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profileConstance Cepko, Ph.D.

TitleBullard Professor of Genetics and Neuroscience
InstitutionHarvard Medical School
DepartmentGenetics
AddressHarvard Medical School
Genetics NRB Room 360
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-7618
Fax617/432-7595
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Other Positions
TitleProfessor of Ophthalmology
InstitutionMassachusetts Eye and Ear Infirmary
DepartmentOphthalmology


Collapse Mentoring 
Collapse completed student projects
Deciphering the Role of Alternative Splicing Factors Cugbp2 and Sfrs6 in Retinal Development
Summer, 06/11/07 - 08/17/07

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U01NS090449     (ENGERT, FLORIAN)Sep 30, 2014 - Jul 31, 2017
NIH/NINDS
Neural circuits in zebrafish: form, function and plasticity
Role: Principal Investigator

R01NS083848     (CEPKO, CONSTANCE L)Jul 1, 2013 - Apr 30, 2018
NIH/NINDS
Development of novel transsynaptic tracers for use in the central nervous system
Role: Principal Investigator

R01EY023291     (CEPKO, CONSTANCE L)Mar 1, 2013 - Feb 29, 2016
NIH/NEI
Gene therapy to support cone metabolism in retinitis pigmentosa
Role: Principal Investigator

R01EY014466     (CEPKO, CONSTANCE L)Jan 1, 2003 - Dec 31, 2008
NIH/NEI
Gene Expression Profiles of Retinal Degeneration
Role: Principal Investigator

R01EY013092     (CEPKO, CONSTANCE L)Sep 30, 1999 - Sep 29, 2002
NIH/NEI
GENE EXPRESSION IN SINGLE, IDENTIFIED CNS CELLS
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. da Silva S, Cepko CL. Fgf8 Expression and Degradation of Retinoic Acid Are Required for Patterning a High-Acuity Area in the Retina. Dev Cell. 2017 Jul 10; 42(1):68-81.e6. PMID: 28648799.
    View in: PubMed
  2. Chinchore Y, Begaj T, Wu D, Drokhlyansky E, Cepko CL. Glycolytic reliance promotes anabolism in photoreceptors. Elife. 2017 Jun 09; 6. PMID: 28598329.
    View in: PubMed
  3. Tang JCY, Rudolph S, Cepko CL. Viral Delivery of GFP-Dependent Recombinases to the Mouse Brain. Methods Mol Biol. 2017; 1642:109-126. PMID: 28815497.
    View in: PubMed
  4. Drokhlyansky E, Göz Aytürk D, Soh TK, Chrenek R, O'Loughlin E, Madore C, Butovsky O, Cepko CL. The brain parenchyma has a type I interferon response that can limit virus spread. Proc Natl Acad Sci U S A. 2017 Jan 03; 114(1):E95-E104. PMID: 27980033.
    View in: PubMed
  5. Shekhar K, Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M, Adiconis X, Levin JZ, Nemesh J, Goldman M, McCarroll SA, Cepko CL, Regev A, Sanes JR. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016 Aug 25; 166(5):1308-1323.e30. PMID: 27565351; PMCID: PMC5003425 [Available on 08/25/17].
  6. Tang JC, Drokhlyansky E, Etemad B, Rudolph S, Guo B, Wang S, Ellis EG, Li JZ, Cepko CL. Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. Elife. 2016 May 20; 5. PMID: 27205882; PMCID: PMC4922844.
  7. Wang S, Cepko CL. Photoreceptor Fate Determination in the Vertebrate Retina. Invest Ophthalmol Vis Sci. 2016 Apr 01; 57(5):ORSFe1-6. PMID: 27116662.
    View in: PubMed
  8. Beier KT, Mundell NA, Pan YA, Cepko CL. Anterograde or Retrograde Transsynaptic Circuit Tracing in Vertebrates with Vesicular Stomatitis Virus Vectors. Curr Protoc Neurosci. 2016 Jan 04; 74:1.26.1-27. PMID: 26729030; PMCID: PMC4776322 [Available on 01/04/17].
  9. Xiong W, Cepko C. Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages. Adv Exp Med Biol. 2016; 854:501-7. PMID: 26427452.
    View in: PubMed
  10. Cepko CL. The Determination of Rod and Cone Photoreceptor Fate. Annu Rev Vis Sci. 2015 Nov 24; 1:211-234. PMID: 28532380.
