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David Mischoulon, PH.D., M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01MH074085 (MISCHOULON, DAVID) Mar 9, 2006 - Feb 28, 2012
    NIH/NIMH
    Omega-3 Fatty Acids for Treatment of Major Depression
    Role: Principal Investigator
  2. K23AT001129 (MISCHOULON, DAVID) Sep 27, 2001 - Aug 31, 2007
    NIH/NCCIH
    Omega-3 Fatty Acids in the Treatment of Depression
    Role: Principal Investigator
  3. M01RR001066 (SLAVIN, PETER L) Feb 1, 1978 - May 31, 2008
    NIH/NCRR
    General Clinical Research Center
    Role: Co-Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kinrys G, Gold AK, Pisano VD, Freeman MP, Papakostas GI, Mischoulon D, Nierenberg AA, Fava M. Tachyphylaxis in major depressive disorder: A review of the current state of research. J Affect Disord. 2018 Oct 28; 245:488-497. PMID: 30439676.
    View in: PubMed
  2. Cassano P, Petrie SR, Mischoulon D, Cusin C, Katnani H, Yeung A, De Taboada L, Archibald A, Bui E, Baer L, Chang T, Chen J, Pedrelli P, Fisher L, Farabaugh A, Hamblin MR, Alpert JE, Fava M, Iosifescu DV. Transcranial Photobiomodulation for the Treatment of Major Depressive Disorder. The ELATED-2 Pilot Trial. Photomed Laser Surg. 2018 Oct 20. PMID: 30346890.
    View in: PubMed
  3. Kim H, Choi KW, Na EJ, Hong JP, Fava M, Mischoulon D, Cho H, Jeon HJ. Anxiety attacks with or without life-threatening situations, major depressive disorder, and suicide attempt: a nationwide community sample of Korean adults. Psychiatry Res. 2018 Sep 21; 270:257-263. PMID: 30273856.
    View in: PubMed
  4. Choi KW, Na EJ, Fava M, Mischoulon D, Cho H, Jeon HJ. Increased adrenocorticotropic hormone (ACTH) levels predict severity of depression after six months of follow-up in outpatients with major depressive disorder. Psychiatry Res. 2018 Sep 21; 270:246-252. PMID: 30269042.
    View in: PubMed
  5. Cassano P, Dording C, Thomas G, Foster S, Yeung A, Uchida M, Hamblin MR, Bui E, Fava M, Mischoulon D, Iosifescu DV. Effects of transcranial photobiomodulation with near-infrared light on sexual dysfunction. Lasers Surg Med. 2018 Sep 17. PMID: 30221776.
    View in: PubMed
  6. Ionescu DF, Bentley KH, Eikermann M, Taylor N, Akeju O, Swee MB, Pavone KJ, Petrie SR, Dording C, Mischoulon D, Alpert JE, Brown EN, Baer L, Nock MK, Fava M, Cusin C. Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial. J Affect Disord. 2019 Jan 15; 243:516-524. PMID: 30286416.
    View in: PubMed
  7. Laferton JAC, Vijapura S, Baer L, Clain AJ, Cooper A, Papakostas G, Price LH, Carpenter LL, Tyrka AR, Fava M, Mischoulon D. Mechanisms of Perceived Treatment Assignment and Subsequent Expectancy Effects in a Double Blind Placebo Controlled RCT of Major Depression. Front Psychiatry. 2018; 9:424. PMID: 30245644.
    View in: PubMed
  8. Mischoulon D, Rapaport MH. Current Role of Herbal and Natural Preparations. Handb Exp Pharmacol. 2018 Aug 24. PMID: 30141099.
    View in: PubMed
  9. Sarris J, Byrne GJ, Bousman C, Stough C, Murphy J, MacDonald P, Adams L, Nazareth S, Oliver G, Cribb L, Savage K, Menon R, Chamoli S, Berk M, Ng C, Mischoulon D. Adjunctive S-adenosylmethionine (SAMe) in treating non-remittent major depressive disorder: An 8-week double-blind, randomized, controlled trial. Eur Neuropsychopharmacol. 2018 Oct; 28(10):1126-1136. PMID: 30115553.
    View in: PubMed
  10. Schuster RM, Pachas GN, Stoeckel L, Cather C, Nadal M, Mischoulon D, Schoenfeld DA, Zhang H, Ulysse C, Dodds EB, Sobolewski S, Hudziak V, Hanly A, Fava M, Evins AE. Phase IIb Trial of an a7 Nicotinic Receptor Partial Agonist With and Without Nicotine Patch for Withdrawal-Associated Cognitive Deficits and Tobacco Abstinence. J Clin Psychopharmacol. 2018 Aug; 38(4):307-316. PMID: 29912798.
    View in: PubMed
  11. Baek JH, Kim K, Hong JP, Cho MJ, Fava M, Mischoulon D, Chang SM, Kim JY, Cho H, Jeon HJ. Binge eating, trauma, and suicide attempt in community adults with major depressive disorder. PLoS One. 2018; 13(6):e0198192. PMID: 29927937.
    View in: PubMed
  12. Okereke OI, Reynolds CF, Mischoulon D, Chang G, Cook NR, Copeland T, Friedenberg G, Buring JE, Manson JE. The VITamin D and OmegA-3 TriaL-Depression Endpoint Prevention (VITAL-DEP): Rationale and design of a large-scale ancillary study evaluating vitamin D and marine omega-3 fatty acid supplements for prevention of late-life depression. Contemp Clin Trials. 2018 May; 68:133-145. PMID: 29526608.
