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profileJoseph Loscalzo, M.D., PH.D.

TitleHersey Professor of the Theory and Practice of Physic
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressBrigham and Womens Hospital
Department of Medicine
75 Francis St
Boston MA 02115
Phone617/732-6340
vCardDownload vCard (login for email)
Other Positions
TitleHead of the Department of Medicine at Brigham & Women's Hospital
InstitutionBrigham and Women's Hospital
DepartmentMedicine


Collapse Mentoring 
Collapse completed student projects
Angiotensin II and aldosterone potentially induce vascular smooth muscle cell calcification by decreasing expression of the microRNA-30 family
Summer, 06/03/13 - 01/16/14

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U01HG007690     (LOSCALZO, JOSEPH)Jul 1, 2014 - Mar 31, 2018
NIH/NHGRI
Center for Integrated Approaches to Undiagnosed Diseases
Role: Principal Investigator

U54HL119145     (LOSCALZO, JOSEPH)Sep 26, 2013 - Jul 31, 2020
NIH/NHLBI
Boston Biomedical Innovation Center
Role: Co-Principal Investigator

U01HL108630     (LOSCALZO, JOSEPH)Aug 18, 2011 - Jun 30, 2015
NIH/NHLBI
The Phathophenotype Landscape of Complex Disease
Role: Principal Investigator

P50HL107192     (LOSCALZO, JOSEPH)May 1, 2011 - Apr 30, 2013
NIH/NHLBI
Targeted Delivery of Progenitor Cells to the Lung
Role: Co-Principal Investigator

P01HL081587     (WALSH, KENNETH)Sep 30, 2005 - Feb 29, 2016
NIH/NHLBI
Metabolic Control of Endothelias Cell Phenotype
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tao R, Zhao Y, Chu H, Wang A, Zhu J, Chen X, Zou Y, Shi M, Liu R, Su N, Du J, Zhou HM, Zhu L, Qian X, Liu H, Loscalzo J, Yang Y. Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism. Nat Methods. 2017 Jun 05. PMID: 28581494.
    View in: PubMed
  2. Wang RS, Hall KT, Giulianini F, Passow D, Kaptchuk TJ, Loscalzo J. Network analysis of the genomic basis of the placebo effect. JCI Insight. 2017 Jun 02; 2(11). PMID: 28570268.
    View in: PubMed
  3. Silbersweig D, Loscalzo J. Precision Psychiatry Meets Network Medicine: Network Psychiatry. JAMA Psychiatry. 2017 May 17. PMID: 28514455.
    View in: PubMed
  4. Ramoni RB, Mulvihill JJ, Adams DR, Allard P, Ashley EA, Bernstein JA, Gahl WA, Hamid R, Loscalzo J, McCray AT, Shashi V, Tifft CJ, Wise AL. The Undiagnosed Diseases Network: Accelerating Discovery about Health and Disease. Am J Hum Genet. 2017 Feb 02; 100(2):185-192. PMID: 28157539.
    View in: PubMed
  5. Schulman AR, Tavakkoli A, Thompson CC, Miller AL, Loscalzo J. Making the Connection. N Engl J Med. 2017 02 02; 376(5):476-482. PMID: 28146669.
    View in: PubMed
  6. Armstrong K, Anderson ME, Carethers JM, Loscalzo J, Parmacek MS, Wachter RM, Zeidel ML. International Exchange and American Medicine. N Engl J Med. 2017 May 11; 376(19):e40. PMID: 28146413.
    View in: PubMed
  7. Handy DE, Loscalzo J. Responses to reductive stress in the cardiovascular system. Free Radic Biol Med. 2017 Aug; 109:114-124. PMID: 27940350.
    View in: PubMed
  8. Cheng F, Loscalzo J. Autoimmune Cardiotoxicity of Cancer Immunotherapy. Trends Immunol. 2017 Feb; 38(2):77-78. PMID: 27919707.
    View in: PubMed
  9. Zaman P, Wang J, Blau A, Wang W, Li T, Kohane DS, Loscalzo J, Zhang YY. Incorporation of heparin-binding proteins into preformed dextran sulfate-chitosan nanoparticles. Int J Nanomedicine. 2016; 11:6149-6159. PMID: 27920522.
    View in: PubMed
  10. Mirzakhani H, Litonjua AA, McElrath TF, O'Connor G, Lee-Parritz A, Iverson R, Macones G, Strunk RC, Bacharier LB, Zeiger R, Hollis BW, Handy DE, Sharma A, Laranjo N, Carey V, Qiu W, Santolini M, Liu S, Chhabra D, Enquobahrie DA, Williams MA, Loscalzo J, Weiss ST. Early pregnancy vitamin D status and risk of preeclampsia. J Clin Invest. 2016 Dec 01; 126(12):4702-4715. PMID: 27841759.
    View in: PubMed
  11. Scully EP, Earp BE, Miller AL, Loscalzo J. Just a Cut. N Engl J Med. 2016 Nov 03; 375(18):1780-1786. PMID: 27806242.
    View in: PubMed
  12. Klein JP, Stover DG, Oxnard GR, Levy BD, Loscalzo J. Restoring Balance: Paraneoplastic Cerebellar Degeneration. Am J Med. 2017 Mar; 130(3):e85-e87. PMID: 27816447.
    View in: PubMed
  13. Kitsak M, Sharma A, Menche J, Guney E, Ghiassian SD, Loscalzo J, Barabási AL. Tissue Specificity of Human Disease Module. Sci Rep. 2016 Oct 17; 6:35241. PMID: 27748412.
    View in: PubMed
  14. Massarotti EM, Sax PE, Compton L, Levy BD, Loscalzo J. Testing Limits. N Engl J Med. 2016 Oct 06; 375(14):1383-1388. PMID: 27705260.
    View in: PubMed
  15. Baudrand R, Gupta N, Garza AE, Vaidya A, Leopold JA, Hopkins PN, Jeunemaitre X, Ferri C, Romero JR, Williams J, Loscalzo J, Adler GK, Williams GH, Pojoga LH. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. J Am Heart Assoc. 2016 Sep 28; 5(10). PMID: 27680666.
    View in: PubMed
  16. Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovic M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. Selenoprotein Gene Nomenclature. J Biol Chem. 2016 Nov 11; 291(46):24036-24040. PMID: 27645994.
    View in: PubMed
  17. Zang T, Pottenplackel LP, Handy DE, Loscalzo J, Dai S, Deth RC, Zhou ZS, Ma J. Comparison of Protein N-Homocysteinylation in Rat Plasma under Elevated Homocysteine Using a Specific Chemical Labeling Method. Molecules. 2016 Sep 08; 21(9). PMID: 27617989.
    View in: PubMed
  18. Lampson BL, Gray SW, Cibas ES, Levy BD, Loscalzo J. CLINICAL PROBLEM-SOLVING. Tip of the Tongue. N Engl J Med. 2016 Sep 01; 375(9):880-6. PMID: 27579639.
    View in: PubMed
  19. Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY. Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension. J Clin Invest. 2016 Sep 01; 126(9):3313-35. PMID: 27548520; PMCID: PMC5004943 [Available on 12/01/16].
  20. Oldham WM, Loscalzo J. Quantification of 2-Hydroxyglutarate Enantiomers by Liquid Chromatography-mass Spectrometry. Bio Protoc. 2016 Aug 20; 6(16). PMID: 28573160.
    View in: PubMed
  21. Manrai AK, Funke BH, Rehm HL, Olesen MS, Maron BA, Szolovits P, Margulies DM, Loscalzo J, Kohane IS. Genetic Misdiagnoses and the Potential for Health Disparities. N Engl J Med. 2016 Aug 18; 375(7):655-65. PMID: 27532831.
    View in: PubMed
  22. Loscalzo J. Adaptions to Hypoxia and Redox Stress: Essential Concepts Confounded by Misleading Terminology. Circ Res. 2016 Aug 05; 119(4):511-3. PMID: 27492841; PMCID: PMC4976630 [Available on 08/05/17].
  23. Aday AW, Saavedra AP, Levy BD, Loscalzo J. CLINICAL PROBLEM-SOLVING. Prevention as Precipitant. N Engl J Med. 2016 Aug 04; 375(5):471-5. PMID: 27518666.
    View in: PubMed
  24. Alexander KM, Veillet-Chowdhury MR, MacIntyre CJ, Loscalzo J, Bhatt DL. Response by Alexander et al to Letters Regarding Article, "A Shocking Development in a Young Male Athlete With Chest Pain". Circulation. 2016 Jul 26; 134(4):e22-3. PMID: 27462059.
    View in: PubMed
  25. Gibson CJ, Berliner N, Miller AL, Loscalzo J. CLINICAL PROBLEM-SOLVING. A Bruising Loss. N Engl J Med. 2016 Jul 07; 375(1):76-81. PMID: 27406351.
    View in: PubMed
  26. Zhao Y, Wang A, Zou Y, Su N, Loscalzo J, Yang Y. In vivo monitoring of cellular energy metabolism using SoNar, a highly responsive sensor for NAD(+)/NADH redox state. Nat Protoc. 2016 Aug; 11(8):1345-59. PMID: 27362337.
    View in: PubMed
  27. Antman EM, Loscalzo J. Precision medicine in cardiology. Nat Rev Cardiol. 2016 Oct; 13(10):591-602. PMID: 27356875.
    View in: PubMed
  28. Loscalzo J. Looking Back, Looking Forward: Reflections on Tenure as Editor of Circulation. Circulation. 2016 Jun 21; 133(25):2599-600. PMID: 27324353.
    View in: PubMed
  29. MacRae CA, Loscalzo J. The Future of Cardiovascular Biomedicine. Circulation. 2016 Jun 21; 133(25):2601-2. PMID: 27324354.
    View in: PubMed
  30. MacRae CA, Roden DM, Loscalzo J. The Future of Cardiovascular Therapeutics. Circulation. 2016 Jun 21; 133(25):2610-7. PMID: 27324356.
    View in: PubMed
  31. Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabási AL, Loscalzo J. Endophenotype Network Models: Common Core of Complex Diseases. Sci Rep. 2016 Jun 09; 6:27414. PMID: 27278246; PMCID: PMC4899691.
  32. MacFarlane L, Osman N, Ritter S, Miller AL, Loscalzo J. CLINICAL PROBLEM-SOLVING. Eye of the Beholder. N Engl J Med. 2016 May 05; 374(18):1774-9. PMID: 27144853.
    View in: PubMed
  33. Wang RS, Loscalzo J. Illuminating drug action by network integration of disease genes: a case study of myocardial infarction. Mol Biosyst. 2016 Apr 26; 12(5):1653-66. PMID: 27004607; PMCID: PMC4846559 [Available on 04/26/17].
  34. Loscalzo J. The Future of Medical Journal Publishing: The Journal Editor's Perspective: Looking Back, Looking Forward. Circulation. 2016 Apr 19; 133(16):1621-4. PMID: 27142606.
    View in: PubMed
  35. Aghamohammadzadeh R, Zhang YY, Stephens TE, Arons E, Zaman P, Polach KJ, Matar M, Yung LM, Yu PB, Bowman FP, Opotowsky AR, Waxman AB, Loscalzo J, Leopold JA, Maron BA. Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension. FASEB J. 2016 Jul; 30(7):2511-27. PMID: 27006450; PMCID: PMC4904292 [Available on 07/01/17].
  36. Garmaroudi FS, Handy DE, Liu YY, Loscalzo J. Systems Pharmacology and Rational Polypharmacy: Nitric Oxide-Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case. PLoS Comput Biol. 2016 Mar; 12(3):e1004822. PMID: 26985825; PMCID: PMC4795786.
  37. Alexander KM, Veillet-Chowdhury MR, MacIntyre CJ, Loscalzo J, Bhatt DL. A Shocking Development in a Young Male Athlete With Chest Pain. Circulation. 2016 Feb 23; 133(8):756-63. PMID: 26903018.
    View in: PubMed
  38. Shah SH, Arnett D, Houser SR, Ginsburg GS, MacRae C, Mital S, Loscalzo J, Hall JL. Opportunities for the Cardiovascular Community in the Precision Medicine Initiative. Circulation. 2016 Jan 12; 133(2):226-31. PMID: 27028435.
    View in: PubMed
  39. Mogabgab ON, Osman NY, Wei K, Batal I, Loscalzo J. CLINICAL PROBLEM-SOLVING. A Complementary Affair. N Engl J Med. 2016 Jan 07; 374(1):74-81. PMID: 26735996.
    View in: PubMed
  40. Michel T, Loscalzo J. Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. N Engl J Med. 2015 Oct 29; 373(18):1789. PMID: 26510043.
    View in: PubMed
  41. Barroso M, Kao D, Blom HJ, Tavares de Almeida I, Castro R, Loscalzo J, Handy DE. S-adenosylhomocysteine induces inflammation through NFkB: A possible role for EZH2 in endothelial cell activation. Biochim Biophys Acta. 2016 Jan; 1862(1):82-92. PMID: 26506125; PMCID: PMC4674364 [Available on 01/01/17].
