Harvard Catalyst Profiles

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Constance Cepko, Ph.D.

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Institution
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Mentoring
Deciphering the Role of Alternative Splicing Factors Cugbp2 and Sfrs6 in Retinal Development
Summer, 06/11/07 - 08/17/07

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY029348 (CEPKO, CONSTANCE L) Apr 1, 2019 - Mar 31, 2024
    NIH
    AAV Induced Toxicity in the Eye
    Role: Principal Investigator
  2. R01EY029771 (CEPKO, CONSTANCE L) Jan 1, 2019 - Dec 31, 2023
    NIH
    Determination of Cone Photoreceptor Fate
    Role: Principal Investigator
  3. R21AG059157 (CEPKO, CONSTANCE L) Aug 15, 2018 - Apr 30, 2021
    NIH
    Gene Therapy for Alzheimer's Disease
    Role: Principal Investigator
  4. U01NS090449 (ENGERT, FLORIAN) Sep 30, 2014 - Jul 31, 2018
    NIH
    Neural circuits in zebrafish: form, function and plasticity
    Role: Principal Investigator
  5. R01NS083848 (CEPKO, CONSTANCE L) Jul 1, 2013 - Apr 30, 2019
    NIH
    Development of novel transsynaptic tracers for use in the central nervous system
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dingus JG, Tang JCY, Amamoto R, Wallick GK, Cepko CL. A general approach for stabilizing nanobodies for intracellular expression. Elife. 2022 11 23; 11. PMID: 36416528; PMCID: PMC9683787.
    Citations:    Fields:    
  2. Kishi JY, Liu N, West ER, Sheng K, Jordanides JJ, Serrata M, Cepko CL, Saka SK, Yin P. Light-Seq: light-directed in situ barcoding of biomolecules in fixed cells and tissues for spatially indexed sequencing. Nat Methods. 2022 11; 19(11):1393-1402. PMID: 36216958; PMCID: PMC9636025.
    Citations:    Fields:    Translation:Animals
  3. Amamoto R, Wallick GK, Cepko CL. Retinoic acid signaling mediates peripheral cone photoreceptor survival in a mouse model of retina degeneration. Elife. 2022 03 22; 11. PMID: 35315776; PMCID: PMC8940176.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. Wang SK, Cepko CL. Targeting Microglia to Treat Degenerative Eye Diseases. Front Immunol. 2022; 13:843558. PMID: 35251042; PMCID: PMC8891158.
    Citations:    Fields:    Translation:AnimalsCells
  5. Göz Aytürk D, You W, Cepko CL. Mouse Lines with Cre-Mediated Recombination in Retinal Amacrine Cells. eNeuro. 2022 Jan-Feb; 9(1). PMID: 35045975; PMCID: PMC8856716.
    Citations:    Fields:    Translation:AnimalsCells
  6. West ER, Lapan SW, Lee C, Kajderowicz KM, Li X, Cepko CL. Spatiotemporal patterns of neuronal subtype genesis suggest hierarchical development of retinal diversity. Cell Rep. 2022 01 04; 38(1):110191. PMID: 34986354.
    Citations:    Fields:    Translation:AnimalsCells
  7. West ER, Cepko CL. Development and diversification of bipolar interneurons in the mammalian retina. Dev Biol. 2022 01; 481:30-42. PMID: 34534525.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Wang SK, Xue Y, Cepko CL. Augmentation of CD47/SIRPa signaling protects cones in genetic models of retinal degeneration. JCI Insight. 2021 08 23; 6(16). PMID: 34197341; PMCID: PMC8409989.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Xue Y, Wang SK, Rana P, West ER, Hong CM, Feng H, Wu DM, Cepko CL. AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa. Elife. 2021 04 13; 10. PMID: 33847261; PMCID: PMC8081528.