    View in: PubMed
  13. Nyer M, Gerbarg PL, Silveri MM, Johnston J, Scott TM, Nauphal M, Owen L, Nielsen GH, Mischoulon D, Brown RP, Fava M, Streeter CC. A randomized controlled dosing study of Iyengar yoga and coherent breathing for the treatment of major depressive disorder: Impact on suicidal ideation and safety findings. Complement Ther Med. 2018 Apr; 37:136-142. PMID: 29609926.
    View in: PubMed
  14. Vance MC, Bui E, Hoeppner SS, Kovachy B, Prescott J, Mischoulon D, Walton ZE, Dong M, Nadal MF, Worthington JJ, Hoge EA, Cassano P, Orr EH, Fava M, de Vivo I, Wong KK, Simon NM. Prospective association between major depressive disorder and leukocyte telomere length over two years. Psychoneuroendocrinology. 2018 Apr; 90:157-164. PMID: 29499556.
    View in: PubMed
  15. Gao J, Cahill CM, Huang X, Roffman JL, Lamon-Fava S, Fava M, Mischoulon D, Rogers JT. S-Adenosyl Methionine and Transmethylation Pathways in Neuropsychiatric Diseases Throughout Life. Neurotherapeutics. 2018 Jan; 15(1):156-175. PMID: 29340929.
    View in: PubMed
  16. de Jong M, Peeters F, Gard T, Ashih H, Doorley J, Walker R, Rhoades L, Kulich RJ, Kueppenbender KD, Alpert JE, Hoge EA, Britton WB, Lazar SW, Fava M, Mischoulon D. A Randomized Controlled Pilot Study on Mindfulness-Based Cognitive Therapy for Unipolar Depression in Patients With Chronic Pain. J Clin Psychiatry. 2018 Jan/Feb; 79(1). PMID: 28252881.
    View in: PubMed
  17. Moonga SS, Mischoulon D, Winkelman JW, Stern TA. Obstructive Sleep Apnea as a Complication of Bipolar Disorder and Its Treatment: A Review and Approach to Management. Prim Care Companion CNS Disord. 2017 Nov 30; 19(6). PMID: 29195035.
    View in: PubMed
  18. Kim K, Kim SW, Myung W, Han CE, Fava M, Mischoulon D, Papakostas GI, Seo SW, Cho H, Seong JK, Jeon HJ. Reduced orbitofrontal-thalamic functional connectivity related to suicidal ideation in patients with major depressive disorder. Sci Rep. 2017 Nov 17; 7(1):15772. PMID: 29150619.
    View in: PubMed
  19. Mischoulon D, Hylek L, Yeung AS, Clain AJ, Baer L, Cusin C, Ionescu DF, Alpert JE, Soskin DP, Fava M. Corrigendum to "Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants" [J. Affect. Disord. 208 (2017, Jan. 15) 6-14, doi: 10.1016/j.jad.2016.08.029, Epub 2016 Oct. 1]. J Affect Disord. 2018 02; 227:198. PMID: 29100152.
    View in: PubMed
  20. Choi KW, Na EJ, Hong JP, Cho MJ, Fava M, Mischoulon D, Cho H, Jeon HJ. Alcohol-induced disinhibition is associated with impulsivity, depression, and suicide attempt: A nationwide community sample of Korean adults. J Affect Disord. 2018 02; 227:323-329. PMID: 29132075.
    View in: PubMed
  21. Fava M, Freeman MP, Flynn M, Hoeppner BB, Shelton R, Iosifescu DV, Murrough JW, Mischoulon D, Cusin C, Rapaport M, Dunlop BW, Trivedi MH, Jha M, Sanacora G, Hermes G, Papakostas GI. Double-blind, proof-of-concept (POC) trial of Low-Field Magnetic Stimulation (LFMS) augmentation of antidepressant therapy in treatment-resistant depression (TRD). Brain Stimul. 2018 Jan - Feb; 11(1):75-84. PMID: 29030111.
    View in: PubMed
  22. Lee HK, Kim JH, Fava M, Mischoulon D, Park JH, Shim EJ, Lee EH, Lee JH, Jeon HJ. Development and validation study of the Smartphone Overuse Screening Questionnaire. Psychiatry Res. 2017 11; 257:352-357. PMID: 28800515.
    View in: PubMed
  23. Caldieraro MA, McKee M, Leistner-Segal S, Vares EA, Kubaski F, Spanemberg L, Brusius-Facchin AC, Fleck MP, Mischoulon D. Val66Met polymorphism association with serum BDNF and inflammatory biomarkers in major depression. World J Biol Psychiatry. 2018 08; 19(5):402-409. PMID: 28656803.
    View in: PubMed
  24. Heo JY, Yi H, Fava M, Mischoulon D, Kim K, Yoon S, Jeon HJ, Lee JE. Agoraphobia and Follicle-Stimulating Hormone Levels between Tamoxifen and Goserelin versus Tamoxifen Alone in Premenopausal Hormone Receptor-Positive Breast Cancer: A 12-Month Prospective Randomized Study. Psychiatry Investig. 2017 Jul; 14(4):491-498. PMID: 28845177.
    View in: PubMed
  25. Kim DJ, Kim K, Lee HW, Hong JP, Cho MJ, Fava M, Mischoulon D, Heo JY, Jeon HJ. Internet Game Addiction, Depression, and Escape From Negative Emotions in Adulthood: A Nationwide Community Sample of Korea. J Nerv Ment Dis. 2017 Jul; 205(7):568-573. PMID: 28598958.
