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profileTimothy J. Mitchison, Ph.D.

TitleHasib Sabbagh Professor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Alpert 536, Systems Biology
200 Longwood Ave
Boston MA 02115
Phone617/432-3805
Fax617/432-3702
vCardDownload vCard (login for email)
Other Positions
TitleDeputy Chairman of the Department of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology


Collapse Mentoring 
Collapse completed student projects
Elucidation of Mechanism of Action of Cell Motility Inhibitors in a Wound-Healing Assay
Summer, 05/22/00 - 08/01/00
Using Small Molecules to Perturb and Study Cytoskeletal Function
Summer, 06/01/99 - 08/31/99

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U54HG006097     (SORGER, PETER KARL)Sep 27, 2010 - Jul 31, 2014
NIH/NHGRI
Pharmaco Response Signatures and Disease Mechanism
Role: Principal Investigator

T32GM080177     (MITCHISON, TIMOTHY J)Jul 1, 2010 - Jun 30, 2020
NIH/NIGMS
Harvard Systems Biology Graduate Program
Role: Principal Investigator

P01CA139980     (MITCHISON, TIMOTHY J)Jun 1, 2010 - May 31, 2015
NIH/NCI
Mechanistic Pharmacology of Anti-Mitotics and Apoptosis Regulation
Role: Principal Investigator

RC2HG005693     (GRAY, NATHANAEL SCHIANDER)Sep 30, 2009 - Jul 31, 2011
NIH/NHGRI
Mechanistic Signatures of Drug Responses in Cancer
Role: Co-Principal Investigator

S10RR017795     (MITCHISON, TIMOTHY J)Apr 1, 2004 - Mar 31, 2006
NIH/NCRR
Electron Microscope
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S. Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Mol Biol Cell. 2017 Jul 07; 28(14):1975-1983. PMID: 28468979.
    View in: PubMed
  2. Costigliola N, Ding L, Burckhardt CJ, Han SJ, Gutierrez E, Mota A, Groisman A, Mitchison TJ, Danuser G. Vimentin fibers orient traction stress. Proc Natl Acad Sci U S A. 2017 May 16; 114(20):5195-5200. PMID: 28465431.
    View in: PubMed
  3. Hanley ML, Yoo TY, Sonnett M, Needleman DJ, Mitchison TJ. Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin. Mol Biol Cell. 2017 Jun 01; 28(11):1444-1456. PMID: 28404751.
    View in: PubMed
  4. Shi J, Mitchison TJ. Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic. Endocr Relat Cancer. 2017 Sep; 24(9):T83-T96. PMID: 28249963.
    View in: PubMed
  5. Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X. 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells. Elife. 2017 Feb 28; 6. PMID: 28244368.
    View in: PubMed
  6. Ishihara K, Korolev KS, Mitchison TJ. Physical basis of large microtubule aster growth. Elife. 2016 Nov 28; 5. PMID: 27892852.
    View in: PubMed
  7. Boke E, Mitchison TJ. The balbiani body and the concept of physiological amyloids. Cell Cycle. 2017 Jan 17; 16(2):153-154. PMID: 27736303.
    View in: PubMed
  8. Giedt RJ, Fumene Feruglio P, Pathania D, Yang KS, Kilcoyne A, Vinegoni C, Mitchison TJ, Weissleder R. Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response. Sci Rep. 2016 Sep 09; 6:32985. PMID: 27609668; PMCID: PMC5017129.
  9. Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proc Natl Acad Sci U S A. 2016 Aug 30; 113(35):9810-5. PMID: 27528663; PMCID: PMC5024598 [Available on 02/28/17].
  10. Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ. Amyloid-like Self-Assembly of a Cellular Compartment. Cell. 2016 Jul 28; 166(3):637-650. PMID: 27471966.
    View in: PubMed
  11. Field CM, Pelletier JF, Mitchison TJ. Xenopus extract approaches to studying microtubule organization and signaling in cytokinesis. Methods Cell Biol. 2017; 137:395-435. PMID: 28065319.
    View in: PubMed
  12. Al-Obaidi N, Mitchison TJ, Crews CM, Mayer TU. Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells. ACS Chem Biol. 2016 06 17; 11(6):1544-51. PMID: 27121275; PMCID: PMC4990065.
  13. Groen AC, Mitchison TJ. Purification and Fluorescent Labeling of Tubulin from Xenopus laevis Egg Extracts. Methods Mol Biol. 2016; 1413:35-45. PMID: 27193841.
    View in: PubMed
  14. Florian S, Mitchison TJ. Anti-Microtubule Drugs. Methods Mol Biol. 2016; 1413:403-21. PMID: 27193863.
    View in: PubMed
  15. Son S, Kang JH, Oh S, Kirschner MW, Mitchison TJ, Manalis S. Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis. J Cell Biol. 2015 Nov 23; 211(4):757-63. PMID: 26598613; PMCID: PMC4657169 [Available on 05/23/16].
  16. Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP. The Nuclear Proteome of a Vertebrate. Curr Biol. 2015 Oct 19; 25(20):2663-71. PMID: 26441354; PMCID: PMC4618192 [Available on 10/19/16].
  17. Kuhn H, Sopko R, Coughlin M, Perrimon N, Mitchison T. The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos. Development. 2015 Nov 15; 142(22):3869-78. PMID: 26395483; PMCID: PMC4712880 [Available on 11/15/16].
  18. Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Erratum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 2015 Sep; 11(9):741. PMID: 26284675.
    View in: PubMed
  19. Field CM, Groen AC, Nguyen PA, Mitchison TJ. Spindle-to-cortex communication in cleaving, polyspermic Xenopus eggs. Mol Biol Cell. 2015 Oct 15; 26(20):3628-40. PMID: 26310438; PMCID: PMC4603933.
  20. Mitchison TJ, Ishihara K, Nguyen P, Wühr M. Size Scaling of Microtubule Assemblies in Early Xenopus Embryos. Cold Spring Harb Perspect Biol. 2015 Aug 10; 7(10):a019182. PMID: 26261283.
    View in: PubMed
  21. Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ. In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nat Methods. 2015 Jun; 12(6):577-85. PMID: 25867850; PMCID: PMC4579269.
  22. Krukenberg KA, Kim S, Tan ES, Maliga Z, Mitchison TJ. Extracellular poly(ADP-ribose) is a pro-inflammatory signal for macrophages. Chem Biol. 2015 Apr 23; 22(4):446-52. PMID: 25865309; PMCID: PMC4409933.
  23. Nguyen PA, Field CM, Groen AC, Mitchison TJ, Loose M. Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins. Methods Cell Biol. 2015; 128:223-241. PMID: 25997350; PMCID: PMC4578691.
  24. Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Corrigendum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 2015 Mar; 11(3):235. PMID: 25689338.
