Harvard Catalyst Profiles

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Paula Ivonne Watnick, M.D., Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI158247 (WATNICK, PAULA I) Sep 24, 2021 - Aug 31, 2026
    Control of intestinal innate immunity by the commensal microbiota in a model host
    Role: Principal Investigator
  2. R01AI162701 (WATNICK, PAULA I) Jun 1, 2021 - May 31, 2026
    Vibrio cholerae quorum sensing as an intestinal symbiosis factor in a model arthropod host
    Role: Principal Investigator
  3. R56AI145887 (WATNICK, PAULA I) Sep 3, 2020 - Aug 31, 2021
    Development of a live-attenuated, sublingual vaccine against diarrheal disease
    Role: Principal Investigator
  4. R21AI115023 (WATNICK, PAULA I) Jun 15, 2015 - Nov 30, 2018
    The role of proteolysis in bacterial biofilm formation
    Role: Principal Investigator
  5. R21AI115303 (WATNICK, PAULA I) May 4, 2015 - Apr 30, 2018
    Biofilm matrix-based vaccines
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gibson JA, Gebhardt MJ, Santos RERS, Dove SL, Watnick PI. Sequestration of a dual function DNA-binding protein by Vibrio cholerae CRP. Proc Natl Acad Sci U S A. 2022 Nov 16; 119(46):e2210115119. PMID: 36343262; PMCID: PMC9674212.
    Citations:    Fields:    Translation:Cells
  2. Jugder BE, Batista JH, Gibson JA, Cunningham PM, Asara JM, Watnick PI. Vibrio cholerae high cell density quorum sensing activates the host intestinal innate immune response. Cell Rep. 2022 09 20; 40(12):111368. PMID: 36130487; PMCID: PMC9534793.
    Citations:    Fields:    Translation:HumansCells
  3. Chen Y, Rudolph SE, Longo BN, Pace F, Roh TT, Condruti R, Gee M, Watnick PI, Kaplan DL. Bioengineered 3D Tissue Model of Intestine Epithelium with Oxygen Gradients to Sustain Human Gut Microbiome. Adv Healthc Mater. 2022 08; 11(16):e2200447. PMID: 35686484; PMCID: PMC9388577.
    Citations:    Fields:    
  4. Pace F, Rudolph SE, Chen Y, Bao B, Kaplan DL, Watnick PI. The Short-Chain Fatty Acids Propionate and Butyrate Augment Adherent-Invasive Escherichia coli Virulence but Repress Inflammation in a Human Intestinal Enteroid Model of Infection. Microbiol Spectr. 2021 10 31; 9(2):e0136921. PMID: 34612688; PMCID: PMC8510176.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Jugder BE, Kamareddine L, Watnick PI. Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex. Immunity. 2021 08 10; 54(8):1683-1697.e3. PMID: 34107298; PMCID: PMC8363570.
    Citations: 8     Fields:    Translation:AnimalsCells
  6. Pace F, Watnick PI. The Interplay of Sex Steroids, the Immune Response, and the Intestinal Microbiota. Trends Microbiol. 2021 09; 29(9):849-859. PMID: 33257138.
    Citations: 4     Fields:    Translation:HumansAnimals
  7. Vanhove AS, Jugder BE, Barraza D, Watnick PI. Methionine Availability in the Arthropod Intestine Is Elucidated through Identification of Vibrio cholerae Methionine Acquisition Systems. Appl Environ Microbiol. 2020 05 19; 86(11). PMID: 32220836.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Jugder BE, Watnick PI. Vibrio cholerae Sheds Its Coat to Make Itself Comfortable in the Gut. Cell Host Microbe. 2020 02 12; 27(2):161-163. PMID: 32053783.
    Citations:    Fields:    Translation:HumansAnimalsCells
  9. Watnick PI, Jugder BE. Microbial Control of Intestinal Homeostasis via Enteroendocrine Cell Innate Immune Signaling. Trends Microbiol. 2020 02; 28(2):141-149. PMID: 31699645.