    Citations: 3     Fields:    Translation:AnimalsCells
  10. Chan YK, Wang SK, Chu CJ, Copland DA, Letizia AJ, Costa Verdera H, Chiang JJ, Sethi M, Wang MK, Neidermyer WJ, Chan Y, Lim ET, Graveline AR, Sanchez M, Boyd RF, Vihtelic TS, Inciong RGCO, Slain JM, Alphonse PJ, Xue Y, Robinson-McCarthy LR, Tam JM, Jabbar MH, Sahu B, Adeniran JF, Muhuri M, Tai PWL, Xie J, Krause TB, Vernet A, Pezone M, Xiao R, Liu T, Wang W, Kaplan HJ, Gao G, Dick AD, Mingozzi F, McCall MA, Cepko CL, Church GM. Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses. Sci Transl Med. 2021 02 10; 13(580). PMID: 33568518; PMCID: PMC8409505.
    Citations: 31     Fields:    Translation:AnimalsCells
  11. Wu DM, Ji X, Ivanchenko MV, Chung M, Piper M, Rana P, Wang SK, Xue Y, West E, Zhao SR, Xu H, Cicconet M, Xiong W, Cepko CL. Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa. JCI Insight. 2021 01 25; 6(2). PMID: 33491671; PMCID: PMC7934854.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  12. Anahtar MN, McGrath GEG, Rabe BA, Tanner NA, White BA, Lennerz JKM, Branda JA, Cepko CL, Rosenberg ES. Clinical Assessment and Validation of a Rapid and Sensitive SARS-CoV-2 Test Using Reverse Transcription Loop-Mediated Isothermal Amplification Without the Need for RNA Extraction. Open Forum Infect Dis. 2021 Feb; 8(2):ofaa631. PMID: 34853795; PMCID: PMC7798487.
    Citations: 10     
  13. Wang SK, Lapan SW, Hong CM, Krause TB, Cepko CL. In Situ Detection of Adeno-associated Viral Vector Genomes with SABER-FISH. Mol Ther Methods Clin Dev. 2020 Dec 11; 19:376-386. PMID: 33209963.
    Citations: 7     
  14. Amamoto R, Garcia MD, West ER, Choi J, Lapan SW, Lane EA, Perrimon N, Cepko CL. Probe-Seq: Method for RNA Sequencing of Specific Cell Types from Animal Tissue. Bio Protoc. 2020 Sep 20; 10(18):e3749. PMID: 33659409; PMCID: PMC7842722.
    Citations:    
  15. Rabe BA, Cepko C. SARS-CoV-2 detection using isothermal amplification and a rapid, inexpensive protocol for sample inactivation and purification. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24450-24458. PMID: 32900935; PMCID: PMC7533677.
    Citations: 96     Fields:    Translation:HumansCellsPHPublic Health
  16. Wang SK, Xue Y, Cepko CL. Microglia modulation by TGF-ß1 protects cones in mouse models of retinal degeneration. J Clin Invest. 2020 08 03; 130(8):4360-4369. PMID: 32352930; PMCID: PMC7410072.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  17. Chan CSY, Lonfat N, Zhao R, Davis AE, Li L, Wu MR, Lin CH, Ji Z, Cepko CL, Wang S. Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina. Development. 2020 07 26; 147(14). PMID: 32631829; PMCID: PMC7406324.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  18. Luo L, Ambrozkiewicz MC, Benseler F, Chen C, Dumontier E, Falkner S, Furlanis E, Gomez AM, Hoshina N, Huang WH, Hutchison MA, Itoh-Maruoka Y, Lavery LA, Li W, Maruo T, Motohashi J, Pai EL, Pelkey KA, Pereira A, Philips T, Sinclair JL, Stogsdill JA, Traunmüller L, Wang J, Wortel J, You W, Abumaria N, Beier KT, Brose N, Burgess HA, Cepko CL, Cloutier JF, Eroglu C, Goebbels S, Kaeser PS, Kay JN, Lu W, Luo L, Mandai K, McBain CJ, Nave KA, Prado MAM, Prado VF, Rothstein J, Rubenstein JLR, Saher G, Sakimura K, Sanes JR, Scheiffele P, Takai Y, Umemori H, Verhage M, Yuzaki M, Zoghbi HY, Kawabe H, Craig AM. Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron. 2020 04 08; 106(1):37-65.e5. PMID: 32027825; PMCID: PMC7377387.
