Harvard Catalyst Profiles

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David George Harper, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG020654 (HARPER, DAVID G) Sep 30, 2003 - Sep 30, 2006
    Sleep, Circadian Rhythms and Dementing Illnesses
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Heintz HL, Freedberg AL, Harper DG. Dependent Personality in Depressed Older Adults: A Case Report and Systematic Review. J Geriatr Psychiatry Neurol. 2020 Jul 01; 891988720933361. PMID: 32608309.
  2. Weinberg MS, Patrick RE, Schwab NA, Owoyemi P, May R, McManus AJ, Gerber J, Harper DG, Arnold SE, Forester B. Clinical Trials and Tribulations in the COVID-19 Era. Am J Geriatr Psychiatry. 2020 May 19. PMID: 32507686.
  3. Forester BP, Rahman AT, Harper DG, Petrides G. Evolving Evidence for the Efficacy and Safety of ECT for Agitation in Alzheimer Disease. Am J Geriatr Psychiatry. 2020 02; 28(2):164-166. PMID: 31734085.
  4. Forester BP, Patrick RE, Harper DG. Setbacks and Opportunities in Disease-Modifying Therapies in Alzheimer Disease. JAMA Psychiatry. 2019 Sep 18. PMID: 31532462.
  5. Rosmarin DH, Salcone S, Harper D, Forester BP. Spiritual Psychotherapy for Inpatient, Residential, and Intensive Treatment. Am J Psychother. 2019 Sep 01; 72(3):75-83. PMID: 31533453.
  6. Mellen EJ, Harper DG, Ravichandran C, Jensen E, Silveri M, Forester BP. Lamotrigine Therapy and Biomarkers of Cerebral Energy Metabolism in Older Age Bipolar Depression. Am J Geriatr Psychiatry. 2019 08; 27(8):783-793. PMID: 31000323.
  7. Patrick RE, Hobbs K, Mathias L, Harper DG, Forester BP. The Limitations of Using Cognitive Cutoff Scores for Enrollment in Alzheimer Trials. Am J Geriatr Psychiatry. 2019 10; 27(10):1153-1158. PMID: 30982703.
  8. Mathias LK, Monette PJ, Harper DG, Forester BP. Application of magnetic resonance spectroscopy in geriatric mood disorders. Int Rev Psychiatry. 2017 12; 29(6):597-617. PMID: 29199890.
    Citations:    Fields:    Translation:Humans
  9. Jahani S, Fantana AL, Harper D, Ellison JM, Boas DA, Forester BP, Yücel MA. fNIRS can robustly measure brain activity during memory encoding and retrieval in healthy subjects. Sci Rep. 2017 08 25; 7(1):9533. PMID: 28842618.
    Citations: 1     Fields:    
  10. Harper DG, Jensen JE, Ravichandran C, Perlis RH, Fava M, Renshaw PF, Iosifescu DV. Tissue Type-Specific Bioenergetic Abnormalities in Adults with Major Depression. Neuropsychopharmacology. 2017 Mar; 42(4):876-885. PMID: 27585738.
    Citations: 2     Fields:    Translation:Humans
  11. Harper DG, Joe EB, Jensen JE, Ravichandran C, Forester BP. Brain levels of high-energy phosphate metabolites and executive function in geriatric depression. Int J Geriatr Psychiatry. 2016 11; 31(11):1241-1249. PMID: 26891040.
    Citations: 2     Fields:    Translation:Humans
  12. Forester BP, Harper DG, Georgakas J, Ravichandran C, Madurai N, Cohen BM. Antidepressant effects of open label treatment with coenzyme Q10 in geriatric bipolar depression. J Clin Psychopharmacol. 2015 Jun; 35(3):338-40. PMID: 25874916.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  13. Plante DT, Trksak GH, Jensen JE, Penetar DM, Ravichandran C, Riedner BA, Tartarini WL, Dorsey CM, Renshaw PF, Lukas SE, Harper DG. Gray matter-specific changes in brain bioenergetics after acute sleep deprivation: a 31P magnetic resonance spectroscopy study at 4 Tesla. Sleep. 2014 Dec 01; 37(12):1919-27. PMID: 25325507.