    View in: PubMed
  26. Yuan H, Mischoulon D, Fava M, Otto MW. Circulating microRNAs as biomarkers for depression: Many candidates, few finalists. J Affect Disord. 2018 06; 233:68-78. PMID: 28673667.
    View in: PubMed
  27. Sharma A, Gerbarg P, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, Muskin PR, Brown RP, Mischoulon D. S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research. J Clin Psychiatry. 2017 Jun; 78(6):e656-e667. PMID: 28682528.
    View in: PubMed
  28. Kim K, Lee H, Hong JP, Cho MJ, Fava M, Mischoulon D, Kim DJ, Jeon HJ. Poor sleep quality and suicide attempt among adults with internet addiction: A nationwide community sample of Korea. PLoS One. 2017; 12(4):e0174619. PMID: 28384238.
    View in: PubMed
  29. Mischoulon D, Shelton RC, Baer L, Bobo WV, Curren L, Fava M, Papakostas GI. Ziprasidone Augmentation of Escitalopram for Major Depressive Disorder: Cardiac, Endocrine, Metabolic, and Motoric Effects in a Randomized, Double-Blind, Placebo-Controlled Study. J Clin Psychiatry. 2017 04; 78(4):449-455. PMID: 27835715.
    View in: PubMed
  30. Freeman MP, Pooley J, Flynn MJ, Baer L, Mischoulon D, Mou D, Fava M. Guarding the Gate: Remote Structured Assessments to Enhance Enrollment Precision in Depression Trials. J Clin Psychopharmacol. 2017 Apr; 37(2):176-181. PMID: 28187008.
    View in: PubMed
  31. Cusin C, Ionescu DF, Pavone KJ, Akeju O, Cassano P, Taylor N, Eikermann M, Durham K, Swee MB, Chang T, Dording C, Soskin D, Kelley J, Mischoulon D, Brown EN, Fava M. Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation. Aust N Z J Psychiatry. 2017 Jan; 51(1):55-64. PMID: 26893373.
    View in: PubMed
  32. Baek JH, Kim JH, Kim BN, Park SJ, Fava M, Mischoulon D, Lee D, Jeon HJ. Comparisons of Subthreshold Versus Full Posttraumatic Stress Disorder Distinguished by Subjective Functional Impairment Among Train Drivers: A Population-Based Nationwide Study in South Korea. Psychiatry Investig. 2017 Jan; 14(1):1-7. PMID: 28096868.
    View in: PubMed
  33. Heo JY, Kim K, Fava M, Mischoulon D, Papakostas GI, Kim MJ, Kim DJ, Chang KJ, Oh Y, Yu BH, Jeon HJ. Effects of smartphone use with and without blue light at night in healthy adults: A randomized, double-blind, cross-over, placebo-controlled comparison. J Psychiatr Res. 2017 04; 87:61-70. PMID: 28017916.
    View in: PubMed
  34. Jeon HJ, Woo JM, Kim HJ, Fava M, Mischoulon D, Cho SJ, Chang SM, Park DH, Kim JW, Yoo I, Heo JY, Hong JP. Gender Differences in Somatic Symptoms and Current Suicidal Risk in Outpatients with Major Depressive Disorder. Psychiatry Investig. 2016 Nov; 13(6):609-615. PMID: 27909451.
    View in: PubMed
  35. Greenberg J, Shapero BG, Mischoulon D, Lazar SW. Mindfulness-based cognitive therapy for depressed individuals improves suppression of irrelevant mental-sets. Eur Arch Psychiatry Clin Neurosci. 2017 Apr; 267(3):277-282. PMID: 27830339.
    View in: PubMed
  36. Mischoulon D, Hylek L, Yeung AS, Clain AJ, Baer L, Cusin C, Ionescu DF, Alpert JE, Soskin DP, Fava M. Randomized, proof-of-concept trial of low dose naltrexone for patients with breakthrough symptoms of major depressive disorder on antidepressants. J Affect Disord. 2017 01 15; 208:6-14. PMID: 27736689.
    View in: PubMed
  37. Cassano P, Bui E, Rogers AH, Walton ZE, Ross R, Zeng M, Nadal-Vicens M, Mischoulon D, Baker AW, Keshaviah A, Worthington J, Hoge EA, Alpert J, Fava M, Wong KK, Simon NM. Inflammatory cytokines in major depressive disorder: A case-control study. Aust N Z J Psychiatry. 2017 Jan; 51(1):23-31. PMID: 27313138.
    View in: PubMed
  38. Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM, Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients. Mol Psychiatry. 2016 10; 21(10):1483-4. PMID: 27528461.
    View in: PubMed
  39. Chang KJ, Kim K, Fava M, Mischoulon D, Hong JP, Kim DJ, Heo JY, Choi H, Jeon HJ. Cross-national differences in hypochondriasis symptoms between Korean and American outpatients with major depressive disorder. Psychiatry Res. 2016 11 30; 245:127-132. PMID: 27541348.
    View in: PubMed
  40. Mischoulon D, Zajecka J, Freeman MP, Fava M. Does folic acid interfere with lamotrigine? Lancet Psychiatry. 2016 Aug; 3(8):704-5. PMID: 27475760.