    Citations: 36     Fields:    Translation:AnimalsCells
  19. Perez-Cervantes C, Smith LA, Nadadur RD, Hughes AEO, Wang S, Corbo JC, Cepko C, Lonfat N, Moskowitz IP. Enhancer transcription identifies cis-regulatory elements for photoreceptor cell types. Development. 2020 02 05; 147(3). PMID: 31915147; PMCID: PMC7033740.
    Citations: 10     Fields:    Translation:AnimalsCells
  20. Amamoto R, Zuccaro E, Curry NC, Khurana S, Chen HH, Cepko CL, Arlotta P. FIN-Seq: transcriptional profiling of specific cell types from frozen archived tissue of the human central nervous system. Nucleic Acids Res. 2020 01 10; 48(1):e4. PMID: 31728515; PMCID: PMC7145626.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  21. Amamoto R, Garcia MD, West ER, Choi J, Lapan SW, Lane EA, Perrimon N, Cepko CL. Probe-Seq enables transcriptional profiling of specific cell types from heterogeneous tissue by RNA-based isolation. Elife. 2019 12 09; 8. PMID: 31815670; PMCID: PMC6901332.
    Citations: 10     Fields:    Translation:HumansAnimals
  22. Kishi JY, Lapan SW, Beliveau BJ, West ER, Zhu A, Sasaki HM, Saka SK, Wang Y, Cepko CL, Yin P. SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues. Nat Methods. 2019 06; 16(6):533-544. PMID: 31110282.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  23. Wang SK, Xue Y, Rana P, Hong CM, Cepko CL. Soluble CX3CL1 gene therapy improves cone survival and function in mouse models of retinitis pigmentosa. Proc Natl Acad Sci U S A. 2019 05 14; 116(20):10140-10149. PMID: 31036641; PMCID: PMC6525490.
    Citations: 17     Fields:    Translation:AnimalsCells
  24. Xiong W, Wu DM, Xue Y, Wang SK, Chung MJ, Ji X, Rana P, Zhao SR, Mai S, Cepko CL. AAV cis-regulatory sequences are correlated with ocular toxicity. Proc Natl Acad Sci U S A. 2019 03 19; 116(12):5785-5794. PMID: 30833387; PMCID: PMC6431174.
    Citations: 70     Fields:    Translation:AnimalsCells
  25. Guo N, Soden ME, Herber C, Kim MT, Besnard A, Lin P, Ma X, Cepko CL, Zweifel LS, Sahay A. Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization. Nat Med. 2018 05; 24(4):438-449. PMID: 29529016; PMCID: PMC5893385.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  26. Cheong SK, Xiong W, Strazzeri JM, Cepko CL, Williams DR, Merigan WH. In Vivo Functional Imaging of Retinal Neurons Using Red and Green Fluorescent Calcium Indicators. Adv Exp Med Biol. 2018; 1074:135-144. PMID: 29721937.
    Citations: 2     Fields:    Translation:AnimalsCells
  27. da Silva S, Cepko CL. Fgf8 Expression and Degradation of Retinoic Acid Are Required for Patterning a High-Acuity Area in the Retina. Dev Cell. 2017 07 10; 42(1):68-81.e6. PMID: 28648799; PMCID: PMC5798461.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  28. Chinchore Y, Begaj T, Wu D, Drokhlyansky E, Cepko CL. Glycolytic reliance promotes anabolism in photoreceptors. Elife. 2017 06 09; 6. PMID: 28598329.
    Citations: 63     Fields:    Translation:AnimalsCells
  29. Tang JCY, Rudolph S, Cepko CL. Viral Delivery of GFP-Dependent Recombinases to the Mouse Brain. Methods Mol Biol. 2017; 1642:109-126. PMID: 28815497.
    Citations: 4     Fields:    Translation:AnimalsCells
  30. Drokhlyansky E, Göz Aytürk D, Soh TK, Chrenek R, O'Loughlin E, Madore C, Butovsky O, Cepko CL. The brain parenchyma has a type I interferon response that can limit virus spread. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):E95-E104. PMID: 27980033; PMCID: PMC5224383.