    View in: PubMed
  25. Özlü N, Qureshi MH, Toyoda Y, Renard BY, Mollaoglu G, Özkan NE, Bulbul S, Poser I, Timm W, Hyman AA, Mitchison TJ, Steen JA. Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis. EMBO J. 2015 Jan 13; 34(2):251-65. PMID: 25476450; PMCID: PMC4337065.
  26. Ishihara K, Nguyen PA, Groen AC, Field CM, Mitchison TJ. Microtubule nucleation remote from centrosomes may explain how asters span large cells. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):17715-22. PMID: 25468969; PMCID: PMC4273342.
  27. Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R. Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Sci Transl Med. 2014 Nov 05; 6(261):261ra152. PMID: 25378644; PMCID: PMC4330962.
  28. Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 2014 Dec; 10(12):1043-8. PMID: 25344812; PMCID: PMC4232468.
  29. Nguyen PA, Groen AC, Loose M, Ishihara K, Wühr M, Field CM, Mitchison TJ. Spatial organization of cytokinesis signaling reconstituted in a cell-free system. Science. 2014 Oct 10; 346(6206):244-7. PMID: 25301629; PMCID: PMC4281018.
  30. Choi PJ, Mitchison TJ. Quantitative analysis of resistance to natural killer attacks reveals stepwise killing kinetics. Integr Biol (Camb). 2014 Dec; 6(12):1153-61. PMID: 25228316.
    View in: PubMed
  31. Ishihara K, Nguyen PA, Wühr M, Groen AC, Field CM, Mitchison TJ. Organization of early frog embryos by chemical waves emanating from centrosomes. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 05; 369(1650). PMID: 25047608; PMCID: PMC4113098.
  32. Krukenberg KA, Jiang R, Steen JA, Mitchison TJ. Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines. Cell Rep. 2014 Sep 25; 8(6):1808-18. PMID: 25199834; PMCID: PMC4177365.
  33. Mitchison TJ. The engine of microtubule dynamics comes into focus. Cell. 2014 May 22; 157(5):1008-10. PMID: 24855939.
    View in: PubMed
  34. Wang Y, Lee YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, Gray NS, Mitchison TJ, Zhao JJ. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 2014 May 20; 3:e01763. PMID: 24844244; PMCID: PMC4059381.
  35. Field CM, Nguyen PA, Ishihara K, Groen AC, Mitchison TJ. Xenopus egg cytoplasm with intact actin. Methods Enzymol. 2014; 540:399-415. PMID: 24630119.
    View in: PubMed
  36. Groen AC, Ngyuen PA, Field CM, Ishihara K, Mitchison TJ. Glycogen-supplemented mitotic cytosol for analyzing Xenopus egg microtubule organization. Methods Enzymol. 2014; 540:417-33. PMID: 24630120.
    View in: PubMed
  37. Coughlin M, Groen AC, Mitchison TJ. Electron microscopy of microtubule cytoskeleton assembly in vitro. Methods Mol Biol. 2014; 1117:259-71. PMID: 24357367.
    View in: PubMed
  38. Prentice-Mott HV, Chang CH, Mahadevan L, Mitchison TJ, Irimia D, Shah JV. Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):21006-11. PMID: 24324148; PMCID: PMC3876268.
  39. Loose M, Mitchison TJ. The bacterial cell division proteins FtsA and FtsZ self-organize into dynamic cytoskeletal patterns. Nat Cell Biol. 2014 Jan; 16(1):38-46. PMID: 24316672; PMCID: PMC4019675.
  40. Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA. Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. J Cell Biol. 2013 Dec 09; 203(5):801-14. PMID: 24297752; PMCID: PMC3857478.
  41. Mitchison TJ. A question of taste. Mol Biol Cell. 2013 Nov; 24(21):3278-80. PMID: 24174461; PMCID: PMC3814136.
  42. Zidovska A, Weitz DA, Mitchison TJ. Micron-scale coherence in interphase chromatin dynamics. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):15555-60. PMID: 24019504; PMCID: PMC3785772.
  43. Tang Y, Xie T, Florian S, Moerke N, Shamu C, Benes C, Mitchison TJ. Differential determinants of cancer cell insensitivity to antimitotic drugs discriminated by a one-step cell imaging assay. J Biomol Screen. 2013 Oct; 18(9):1062-71. PMID: 23788527; PMCID: PMC3783590.
  44. Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison TJ. Anticancer flavonoids are mouse-selective STING agonists. ACS Chem Biol. 2013 Jul 19; 8(7):1396-401. PMID: 23683494; PMCID: PMC3815523.
  45. Choi PJ, Mitchison TJ. Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6488-93. PMID: 23576740; PMCID: PMC3631668.
  46. Mitchison TJ, Nguyen P, Coughlin M, Groen AC. Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol. Mol Biol Cell. 2013 May; 24(10):1559-73. PMID: 23515222; PMCID: PMC3655816.
  47. Kueh HY, Niethammer P, Mitchison TJ. Maintenance of mitochondrial oxygen homeostasis by cosubstrate compensation. Biophys J. 2013 Mar 19; 104(6):1338-48. PMID: 23528093; PMCID: PMC3602778.
  48. Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD. Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell. 2013 Feb 14; 152(4):768-77. PMID: 23415226; PMCID: PMC3680348.
  49. Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nat Commun. 2013; 4:1504. PMID: 23422672; PMCID: PMC3579506.
  50. Barkauskaite E, Brassington A, Tan ES, Warwicker J, Dunstan MS, Banos B, Lafite P, Ahel M, Mitchison TJ, Ahel I, Leys D. Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities. Nat Commun. 2013; 4:2164. PMID: 23917065; PMCID: PMC3741636.
  51. Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Graduate education. Interdisciplinary graduate training in teaching labs. Science. 2012 Dec 21; 338(6114):1542-3. PMID: 23258877; PMCID: PMC3810400.
  52. Maiuri P, Terriac E, Paul-Gilloteaux P, Vignaud T, McNally K, Onuffer J, Thorn K, Nguyen PA, Georgoulia N, Soong D, Jayo A, Beil N, Beneke J, Lim JC, Sim CP, Chu YS, Jiménez-Dalmaroni A, Joanny JF, Thiery JP, Erfle H, Parsons M, Mitchison TJ, Lim WA, Lennon-Duménil AM, Piel M, Théry M. The first World Cell Race. Curr Biol. 2012 Sep 11; 22(17):R673-5. PMID: 22974990; PMCID: PMC3770281.
  53. Mitchison T, Wühr M, Nguyen P, Ishihara K, Groen A, Field CM. Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells. Cytoskeleton (Hoboken). 2012 Oct; 69(10):738-50. PMID: 22786885; PMCID: PMC3690567.