  42. Maron BA, Stephens TE, Farrell LA, Oldham WM, Loscalzo J, Leopold JA, Lewis GD. Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study. J Heart Lung Transplant. 2016 Mar; 35(3):342-51. PMID: 26586488; PMCID: PMC4789151 [Available on 03/01/17].
  43. Rabin AS, Hamnvik OP, Robinson ES, Miller AL, Loscalzo J. CLINICAL PROBLEM-SOLVING. Springing a Leak. N Engl J Med. 2015 Oct; 373(14):1362-7. PMID: 26422727.
    View in: PubMed
  44. Abdalla M, Sax PE, Mostaghimi A, Miller AL, Loscalzo J. CLINICAL PROBLEM-SOLVING. On the Nose. N Engl J Med. 2015 Sep 03; 373(10):955-61. PMID: 26332551.
    View in: PubMed
  45. Oldham WM, Clish CB, Yang Y, Loscalzo J. Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress. Cell Metab. 2015 Aug 04; 22(2):291-303. PMID: 26212716; PMCID: PMC4526408.
  46. Steinhorn BS, Loscalzo J, Michel T. Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. N Engl J Med. 2015 Jul 16; 373(3):277-80. PMID: 26176386; PMCID: PMC4836444.
  47. Geller BJ, Stone RM, Merola JF, Levy BD, Loscalzo J. CLINICAL PROBLEM-SOLVING. A Man with Fever, Cough, and Rash. N Engl J Med. 2015 Jul 02; 373(1):74-80. PMID: 26132944.
    View in: PubMed
  48. Zhao Y, Hu Q, Cheng F, Su N, Wang A, Zou Y, Hu H, Chen X, Zhou HM, Huang X, Yang K, Zhu Q, Wang X, Yi J, Zhu L, Qian X, Chen L, Tang Y, Loscalzo J, Yang Y. SoNar, a Highly Responsive NAD+/NADH Sensor, Allows High-Throughput Metabolic Screening of Anti-tumor Agents. Cell Metab. 2015 May 05; 21(5):777-89. PMID: 25955212; PMCID: PMC4427571.
  49. Joseph J, Loscalzo J. Nutri(meta)genetics and cardiovascular disease: novel concepts in the interaction of diet and genomic variation. Curr Atheroscler Rep. 2015 May; 17(5):505. PMID: 25782777; PMCID: PMC4401039.
  50. Wang RS, Maron BA, Loscalzo J. Systems medicine: evolution of systems biology from bench to bedside. Wiley Interdiscip Rev Syst Biol Med. 2015 Jul-Aug; 7(4):141-61. PMID: 25891169; PMCID: PMC4457580.
  51. Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation. 2015 May 12; 131(19):1715-36. PMID: 25882488; PMCID: PMC4825323.
  52. Hall KT, Loscalzo J, Kaptchuk TJ. Genetics and the placebo effect: the placebome. Trends Mol Med. 2015 May; 21(5):285-94. PMID: 25883069; PMCID: PMC4573548.
  53. Fox CS, Bonaca MA, Ryan JJ, Massaro JM, Barry K, Loscalzo J. Response to letters regarding article, "A randomized trial of social media from Circulation". Circulation. 2015 Mar 31; 131(13):e396. PMID: 25825407.
    View in: PubMed
  54. Schaefer L, Paik JM, Rennke H, Levy BD, Loscalzo J. Clinical problem solving: Itching for a diagnosis. N Engl J Med. 2015 Mar 05; 372(10):964-8. PMID: 25738673.
    View in: PubMed
  55. Menche J, Sharma A, Kitsak M, Ghiassian SD, Vidal M, Loscalzo J, Barabási AL. Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Science. 2015 Feb 20; 347(6224):1257601. PMID: 25700523; PMCID: PMC4435741.
  56. Loscalzo J. Expression of concern. Circulation. 2015 02 17; 131(7):e351. PMID: 25691710.
    View in: PubMed
  57. Keaney JF, Loscalzo J. Joseph A. Vita, MD, 1956-2014. Circulation. 2015 Jan 27; 131(4):432-3. PMID: 25623127; PMCID: PMC4323562.
  58. Keaney JF, Loscalzo J. Joseph A. Vita, MD, 1956-2014. J Am Heart Assoc. 2015 Jan 26; 4(1):e001778. PMID: 25628411; PMCID: PMC4330084.
  59. Hiltunen TP, Donner KM, Sarin AP, Saarela J, Ripatti S, Chapman AB, Gums JG, Gong Y, Cooper-DeHoff RM, Frau F, Glorioso V, Zaninello R, Salvi E, Glorioso N, Boerwinkle E, Turner ST, Johnson JA, Kontula KK. Pharmacogenomics of hypertension: a genome-wide, placebo-controlled cross-over study, using four classes of antihypertensive drugs. J Am Heart Assoc. 2015 Jan 26; 4(1):e001521. PMID: 25622599; PMCID: PMC4330076.
  60. Bader AR, Li T, Wang W, Kohane DS, Loscalzo J, Zhang YY. Preparation and characterization of SDF-1a-chitosan-dextran sulfate nanoparticles. J Vis Exp. 2015 Jan 22; (95):52323. PMID: 25650558; PMCID: PMC4354548.
  61. Loscalzo J. Maintenance of certification: Good intentions gone awry. Trends Cardiovasc Med. 2015 May; 25(4):312-4. PMID: 25618320.
    View in: PubMed
  62. Loscalzo J. Redox Dysregulation in Vascular Pathobiology. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S2. PMID: 26461304.
    View in: PubMed
  63. Drazen JM, Shields HM, Loscalzo J. A division of medical communications in an academic medical center's department of medicine. Acad Med. 2014 Dec; 89(12):1623-9. PMID: 25186816.
    View in: PubMed
  64. Benjamin I, Brown N, Burke G, Correa A, Houser SR, Jones DW, Loscalzo J, Vasan RS, Whitman GR. American Heart Association Cardiovascular Genome-Phenome Study: foundational basis and program. Circulation. 2015 Jan 06; 131(1):100-12. PMID: 25411155; PMCID: PMC4286232.
  65. Fox CS, Bonaca MA, Ryan JJ, Massaro JM, Barry K, Loscalzo J. A randomized trial of social media from Circulation. Circulation. 2015 Jan 06; 131(1):28-33. PMID: 25406308.
    View in: PubMed
  66. Price C, Ashbaugh C, Miller AL, Loscalzo J. Clinical problem-solving. A chilly fever. N Engl J Med. 2014 Nov 06; 371(19):1833-7. PMID: 25372092.
    View in: PubMed
  67. Tang SS, Guillermier C, Wang M, Poczatek JC, Suzuki N, Loscalzo J, Lechene C. Quantitative imaging of selenoprotein with multi-isotope imaging mass spectrometry (MIMS). Surf Interface Anal. 2014 Nov 01; 46(Suppl 1):154-157. PMID: 26379338.
    View in: PubMed
  68. Wang RS, Oldham WM, Loscalzo J. Network-based association of hypoxia-responsive genes with cardiovascular diseases. New J Phys. 2014 Oct 24; 16(10):105014. PMID: 25530704.
    View in: PubMed
  69. Hamnvik OP, Saldana F, Levy BD, Loscalzo J. Clinical problem-solving. Against the grain. N Engl J Med. 2014 Oct 02; 371(14):1333-8. PMID: 25271607.
    View in: PubMed
  70. Bui AH, O'Gara PT, Economy KE, Miller AL, Loscalzo J. Clinical problem-solving. A tight predicament. N Engl J Med. 2014 Sep 04; 371(10):953-9. PMID: 25184868.
    View in: PubMed
  71. Hall KT, Nelson CP, Davis RB, Buring JE, Kirsch I, Mittleman MA, Loscalzo J, Samani NJ, Ridker PM, Kaptchuk TJ, Chasman DI. Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2014 Sep; 34(9):2160-7. PMID: 25035343; PMCID: PMC4148908.
  72. Chu JH, Hersh CP, Castaldi PJ, Cho MH, Raby BA, Laird N, Bowler R, Rennard S, Loscalzo J, Quackenbush J, Silverman EK. Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD. BMC Syst Biol. 2014 Jun 25; 8:78. PMID: 24964944; PMCID: PMC4105829.
  73. Ridker PM, Chasman DI, Rose L, Loscalzo J, Elias JA. Plasma levels of the proinflammatory chitin-binding glycoprotein YKL-40, variation in the chitinase 3-like 1 gene (CHI3L1), and incident cardiovascular events. J Am Heart Assoc. 2014 Jun 23; 3(3):e000897. PMID: 24958781; PMCID: PMC4309091.
  74. Loscalzo J, Handy DE. Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series). Pulm Circ. 2014 Jun; 4(2):169-74. PMID: 25006435; PMCID: PMC4070783.
  75. Hall K, Nelson C, Davis R, Buring J, Kirsch I, Mittleman M, Loscalzo J, Samani N, Ridker P, Kaptchuk T, Chasman D. Catechol-O-methyltransferase Associated Risk of Cardiovascular Disease Is Modified by Treatment with Vitamin E. J Altern Complement Med. 2014 May; 20(5):A3. PMID: 24805564.
    View in: PubMed
  76. Gibson CJ, Britton KA, Miller AL, Loscalzo J. Clinical problem-solving. Out of the blue. N Engl J Med. 2014 May 01; 370(18):1742-8. PMID: 24785210.
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  77. Loscalzo J. Keshan disease, selenium deficiency, and the selenoproteome. N Engl J Med. 2014 May 01; 370(18):1756-60. PMID: 24785212.
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  78. Maron BA, Oldham WM, Chan SY, Vargas SO, Arons E, Zhang YY, Loscalzo J, Leopold JA. Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation. 2014 Jul 08; 130(2):168-79. PMID: 25001622; PMCID: PMC4090713.
  79. Baffy G, Loscalzo J. Complexity and network dynamics in physiological adaptation: an integrated view. Physiol Behav. 2014 May 28; 131:49-56. PMID: 24751342.
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  80. Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, de Almeida IT, Blom HJ, Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, Handy DE. Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem. 2014 May 30; 289(22):15350-62. PMID: 24719327; PMCID: PMC4140892.
  81. Hamnvik OP, Becker CB, Levy BD, Loscalzo J. Clinical problem-solving. Wasting away. N Engl J Med. 2014 Mar 06; 370(10):959-66. PMID: 24597870.
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  82. Loscalzo J. A celebration of failure. Circulation. 2014 Mar 04; 129(9):953-5. PMID: 24589694; PMCID: PMC3974547.
  83. Cottrill KA, Chan SY, Loscalzo J. Hypoxamirs and mitochondrial metabolism. Antioxid Redox Signal. 2014 Sep 10; 21(8):1189-201. PMID: 24111795; PMCID: PMC4142855.
  84. Goodman R, Dellaripa PF, Miller AL, Loscalzo J. Clinical problem-solving. An unusual case of abdominal pain. N Engl J Med. 2014 Jan 02; 370(1):70-5. PMID: 24382068.
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  85. Zhao Y, Yang Y, Loscalzo J. Real-time assessment of the metabolic profile of living cells with genetically encoded NADH sensors. Methods Enzymol. 2014; 542:349-67. PMID: 24862275; PMCID: PMC4189816.
  86. Liao JM, Stewart GC, Padera RF, Miller AL, Loscalzo J. Clinical problem-solving. A curious case of chest pain. N Engl J Med. 2013 Nov 07; 369(19):1844-50. PMID: 24195552.
    View in: PubMed
  87. Handy DE, Loscalzo J, Leopold JA. Systems analysis of oxidant stress in the vasculature. IUBMB Life. 2013 Nov; 65(11):911-20. PMID: 24265198; PMCID: PMC4189813.
  88. Yin T, Bader AR, Hou TK, Maron BA, Kao DD, Qian R, Kohane DS, Handy DE, Loscalzo J, Zhang YY. SDF-1a in glycan nanoparticles exhibits full activity and reduces pulmonary hypertension in rats. Biomacromolecules. 2013 Nov 11; 14(11):4009-20. PMID: 24059347; PMCID: PMC3833441.
  89. Fox MC, Lakdawala N, Miller AL, Loscalzo J. Clinical problem-solving. A patient with syncope. N Engl J Med. 2013 Sep 05; 369(10):966-72. PMID: 24004124.
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  90. Joseph J, Loscalzo J. Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology. Nutrients. 2013 Aug 15; 5(8):3235-56. PMID: 23955381; PMCID: PMC3775251.
  91. Loscalzo J. The identification of nitric oxide as endothelium-derived relaxing factor. Circ Res. 2013 Jul 05; 113(2):100-3. PMID: 23833290; PMCID: PMC3711180.
  92. Casey JD, Solomon DH, Gaziano TA, Miller AL, Loscalzo J. Clinical problem-solving. A patient with migrating polyarthralgias. N Engl J Med. 2013 Jul 04; 369(1):75-80. PMID: 23822780.
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  93. Kao DD, Oldebeken SR, Rai A, Lubos E, Leopold JA, Loscalzo J, Handy DE. Tumor necrosis factor-a-mediated suppression of dual-specificity phosphatase 4: crosstalk between NF?B and MAPK regulates endothelial cell survival. Mol Cell Biochem. 2013 Oct; 382(1-2):153-62. PMID: 23812841; PMCID: PMC3772965.