    Citations: 27     Fields:    Translation:AnimalsCells
  31. Shekhar K, Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M, Adiconis X, Levin JZ, Nemesh J, Goldman M, McCarroll SA, Cepko CL, Regev A, Sanes JR. Comprehensive Classification of Retinal Bipolar Neurons by Single-Cell Transcriptomics. Cell. 2016 Aug 25; 166(5):1308-1323.e30. PMID: 27565351.
    Citations: 426     Fields:    Translation:AnimalsCells
  32. Tang JC, Drokhlyansky E, Etemad B, Rudolph S, Guo B, Wang S, Ellis EG, Li JZ, Cepko CL. Detection and manipulation of live antigen-expressing cells using conditionally stable nanobodies. Elife. 2016 05 20; 5. PMID: 27205882.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  33. Wang S, Cepko CL. Photoreceptor Fate Determination in the Vertebrate Retina. Invest Ophthalmol Vis Sci. 2016 04 01; 57(5):ORSFe1-6. PMID: 27116662; PMCID: PMC5992959.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  34. Beier KT, Mundell NA, Pan YA, Cepko CL. Anterograde or Retrograde Transsynaptic Circuit Tracing in Vertebrates with Vesicular Stomatitis Virus Vectors. Curr Protoc Neurosci. 2016 Jan 04; 74:1.26.1-1.26.27. PMID: 26729030.
    Citations: 10     Fields:    Translation:AnimalsCells
  35. Xiong W, Cepko C. Distinct Expression Patterns of AAV8 Vectors with Broadly Active Promoters from Subretinal Injections of Neonatal Mouse Eyes at Two Different Ages. Adv Exp Med Biol. 2016; 854:501-7. PMID: 26427452.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  36. Cepko CL. The Determination of Rod and Cone Photoreceptor Fate. Annu Rev Vis Sci. 2015 Nov 24; 1:211-234. PMID: 28532380.
    Citations: 15     Fields:    
  37. Drokhlyansky E, Soh TK, Cepko CL. Preferential Budding of Vesicular Stomatitis Virus from the Basolateral Surface of Polarized Epithelial Cells Is Not Solely Directed by Matrix Protein or Glycoprotein. J Virol. 2015 Nov; 89(22):11718-22. PMID: 26339064; PMCID: PMC4645653.
    Citations: 5     Fields:    Translation:Cells
  38. Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein AR. Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons. Neuron. 2015 Sep 02; 87(5):999-1007. PMID: 26299474.
    Citations: 49     Fields:    Translation:AnimalsCells
  39. Mayer C, Jaglin XH, Cobbs LV, Bandler RC, Streicher C, Cepko CL, Hippenmeyer S, Fishell G. Clonally Related Forebrain Interneurons Disperse Broadly across Both Functional Areas and Structural Boundaries. Neuron. 2015 Sep 02; 87(5):989-98. PMID: 26299473; PMCID: PMC4560602.
    Citations: 55     Fields:    Translation:AnimalsCells
  40. Tang JC, Rudolph S, Dhande OS, Abraira VE, Choi S, Lapan SW, Drew IR, Drokhlyansky E, Huberman AD, Regehr WG, Cepko CL. Cell type-specific manipulation with GFP-dependent Cre recombinase. Nat Neurosci. 2015 Sep; 18(9):1334-41. PMID: 26258682; PMCID: PMC4839275.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  41. Nassi JJ, Cepko CL, Born RT, Beier KT. Neuroanatomy goes viral! Front Neuroanat. 2015; 9:80. PMID: 26190977; PMCID: PMC4486834.
    Citations: 75     
  42. Cepko C, Punzo C. Cell metabolism: Sugar for sight. Nature. 2015 Jun 25; 522(7557):428-9. PMID: 26108850.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  43. Fuentealba LC, Rompani SB, Parraguez JI, Obernier K, Romero R, Cepko CL, Alvarez-Buylla A. Embryonic Origin of Postnatal Neural Stem Cells. Cell. 2015 Jun 18; 161(7):1644-55. PMID: 26091041.
