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Constance Cepko, Ph.D.

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Mentoring
Deciphering the Role of Alternative Splicing Factors Cugbp2 and Sfrs6 in Retinal Development
Summer, 06/11/07 - 08/17/07

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY029771 (CEPKO, CONSTANCE L) Jan 1, 2019 - Dec 31, 2023
    NIH/NEI
    Determination of Cone Photoreceptor Fate
    Role: Principal Investigator
  2. R21AG059157 (CEPKO, CONSTANCE L) Aug 15, 2018 - Apr 30, 2020
    NIH/NIA
    Gene Therapy for Alzheimer's Disease
    Role: Principal Investigator
  3. U01NS090449 (ENGERT, FLORIAN) Sep 30, 2014 - Jul 31, 2017
    NIH/NINDS
    Neural circuits in zebrafish: form, function and plasticity
    Role: Principal Investigator
  4. R01NS083848 (CEPKO, CONSTANCE L) Jul 1, 2013 - Apr 30, 2018
    NIH/NINDS
    Development of novel transsynaptic tracers for use in the central nervous system
    Role: Principal Investigator
  5. R01EY023291 (CEPKO, CONSTANCE L) Mar 1, 2013 - Feb 29, 2016
    NIH/NEI
    Gene therapy to support cone metabolism in retinitis pigmentosa
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Guo N, Soden ME, Herber C, Kim MT, Besnard A, Lin P, Ma X, Cepko CL, Zweifel LS, Sahay A. Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. Nat Med. 2018 May; 24(4):438-449. PMID: 29529016.
    Citations: 1     Fields:    
  2. Cheong SK, Xiong W, Strazzeri JM, Cepko CL, Williams DR, Merigan WH. In Vivo Functional Imaging of Retinal Neurons Using Red and Green Fluorescent Calcium Indicators. Adv Exp Med Biol. 2018; 1074:135-144. PMID: 29721937.
    Citations:    Fields:    
  3. da Silva S, Cepko CL. Fgf8 Expression and Degradation of Retinoic Acid Are Required for Patterning a High-Acuity Area in the Retina. Dev Cell. 2017 07 10; 42(1):68-81.e6. PMID: 28648799.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  4. Chinchore Y, Begaj T, Wu D, Drokhlyansky E, Cepko CL. Glycolytic reliance promotes anabolism in photoreceptors. Elife. 2017 06 09; 6. PMID: 28598329.
    Citations: 8     Fields:    Translation:AnimalsCells
  5. Tang JCY, Rudolph S, Cepko CL. Viral Delivery of GFP-Dependent Recombinases to the Mouse Brain. Methods Mol Biol. 2017; 1642:109-126. PMID: 28815497.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Drokhlyansky E, Göz Aytürk D, Soh TK, Chrenek R, O'Loughlin E, Madore C, Butovsky O, Cepko CL. The brain parenchyma has a type I interferon response that can limit virus spread. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):E95-E104. PMID: 27980033.
    Citations: 6     Fields:    Translation:AnimalsCells
  7. Shekhar K, Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M, Adiconis X, Levin JZ, Nemesh J, Goldman M, McCarroll SA, Cepko CL, Regev A, Sanes JR. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016 Aug 25; 166(5):1308-1323.e30. PMID: 27565351; PMCID: PMC5003425.
    Citations: 79     Fields:    Translation:AnimalsCells
  8. Tang JC, Drokhlyansky E, Etemad B, Rudolph S, Guo B, Wang S, Ellis EG, Li JZ, Cepko CL. Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. Elife. 2016 05 20; 5. PMID: 27205882; PMCID: PMC4922844.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  9. Wang S, Cepko CL. Photoreceptor Fate Determination in the Vertebrate Retina. Invest Ophthalmol Vis Sci. 2016 04 01; 57(5):ORSFe1-6. PMID: 27116662.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  10. Beier KT, Mundell NA, Pan YA, Cepko CL. Anterograde or Retrograde Transsynaptic Circuit Tracing in Vertebrates with Vesicular Stomatitis Virus Vectors. Curr Protoc Neurosci. 2016 Jan 04; 74:1.26.1-27. PMID: 26729030; PMCID: PMC4776322.
    Citations: 2     Fields:    Translation:AnimalsCells
  11. Xiong W, Cepko C. Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages. Adv Exp Med Biol. 2016; 854:501-7. PMID: 26427452.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  12. Cepko CL. The Determination of Rod and Cone Photoreceptor Fate. Annu Rev Vis Sci. 2015 Nov 24; 1:211-234. PMID: 28532380.
    Citations: 5     Fields:    
  13. Drokhlyansky E, Soh TK, Cepko CL. Preferential Budding of Vesicular Stomatitis Virus from the Basolateral Surface of Polarized Epithelial Cells Is Not Solely Directed by Matrix Protein or Glycoprotein. J Virol. 2015 Nov; 89(22):11718-22. PMID: 26339064; PMCID: PMC4645653.
    Citations: 2     Fields:    Translation:Cells
  14. Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein AR. Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons. Neuron. 2015 Sep 02; 87(5):999-1007. PMID: 26299474; PMCID: PMC4581718.