  54. Kim S, Peshkin L, Mitchison TJ. Vascular disrupting agent drug classes differ in effects on the cytoskeleton. PLoS One. 2012; 7(7):e40177. PMID: 22848372; PMCID: PMC3404093.
  55. Zhang X, Wang W, Bedigian AV, Coughlin ML, Mitchison TJ, Eggert US. Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12485-90. PMID: 22802617; PMCID: PMC3411939.
  56. Tan ES, Krukenberg KA, Mitchison TJ. Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers. Anal Biochem. 2012 Sep 15; 428(2):126-36. PMID: 22743307; PMCID: PMC3414684.
  57. Dumont S, Salmon ED, Mitchison TJ. Deformations within moving kinetochores reveal different sites of active and passive force generation. Science. 2012 Jul 20; 337(6092):355-8. PMID: 22722252; PMCID: PMC3672420.
  58. Hu CK, Ozlü N, Coughlin M, Steen JJ, Mitchison TJ. Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis. Mol Biol Cell. 2012 Jul; 23(14):2702-11. PMID: 22621898; PMCID: PMC3395659.
  59. Nguyen PA, Ishihara K, Wühr M, Mitchison TJ. Pronuclear migration: no attachment? No union, but a futile cycle! Curr Biol. 2012 May 22; 22(10):R409-11. PMID: 22625860.
    View in: PubMed
  60. Hu CK, Coughlin M, Mitchison TJ. Midbody assembly and its regulation during cytokinesis. Mol Biol Cell. 2012 Mar; 23(6):1024-34. PMID: 22278743; PMCID: PMC3302730.
  61. Mitchison TJ. The proliferation rate paradox in antimitotic chemotherapy. Mol Biol Cell. 2012 Jan; 23(1):1-6. PMID: 22210845; PMCID: PMC3248889.
  62. Orth JD, Loewer A, Lahav G, Mitchison TJ. Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell. 2012 Feb; 23(4):567-76. PMID: 22171325; PMCID: PMC3279386.
  63. Kwiatkowski N, Deng X, Wang J, Tan L, Villa F, Santaguida S, Huang HC, Mitchison T, Musacchio A, Gray N. Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. ACS Chem Biol. 2012 Jan 20; 7(1):185-96. PMID: 21992004; PMCID: PMC3262907.
  64. Akhtar A, Fuchs E, Mitchison T, Shaw RJ, St Johnston D, Strasser A, Taylor S, Walczak C, Zerial M. A decade of molecular cell biology: achievements and challenges. Nat Rev Mol Cell Biol. 2011 Sep 23; 12(10):669-74. PMID: 21941276; PMCID: PMC3282063.
  65. Groen AC, Coughlin M, Mitchison TJ. Microtubule assembly in meiotic extract requires glycogen. Mol Biol Cell. 2011 Sep; 22(17):3139-51. PMID: 21737678; PMCID: PMC3164461.
  66. Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Res. 2011 Jul 01; 71(13):4608-16. PMID: 21712408; PMCID: PMC3129392.
  67. Tang Y, Orth JD, Xie T, Mitchison TJ. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Lett. 2011 Nov 01; 310(1):15-24. PMID: 21782324; PMCID: PMC3155259.
  68. Garner EC, Bernard R, Wang W, Zhuang X, Rudner DZ, Mitchison T. Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis. Science. 2011 Jul 08; 333(6039):222-5. PMID: 21636745; PMCID: PMC3235694.
  69. Field CM, Wühr M, Anderson GA, Kueh HY, Strickland D, Mitchison TJ. Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos. J Cell Sci. 2011 Jun 15; 124(Pt 12):2086-95. PMID: 21610091; PMCID: PMC3104037.
  70. Hu CK, Coughlin M, Field CM, Mitchison TJ. KIF4 regulates midzone length during cytokinesis. Curr Biol. 2011 May 24; 21(10):815-24. PMID: 21565503; PMCID: PMC3100440.
  71. Shi J, Zhou Y, Huang HC, Mitchison TJ. Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. Cancer Res. 2011 Jul 01; 71(13):4518-26. PMID: 21546570; PMCID: PMC3129452.
  72. Brangwynne CP, Mitchison TJ, Hyman AA. Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4334-9. PMID: 21368180; PMCID: PMC3060270.
  73. Wühr M, Obholzer ND, Megason SG, Detrich HW, Mitchison TJ. Live imaging of the cytoskeleton in early cleavage-stage zebrafish embryos. Methods Cell Biol. 2011; 101:1-18. PMID: 21550437.
    View in: PubMed
  74. Huang HC, Mitchison TJ, Shi J. Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest. PLoS One. 2010 Dec 21; 5(12):e15724. PMID: 21203573; PMCID: PMC3006339.
  75. Mitchison TJ. Remaining mysteries of the cytoplasm. Mol Biol Cell. 2010 Nov 15; 21(22):3811-2. PMID: 21079024; PMCID: PMC2982103.
  76. Wühr M, Tan ES, Parker SK, Detrich HW, Mitchison TJ. A model for cleavage plane determination in early amphibian and fish embryos. Curr Biol. 2010 Nov 23; 20(22):2040-5. PMID: 21055946; PMCID: PMC3031131.
  77. Kueh HY, Brieher WM, Mitchison TJ. Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover. Biophys J. 2010 Oct 06; 99(7):2153-62. PMID: 20923649; PMCID: PMC3042591.
  78. Huang HC, Shi J, Orth JD, Mitchison TJ. Cell death when the SAC is out of commission. Cell Cycle. 2010 Jun 01; 9(11):2049-50. PMID: 20559025.
    View in: PubMed
  79. Martin DS, Fathi R, Mitchison TJ, Gelles J. FRET measurements of kinesin neck orientation reveal a structural basis for processivity and asymmetry. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5453-8. PMID: 20212149; PMCID: PMC2851760.
  80. Gatlin JC, Matov A, Danuser G, Mitchison TJ, Salmon ED. Directly probing the mechanical properties of the spindle and its matrix. J Cell Biol. 2010 Feb 22; 188(4):481-9. PMID: 20176922; PMCID: PMC2828919.
  81. Mitchison TJ, Mitchison HM. Cell biology: How cilia beat. Nature. 2010 Jan 21; 463(7279):308-9. PMID: 20090745.
    View in: PubMed
  82. Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T. Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules. Mol Biol Cell. 2010 Jan 15; 21(2):323-33. PMID: 19940016; PMCID: PMC2808228.
  83. Huang HC, Shi J, Orth JD, Mitchison TJ. Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell. 2009 Oct 06; 16(4):347-58. PMID: 19800579; PMCID: PMC2758291.
  84. Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. PLoS One. 2009 Oct 05; 4(10):e7339. PMID: 19802393; PMCID: PMC2752188.
  85. Ozlü N, Monigatti F, Renard BY, Field CM, Steen H, Mitchison TJ, Steen JJ. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2010 Feb; 9(2):336-50. PMID: 19786723; PMCID: PMC2830844.