    View in: PubMed
  11. Drokhlyansky E, Soh TK, Cepko CL. Preferential Budding of Vesicular Stomatitis Virus from the Basolateral Surface of Polarized Epithelial Cells Is Not Solely Directed by Matrix Protein or Glycoprotein. J Virol. 2015 Nov; 89(22):11718-22. PMID: 26339064; PMCID: PMC4645653.
  12. Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein AR. Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons. Neuron. 2015 Sep 02; 87(5):999-1007. PMID: 26299474; PMCID: PMC4581718.
  13. Mayer C, Jaglin XH, Cobbs LV, Bandler RC, Streicher C, Cepko CL, Hippenmeyer S, Fishell G. Clonally Related Forebrain Interneurons Disperse Broadly across Both Functional Areas and Structural Boundaries. Neuron. 2015 Sep 02; 87(5):989-98. PMID: 26299473; PMCID: PMC4560602.
  14. Tang JC, Rudolph S, Dhande OS, Abraira VE, Choi S, Lapan SW, Drew IR, Drokhlyansky E, Huberman AD, Regehr WG, Cepko CL. Cell type-specific manipulation with GFP-dependent Cre recombinase. Nat Neurosci. 2015 Sep; 18(9):1334-41. PMID: 26258682; PMCID: PMC4839275.
  15. Nassi JJ, Cepko CL, Born RT, Beier KT. Neuroanatomy goes viral! Front Neuroanat. 2015; 9:80. PMID: 26190977; PMCID: PMC4486834.
  16. Cepko C, Punzo C. Cell metabolism: Sugar for sight. Nature. 2015 Jun 25; 522(7557):428-9. PMID: 26108850.
    View in: PubMed
  17. Fuentealba LC, Rompani SB, Parraguez JI, Obernier K, Romero R, Cepko CL, Alvarez-Buylla A. Embryonic Origin of Postnatal Neural Stem Cells. Cell. 2015 Jun 18; 161(7):1644-55. PMID: 26091041; PMCID: PMC4475276.
  18. Fine I, Cepko CL, Landy MS. Vision research special issue: Sight restoration: Prosthetics, optogenetics and gene therapy. Vision Res. 2015 Jun; 111(Pt B):115-23. PMID: 25937376.
    View in: PubMed
  19. Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN. Lassa-vesicular stomatitis chimeric virus safely destroys brain tumors. J Virol. 2015 Jul; 89(13):6711-24. PMID: 25878115; PMCID: PMC4468483 [Available on 01/01/16].
  20. Mundell NA, Beier KT, Pan YA, Lapan SW, Göz Aytürk D, Berezovskii VK, Wark AR, Drokhlyansky E, Bielecki J, Born RT, Schier AF, Cepko CL. Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms. J Comp Neurol. 2015 Aug 01; 523(11):1639-63. PMID: 25688551; PMCID: PMC4458151.
  21. Xiong W, MacColl Garfinkel AE, Li Y, Benowitz LI, Cepko CL. NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. J Clin Invest. 2015 Apr; 125(4):1433-45. PMID: 25798616; PMCID: PMC4396467.
  22. Wang S, Sengel C, Emerson MM, Cepko CL. A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina. Dev Cell. 2014 Sep 08; 30(5):513-27. PMID: 25155555; PMCID: PMC4304698.
  23. Cepko C. Intrinsically different retinal progenitor cells produce specific types of progeny. Nat Rev Neurosci. 2014 Sep; 15(9):615-27. PMID: 25096185.
    View in: PubMed
  24. Sukhdeo K, Koch CE, Miller TE, Zhou H, Rivera M, Yan K, Cepko CL, Lathia JD, Rich JN. The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina. Exp Eye Res. 2014 Feb; 119:106-10. PMID: 24246263; PMCID: PMC3986349.
  25. Mizeracka K, Trimarchi JM, Stadler MB, Cepko CL. Analysis of gene expression in wild-type and Notch1 mutant retinal cells by single cell profiling. Dev Dyn. 2013 Oct; 242(10):1147-59. PMID: 23813500; PMCID: PMC3882027.
  26. Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B, Cepko CL. A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell. 2013 Aug 15; 154(4):928-39. PMID: 23953120; PMCID: PMC4096992.