    Citations: 4     Fields:    Translation:AnimalsCells
  10. Liao J, Xu G, Mevers EE, Clardy J, Watnick PI. A high-throughput, whole cell assay to identify compounds active against carbapenem-resistant Klebsiella pneumoniae. PLoS One. 2018; 13(12):e0209389. PMID: 30576339; PMCID: PMC6303040.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. Vijayakumar V, Vanhove AS, Pickering BS, Liao J, Tierney BT, Asara JM, Bronson R, Watnick PI. Removal of a Membrane Anchor Reveals the Opposing Regulatory Functions of Vibrio cholerae Glucose-Specific Enzyme IIA in Biofilms and the Mammalian Intestine. mBio. 2018 09 04; 9(5). PMID: 30181246.
    Citations: 3     Fields:    Translation:Cells
  12. Liao J, Smith DR, Brynjarsdóttir J, Watnick PI. A Self-Assembling Whole-Cell Vaccine Antigen Presentation Platform. J Bacteriol. 2018 08 01; 200(15). PMID: 29483163; PMCID: PMC6040178.
    Citations: 1     Fields:    Translation:AnimalsCells
  13. Kamareddine L, Robins WP, Berkey CD, Mekalanos JJ, Watnick PI. The Drosophila Immune Deficiency Pathway Modulates Enteroendocrine Function and Host Metabolism. Cell Metab. 2018 09 04; 28(3):449-462.e5. PMID: 29937377; PMCID: PMC6125180.
    Citations: 49     Fields:    Translation:AnimalsCells
  14. Liao J, Gibson JA, Pickering BS, Watnick PI. Sublingual Adjuvant Delivery by a Live Attenuated Vibrio cholerae-Based Antigen Presentation Platform. mSphere. 2018 06 27; 3(3). PMID: 29875145.
    Citations:    Fields:    Translation:AnimalsCells
  15. Kamareddine L, Wong ACN, Vanhove AS, Hang S, Purdy AE, Kierek-Pearson K, Asara JM, Ali A, Morris JG, Watnick PI. Activation of Vibrio cholerae quorum sensing promotes survival of an arthropod host. Nat Microbiol. 2018 02; 3(2):243-252. PMID: 29180725.
    Citations: 15     Fields:    Translation:AnimalsCells
  16. Vanhove AS, Hang S, Vijayakumar V, Wong AC, Asara JM, Watnick PI. Vibrio cholerae ensures function of host proteins required for virulence through consumption of luminal methionine sulfoxide. PLoS Pathog. 2017 Jun; 13(6):e1006428. PMID: 28586382; PMCID: PMC5473594.
    Citations: 12     Fields:    Translation:AnimalsCells
  17. Alawdah LS, Campbell JN, Pollock N, Watnick PI. Erysipelothrix rhusiopathiae Suppurative Arthritis in a 12-year-old Boy After an Unusual Fresh Water Exposure. Pediatr Infect Dis J. 2017 04; 36(4):431-433. PMID: 27977547.
    Citations: 2     Fields:    Translation:HumansAnimals
  18. Wong AC, Vanhove AS, Watnick PI. The interplay between intestinal bacteria and host metabolism in health and disease: lessons from Drosophila melanogaster. Dis Model Mech. 2016 Mar; 9(3):271-81. PMID: 26935105.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  19. Leng Y, Vakulskas CA, Zere TR, Pickering BS, Watnick PI, Babitzke P, Romeo T. Regulation of CsrB/C sRNA decay by EIIA(Glc) of the phosphoenolpyruvate: carbohydrate phosphotransferase system. Mol Microbiol. 2016 Feb; 99(4):627-39. PMID: 26507976; PMCID: PMC4888959.
    Citations: 27     Fields:    Translation:Cells
  20. Smith DR, Maestre-Reyna M, Lee G, Gerard H, Wang AH, Watnick PI. In situ proteolysis of the Vibrio cholerae matrix protein RbmA promotes biofilm recruitment. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10491-6. PMID: 26240338; PMCID: PMC4547210.