  94. Maron BA, Waxman AB, Opotowsky AR, Gillies H, Blair C, Aghamohammadzadeh R, Loscalzo J, Leopold JA. Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials). Am J Cardiol. 2013 Sep 01; 112(5):720-5. PMID: 23751938; PMCID: PMC3906683.
  95. Scully EP, Klompas M, Morgan EA, Miller AL, Loscalzo J. Clinical problem-solving. Waiting for the other foot to drop. N Engl J Med. 2013 Jun 06; 368(23):2220-5. PMID: 23738548.
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  96. Nallamshetty S, Chan SY, Loscalzo J. Hypoxia: a master regulator of microRNA biogenesis and activity. Free Radic Biol Med. 2013 Sep; 64:20-30. PMID: 23712003; PMCID: PMC3762925.
  97. Rao DA, Lakdawala NK, Miller AL, Loscalzo J. Clinical problem-solving. In the thick of it. N Engl J Med. 2013 May 02; 368(18):1732-8. PMID: 23635054.
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  98. Loscalzo J. Gut microbiota, the genome, and diet in atherogenesis. N Engl J Med. 2013 Apr 25; 368(17):1647-9. PMID: 23614591.
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  99. Fox CS, Loscalzo J. Editor's note. Circulation. 2013 Apr 02; 127(13):1353. PMID: 23662311.
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  100. Loscalzo J. Ever at the mercy of well-intentioned regulations: their adverse consequences and unproven benefits. Circulation. 2013 Mar 19; 127(11):1169-72. PMID: 23509030.
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  101. Loscalzo J. Venous thrombosis in the nephrotic syndrome. N Engl J Med. 2013 Mar 07; 368(10):956-8. PMID: 23465106.
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  102. Perencevich M, Saltzman JR, Levy BD, Loscalzo J. Clinical problem-solving. The search is on. N Engl J Med. 2013 Feb 07; 368(6):562-7. PMID: 23388008.
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  103. Loscalzo J. From clinical observation to mechanism--Heyde's syndrome. N Engl J Med. 2013 Feb 07; 368(6):579-80. PMID: 23388020.
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  104. Joseph J, Loscalzo J. Selenistasis: epistatic effects of selenium on cardiovascular phenotype. Nutrients. 2013 Jan 31; 5(2):340-58. PMID: 23434902; PMCID: PMC3635198.
  105. Maron BA, Loscalzo J. Pulmonary hypertension: pathophysiology and signaling pathways. Handb Exp Pharmacol. 2013; 218:31-58. PMID: 24092335.
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  106. Balderman JA, Lee HY, Mahoney CE, Handy DE, White K, Annis S, Lebeche D, Hajjar RJ, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification. J Am Heart Assoc. 2012 Dec; 1(6):e003905. PMID: 23316327; PMCID: PMC3540659.
  107. Ballantyne CM, Pitt B, Loscalzo J, Cain VA, Raichlen JS. Alteration of relation of atherogenic lipoprotein cholesterol to apolipoprotein B by intensive statin therapy in patients with acute coronary syndrome (from the Limiting UNdertreatment of lipids in ACS With Rosuvastatin [LUNAR] Trial). Am J Cardiol. 2013 Feb 15; 111(4):506-9. PMID: 23237107.
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  108. Zhang Z, Yang Z, Zhu B, Hu J, Liew CW, Zhang Y, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose. PLoS One. 2012; 7(11):e49128. PMID: 23185302; PMCID: PMC3501497.
  109. Loscalzo J. From clinical observation to mechanism--Heyde's syndrome. N Engl J Med. 2012 Nov 15; 367(20):1954-6. PMID: 23150964.
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  110. King LY, Tucker JK, Lee LS, Levy BD, Loscalzo J. Clinical problem-solving. A complex cause of pleuritic chest pain. N Engl J Med. 2012 11 01; 367(18):1742-8. PMID: 23113486.
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  111. Maron BA, Opotowsky AR, Landzberg MJ, Loscalzo J, Waxman AB, Leopold JA. Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study. Eur J Heart Fail. 2013 Mar; 15(3):277-83. PMID: 23111998; PMCID: PMC3576899.
  112. Metes-Kosik N, Luptak I, Dibello PM, Handy DE, Tang SS, Zhi H, Qin F, Jacobsen DW, Loscalzo J, Joseph J. Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. Mol Nutr Food Res. 2012 Dec; 56(12):1812-24. PMID: 23097236; PMCID: PMC3546539.
  113. Kajstura J, Rota M, Cappetta D, Ogórek B, Arranto C, Bai Y, Ferreira-Martins J, Signore S, Sanada F, Matsuda A, Kostyla J, Caballero MV, Fiorini C, D'Alessandro DA, Michler RE, del Monte F, Hosoda T, Perrella MA, Leri A, Buchholz BA, Loscalzo J, Anversa P. Cardiomyogenesis in the aging and failing human heart. Circulation. 2012 Oct 09; 126(15):1869-81. PMID: 22955965; PMCID: PMC3477474.
  114. Maron BA, Tang SS, Loscalzo J. S-nitrosothiols and the S-nitrosoproteome of the cardiovascular system. Antioxid Redox Signal. 2013 Jan 20; 18(3):270-87. PMID: 22770551; PMCID: PMC3518544.
  115. Rhee DK, Clark RP, Blair RJ, Katz JT, Loscalzo J. Clinical problem-solving. Breathtaking journey. N Engl J Med. 2012 Aug 02; 367(5):452-7. PMID: 22853017.
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  116. Silverman EK, Loscalzo J. Network medicine approaches to the genetics of complex diseases. Discov Med. 2012 Aug; 14(75):143-52. PMID: 22935211; PMCID: PMC3545396.
  117. Kajstura J, Bai Y, Cappetta D, Kim J, Arranto C, Sanada F, D'Amario D, Matsuda A, Bardelli S, Ferreira-Martins J, Hosoda T, Leri A, Rota M, Loscalzo J, Anversa P. Tracking chromatid segregation to identify human cardiac stem cells that regenerate extensively the infarcted myocardium. Circ Res. 2012 Sep 14; 111(7):894-906. PMID: 22851539; PMCID: PMC3482833.
  118. Chan SY, Loscalzo J. The emerging paradigm of network medicine in the study of human disease. Circ Res. 2012 Jul 20; 111(3):359-74. PMID: 22821909; PMCID: PMC3425394.
  119. Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation. 2012 Aug 21; 126(8):963-74. PMID: 22787113; PMCID: PMC3534848.
  120. Merola JF, Ghoroghchian PP, Samuels MA, Levy BD, Loscalzo J. Clinical problem-solving. At a loss. N Engl J Med. 2012 Jul 05; 367(1):67-72. PMID: 22762321.
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  121. White K, Loscalzo J, Chan SY. Holding our breath: The emerging and anticipated roles of microRNA in pulmonary hypertension. Pulm Circ. 2012 Jul; 2(3):278-90. PMID: 23130098; PMCID: PMC3487298.
  122. Ueland PM, Loscalzo J. Homocysteine and cardiovascular risk: the perils of reductionism in a complex system. Clin Chem. 2012 Dec; 58(12):1623-5. PMID: 22623744.
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  123. Antman E, Weiss S, Loscalzo J. Systems pharmacology, pharmacogenetics, and clinical trial design in network medicine. Wiley Interdiscip Rev Syst Biol Med. 2012 Jul-Aug; 4(4):367-83. PMID: 22581565; PMCID: PMC3783940.
  124. Solomon DA, Fanta CH, Levy BD, Loscalzo J. Clinical problem-solving. Whistling in the dark. N Engl J Med. 2012 May 03; 366(18):1725-30. PMID: 22551132.
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  125. Chan SY, White K, Loscalzo J. Deciphering the molecular basis of human cardiovascular disease through network biology. Curr Opin Cardiol. 2012 May; 27(3):202-9. PMID: 22382498; PMCID: PMC3521498.
  126. Anversa P, Perrella MA, Kourembanas S, Choi AM, Loscalzo J. Regenerative pulmonary medicine: potential and promise, pitfalls and challenges. Eur J Clin Invest. 2012 Aug; 42(8):900-13. PMID: 22435680; PMCID: PMC3513384.
  127. Loscalzo J. Irreproducible experimental results: causes, (mis)interpretations, and consequences. Circulation. 2012 Mar 13; 125(10):1211-4. PMID: 22412087; PMCID: PMC3319669.
  128. Rinne ML, McGinnis SM, Samuels MA, Katz JT, Loscalzo J. Clinical problem-solving. A startling decline. N Engl J Med. 2012 Mar 01; 366(9):836-42. PMID: 22375976.
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  129. Parikh VN, Jin RC, Rabello S, Gulbahce N, White K, Hale A, Cottrill KA, Shaik RS, Waxman AB, Zhang YY, Maron BA, Hartner JC, Fujiwara Y, Orkin SH, Haley KJ, Barabási AL, Loscalzo J, Chan SY. MicroRNA-21 integrates pathogenic signaling to control pulmonary hypertension: results of a network bioinformatics approach. Circulation. 2012 Mar 27; 125(12):1520-32. PMID: 22371328; PMCID: PMC3353408.
  130. Pitt B, Loscalzo J, Monyak J, Miller E, Raichlen J. Comparison of lipid-modifying efficacy of rosuvastatin versus atorvastatin in patients with acute coronary syndrome (from the LUNAR study). Am J Cardiol. 2012 May 01; 109(9):1239-46. PMID: 22360820.
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  131. Handy DE, Loscalzo J. Redox regulation of mitochondrial function. Antioxid Redox Signal. 2012 Jun 01; 16(11):1323-67. PMID: 22146081; PMCID: PMC3324814.
  132. Berzin TM, Greenberger NJ, Levy BD, Loscalzo J. Clinical problem-solving. Worth a second look. N Engl J Med. 2012 Feb 02; 366(5):463-8. PMID: 22296081.
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  133. Loscalzo J. Personalized cardiovascular medicine and drug development: time for a new paradigm. Circulation. 2012 Jan 31; 125(4):638-45. PMID: 22294708; PMCID: PMC3273851.
  134. Gavin MC, Morse D, Partridge AH, Levy BD, Loscalzo J. Clinical problem-solving. Breathless. N Engl J Med. 2012 Jan 05; 366(1):75-81. PMID: 22216845.
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  135. Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J. Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol. 2012 Mar; 52(3):753-60. PMID: 22227328; PMCID: PMC3294144.
  136. Pointer MA, Daumerie G, Bridges L, Yancey S, Howard K, Davis W, Huang P, Loscalzo J. Physiological stress increases renal injury in eNOS-knockout mice. Hypertens Res. 2012 Mar; 35(3):318-24. PMID: 22170389; PMCID: PMC4405173.
  137. Malinouski M, Kehr S, Finney L, Vogt S, Carlson BA, Seravalli J, Jin R, Handy DE, Park TJ, Loscalzo J, Hatfield DL, Gladyshev VN. High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. Antioxid Redox Signal. 2012 Feb 01; 16(3):185-92. PMID: 21854231; PMCID: PMC3234661.
  138. Lee AI, Koo S, Vaidya A, Katz JT, Loscalzo J. Clinical problem-solving. A bird's-eye view of fever. N Engl J Med. 2011 Nov 03; 365(18):1727-32. PMID: 22047564.
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  139. Zhao Y, Jin J, Hu Q, Zhou HM, Yi J, Yu Z, Xu L, Wang X, Yang Y, Loscalzo J. Genetically encoded fluorescent sensors for intracellular NADH detection. Cell Metab. 2011 Oct 05; 14(4):555-66. PMID: 21982715; PMCID: PMC3253140.
  140. Anversa P, Kajstura J, Leri A, Loscalzo J. Tissue-specific adult stem cells in the human lung. Nat Med. 2011 Sep 07; 17(9):1038-9. PMID: 21900912.
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  141. Horwitz RI, Kassirer JP, Holmboe ES, Humphrey HJ, Verghese A, Croft C, Kwok M, Loscalzo J. Internal medicine residency redesign: proposal of the Internal Medicine Working Group. Am J Med. 2011 Sep; 124(9):806-12. PMID: 21854887.
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  142. Liberman M, Johnson RC, Handy DE, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification. Biochem Biophys Res Commun. 2011 Sep 30; 413(3):436-41. PMID: 21907184; PMCID: PMC3197703.
  143. Lubos E, Kelly NJ, Oldebeken SR, Leopold JA, Zhang YY, Loscalzo J, Handy DE. Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation. J Biol Chem. 2011 Oct 14; 286(41):35407-17. PMID: 21852236; PMCID: PMC3195617.
  144. Loscalzo J. Lipid metabolism by gut microbes and atherosclerosis. Circ Res. 2011 Jul 08; 109(2):127-9. PMID: 21737814.
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  145. Morris A, Grudberg S, Levy BD, Loscalzo J. Clinical problem-solving. A sleeping giant. N Engl J Med. 2011 Jul 07; 365(1):72-7. PMID: 21732839.
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  146. Zhang J, Handy DE, Wang Y, Bouchard G, Selhub J, Loscalzo J, Carey MC. Hyperhomocysteinemia from trimethylation of hepatic phosphatidylethanolamine during cholesterol cholelithogenesis in inbred mice. Hepatology. 2011 Aug; 54(2):697-706. PMID: 21567442; PMCID: PMC3145001.