  27. Jiang H, Wang L, Beier KT, Cepko CL, Fekete DM, Brigande JV. Lineage analysis of the late otocyst stage mouse inner ear by transuterine microinjection of a retroviral vector encoding alkaline phosphatase and an oligonucleotide library. PLoS One. 2013; 8(7):e69314. PMID: 23935981; PMCID: PMC3723842.
  28. Emerson MM, Surzenko N, Goetz JJ, Trimarchi J, Cepko CL. Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors. Dev Cell. 2013 Jul 15; 26(1):59-72. PMID: 23867227; PMCID: PMC3819454.
  29. Mizeracka K, DeMaso CR, Cepko CL. Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate. Development. 2013 Aug; 140(15):3188-97. PMID: 23824579; PMCID: PMC3931735.
  30. Cepko CL, Vandenberghe LH. Retinal gene therapy coming of age. Hum Gene Ther. 2013 Mar; 24(3):242-4. PMID: 23458444; PMCID: PMC4530353.
  31. Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo. Front Neural Circuits. 2013; 7:11. PMID: 23403489; PMCID: PMC3566411.
  32. Whited JL, Tsai SL, Beier KT, White JN, Piekarski N, Hanken J, Cepko CL, Tabin CJ. Pseudotyped retroviruses for infecting axolotl in vivo and in vitro. Development. 2013 Mar; 140(5):1137-46. PMID: 23344705; PMCID: PMC3583047.
  33. Beier KT, Borghuis BG, El-Danaf RN, Huberman AD, Demb JB, Cepko CL. Transsynaptic tracing with vesicular stomatitis virus reveals novel retinal circuitry. J Neurosci. 2013 Jan 02; 33(1):35-51. PMID: 23283320; PMCID: PMC3711516.
  34. Beier K, Cepko C. Viral tracing of genetically defined neural circuitry. J Vis Exp. 2012 Oct 17; (68). PMID: 23117695; PMCID: PMC3490305.
  35. Cepko CL. Emerging gene therapies for retinal degenerations. J Neurosci. 2012 May 09; 32(19):6415-20. PMID: 22573664; PMCID: PMC3392151.
  36. Roesch K, Stadler MB, Cepko CL. Gene expression changes within Müller glial cells in retinitis pigmentosa. Mol Vis. 2012; 18:1197-214. PMID: 22665967; PMCID: PMC3365136.
  37. Hafler BP, Surzenko N, Beier KT, Punzo C, Trimarchi JM, Kong JH, Cepko CL. Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7882-7. PMID: 22543161; PMCID: PMC3356608.
  38. Punzo C, Xiong W, Cepko CL. Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame? J Biol Chem. 2012 Jan 13; 287(3):1642-8. PMID: 22074929; PMCID: PMC3265845.
  39. Emerson MM, Cepko CL. Identification of a retina-specific Otx2 enhancer element active in immature developing photoreceptors. Dev Biol. 2011 Dec 01; 360(1):241-55. PMID: 21963459; PMCID: PMC3339761.
  40. Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith LE, Siemann DW, Kladde MP, Cepko CL, Lu J. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6. PMID: 21896759; PMCID: PMC3174592.
  41. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15414-9. PMID: 21825165; PMCID: PMC3174680.
  42. Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011 Jul 29; 18(7):833-8. PMID: 21802004; PMCID: PMC3154086.
  43. Cherry TJ, Wang S, Bormuth I, Schwab M, Olson J, Cepko CL. NeuroD factors regulate cell fate and neurite stratification in the developing retina. J Neurosci. 2011 May 18; 31(20):7365-79. PMID: 21593321; PMCID: PMC3135085.
  44. Beier KT, Samson ME, Matsuda T, Cepko CL. Conditional expression of the TVA receptor allows clonal analysis of descendents from Cre-expressing progenitor cells. Dev Biol. 2011 May 15; 353(2):309-20. PMID: 21397594; PMCID: PMC3100772.
  45. Huynh MA, Ikeuchi Y, Netherton S, de la Torre-Ubieta L, Kanadia R, Stegmüller J, Cepko C, Bonni S, Bonni A. An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. 2011 Mar 10; 69(5):930-44. PMID: 21382553; PMCID: PMC3073069.
  46. Billings NA, Emerson MM, Cepko CL. Analysis of thyroid response element activity during retinal development. PLoS One. 2010 Oct 29; 5(10):e13739. PMID: 21060789; PMCID: PMC2966421.
  47. Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR. Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein. ACS Chem Biol. 2010 Aug 20; 5(8):747-52. PMID: 20545362; PMCID: PMC2924640.
  48. Cepko C. Neuroscience. Seeing the light of day. Science. 2010 Jul 23; 329(5990):403-4. PMID: 20651144.
    View in: PubMed
  49. Rompani SB, Cepko CL. A common progenitor for retinal astrocytes and oligodendrocytes. J Neurosci. 2010 Apr 07; 30(14):4970-80. PMID: 20371817; PMCID: PMC3536471.
  50. Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature. 2010 Jan 21; 463(7279):374-8. PMID: 20090754; PMCID: PMC2943587.
  51. Kanadia RN, Cepko CL. Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development. Genes Dev. 2010 Feb 01; 24(3):229-34. PMID: 20080942; PMCID: PMC2811824.
  52. Samson M, Emerson MM, Cepko CL. Robust marking of photoreceptor cells and pinealocytes with several reporters under control of the Crx gene. Dev Dyn. 2009 Dec; 238(12):3218-25. PMID: 19882727; PMCID: PMC2965029.
  53. Trimarchi JM, Cho SH, Cepko CL. Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. Dev Dyn. 2009 Sep; 238(9):2327-9. PMID: 19449303; PMCID: PMC2916742.
  54. Cherry TJ, Trimarchi JM, Stadler MB, Cepko CL. Development and diversification of retinal amacrine interneurons at single cell resolution. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9495-500. PMID: 19470466; PMCID: PMC2686638.
  55. Jadhav AP, Roesch K, Cepko CL. Development and neurogenic potential of Müller glial cells in the vertebrate retina. Prog Retin Eye Res. 2009 Jul; 28(4):249-62. PMID: 19465144; PMCID: PMC3233204.
  56. Dyer MA, Martins R, da Silva Filho M, Muniz JA, Silveira LC, Cepko CL, Finlay BL. Developmental sources of conservation and variation in the evolution of the primate eye. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8963-8. PMID: 19451636; PMCID: PMC2690025.
  57. Chen B, Cepko CL. HDAC4 regulates neuronal survival in normal and diseased retinas. Science. 2009 Jan 09; 323(5911):256-9. PMID: 19131628; PMCID: PMC3339762.
  58. Punzo C, Kornacker K, Cepko CL. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci. 2009 Jan; 12(1):44-52. PMID: 19060896; PMCID: PMC3339764.
  59. Kanadia RN, Clark VE, Punzo C, Trimarchi JM, Cepko CL. Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons. Development. 2008 Dec; 135(23):3923-33. PMID: 18987029; PMCID: PMC3593640.
  60. Trimarchi JM, Harpavat S, Billings NA, Cepko CL. Thyroid hormone components are expressed in three sequential waves during development of the chick retina. BMC Dev Biol. 2008 Oct 14; 8:101. PMID: 18854032; PMCID: PMC2579430.
  61. Kim DS, Matsuda T, Cepko CL. A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression. J Neurosci. 2008 Jul 30; 28(31):7748-64. PMID: 18667607; PMCID: PMC2714707.
  62. Roesch K, Jadhav AP, Trimarchi JM, Stadler MB, Roska B, Sun BB, Cepko CL. The transcriptome of retinal Müller glial cells. J Comp Neurol. 2008 Jul 10; 509(2):225-38. PMID: 18465787; PMCID: PMC2665263.
  63. Nygaard V, Liu F, Holden M, Kuo WP, Trimarchi J, Ohno-Machado L, Cepko CL, Frigessi A, Glad IK, Wiel MA, Hovig E, Lyng H. Validation of oligoarrays for quantitative exploration of the transcriptome. BMC Genomics. 2008 May 30; 9:258. PMID: 18513391; PMCID: PMC2430212.
  64. Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008 May 07; 28(19):4878-87. PMID: 18463241; PMCID: PMC3325486.
  65. Lagali PS, Balya D, Awatramani GB, Münch TA, Kim DS, Busskamp V, Cepko CL, Roska B. Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci. 2008 Jun; 11(6):667-75. PMID: 18432197.
    View in: PubMed
  66. Kim DS, Ross SE, Trimarchi JM, Aach J, Greenberg ME, Cepko CL. Identification of molecular markers of bipolar cells in the murine retina. J Comp Neurol. 2008 Apr 10; 507(5):1795-810. PMID: 18260140; PMCID: PMC2665264.
  67. Punzo C, Cepko CL. Ultrasound-guided in utero injections allow studies of the development and function of the eye. Dev Dyn. 2008 Apr; 237(4):1034-42. PMID: 18351670; PMCID: PMC2532702.
  68. Trimarchi JM, Stadler MB, Cepko CL. Individual retinal progenitor cells display extensive heterogeneity of gene expression. PLoS One. 2008 Feb 13; 3(2):e1588. PMID: 18270576; PMCID: PMC2220035.
  69. Morrow EM, Chen CM, Cepko CL. Temporal order of bipolar cell genesis in the neural retina. Neural Dev. 2008 Jan 23; 3:2. PMID: 18215319; PMCID: PMC2248187.
  70. Matsuda T, Cepko CL. Analysis of gene function in the retina. Methods Mol Biol. 2008; 423:259-78. PMID: 18370205.
    View in: PubMed
  71. Rompani SB, Cepko CL. Retinal progenitor cells can produce restricted subsets of horizontal cells. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):192-7. PMID: 18162542; PMCID: PMC2224184.
  72. Hsiau TH, Diaconu C, Myers CA, Lee J, Cepko CL, Corbo JC. The cis-regulatory logic of the mammalian photoreceptor transcriptional network. PLoS One. 2007 Jul 25; 2(7):e643. PMID: 17653270; PMCID: PMC1916400.
  73. Corbo JC, Myers CA, Lawrence KA, Jadhav AP, Cepko CL. A typology of photoreceptor gene expression patterns in the mouse. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12069-74. PMID: 17620597; PMCID: PMC1913549.
  74. Chen B, Cepko CL. Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. BMC Dev Biol. 2007 Jun 29; 7:78. PMID: 17603891; PMCID: PMC1914050.
  75. Trimarchi JM, Stadler MB, Roska B, Billings N, Sun B, Bartch B, Cepko CL. Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling. J Comp Neurol. 2007 Jun 20; 502(6):1047-65. PMID: 17444492.
    View in: PubMed
  76. Liu F, Jenssen TK, Trimarchi J, Punzo C, Cepko CL, Ohno-Machado L, Hovig E, Kuo WP. Comparison of hybridization-based and sequencing-based gene expression technologies on biological replicates. BMC Genomics. 2007 Jun 07; 8:153. PMID: 17555589; PMCID: PMC1899500.
  77. Viney TJ, Balint K, Hillier D, Siegert S, Boldogkoi Z, Enquist LW, Meister M, Cepko CL, Roska B. Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. Curr Biol. 2007 Jun 05; 17(11):981-8. PMID: 17524644.
    View in: PubMed
  78. Galante PA, Trimarchi J, Cepko CL, de Souza SJ, Ohno-Machado L, Kuo WP. Automatic correspondence of tags and genes (ACTG): a tool for the analysis of SAGE, MPSS and SBS data. Bioinformatics. 2007 Apr 01; 23(7):903-5. PMID: 17277333.
    View in: PubMed
  79. Punzo C, Cepko C. Cellular responses to photoreceptor death in the rd1 mouse model of retinal degeneration. Invest Ophthalmol Vis Sci. 2007 Feb; 48(2):849-57. PMID: 17251487.
    View in: PubMed
  80. Matsuda T, Cepko CL. Controlled expression of transgenes introduced by in vivo electroporation. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):1027-32. PMID: 17209010; PMCID: PMC1764220.
  81. Jadhav AP, Cho SH, Cepko CL. Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):18998-9003. PMID: 17148603; PMCID: PMC1682012.
  82. Young-Pearse TL, Ivic L, Kriegstein AR, Cepko CL. Characterization of mice with targeted deletion of glycine receptor alpha 2. Mol Cell Biol. 2006 Aug; 26(15):5728-34. PMID: 16847326; PMCID: PMC1592777.
  83. Cho SH, Cepko CL. Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. Development. 2006 Aug; 133(16):3167-77. PMID: 16854977.
    View in: PubMed
  84. Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK. A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol. 2006 Jul; 24(7):832-40. PMID: 16823376.
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  85. Wildner H, Müller T, Cho SH, Bröhl D, Cepko CL, Guillemot F, Birchmeier C. dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development. Development. 2006 Jun; 133(11):2105-13. PMID: 16690754.