  86. Chang P, Coughlin M, Mitchison TJ. Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Mol Biol Cell. 2009 Nov; 20(21):4575-85. PMID: 19759176; PMCID: PMC2770945.
  87. Dumont S, Mitchison TJ. Force and length in the mitotic spindle. Curr Biol. 2009 Sep 15; 19(17):R749-61. PMID: 19906577; PMCID: PMC2791830.
  88. Kueh HY, Mitchison TJ. Structural plasticity in actin and tubulin polymer dynamics. Science. 2009 Aug 21; 325(5943):960-3. PMID: 19696342; PMCID: PMC2864651.
  89. Charras GT, Mitchison TJ, Mahadevan L. Animal cell hydraulics. J Cell Sci. 2009 Sep 15; 122(Pt 18):3233-41. PMID: 19690051; PMCID: PMC2736862.
  90. Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov. 2009 Jul; 8(7):567-78. PMID: 19568283.
    View in: PubMed
  91. Dumont S, Mitchison TJ. Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Curr Biol. 2009 Jul 14; 19(13):1086-95. PMID: 19540117; PMCID: PMC2722833.
  92. Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED. Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity. Curr Biol. 2009 Jul 28; 19(14):1210-5. PMID: 19540121; PMCID: PMC2752711.
  93. Needleman DJ, Xu Y, Mitchison TJ. Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy. Biophys J. 2009 Jun 17; 96(12):5050-9. PMID: 19527665; PMCID: PMC2712041.
  94. Niethammer P, Grabher C, Look AT, Mitchison TJ. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 2009 Jun 18; 459(7249):996-9. PMID: 19494811; PMCID: PMC2803098.
  95. Wühr M, Mitchison TJ, Field CM. Size and speed go hand in hand in cytokinesis. Cell. 2009 May 29; 137(5):798-800. PMID: 19490886.
    View in: PubMed
  96. Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ. Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly. Mol Biol Cell. 2009 Jun; 20(11):2766-73. PMID: 19369413; PMCID: PMC2688555.
  97. Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ. How does a millimeter-sized cell find its center? Cell Cycle. 2009 Apr 15; 8(8):1115-21. PMID: 19282671; PMCID: PMC2880816.
  98. Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED. Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Curr Biol. 2009 Feb 24; 19(4):287-96. PMID: 19230671; PMCID: PMC2709244.
  99. Orth JD, Tang Y, Shi J, Loy CT, Amendt C, Wilm C, Zenke FT, Mitchison TJ. Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol Cancer Ther. 2008 Nov; 7(11):3480-9. PMID: 18974392; PMCID: PMC2597169.
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  105. Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ. A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly. J Cell Sci. 2008 Jul 15; 121(Pt 14):2293-300. PMID: 18559893; PMCID: PMC2902979.
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  108. Niethammer P, Kueh HY, Mitchison TJ. Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm. Curr Biol. 2008 Apr 22; 18(8):586-91. PMID: 18406136; PMCID: PMC2902971.
  109. Salic A, Mitchison TJ. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2415-20. PMID: 18272492; PMCID: PMC2268151.
  110. Mitchison TJ, Charras GT, Mahadevan L. Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Semin Cell Dev Biol. 2008 Jun; 19(3):215-23. PMID: 18395478; PMCID: PMC2696638.
  111. Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol. 2008 Jan; 4(1):59-68. PMID: 18066055.
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  122. Brieher WM, Kueh HY, Ballif BA, Mitchison TJ. Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J Cell Biol. 2006 Oct 23; 175(2):315-24. PMID: 17060499; PMCID: PMC2064572.
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  127. Maliga Z, Mitchison TJ. Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem Biol. 2006 Feb 27; 6:2. PMID: 16504166; PMCID: PMC1448180.
  128. De Wall SL, Painter C, Stone JD, Bandaranayake R, Wiley DC, Mitchison TJ, Stern LJ, DeDecker BS. Noble metals strip peptides from class II MHC proteins. Nat Chem Biol. 2006 Apr; 2(4):197-201. PMID: 16505807.
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  129. Eggert US, Mitchison TJ, Field CM. Animal cytokinesis: from parts list to mechanisms. Annu Rev Biochem. 2006; 75:543-66. PMID: 16756502.
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  133. Mahadevan L, Mitchison TJ. Cell biology: powerful curves. Nature. 2005 Jun 16; 435(7044):895-7. PMID: 15959501.
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  135. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul; 1(2):112-9. PMID: 16408008.
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  137. Mitchison TJ. Mechanism and function of poleward flux in Xenopus extract meiotic spindles. Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29; 360(1455):623-9. PMID: 15897184; PMCID: PMC1569469.
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  139. Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 2005 Mar; 12(3):385-95. PMID: 15797222.
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  140. Perlman ZE, Mitchison TJ, Mayer TU. High-content screening and profiling of drug activity in an automated centrosome-duplication assay. Chembiochem. 2005 Jan; 6(1):145-51. PMID: 15568197.
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  143. Chang P, Jacobson MK, Mitchison TJ. Poly(ADP-ribose) is required for spindle assembly and structure. Nature. 2004 Dec 02; 432(7017):645-9. PMID: 15577915.
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  144. Ramamurthy B, Yengo CM, Straight AF, Mitchison TJ, Sweeney HL. Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry. 2004 Nov 23; 43(46):14832-9. PMID: 15544354.
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  145. Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12; 306(5699):1194-8. PMID: 15539606.
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  146. Shirasu-Hiza M, Perlman ZE, Wittmann T, Karsenti E, Mitchison TJ. Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Curr Biol. 2004 Nov 09; 14(21):1941-5. PMID: 15530396.
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  147. Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R. XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol. 2004 Oct 26; 14(20):1801-11. PMID: 15498487.
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  148. Valentine MT, Perlman ZE, Mitchison TJ, Weitz DA. Mechanical properties of Xenopus egg cytoplasmic extracts. Biophys J. 2005 Jan; 88(1):680-9. PMID: 15501931; PMCID: PMC1305045.
  149. Straight AF, Field CM, Mitchison TJ. Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell. 2005 Jan; 16(1):193-201. PMID: 15496454; PMCID: PMC539163.
  150. Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11; 167(1):19-22. PMID: 15479732; PMCID: PMC2041940.
  151. Eggert US, Kiger AA, Richter C, Perlman ZE, Perrimon N, Mitchison TJ, Field CM. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004 Dec; 2(12):e379. PMID: 15547975; PMCID: PMC528723.
  152. Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM. Bipolarization and poleward flux correlate during Xenopus extract spindle assembly. Mol Biol Cell. 2004 Dec; 15(12):5603-15. PMID: 15385629; PMCID: PMC532038.