    Citations: 24     Fields:    Translation:AnimalsCells
  15. Mayer C, Jaglin XH, Cobbs LV, Bandler RC, Streicher C, Cepko CL, Hippenmeyer S, Fishell G. Clonally Related Forebrain Interneurons Disperse Broadly across Both Functional Areas and Structural Boundaries. Neuron. 2015 Sep 02; 87(5):989-98. PMID: 26299473; PMCID: PMC4560602.
    Citations: 21     Fields:    Translation:AnimalsCells
  16. Tang JC, Rudolph S, Dhande OS, Abraira VE, Choi S, Lapan SW, Drew IR, Drokhlyansky E, Huberman AD, Regehr WG, Cepko CL. Cell type-specific manipulation with GFP-dependent Cre recombinase. Nat Neurosci. 2015 Sep; 18(9):1334-41. PMID: 26258682; PMCID: PMC4839275.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  17. Nassi JJ, Cepko CL, Born RT, Beier KT. Neuroanatomy goes viral! Front Neuroanat. 2015; 9:80. PMID: 26190977.
    Citations: 27     
  18. Cepko C, Punzo C. Cell metabolism: Sugar for sight. Nature. 2015 Jun 25; 522(7557):428-9. PMID: 26108850.
    Citations:    
  19. Fuentealba LC, Rompani SB, Parraguez JI, Obernier K, Romero R, Cepko CL, Alvarez-Buylla A. Embryonic Origin of Postnatal Neural Stem Cells. Cell. 2015 Jun 18; 161(7):1644-55. PMID: 26091041; PMCID: PMC4475276.
    Citations: 69     Fields:    Translation:AnimalsCells
  20. Fine I, Cepko CL, Landy MS. Vision research special issue: Sight restoration: Prosthetics, optogenetics and gene therapy. Vision Res. 2015 Jun; 111(Pt B):115-23. PMID: 25937376.
    Citations: 2     Fields:    Translation:Humans
  21. Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN. Lassa-vesicular stomatitis chimeric virus safely destroys brain tumors. J Virol. 2015 Jul; 89(13):6711-24. PMID: 25878115; PMCID: PMC4468483.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  22. Mundell NA, Beier KT, Pan YA, Lapan SW, Göz Aytürk D, Berezovskii VK, Wark AR, Drokhlyansky E, Bielecki J, Born RT, Schier AF, Cepko CL. Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms. J Comp Neurol. 2015 Aug 01; 523(11):1639-63. PMID: 25688551.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  23. Xiong W, MacColl Garfinkel AE, Li Y, Benowitz LI, Cepko CL. NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. J Clin Invest. 2015 Apr; 125(4):1433-45. PMID: 25798616; PMCID: PMC4396467.
    Citations: 39     Fields:    Translation:AnimalsCells
  24. Wang S, Sengel C, Emerson MM, Cepko CL. A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina. Dev Cell. 2014 Sep 08; 30(5):513-27. PMID: 25155555; PMCID: PMC4304698.
    Citations: 37     Fields:    Translation:AnimalsCells
  25. Cepko C. Intrinsically different retinal progenitor cells produce specific types of progeny. Nat Rev Neurosci. 2014 Sep; 15(9):615-27. PMID: 25096185.
    Citations: 55     Fields:    Translation:AnimalsCells
  26. Sukhdeo K, Koch CE, Miller TE, Zhou H, Rivera M, Yan K, Cepko CL, Lathia JD, Rich JN. The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina. Exp Eye Res. 2014 Feb; 119:106-10. PMID: 24246263.
    Citations: 7     Fields:    Translation:AnimalsCells
  27. Mizeracka K, Trimarchi JM, Stadler MB, Cepko CL. Analysis of gene expression in wild-type and Notch1 mutant retinal cells by single cell profiling. Dev Dyn. 2013 Oct; 242(10):1147-59. PMID: 23813500; PMCID: PMC3882027.
    Citations: 7     Fields:    Translation:AnimalsCells
  28. Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B, Cepko CL. A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell. 2013 Aug 15; 154(4):928-39. PMID: 23953120; PMCID: PMC4096992.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  29. Jiang H, Wang L, Beier KT, Cepko CL, Fekete DM, Brigande JV. Lineage analysis of the late otocyst stage mouse inner ear by transuterine microinjection of a retroviral vector encoding alkaline phosphatase and an oligonucleotide library. PLoS One. 2013; 8(7):e69314. PMID: 23935981.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  30. Emerson MM, Surzenko N, Goetz JJ, Trimarchi J, Cepko CL. Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors. Dev Cell. 2013 Jul 15; 26(1):59-72. PMID: 23867227; PMCID: PMC3819454.
    Citations: 25     Fields:    Translation:AnimalsCells
  31. Mizeracka K, DeMaso CR, Cepko CL. Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate. Development. 2013 Aug; 140(15):3188-97. PMID: 23824579; PMCID: PMC3931735.
    Citations: 17     Fields:    Translation:AnimalsCells
  32. Cepko CL, Vandenberghe LH. Retinal gene therapy coming of age. Hum Gene Ther. 2013 Mar; 24(3):242-4. PMID: 23458444; PMCID: PMC4530353.