  147. Handy DE, Castro R, Loscalzo J. Epigenetic modifications: basic mechanisms and role in cardiovascular disease. Circulation. 2011 May 17; 123(19):2145-56. PMID: 21576679; PMCID: PMC3107542.
  148. Kajstura J, Rota M, Hall SR, Hosoda T, D'Amario D, Sanada F, Zheng H, Ogórek B, Rondon-Clavo C, Ferreira-Martins J, Matsuda A, Arranto C, Goichberg P, Giordano G, Haley KJ, Bardelli S, Rayatzadeh H, Liu X, Quaini F, Liao R, Leri A, Perrella MA, Loscalzo J, Anversa P. Evidence for human lung stem cells. N Engl J Med. 2011 May 12; 364(19):1795-806. PMID: 21561345; PMCID: PMC3197695.
  149. Rogal SS, Ukomadu C, Levy BD, Loscalzo J. Clinical problem-solving. A sweet source of abdominal pain. N Engl J Med. 2011 May 05; 364(18):1762-7. PMID: 21542747.
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  150. Loscalzo J. Systems biology and personalized medicine: a network approach to human disease. Proc Am Thorac Soc. 2011 May; 8(2):196-8. PMID: 21543801.
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  151. Jin RC, Mahoney CE, Coleman Anderson L, Ottaviano F, Croce K, Leopold JA, Zhang YY, Tang SS, Handy DE, Loscalzo J. Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. Circulation. 2011 May 10; 123(18):1963-73. PMID: 21518981; PMCID: PMC3107543.
  152. Labunskyy VM, Lee BC, Handy DE, Loscalzo J, Hatfield DL, Gladyshev VN. Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal. 2011 Jun 15; 14(12):2327-36. PMID: 21194350; PMCID: PMC3096499.
  153. Loscalzo J. Can scientific quality be quantified? Circulation. 2011 Mar 08; 123(9):947-50. PMID: 21382902.
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  154. Vaidya A, Kaiser UB, Levy BD, Loscalzo J. Clinical problem-solving. Lying low. N Engl J Med. 2011 Mar 03; 364(9):871-5. PMID: 21366479.
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  155. Szent-Gyorgyi LE, Coblyn J, Turchin A, Loscalzo J, Kachalia A. Building a departmental quality program: a patient-based and provider-led approach. Acad Med. 2011 Mar; 86(3):314-20. PMID: 21248609.
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  156. Loscalzo J, Barabasi AL. Systems biology and the future of medicine. Wiley Interdiscip Rev Syst Biol Med. 2011 Nov-Dec; 3(6):619-27. PMID: 21928407; PMCID: PMC3188693.
  157. Fisher M, Loscalzo J. The perils of combination antithrombotic therapy and potential resolutions. Stroke. 2011 Feb; 42(2):278-81. PMID: 21263146.
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  158. Fisher M, Loscalzo J. The perils of combination antithrombotic therapy and potential resolutions. Circulation. 2011 Jan 25; 123(3):232-5. PMID: 21263004.
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  159. Miller AL, Schissel S, Levy BD, Loscalzo J. Clinical problem-solving. A crazy cause of dyspnea. N Engl J Med. 2011 Jan 06; 364(1):72-7. PMID: 21208111.
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  160. Barabási AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011 Jan; 12(1):56-68. PMID: 21164525; PMCID: PMC3140052.
  161. Chan SY, Loscalzo J. Pulmonary vascular disease related to hemodynamic stress in the pulmonary circulation. Compr Physiol. 2011 Jan; 1(1):123-39. PMID: 23737167; PMCID: PMC3730284.
  162. Grad YH, Seifter JL, Levy BD, Loscalzo J. Clinical problem-solving. Bitter pills. N Engl J Med. 2010 Nov 04; 363(19):1847-51. PMID: 21047229; PMCID: PMC4098700.
  163. Loscalzo J. The cellular response to hypoxia: tuning the system with microRNAs. J Clin Invest. 2010 Nov; 120(11):3815-7. PMID: 20972325; PMCID: PMC2965005.
  164. Miller AL, Falk RH, Levy BD, Loscalzo J. Clinical problem-solving. A heavy heart. N Engl J Med. 2010 Oct 07; 363(15):1464-9. PMID: 20925549.
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  165. Michas G, Liberman M, Becker KC, Handy DE, Loscalzo J, Leopold JA. Reciprocal regulation of 11ß-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro. Mol Cell Biochem. 2011 Jan; 346(1-2):69-79. PMID: 20922465; PMCID: PMC2996480.
  166. Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM. Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1554-62. PMID: 20833821; PMCID: PMC3029941.
  167. Levison JH, Barbieri RL, Katz JT, Loscalzo J. Clinical problem-solving. Hard to conceive. N Engl J Med. 2010 Sep 02; 363(10):965-70. PMID: 20818907; PMCID: PMC3684238.
  168. Jin RC, Loscalzo J. Vascular Nitric Oxide: Formation and Function. J Blood Med. 2010 Aug 01; 2010(1):147-162. PMID: 21572574.
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  169. Lauten EH, VerBerkmoes J, Choi J, Jin R, Edwards DA, Loscalzo J, Zhang YY. Nanoglycan complex formulation extends VEGF retention time in the lung. Biomacromolecules. 2010 Jul 12; 11(7):1863-72. PMID: 20575564; PMCID: PMC2929700.
  170. Liu AY, Lowe RC, Levy BD, Katz JT, Loscalzo J. Clinical problem-solving. A rash hypothesis. N Engl J Med. 2010 Jul 01; 363(1):72-8. PMID: 20592300.
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  171. Antman E, Pfeffer M, Stevenson W, Loscalzo J. New section in Circulation: implications of contemporary clinical trials. Circulation. 2010 Jun 08; 121(22):2446. PMID: 20530021.
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  172. Hu W, Jin R, Zhang J, You T, Peng Z, Ge X, Bronson RT, Halperin JA, Loscalzo J, Qin X. The critical roles of platelet activation and reduced NO bioavailability in fatal pulmonary arterial hypertension in a murine hemolysis model. Blood. 2010 Sep 02; 116(9):1613-22. PMID: 20511540; PMCID: PMC2938847.
  173. Zeller T, Wild P, Szymczak S, Rotival M, Schillert A, Castagne R, Maouche S, Germain M, Lackner K, Rossmann H, Eleftheriadis M, Sinning CR, Schnabel RB, Lubos E, Mennerich D, Rust W, Perret C, Proust C, Nicaud V, Loscalzo J, Hübner N, Tregouet D, Münzel T, Ziegler A, Tiret L, Blankenberg S, Cambien F. Genetics and beyond--the transcriptome of human monocytes and disease susceptibility. PLoS One. 2010 May 18; 5(5):e10693. PMID: 20502693; PMCID: PMC2872668.
  174. Britton KA, Stevenson WG, Levy BD, Katz JT, Loscalzo J. Clinical problem-solving. The beat goes on. N Engl J Med. 2010 May 06; 362(18):1721-6. PMID: 20445184.
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  175. McMahon GT, Katz JT, Thorndike ME, Levy BD, Loscalzo J. Evaluation of a redesign initiative in an internal-medicine residency. N Engl J Med. 2010 Apr 08; 362(14):1304-11. PMID: 20375407.
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  176. Chan SY, Loscalzo J. MicroRNA-210: a unique and pleiotropic hypoxamir. Cell Cycle. 2010 Mar 15; 9(6):1072-83. PMID: 20237418; PMCID: PMC2912143.
  177. Lubos E, Mahoney CE, Leopold JA, Zhang YY, Loscalzo J, Handy DE. Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression. FASEB J. 2010 Jul; 24(7):2525-32. PMID: 20219985; PMCID: PMC2887263.
  178. Chamarthi B, Morris CA, Kaiser UB, Katz JT, Loscalzo J. Clinical problem-solving. Stalking the diagnosis. N Engl J Med. 2010 Mar 04; 362(9):834-9. PMID: 20200388.
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  179. Johnson JA, Everett BM, Katz JT, Loscalzo J. Clinical problem-solving. Painful purple toes. N Engl J Med. 2010 Jan 07; 362(1):67-73. PMID: 20054049.
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  180. Loscalzo J. Antioxidant enzyme deficiencies and vascular disease. Expert Rev Endocrinol Metab. 2010 Jan 01; 5(1):15-18. PMID: 20190873.
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  181. Zhang Z, Liew CW, Handy DE, Zhang Y, Leopold JA, Hu J, Guo L, Kulkarni RN, Loscalzo J, Stanton RC. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J. 2010 May; 24(5):1497-505. PMID: 20032314; PMCID: PMC2879949.
  182. Daumerie G, Bridges L, Yancey S, Davis W, Huang P, Loscalzo J, Pointer MA. The effect of salt on renal damage in eNOS-deficient mice. Hypertens Res. 2010 Feb; 33(2):170-6. PMID: 19960018; PMCID: PMC4419703.
  183. Cuker A, Connors JM, Katz JT, Levy BD, Loscalzo J. Clinical problem-solving. A bloody mystery. N Engl J Med. 2009 Nov 05; 361(19):1887-94. PMID: 19890132.
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  184. Loscalzo J. Homocysteine-mediated thrombosis and angiostasis in vascular pathobiology. J Clin Invest. 2009 Nov; 119(11):3203-5. PMID: 19841539; PMCID: PMC2769170.
  185. Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J. 2010 Feb; 24(2):609-16. PMID: 19805580; PMCID: PMC2812032.
  186. Lim CC, Bryan NS, Jain M, Garcia-Saura MF, Fernandez BO, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R. Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol Heart Circ Physiol. 2009 Dec; 297(6):H2144-53. PMID: 19801492; PMCID: PMC2793140.
  187. Chan SY, Zhang YY, Hemann C, Mahoney CE, Zweier JL, Loscalzo J. MicroRNA-210 controls mitochondrial metabolism during hypoxia by repressing the iron-sulfur cluster assembly proteins ISCU1/2. Cell Metab. 2009 Oct; 10(4):273-84. PMID: 19808020; PMCID: PMC2759401.
  188. Wolpin BM, Weller PF, Katz JT, Levy BD, Loscalzo J. Clinical problem-solving. The writing on the wall. N Engl J Med. 2009 Oct 01; 361(14):1387-92. PMID: 19797286.
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  189. Leopold JA, Loscalzo J. Oxidative risk for atherothrombotic cardiovascular disease. Free Radic Biol Med. 2009 Dec 15; 47(12):1673-706. PMID: 19751821; PMCID: PMC2797369.
  190. Lubos E, Sinning CR, Schnabel RB, Wild PS, Zeller T, Rupprecht HJ, Bickel C, Lackner KJ, Peetz D, Loscalzo J, Münzel T, Blankenberg S. Serum selenium and prognosis in cardiovascular disease: results from the AtheroGene study. Atherosclerosis. 2010 Mar; 209(1):271-7. PMID: 19836749; PMCID: PMC2921799.
  191. Jahangir E, Vita JA, Handy D, Holbrook M, Palmisano J, Beal R, Loscalzo J, Eberhardt RT. The effect of L-arginine and creatine on vascular function and homocysteine metabolism. Vasc Med. 2009 Aug; 14(3):239-48. PMID: 19651674; PMCID: PMC2840406.
  192. Bitton A, Yialamas M, Levy BD, Katz JT, Loscalzo J. Clinical problem-solving. A fragile balance. N Engl J Med. 2009 Jul 02; 361(1):74-9. PMID: 19571286.
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  193. Joseph J, Handy DE, Loscalzo J. Quo vadis: whither homocysteine research? Cardiovasc Toxicol. 2009 Jun; 9(2):53-63. PMID: 19484390; PMCID: PMC3266720.
  194. Loscalzo J. Pilot trials in clinical research: of what value are they? Circulation. 2009 Apr 07; 119(13):1694-6. PMID: 19349331.
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  195. Qin X, Hu W, Song W, Blair P, Wu G, Hu X, Song Y, Bauer S, Feelisch M, Leopold JA, Loscalzo J, Halperin JA. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009 Apr; 84(4):221-7. PMID: 19229985; PMCID: PMC4280257.
  196. Handy DE, Lubos E, Yang Y, Galbraith JD, Kelly N, Zhang YY, Leopold JA, Loscalzo J. Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses. J Biol Chem. 2009 May 01; 284(18):11913-21. PMID: 19254950; PMCID: PMC2673260.
  197. Ottaviano FG, Tang SS, Handy DE, Loscalzo J. Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells. Mol Cell Biochem. 2009 Jul; 327(1-2):111-26. PMID: 19219623; PMCID: PMC2693281.
  198. Maron BA, Zhang YY, Handy DE, Beuve A, Tang SS, Loscalzo J, Leopold JA. Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. J Biol Chem. 2009 Mar 20; 284(12):7665-72. PMID: 19141618; PMCID: PMC2658060.
  199. Freedman JE, Blair P, Loscalzo J. Chapter 2. Overview of the platelet-dependent thrombosis. In: New Therapeutic Agents in Thrombosis and Thrombolysis, 3rd Edition. Freedman JE, Loscalzo J, editors. 2009; 9-18.
