Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Joseph Loscalzo, M.D., Ph.D.

Co-Author

This page shows the publications co-authored by Joseph Loscalzo and Jane Leopold.
Connection Strength

8.291
  1. The application of big data to cardiovascular disease: paths to precision medicine. J Clin Invest. 2020 01 02; 130(1):29-38.
    View in: PubMed
    Score: 0.875
  2. Emerging Role of Precision Medicine in Cardiovascular Disease. Circ Res. 2018 04 27; 122(9):1302-1315.
    View in: PubMed
    Score: 0.779
  3. Oxidative risk for atherothrombotic cardiovascular disease. Free Radic Biol Med. 2009 Dec 15; 47(12):1673-706.
    View in: PubMed
    Score: 0.428
  4. Oxidative mechanisms and atherothrombotic cardiovascular disease. Drug Discov Today Ther Strateg. 2008 Mar; 5(1):5-13.
    View in: PubMed
    Score: 0.385
  5. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med. 2007 Feb; 13(2):189-97.
    View in: PubMed
    Score: 0.358
  6. Oxidative enzymopathies and vascular disease. Arterioscler Thromb Vasc Biol. 2005 Jul; 25(7):1332-40.
    View in: PubMed
    Score: 0.314
  7. Genetic determinants of vascular oxidant stress and endothelial dysfunction. Congest Heart Fail. 2005 Mar-Apr; 11(2):73-9.
    View in: PubMed
    Score: 0.313
  8. Organic nitrate tolerance and endothelial dysfunction: role of folate therapy. Minerva Cardioangiol. 2003 Aug; 51(4):349-59.
    View in: PubMed
    Score: 0.280
  9. Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):32100-6.
    View in: PubMed
    Score: 0.277
  10. Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide. Arterioscler Thromb Vasc Biol. 2003 Mar 01; 23(3):411-7.
    View in: PubMed
    Score: 0.270
  11. Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability. FASEB J. 2001 Aug; 15(10):1771-3.
    View in: PubMed
    Score: 0.244
  12. Diagnosis and Treatment of Right Heart Failure in Pulmonary Vascular Diseases: A National Heart, Lung, and Blood Institute Workshop. Circ Heart Fail. 2021 06; 14(6).
    View in: PubMed
    Score: 0.242
  13. Cyclic strain modulates resistance to oxidant stress by increasing G6PDH expression in smooth muscle cells. . 2000 Nov; 279(5):H2477-85.
    View in: PubMed
    Score: 0.232
  14. Network determinants of cardiovascular calcification and repositioned drug treatments. FASEB J. 2020 08; 34(8):11087-11100.
    View in: PubMed
    Score: 0.227
  15. Clinical importance of understanding vascular biology. Cardiol Rev. 2000 Mar-Apr; 8(2):115-23.
    View in: PubMed
    Score: 0.221
  16. New developments in nitrosovasodilator therapy. Vasc Med. 1997; 2(3):190-202.
    View in: PubMed
    Score: 0.178
  17. Platelet activation by fibrinolytic agents: a potential mechanism for resistance to thrombolysis and reocclusion after successful thrombolysis. Coron Artery Dis. 1995 Dec; 6(12):923-9.
    View in: PubMed
    Score: 0.165
  18. Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation. 2014 Jul 08; 130(2):168-79.
    View in: PubMed
    Score: 0.148
  19. Systems analysis of oxidant stress in the vasculature. IUBMB Life. 2013 Nov; 65(11):911-20.
    View in: PubMed
    Score: 0.143
  20. Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials). Am J Cardiol. 2013 Sep 01; 112(5):720-5.
    View in: PubMed
    Score: 0.139
  21. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification. J Am Heart Assoc. 2012 Dec; 1(6):e003905.
    View in: PubMed
    Score: 0.134
  22. Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study. Eur J Heart Fail. 2013 Mar; 15(3):277-83.
    View in: PubMed
    Score: 0.133
  23. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation. 2012 Aug 21; 126(8):963-74.
    View in: PubMed
    Score: 0.130
  24. Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification. Biochem Biophys Res Commun. 2011 Sep 30; 413(3):436-41.
    View in: PubMed
    Score: 0.123
  25. Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. Circulation. 2011 May 10; 123(18):1963-73.
    View in: PubMed
    Score: 0.120
  26. Reciprocal regulation of 11ß-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro. Mol Cell Biochem. 2011 Jan; 346(1-2):69-79.
    View in: PubMed