    View in: PubMed
  41. de Jong M, Lazar SW, Hug K, Mehling WE, Hölzel BK, Sack AT, Peeters F, Ashih H, Mischoulon D, Gard T. Effects of Mindfulness-Based Cognitive Therapy on Body Awareness in Patients with Chronic Pain and Comorbid Depression. Front Psychol. 2016; 7:967. PMID: 27445929; PMCID: PMC4927571.
    View in: PubMed, PubMed Central
  42. Myung W, Han CE, Fava M, Mischoulon D, Papakostas GI, Heo JY, Kim KW, Kim ST, Kim DJ, Kim DK, Seo SW, Seong JK, Jeon HJ. Reduced frontal-subcortical white matter connectivity in association with suicidal ideation in major depressive disorder. Transl Psychiatry. 2016 06 07; 6(6):e835. PMID: 27271861; PMCID: PMC4931608.
    View in: PubMed, PubMed Central
  43. Yoo HJ, Hong JP, Cho MJ, Fava M, Mischoulon D, Heo JY, Kim K, Jeon HJ. Lifetime suicidal ideation and attempt in adults with full major depressive disorder versus sustained depressed mood. J Affect Disord. 2016 10; 203:275-280. PMID: 27314814.
    View in: PubMed
  44. Ionescu DF, Swee MB, Pavone KJ, Taylor N, Akeju O, Baer L, Nyer M, Cassano P, Mischoulon D, Alpert JE, Brown EN, Nock MK, Fava M, Cusin C. Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study. J Clin Psychiatry. 2016 06; 77(6):e719-25. PMID: 27232360.
    View in: PubMed
  45. Baek JH, Kim HJ, Fava M, Mischoulon D, Papakostas GI, Nierenberg A, Heo JY, Jeon HJ. Reduced Venous Blood Basophil Count and Anxious Depression in Patients with Major Depressive Disorder. Psychiatry Investig. 2016 May; 13(3):321-6. PMID: 27247599; PMCID: PMC4878967.
    View in: PubMed, PubMed Central
  46. Sarris J, Murphy J, Mischoulon D, Papakostas GI, Fava M, Berk M, Ng CH. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. Am J Psychiatry. 2016 Jun 01; 173(6):575-87. PMID: 27113121.
    View in: PubMed
  47. Fava M, Johe K, Ereshefsky L, Gertsik LG, English BA, Bilello JA, Thurmond LM, Johnstone J, Dickerson BC, Makris N, Hoeppner BB, Flynn M, Mischoulon D, Kinrys G, Freeman MP. A Phase 1B, randomized, double blind, placebo controlled, multiple-dose escalation study of NSI-189 phosphate, a neurogenic compound, in depressed patients. Mol Psychiatry. 2016 10; 21(10):1372-80. PMID: 26643541.
    View in: PubMed
  48. Kim K, Hong JP, Cho MJ, Fava M, Mischoulon D, Lee DW, Heo JY, Jeon HJ. Loss of sexual interest and premenstrual mood change in women with postpartum versus non-postpartum depression: A nationwide community sample of Korean adults. J Affect Disord. 2016 Feb; 191:222-9. PMID: 26682491.
    View in: PubMed
  49. Sarris J, Logan AC, Akbaraly TN, Paul Amminger G, Balanzá-Martínez V, Freeman MP, Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Parletta N, Ramsey D, Rucklidge JJ, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN. International Society for Nutritional Psychiatry Research consensus position statement: nutritional medicine in modern psychiatry. World Psychiatry. 2015 Oct; 14(3):370-1. PMID: 26407799; PMCID: PMC4592666.
    View in: PubMed, PubMed Central
  50. Cassano P, Trinh NH, Chang T, Cusin C, Fisher L, Pedrelli P, Nyer M, Kim DJ, Alpert J, Mischoulon D. Treatment Outcome in Depressed Latinos Predicted by Concomitant Psychosislike Symptoms. J Nerv Ment Dis. 2015 Oct; 203(10):769-73. PMID: 26356091.
    View in: PubMed
  51. Mischoulon D, De Jong MF, Vitolo OV, Cusin C, Dording CM, Yeung AS, Durham K, Parkin SR, Fava M, Dougherty DD. Efficacy and safety of a form of cranial electrical stimulation (CES) as an add-on intervention for treatment-resistant major depressive disorder: A three week double blind pilot study. J Psychiatr Res. 2015 Nov; 70:98-105. PMID: 26424428.
    View in: PubMed
  52. Baek JH, Heo JY, Fava M, Mischoulon D, Nierenberg A, Hong JP, Roh S, Jeon HJ. Anxiety symptoms are linked to new-onset suicidal ideation after six months of follow-up in outpatients with major depressive disorder. J Affect Disord. 2015 Nov 15; 187:183-7. PMID: 26342171.
    View in: PubMed
  53. Cassano P, Cusin C, Mischoulon D, Hamblin MR, De Taboada L, Pisoni A, Chang T, Yeung A, Ionescu DF, Petrie SR, Nierenberg AA, Fava M, Iosifescu DV. Near-Infrared Transcranial Radiation for Major Depressive Disorder: Proof of Concept Study. Psychiatry J. 2015; 2015:352979. PMID: 26356811; PMCID: PMC4556873.
    View in: PubMed, PubMed Central
  54. Williams A, Nakagawa A, Sado M, Fujisawa D, Mischoulon D, Smith F, Mimura M, Sato Y. Comparison of Initial Psychological Treatment Selections by US and Japanese Early-Career Psychiatrists for Patients with Major Depression: A Case Vignette Study. Acad Psychiatry. 2016 Apr; 40(2):235-41. PMID: 26268880; PMCID: PMC4762915.