    Citations: 26     Fields:    Translation:Cells
  21. Hang S, Purdy AE, Robins WP, Wang Z, Mandal M, Chang S, Mekalanos JJ, Watnick PI. The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Cell Host Microbe. 2014 Nov 12; 16(5):592-604. PMID: 25525791; PMCID: PMC4272434.
    Citations: 50     Fields:    Translation:AnimalsCells
  22. Pickering BS, Lopilato JE, Smith DR, Watnick PI. The transcription factor Mlc promotes Vibrio cholerae biofilm formation through repression of phosphotransferase system components. J Bacteriol. 2014 Jul; 196(13):2423-30. PMID: 24769694.
    Citations: 6     Fields:    Translation:Cells
  23. Guichard A, Cruz-Moreno B, Cruz-Moreno BC, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Cell Host Microbe. 2013 Sep 11; 14(3):294-305. PMID: 24034615.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  24. Wang Z, Hang S, Purdy AE, Watnick PI. Mutations in the IMD pathway and mustard counter Vibrio cholerae suppression of intestinal stem cell division in Drosophila. mBio. 2013 Jun 18; 4(3):e00337-13. PMID: 23781070.
    Citations: 19     Fields:    Translation:AnimalsCells
  25. Ymele-Leki P, Houot L, Watnick PI. Mannitol and the mannitol-specific enzyme IIB subunit activate Vibrio cholerae biofilm formation. Appl Environ Microbiol. 2013 Aug; 79(15):4675-83. PMID: 23728818.
    Citations: 16     Fields:    Translation:Cells
  26. Pickering BS, Smith DR, Watnick PI. Glucose-specific enzyme IIA has unique binding partners in the vibrio cholerae biofilm. mBio. 2012 Nov 06; 3(6):e00228-12. PMID: 23131828.
    Citations: 20     Fields:    Translation:Cells
  27. Absalon C, Ymele-Leki P, Watnick PI. The bacterial biofilm matrix as a platform for protein delivery. mBio. 2012; 3(4):e00127-12. PMID: 22807566.
    Citations: 9     Fields:    Translation:Cells
  28. Wang Z, Berkey CD, Watnick PI. The Drosophila protein mustard tailors the innate immune response activated by the immune deficiency pathway. J Immunol. 2012 Apr 15; 188(8):3993-4000. PMID: 22427641; PMCID: PMC3324637.
    Citations: 22     Fields:    Translation:AnimalsCells
  29. Ymele-Leki P, Cao S, Sharp J, Lambert KG, McAdam AJ, Husson RN, Tamayo G, Clardy J, Watnick PI. A high-throughput screen identifies a new natural product with broad-spectrum antibacterial activity. PLoS One. 2012; 7(2):e31307. PMID: 22359585.
    Citations: 18     Fields:    Translation:AnimalsCells
  30. Purdy AE, Watnick PI. Spatially selective colonization of the arthropod intestine through activation of Vibrio cholerae biofilm formation. Proc Natl Acad Sci U S A. 2011 Dec 06; 108(49):19737-42. PMID: 22106284.
    Citations: 40     Fields:    Translation:AnimalsCells
  31. Absalon C, Van Dellen K, Watnick PI. A communal bacterial adhesin anchors biofilm and bystander cells to surfaces. PLoS Pathog. 2011 Aug; 7(8):e1002210. PMID: 21901100.
    Citations: 66     Fields:    Translation:Cells
  32. Houot L, Chang S, Pickering BS, Absalon C, Watnick PI. The phosphoenolpyruvate phosphotransferase system regulates Vibrio cholerae biofilm formation through multiple independent pathways. J Bacteriol. 2010 Jun; 192(12):3055-67. PMID: 20400550.
    Citations: 48     Fields:    Translation:Cells
  33. Houot L, Chang S, Absalon C, Watnick PI. Vibrio cholerae phosphoenolpyruvate phosphotransferase system control of carbohydrate transport, biofilm formation, and colonization of the germfree mouse intestine. Infect Immun. 2010 Apr; 78(4):1482-94. PMID: 20123708.