  200. Malhotra A, Loscalzo J. Sleep and cardiovascular disease: an overview. Prog Cardiovasc Dis. 2009 Jan-Feb; 51(4):279-84. PMID: 19110129; PMCID: PMC2722952.
  201. Loscalzo J. Antithrombotic therapy in chronic atrial fibrillation. (Update to Chapter 226). Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine, 17th Edition. 2009.
  202. Loscalzo J. Percutaneous coronary intervention compared with coronary artery bypass grafting in severe coronary artery disease. (Update to Chapter 240). Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine, 17th Edition. 2009.
  203. Loscalzo J. Cardiovascular prevention guidelines in practice. (Update to Chaper 218). Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine, 17th Edition. 2009.
  204. Maron BA, Loscalzo J. The treatment of hyperhomocysteinemia. Annu Rev Med. 2009; 60:39-54. PMID: 18729731; PMCID: PMC2716415.
  205. Loscalzo j. Consequences of donating a kidney. (Update to Chapter 276). Fauci AS, Braunwald DL, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine, 17th Edition. 2009.
  206. Loscalzo J. Polypill use for cardiovascular risk factor reduction. (Update to Chapter 218). Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine, 17th Edition. 2009.
  207. Raiesdana A, Loscalzo J. Chapter 27. Pulmonary arterial hypertension. In: Pharmacology and Therapeutics: Principles to Practice. Waldman SA, Terzic A, editors. 2009; 405-15.
  208. Lim CC, Bryan NS, Jain M, Cui L, Sawyer DB, Handy DE, Loscalzo J, Feelisch M, Liao R. Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. Am J Physiol. 2009; 297(6):H2144-53.
  209. Freedman JE, Loscalzo J. Chapter 38. Epilogue: the evolution of therapeutic management of thrombotic and cardiovascular disease. In: New Therapeutic Agents in Thrombosis and Thrombolysis, 3rd Edition. Freedman JE, Loscalzo J, editors. 2009; 667-70.
  210. McMahon T, Solomon CG, Ross JJ, Loscalzo J, Champion EW. Interactive medical cases - a new Journal feature. N Engl J Med. 2009; 361:1112-3.
  211. Schnabel R, Lubos E, Messow CM, Sinning CR, Zeller T, Wild PS, Peetz D, Handy DE, Munzel T, Loscalzo J, Lackner KJ, Blankenberg S. Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study. Am Heart J. 2008 Dec; 156(6):1201.e1-11. PMID: 19033020; PMCID: PMC3624729.
  212. Loscalzo J. Paraoxonase and coronary heart disease risk: language misleads, linkage misinforms, function clarifies. Circ Cardiovasc Genet. 2008 Dec; 1(2):79-80. PMID: 20031548.
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  213. Loscalzo J. Membrane redox state and apoptosis: death by peroxide. Cell Metab. 2008 Sep; 8(3):182-3. PMID: 18762018.
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  214. Blicharz TM, Rissin DM, Bowden M, Hayman RB, DiCesare C, Bhatia JS, Grand-Pierre N, Siqueira WL, Helmerhorst EJ, Loscalzo J, Oppenheim FG, Walt DR. Use of colorimetric test strips for monitoring the effect of hemodialysis on salivary nitrite and uric acid in patients with end-stage renal disease: a proof of principle. Clin Chem. 2008 Sep; 54(9):1473-80. PMID: 18676588; PMCID: PMC2710817.
  215. Sung AD, Cheng S, Moslehi J, Scully EP, Prior JM, Loscalzo J. Hepatocellular carcinoma with intracavitary cardiac involvement: a case report and review of the literature. Am J Cardiol. 2008 Sep 01; 102(5):643-5. PMID: 18721529.
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  216. Song Y, Coleman L, Shi J, Beppu H, Sato K, Walsh K, Loscalzo J, Zhang YY. Inflammation, endothelial injury, and persistent pulmonary hypertension in heterozygous BMPR2-mutant mice. Am J Physiol Heart Circ Physiol. 2008 Aug; 295(2):H677-90. PMID: 18552156; PMCID: PMC2519229.
  217. A Statement on Ethics From the HEART Group. Circ Res. 2008 May 09; 102(9):e104-5. PMID: 18467635.
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  218. Ector H, Lancellotti P, Roberts WC, Wenger NK, Moss AJ, Smith ER, Borer JS, Eagle KA, Freedman J, Krum H, Lang C, Remme WJ, Piper HM, White CJ, Loscalzo J, Marbán E, Sobel BE, Roberts R, Rahimtoola SH, Camm AJ, Van de Werf F, Swedberg K, Timmis AD, Stone KS, Zipes DP, Iosselani DG, Taylor AJ, Rosen MR, Grines CL, DeMaria AN, Narula J, King SB, Wagner GS, Saksena S, Pearlman AS, Bodnar E, Emery RW, Cohn LH, van der Wall EE, Abdulla RI, Lesch M, Alfonso F, Ekroth R. A statement on ethics from the HEART Group. JACC Cardiovasc Imaging. 2008 May; 1(3):410-2. PMID: 19356460.
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  219. Lubos E, Handy DE, Loscalzo J. Role of oxidative stress and nitric oxide in atherothrombosis. Front Biosci. 2008 May 01; 13:5323-44. PMID: 18508590; PMCID: PMC2617738.
  220. Pitt B, Loscalzo J, Ycas J, Raichlen JS. Lipid levels after acute coronary syndromes. J Am Coll Cardiol. 2008 Apr 15; 51(15):1440-5. PMID: 18402897.
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  221. Leopold JA, Loscalzo J. Oxidative mechanisms and atherothrombotic cardiovascular disease. Drug Discov Today Ther Strateg. 2008 Mar; 5(1):5-13. PMID: 21048889.
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  222. Loscalzo J, Tomaselli GF, Vaughan DE, Walsh RA. Task force 7: training in cardiovascular research. J Am Coll Cardiol. 2008 Jan 22; 51(3):380-3. PMID: 18206756.
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  223. Loscalzo J, Braunwald E, Libby P. Chapter 217. Basic biology of the cardiovascular system. In: Harrison's Principles of Internal Medicine, 17th Edition. Fauci A, Braunwald E, Kasper DL, Longo DL, Hauser SL, Jameson JL, Loscalzo J, editors. 2008; 1365-75.
  224. Braunwald E, Loscalzo J. Chapter 36. Edema. In: Harrison's Principles of Internal Medicine, 17th Edition. Fauci A, Braunwald E, Kasper DL, Longo DL, Hauser SL, Jameson JL, Loscalzo J, editors. 2008; 231-6.
  225. Loscalzo J. Rivaroxaban for prevention of venous thromboembolism. (Update to Chapter 256). Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine, 17th Edition. 2008.
  226. Leopold JA, Loscalzo J. Oxidative mechanisms and atherothrombotic cardiovascular disease. Drug Disc Today: Therap Strat. 2008; 5(1):5-13.
  227. Creager MA, Loscalzo J. Chapte 242. Diseases of the aorta. In: Harrison's Principles of Internal Medicine, 17th Edition. Fauci A, Braunwald E, Kasper DL, Longo DL, Hauser SL, Jameson JL, Loscalzo J, editors. 2008; 1563-8.
  228. Creager MA, Loscalzo J. Chapter 243. Vascular diseases of the extremities. In: Harrison's Principles of Internal Medicine, 17th Edition. Fauci A, Braunwald E, Kasper DL, Longo DL, Hauser SL, Jameson JL, Loscalzo J, editors. 2008; 1568-75.
  229. Loscalzo J. Buflomedil in peripheral arterial obstructive disease (Update to Chapter 243). Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine, 17th Edition. 2008.
  230. Loscalzo J. Paraoxonase and coronary heart disease: language misleads, linkage misinforms, function clarifies. Circ Cardiovascul Gen. 2008; 1:79-80.
  231. Loscalzo J. A bold, new initiative for Circulation. A family of subspecialty journals. Circulation. 2008; 117:4-5.
  232. Ottaviano FG, Handy DE, Loscalzo J. Redox regulation in the extracellular environment. Circ J. 2008 Jan; 72(1):1-16. PMID: 18159092.
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  233. Loscalzo J. Chapter 37. Palpitations. In: Harrison's Principles of Internal Medicine, 17th Edition. Fauci A, Braunwald E, Kasper DL, Longo DL, Hauser SL, Jameson JL, Loscalzo J, editors. 2008; 236-7.
  234. Loscalzo J. Lack of effect of chronic anticholinergic therapy on the progression of chronic obstructive lung disease (Update to Chapter 254). Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine, 17th Edition. 2008.
  235. Loscalzo J. Benefit of catheter ablation in atrial fibrillation. (Update to Chapter 226). Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison's Principles of Internal Medicine, 17th Edition. 2008.
  236. Antman E, Selwyn AP, Braunwald E, Loscalzo J. Chapter 237. Ischemic heart disease. In: Harrison's Principles of Internal Medicine, 17th Edition. Fauci A, Braunwald E, Kasper DL, Longo DL, Hauser SL, Jameson JL, Loscalzo J, editors. 2008; 1514-27.
  237. Voetsch B, Jin RC, Bierl C, Deus-Silva L, Camargo EC, Annichino-Bizacchi JM, Handy DE, Loscalzo J. Role of promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene as a risk factor for cerebral venous thrombosis. Stroke. 2008 Feb; 39(2):303-7. PMID: 18096833.
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  238. Maron BA, Loscalzo J. Should hyperhomocysteinemia be treated in patients with atherosclerotic disease? Curr Atheroscler Rep. 2007 Nov; 9(5):375-83. PMID: 18001620.
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  239. Lubos E, Loscalzo J, Handy DE. Homocysteine and glutathione peroxidase-1. Antioxid Redox Signal. 2007 Nov; 9(11):1923-40. PMID: 17822368.
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  240. Loscalzo J. Association studies in an era of too much information: clinical analysis of new biomarker and genetic data. Circulation. 2007 Oct 23; 116(17):1866-70. PMID: 17965399.
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  241. Letts G, Loscalzo J. Frontiers in nephrology: targeting inflammation using novel nitric oxide donors. J Am Soc Nephrol. 2007 Nov; 18(11):2863-9. PMID: 17942956.
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  242. Sebastian JK, Voetsch B, Stone JH, Romay-Penabad Z, Lo GH, Allen NB, Davis JC, Hoffman GS, McCune WJ, St Clair EW, Specks U, Spiera R, Loscalzo J, Pierangeli S, Merkel PA. The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event. J Rheumatol. 2007 Dec; 34(12):2446-50. PMID: 17918782.
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  243. Chan SY, Loscalzo J. Pathogenic mechanisms of pulmonary arterial hypertension. J Mol Cell Cardiol. 2008 Jan; 44(1):14-30. PMID: 17950310; PMCID: PMC2234575.
  244. Rajasekaran NS, Connell P, Christians ES, Yan LJ, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, Benjamin IJ. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 2007 Aug 10; 130(3):427-39. PMID: 17693254; PMCID: PMC2962423.
  245. Loscalzo J, Kohane I, Barabasi AL. Human disease classification in the postgenomic era: a complex systems approach to human pathobiology. Mol Syst Biol. 2007; 3:124. PMID: 17625512; PMCID: PMC1948102.
  246. Yang Y, Song Y, Loscalzo J. Regulation of the protein disulfide proteome by mitochondria in mammalian cells. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10813-7. PMID: 17581874; PMCID: PMC1904139.
  247. Biolo A, Chao T, Duhaney TA, Kotlyar E, Allensworth-Davies D, Loscalzo J, Sam F. Usefulness of the aldosterone synthase gene polymorphism C-344-T to predict cardiac remodeling in African-Americans versus non-African-Americans with chronic systolic heart failure. Am J Cardiol. 2007 Jul 15; 100(2):285-90. PMID: 17631084.
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  248. Loscalzo J. Entrepreneurship in the medical academy: possibilities and challenges in commercialization of research discoveries. Circulation. 2007 Mar 27; 115(12):1504-7. PMID: 17389277.
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  249. Leopold JA, Dam A, Maron BA, Scribner AW, Liao R, Handy DE, Stanton RC, Pitt B, Loscalzo J. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med. 2007 Feb; 13(2):189-97. PMID: 17273168; PMCID: PMC3648863.
  250. Letts G, Loscalzo J. Targeting inflammation using novel NO donor. J Am Soc Nephrol. 2007; 18:2863-2869.
  251. Dardik R, Krapp T, Rosenthal E, Loscalzo J, Inbal A. Effect of FXIII on monocyte and fibroblast function. Cell Physiol Biochem. 2007; 19(1-4):113-20. PMID: 17310105.
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  252. Yang Y, Loscalzo J. S-nitrosated proteins: formation, metabolism, and functions. In: Radicals for Life: The Various Forms of Nitric Oxide. Van Faassen E, Vanin AF, editors. 2007; 201-21.
  253. Voetsch B, Jin RC, Bierl C, Benke KS, Kenet G, Simioni P, Ottaviano F, Damasceno BP, Annichino-Bizacchi JM, Handy DE, Loscalzo J. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke. 2007 Jan; 38(1):41-9. PMID: 17122425; PMCID: PMC1781064.