    Score: 0.115
  27. Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses. J Biol Chem. 2009 May 01; 284(18):11913-21.
    View in: PubMed
    Score: 0.103
  28. Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. J Biol Chem. 2009 Mar 20; 284(12):7665-72.
    View in: PubMed
    Score: 0.102
  29. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res. 2006 Nov 10; 99(10):1044-59.
    View in: PubMed
    Score: 0.088
  30. Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways. J Biol Chem. 2004 Feb 06; 279(6):4425-32.
    View in: PubMed
    Score: 0.071
  31. Vasoactive substances: nitric oxide and endothelial dysfunction in atherosclerosis. Vascul Pharmacol. 2002 May; 38(5):259-69.
    View in: PubMed
    Score: 0.064
  32. Atherothrombosis: plaque instability and thrombogenesis. Prog Cardiovasc Dis. 2002 Mar-Apr; 44(5):381-94.
    View in: PubMed
    Score: 0.064
  33. NHLBI-CMREF Workshop Report on Pulmonary Vascular Disease Classification: JACC State-of-the-Art Review. J Am Coll Cardiol. 2021 04 27; 77(16):2040-2052.
    View in: PubMed
    Score: 0.060
  34. Roles of endothelial dysfunction in coronary artery disease. Curr Opin Cardiol. 2000 Nov; 15(6):409-15.
    View in: PubMed
    Score: 0.058
  35. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest. 2000 Aug; 106(4):483-91.
    View in: PubMed
    Score: 0.057
  36. Oxidant stress in the vasculature. Curr Atheroscler Rep. 1999 Sep; 1(2):156-64.
    View in: PubMed
    Score: 0.053
  37. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 06 13; 10(445).
    View in: PubMed
    Score: 0.049
  38. Nitric Oxide Alters Human Microvascular Endothelial Cell Response to Cyclic Strain. J Cardiovasc Pharmacol Ther. 1998 Apr; 3(2):135-142.
    View in: PubMed
    Score: 0.048
  39. Network Analysis to Risk Stratify Patients With Exercise Intolerance. Circ Res. 2018 03 16; 122(6):864-876.
    View in: PubMed
    Score: 0.048
  40. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. J Am Heart Assoc. 2016 09 28; 5(10).
    View in: PubMed
    Score: 0.044
  41. Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension. FASEB J. 2016 07; 30(7):2511-27.
    View in: PubMed
    Score: 0.042
  42. Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study. J Heart Lung Transplant. 2016 Mar; 35(3):342-351.
    View in: PubMed
    Score: 0.041
  43. Tumor necrosis factor-a-mediated suppression of dual-specificity phosphatase 4: crosstalk between NF?B and MAPK regulates endothelial cell survival. Mol Cell Biochem. 2013 Oct; 382(1-2):153-62.
    View in: PubMed
    Score: 0.035
  44. Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose. PLoS One. 2012; 7(11):e49128.
    View in: PubMed
    Score: 0.033
  45. Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation. J Biol Chem. 2011 Oct 14; 286(41):35407-35417.
    View in: PubMed
    Score: 0.031
  46. Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression. FASEB J. 2010 Jul; 24(7):2525-32.
    View in: PubMed
    Score: 0.028
  47. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J. 2010 May; 24(5):1497-505.
    View in: PubMed
    Score: 0.027
  48. Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J. 2010 Feb; 24(2):609-16.
    View in: PubMed
    Score: 0.027
  49. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009 Apr; 84(4):221-7.
    View in: PubMed
    Score: 0.026
  50. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 2007 Aug 10; 130(3):427-39.
    View in: PubMed
    Score: 0.023
  51. Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):910-6.
    View in: PubMed
    Score: 0.021
  52. Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ Res. 2006 Feb 03; 98(2):254-61.
    View in: PubMed
    Score: 0.021
  53. Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation. 2005 Jul 12; 112(2):257-63.
    View in: PubMed
    Score: 0.020
  54. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004 Feb 24; 109(7):898-903.
    View in: PubMed
    Score: 0.018
  55. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res. 2003 Jul 25; 93(2):e9-16.
    View in: PubMed
    Score: 0.017
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.