. PMID: 31911670.
    Citations:
    Fields: CelCell Biology
  9. Fountzilas E, Markou K, Vlachtsis K, Nikolaou A, Arapantoni-Dadioti P, Ntoula E, Tassopoulos G, Bobos M, Konstantinopoulos P, Fountzilas G, Spentzos D. Identification and validation of gene expression models that predict clinical outcome in patients with early-stage laryngeal cancer. Ann Oncol. 2012 Aug; 23(8):2146-2153. PMID: 32018475.
    Citations: -1
  10. Lozano Calderón SA, Garbutt C, Kim J, Lietz CE, Chen YL, Bernstein K, Chebib I, Nielsen GP, Deshpande V, Rubio R, Wang YE, Quackenbush J, Delaney T, Raskin K, Schwab J, Cote G, Spentzos D. Clinical and Molecular Analysis of Pathologic Fracture-associated Osteosarcoma: MicroRNA profile Is Different and Correlates with Prognosis. Clin Orthop Relat Res. 2019 Sep; 477(9):2114-2126. PMID: 31389890; PMCID: PMC7000091.
    Citations: 11 Article has an altmetric score of 13
    Fields: OrtOrthopedicsTranslation:Humans
  11. Austin DC, Wu JS, Spentzos D, Goldsmith JD, Anderson ME. A Collision Tumor Involving a Primary Leiomyosarcoma of the Lower Extremity and a Metastatic Medullary Thyroid Carcinoma: A Case Report. JBJS Case Connect. 2017 Oct-Dec; 7(4):e90. PMID: 29286973.
    Citations:
    Fields: OrtOrthopedicsTranslation:Humans
  12. Chen H, Garbutt CC, Spentzos D, Choy E, Hornicek FJ, Duan Z. Expression and Therapeutic Potential of SOX9 in Chordoma. Clin Cancer Res. 2017 Sep 01; 23(17):5176-5186. PMID: 28606919; PMCID: PMC5581713.
    Citations: 21 Article has an altmetric score of 1
    Fields: NeoNeoplasmsTranslation:HumansCells
  13. Hill KE, Kelly AD, Kuijjer ML, Barry W, Rattani A, Garbutt CC, Kissick H, Janeway K, Perez-Atayde A, Goldsmith J, Gebhardt MC, Arredouani MS, Cote G, Hornicek F, Choy E, Duan Z, Quackenbush J, Haibe-Kains B, Spentzos D. An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets. J Hematol Oncol. 2017 05 15; 10(1):107. PMID: 28506242; PMCID: PMC5433149.
    Citations: 21 Article has an altmetric score of 17
    Fields: HemHematologyNeoNeoplasmsTranslation:HumansCells
  14. Osaka E, Kelly AD, Spentzos D, Choy E, Yang X, Shen JK, Yang P, Mankin HJ, Hornicek FJ, Duan Z. MicroRNA-155 expression is independently predictive of outcome in chordoma. Oncotarget. 2015 Apr 20; 6(11):9125-39. PMID: 25823817; PMCID: PMC4496207.
    Citations: 20 Article has an altmetric score of 1
    Fields: NeoNeoplasmsTranslation:HumansCells
  15. Glass K, Quackenbush J, Spentzos D, Haibe-Kains B, Yuan GC. A network model for angiogenesis in ovarian cancer. BMC Bioinformatics. 2015 Apr 11; 16:115. PMID: 25888305; PMCID: PMC4408593.
    Citations: 33 Article has an altmetric score of 12
    Fields: ComComputational BiologyTranslation:Humans
  16. Duan Z, Shen J, Yang X, Yang P, Osaka E, Choy E, Cote G, Harmon D, Zhang Y, Nielsen GP, Spentzos D, Mankin H, Hornicek F. Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma. J Orthop Res. 2014 May; 32(5):695-701. PMID: 24501096; PMCID: PMC4049352.
    Citations: 23 Article has an altmetric score of 1
    Fields: OrtOrthopedicsTranslation:HumansCells
  17. Kelly AD, Hill KE, Correll M, Hu L, Wang YE, Rubio R, Duan S, Quackenbush J, Spentzos D. Next-generation sequencing and microarray-based interrogation of microRNAs from formalin-fixed, paraffin-embedded tissue: preliminary assessment of cross-platform concordance. Genomics. 2013 Jul; 102(1):8-14. PMID: 23562991.