  254. Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res. 2006 Nov 10; 99(10):1044-59. PMID: 17095733.
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  255. Sam F, Halickman I, Vita JA, Levitzky Y, Cupples LA, Loscalzo J, Allensworth-Davies D. Predictors of improved left ventricular systolic function in an urban cardiomyopathy program. Am J Cardiol. 2006 Dec 15; 98(12):1622-6. PMID: 17145222.
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  256. Maron BA, Loscalzo J. Homocysteine. Clin Lab Med. 2006 Sep; 26(3):591-609, vi. PMID: 16938586.
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  257. Maitland K, Bridges L, Davis WP, Loscalzo J, Pointer MA. Different effects of angiotensin receptor blockade on end-organ damage in salt-dependent and salt-independent hypertension. Circulation. 2006 Aug 29; 114(9):905-11. PMID: 16923758.
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  258. Loscalzo J. The NIH budget and the future of biomedical research. N Engl J Med. 2006 Apr 20; 354(16):1665-7. PMID: 16625006.
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  259. Handy DE, Loscalzo J. Nitric oxide and posttranslational modification of the vascular proteome: S-nitrosation of reactive thiols. Arterioscler Thromb Vasc Biol. 2006 Jun; 26(6):1207-14. PMID: 16543494.
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  260. Loscalzo J. Homocysteine trials--clear outcomes for complex reasons. N Engl J Med. 2006 Apr 13; 354(15):1629-32. PMID: 16531615.
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  261. Dardik R, Leor J, Skutelsky E, Castel D, Holbova R, Schiby G, Shaish A, Dickneite G, Loscalzo J, Inbal A. Evaluation of the pro-angiogenic effect of factor XIII in heterotopic mouse heart allografts and FXIII-deficient mice. Thromb Haemost. 2006 Mar; 95(3):546-50. PMID: 16525585.
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  262. Robbins IM, Kawut SM, Yung D, Reilly MP, Lloyd W, Cunningham G, Loscalzo J, Kimmel SE, Christman BW, Barst RJ. A study of aspirin and clopidogrel in idiopathic pulmonary arterial hypertension. Eur Respir J. 2006 Mar; 27(3):578-84. PMID: 16507859.
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  263. Loscalzo J. Joseph Loscalzo, MD, PhD: a conversation with the Editor. Interview by William Clifford Roberts. Am J Cardiol. 2006 Apr 01; 97(7):1110-22. PMID: 16563929.
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  264. Matsui R, Xu S, Maitland KA, Mastroianni R, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):910-6. PMID: 16439706.
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  265. Klings ES, Loscalzo J. Secondary pulmonary hypertension. In: Vascular Medicine: A Companion to Braunwald's Heart Disease. Creager MA, Dzau VJ, Loscalzo J, editors. 2006; 822-31.
  266. Awtry EA, Loscalzo J. Aspirin. In: Platelets, 2nd Edition. Michelson A, editor. 2006; 1099-1125.
  267. Maron BA, Loscalzo J. The role of platelets in fibrinolysis. In: Platelets, 2nd Edition. Michelson A, editor. 2006; 415-30.
  268. Freedman JE, Loscalzo J. Thrombosis. In: Vascular Medicine: A Companion to Braunwald's Heart Disease. Creager MA, Dzau VJ, Loscalzo J, editors. 2006; 125-33.
  269. Loscalzo J. Nitric oxide redux. Arterio Thromb Vasc Biol. 2006; 26:696.
  270. Raiesdana A, Loscalzo J. Pulmonary arterial hypertension. Ann Med. 2006; 38(2):95-110. PMID: 16581695.
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  271. Kane LB, Loscalzo J. Pulmonary arterial hypertension. In: Vascular Medicine: A Companion to Braunwald's Heart Disease. Creager MA, Dzau VJ, Loscalzo J, editors. 2006; 795-821.
  272. Ruberg FL, Loscalzo J. Normal mechanisms of hemostasis. In: Vascular Medicine: A Companion to Braunwald's Heart Disease. Creager MA, Dzau VJ, Loscalzo J, editors. 2006; 61-9.
  273. Galasso G, Schiekofer S, Sato K, Shibata R, Handy DE, Ouchi N, Leopold JA, Loscalzo J, Walsh K. Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ Res. 2006 Feb 03; 98(2):254-61. PMID: 16373599; PMCID: PMC1472658.
  274. Handy DE, Hang G, Scolaro J, Metes N, Razaq N, Yang Y, Loscalzo J. Aminoglycosides decrease glutathione peroxidase-1 activity by interfering with selenocysteine incorporation. J Biol Chem. 2006 Feb 10; 281(6):3382-8. PMID: 16354666; PMCID: PMC1472404.
  275. Ruberg FL, Viereck J, Phinikaridou A, Qiao Y, Loscalzo J, Hamilton JA. Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS. J Lipid Res. 2006 Feb; 47(2):310-7. PMID: 16317172.
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  276. Loscalzo J. Clinical trials in cardiovascular medicine in an era of marginal benefit, bias, and hyperbole. Circulation. 2005 Nov 15; 112(20):3026-9. PMID: 16286598.
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  277. Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, Wagner DD. Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood. 2006 Jan 15; 107(2):591-3. PMID: 16189268; PMCID: PMC1895614.
  278. Dardik R, Loscalzo J, Inbal A. Factor XIII (FXIII) and angiogenesis. J Thromb Haemost. 2006 Jan; 4(1):19-25. PMID: 16129024.
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  279. Antman EM, DeMets D, Loscalzo J. Cyclooxygenase inhibition and cardiovascular risk. Circulation. 2005 Aug 02; 112(5):759-70. PMID: 16061757.
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  280. Song Y, Jones JE, Beppu H, Keaney JF, Loscalzo J, Zhang YY. Increased susceptibility to pulmonary hypertension in heterozygous BMPR2-mutant mice. Circulation. 2005 Jul 26; 112(4):553-62. PMID: 16027259; PMCID: PMC1472405.
  281. Matsui R, Xu S, Maitland KA, Hayes A, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation. 2005 Jul 12; 112(2):257-63. PMID: 15998684.
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  282. Jin RC, Voetsch B, Loscalzo J. Endogenous mechanisms of inhibition of platelet function. Microcirculation. 2005 Apr-May; 12(3):247-58. PMID: 15814434.
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  283. Zhang Y, Handy DE, Loscalzo J. Adenosine-dependent induction of glutathione peroxidase 1 in human primary endothelial cells and protection against oxidative stress. Circ Res. 2005 Apr 29; 96(8):831-7. PMID: 15802613.
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  284. Leopold JA, Loscalzo J. Oxidative enzymopathies and vascular disease. Arterioscler Thromb Vasc Biol. 2005 Jul; 25(7):1332-40. PMID: 15790928.
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  285. Benjamin IJ, Arnett DK, Loscalzo J. Discovering the full spectrum of cardiovascular disease: Minority Health Summit 2003: report of the Basic Science Writing Group. Circulation. 2005 Mar 15; 111(10):e120-3. PMID: 15769753.
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  286. Loscalzo J, Voetsch B, Liao R, Leopold J. Genetic determinants of vascular oxidant stress and endothelial dysfunction. Congest Heart Fail. 2005 Mar-Apr; 11(2):73-9. PMID: 15860972.
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  287. Handy DE, Zhang Y, Loscalzo J. Homocysteine down-regulates cellular glutathione peroxidase (GPx1) by decreasing translation. J Biol Chem. 2005 Apr 22; 280(16):15518-25. PMID: 15734734.
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  288. Farber HW, Loscalzo J. Mechanism of disease: Pulmonary hypertension. Discov Med. 2005 Feb; 5(25):80-7. PMID: 20704929.
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  289. Freedman JE, Loscalzo J. Thrombosis and atherosclerosis. In: Molecular Mechanisms of Atherosclerosis. Loscalzo J. 2005; 85-94.
  290. Gokce N, Carr J, Loscalzo J. Vascular biology and pathobiology in acute coronary syndromes. In: Clinical, Interventional, and Investigational Thrombocardiology. Becker RC, Harrington RA, editors. 2005; 55-72.
  291. Napoli C, Loscalzo J. New challenges for ACE-inhibitors in vascular disease. Drug Design Reviews-Online. 2005; 2(7):485-93.
  292. Loscalzo J. Introduction and overview. In: Molecular Mechanisms of Atherosclerosis. Loscalzo J, editor. 2005; 1.
  293. Leopold JA, Loscalzo J. Rational contemporary molecular and cell-based therapies. In: Molecular Mechanisms of Atherosclerosis. Loscalzo J, editor. 2005; 261-82.
  294. Farber HW, Loscalzo J. Mechanism of disease: pulmonary hypertension. Disc Med. 2005; 25:80-7.
  295. Ruberg FL, Loscalzo J. Inflammation and atherothrombosis. In: Molecular Mechanisms of Atherosclerosis. Loscalzo J, editor. 2005; 45-60.
  296. Loscalzo J. Homocysteine, oxidative stress, and atherothrombosis. In: Proceedings of the 4th International Conference on Homocysteine Metabolism. Fowler B, editor. 2005; 69-74.
  297. Loscalzo J. Editor's note. Circulation. 2005; 112:2.
  298. Handy DE, Loscalzo J. Homocysteine and atherogenesis. In: Molecular Mechanisms of Atherosclerosis. Loscalzo J, editor. 2005; 221-36.
  299. Ruberg FL, Loscalzo J. Vascular thromboresistance and the genetics of thrombotic risk. In: Clinical, Interventional, and Investigational Thrombocardiology. Becker RC, Harrington RA, editors. 2005; 31-53.
  300. Loscalzo J. Future directions. In: Molecular Mechanisms of Atherosclerosis. Loscalzo J, editor. 2005; 283-4.
  301. Loscalzo J. Editor's note. Circulation. 2005; 111:382.
  302. Yang Y, Loscalzo J. S-nitrosoprotein formation and localization in endothelial cells. Proc Natl Acad Sci U S A. 2005 Jan 04; 102(1):117-22. PMID: 15618409; PMCID: PMC544053.
  303. Dardik R, Loscalzo J, Eskaraev R, Inbal A. Molecular mechanisms underlying the proangiogenic effect of factor XIII. Arterioscler Thromb Vasc Biol. 2005 Mar; 25(3):526-32. PMID: 15618543.
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  304. Loscalzo J, Bonow RO, Jacobs AK. Coronary calcium screening and the American Heart Association news embargo. Circulation. 2004 Dec 07; 110(23):3504-5. PMID: 15583087.
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  305. Handy DE, Scolaro J, Chen J, Huang P, Loscalzo J. L-arginine increases plasma homocysteine in apoE-/-/iNOS-/- double knockout mice. Cell Mol Biol (Noisy-le-grand). 2004 Dec; 50(8):903-9. PMID: 15704254.
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  306. Jacobs AK, Smith SC, Popp RL, Loscalzo J. Ethics and professionalism: can there be consensus? An editorial comment on the report of the ACCF/AHA Consensus Conference on Professionalism and Ethics. Circulation. 2004 Oct 19; 110(16):2278-9. PMID: 15492327.
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  307. Farber HW, Loscalzo J. Pulmonary arterial hypertension. N Engl J Med. 2004 Oct 14; 351(16):1655-65. PMID: 15483284.
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  308. Loscalzo J. L-arginine and atherothrombosis. J Nutr. 2004 Oct; 134(10 Suppl):2798S-2800S; discussion 2818S-2819S. PMID: 15465788.
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  309. Voetsch B, Jin RC, Loscalzo J. Nitric oxide insufficiency and atherothrombosis. Histochem Cell Biol. 2004 Oct; 122(4):353-67. PMID: 15338226.
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  310. Faxon DP, Creager MA, Smith SC, Pasternak RC, Olin JW, Bettmann MA, Criqui MH, Milani RV, Loscalzo J, Kaufman JA, Jones DW, Pearce WH. Atherosclerotic Vascular Disease Conference: Executive summary: Atherosclerotic Vascular Disease Conference proceeding for healthcare professionals from a special writing group of the American Heart Association. Circulation. 2004 Jun 01; 109(21):2595-604. PMID: 15173041.
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  311. Faxon DP, Fuster V, Libby P, Beckman JA, Hiatt WR, Thompson RW, Topper JN, Annex BH, Rundback JH, Fabunmi RP, Robertson RM, Loscalzo J. Atherosclerotic Vascular Disease Conference: Writing Group III: pathophysiology. Circulation. 2004 Jun 01; 109(21):2617-25. PMID: 15173044.
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  312. Morel NM, Holland JM, van der Greef J, Marple EW, Clish C, Loscalzo J, Naylor S. Primer on medical genomics. Part XIV: Introduction to systems biology--a new approach to understanding disease and treatment. Mayo Clin Proc. 2004 May; 79(5):651-8. PMID: 15132407.
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  313. Bierl C, Voetsch B, Jin RC, Handy DE, Loscalzo J. Determinants of human plasma glutathione peroxidase (GPx-3) expression. J Biol Chem. 2004 Jun 25; 279(26):26839-45. PMID: 15096516.
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  314. Voetsch B, Loscalzo J. Genetics of thrombophilia: impact on atherogenesis. Curr Opin Lipidol. 2004 Apr; 15(2):129-43. PMID: 15017356.