    Citations: 14     Fields:    
  33. Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo. Front Neural Circuits. 2013; 7:11. PMID: 23403489; PMCID: PMC3566411.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  34. Whited JL, Tsai SL, Beier KT, White JN, Piekarski N, Hanken J, Cepko CL, Tabin CJ. Pseudotyped retroviruses for infecting axolotl in vivo and in vitro. Development. 2013 Mar; 140(5):1137-46. PMID: 23344705.
    Citations: 12     Fields:    Translation:AnimalsCells
  35. Beier KT, Borghuis BG, El-Danaf RN, Huberman AD, Demb JB, Cepko CL. Transsynaptic tracing with vesicular stomatitis virus reveals novel retinal circuitry. J Neurosci. 2013 Jan 02; 33(1):35-51. PMID: 23283320; PMCID: PMC3711516.
    Citations: 22     Fields:    Translation:AnimalsCells
  36. Beier K, Cepko C. Viral tracing of genetically defined neural circuitry. J Vis Exp. 2012 Oct 17; (68). PMID: 23117695; PMCID: PMC3490305.
    Citations: 1     Fields:    Translation:AnimalsCells
  37. Cepko CL. Emerging gene therapies for retinal degenerations. J Neurosci. 2012 May 09; 32(19):6415-20. PMID: 22573664; PMCID: PMC3392151.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  38. Roesch K, Stadler MB, Cepko CL. Gene expression changes within Müller glial cells in retinitis pigmentosa. Mol Vis. 2012; 18:1197-214. PMID: 22665967; PMCID: PMC3365136.
    Citations: 24     Fields:    Translation:AnimalsCells
  39. Hafler BP, Surzenko N, Beier KT, Punzo C, Trimarchi JM, Kong JH, Cepko CL. Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7882-7. PMID: 22543161; PMCID: PMC3356608.
    Citations: 36     Fields:    Translation:AnimalsCells
  40. Punzo C, Xiong W, Cepko CL. Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame? J Biol Chem. 2012 Jan 13; 287(3):1642-8. PMID: 22074929; PMCID: PMC3265845.
    Citations: 39     Fields:    Translation:HumansAnimals
  41. Emerson MM, Cepko CL. Identification of a retina-specific Otx2 enhancer element active in immature developing photoreceptors. Dev Biol. 2011 Dec 01; 360(1):241-55. PMID: 21963459; PMCID: PMC3339761.
    Citations: 15     Fields:    Translation:AnimalsCells
  42. Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith LE, Siemann DW, Kladde MP, Cepko CL, Lu J. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6. PMID: 21896759; PMCID: PMC3174592.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  43. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15414-9. PMID: 21825165; PMCID: PMC3174680.
    Citations: 50     Fields:    Translation:AnimalsCells
  44. Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011 Jul 29; 18(7):833-8. PMID: 21802004.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  45. Cherry TJ, Wang S, Bormuth I, Schwab M, Olson J, Cepko CL. NeuroD factors regulate cell fate and neurite stratification in the developing retina. J Neurosci. 2011 May 18; 31(20):7365-79. PMID: 21593321; PMCID: PMC3135085.
    Citations: 23     Fields:    Translation:AnimalsCells
  46. Beier KT, Samson ME, Matsuda T, Cepko CL. Conditional expression of the TVA receptor allows clonal analysis of descendents from Cre-expressing progenitor cells. Dev Biol. 2011 May 15; 353(2):309-20. PMID: 21397594; PMCID: PMC3100772.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  47. Huynh MA, Ikeuchi Y, Netherton S, de la Torre-Ubieta L, Kanadia R, Stegmüller J, Cepko C, Bonni S, Bonni A. An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. 2011 Mar 10; 69(5):930-44. PMID: 21382553; PMCID: PMC3073069.
    Citations: 15     Fields:    Translation:AnimalsCells
  48. Billings NA, Emerson MM, Cepko CL. Analysis of thyroid response element activity during retinal development. PLoS One. 2010 Oct 29; 5(10):e13739. PMID: 21060789; PMCID: PMC2966421.
    Citations: 6     Fields:    Translation:HumansCells
  49. Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR. Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein. ACS Chem Biol. 2010 Aug 20; 5(8):747-52. PMID: 20545362.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  50. Cepko C. Neuroscience. Seeing the light of day. Science. 2010 Jul 23; 329(5990):403-4. PMID: 20651144.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  51. Rompani SB, Cepko CL. A common progenitor for retinal astrocytes and oligodendrocytes. J Neurosci. 2010 Apr 07; 30(14):4970-80. PMID: 20371817; PMCID: PMC3536471.
    Citations: 19     Fields:    Translation:AnimalsCells
  52. Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature. 2010 Jan 21; 463(7279):374-8. PMID: 20090754; PMCID: PMC2943587.
    Citations: 101     Fields:    Translation:AnimalsCells
  53. Kanadia RN, Cepko CL. Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development. Genes Dev. 2010 Feb 01; 24(3):229-34. PMID: 20080942; PMCID: PMC2811824.