    Citations: 4     Fields:    Translation:Humans
  14. Acharya D, Harper DG, Achtyes ED, Seiner SJ, Mahdasian JA, Nykamp LJ, Adkison L, Van der Schuur White L, McClintock SM, Ujkaj M, Davidoff DA, Forester BP. Safety and utility of acute electroconvulsive therapy for agitation and aggression in dementia. Int J Geriatr Psychiatry. 2015 Mar; 30(3):265-73. PMID: 24838521.
    Citations: 2     Fields:    Translation:Humans
  15. Harper DG. Bringing accommodation into focus: the several discoveries of the ciliary muscle. JAMA Ophthalmol. 2014 May; 132(5):645-8. PMID: 24504191.
    Citations: 1     Fields:    Translation:Humans
  16. Woodward MR, Harper DG, Stolyar A, Forester BP, Ellison JM. Dronabinol for the treatment of agitation and aggressive behavior in acutely hospitalized severely demented patients with noncognitive behavioral symptoms. Am J Geriatr Psychiatry. 2014 Apr; 22(4):415-9. PMID: 23597932.
    Citations: 7     Fields:    Translation:Humans
  17. Harper DG, Plante DT, Jensen JE, Ravichandran C, Buxton OM, Benson KL, O'Connor SP, Renshaw PF, Winkelman JW. Energetic and cell membrane metabolic products in patients with primary insomnia: a 31-phosphorus magnetic resonance spectroscopy study at 4 tesla. Sleep. 2013 Apr 01; 36(4):493-500. PMID: 23564996.
    Citations: 9     Fields:    Translation:HumansCells
  18. Harper DG, Jensen JE, Ravichandran C, Sivrioglu Y, Silveri M, Iosifescu DV, Renshaw PF, Forester BP. Tissue-specific differences in brain phosphodiesters in late-life major depression. Am J Geriatr Psychiatry. 2014 May; 22(5):499-509. PMID: 23567437.
    Citations: 3     Fields:    Translation:Humans
  19. Hu K, Harper DG, Shea SA, Stopa EG, Scheer FA. Noninvasive fractal biomarker of clock neurotransmitter disturbance in humans with dementia. Sci Rep. 2013; 3:2229. PMID: 23863985.
    Citations: 12     Fields:    Translation:HumansCells
  20. Volicer L, Harper DG, Stopa EG. Severe impairment of circadian rhythm in Alzheimer's disease. J Nutr Health Aging. 2012 Oct; 16(10):888-90. PMID: 23208027.
    Citations: 3     Fields:    Translation:Humans
  21. Ellison JM, Kyomen HH, Harper DG. Depression in later life: an overview with treatment recommendations. Psychiatr Clin North Am. 2012 Mar; 35(1):203-29. PMID: 22370499.
    Citations: 6     Fields:    Translation:Humans
  22. Forester BP, Zuo CS, Ravichandran C, Harper DG, Du F, Kim S, Cohen BM, Renshaw PF. Coenzyme Q10 effects on creatine kinase activity and mood in geriatric bipolar depression. J Geriatr Psychiatry Neurol. 2012 Mar; 25(1):43-50. PMID: 22467846.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  23. Ujkaj M, Davidoff DA, Seiner SJ, Ellison JM, Harper DG, Forester BP. Safety and efficacy of electroconvulsive therapy for the treatment of agitation and aggression in patients with dementia. Am J Geriatr Psychiatry. 2012 Jan; 20(1):61-72. PMID: 22143072.
    Citations: 9     Fields:    Translation:Humans
  24. Agarwal N, Sung YH, Jensen JE, daCunha G, Harper D, Olson D, Renshaw PF. Short-term administration of uridine increases brain membrane phospholipid precursors in healthy adults: a 31-phosphorus magnetic resonance spectroscopy study at 4T. Bipolar Disord. 2010 Dec; 12(8):825-33. PMID: 21176029.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  25. Berlow YA, Wells WM, Ellison JM, Sung YH, Renshaw PF, Harper DG. Neuropsychiatric correlates of white matter hyperintensities in Alzheimer's disease. Int J Geriatr Psychiatry. 2010 Aug; 25(8):780-8. PMID: 19946864.