    Citations: 191     Fields:    Translation:AnimalsCells
  44. Fine I, Cepko CL, Landy MS. Vision research special issue: Sight restoration: Prosthetics, optogenetics and gene therapy. Vision Res. 2015 Jun; 111(Pt B):115-23. PMID: 25937376.
    Citations: 9     Fields:    Translation:Humans
  45. Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN. Lassa-vesicular stomatitis chimeric virus safely destroys brain tumors. J Virol. 2015 Jul; 89(13):6711-24. PMID: 25878115; PMCID: PMC4468483.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  46. Mundell NA, Beier KT, Pan YA, Lapan SW, Göz Aytürk D, Berezovskii VK, Wark AR, Drokhlyansky E, Bielecki J, Born RT, Schier AF, Cepko CL. Vesicular stomatitis virus enables gene transfer and transsynaptic tracing in a wide range of organisms. J Comp Neurol. 2015 Aug 01; 523(11):1639-63. PMID: 25688551; PMCID: PMC4458151.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  47. Xiong W, MacColl Garfinkel AE, Li Y, Benowitz LI, Cepko CL. NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. J Clin Invest. 2015 Apr; 125(4):1433-45. PMID: 25798616; PMCID: PMC4396467.
    Citations: 110     Fields:    Translation:AnimalsCells
  48. Wang S, Sengel C, Emerson MM, Cepko CL. A gene regulatory network controls the binary fate decision of rod and bipolar cells in the vertebrate retina. Dev Cell. 2014 Sep 08; 30(5):513-27. PMID: 25155555; PMCID: PMC4304698.
    Citations: 85     Fields:    Translation:AnimalsCells
  49. Cepko C. Intrinsically different retinal progenitor cells produce specific types of progeny. Nat Rev Neurosci. 2014 Sep; 15(9):615-27. PMID: 25096185.
    Citations: 153     Fields:    Translation:AnimalsCells
  50. Sukhdeo K, Koch CE, Miller TE, Zhou H, Rivera M, Yan K, Cepko CL, Lathia JD, Rich JN. The Lgr5 transgene is expressed specifically in glycinergic amacrine cells in the mouse retina. Exp Eye Res. 2014 Feb; 119:106-10. PMID: 24246263.
    Citations: 12     Fields:    Translation:AnimalsCells
  51. Mizeracka K, Trimarchi JM, Stadler MB, Cepko CL. Analysis of gene expression in wild-type and Notch1 mutant retinal cells by single cell profiling. Dev Dyn. 2013 Oct; 242(10):1147-59. PMID: 23813500; PMCID: PMC3882027.
    Citations: 12     Fields:    Translation:AnimalsCells
  52. Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B, Cepko CL. A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell. 2013 Aug 15; 154(4):928-39. PMID: 23953120; PMCID: PMC4096992.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  53. Jiang H, Wang L, Beier KT, Cepko CL, Fekete DM, Brigande JV. Lineage analysis of the late otocyst stage mouse inner ear by transuterine microinjection of a retroviral vector encoding alkaline phosphatase and an oligonucleotide library. PLoS One. 2013; 8(7):e69314. PMID: 23935981.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  54. Emerson MM, Surzenko N, Goetz JJ, Trimarchi J, Cepko CL. Otx2 and Onecut1 promote the fates of cone photoreceptors and horizontal cells and repress rod photoreceptors. Dev Cell. 2013 Jul 15; 26(1):59-72. PMID: 23867227.
    Citations: 53     Fields:    Translation:AnimalsCells
  55. Mizeracka K, DeMaso CR, Cepko CL. Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate. Development. 2013 Aug; 140(15):3188-97. PMID: 23824579.
    Citations: 30     Fields:    Translation:AnimalsCells
  56. Cepko CL, Vandenberghe LH. Retinal gene therapy coming of age. Hum Gene Ther. 2013 Mar; 24(3):242-4. PMID: 23458444.
    Citations: 24     Fields:    
  57. Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo. Front Neural Circuits. 2013; 7:11. PMID: 23403489.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  58. Whited JL, Tsai SL, Beier KT, White JN, Piekarski N, Hanken J, Cepko CL, Tabin CJ. Pseudotyped retroviruses for infecting axolotl in vivo and in vitro. Development. 2013 Mar; 140(5):1137-46. PMID: 23344705.