    Citations: 42     Fields:    Translation:AnimalsCells
  34. Karatan E, Watnick P. Signals, regulatory networks, and materials that build and break bacterial biofilms. Microbiol Mol Biol Rev. 2009 Jun; 73(2):310-47. PMID: 19487730.
    Citations: 298     Fields:    Translation:HumansAnimalsCells
  35. Berkey CD, Blow N, Watnick PI. Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection. Cell Microbiol. 2009 Mar; 11(3):461-74. PMID: 19046341.
    Citations: 22     Fields:    Translation:AnimalsCells
  36. Van Dellen KL, Houot L, Watnick PI. Genetic analysis of Vibrio cholerae monolayer formation reveals a key role for DeltaPsi in the transition to permanent attachment. J Bacteriol. 2008 Dec; 190(24):8185-96. PMID: 18849423; PMCID: PMC2593239.
    Citations: 24     Fields:    Translation:Cells
  37. Houot L, Watnick PI. A novel role for enzyme I of the Vibrio cholerae phosphoenolpyruvate phosphotransferase system in regulation of growth in a biofilm. J Bacteriol. 2008 Jan; 190(1):311-20. PMID: 17981973.
    Citations: 47     Fields:    Translation:Cells
  38. Karatan E, Duncan TR, Watnick PI. NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine. J Bacteriol. 2005 Nov; 187(21):7434-43. PMID: 16237027; PMCID: PMC1273002.
    Citations: 93     Fields:    Translation:Cells
  39. Blow NS, Salomon RN, Garrity K, Reveillaud I, Kopin A, Jackson FR, Watnick PI. Vibrio cholerae infection of Drosophila melanogaster mimics the human disease cholera. PLoS Pathog. 2005 Sep; 1(1):e8. PMID: 16201020; PMCID: PMC1238743.
    Citations: 50     Fields:    
  40. Moorthy S, Watnick PI. Identification of novel stage-specific genetic requirements through whole genome transcription profiling of Vibrio cholerae biofilm development. Mol Microbiol. 2005 Sep; 57(6):1623-35. PMID: 16135229; PMCID: PMC2600799.
    Citations: 71     Fields:    Translation:Cells
  41. Kapfhammer D, Karatan E, Pflughoeft KJ, Watnick PI. Role for glycine betaine transport in Vibrio cholerae osmoadaptation and biofilm formation within microbial communities. Appl Environ Microbiol. 2005 Jul; 71(7):3840-7. PMID: 16000796; PMCID: PMC1169069.
    Citations: 32     Fields:    Translation:HumansCells
  42. Moorthy S, Watnick PI. Genetic evidence that the Vibrio cholerae monolayer is a distinct stage in biofilm development. Mol Microbiol. 2004 Apr; 52(2):573-87. PMID: 15066042; PMCID: PMC2501105.
    Citations: 56     Fields:    Translation:Cells
  43. Kierek K, Watnick PI. The Vibrio cholerae O139 O-antigen polysaccharide is essential for Ca2+-dependent biofilm development in sea water. Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24):14357-62. PMID: 14614140; PMCID: PMC283596.
    Citations: 56     Fields:    Translation:Cells
  44. Pflughoeft KJ, Kierek K, Watnick PI. Role of ectoine in Vibrio cholerae osmoadaptation. Appl Environ Microbiol. 2003 Oct; 69(10):5919-27. PMID: 14532045.
    Citations: 25     Fields:    Translation:HumansCells
  45. Kierek K, Watnick PI. Environmental determinants of Vibrio cholerae biofilm development. Appl Environ Microbiol. 2003 Sep; 69(9):5079-88. PMID: 12957889.
    Citations: 59     Fields:    Translation:HumansCellsPHPublic Health
  46. Bomchil N, Watnick P, Kolter R. Identification and characterization of a Vibrio cholerae gene, mbaA, involved in maintenance of biofilm architecture. J Bacteriol. 2003 Feb; 185(4):1384-90. PMID: 12562809.