    View in: PubMed, PubMed Central
  55. Baek JH, Park JI, Ahn J, Roh SW, Heo JY, Fava M, Mischoulon D, Jeon HJ. Review of Suicide Prevention Programs: Massachusetts, United States, in Comparison with Seoul. Psychiatry Investig. 2015 Jul; 12(3):281-7. PMID: 26207119; PMCID: PMC4504908.
    View in: PubMed, PubMed Central
  56. Yoo I, Woo JM, Lee SH, Fava M, Mischoulon D, Papakostas GI, Kim EJ, Chung S, Ha JH, Jeon HJ. Influence of anxiety symptoms on improvement of neurocognitive functions in patients with major depressive disorder: A 12-week, multicenter, randomized trial of tianeptine versus escitalopram, the CAMPION study. J Affect Disord. 2015 Oct 01; 185:24-30. PMID: 26142691.
    View in: PubMed
  57. Myung W, Lee GH, Won HH, Fava M, Mischoulon D, Nyer M, Kim DK, Heo JY, Jeon HJ. Paraquat prohibition and change in the suicide rate and methods in South Korea. PLoS One. 2015; 10(6):e0128980. PMID: 26035175; PMCID: PMC4452788.
    View in: PubMed, PubMed Central
  58. Mischoulon D. Novel approaches to study design and intervention for residual symptoms of MDD. J Clin Psychiatry. 2015 Jun; 76(6):e815-7. PMID: 26132691.
    View in: PubMed
  59. Sarris J, Price LH, Carpenter LL, Tyrka AR, Ng CH, Papakostas GI, Jaeger A, Fava M, Mischoulon D. Is S-Adenosyl Methionine (SAMe) for Depression Only Effective in Males? A Re-Analysis of Data from a Randomized Clinical Trial. Pharmacopsychiatry. 2015 Jul; 48(4-5):141-4. PMID: 26011569.
    View in: PubMed
  60. Nyer M, Mischoulon D, Alpert JE, Holt DJ, Brill CD, Yeung A, Pedrelli P, Baer L, Dording C, Huz I, Fisher L, Fava M, Farabaugh A. College students with depressive symptoms with and without fatigue: Differences in functioning, suicidality, anxiety, and depressive severity. Ann Clin Psychiatry. 2015 May; 27(2):100-8. PMID: 25954936; PMCID: PMC4539614.
    View in: PubMed, PubMed Central
  61. Dording CM, Schettler PJ, Dalton ED, Parkin SR, Walker RS, Fehling KB, Fava M, Mischoulon D. A double-blind placebo-controlled trial of maca root as treatment for antidepressant-induced sexual dysfunction in women. Evid Based Complement Alternat Med. 2015; 2015:949036. PMID: 25954318; PMCID: PMC4411442.
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  62. Simon NM, Walton ZE, Bui E, Prescott J, Hoge E, Keshaviah A, Schwarz N, Dryman T, Ojserkis RA, Kovachy B, Mischoulon D, Worthington J, De Vivo I, Fava M, Wong KK. Telomere length and telomerase in a well-characterized sample of individuals with major depressive disorder compared to controls. Psychoneuroendocrinology. 2015 Aug; 58:9-22. PMID: 25932992; PMCID: PMC4461511.
    View in: PubMed, PubMed Central
  63. Rapaport MH, Nierenberg AA, Schettler PJ, Kinkead B, Cardoos A, Walker R, Mischoulon D. Inflammation as a predictive biomarker for response to omega-3 fatty acids in major depressive disorder: a proof-of-concept study. Mol Psychiatry. 2016 Jan; 21(1):71-9. PMID: 25802980; PMCID: PMC4581883.
    View in: PubMed, PubMed Central
  64. Myung W, Won HH, Fava M, Mischoulon D, Yeung A, Lee D, Kim DK, Jeon HJ. Celebrity suicides and their differential influence on suicides in the general population: a national population-based study in Korea. Psychiatry Investig. 2015 Apr; 12(2):204-11. PMID: 25866521; PMCID: PMC4390591.
    View in: PubMed, PubMed Central
  65. Sarris J, Logan AC, Akbaraly TN, Amminger GP, Balanzá-Martínez V, Freeman MP, Hibbeln J, Matsuoka Y, Mischoulon D, Mizoue T, Nanri A, Nishi D, Ramsey D, Rucklidge JJ, Sanchez-Villegas A, Scholey A, Su KP, Jacka FN. Nutritional medicine as mainstream in psychiatry. Lancet Psychiatry. 2015 Mar; 2(3):271-4. PMID: 26359904.
    View in: PubMed
  66. Nakagawa A, Williams A, Sado M, Oguchi Y, Mischoulon D, Smith F, Mimura M, Sato Y. Comparison of treatment selections by Japanese and US psychiatrists for major depressive disorder: A case vignette study. Psychiatry Clin Neurosci. 2015 Sep; 69(9):553-62. PMID: 25601043.
    View in: PubMed
  67. Heo JY, Jeon HJ, Fava M, Mischoulon D, Baer L, Clain A, Doorley J, Pisoni A, Papakostas GI. Efficacy of ziprasidone monotherapy in patients with anxious depression: a 12-week, randomized, double-blind, placebo-controlled, sequential-parallel comparison trial. J Psychiatr Res. 2015 Mar; 62:56-61. PMID: 25659187.