    Citations: 24     Fields:    Translation:AnimalsCells
  59. Beier KT, Borghuis BG, El-Danaf RN, Huberman AD, Demb JB, Cepko CL. Transsynaptic tracing with vesicular stomatitis virus reveals novel retinal circuitry. J Neurosci. 2013 Jan 02; 33(1):35-51. PMID: 23283320; PMCID: PMC3711516.
    Citations: 34     Fields:    Translation:AnimalsCells
  60. Beier K, Cepko C. Viral tracing of genetically defined neural circuitry. J Vis Exp. 2012 Oct 17; (68). PMID: 23117695.
    Citations: 2     Fields:    Translation:AnimalsCells
  61. Roesch K, Stadler MB, Cepko CL. Gene expression changes within Müller glial cells in retinitis pigmentosa. Mol Vis. 2012; 18:1197-214. PMID: 22665967.
    Citations: 44     Fields:    Translation:AnimalsCells
  62. Cepko CL. Emerging gene therapies for retinal degenerations. J Neurosci. 2012 May 09; 32(19):6415-20. PMID: 22573664; PMCID: PMC3392151.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  63. Hafler BP, Surzenko N, Beier KT, Punzo C, Trimarchi JM, Kong JH, Cepko CL. Transcription factor Olig2 defines subpopulations of retinal progenitor cells biased toward specific cell fates. Proc Natl Acad Sci U S A. 2012 May 15; 109(20):7882-7. PMID: 22543161.
    Citations: 65     Fields:    Translation:AnimalsCells
  64. Punzo C, Xiong W, Cepko CL. Loss of daylight vision in retinal degeneration: are oxidative stress and metabolic dysregulation to blame? J Biol Chem. 2012 Jan 13; 287(3):1642-8. PMID: 22074929.
    Citations: 87     Fields:    Translation:HumansAnimals
  65. Emerson MM, Cepko CL. Identification of a retina-specific Otx2 enhancer element active in immature developing photoreceptors. Dev Biol. 2011 Dec 01; 360(1):241-55. PMID: 21963459.
    Citations: 32     Fields:    Translation:AnimalsCells
  66. Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith LE, Siemann DW, Kladde MP, Cepko CL, Lu J. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6. PMID: 21896759.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  67. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15414-9. PMID: 21825165.
    Citations: 86     Fields:    Translation:AnimalsCells
  68. Cronican JJ, Beier KT, Davis TN, Tseng JC, Li W, Thompson DB, Shih AF, May EM, Cepko CL, Kung AL, Zhou Q, Liu DR. A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo. Chem Biol. 2011 Jul 29; 18(7):833-8. PMID: 21802004; PMCID: PMC3154086.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  69. Cherry TJ, Wang S, Bormuth I, Schwab M, Olson J, Cepko CL. NeuroD factors regulate cell fate and neurite stratification in the developing retina. J Neurosci. 2011 May 18; 31(20):7365-79. PMID: 21593321.
    Citations: 45     Fields:    Translation:AnimalsCells
  70. Beier KT, Samson ME, Matsuda T, Cepko CL. Conditional expression of the TVA receptor allows clonal analysis of descendents from Cre-expressing progenitor cells. Dev Biol. 2011 May 15; 353(2):309-20. PMID: 21397594.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  71. Huynh MA, Ikeuchi Y, Netherton S, de la Torre-Ubieta L, Kanadia R, Stegmüller J, Cepko C, Bonni S, Bonni A. An isoform-specific SnoN1-FOXO1 repressor complex controls neuronal morphogenesis and positioning in the mammalian brain. Neuron. 2011 Mar 10; 69(5):930-44. PMID: 21382553; PMCID: PMC3073069.
    Citations: 22     Fields:    Translation:AnimalsCells
  72. Billings NA, Emerson MM, Cepko CL. Analysis of thyroid response element activity during retinal development. PLoS One. 2010 Oct 29; 5(10):e13739. PMID: 21060789.