  153. Yarrow JC, Perlman ZE, Westwood NJ, Mitchison TJ. A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol. 2004 Sep 09; 4:21. PMID: 15357872; PMCID: PMC521074.
  154. Salic A, Waters JC, Mitchison TJ. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell. 2004 Sep 03; 118(5):567-78. PMID: 15339662.
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  155. Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11821-6. PMID: 15289600; PMCID: PMC511058.
  156. Miller SC, Mitchison TJ. Synthesis and phenotypic screening of a Guanine-mimetic library. Chembiochem. 2004 Jul 05; 5(7):1010-2. PMID: 15239063.
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  157. Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F. Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc Natl Acad Sci U S A. 2004 Jun 15; 101(24):8969-74. PMID: 15184684; PMCID: PMC428456.
  158. Valentine MT, Perlman ZE, Gardel ML, Shin JH, Matsudaira P, Mitchison TJ, Weitz DA. Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. Biophys J. 2004 Jun; 86(6):4004-14. PMID: 15189896; PMCID: PMC1304301.
  159. Carey KL, Westwood NJ, Mitchison TJ, Ward GE. A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7433-8. PMID: 15123807; PMCID: PMC409936.
  160. Brieher WM, Coughlin M, Mitchison TJ. Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. J Cell Biol. 2004 Apr 26; 165(2):233-42. PMID: 15117967; PMCID: PMC2172048.
  161. Ohi R, Sapra T, Howard J, Mitchison TJ. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell. 2004 Jun; 15(6):2895-906. PMID: 15064354; PMCID: PMC420112.
  162. Corcoran LJ, Mitchison TJ, Liu Q. A novel action of histone deacetylase inhibitors in a protein aggresome disease model. Curr Biol. 2004 Mar 23; 14(6):488-92. PMID: 15043813.
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  164. Romberg L, Mitchison TJ. Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division. Biochemistry. 2004 Jan 13; 43(1):282-8. PMID: 14705956.
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  165. Limouze J, Straight AF, Mitchison T, Sellers JR. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil. 2004; 25(4-5):337-41. PMID: 15548862.
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  169. Ohi R, Coughlin ML, Lane WS, Mitchison TJ. An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell. 2003 Aug; 5(2):309-21. PMID: 12919681.
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  170. Xu J, Wang F, Van Keymeulen A, Herzmark P, Straight A, Kelly K, Takuwa Y, Sugimoto N, Mitchison T, Bourne HR. Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell. 2003 Jul 25; 114(2):201-14. PMID: 12887922.
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  171. Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron. 2003 Jul 17; 39(2):217-25. PMID: 12873380.
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  174. Feng Y, Yu S, Lasell TK, Jadhav AP, Macia E, Chardin P, Melancon P, Roth M, Mitchison T, Kirchhausen T. Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6469-74. PMID: 12738886; PMCID: PMC164470.
  175. Shirasu-Hiza M, Coughlin P, Mitchison T. Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification. J Cell Biol. 2003 Apr 28; 161(2):349-58. PMID: 12719474; PMCID: PMC2172913.
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  177. McGrath JL, Eungdamrong NJ, Fisher CI, Peng F, Mahadevan L, Mitchison TJ, Kuo SC. The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol. 2003 Feb 18; 13(4):329-32. PMID: 12593799.
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  194. Degterev A, Lugovskoy A, Cardone M, Mulley B, Wagner G, Mitchison T, Yuan J. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Nat Cell Biol. 2001 Feb; 3(2):173-82. PMID: 11175750.
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  197. Oegema K, Savoian MS, Mitchison TJ, Field CM. Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. J Cell Biol. 2000 Aug 07; 150(3):539-52. PMID: 10931866; PMCID: PMC2175195.
  198. Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chem Biol. 2000 Apr; 7(4):275-86. PMID: 10780927.
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  199. Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. J Cell Biol. 2000 Feb 07; 148(3):519-30. PMID: 10662777; PMCID: PMC2174808.
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  201. Mallavarapu A, Sawin K, Mitchison T. A switch in microtubule dynamics at the onset of anaphase B in the mitotic spindle of Schizosaccharomyces pombe. Curr Biol. 1999 Dec 02; 9(23):1423-6. PMID: 10607565.
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  203. Maddox P, Desai A, Salmon ED, Mitchison TJ, Oogema K, Kapoor T, Matsumoto B, Inoué S. Dynamic confocal imaging of mitochondria in swimming Tetrahymena and of microtubule poleward flux in Xenopus extract spindles. Biol Bull. 1999 Oct; 197(2):263-5. PMID: 10573847.
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  204. Mallavarapu A, Mitchison T. Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retraction. J Cell Biol. 1999 Sep 06; 146(5):1097-106. PMID: 10477762; PMCID: PMC2169471.
  205. Kapoor TM, Mitchison TJ. Allele-specific activators and inhibitors for kinesin. Proc Natl Acad Sci U S A. 1999 Aug 03; 96(16):9106-11. PMID: 10430903; PMCID: PMC17740.
  206. Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol. 1999 Jun; 1(2):75-81. PMID: 10559877; PMCID: PMC2828058.
  207. Oegema K, Wiese C, Martin OC, Milligan RA, Iwamatsu A, Mitchison TJ, Zheng Y. Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. J Cell Biol. 1999 Feb 22; 144(4):721-33. PMID: 10037793; PMCID: PMC2132928.
  208. Sharp DJ, McDonald KL, Brown HM, Matthies HJ, Walczak C, Vale RD, Mitchison TJ, Scholey JM. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J Cell Biol. 1999 Jan 11; 144(1):125-38. PMID: 9885249; PMCID: PMC2148119.
  209. Desai A, Verma S, Mitchison TJ, Walczak CE. Kin I kinesins are microtubule-destabilizing enzymes. Cell. 1999 Jan 08; 96(1):69-78. PMID: 9989498.
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  210. Desai A, Murray A, Mitchison TJ, Walczak CE. The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. Methods Cell Biol. 1999; 61:385-412. PMID: 9891325.
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  211. Frazier JA, Wong ML, Longtine MS, Pringle JR, Mann M, Mitchison TJ, Field C. Polymerization of purified yeast septins: evidence that organized filament arrays may not be required for septin function. J Cell Biol. 1998 Nov 02; 143(3):737-49. PMID: 9813094; PMCID: PMC2148147.
  212. Yoshihara HA, Chiellini G, Mitchison TJ, Scanlan TS. An efficient substitution reaction for the preparation of thyroid hormone analogues. Bioorg Med Chem. 1998 Aug; 6(8):1179-83. PMID: 9784860.
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  213. Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science. 1998 Jul 03; 281(5373):105-8. PMID: 9651243.
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  214. Walczak CE, Vernos I, Mitchison TJ, Karsenti E, Heald R. A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Curr Biol. 1998 Jul 30-Aug 13; 8(16):903-13. PMID: 9707401.