    Citations: 15     Fields:    Translation:Humans
  26. Forester BP, Berlow YA, Harper DG, Jensen JE, Lange N, Froimowitz MP, Ravichandran C, Iosifescu DV, Lukas SE, Renshaw PF, Cohen BM. Age-related changes in brain energetics and phospholipid metabolism. NMR Biomed. 2010 Apr; 23(3):242-50. PMID: 19908224.
    Citations: 14     Fields:    Translation:Humans
  27. Forester BP, Harper DG, Jensen JE, Ravichandran C, Jordan B, Renshaw PF, Cohen BM. 31Phosphorus magnetic resonance spectroscopy study of tissue specific changes in high energy phosphates before and after sertraline treatment of geriatric depression. Int J Geriatr Psychiatry. 2009 Aug; 24(8):788-97. PMID: 19382284.
    Citations: 15     Fields:    Translation:Humans
  28. Vimal RL, Pandey-Vimal MU, Vimal LS, Frederick BB, Stopa EG, Renshaw PF, Vimal SP, Harper DG. Activation of suprachiasmatic nuclei and primary visual cortex depends upon time of day. Eur J Neurosci. 2009 Jan; 29(2):399-410. PMID: 19200242.
    Citations: 7     Fields:    Translation:HumansCells
  29. Forester BP, Streeter CC, Berlow YA, Tian H, Wardrop M, Finn CT, Harper D, Renshaw PF, Moore CM. Brain lithium levels and effects on cognition and mood in geriatric bipolar disorder: a lithium-7 magnetic resonance spectroscopy study. Am J Geriatr Psychiatry. 2009 Jan; 17(1):13-23. PMID: 18626002.
    Citations: 11     Fields:    Translation:Humans
  30. Harper DG, Stopa EG, Kuo-Leblanc V, McKee AC, Asayama K, Volicer L, Kowall N, Satlin A. Dorsomedial SCN neuronal subpopulations subserve different functions in human dementia. Brain. 2008 Jun; 131(Pt 6):1609-17. PMID: 18372313.
    Citations: 32     Fields:    Translation:HumansCells
  31. Ellison JM, Harper DG, Berlow Y, Zeranski L. Beyond the "C" in MCI: noncognitive symptoms in amnestic and non-amnestic mild cognitive impairment. CNS Spectr. 2008 Jan; 13(1):66-72. PMID: 18204416.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  32. Klegeris A, Schulzer M, Harper DG, McGeer PL. Increase in core body temperature of Alzheimer's disease patients as a possible indicator of chronic neuroinflammation: a meta-analysis. Gerontology. 2007; 53(1):7-11. PMID: 16940734.
    Citations: 9     Fields:    Translation:Humans
  33. Harper DG, Volicer L, Stopa EG, McKee AC, Nitta M, Satlin A. Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. Am J Geriatr Psychiatry. 2005 May; 13(5):359-68. PMID: 15879584.
    Citations: 37     Fields:    Translation:Humans
  34. Harper DG, Stopa EG, McKee AC, Satlin A, Fish D, Volicer L. Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease. Neurobiol Aging. 2004 Jul; 25(6):771-81. PMID: 15165702.
    Citations: 22     Fields:    Translation:HumansCells
  35. Volicer L, Harper DG, Manning BC, Goldstein R, Satlin A. Sundowning and circadian rhythms in Alzheimer's disease. Am J Psychiatry. 2001 May; 158(5):704-11. PMID: 11329390.
    Citations: 55     Fields:    Translation:Humans
  36. Harper DG, Stopa EG, McKee AC, Satlin A, Harlan PC, Goldstein R, Volicer L. Differential circadian rhythm disturbances in men with Alzheimer disease and frontotemporal degeneration. Arch Gen Psychiatry. 2001 Apr; 58(4):353-60. PMID: 11296096.
    Citations: 40     Fields:    Translation:Humans
  37. Volicer L, Harper DG. Age-related sleep disturbance and body temperature. J Am Geriatr Soc. 1998 Nov; 46(11):1480. PMID: 9809775.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.