    Citations: 17     Fields:    Translation:HumansCells
  73. Cronican JJ, Thompson DB, Beier KT, McNaughton BR, Cepko CL, Liu DR. Potent delivery of functional proteins into Mammalian cells in vitro and in vivo using a supercharged protein. ACS Chem Biol. 2010 Aug 20; 5(8):747-52. PMID: 20545362.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  74. Cepko C. Neuroscience. Seeing the light of day. Science. 2010 Jul 23; 329(5990):403-4. PMID: 20651144.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  75. Rompani SB, Cepko CL. A common progenitor for retinal astrocytes and oligodendrocytes. J Neurosci. 2010 Apr 07; 30(14):4970-80. PMID: 20371817; PMCID: PMC3536471.
    Citations: 23     Fields:    Translation:AnimalsCells
  76. Bienvenu F, Jirawatnotai S, Elias JE, Meyer CA, Mizeracka K, Marson A, Frampton GM, Cole MF, Odom DT, Odajima J, Geng Y, Zagozdzon A, Jecrois M, Young RA, Liu XS, Cepko CL, Gygi SP, Sicinski P. Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen. Nature. 2010 Jan 21; 463(7279):374-8. PMID: 20090754.
    Citations: 136     Fields:    Translation:AnimalsCells
  77. Kanadia RN, Cepko CL. Alternative splicing produces high levels of noncoding isoforms of bHLH transcription factors during development. Genes Dev. 2010 Feb 01; 24(3):229-34. PMID: 20080942.
    Citations: 5     Fields:    Translation:AnimalsCells
  78. Samson M, Emerson MM, Cepko CL. Robust marking of photoreceptor cells and pinealocytes with several reporters under control of the Crx gene. Dev Dyn. 2009 Dec; 238(12):3218-25. PMID: 19882727.
    Citations: 13     Fields:    Translation:AnimalsCells
  79. Trimarchi JM, Cho SH, Cepko CL. Identification of genes expressed preferentially in the developing peripheral margin of the optic cup. Dev Dyn. 2009 Sep; 238(9):2327-9. PMID: 19449303; PMCID: PMC2916742.
    Citations: 27     Fields:    Translation:Animals
  80. Cherry TJ, Trimarchi JM, Stadler MB, Cepko CL. Development and diversification of retinal amacrine interneurons at single cell resolution. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9495-500. PMID: 19470466.
    Citations: 58     Fields:    Translation:AnimalsCells
  81. Jadhav AP, Roesch K, Cepko CL. Development and neurogenic potential of Müller glial cells in the vertebrate retina. Prog Retin Eye Res. 2009 Jul; 28(4):249-62. PMID: 19465144.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  82. Dyer MA, Martins R, da Silva Filho M, Muniz JA, Silveira LC, Cepko CL, Finlay BL. Developmental sources of conservation and variation in the evolution of the primate eye. Proc Natl Acad Sci U S A. 2009 Jun 02; 106(22):8963-8. PMID: 19451636.
    Citations: 37     Fields:    Translation:AnimalsCells
  83. Chen B, Cepko CL. HDAC4 regulates neuronal survival in normal and diseased retinas. Science. 2009 Jan 09; 323(5911):256-9. PMID: 19131628.
    Citations: 100     Fields:    Translation:AnimalsCells
  84. Punzo C, Kornacker K, Cepko CL. Stimulation of the insulin/mTOR pathway delays cone death in a mouse model of retinitis pigmentosa. Nat Neurosci. 2009 Jan; 12(1):44-52. PMID: 19060896; PMCID: PMC3339764.
    Citations: 252     Fields:    Translation:AnimalsCells
  85. Kanadia RN, Clark VE, Punzo C, Trimarchi JM, Cepko CL. Temporal requirement of the alternative-splicing factor Sfrs1 for the survival of retinal neurons. Development. 2008 Dec; 135(23):3923-33. PMID: 18987029; PMCID: PMC3593640.
    Citations: 11     Fields:    Translation:AnimalsCells
  86. Trimarchi JM, Harpavat S, Billings NA, Cepko CL. Thyroid hormone components are expressed in three sequential waves during development of the chick retina. BMC Dev Biol. 2008 Oct 14; 8:101. PMID: 18854032; PMCID: PMC2579430.