    View in: PubMed
  68. Mischoulon D, Nierenberg AA, Schettler PJ, Kinkead BL, Fehling K, Martinson MA, Hyman Rapaport M. A double-blind, randomized controlled clinical trial comparing eicosapentaenoic acid versus docosahexaenoic acid for depression. J Clin Psychiatry. 2015 Jan; 76(1):54-61. PMID: 25272149.
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  69. Chen JA, Vijapura S, Papakostas GI, Parkin SR, Kim DJ, Cusin C, Baer L, Clain AJ, Fava M, Mischoulon D. Association between physician beliefs regarding assigned treatment and clinical response: re-analysis of data from the Hypericum Depression Trial Study Group. Asian J Psychiatr. 2015 Feb; 13:23-9. PMID: 25544195; PMCID: PMC4518843.
    View in: PubMed, PubMed Central
  70. Jeon HJ, Lee C, Fava M, Mischoulon D, Shim EJ, Heo JY, Choi H, Park JH. Childhood trauma, parental death, and their co-occurrence in relation to current suicidality risk in adults: a nationwide community sample of Korea. J Nerv Ment Dis. 2014 Dec; 202(12):870-6. PMID: 25370752.
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  71. Jeon HJ, Kim JH, Kim BN, Park SJ, Fava M, Mischoulon D, Kang EH, Roh S, Lee D. Sleep quality, posttraumatic stress, depression, and human errors in train drivers: a population-based nationwide study in South Korea. Sleep. 2014 Dec 01; 37(12):1969-75. PMID: 25325495; PMCID: PMC4548517.
    View in: PubMed, PubMed Central
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  90. Cassano P, Chang T, Trinh NH, Baer L, Fava M, Mischoulon D. Differential impact of isolated psychotic symptoms on treatment outcome of major depressive disorder in the STAR*D cohort of Whites, Blacks and Latinos. J Affect Disord. 2013 Sep 05; 150(2):578-84. PMID: 23489398.
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  103. Jeon HJ, Kang ES, Lee EH, Jeong EG, Jeon JR, Mischoulon D, Lee D. Childhood trauma and platelet brain-derived neurotrophic factor (BDNF) after a three month follow-up in patients with major depressive disorder. J Psychiatr Res. 2012 Jul; 46(7):966-72. PMID: 22551661.
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  135. Miller KK, Perlis RH, Papakostas GI, Mischoulon D, Losifescu DV, Brick DJ, Fava M. Low-dose transdermal testosterone augmentation therapy improves depression severity in women. CNS Spectr. 2009 Dec; 14(12):688-94. PMID: 20394176; PMCID: PMC4081446.
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  136. Mischoulon D, Pedrelli P, Wurtman J, Vangel M, Wurtman R. Report of two double-blind randomized placebo-controlled pilot studies of a carbohydrate-rich nutrient mixture for treatment of seasonal affective disorder (SAD). CNS Neurosci Ther. 2010; 16(1):13-24. PMID: 19769596.
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  138. Mischoulon D, Papakostas GI, Dording CM, Farabaugh AH, Sonawalla SB, Agoston AM, Smith J, Beaumont EC, Dahan LE, Alpert JE, Nierenberg AA, Fava M. A double-blind, randomized controlled trial of ethyl-eicosapentaenoate for major depressive disorder. J Clin Psychiatry. 2009 Dec; 70(12):1636-44. PMID: 19709502; PMCID: PMC2918427.
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  140. Fava M, Mischoulon D. Folate in depression: efficacy, safety, differences in formulations, and clinical issues. J Clin Psychiatry. 2009; 70 Suppl 5:12-7. PMID: 19909688.
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  150. Mischoulon D. Update and critique of natural remedies as antidepressant treatments. Psychiatr Clin North Am. 2007 Mar; 30(1):51-68. PMID: 17362803.
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  151. Mischoulon D, Raab MF. The role of folate in depression and dementia. J Clin Psychiatry. 2007; 68 Suppl 10:28-33. PMID: 17900207.
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  156. Fraguas R, Papakostas GI, Mischoulon D, Bottiglieri T, Alpert J, Fava M. Anger attacks in major depressive disorder and serum levels of homocysteine. Biol Psychiatry. 2006 Aug 01; 60(3):270-4. PMID: 16325154.
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  157. Mischoulon D, Lagomasino IT, Harmon C. Atypical psychotic symptoms in a Hispanic population: diagnostic dilemmas and implications for treatment. Psychiatry (Edgmont). 2005 Oct; 2(10):38-46. PMID: 21120089; PMCID: PMC2993517.
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  158. Fava M, Alpert J, Nierenberg AA, Mischoulon D, Otto MW, Zajecka J, Murck H, Rosenbaum JF. A Double-blind, randomized trial of St John's wort, fluoxetine, and placebo in major depressive disorder. J Clin Psychopharmacol. 2005 Oct; 25(5):441-7. PMID: 16160619.
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  159. Iosifescu DV, Nierenberg AA, Mischoulon D, Perlis RH, Papakostas GI, Ryan JL, Alpert JE, Fava M. An open study of triiodothyronine augmentation of selective serotonin reuptake inhibitors in treatment-resistant major depressive disorder. J Clin Psychiatry. 2005 Aug; 66(8):1038-42. PMID: 16086620.
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  160. Farabaugh A, Fava M, Mischoulon D, Sklarsky K, Petersen T, Alpert J. Relationships between major depressive disorder and comorbid anxiety and personality disorders. Compr Psychiatry. 2005 Jul-Aug; 46(4):266-71. PMID: 16175757.