    Citations: 6     Fields:    Translation:AnimalsCells
  54. Samson M, Emerson MM, Cepko CL. Robust marking of photoreceptor cells and pinealocytes with several reporters under control of the Crx gene. Dev Dyn. 2009 Dec; 238(12):3218-25. PMID: 19882727; PMCID: PMC2965029.
    Citations: 10     Fields:    Translation:AnimalsCells
  55. Trimarchi JM, Cho SH, Cepko CL. Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. Dev Dyn. 2009 Sep; 238(9):2327-9. PMID: 19449303; PMCID: PMC2916742.
    Citations: 21     Fields:    Translation:Animals
  56. Cherry TJ, Trimarchi JM, Stadler MB, Cepko CL. Development and diversification of retinal amacrine interneurons at single cell resolution. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9495-500. PMID: 19470466; PMCID: PMC2686638.
    Citations: 41     Fields:    Translation:AnimalsCells
  57. Jadhav AP, Roesch K, Cepko CL. Development and neurogenic potential of Müller glial cells in the vertebrate retina. Prog Retin Eye Res. 2009 Jul; 28(4):249-62. PMID: 19465144; PMCID: PMC3233204.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  58. Dyer MA, Martins R, da Silva Filho M, Muniz JA, Silveira LC, Cepko CL, Finlay BL. Developmental sources of conservation and variation in the evolution of the primate eye. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8963-8. PMID: 19451636; PMCID: PMC2690025.
    Citations: 24     Fields:    Translation:AnimalsCells
  59. Chen B, Cepko CL. HDAC4 regulates neuronal survival in normal and diseased retinas. Science. 2009 Jan 09; 323(5911):256-9. PMID: 19131628; PMCID: PMC3339762.
    Citations: 74     Fields:    Translation:AnimalsCells
  60. Punzo C, Kornacker K, Cepko CL. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci. 2009 Jan; 12(1):44-52. PMID: 19060896; PMCID: PMC3339764.
    Citations: 147     Fields:    Translation:AnimalsCells
  61. Kanadia RN, Clark VE, Punzo C, Trimarchi JM, Cepko CL. Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons. Development. 2008 Dec; 135(23):3923-33. PMID: 18987029; PMCID: PMC3593640.
    Citations: 8     Fields:    Translation:AnimalsCells
  62. Trimarchi JM, Harpavat S, Billings NA, Cepko CL. Thyroid hormone components are expressed in three sequential waves during development of the chick retina. BMC Dev Biol. 2008 Oct 14; 8:101. PMID: 18854032; PMCID: PMC2579430.
    Citations: 20     Fields:    Translation:AnimalsCells
  63. Kim DS, Matsuda T, Cepko CL. A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression. J Neurosci. 2008 Jul 30; 28(31):7748-64. PMID: 18667607; PMCID: PMC2714707.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  64. Roesch K, Jadhav AP, Trimarchi JM, Stadler MB, Roska B, Sun BB, Cepko CL. The transcriptome of retinal Müller glial cells. J Comp Neurol. 2008 Jul 10; 509(2):225-38. PMID: 18465787; PMCID: PMC2665263.
    Citations: 108     Fields:    Translation:AnimalsCells
  65. Nygaard V, Liu F, Holden M, Kuo WP, Trimarchi J, Ohno-Machado L, Cepko CL, Frigessi A, Glad IK, Wiel MA, Hovig E, Lyng H. Validation of oligoarrays for quantitative exploration of the transcriptome. BMC Genomics. 2008 May 30; 9:258. PMID: 18513391; PMCID: PMC2430212.
    Citations: 2     Fields:    Translation:Animals
  66. Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008 May 07; 28(19):4878-87. PMID: 18463241; PMCID: PMC3325486.
    Citations: 97     Fields:    Translation:Animals
  67. Lagali PS, Balya D, Awatramani GB, Münch TA, Kim DS, Busskamp V, Cepko CL, Roska B. Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci. 2008 Jun; 11(6):667-75. PMID: 18432197.
    Citations: 161     Fields:    Translation:AnimalsCells
  68. Kim DS, Ross SE, Trimarchi JM, Aach J, Greenberg ME, Cepko CL. Identification of molecular markers of bipolar cells in the murine retina. J Comp Neurol. 2008 Apr 10; 507(5):1795-810. PMID: 18260140; PMCID: PMC2665264.
    Citations: 54     Fields:    Translation:AnimalsCells
  69. Punzo C, Cepko CL. Ultrasound-guided in utero injections allow studies of the development and function of the eye. Dev Dyn. 2008 Apr; 237(4):1034-42. PMID: 18351670; PMCID: PMC2532702.
    Citations: 16     Fields:    Translation:Animals
  70. Trimarchi JM, Stadler MB, Cepko CL. Individual retinal progenitor cells display extensive heterogeneity of gene expression. PLoS One. 2008 Feb 13; 3(2):e1588. PMID: 18270576; PMCID: PMC2220035.