    Citations: 35     Fields:    Translation:AnimalsCells
  87. Kim DS, Matsuda T, Cepko CL. A core paired-type and POU homeodomain-containing transcription factor program drives retinal bipolar cell gene expression. J Neurosci. 2008 Jul 30; 28(31):7748-64. PMID: 18667607; PMCID: PMC2714707.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  88. Roesch K, Jadhav AP, Trimarchi JM, Stadler MB, Roska B, Sun BB, Cepko CL. The transcriptome of retinal Müller glial cells. J Comp Neurol. 2008 Jul 10; 509(2):225-38. PMID: 18465787.
    Citations: 181     Fields:    Translation:AnimalsCells
  89. Nygaard V, Liu F, Holden M, Kuo WP, Trimarchi J, Ohno-Machado L, Cepko CL, Frigessi A, Glad IK, Wiel MA, Hovig E, Lyng H. Validation of oligoarrays for quantitative exploration of the transcriptome. BMC Genomics. 2008 May 30; 9:258. PMID: 18513391.
    Citations: 2     Fields:    Translation:Animals
  90. Damiani D, Alexander JJ, O'Rourke JR, McManus M, Jadhav AP, Cepko CL, Hauswirth WW, Harfe BD, Strettoi E. Dicer inactivation leads to progressive functional and structural degeneration of the mouse retina. J Neurosci. 2008 May 07; 28(19):4878-87. PMID: 18463241.
    Citations: 127     Fields:    Translation:Animals
  91. Lagali PS, Balya D, Awatramani GB, Münch TA, Kim DS, Busskamp V, Cepko CL, Roska B. Light-activated channels targeted to ON bipolar cells restore visual function in retinal degeneration. Nat Neurosci. 2008 Jun; 11(6):667-75. PMID: 18432197.
    Citations: 237     Fields:    Translation:AnimalsCells
  92. Kim DS, Ross SE, Trimarchi JM, Aach J, Greenberg ME, Cepko CL. Identification of molecular markers of bipolar cells in the murine retina. J Comp Neurol. 2008 Apr 10; 507(5):1795-810. PMID: 18260140.
    Citations: 71     Fields:    Translation:AnimalsCells
  93. Punzo C, Cepko CL. Ultrasound-guided in utero injections allow studies of the development and function of the eye. Dev Dyn. 2008 Apr; 237(4):1034-42. PMID: 18351670.
    Citations: 17     Fields:    Translation:Animals
  94. Trimarchi JM, Stadler MB, Cepko CL. Individual retinal progenitor cells display extensive heterogeneity of gene expression. PLoS One. 2008 Feb 13; 3(2):e1588. PMID: 18270576.
    Citations: 92     Fields:    Translation:AnimalsCells
  95. Morrow EM, Chen CM, Cepko CL. Temporal order of bipolar cell genesis in the neural retina. Neural Dev. 2008 Jan 23; 3:2. PMID: 18215319.
    Citations: 36     Fields:    Translation:AnimalsCells
  96. Matsuda T, Cepko CL. Analysis of gene function in the retina. Methods Mol Biol. 2008; 423:259-78. PMID: 18370205.
    Citations: 19     Fields:    Translation:Animals
  97. Rompani SB, Cepko CL. Retinal progenitor cells can produce restricted subsets of horizontal cells. Proc Natl Acad Sci U S A. 2008 Jan 08; 105(1):192-7. PMID: 18162542; PMCID: PMC2224184.
    Citations: 37     Fields:    Translation:AnimalsCells
  98. Hsiau TH, Diaconu C, Myers CA, Lee J, Cepko CL, Corbo JC. The cis-regulatory logic of the mammalian photoreceptor transcriptional network. PLoS One. 2007 Jul 25; 2(7):e643. PMID: 17653270.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  99. Corbo JC, Myers CA, Lawrence KA, Jadhav AP, Cepko CL. A typology of photoreceptor gene expression patterns in the mouse. Proc Natl Acad Sci U S A. 2007 Jul 17; 104(29):12069-74. PMID: 17620597; PMCID: PMC1913549.
    Citations: 54     Fields: