Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Constance Cepko, Ph.D.

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Other Positions
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Mentoring
completed student projects
Deciphering the Role of Alternative Splicing Factors Cugbp2 and Sfrs6 in Retinal Development
Summer, 06/11/07 - 08/17/07

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R01EY029348 (CEPKO, CONSTANCE L) Apr 1, 2019 - Mar 31, 2024
    NIH
    AAV Induced Toxicity in the Eye
    Role: Principal Investigator
  2. R01EY029771 (CEPKO, CONSTANCE L) Jan 1, 2019 - Jun 30, 2024
    NIH
    Determination of Cone Photoreceptor Fate
    Role: Principal Investigator
  3. R21AG059157 (CEPKO, CONSTANCE L) Aug 15, 2018 - Apr 30, 2021
    NIH
    Gene Therapy for Alzheimer's Disease
    Role: Principal Investigator
  4. U01NS090449 (ENGERT, FLORIAN) Sep 30, 2014 - Jul 31, 2018
    NIH
    Neural circuits in zebrafish: form, function and plasticity
    Role: Principal Investigator
  5. R01NS083848 (CEPKO, CONSTANCE L) Jul 1, 2013 - Apr 30, 2019
    NIH
    Development of novel transsynaptic tracers for use in the central nervous system
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Displaying 25 of 254 total Publications Show all
  1. Krause TB, Cepko CL. Abortive and productive infection of CNS cell types following in vivo delivery of VSV. Proc Natl Acad Sci U S A. 2024 Aug 27; 121(35):e2406421121. PMID: 39159381; PMCID: PMC11363278.
    Citations:
    Fields: SciScienceTranslation:AnimalsCells
  2. Avilés EC, Wang SK, Patel S, Shi S, Lin L, Kefalov VJ, Goodrich LV, Cepko CL, Xue Y. High temporal frequency light response in mouse retina requires FAT3 signaling in bipolar cells. bioRxiv. 2024 Jun 28. PMID: 37961274; PMCID: PMC10635074.
    Citations:
  3. Xue Y, Zhou Y, Cepko CL. Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model. Elife. 2024 May 10; 12. PMID: 38727583; PMCID: PMC11087050.
    Citations: 1
    Fields: BioBiologyTranslation:AnimalsCells
  4. Xue Y, Cepko CL. Gene Therapies for Retinitis Pigmentosa that Target Glucose Metabolism. Cold Spring Harb Perspect Med. 2024 05 02; 14(5). PMID: 37460158; PMCID: PMC11065158.
    Citations: 2
    Fields: MedMedicine (General)Translation:HumansAnimalsCells
  5. Choi J, Joisher HNV, Gill HK, Lin L, Cepko C. Characterization of the development of the high-acuity area of the chick retina. Dev Biol. 2024 Jul; 511:39-52. PMID: 38548147.
    Citations:
    Fields: BioBiologyEmbEmbryologyTranslation:AnimalsCells
  6. Xue Y, Zhou Y, Cepko CL. Txnip deletions and missense alleles prolong the survival of cones in a retinitis pigmentosa mouse model. bioRxiv. 2024 Mar 20. PMID: 38370727; PMCID: PMC10871187.
    Citations:
  7. Hong F, Kishi JY, Delgado RN, Jeong J, Saka SK, Su H, Cepko CL, Yin P. Thermal-plex: fluidic-free, rapid sequential multiplexed imaging with DNA-encoded thermal channels. Nat Methods. 2024 Feb; 21(2):331-341. PMID: 38151595; PMCID: PMC10864187.
    Citations: 1
    Fields: CliClinical Laboratory Techniques
  8. Xue Y, Sun X, Wang SK, Collin GB, Kefalov VJ, Cepko CL. Chromophore supply modulates cone function and survival in retinitis pigmentosa mouse models. Proc Natl Acad Sci U S A. 2023 06 06; 120(23):e2217885120. PMID: 37252956; PMCID: PMC10266038.
    Citations: 5
    Fields: SciScienceTranslation:AnimalsCells
  9. Dingus JG, Tang JCY, Amamoto R, Wallick GK, Cepko CL. A general approach for stabilizing nanobodies for intracellular expression. Elife. 2022 11 23; 11. PMID: 36416528; PMCID: PMC9683787.
    Citations: 10
    Fields: BioBiologyTranslation:AnimalsCells
  10. Kishi JY, Liu N, West ER, Sheng K, Jordanides JJ, Serrata M, Cepko CL, Saka SK, Yin P. Light-Seq: light-directed in situ barcoding of biomolecules in fixed cells and tissues for spatially indexed sequencing. Nat Methods. 2022 11; 19(11):1393-1402. PMID: 36216958; PMCID: PMC9636025.
    Citations: 23
    Fields: CliClinical Laboratory TechniquesTranslation:Animals
  11. Amamoto R, Wallick GK, Cepko CL. Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration. Elife. 2022 03 22; 11. PMID: 35315776; PMCID: PMC8940176.
    Citations: 10
    Fields: BioBiologyTranslation:AnimalsCells
  12. Wang SK, Cepko CL. Targeting Microglia to Treat Degenerative Eye Diseases. Front Immunol. 2022; 13:843558. PMID: 35251042; PMCID: PMC8891158.