    Citations: 16
    Fields: GenGeneticsTranslation:Humans
  18. Schwede M, Spentzos D, Bentink S, Hofmann O, Haibe-Kains B, Harrington D, Quackenbush J, Culhane AC. Stem cell-like gene expression in ovarian cancer predicts type II subtype and prognosis. PLoS One. 2013; 8(3):e57799. PMID: 23536770.
    Citations: 19
    Fields: MedMedicine (General)SciScienceTranslation:HumansCells
  19. Kelly AD, Haibe-Kains B, Janeway KA, Hill KE, Howe E, Goldsmith J, Kurek K, Perez-Atayde AR, Francoeur N, Fan JB, April C, Schneider H, Gebhardt MC, Culhane A, Quackenbush J, Spentzos D. MicroRNA paraffin-based studies in osteosarcoma reveal reproducible independent prognostic profiles at 14q32. Genome Med. 2013; 5(1):2. PMID: 23339462.
    Citations: 66
    Fields: GenGenetics, Medical
  20. Fountzilas E, Kelly AD, Perez-Atayde AR, Goldsmith J, Konstantinopoulos PA, Francoeur N, Correll M, Rubio R, Hu L, Gebhardt MC, Quackenbush J, Spentzos D. A microRNA activity map of human mesenchymal tumors: connections to oncogenic pathways; an integrative transcriptomic study. BMC Genomics. 2012 Jul 23; 13:332. PMID: 22823907.
    Citations: 1
    Fields: GenGeneticsTranslation:HumansCells
  21. Fountzilas E, Markou K, Vlachtsis K, Nikolaou A, Arapantoni-Dadioti P, Ntoula E, Tassopoulos G, Bobos M, Konstantinopoulos P, Fountzilas G, Spentzos D. Identification and validation of gene expression models that predict clinical outcome in patients with early-stage laryngeal cancer. Ann Oncol. 2012 Aug; 23(8):2146-2153. PMID: 22219018; PMCID: PMC3493135.
    Citations: 16
    Fields: NeoNeoplasmsTranslation:Humans
  22. Kelly AD, Breitkopf SB, Yuan M, Goldsmith J, Spentzos D, Asara JM. Metabolomic profiling from formalin-fixed, paraffin-embedded tumor tissue using targeted LC/MS/MS: application in sarcoma. PLoS One. 2011; 6(10):e25357. PMID: 21984915.
    Citations: 40
    Fields: MedMedicine (General)SciScienceTranslation:HumansCells
  23. Konstantinopoulos PA, Spentzos D, Fountzilas E, Francoeur N, Sanisetty S, Grammatikos AP, Hecht JL, Cannistra SA. Keap1 mutations and Nrf2 pathway activation in epithelial ovarian cancer. Cancer Res. 2011 Aug 01; 71(15):5081-9. PMID: 21676886.
    Citations: 138
    Fields: NeoNeoplasmsTranslation:HumansCells
  24. Fountzilas E, Angouridakis N, Karasmanis I, Wirtz RM, Eleftheraki AG, Veltrup E, Markou K, Nikolaou A, Konstantinopoulos P, Kotoula V, Spentzos D, Fountzilas G. Prediction of clinical outcome in patients with primary laryngeal carcinoma using gene expression profiling. J Clin Oncol. 2011 May 20; 29(15_suppl):5505. PMID: 28021461.
    Citations: -1
  25. Konstantinopoulos PA, Cannistra SA, Fountzilas H, Culhane A, Pillay K, Rueda B, Cramer D, Seiden M, Birrer M, Coukos G, Zhang L, Quackenbush J, Spentzos D. Integrated analysis of multiple microarray datasets identifies a reproducible survival predictor in ovarian cancer. PLoS One. 2011 Mar 29; 6(3):e18202. PMID: 21479231.
    Citations: 20
    Fields: MedMedicine (General)SciScienceTranslation:HumansCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contact@catalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resources@hms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappt@hms.harvard.edu.
Spentzos's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (241)
Explore
_
Co-Authors (59)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
© 2025 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.