    View in: PubMed
  86. Jadhav AP, Mason HA, Cepko CL. Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development. 2006 Mar; 133(5):913-23. PMID: 16452096.
    View in: PubMed
  87. Harpavat S, Cepko CL. RCAS-RNAi: a loss-of-function method for the developing chick retina. BMC Dev Biol. 2006 Jan 22; 6:2. PMID: 16426460; PMCID: PMC1402266.
  88. Cepko CL. Effect of gene expression on cone survival in retinitis pigmentosa. Retina. 2005 Dec; 25(8 Suppl):S21-S24. PMID: 16374320.
    View in: PubMed
  89. Sen J, Harpavat S, Peters MA, Cepko CL. Retinoic acid regulates the expression of dorsoventral topographic guidance molecules in the chick retina. Development. 2005 Dec; 132(23):5147-59. PMID: 16251210.
    View in: PubMed
  90. Corbo JC, Cepko CL. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. PLoS Genet. 2005 Aug; 1(2):e11. PMID: 16110338; PMCID: PMC1186732.
  91. Rowan S, Cepko CL. A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells. Dev Biol. 2005 May 15; 281(2):240-55. PMID: 15893976.
    View in: PubMed
  92. Young TL, Matsuda T, Cepko CL. The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina. Curr Biol. 2005 Mar 29; 15(6):501-12. PMID: 15797018.
    View in: PubMed
  93. Schulte D, Peters MA, Sen J, Cepko CL. The rod photoreceptor pattern is set at the optic vesicle stage and requires spatially restricted cVax expression. J Neurosci. 2005 Mar 16; 25(11):2823-31. PMID: 15772342.
    View in: PubMed
  94. Morrow EM, Furukawa T, Raviola E, Cepko CL. Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice. BMC Neurosci. 2005 Jan 27; 6:5. PMID: 15676071; PMCID: PMC548520.
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  101. Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet. 2004 Apr; 36(4):351-60. PMID: 14991054.
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  102. Pignatelli V, Cepko CL, Strettoi E. Inner retinal abnormalities in a mouse model of Leber's congenital amaurosis. J Comp Neurol. 2004 Feb 09; 469(3):351-9. PMID: 14730587.
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  104. Matsuda T, Cepko CL. Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):16-22. PMID: 14603031; PMCID: PMC314130.
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  107. Jin Z, Zhang J, Klar A, Chédotal A, Rao Y, Cepko CL, Bao ZZ. Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina. Development. 2003 Mar; 130(6):1037-48. PMID: 12571096.
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  110. Chen CM, Cepko CL. The chicken RaxL gene plays a role in the initiation of photoreceptor differentiation. Development. 2002 Dec; 129(23):5363-75. PMID: 12403708.
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  112. Goh KL, Cai L, Cepko CL, Gertler FB. Ena/VASP proteins regulate cortical neuronal positioning. Curr Biol. 2002 Apr 02; 12(7):565-9. PMID: 11937025.
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  113. Furukawa A, Koike C, Lippincott P, Cepko CL, Furukawa T. The mouse Crx 5'-upstream transgene sequence directs cell-specific and developmentally regulated expression in retinal photoreceptor cells. J Neurosci. 2002 Mar 01; 22(5):1640-7. PMID: 11880494.
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  114. Bowne SJ, Sullivan LS, Blanton SH, Cepko CL, Blackshaw S, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP. Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. Hum Mol Genet. 2002 Mar 01; 11(5):559-68. PMID: 11875050; PMCID: PMC2585828.
  115. Szele FG, Chin HK, Rowlson MA, Cepko CL. Sox-9 and cDachsund-2 expression in the developing chick telencephalon. Mech Dev. 2002 Mar; 112(1-2):179-82. PMID: 11850191.
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  118. Chang B, Smith RS, Peters M, Savinova OV, Hawes NL, Zabaleta A, Nusinowitz S, Martin JE, Davisson ML, Cepko CL, Hogan BL, John SW. Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. BMC Genet. 2001; 2:18. PMID: 11722794; PMCID: PMC59999.
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  135. Dyer MA, Cepko CL. Control of Müller glial cell proliferation and activation following retinal injury. Nat Neurosci. 2000 Sep; 3(9):873-80. PMID: 10966617.