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  315. Heydrick SJ, Weiss N, Thomas SR, Cap AP, Pimentel DR, Loscalzo J, Keaney JF. L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells. Free Radic Biol Med. 2004 Mar 01; 36(5):632-40. PMID: 14980706.
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  316. Napoli C, Loscalzo J. Nitric oxide and other novel therapies for pulmonary hypertension. J Cardiovasc Pharmacol Ther. 2004 Mar; 9(1):1-8. PMID: 15094962.
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  317. Voetsch B, Benke KS, Panhuysen CI, Damasceno BP, Loscalzo J. The combined effect of paraoxonase promoter and coding region polymorphisms on the risk of arterial ischemic stroke among young adults. Arch Neurol. 2004 Mar; 61(3):351-6. PMID: 15023811.
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  318. Loscalzo J. Ozone--from environmental pollutant to atherogenic determinant. N Engl J Med. 2004 Feb 19; 350(8):834-5. PMID: 14973208.
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  319. Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004 Feb 24; 109(7):898-903. PMID: 14757696.
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  320. Jones JE, Walker JL, Song Y, Weiss N, Cardoso WV, Tuder RM, Loscalzo J, Zhang YY. Effect of 5-lipoxygenase on the development of pulmonary hypertension in rats. Am J Physiol Heart Circ Physiol. 2004 May; 286(5):H1775-84. PMID: 14726295.
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  321. Loscalzo J. James T. Willerson, M.D., editor of circulation, 1993-2004: a note of appreciation. Circulation. 2004; 110:2.
  322. Loscalzo. Arginine metabolism: enzymology, nutrition,and clinical significance. Session V: therapeutic strategies and supplemental-discussion summary. J Nutr. 2004; 135:2895S.
  323. Morris SM, Loscalzo J. Arginine metabolism: enzymology, nutrition, and clinical significance. Introduction to the symposium proceedings. J Nutr. 2004; 134:2742S.
  324. Loscalzo J, Morris SM. Symposium on arginine: conference summary. J Nutr. 2004; 134:2896S-7S.
  325. Loscalzo J. The eagle's view, or how to use this journal. Circulation. 2004; 110:3.
  326. Feelisch M, Loscalzo J. Nitric oxide donors in cardiovascular disease. In: Nitric Oxide Donors for Pharmaceutical and Biological Applications. Wang PG, Cai TB, Taniguchi N, editors. 2004; 285-98.
  327. Voetsch B, Loscalzo J. Genetic determinants of atherothrombotic disease. In: Recent Advances in Haematology. Choudhry VP, Saxena R, Pati HP, editors. 2004; 275-87.
  328. Loscalzo J. Stem cells and regeneration of the cardiovascular system: facts, fictions, and uncertainties. Blood Cells Mol Dis. 2004 Jan-Feb; 32(1):97-9. PMID: 14757421.
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  329. Scribner AW, Loscalzo J, Napoli C. The effect of angiotensin-converting enzyme inhibition on endothelial function and oxidant stress. Eur J Pharmacol. 2003 Dec 15; 482(1-3):95-9. PMID: 14660009.
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  330. Manger WM, Simchon S, Stier CT, Loscalzo J, Jan KM, Jan R, Haddy F. Protective effects of dietary potassium chloride on hemodynamics of Dahl salt-sensitive rats in response to chronic administration of sodium chloride. J Hypertens. 2003 Dec; 21(12):2305-13. PMID: 14654751.
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  331. Voetsch B, Loscalzo J. Genetic determinants of arterial thrombosis. Arterioscler Thromb Vasc Biol. 2004 Feb; 24(2):216-29. PMID: 14615395.
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  332. Walford GA, Moussignac RL, Scribner AW, Loscalzo J, Leopold JA. Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways. J Biol Chem. 2004 Feb 06; 279(6):4425-32. PMID: 14597620.
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  333. Weiss N, Heydrick SJ, Postea O, Keller C, Keaney JF, Loscalzo J. Influence of hyperhomocysteinemia on the cellular redox state--impact on homocysteine-induced endothelial dysfunction. Clin Chem Lab Med. 2003 Nov; 41(11):1455-61. PMID: 14656025.
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  334. Loscalzo J. The evolution of the discipline of vascular biology: from systems physiology to molecular biology to molecular systems. Circ Res. 2003 Oct 03; 93(7):583-5. PMID: 14525918.
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  335. Eberhardt RT, McMahon L, Duffy SJ, Steinberg MH, Perrine SP, Loscalzo J, Coffman JD, Vita JA. Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels. Am J Hematol. 2003 Oct; 74(2):104-11. PMID: 14508796.
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  336. Walford G, Loscalzo J. Nitric oxide in vascular biology. J Thromb Haemost. 2003 Oct; 1(10):2112-8. PMID: 14521592.
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  337. Loscalzo J. Oxidant stress: a key determinant of atherothrombosis. Biochem Soc Trans. 2003 Oct; 31(Pt 5):1059-61. PMID: 14505479.
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  338. Cohn JN, Loscalzo J, Franciosa JA. Nitric oxide's role in heart failure: pathophysiology and treatment. Introduction. J Card Fail. 2003 Oct; 9(5 Suppl Nitric Oxide):S197-8. PMID: 14653276.
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  339. Leopold JA, Loscalzo J. Organic nitrate tolerance and endothelial dysfunction: role of folate therapy. Minerva Cardioangiol. 2003 Aug; 51(4):349-59. PMID: 12900717.
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  340. Loscalzo J. Proteomics in cardiovascular biology and medicine. Circulation. 2003 Jul 29; 108(4):380-3. PMID: 12885729.
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  341. Forde P, Scribner AW, Dial R, Loscalzo J, Trolliet MR. Prevention of hypertension and renal dysfunction in Dahl rats by alpha-tocopherol. J Cardiovasc Pharmacol. 2003 Jul; 42(1):82-8. PMID: 12827031.
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  342. Handy DE, Loscalzo J. Homocysteine and atherothrombosis: diagnosis and treatment. Curr Atheroscler Rep. 2003 Jul; 5(4):276-83. PMID: 12793968.
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  343. Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res. 2003 Jul 25; 93(2):e9-16. PMID: 12829617.
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  344. Dardik R, Solomon A, Loscalzo J, Eskaraev R, Bialik A, Goldberg I, Schiby G, Inbal A. Novel proangiogenic effect of factor XIII associated with suppression of thrombospondin 1 expression. Arterioscler Thromb Vasc Biol. 2003 Aug 01; 23(8):1472-7. PMID: 12805075.
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  345. Freedman JE, Loscalzo J. Nitric oxide and its relationship to thrombotic disorders. J Thromb Haemost. 2003 Jun; 1(6):1183-8. PMID: 12871317.
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  346. Leopold JA, Walker J, Scribner AW, Voetsch B, Zhang YY, Loscalzo AJ, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):32100-6. PMID: 12777375.
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  347. Nedeljkovic ZS, Gokce N, Loscalzo J. Mechanisms of oxidative stress and vascular dysfunction. Postgrad Med J. 2003 Apr; 79(930):195-199; quiz 198-200. PMID: 12743334; PMCID: PMC1742679.
  348. Loscalzo J. Functional polymorphisms in a candidate gene for atherothrombosis: unraveling the complex fabric of a polygenic phenotype. J Am Coll Cardiol. 2003 Mar 19; 41(6):946-8. PMID: 12651038.
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  349. Leopold JA, Zhang YY, Scribner AW, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide. Arterioscler Thromb Vasc Biol. 2003 Mar 01; 23(3):411-7. PMID: 12615686.
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  350. Eisenberg MS, Rabbani LE, Loscalzo J. The relationship between thrombosis and atherosclerosis. In: Thrombosis and Hemorrhage, 3rd Edition. Loscalzo J, Schafer AI, editors. 2003; 628-47.
  351. Gocke N, Loscalzo J. The endothelium in atherothrombosis. In: Atlas of Atherosclerosis: Risk Factors and Treatment. Wilson PWF, editor. 2003; 21-40.
  352. Handy DE, Loscalzo J. Homocysteine and atherothrombosis: diagnosis and treatment. Curr thero Rep. 2003; 5:276-83.
  353. Leopold JA, Loscalzo J. The pharmacology of thrombolytic agents. In: Thrombosis and Hemorrhage, 3rd Edition. Loscalzo J, Schafer AI, editors. 2003; 949-77.
  354. Mendes LA, Loscalzo J. Acquired valvular heart disease. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo J, editors. 2003; 77-85.
  355. Awtry E, Loscalzo J. An overview of platelet inhibitor agents. In: Handbook of Antiplatelet Therapy. Cohen M, editor. 2003; 83-96.
  356. Mendes LA, Loscalzo J. Heart failure and cardiomyopathy. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo J, editors. 2003; 63-70.
  357. Loscalzo J. Adverse effects of supplemental L-arginine in atherosclerosis: consequences of methylation stress in a complex catabolism? Arterioscler Thromb Vasc Biol. 2003 Jan 01; 23(1):3-5. PMID: 12524215.
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  358. Loscalzo J. S-nitrosothiols in cell signaling. In: Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles. Forman HJ, Fukuto J, Torres M, editors. 2003; 155-66.
  359. Sharis PJ, Loscalzo J. Thienopyridines: ticlopidine and clopidogrel. In: New Therapeutic Agents in Thrombosis and Thrombolysis, 2nd Edition. Sasahara AA, Loscalzo J, editors. 2003; 431-49.
  360. Loscalzo J, Schafer AI. Overview of hemostasis and fibrinolysis. In: New Therapeutic Agents in Thrombosis and Thrombolysis, 2nd Edition. Sasahara AA, Loscalzo J, editors. 2003; 1-7.
  361. Voetsch B, Afshar-Kharghan V, Loscalzo J, Schafer A. Less common thrombotic and embolic disorders. In: Thrombosis and Hemorrhage, 3rd Edition. Loscalzo, J, Schafer AI, editors. 2003; 707-62.
  362. Awtry EH, Loscalzo J. Coronary heart disease. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo. 2003; 87-108.
  363. Leopold JA, Loscalzo J. Markers of a thrombotic state. In: Acute Coronary Syndromes. Theroux P. editor. 2003; 197-203.
  364. Mendes LA, Loscalzo J. Myocardial and pericardial disease. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo J, editors. 2003; 137-46.
  365. Mendes LA, Loscalzo J. Diagnostic tests and procedures in the patient with cardiovascular disease. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo J, editors. 2003; 47-61.
  366. Mendes LA, Loscalzo J. Other cardiac topics. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo J, editors. 2003; 147-54.
  367. Awtry EH, Loscalzo J. Evaluation of the patient with cardiovascular disease. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo. 2003; 33-45.
  368. Awtry EH, Loscalzo J. Structure and function of the normal heart and blood vessels. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo. 2003; 23-31.
  369. Awtry EH, Loscalzo J. Cardiac arrhythmias. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo. 2003; 109-35.
  370. Freedman JE, Loscalzo J. New antithrombotic strategies. In: Thrombosis and Hemorrhage, 3rd Edition. Loscalzo J, Schafer, AI, editors. 2003; 978-95.
  371. Ruberg FL, Loscalzo J. Prothrombotic determinants of coronary atherothrombosis. Vasc Med. 2003; 7:289-99.
  372. Awtry EH, Loscalzo J. Vascular diseases and hypertension. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo. 2003; 155-73.
  373. Mendes LA, Loscalzo J. Congenital heart disease. In: Cecil Essentials of Medicine, 6th Edition. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo J, editors. 2003; 71-6.
  374. Willoughby S, Holmes A, Loscalzo J. Platelets and cardiovascular disease. Eur J Cardiovasc Nurs. 2002 Dec; 1(4):273-88. PMID: 14622657.
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  375. Roberts R, Bonow RO, Loscalzo J, Mosca L. Report of the American Heart Association Task Force on Strategic Research Direction: executive summary. Circulation. 2002 Nov 12; 106(20):2630-2. PMID: 12427662.
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  376. Loscalzo J, Balaban R, Becker LB, Ginsburg GS, Hachinski VC, Hall JE, Heistad DD, Leinwand LA, Lenfant CJ, Marban E, Olson EN, Schwartz SM. Task Force on Strategic Research Direction: Basic Science Subgroup key science topics report. Circulation. 2002 Nov 12; 106(20):e149-61. PMID: 12427670.
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  377. Napoli C, Lerman LO, de Nigris F, Loscalzo J, Ignarro LJ. Glycoxidized low-density lipoprotein downregulates endothelial nitricoxide synthase in human coronary cells. J Am Coll Cardiol. 2002 Oct 16; 40(8):1515-22. PMID: 12392844.
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  378. Tawakol A, Forgione MA, Stuehlinger M, Alpert NM, Cooke JP, Loscalzo J, Fischman AJ, Creager MA, Gewirtz H. Homocysteine impairs coronary microvascular dilator function in humans. J Am Coll Cardiol. 2002 Sep 18; 40(6):1051-58. PMID: 12354427.
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  379. Loscalzo J. Oxidative stress in endothelial cell dysfunction and thrombosis. Pathophysiol Haemost Thromb. 2002 Sep-Dec; 32(5-6):359-60. PMID: 13679676.