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  161. Papakostas GI, Petersen T, Lebowitz BD, Mischoulon D, Ryan JL, Nierenberg AA, Bottiglieri T, Alpert JE, Rosenbaum JF, Fava M. The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol. 2005 Dec; 8(4):523-8. PMID: 15877935.
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  162. Farabaugh A, Mischoulon D, Fava M, Wu SL, Mascarini A, Tossani E, Alpert JE. The relationship between early changes in the HAMD-17 anxiety/somatization factor items and treatment outcome among depressed outpatients. Int Clin Psychopharmacol. 2005 Mar; 20(2):87-91. PMID: 15729083.
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  163. Yeung A, Kung WW, Murakami JL, Mischoulon D, Alpert JE, Nierenberg AA, Fava M. Outcomes of recognizing depressed Chinese American patients in primary care. Int J Psychiatry Med. 2005; 35(3):213-24. PMID: 16480237.
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  164. Alpert JE, Papakostas G, Mischoulon D, Worthington JJ, Petersen T, Mahal Y, Burns A, Bottiglieri T, Nierenberg AA, Fava M. S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine. J Clin Psychopharmacol. 2004 Dec; 24(6):661-4. PMID: 15538131.
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  165. Farabaugh AH, Mischoulon D, Fava M, Green C, Guyker W, Alpert J. The potential relationship between levels of perceived stress and subtypes of major depressive disorder (MDD). Acta Psychiatr Scand. 2004 Dec; 110(6):465-70. PMID: 15521832.
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  166. Farabaugh A, Mischoulon D, Fava M, Guyker W, Alpert J. The overlap between personality disorders and major depressive disorder (MDD). Ann Clin Psychiatry. 2004 Oct-Dec; 16(4):217-24. PMID: 15702570.
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  167. Murck H, Fava M, Alpert J, Nierenberg AA, Mischoulon D, Otto MW, Zajecka J, Mannel M, Rosenbaum JF. Hypericum extract in patients with MDD and reversed vegetative signs: re-analysis from data of a double-blind, randomized trial of hypericum extract, fluoxetine, and placebo. Int J Neuropsychopharmacol. 2005 Jun; 8(2):215-21. PMID: 15458612.
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  168. Papakostas GI, Petersen T, Mischoulon D, Green CH, Nierenberg AA, Bottiglieri T, Rosenbaum JF, Alpert JE, Fava M. Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 2: predictors of relapse during the continuation phase of pharmacotherapy. J Clin Psychiatry. 2004 Aug; 65(8):1096-8. PMID: 15323595.
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  169. Papakostas GI, Petersen T, Mischoulon D, Ryan JL, Nierenberg AA, Bottiglieri T, Rosenbaum JF, Alpert JE, Fava M. Serum folate, vitamin B12, and homocysteine in major depressive disorder, Part 1: predictors of clinical response in fluoxetine-resistant depression. J Clin Psychiatry. 2004 Aug; 65(8):1090-5. PMID: 15323594.
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  170. Yeung A, Kung WW, Chung H, Rubenstein G, Roffi P, Mischoulon D, Fava M. Integrating psychiatry and primary care improves acceptability to mental health services among Chinese Americans. Gen Hosp Psychiatry. 2004 Jul-Aug; 26(4):256-60. PMID: 15234819.
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  171. Papakostas GI, Ongür D, Iosifescu DV, Mischoulon D, Fava M. Cholesterol in mood and anxiety disorders: review of the literature and new hypotheses. Eur Neuropsychopharmacol. 2004 Mar; 14(2):135-42. PMID: 15013029.
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  172. Mischoulon D, Beresin EV. "The Matrix": An allegory of the psychoanalytic journey. Acad Psychiatry. 2004; 28(1):71-7. PMID: 15140812.
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  173. Yeung A, Chan R, Mischoulon D, Sonawalla S, Wong E, Nierenberg AA, Fava M. Prevalence of major depressive disorder among Chinese-Americans in primary care. Gen Hosp Psychiatry. 2004 Jan-Feb; 26(1):24-30. PMID: 14757299.
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  174. Mischoulon D, Opitz G, Kelly K, Fava M, Rosenbaum JF. A preliminary open study of the tolerability and effectiveness of nefazodone in major depressive disorder: comparing patients who recently discontinued an SSRI with those on no recent antidepressant treatment. Depress Anxiety. 2004; 19(1):43-50. PMID: 14978785.
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  175. Papakostas GI, Petersen T, Mahal Y, Mischoulon D, Nierenberg AA, Fava M. Quality of life assessments in major depressive disorder: a review of the literature. Gen Hosp Psychiatry. 2004 Jan-Feb; 26(1):13-7. PMID: 14757297.
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  176. Perlis RH, Alpert J, Nierenberg AA, Mischoulon D, Yeung A, Rosenbaum JF, Fava M. Clinical and sociodemographic predictors of response to augmentation, or dose increase among depressed outpatients resistant to fluoxetine 20 mg/day. Acta Psychiatr Scand. 2003 Dec; 108(6):432-8. PMID: 14616224.
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  177. Perlis RH, Mischoulon D, Smoller JW, Wan YJ, Lamon-Fava S, Lin KM, Rosenbaum JF, Fava M. Serotonin transporter polymorphisms and adverse effects with fluoxetine treatment. Biol Psychiatry. 2003 Nov 01; 54(9):879-83. PMID: 14573314.