    Citations: 69     Fields:    Translation:AnimalsCells
  71. Morrow EM, Chen CM, Cepko CL. Temporal order of bipolar cell genesis in the neural retina. Neural Dev. 2008 Jan 23; 3:2. PMID: 18215319; PMCID: PMC2248187.
    Citations: 26     Fields:    Translation:AnimalsCells
  72. Matsuda T, Cepko CL. Analysis of gene function in the retina. Methods Mol Biol. 2008; 423:259-78. PMID: 18370205.
    Citations: 10     Fields:    Translation:Animals
  73. Rompani SB, Cepko CL. Retinal progenitor cells can produce restricted subsets of horizontal cells. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):192-7. PMID: 18162542; PMCID: PMC2224184.
    Citations: 26     Fields:    Translation:AnimalsCells
  74. Hsiau TH, Diaconu C, Myers CA, Lee J, Cepko CL, Corbo JC. The cis-regulatory logic of the mammalian photoreceptor transcriptional network. PLoS One. 2007 Jul 25; 2(7):e643. PMID: 17653270; PMCID: PMC1916400.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  75. Corbo JC, Myers CA, Lawrence KA, Jadhav AP, Cepko CL. A typology of photoreceptor gene expression patterns in the mouse. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12069-74. PMID: 17620597; PMCID: PMC1913549.
    Citations: 41     Fields:    Translation:AnimalsCells
  76. Chen B, Cepko CL. Requirement of histone deacetylase activity for the expression of critical photoreceptor genes. BMC Dev Biol. 2007 Jun 29; 7:78. PMID: 17603891; PMCID: PMC1914050.
    Citations: 25     Fields:    Translation:AnimalsCells
  77. Trimarchi JM, Stadler MB, Roska B, Billings N, Sun B, Bartch B, Cepko CL. Molecular heterogeneity of developing retinal ganglion and amacrine cells revealed through single cell gene expression profiling. J Comp Neurol. 2007 Jun 20; 502(6):1047-65. PMID: 17444492.
    Citations: 78     Fields:    Translation:AnimalsCells
  78. Liu F, Jenssen TK, Trimarchi J, Punzo C, Cepko CL, Ohno-Machado L, Hovig E, Kuo WP. Comparison of hybridization-based and sequencing-based gene expression technologies on biological replicates. BMC Genomics. 2007 Jun 07; 8:153. PMID: 17555589; PMCID: PMC1899500.
    Citations: 32     Fields:    Translation:AnimalsCells
  79. Viney TJ, Balint K, Hillier D, Siegert S, Boldogkoi Z, Enquist LW, Meister M, Cepko CL, Roska B. Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing. Curr Biol. 2007 Jun 05; 17(11):981-8. PMID: 17524644.
    Citations: 76     Fields:    Translation:AnimalsCells
  80. Galante PA, Trimarchi J, Cepko CL, de Souza SJ, Ohno-Machado L, Kuo WP. Automatic correspondence of tags and genes (ACTG): a tool for the analysis of SAGE, MPSS and SBS data. Bioinformatics. 2007 Apr 01; 23(7):903-5. PMID: 17277333.
    Citations: 6     Fields:    
  81. Punzo C, Cepko C. Cellular responses to photoreceptor death in the rd1 mouse model of retinal degeneration. Invest Ophthalmol Vis Sci. 2007 Feb; 48(2):849-57. PMID: 17251487.
    Citations: 28     Fields:    Translation:AnimalsCells
  82. Matsuda T, Cepko CL. Controlled expression of transgenes introduced by in vivo electroporation. Proc Natl Acad Sci U S A. 2007 Jan 16; 104(3):1027-32. PMID: 17209010; PMCID: PMC1764220.
    Citations: 203     Fields:    Translation:HumansAnimalsCells
  83. Jadhav AP, Cho SH, Cepko CL. Notch activity permits retinal cells to progress through multiple progenitor states and acquire a stem cell property. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):18998-9003. PMID: 17148603; PMCID: PMC1682012.
    Citations: 54     Fields:    Translation:AnimalsCells
  84. Young-Pearse TL, Ivic L, Kriegstein AR, Cepko CL. Characterization of mice with targeted deletion of glycine receptor alpha 2. Mol Cell Biol. 2006 Aug; 26(15):5728-34. PMID: 16847326; PMCID: PMC1592777.
    Citations: 26     Fields:    Translation:Animals
  85. Cho SH, Cepko CL. Wnt2b/beta-catenin-mediated canonical Wnt signaling determines the peripheral fates of the chick eye. Development. 2006 Aug; 133(16):3167-77. PMID: 16854977.
    Citations: 60     Fields:    Translation:AnimalsCells
  86. Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK. A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol. 2006 Jul; 24(7):832-40. PMID: 16823376.
    Citations: 63     Fields:    
  87. Wildner H, Müller T, Cho SH, Bröhl D, Cepko CL, Guillemot F, Birchmeier C. dILA neurons in the dorsal spinal cord are the product of terminal and non-terminal asymmetric progenitor cell divisions, and require Mash1 for their development. Development. 2006 Jun; 133(11):2105-13. PMID: 16690754.