    Citations: 19
    Fields: AllAllergy and ImmunologyTranslation:AnimalsCells
  13. Göz Aytürk D, You W, Cepko CL. Mouse Lines with Cre-Mediated Recombination in Retinal Amacrine Cells. eNeuro. 2022 Jan-Feb; 9(1). PMID: 35045975; PMCID: PMC8856716.
    Citations: 1
    Fields: BraBrainNeuNeurologyTranslation:AnimalsCells
  14. West ER, Lapan SW, Lee C, Kajderowicz KM, Li X, Cepko CL. Spatiotemporal patterns of neuronal subtype genesis suggest hierarchical development of retinal diversity. Cell Rep. 2022 01 04; 38(1):110191. PMID: 34986354.
    Citations: 11
    Fields: CelCell BiologyMolMolecular BiologyTranslation:AnimalsCells
  15. West ER, Cepko CL. Development and diversification of bipolar interneurons in the mammalian retina. Dev Biol. 2022 01; 481:30-42. PMID: 34534525.
    Citations: 12
    Fields: BioBiologyEmbEmbryologyTranslation:AnimalsCells
  16. Wang SK, Xue Y, Cepko CL. Augmentation of CD47/SIRPa signaling protects cones in genetic models of retinal degeneration. JCI Insight. 2021 08 23; 6(16). PMID: 34197341; PMCID: PMC8409989.
    Citations: 9
    Fields: MedMedicine (General)Translation:HumansAnimalsCells
  17. Xue Y, Wang SK, Rana P, West ER, Hong CM, Feng H, Wu DM, Cepko CL. AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa. Elife. 2021 04 13; 10. PMID: 33847261; PMCID: PMC8081528.
    Citations: 17
    Fields: BioBiologyTranslation:AnimalsCells
  18. Chan YK, Wang SK, Chu CJ, Copland DA, Letizia AJ, Costa Verdera H, Chiang JJ, Sethi M, Wang MK, Neidermyer WJ, Chan Y, Lim ET, Graveline AR, Sanchez M, Boyd RF, Vihtelic TS, Inciong RGCO, Slain JM, Alphonse PJ, Xue Y, Robinson-McCarthy LR, Tam JM, Jabbar MH, Sahu B, Adeniran JF, Muhuri M, Tai PWL, Xie J, Krause TB, Vernet A, Pezone M, Xiao R, Liu T, Wang W, Kaplan HJ, Gao G, Dick AD, Mingozzi F, McCall MA, Cepko CL, Church GM. Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses. Sci Transl Med. 2021 02 10; 13(580). PMID: 33568518; PMCID: PMC8409505.
    Citations: 93
    Fields: MedMedicine (General)SciScienceTranslation:AnimalsCells
  19. Wu DM, Ji X, Ivanchenko MV, Chung M, Piper M, Rana P, Wang SK, Xue Y, West E, Zhao SR, Xu H, Cicconet M, Xiong W, Cepko CL. Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa. JCI Insight. 2021 01 25; 6(2). PMID: 33491671; PMCID: PMC7934854.
    Citations: 28
    Fields: MedMedicine (General)Translation:HumansAnimalsCells
  20. Anahtar MN, McGrath GEG, Rabe BA, Tanner NA, White BA, Lennerz JKM, Branda JA, Cepko CL, Rosenberg ES. Clinical Assessment and Validation of a Rapid and Sensitive SARS-CoV-2 Test Using Reverse Transcription Loop-Mediated Isothermal Amplification Without the Need for RNA Extraction. Open Forum Infect Dis. 2021 Feb; 8(2):ofaa631. PMID: 34853795; PMCID: PMC7798487.
    Citations: 35
  21. Wang SK, Lapan SW, Hong CM, Krause TB, Cepko CL. In Situ Detection of Adeno-associated Viral Vector Genomes with SABER-FISH. Mol Ther Methods Clin Dev. 2020 Dec 11; 19:376-386. PMID: 33209963.
    Citations: 15
  22. Amamoto R, Garcia MD, West ER, Choi J, Lapan SW, Lane EA, Perrimon N, Cepko CL. Probe-Seq: Method for RNA Sequencing of Specific Cell Types from Animal Tissue. Bio Protoc. 2020 Sep 20; 10(18):e3749. PMID: 33659409; PMCID: PMC7842722.
    Citations:
  23. Rabe BA, Cepko C. SARS-CoV-2 detection using isothermal amplification and a rapid, inexpensive protocol for sample inactivation and purification. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24450-24458. PMID: 32900935; PMCID: PMC7533677.
    Citations: 148
    Fields: SciScienceTranslation:HumansCellsPHPublic Health
  24. Wang SK, Xue Y, Cepko CL. Microglia modulation by TGF-ß1 protects cones in mouse models of retinal degeneration. J Clin Invest. 2020 08 03; 130(8):4360-4369. PMID: 32352930; PMCID: PMC7410072.
    Citations: 40
    Fields: MedMedicine (General)Translation:HumansAnimalsCells
  25. Chan CSY, Lonfat N, Zhao R, Davis AE, Li L, Wu MR, Lin CH, Ji Z, Cepko CL, Wang S. Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina. Development. 2020 07 26; 147(14). PMID: 32631829; PMCID: PMC7406324.
    Citations: 19
    Fields: BioBiologyEmbEmbryologyTranslation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.