    Citations: 60     Fields:    Translation:Cells
  47. Haugo AJ, Watnick PI. Vibrio cholerae CytR is a repressor of biofilm development. Mol Microbiol. 2002 Jul; 45(2):471-83. PMID: 12123457; PMCID: PMC2515492.
    Citations: 67     Fields:    Translation:Cells
  48. Watnick PI. Paula I Watnick--elucidating the role of biofilms. Interview by Pam Das. Lancet Infect Dis. 2002 Mar; 2(3):190-2. PMID: 11944189.
    Citations:    Fields:    Translation:Cells
  49. Watnick PI, Lauriano CM, Klose KE, Croal L, Kolter R. The absence of a flagellum leads to altered colony morphology, biofilm development and virulence in Vibrio cholerae O139. Mol Microbiol. 2001 Jan; 39(2):223-35. PMID: 11136445; PMCID: PMC2860545.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  50. Watnick P, Kolter R. Biofilm, city of microbes. J Bacteriol. 2000 May; 182(10):2675-9. PMID: 10781532; PMCID: PMC101960.
    Citations: 327     Fields:    
  51. Butterton JR, Choi MH, Watnick PI, Carroll PA, Calderwood SB. Vibrio cholerae VibF is required for vibriobactin synthesis and is a member of the family of nonribosomal peptide synthetases. J Bacteriol. 2000 Mar; 182(6):1731-8. PMID: 10692380.
    Citations: 23     Fields:    Translation:Cells
  52. Watnick PI, Kolter R. Steps in the development of a Vibrio cholerae El Tor biofilm. Mol Microbiol. 1999 Nov; 34(3):586-95. PMID: 10564499; PMCID: PMC2860543.
    Citations: 247     Fields:    Translation:HumansCells
  53. Watnick PI, Fullner KJ, Kolter R. A role for the mannose-sensitive hemagglutinin in biofilm formation by Vibrio cholerae El Tor. J Bacteriol. 1999 Jun; 181(11):3606-9. PMID: 10348878; PMCID: PMC93833.
    Citations: 116     Fields:    Translation:Cells
  54. O'Toole GA, Pratt LA, Watnick PI, Newman DK, Weaver VB, Kolter R. Genetic approaches to study of biofilms. Methods Enzymol. 1999; 310:91-109. PMID: 10547784.
    Citations: 319     Fields:    Translation:Cells
  55. Watnick PI, Butterton JR, Calderwood SB. The interaction of the Vibrio cholerae transcription factors, Fur and IrgB, with the overlapping promoters of two virulence genes, irgA and irgB. Gene. 1998 Mar 16; 209(1-2):65-70. PMID: 9524224.
    Citations: 15     Fields:    Translation:Cells
  56. Watnick PI, Eto T, Takahashi H, Calderwood SB. Purification of Vibrio cholerae fur and estimation of its intracellular abundance by antibody sandwich enzyme-linked immunosorbent assay. J Bacteriol. 1997 Jan; 179(1):243-7. PMID: 8982004; PMCID: PMC178685.
    Citations: 17     Fields:    Translation:Cells
  57. Watnick PI, Chan SI, Dea P. Hydrophobic mismatch in gramicidin A'/lecithin systems. Biochemistry. 1990 Jul 03; 29(26):6215-21. PMID: 1698451.
    Citations: 4     Fields:    Translation:Cells
  58. Watnick PI, Dea P, Chan SI. Characterization of the transverse relaxation rates in lipid bilayers. Proc Natl Acad Sci U S A. 1990 Mar; 87(6):2082-6. PMID: 2315304; PMCID: PMC53630.
    Citations: 7     Fields:    Translation:Cells
  59. Gierasch LM, Lacy JE, Thompson KF, Rockwell AL, Watnick PI. Conformations of model peptides in membrane-mimetic environments. Biophys J. 1982 Jan; 37(1):275-84. PMID: 7055624; PMCID: PMC1329137.
    Citations: 6     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.