    Citations: 39     Fields:    Translation:AnimalsCells
  88. Jadhav AP, Mason HA, Cepko CL. Notch 1 inhibits photoreceptor production in the developing mammalian retina. Development. 2006 Mar; 133(5):913-23. PMID: 16452096.
    Citations: 79     Fields:    Translation:AnimalsCells
  89. Harpavat S, Cepko CL. RCAS-RNAi: a loss-of-function method for the developing chick retina. BMC Dev Biol. 2006 Jan 22; 6:2. PMID: 16426460; PMCID: PMC1402266.
    Citations: 16     Fields:    Translation:AnimalsCells
  90. Cepko CL. Effect of gene expression on cone survival in retinitis pigmentosa. Retina. 2005 Dec; 25(8 Suppl):S21-S24. PMID: 16374320.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  91. Sen J, Harpavat S, Peters MA, Cepko CL. Retinoic acid regulates the expression of dorsoventral topographic guidance molecules in the chick retina. Development. 2005 Dec; 132(23):5147-59. PMID: 16251210.
    Citations: 14     Fields:    Translation:Animals
  92. Corbo JC, Cepko CL. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. PLoS Genet. 2005 Aug; 1(2):e11. PMID: 16110338; PMCID: PMC1186732.
    Citations: 68     Fields:    Translation:AnimalsCells
  93. Rowan S, Cepko CL. A POU factor binding site upstream of the Chx10 homeobox gene is required for Chx10 expression in subsets of retinal progenitor cells and bipolar cells. Dev Biol. 2005 May 15; 281(2):240-55. PMID: 15893976.
    Citations: 14     Fields:    Translation:AnimalsCells
  94. Young TL, Matsuda T, Cepko CL. The noncoding RNA taurine upregulated gene 1 is required for differentiation of the murine retina. Curr Biol. 2005 Mar 29; 15(6):501-12. PMID: 15797018.
    Citations: 120     Fields:    Translation:AnimalsCells
  95. Schulte D, Peters MA, Sen J, Cepko CL. The rod photoreceptor pattern is set at the optic vesicle stage and requires spatially restricted cVax expression. J Neurosci. 2005 Mar 16; 25(11):2823-31. PMID: 15772342.
    Citations: 3     Fields:    Translation:AnimalsCells
  96. Morrow EM, Furukawa T, Raviola E, Cepko CL. Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice. BMC Neurosci. 2005 Jan 27; 6:5. PMID: 15676071; PMCID: PMC548520.
    Citations: 21     Fields:    Translation:AnimalsCells
  97. Kim JS, Coon SL, Blackshaw S, Cepko CL, Møller M, Mukda S, Zhao WQ, Charlton CG, Klein DC. Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. J Biol Chem. 2005 Jan 07; 280(1):677-84. PMID: 15504733.
    Citations: 11     Fields:    Translation:Animals
  98. Rowan S, Chen CM, Young TL, Fisher DE, Cepko CL. Transdifferentiation of the retina into pigmented cells in ocular retardation mice defines a new function of the homeodomain gene Chx10. Development. 2004 Oct; 131(20):5139-52. PMID: 15459106.
    Citations: 50     Fields:    Translation:Animals
  99. Rowan S, Cepko CL. Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter. Dev Biol. 2004 Jul 15; 271(2):388-402. PMID: 15223342.
    Citations: 108     Fields:    Translation:AnimalsCells
  100. Blackshaw S, Harpavat S, Trimarchi J, Cai L, Huang H, Kuo WP, Weber G, Lee K, Fraioli RE, Cho SH, Yung R, Asch E, Ohno-Machado L, Wong WH, Cepko CL. Genomic analysis of mouse retinal development. PLoS Biol. 2004 Sep; 2(9):E247. PMID: 15226823; PMCID: PMC439783.
    Citations: 229     Fields:    Translation:AnimalsCells
  101. Cai L, Huang H, Blackshaw S, Liu JS, Cepko C, Wong WH. Clustering analysis of SAGE data using a Poisson approach. Genome Biol. 2004; 5(7):R51. PMID: 15239836; PMCID: PMC463327.
    Citations: 27     Fields:    Translation:Animals
  102. Young TL, Cepko CL. A role for ligand-gated ion channels in rod photoreceptor development. Neuron. 2004 Mar 25; 41(6):867-79. PMID: 15046720.
    Citations: 44     Fields:    Translation:AnimalsCells
  103. Zhang J, Gray J, Wu L, Leone G, Rowan S, Cepko CL, Zhu X, Craft CM, Dyer MA. Rb regulates proliferation and rod photoreceptor development in the mouse retina. Nat Genet. 2004 Apr; 36(4):351-60. PMID: 14991054.
    Citations: 60     Fields:    Translation:AnimalsCells
  104. Pignatelli V, Cepko CL, Strettoi E. Inner retinal abnormalities in a mouse model of Leber's congenital amaurosis. J Comp Neurol. 2004 Feb 09; 469(3):351-9. PMID: 14730587.
    Citations: 24     Fields:    Translation:AnimalsCells
  105. Livesey FJ, Young TL, Cepko CL. An analysis of the gene expression program of mammalian neural progenitor cells. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1374-9. PMID: 14734810; PMCID: PMC337060.