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  178. Papakostas GI, Petersen T, Mischoulon D, Hughes ME, Alpert JE, Nierenberg AA, Rosenbaum JF, Fava M. Serum cholesterol and serotonergic function in major depressive disorder. Psychiatry Res. 2003 May 30; 118(2):137-45. PMID: 12798978.
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  179. Papakostas GI, Petersen T, Mischoulon D, Hughes ME, Spector AR, Alpert JE, Fava M, Nierenberg AA. Functioning and interpersonal relationships as predictors of response in treatment-resistant depression. Compr Psychiatry. 2003 Jan-Feb; 44(1):44-50. PMID: 12524635.
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  180. Mischoulon D, Dougherty DD, Bottonari KA, Gresham RL, Sonawalla SB, Fischman AJ, Fava M. An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor binding. Psychiatry Res. 2002 Dec 30; 116(3):151-61. PMID: 12477599.
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  181. Matthews JD, Bottonari KA, Polania LM, Mischoulon D, Dording CM, Irvin R, Fava M. An open study of olanzapine and fluoxetine for psychotic major depressive disorder: interim analyses. J Clin Psychiatry. 2002 Dec; 63(12):1164-70. PMID: 12523877.
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  182. Mischoulon D, Fava M. Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence. Am J Clin Nutr. 2002 Nov; 76(5):1158S-61S. PMID: 12420702.
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  183. Dording CM, Mischoulon D, Petersen TJ, Kornbluh R, Gordon J, Nierenberg AA, Rosenbaum JE, Fava M. The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists. Ann Clin Psychiatry. 2002 Sep; 14(3):143-7. PMID: 12585563.
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  184. Farabaugh A, Mischoulon D, Yeung A, Alpert J, Matthews J, Pava J, Fava M. Predictors of stable personality disorder diagnoses in outpatients with remitted depression. J Nerv Ment Dis. 2002 Apr; 190(4):248-56. PMID: 11960086.
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  185. Alpert JE, Mischoulon D, Rubenstein GE, Bottonari K, Nierenberg AA, Fava M. Folinic acid (Leucovorin) as an adjunctive treatment for SSRI-refractory depression. Ann Clin Psychiatry. 2002 Mar; 14(1):33-8. PMID: 12046638.
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  186. Mischoulon D, McColl-Vuolo R, Howarth S, Lagomasino IT, Alpert JE, Nierenberg AA, Fava M. Management of major depression in the primary care setting. Psychother Psychosom. 2001 Mar-Apr; 70(2):103-7. PMID: 11244391.
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  187. Mischoulon D, Fava M. Docosahexanoic acid and omega-3 fatty acids in depression. Psychiatr Clin North Am. 2000 Dec; 23(4):785-94. PMID: 11147247.
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  188. Mischoulon D, Burger JK, Spillmann MK, Worthington JJ, Fava M, Alpert JE. Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression. J Psychosom Res. 2000 Sep; 49(3):183-7. PMID: 11110989.
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  189. Alpert JE, Mischoulon D, Nierenberg AA, Fava M. Nutrition and depression: focus on folate. Nutrition. 2000 Jul-Aug; 16(7-8):544-6. PMID: 10906550.
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  190. Mischoulon D, Nierenberg AA, Kizilbash L, Rosenbaum JF, Fava M. Strategies for managing depression refractory to selective serotonin reuptake inhibitor treatment: a survey of clinicians. Can J Psychiatry. 2000 Jun; 45(5):476-81. PMID: 10900529.
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  191. Mischoulon D. Antidepressants: choices and controversy. Health News. 2000 Jun; 6(6):4-5. PMID: 10865517.
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  192. Mischoulon D, Fava M, Rosenbaum JF. Strategies for augmentation of SSRI treatment: a survey of an academic psychopharmacology practice. Harv Rev Psychiatry. 1999 Mar-Apr; 6(6):322-6. PMID: 10370439.
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  193. Mischoulon D, Rosenbaum JF. The use of natural remedies in psychiatry: a commentary. Harv Rev Psychiatry. 1999 Jan-Feb; 6(5):279-83. PMID: 10372293.
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  194. Rana B, Xie Y, Mischoulon D, Bucher NL, Farmer SR. The DNA binding activity of C/EBP transcription factor is regulated in the G1 phase of the hepatocyte cell cycle. J Biol Chem. 1995 Jul 28; 270(30):18123-32. PMID: 7629124.
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  195. Rana B, Mischoulon D, Xie Y, Bucher NL, Farmer SR. Cell-extracellular matrix interactions can regulate the switch between growth and differentiation in rat hepatocytes: reciprocal expression of C/EBP alpha and immediate-early growth response transcription factors. Mol Cell Biol. 1994 Sep; 14(9):5858-69. PMID: 8065319; PMCID: PMC359112.
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  196. Mischoulon D, Rana B, Kotliar N, Pilch PF, Bucher NL, Farmer SR. Differential regulation of glucose transporter 1 and 2 mRNA expression by epidermal growth factor and transforming growth factor-beta in rat hepatocytes. J Cell Physiol. 1992 Nov; 153(2):288-96. PMID: 1429849.
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  197. Mischoulon D, Rana B, Bucher NL, Farmer SR. Growth-dependent inhibition of CCAAT enhancer-binding protein (C/EBP alpha) gene expression during hepatocyte proliferation in the regenerating liver and in culture. Mol Cell Biol. 1992 Jun; 12(6):2553-60. PMID: 1588957; PMCID: PMC364448.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.