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Jay Alan Fishman, M.D.

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Biography
1971
National Merit Scholar
1978 - 1979
Research Honor Prize
1979
Special Student, Clinical Immunology
1983
Travel Grant Award
1986 - 1987
American Foundation for AIDS Research Research Award
1987
Clinical Investigator
1987
Fellowship, MacArthur Foundation for Molecular Parasitology
1988 - 1989
Fellowship
1989
Principal Investigator
1991 - 1992
American Lung Association Research Award
1994
Fellow
1996
Fellow
1999
Power of Distinction
2002
Fujisawa Clinical Career Achievement Award
2003
Councilor
2003
Honorary Member
2004 - 2005
President
2008
Roche Award for Transplant Infectious Disease
2008
University Medal
2009
Martin Research Prize for Excellence in Clinical Research
2014
AST Senior Career Achievement Award in Clinical Transplantation
2023
Thomas E. Starzl State-of-the-Art Lecture: Infection in Transplantation: What Have We Learned From P
2019
Lifetime Achievement Award
2023
KidneyX Prize Competition Winner – Xeno Kidney

Overview
This laboratory has focused on the molecular pathogenesis of infections in immunocompromised hosts. We have isolated and cloned the major surface antigens of the fungal pathogen Pneumocystis carinii. We have studied pathogenesis of infections by the porcine endogenous retrovirus and other porcine viruses to prevent infection in future pig-to-human xenotransplantation, as a model for organ-donor-derived infections. The virus (PERV) has been cloned and quantitative assays developed for this potential pathogen. This approach has been used nationally and internationally in the development of guidelines for screening of organ donors in solid organ transplantation and xenotransplantation including the FDA Advisory Panel on Xenotransplantation, guidelines for Harvard Medical School, US Public Health Service, Health Canada, Institute of Medicine, and World Health Organization.
Clinical investigation has been an outgrowth of the Transplant Infectious Disease Program. Trials of innovative therapies for Pneumocystis infection (atovaquone) in stem cell and solid organ transplantation and of bioavailability of new antiviral agents (ganciclovir) grew directly out of clinical need for such therapies. More recently, we have developed clinical protocols for the national multicenter Clinical Trials in Organ Transplantation to monitor viral infections using novel mutiplexed viral molecular assays, approaches to antimicrobial prophylaxis (ganciclovir, valganciclovir) and therapy (posaconazole) in immunosuppressed hosts, for the harmonization of laboratory assays for viral infections across multiple assay platforms at multiple clinical centers, and for antibody responses to vaccination following heart and kidney transplantation. We have also participated in animal and human trails of the induction of immune tolerance for organ transplantation.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AI163086 (MADSEN, JOREN C) Sep 14, 2021 - Jun 30, 2028
    NIH
    Targeting Inflammation and Alloimmunity in Lung Transplant Recipients With Clazakizumab
    Role: Co-Investigator
  2. U01AI163072 (BRISCOE, DAVID M.) Sep 7, 2021 - Jun 30, 2028
    NIH
    Advancing Transplantation Outcomes in Children
    Role: Co-Investigator
  3. U01AI163087 (NAJI, ALI) Aug 20, 2021 - May 31, 2028
    NIH
    Autologous chimeric antigen receptor engineered T cell immunotherapy for desensitization in patients awaiting kidney transplantation
    Role: Co-Investigator
  4. T32AI007529 (MADSEN, JOREN C) Sep 1, 1998 - Jun 30, 2025
    NIH
    Training in Transplantation Biology
    Role: Co-Investigator
  5. R01HL051957 (FISHMAN, JAY A.) Sep 30, 1993 - Aug 31, 1999
    NIH
    ALVEOLAR MACROPHAGE RESPONSE TO MYCOBACTERIAL CELL WALL
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.