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  215. Desai A, Mitchison TJ. Tubulin and FtsZ structures: functional and therapeutic implications. Bioessays. 1998 Jul; 20(7):523-7. PMID: 9722999.
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  216. Rosenblatt J, Mitchison TJ. Actin, cofilin and cognition. Nature. 1998 Jun 25; 393(6687):739-40. PMID: 9655388.
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  217. Desai A, Maddox PS, Mitchison TJ, Salmon ED. Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles. J Cell Biol. 1998 May 04; 141(3):703-13. PMID: 9566970; PMCID: PMC2132746.
  218. Desai A, Mitchison TJ. Preparation and characterization of caged fluorescein tubulin. Methods Enzymol. 1998; 298:125-32. PMID: 9751877.
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  219. Zheng Y, Wong ML, Alberts B, Mitchison T. Purification and assay of gamma tubulin ring complex. Methods Enzymol. 1998; 298:218-28. PMID: 9751884.
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  220. Welch MD, Mitchison TJ. Purification and assay of the platelet Arp2/3 complex. Methods Enzymol. 1998; 298:52-61. PMID: 9751871.
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  221. Field CM, Oegema K, Zheng Y, Mitchison TJ, Walczak CE. Purification of cytoskeletal proteins using peptide antibodies. Methods Enzymol. 1998; 298:525-41. PMID: 9751906.
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  222. Oegema K, Desai A, Wong ML, Mitchison TJ, Field CM. Purification and assay of a septin complex from Drosophila embryos. Methods Enzymol. 1998; 298:279-95. PMID: 9751888.
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  223. Mitchison TJ, Sawin KE, Theriot JA, Gee K, Mallavarapu A. Caged fluorescent probes. Methods Enzymol. 1998; 291:63-78. PMID: 9661145.
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  224. Desai A, Deacon HW, Walczak CE, Mitchison TJ. A method that allows the assembly of kinetochore components onto chromosomes condensed in clarified Xenopus egg extracts. Proc Natl Acad Sci U S A. 1997 Nov 11; 94(23):12378-83. PMID: 9356457; PMCID: PMC24953.
  225. Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J Cell Biol. 1997 Jul 28; 138(2):375-84. PMID: 9230079; PMCID: PMC2138188.
  226. Oegema K, Mitchison TJ. Rappaport rules: cleavage furrow induction in animal cells. Proc Natl Acad Sci U S A. 1997 May 13; 94(10):4817-20. PMID: 9144146; PMCID: PMC33663.
  227. Rosenblatt J, Agnew BJ, Abe H, Bamburg JR, Mitchison TJ. Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails. J Cell Biol. 1997 Mar 24; 136(6):1323-32. PMID: 9087446; PMCID: PMC2132508.
  228. Cramer LP, Siebert M, Mitchison TJ. Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: implications for the generation of motile force. J Cell Biol. 1997 Mar 24; 136(6):1287-305. PMID: 9087444; PMCID: PMC2132518.
  229. Walczak CE, Verma S, Mitchison TJ. XCTK2: a kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts. J Cell Biol. 1997 Feb 24; 136(4):859-70. PMID: 9049251; PMCID: PMC2132492.
  230. Welch MD, Mallavarapu A, Rosenblatt J, Mitchison TJ. Actin dynamics in vivo. Curr Opin Cell Biol. 1997 Feb; 9(1):54-61. PMID: 9013669.
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  231. Welch MD, Iwamatsu A, Mitchison TJ. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. Nature. 1997 Jan 16; 385(6613):265-9. PMID: 9000076.
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  232. Cramer LP, Mitchison TJ. Investigation of the mechanism of retraction of the cell margin and rearward flow of nodules during mitotic cell rounding. Mol Biol Cell. 1997 Jan; 8(1):109-19. PMID: 9017599; PMCID: PMC276063.
  233. Desai A, Mitchison TJ. Microtubule polymerization dynamics. Annu Rev Cell Dev Biol. 1997; 13:83-117. PMID: 9442869.
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  234. Waters JC, Mitchison TJ, Rieder CL, Salmon ED. The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work. Mol Biol Cell. 1996 Oct; 7(10):1547-58. PMID: 8898361; PMCID: PMC276005.
  235. Walczak CE, Mitchison TJ. Kinesin-related proteins at mitotic spindle poles: function and regulation. Cell. 1996 Jun 28; 85(7):943-6. PMID: 8674121.
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  236. Belmont L, Mitchison T, Deacon HW. Catastrophic revelations about Op18/stathmin. Trends Biochem Sci. 1996 Jun; 21(6):197-8. PMID: 8744350.
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  237. Field CM, al-Awar O, Rosenblatt J, Wong ML, Alberts B, Mitchison TJ. A purified Drosophila septin complex forms filaments and exhibits GTPase activity. J Cell Biol. 1996 May; 133(3):605-16. PMID: 8636235; PMCID: PMC2120824.
  238. Belmont LD, Mitchison TJ. Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell. 1996 Feb 23; 84(4):623-31. PMID: 8598048.
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  239. Mitchison TJ, Cramer LP. Actin-based cell motility and cell locomotion. Cell. 1996 Feb 09; 84(3):371-9. PMID: 8608590.
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  240. Walczak CE, Mitchison TJ, Desai A. XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell. 1996 Jan 12; 84(1):37-47. PMID: 8548824.
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  241. Zheng Y, Wong ML, Alberts B, Mitchison T. Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex. Nature. 1995 Dec 07; 378(6557):578-83. PMID: 8524390.
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  242. Cramer LP, Mitchison TJ. Myosin is involved in postmitotic cell spreading. J Cell Biol. 1995 Oct; 131(1):179-89. PMID: 7559774; PMCID: PMC2120601.
  243. Mitchison TJ. Evolution of a dynamic cytoskeleton. Philos Trans R Soc Lond B Biol Sci. 1995 Sep 29; 349(1329):299-304. PMID: 8577841.
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  244. Hirano T, Mitchison TJ, Swedlow JR. The SMC family: from chromosome condensation to dosage compensation. Curr Opin Cell Biol. 1995 Jun; 7(3):329-36. PMID: 7662362.
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  245. Sawin KE, Mitchison TJ. Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle. Proc Natl Acad Sci U S A. 1995 May 09; 92(10):4289-93. PMID: 7753799; PMCID: PMC41929.
  246. Rosenblatt J, Peluso P, Mitchison TJ. The bulk of unpolymerized actin in Xenopus egg extracts is ATP-bound. Mol Biol Cell. 1995 Feb; 6(2):227-36. PMID: 7787248; PMCID: PMC275831.
  247. Wordeman L, Mitchison TJ. Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J Cell Biol. 1995 Jan; 128(1-2):95-104. PMID: 7822426; PMCID: PMC2120339.
