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Marie Alice Hollenhorst, M.D., Ph.D.


Stanford University, Stanford, CABS2005Biological Sciences
Harvard University, Cambridge, MAPhD2011Chemical Biology
Harvard Medical School, Boston, MAMD2013Harvard-MIT Health Sciences and Technology (HST) Program
Brigham and Women's Hospital, Boston, MA2016Residency in Internal Medicine
Harvard Medical School, Boston, MA2017Fellowship in Blood Banking and Transfusion Medicine
Stanford University, Stanford, CA2019Fellowship in Hematology
Stanford Fox Award for the Most Outstanding Undergraduate in the Department of Biological Sciences
Harvard Certificate of Distinction in Teaching
Harvard-MIT MD/PhD Program Plaque in Recognition of Exemplary Leadership
International Society for Haemostasis and Thrombosis Oral Abstract Early Career Award


Available: 01/30/23, Expires: 12/31/24

The Hollenhorst laboratory studies glycoproteins that play critical roles in hemostasis and thrombosis (bleeding and clotting). Platelets and coagulation factors are heavily coated in glycans (carbohydrate polymers) which are essential for healthy function of the hemostatic system. We are interested in understanding how these glycans regulate the structure and function of hemostatic glycoproteins, and modulate the anti-platelet immune response. We welcome students who want to perform cutting-edge research using the tools of chemical biology to dissect platelet and coagulation factor glycobiology. Our ultimate goal is to improve the lives of patients with bleeding and thrombotic disorders.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K99HL156029 (HOLLENHORST, MARIE) May 15, 2021 - Apr 30, 2023
    Biochemistry of Platelet Desialylation
    Role: Principal Investigator
  2. F32HL149341 (HOLLENHORST, MARIE) Jul 29, 2019 - Jul 28, 2022
    CMP-Neu5Ac: A Central Molecule in Bleeding Diseases and Mediator of a Novel Platelet Effector Function
    Role: Principal Investigator
  3. Early-Career Scientific Research Grant (HOLLENHORST, MARIE) Dec 31, 2022
    National Blood Foundation
    Role: Principal Investigator

Featured Content

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chongsaritsinsuk J, Steigmeyer AD, Mahoney KE, Rosenfeld MA, Lucas TM, Ince D, Kearns FL, Battison AS, Hollenhorst MA, Shon DJ, Tiemeyer KH, Attah V, Kwon C, Bertozzi CR, Ferracane MJ, Amaro RE, Malaker SA. Glycoproteomic landscape and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE. bioRxiv. 2023 Feb 03. PMID: 36778266; PMCID: PMC9915616.
  2. Hollenhorst MA, Tiemeyer KH, Mahoney KE, Aoki K, Ishihara M, Lowery SC, Rangel-Angarita V, Bertozzi CR, Malaker SA. Comprehensive analysis of platelet glycoprotein Iba ectodomain glycosylation. J Thromb Haemost. 2023 Jan 14. PMID: 36740532.
    Citations: 1     Fields:    
  3. Jajosky RP, Wu SC, Zheng L, Jajosky AN, Jajosky PG, Josephson CD, Hollenhorst MA, Sackstein R, Cummings RD, Arthur CM, Stowell SR. ABO blood group antigens and differential glycan expression: Perspective on the evolution of common human enzyme deficiencies. iScience. 2023 Jan 20; 26(1):105798. PMID: 36691627; PMCID: PMC9860303.
  4. Hollenhorst MA, Goodnough LT. Practical Transfusion Medicine. Restrictive transfusion practice and how to implement it. 2022. View Publication.
  5. Swenson E, Wong LK, Jhaveri P, Weng Y, Kappagoda S, Pandey S, Pritchard A, Rogers A, Ruoss S, Subramanian A, Shan H, Hollenhorst M. Active surveillance of serious adverse events following transfusion of COVID-19 convalescent plasma. Transfusion. 2022 01; 62(1):28-36. PMID: 34677830; PMCID: PMC8661846.
    Citations: 2     Fields:    Translation:Humans
  6. Swenson E, Hollenhorst MA. Dr Judith Graham Pool and the development of cryoprecipitate. Transfusion. 2021 06; 61(6):1676-1677. PMID: 33894065.
    Citations:    Fields:    Translation:Humans
  7. Hollenhorst MA, Braun DA, Burtner CR, Cajigas I, Cunningham-Bussel AC, Eser PÖ, Nabel CS, Tsai FD, Weeks LD, Michel T, Yialamas MA. Bridging the Divide: Student Grand Rounds at the Interface of Basic Science and Clinical Medicine. Acad Med. 2020 04; 95(4):548-552. PMID: 31833852; PMCID: PMC9357424.
    Citations:    Fields:    Translation:Humans
  8. Goodnough LT, Hollenhorst MA. Clinical decision support and improved blood use in patient blood management. Hematology Am Soc Hematol Educ Program. 2019 12 06; 2019(1):577-582. PMID: 31808902; PMCID: PMC6913498.
    Citations: 3     Fields:    Translation:Humans
  9. Hollenhorst MA, Al-Samkari H, Kuter DJ. Markers of autoimmunity in immune thrombocytopenia: prevalence and prognostic significance. Blood Adv. 2019 11 26; 3(22):3515-3521. PMID: 31730698.
    Citations: 7     Fields:    Translation:Humans
  10. Hollenhorst MA, Battinelli EM. Thrombosis, Hypercoagulable States, and Anticoagulants. Prim Care. 2016 Dec; 43(4):619-635. PMID: 27866581.
    Citations: 3     Fields:    Translation:Humans
  11. Hollenhorst MA, Ntai I, Badet B, Kelleher NL, Walsh CT. A head-to-head comparison of eneamide and epoxyamide inhibitors of glucosamine-6-phosphate synthase from the dapdiamide biosynthetic pathway. Biochemistry. 2011 May 17; 50(19):3859-61. PMID: 21520904.
    Citations: 5     Fields:    Translation:Cells
  12. Hollenhorst MA, Bumpus SB, Matthews ML, Bollinger JM, Kelleher NL, Walsh CT. The nonribosomal peptide synthetase enzyme DdaD tethers N(ß)-fumaramoyl-l-2,3-diaminopropionate for Fe(II)/a-ketoglutarate-dependent epoxidation by DdaC during dapdiamide antibiotic biosynthesis. J Am Chem Soc. 2010 Nov 10; 132(44):15773-81. PMID: 20945916.
    Citations: 18     Fields:    Translation:Cells
  13. Hollenhorst MA, Clardy J, Walsh CT. The ATP-dependent amide ligases DdaG and DdaF assemble the fumaramoyl-dipeptide scaffold of the dapdiamide antibiotics. Biochemistry. 2009 Nov 03; 48(43):10467-72. PMID: 19807062.
    Citations: 19     Fields:    Translation:Cells
  14. Smith R, Tarner IH, Hollenhorst M, Lin C, Levicnik AU, Fathman CG, Nolan GP. Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis. Gene Ther. 2003 Aug; 10(15):1248-57. PMID: 12858190.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Anandasabapathy N, Ford GS, Bloom D, Holness C, Paragas V, Seroogy C, Skrenta H, Hollenhorst M, Fathman CG, Soares L. GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. Immunity. 2003 Apr; 18(4):535-47. PMID: 12705856.
    Citations: 124     Fields:    Translation:HumansCells
  16. Goodnough LT, Hollenhorst MA, Nemeth E. Wintrobe’s Clinical Hematology. Iron deficiency and related disorders.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.