    Citations: 26     Fields:    Translation:AnimalsCells
  106. Matsuda T, Cepko CL. Electroporation and RNA interference in the rodent retina in vivo and in vitro. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):16-22. PMID: 14603031; PMCID: PMC314130.
    Citations: 296     Fields:    Translation:AnimalsCells
  107. Harpavat S, Cepko CL. Thyroid hormone and retinal development: an emerging field. Thyroid. 2003 Nov; 13(11):1013-9. PMID: 14651785.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  108. Dyer MA, Livesey FJ, Cepko CL, Oliver G. Prox1 function controls progenitor cell proliferation and horizontal cell genesis in the mammalian retina. Nat Genet. 2003 May; 34(1):53-8. PMID: 12692551.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  109. Jin Z, Zhang J, Klar A, Chédotal A, Rao Y, Cepko CL, Bao ZZ. Irx4-mediated regulation of Slit1 expression contributes to the definition of early axonal paths inside the retina. Development. 2003 Mar; 130(6):1037-48. PMID: 12571096.
    Citations: 14     Fields:    Translation:AnimalsCells
  110. Blackshaw S, Kuo WP, Park PJ, Tsujikawa M, Gunnersen JM, Scott HS, Boon WM, Tan SS, Cepko CL. MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues. Genome Biol. 2003; 4(3):R17. PMID: 12620102; PMCID: PMC153457.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  111. Blackshaw S, Cepko CL. Stem cells that know their place. Nat Neurosci. 2002 Dec; 5(12):1251-2. PMID: 12447376.
    Citations:    Fields:    Translation:HumansAnimalsCells
  112. Chen CM, Cepko CL. The chicken RaxL gene plays a role in the initiation of photoreceptor differentiation. Development. 2002 Dec; 129(23):5363-75. PMID: 12403708.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  113. Peters MA, Cepko CL. The dorsal-ventral axis of the neural retina is divided into multiple domains of restricted gene expression which exhibit features of lineage compartments. Dev Biol. 2002 Nov 01; 251(1):59-73. PMID: 12413898.
    Citations: 15     Fields:    Translation:Animals
  114. Goh KL, Cai L, Cepko CL, Gertler FB. Ena/VASP proteins regulate cortical neuronal positioning. Curr Biol. 2002 Apr 02; 12(7):565-9. PMID: 11937025.
    Citations: 28     Fields:    Translation:AnimalsCells
  115. Furukawa A, Koike C, Lippincott P, Cepko CL, Furukawa T. The mouse Crx 5'-upstream transgene sequence directs cell-specific and developmentally regulated expression in retinal photoreceptor cells. J Neurosci. 2002 Mar 01; 22(5):1640-7. PMID: 11880494.
    Citations: 33     Fields:    Translation:AnimalsCells
  116. Bowne SJ, Sullivan LS, Blanton SH, Cepko CL, Blackshaw S, Birch DG, Hughbanks-Wheaton D, Heckenlively JR, Daiger SP. Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. Hum Mol Genet. 2002 Mar 01; 11(5):559-68. PMID: 11875050; PMCID: PMC2585828.
    Citations: 58     Fields:    Translation:HumansCells
  117. Szele FG, Chin HK, Rowlson MA, Cepko CL. Sox-9 and cDachsund-2 expression in the developing chick telencephalon. Mech Dev. 2002 Mar; 112(1-2):179-82. PMID: 11850191.
    Citations: 3     Fields:    Translation:Animals
  118. Sharon D, Blackshaw S, Cepko CL, Dryja TP. Profile of the genes expressed in the human peripheral retina, macula, and retinal pigment epithelium determined through serial analysis of gene expression (SAGE). Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):315-20. PMID: 11756676; PMCID: PMC117558.
    Citations: 48     Fields:    Translation:HumansCells
  119. Blackshaw S, Fraioli RE, Furukawa T, Cepko CL. Comprehensive analysis of photoreceptor gene expression and the identification of candidate retinal disease genes. Cell. 2001 Nov 30; 107(5):579-89. PMID: 11733058.
    Citations: 115     Fields:    Translation:HumansAnimalsCells
  120. Chang B, Smith RS, Peters M, Savinova OV, Hawes NL, Zabaleta A, Nusinowitz S, Martin JE, Davisson ML, Cepko CL, Hogan BL, John SW. Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. BMC Genet. 2001; 2:18. PMID: 11722794; PMCID: PMC59999.
    Citations: 40     Fields:    Translation:Animals
  121. Cepko CL. Tackling the brain's genetic complexity. Nat Neurosci. 2001 Nov; 4 Suppl:1159-60. PMID: 11687824.
    Citations:    Fields:    Translation:HumansAnimals
  122. Livesey R, Cepko C. Neurobiology. Developing order. Nature. 2001 Oct 04; 413(6855):471, 473. PMID: 11586341.
    Citations: 6     Fields:    Translation:AnimalsCells
  123. Lu QR, Cai L, Rowitch D, Cepko CL, Stiles CD. Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci. 2001 Oct; 4(10):973-4. PMID: 11574831.