  248. Desai A, Mitchison TJ. A new role for motor proteins as couplers to depolymerizing microtubules. J Cell Biol. 1995 Jan; 128(1-2):1-4. PMID: 7822407; PMCID: PMC2120340.
  249. Hirano T, Mitchison TJ. A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro. Cell. 1994 Nov 04; 79(3):449-58. PMID: 7954811.
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  250. Mitchison TJ. Towards a pharmacological genetics. Chem Biol. 1994 Sep; 1(1):3-6. PMID: 9383364.
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  251. Theriot JA, Rosenblatt J, Portnoy DA, Goldschmidt-Clermont PJ, Mitchison TJ. Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts. Cell. 1994 Feb 11; 76(3):505-17. PMID: 8313471.
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  252. Cramer LP, Mitchison TJ, Theriot JA. Actin-dependent motile forces and cell motility. Curr Opin Cell Biol. 1994 Feb; 6(1):82-6. PMID: 8167030.
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  253. Sawin KE, Mitchison TJ. Microtubule flux in mitosis is independent of chromosomes, centrosomes, and antiparallel microtubules. Mol Biol Cell. 1994 Feb; 5(2):217-26. PMID: 8019007; PMCID: PMC301027.
  254. Murray AW, Mitchison TJ. Mitosis. Kinetochores pass the IQ test. Curr Biol. 1994 Jan 01; 4(1):38-41. PMID: 7922309.
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  255. Theriot JA, Mitchison TJ. The three faces of profilin. Cell. 1993 Dec 03; 75(5):835-8. PMID: 8252619.
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  256. Mitchison TJ. Localization of an exchangeable GTP binding site at the plus end of microtubules. Science. 1993 Aug 20; 261(5124):1044-7. PMID: 8102497.
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  257. Cramer L, Mitchison TJ. Moving and stationary actin filaments are involved in spreading of postmitotic PtK2 cells. J Cell Biol. 1993 Aug; 122(4):833-43. PMID: 8349733; PMCID: PMC2119576.
  258. Hirano T, Mitchison TJ. Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts. J Cell Biol. 1993 Feb; 120(3):601-12. PMID: 8381118; PMCID: PMC2119547.
  259. Hyman AA, Mitchison TJ. An assay for the activity of microtubule-based motors on the kinetochores of isolated Chinese hamster ovary chromosomes. Methods Cell Biol. 1993; 39:267-76. PMID: 8246803.
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  260. Mitchison TJ. Compare and contrast actin filaments and microtubules. Mol Biol Cell. 1992 Dec; 3(12):1309-15. PMID: 1493331; PMCID: PMC275701.
  261. Mitchison TJ, Salmon ED. Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis. J Cell Biol. 1992 Nov; 119(3):569-82. PMID: 1400593; PMCID: PMC2289668.
  262. Sawin KE, LeGuellec K, Philippe M, Mitchison TJ. Mitotic spindle organization by a plus-end-directed microtubule motor. Nature. 1992 Oct 08; 359(6395):540-3. PMID: 1406972.
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  263. Hyman AA, Middleton K, Centola M, Mitchison TJ, Carbon J. Microtubule-motor activity of a yeast centromere-binding protein complex. Nature. 1992 Oct 08; 359(6395):533-6. PMID: 1406970.
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  264. Hyman AA, Salser S, Drechsel DN, Unwin N, Mitchison TJ. Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP. Mol Biol Cell. 1992 Oct; 3(10):1155-67. PMID: 1421572; PMCID: PMC275679.
  265. Theriot JA, Mitchison TJ. Comparison of actin and cell surface dynamics in motile fibroblasts. J Cell Biol. 1992 Oct; 119(2):367-77. PMID: 1400580; PMCID: PMC2289659.
  266. Symons MH, Mitchison TJ. A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts. J Cell Biol. 1992 Sep; 118(5):1235-44. PMID: 1512294; PMCID: PMC2289600.
  267. Theriot JA, Mitchison TJ. The nucleation-release model of actin filament dynamics in cell motility. Trends Cell Biol. 1992 Aug; 2(8):219-22. PMID: 14731477.
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  268. Theriot JA, Mitchison TJ, Tilney LG, Portnoy DA. The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization. Nature. 1992 May 21; 357(6375):257-60. PMID: 1589024.
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  269. Mitchison TJ. Self-organization of polymer-motor systems in the cytoskeleton. Philos Trans R Soc Lond B Biol Sci. 1992 Apr 29; 336(1276):99-106. PMID: 1351302.
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  270. Sawin KE, Mitchison TJ, Wordeman LG. Evidence for kinesin-related proteins in the mitotic apparatus using peptide antibodies. J Cell Sci. 1992 Feb; 101 ( Pt 2):303-13. PMID: 1629247.
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  271. Mitchison TJ. Actin based motility on retraction fibers in mitotic PtK2 cells. Cell Motil Cytoskeleton. 1992; 22(2):135-51. PMID: 1633624.
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  272. Hirano T, Mitchison TJ. Cell cycle control of higher-order chromatin assembly around naked DNA in vitro. J Cell Biol. 1991 Dec; 115(6):1479-89. PMID: 1661728; PMCID: PMC2289196.
  273. Reinsch SS, Mitchison TJ, Kirschner M. Microtubule polymer assembly and transport during axonal elongation. J Cell Biol. 1991 Oct; 115(2):365-79. PMID: 1717484; PMCID: PMC2289149.
  274. Symons MH, Mitchison TJ. Control of actin polymerization in live and permeabilized fibroblasts. J Cell Biol. 1991 Aug; 114(3):503-13. PMID: 1860882; PMCID: PMC2289085.
  275. Theriot JA, Mitchison TJ. Actin microfilament dynamics in locomoting cells. Nature. 1991 Jul 11; 352(6331):126-31. PMID: 2067574.
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  276. Wordeman L, Steuer ER, Sheetz MP, Mitchison T. Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes. J Cell Biol. 1991 Jul; 114(2):285-94. PMID: 1830054; PMCID: PMC2289084.
  277. Hyman AA, Mitchison TJ. Two different microtubule-based motor activities with opposite polarities in kinetochores. Nature. 1991 May 16; 351(6323):206-11. PMID: 2041567.
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  278. Sawin KE, Mitchison TJ. Mitotic spindle assembly by two different pathways in vitro. J Cell Biol. 1991 Mar; 112(5):925-40. PMID: 1999463; PMCID: PMC2288871.
  279. Sawin KE, Mitchison TJ. Poleward microtubule flux mitotic spindles assembled in vitro. J Cell Biol. 1991 Mar; 112(5):941-54. PMID: 1999464; PMCID: PMC2288886.
