Harvard Catalyst Profiles

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Marie Alice Hollenhorst, M.D., Ph.D.

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Stanford University, Stanford, CABS2005Biological Sciences
Harvard University, Cambridge, MAPhD2011Chemical Biology
Harvard Medical School, Boston, MAMD2013Harvard-MIT Health Sciences and Technology (HST) Program
Brigham and Women's Hospital, Boston, MA2016Residency in Internal Medicine
Harvard Medical School, Boston, MA2017Fellowship in Blood Banking and Transfusion Medicine
Stanford University, Stanford, CA2019Fellowship in Hematology
Stanford Fox Award for the Most Outstanding Undergraduate in the Department of Biological Sciences
Harvard Certificate of Distinction in Teaching
Harvard-MIT MD/PhD Program Plaque in Recognition of Exemplary Leadership
International Society for Haemostasis and Thrombosis Oral Abstract Early Career Award


Available: 01/30/23, Expires: 12/31/24

The Hollenhorst laboratory studies glycoproteins that play critical roles in hemostasis and thrombosis (bleeding and clotting). Platelets and coagulation factors are heavily coated in glycans (carbohydrate polymers) which are essential for healthy function of the hemostatic system. We are interested in understanding how these glycans regulate the structure and function of hemostatic glycoproteins, and modulate the anti-platelet immune response. We welcome students who want to perform cutting-edge research using the tools of chemical biology to dissect platelet and coagulation factor glycobiology. Our ultimate goal is to improve the lives of patients with bleeding and thrombotic disorders.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99HL156029 (HOLLENHORST, MARIE) May 15, 2021 - Apr 30, 2023
    Biochemistry of Platelet Desialylation
    Role: Principal Investigator
  2. F32HL149341 (HOLLENHORST, MARIE) Jul 29, 2019 - Jul 28, 2022
    CMP-Neu5Ac: A Central Molecule in Bleeding Diseases and Mediator of a Novel Platelet Effector Function
    Role: Principal Investigator
  3. Early-Career Scientific Research Grant (HOLLENHORST, MARIE) Dec 31, 2022
    National Blood Foundation
    Role: Principal Investigator

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.