    Citations: 35     Fields:    Translation:AnimalsCells
  124. Dyer MA, Cepko CL. p27Kip1 and p57Kip2 regulate proliferation in distinct retinal progenitor cell populations. J Neurosci. 2001 Jun 15; 21(12):4259-71. PMID: 11404411.
    Citations: 67     Fields:    Translation:AnimalsCells
  125. Cepko C, Pear W. Overview of the retrovirus transduction system. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.9. PMID: 18265289.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  126. Cepko C. Large-scale preparation and concentration of retrovirus stocks. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.12. PMID: 18265280.
    Citations: 5     Fields:    Translation:AnimalsCells
  127. Cepko C, Pear W. Retrovirus infection of cells in vitro and in vivo. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.14. PMID: 18265282.
    Citations: 6     Fields:    Translation:AnimalsCells
  128. Cepko C, Pear W. Detection of helper virus in retrovirus stocks. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.13. PMID: 18265281.
    Citations: 1     Fields:    Translation:AnimalsCells
  129. Dyer MA, Cepko CL. Regulating proliferation during retinal development. Nat Rev Neurosci. 2001 May; 2(5):333-42. PMID: 11331917.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  130. Cepko C. Preparation of a specific retrovirus producer cell line. Curr Protoc Mol Biol. 2001 May; Chapter 9:Unit9.10. PMID: 18265278.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  131. Bruneau BG, Bao ZZ, Fatkin D, Xavier-Neto J, Georgakopoulos D, Maguire CT, Berul CI, Kass DA, Kuroski-de Bold ML, de Bold AJ, Conner DA, Rosenthal N, Cepko CL, Seidman CE, Seidman JG. Cardiomyopathy in Irx4-deficient mice is preceded by abnormal ventricular gene expression. Mol Cell Biol. 2001 Mar; 21(5):1730-6. PMID: 11238910; PMCID: PMC86719.
    Citations: 37     Fields:    Translation:AnimalsCells
  132. Livesey FJ, Cepko CL. Vertebrate neural cell-fate determination: lessons from the retina. Nat Rev Neurosci. 2001 Feb; 2(2):109-18. PMID: 11252990.
    Citations: 282     Fields:    Translation:HumansAnimalsCells
  133. Dyer MA, Cepko CL. The p57Kip2 cyclin kinase inhibitor is expressed by a restricted set of amacrine cells in the rodent retina. J Comp Neurol. 2001 Jan 22; 429(4):601-14. PMID: 11135238.
    Citations: 15     Fields:    Translation:AnimalsCells
  134. Lin JC, Cai L, Cepko CL. The external granule layer of the developing chick cerebellum generates granule cells and cells of the isthmus and rostral hindbrain. J Neurosci. 2001 Jan 01; 21(1):159-68. PMID: 11150332.
    Citations: 17     Fields:    Translation:AnimalsCells
  135. Cepko CL. Genomics approaches to photoreceptor development and disease. Harvey Lect. 2001-2002; 97:85-110. PMID: 14562518.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  136. Schulte D, Cepko CL. Two homeobox genes define the domain of EphA3 expression in the developing chick retina. Development. 2000 Dec; 127(23):5033-45. PMID: 11060230.
    Citations: 14     Fields:    Translation:AnimalsCells
  137. Dyer MA, Cepko CL. Control of Müller glial cell proliferation and activation following retinal injury. Nat Neurosci. 2000 Sep; 3(9):873-80. PMID: 10966617.
    Citations: 127     Fields:    Translation:AnimalsCells
  138. Dyer MA, Cepko CL. p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina. Development. 2000 Aug; 127(16):3593-605. PMID: 10903183.
    Citations: 48     Fields:    Translation:AnimalsCells
  139. Liu W, Khare SL, Liang X, Peters MA, Liu X, Cepko CL, Xiang M. All Brn3 genes can promote retinal ganglion cell differentiation in the chick. Development. 2000 Aug; 127(15):3237-47. PMID: 10887080.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  140. Cai L, Morrow EM, Cepko CL. Misexpression of basic helix-loop-helix genes in the murine cerebral cortex affects cell fate choices and neuronal survival. Development. 2000 Jul; 127(14):3021-30. PMID: 10862740.
    Citations: 43     Fields:    Translation:AnimalsCells
  141. Furukawa T, Mukherjee S, Bao ZZ, Morrow EM, Cepko CL. rax, Hes1, and notch1 promote the formation of Müller glia by postnatal retinal progenitor cells. Neuron. 2000 May; 26(2):383-94. PMID: 10839357.
    Citations: 115     Fields:    Translation:AnimalsCells
  142. Livesey FJ, Furukawa T, Steffen MA, Church GM, Cepko CL. Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx. Curr Biol. 2000 Mar 23; 10(6):301-10. PMID: 10744971.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  143. Belliveau MJ, Young TL, Cepko CL. Late retinal progenitor cells show intrinsic limitations in the production of cell types and the kinetics of opsin synthesis. J Neurosci. 2000 Mar 15; 20(6):2247-54. PMID: 10704500.
    Citations: 31     Fields:    Translation:AnimalsCells