  280. Hyman A, Drechsel D, Kellogg D, Salser S, Sawin K, Steffen P, Wordeman L, Mitchison T. Preparation of modified tubulins. Methods Enzymol. 1991; 196:478-85. PMID: 2034137.
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  281. Hyman AA, Mitchison TJ. Regulation of the direction of chromosome movement. Cold Spring Harb Symp Quant Biol. 1991; 56:745-50. PMID: 1819521.
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  282. Mitchison TJ. Mitosis. The kinetochore in captivity. Nature. 1990 Nov 01; 348(6296):14-5. PMID: 2234053.
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  283. Belmont LD, Hyman AA, Sawin KE, Mitchison TJ. Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts. Cell. 1990 Aug 10; 62(3):579-89. PMID: 2379239.
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  284. Sawin K, Mitchison T. Cell biology. Motoring in the spindle. Nature. 1990 May 03; 345(6270):22-3. PMID: 2139498.
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  285. Hyman AA, Mitchison TJ. Modulation of microtubule stability by kinetochores in vitro. J Cell Biol. 1990 May; 110(5):1607-16. PMID: 2186046; PMCID: PMC2200175.
  286. Mitchison TJ, Sawin KE. Tubulin flux in the mitotic spindle: where does it come from, where is it going? Cell Motil Cytoskeleton. 1990; 16(2):93-8. PMID: 2198113.
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  287. Mitchison TJ. Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence. J Cell Biol. 1989 Aug; 109(2):637-52. PMID: 2760109; PMCID: PMC2115701.
  288. Chain BM, Mitchison NA, Mitchison TJ, Davies DH, Marcinkiewicz J. Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development. J Autoimmun. 1989 Jun; 2 Suppl:45-53. PMID: 2570591.
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  289. Mitchison TJ. Mitosis: basic concepts. Curr Opin Cell Biol. 1989 Feb; 1(1):67-74. PMID: 2698210.
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  290. Mitchison T, Hyman A. Cell division. Kinetochores on the move. Nature. 1988 Nov 17; 336(6196):200-1. PMID: 3194007.
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  291. Mitchison T, Kirschner M. Cytoskeletal dynamics and nerve growth. Neuron. 1988 Nov; 1(9):761-72. PMID: 3078414.
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  292. Kellogg DR, Mitchison TJ, Alberts BM. Behaviour of microtubules and actin filaments in living Drosophila embryos. Development. 1988 Aug; 103(4):675-86. PMID: 3248521.
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  293. Koshland DE, Mitchison TJ, Kirschner MW. Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature. 1988 Feb 11; 331(6156):499-504. PMID: 3340202.
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  294. Mitchison TJ. Microtubule dynamics and kinetochore function in mitosis. Annu Rev Cell Biol. 1988; 4:527-49. PMID: 3058165.
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  295. Mitchison TJ, Kirschner MW. Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability. Cell Biophys. 1987 Dec; 11:35-55. PMID: 2450668.
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  296. Mitchison TJ. Cell motility: good things from slime. Nature. 1987 Aug 20-26; 328(6132):665. PMID: 2441263.
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  297. Kirschner MW, Mitchison T. Microtubule dynamics. Nature. 1986 Dec 18-31; 324(6098):621. PMID: 3796729.
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  298. Mitchison T, Evans L, Schulze E, Kirschner M. Sites of microtubule assembly and disassembly in the mitotic spindle. Cell. 1986 May 23; 45(4):515-27. PMID: 3708686.
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  299. Kirschner M, Mitchison T. Beyond self-assembly: from microtubules to morphogenesis. Cell. 1986 May 09; 45(3):329-42. PMID: 3516413.
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  300. Kristofferson D, Mitchison T, Kirschner M. Direct observation of steady-state microtubule dynamics. J Cell Biol. 1986 Mar; 102(3):1007-19. PMID: 3005332; PMCID: PMC2114110.
  301. Mitchison TJ, Kirschner MW. Isolation of mammalian centrosomes. Methods Enzymol. 1986; 134:261-8. PMID: 3821566.
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  302. Mitchison TJ. The role of microtubule polarity in the movement of kinesin and kinetochores. J Cell Sci Suppl. 1986; 5:121-8. PMID: 3115997.
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  303. Vale RD, Schnapp BJ, Mitchison T, Steuer E, Reese TS, Sheetz MP. Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell. 1985 Dec; 43(3 Pt 2):623-32. PMID: 2416467.
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  304. Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. J Cell Biol. 1985 Sep; 101(3):766-77. PMID: 4030894; PMCID: PMC2113737.
  305. Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding. J Cell Biol. 1985 Sep; 101(3):755-65. PMID: 4030893; PMCID: PMC2113742.
  306. Evans L, Mitchison T, Kirschner M. Influence of the centrosome on the structure of nucleated microtubules. J Cell Biol. 1985 Apr; 100(4):1185-91. PMID: 4038981; PMCID: PMC2113747.
  307. Leslie RJ, Saxton WM, Mitchison TJ, Neighbors B, Salmon ED, McIntosh JR. Assembly properties of fluorescein-labeled tubulin in vitro before and after fluorescence bleaching. J Cell Biol. 1984 Dec; 99(6):2146-56. PMID: 6438113; PMCID: PMC2113541.
  308. Mitchison T, Kirschner M. Microtubule assembly nucleated by isolated centrosomes. Nature. 1984 Nov 15-21; 312(5991):232-7. PMID: 6504137.
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  309. Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature. 1984 Nov 15-21; 312(5991):237-42. PMID: 6504138.
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  310. Karsenti E, Kobayashi S, Mitchison T, Kirschner M. Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes. J Cell Biol. 1984 May; 98(5):1763-76. PMID: 6725398; PMCID: PMC2113175.
  311. Calarco-Gillam PD, Siebert MC, Hubble R, Mitchison T, Kirschner M. Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Cell. 1983 Dec; 35(3 Pt 2):621-9. PMID: 6652679.
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  312. Mitchison TJ, Sedat J. Localization of antigenic determinants in whole Drosophila embryos. Dev Biol. 1983 Sep; 99(1):261-4. PMID: 6194030.
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  313. Sambrook J, Botchan M, Hu SL, Mitchison T, Stringer J. Integration of viral DNA sequences in cells transformed by adenovirus 2 or SV40. Proc R Soc Lond B Biol Sci. 1980 Nov 19; 210(1180):423-35. PMID: 6109303.
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  314. Botchan M, Stringer J, Mitchison T, Sambrook J. Integration and excision of SV40 DNA from the chromosome of a transformed cell. Cell. 1980 May; 20(1):143-52. PMID: 6248231.
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  315. Sambrook J, Greene R, Stringer J, Mitchison T, Hu SL, Botchan M. Analysis of the sites of integration of viral DNA sequences in rat cells transformed by adenovirus 2 or SV40. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:569-84. PMID: 6253158.
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