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  137. Liu W, Khare SL, Liang X, Peters MA, Liu X, Cepko CL, Xiang M. All Brn3 genes can promote retinal ganglion cell differentiation in the chick. Development. 2000 Aug; 127(15):3237-47. PMID: 10887080.
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  138. Cai L, Morrow EM, Cepko CL. Misexpression of basic helix-loop-helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival. Development. 2000 Jul; 127(14):3021-30. PMID: 10862740.
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  148. Schulte D, Furukawa T, Peters MA, Kozak CA, Cepko CL. Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map. Neuron. 1999 Nov; 24(3):541-53. PMID: 10595508.
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  154. Morrow EM, Furukawa T, Lee JE, Cepko CL. NeuroD regulates multiple functions in the developing neural retina in rodent. Development. 1999 Jan; 126(1):23-36. PMID: 9834183.
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  164. Golden JA, Zitz JC, McFadden K, Cepko CL. Cell migration in the developing chick diencephalon. Development. 1997 Sep; 124(18):3525-33. PMID: 9342045.
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  167. Ezzeddine ZD, Yang X, DeChiara T, Yancopoulos G, Cepko CL. Postmitotic cells fated to become rod photoreceptors can be respecified by CNTF treatment of the retina. Development. 1997 Mar; 124(5):1055-67. PMID: 9056780.
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  168. Bao ZZ, Cepko CL. The expression and function of Notch pathway genes in the developing rat eye. J Neurosci. 1997 Feb 15; 17(4):1425-34. PMID: 9006984.
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  186. Sucher NJ, Brose N, Deitcher DL, Awobuluyi M, Gasic GP, Bading H, Cepko CL, Greenberg ME, Jahn R, Heinemann SF, et al. Expression of endogenous NMDAR1 transcripts without receptor protein suggests post-transcriptional control in PC12 cells. J Biol Chem. 1993 Oct 25; 268(30):22299-304. PMID: 8226739.
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  196. Altshuler D, Cepko C. A temporally regulated, diffusible activity is required for rod photoreceptor development in vitro. Development. 1992 Apr; 114(4):947-57. PMID: 1618156.
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  211. Turner DL, Cepko CL. A common progenitor for neurons and glia persists in rat retina late in development. Nature. 1987 Jul 9-15; 328(6126):131-6. PMID: 3600789.
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  212. Price J, Turner D, Cepko C. Lineage analysis in the vertebrate nervous system by retrovirus-mediated gene transfer. Proc Natl Acad Sci U S A. 1987 Jan; 84(1):156-60. PMID: 3099292; PMCID: PMC304161.
  213. Choudary PV, Barranger JA, Tsuji S, Mayor J, LaMarca ME, Cepko CL, Mulligan RC, Ginns EI. Retrovirus-mediated transfer of the human glucocerebrosidase gene to Gaucher fibroblasts. Mol Biol Med. 1986 Jun; 3(3):293-9. PMID: 3736391.
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  214. Jat PS, Cepko CL, Mulligan RC, Sharp PA. Recombinant retroviruses encoding simian virus 40 large T antigen and polyomavirus large and middle T antigens. Mol Cell Biol. 1986 Apr; 6(4):1204-17. PMID: 3023876; PMCID: PMC367632.
  215. Roberts BE, Miller JS, Kimelman D, Cepko CL, Lemischka IR, Mulligan RC. Individual adenovirus type 5 early region 1A gene products elicit distinct alterations of cellular morphology and gene expression. J Virol. 1985 Nov; 56(2):404-13. PMID: 4057356; PMCID: PMC252593.
  216. Cepko CL, Roberts BE, Mulligan RC. Construction and applications of a highly transmissible murine retrovirus shuttle vector. Cell. 1984 Jul; 37(3):1053-62. PMID: 6331674.
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  217. Cepko CL, Sharp PA. Analysis of Ad5 hexon and 100K ts mutants using conformation-specific monoclonal antibodies. Virology. 1983 Aug; 129(1):137-54. PMID: 6612996.
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  218. Cepko CL, Sharp PA. Aberrant distribution of human adenovirus type 2 late proteins in monkey kidney cells. J Virol. 1983 Apr; 46(1):302-6. PMID: 6402607; PMCID: PMC255123.
  219. Cepko CL, Sharp PA. Assembly of adenovirus major capsid protein is mediated by a nonvirion protein. Cell. 1982 Dec; 31(2 Pt 1):407-15. PMID: 7159928.
    View in: PubMed
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