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  380. Forgione MA, Cap A, Liao R, Moldovan NI, Eberhardt RT, Lim CC, Jones J, Goldschmidt-Clermont PJ, Loscalzo J. Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation. 2002 Aug 27; 106(9):1154-8. PMID: 12196344.
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  381. Kahn DF, Duffy SJ, Tomasian D, Holbrook M, Rescorl L, Russell J, Gokce N, Loscalzo J, Vita JA. Effects of black race on forearm resistance vessel function. Hypertension. 2002 Aug; 40(2):195-201. PMID: 12154113.
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  382. Weiss N, Keller C, Hoffmann U, Loscalzo J. Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vasc Med. 2002 Aug; 7(3):227-39. PMID: 12553746.
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  383. Vita JA, Loscalzo J. Shouldering the risk factor burden: infection, atherosclerosis, and the vascular endothelium. Circulation. 2002 Jul 09; 106(2):164-6. PMID: 12105150.
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  384. Jones JE, Mendes L, Rudd MA, Russo G, Loscalzo J, Zhang YY. Serial noninvasive assessment of progressive pulmonary hypertension in a rat model. Am J Physiol Heart Circ Physiol. 2002 Jul; 283(1):H364-71. PMID: 12063310.
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  385. Voetsch B, Benke KS, Damasceno BP, Siqueira LH, Loscalzo J. Paraoxonase 192 Gln-->Arg polymorphism: an independent risk factor for nonfatal arterial ischemic stroke among young adults. Stroke. 2002 Jun; 33(6):1459-64. PMID: 12052975.
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  386. Franciosa JA, Taylor AL, Cohn JN, Yancy CW, Ziesche S, Olukotun A, Ofili E, Ferdinand K, Loscalzo J, Worcel M. African-American Heart Failure Trial (A-HeFT): rationale, design, and methodology. J Card Fail. 2002 Jun; 8(3):128-35. PMID: 12140804.
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  387. Freedman JE, Loscalzo J. Platelet-monocyte aggregates: bridging thrombosis and inflammation. Circulation. 2002 May 07; 105(18):2130-2. PMID: 11994242.
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  388. Russo G, Leopold JA, Loscalzo J. Vasoactive substances: nitric oxide and endothelial dysfunction in atherosclerosis. Vascul Pharmacol. 2002 May; 38(5):259-69. PMID: 12487030.
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  389. Sawyer DB, Loscalzo J. Myocardial hibernation: restorative or preterminal sleep? Circulation. 2002 Apr 02; 105(13):1517-9. PMID: 11927510.
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  390. Forgione MA, Weiss N, Heydrick S, Cap A, Klings ES, Bierl C, Eberhardt RT, Farber HW, Loscalzo J. Cellular glutathione peroxidase deficiency and endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2002 Apr; 282(4):H1255-61. PMID: 11893559.
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  391. Ruberg FL, Leopold JA, Loscalzo J. Atherothrombosis: plaque instability and thrombogenesis. Prog Cardiovasc Dis. 2002 Mar-Apr; 44(5):381-94. PMID: 12024336.
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  392. Loscalzo J. Homocysteine and dementias. N Engl J Med. 2002 Feb 14; 346(7):466-8. PMID: 11844846.
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  393. Walker JL, Loscalzo J, Zhang YY. 5-Lipoxygenase and human pulmonary artery endothelial cell proliferation. Am J Physiol Heart Circ Physiol. 2002 Feb; 282(2):H585-93. PMID: 11788406.
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  394. Zhang YY, Walker JL, Huang A, Keaney JF, Clish CB, Serhan CN, Loscalzo J. Expression of 5-lipoxygenase in pulmonary artery endothelial cells. Biochem J. 2002 Jan 15; 361(Pt 2):267-76. PMID: 11772398; PMCID: PMC1222306.
  395. Ignarro LJ, Napoli C, Loscalzo J. Nitric oxide donors and cardiovascular agents modulating the bioactivity of nitric oxide: an overview. Circ Res. 2002 Jan 11; 90(1):21-8. PMID: 11786514.
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  396. Weiss N, Heydrick S, Zhang YY, Bierl C, Cap A, Loscalzo J. Cellular redox state and endothelial dysfunction in mildly hyperhomocysteinemic cystathionine beta-synthase-deficient mice. Arterioscler Thromb Vasc Biol. 2002 Jan; 22(1):34-41. PMID: 11788458.
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  397. Ruberg FL, Loscalzo J. Prothrombotic determinants of coronary atherothrombosis. Vasc Med. 2002; 7(4):289-99. PMID: 12710845.
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  398. Chaves C, Voetsch B, Loscalzo J, Caplan L, Chavali R. Extensive cerebral venous thrombosis associated with moderate hyperhomocyst(e)inemia and successfully treated with thrombolysis. Cerebrovasc Dis. 2002; 13(3):214-6. PMID: 11914541.
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  399. Awtry EH, Loscalzo J. Aspirin. In: Platelets. Michelson AD, editor. 2002; 745-68.
  400. Loscalzo J. Homocysteine in health and disease (book review). N Engl J Med. 2002; 346:385.
  401. Willoubhby S, Loscalzo J. Vascular control of platelet function. In: Platelets in Thrombotic and Non-thrombotic Disorders: Pathophysiology, Pharmacology, and Treatment. Gresele P, Page CP, Vermylen J, Fuster V, editors. 2002; 432-55.
  402. Voetsch B, Loscalzo J. Homocysteine MTHFR677C6T polymorphism, and ischemic stroke risk. J Watch Neuro. 2002; 4:90-1.
  403. Battinelli E, Willoughby SR, Foxall T, Valeri CR, Loscalzo J. Induction of platelet formation from megakaryocytoid cells by nitric oxide. Proc Natl Acad Sci U S A. 2001 Dec 04; 98(25):14458-63. PMID: 11734646; PMCID: PMC64703.
  404. Gokce N, Holbrook M, Duffy SJ, Demissie S, Cupples LA, Biegelsen E, Keaney JF, Loscalzo J, Vita JA. Effects of race and hypertension on flow-mediated and nitroglycerin-mediated dilation of the brachial artery. Hypertension. 2001 Dec 01; 38(6):1349-54. PMID: 11751716.
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  405. Weiss N, Zhang YY, Heydrick S, Bierl C, Loscalzo J. Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction. Proc Natl Acad Sci U S A. 2001 Oct 23; 98(22):12503-8. PMID: 11606774; PMCID: PMC60083.
  406. Loscalzo J. Folate and nitrate-induced endothelial dysfunction: a simple treatment for a complex pathobiology. Circulation. 2001 Sep 04; 104(10):1086-8. PMID: 11535558.
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  407. Loscalzo J. An experiment of nature: genetic L-arginine deficiency and NO insufficiency. J Clin Invest. 2001 Sep; 108(5):663-4. PMID: 11544270; PMCID: PMC209388.
  408. Loscalzo J. Salt-sensitive hypertension and inducible nitric oxide synthase: form-function dichotomy of a coding region mutation, Mutatis mutandis. Circ Res. 2001 Aug 17; 89(4):292-4. PMID: 11509443.
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  409. Loscalzo J. Genetic clues to the cause of primary pulmonary hypertension. N Engl J Med. 2001 Aug 02; 345(5):367-71. PMID: 11484696.
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  410. Loscalzo J. Inducible NO synthesis in the vasculature: molecular context defines physiological response. Arterioscler Thromb Vasc Biol. 2001 Aug; 21(8):1259-60. PMID: 11498449.
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  411. Valeri CR, Cassidy G, Pivacek LE, Ragno G, Lieberthal W, Crowley JP, Khuri SF, Loscalzo J. Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss. Transfusion. 2001 Aug; 41(8):977-83. PMID: 11493727.
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  412. Leopold JA, Cap A, Scribner AW, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability. FASEB J. 2001 Aug; 15(10):1771-3. PMID: 11481225.
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  413. Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res. 2001 Apr 27; 88(8):756-62. PMID: 11325866.
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  414. Loscalzo J. Resolution of platelet-rich thrombi in essential thrombocythemia: mechanisms, risks, and benefits of antiplatelet therapy. Mayo Clin Proc. 2001 Apr; 76(4):356-7. PMID: 11322349.
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  415. Upchurch GR, Goodman DG, Willoughby SR, Zhang YY, Welch GN, Freedman JE, Ye S, Costello CE, Loscalzo J. Heparin reacts with and inactivates nitric oxide. J Cardiovasc Pharmacol Ther. 2001 Apr; 6(2):163-73. PMID: 11509923.
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  416. Loscalzo J. The tangled web of heart failure: a complex network of surrogates and correlates. J Cardiovasc Electrophysiol. 2001 Mar; 12(3):301-2. PMID: 11291802.
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  417. Halle DA, Loscalzo J. Lipid disorders: diagnosis, management, and controversy. In: Textbook of Primary Care. Noble J, editor. 2001; 634-53.
  418. Trolliet MR, Rudd MA, Loscalzo J. Oxidative stress and renal dysfunction in salt-sensitive hypertension. Kidney Blood Press Res. 2001; 24(2):116-23. PMID: 11435744.
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  419. Freedman JE, Loscalzo J. Fibrinolytic and antithrombotic therapy of peripheral vascular, cerebrovascular, and intracardiac disorders. In: Cardiovascular Therapeutics, 2nd Edition. Antman, EM, Colucci, WS, Gotto, AM, Josephson, ME, Loscalzo J, Oparil S, Popma JJ, editors. 2001; 695-703.
  420. Leopold JA, Loscalzo J. Cyclic strain modulates resistance to oxidant stress by increasing G6PDH expression in smooth muscle cells. Am J Physiol Heart Circ Physiol. 2000 Nov; 279(5):H2477-85. PMID: 11045985.
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  421. Forgione MA, Loscalzo J. Oxidant stress as a critical determinant of endothelial function. Drug News Perspect. 2000 Nov; 13(9):523-9. PMID: 12879123.
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  422. Forgione MA, Leopold JA, Loscalzo J. Roles of endothelial dysfunction in coronary artery disease. Curr Opin Cardiol. 2000 Nov; 15(6):409-15. PMID: 11198623.
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  423. Zhang YY, Hammarberg T, Radmark O, Samuelsson B, Ng CF, Funk CD, Loscalzo J. Analysis of a nucleotide-binding site of 5-lipoxygenase by affinity labelling: binding characteristics and amino acid sequences. Biochem J. 2000 Nov 01; 351 Pt 3:697-707. PMID: 11042125; PMCID: PMC1221410.
  424. Gurevitz O, Eldar M, Skutelsky E, Tamarin I, Shenkman B, Eskaraev R, Castel D, Loscalzo J, Inbal A. S-nitrosoderivative of a recombinant fragment of von Willebrand factor (S-nitroso-AR545C) inhibits thrombus formation in guinea pig carotid artery thrombosis model. Thromb Haemost. 2000 Nov; 84(5):912-7. PMID: 11127876.
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  425. Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, Heydrick S, Stark R, Klings ES, Moldovan NI, Yaghoubi M, Goldschmidt-Clermont PJ, Farber HW, Cohen R, Loscalzo J. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest. 2000 Aug; 106(4):483-91. PMID: 10953023; PMCID: PMC380245.
  426. Battinelli E, Loscalzo J. Nitric oxide induces apoptosis in megakaryocytic cell lines. Blood. 2000 Jun 01; 95(11):3451-9. PMID: 10828028.
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  427. Loscalzo J. What we know and don't know about L-arginine and NO. Circulation. 2000 May 09; 101(18):2126-9. PMID: 10801749.
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  428. Yang Y, Loscalzo J. Regulation of tissue factor expression in human microvascular endothelial cells by nitric oxide. Circulation. 2000 May 09; 101(18):2144-8. PMID: 10801753.
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  429. Awtry EH, Loscalzo J. Aspirin. Circulation. 2000 Mar 14; 101(10):1206-18. PMID: 10715270.
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  430. Leopold JA, Loscalzo J. Clinical importance of understanding vascular biology. Cardiol Rev. 2000 Mar-Apr; 8(2):115-23. PMID: 11174883.
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  431. Loscalzo J. Vascular matrix and vein graft failure. Is the message in the medium? Circulation. 2000 Jan 25; 101(3):221-3. PMID: 10645913.
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  432. Loscalzo J, Freedman J, Inbal A, Keaney JF, Michelson AD, Vita JA. Nitric oxide insufficiency and arterial thrombosis. Trans Am Clin Climatol Assoc. 2000; 111:158-63. PMID: 10881340; PMCID: PMC2194373.
  433. Mendes LA, Loscalzo J. Diagnostic tests and procedures in the patient with cardiovascular disease. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 43-55.
  434. Mendes LA, Loscalzo J. Heart failure and cardiomyopathy. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 56-62.
  435. Battinelli EM, Loscalzo J. Nitric oxide and platelet-mediated hemostasis. In: Nitric Oxide and the Cardiovascular System. Loscalzo J, Vita JA, editors. 2000; 123-38.
  436. Eberhardt RT, Loscalzo J. Homocysteine and endothelial dysfunction. In: Homocysteine and Vascular Disease. Robinson K, editor. 2000; 371-87.
  437. Rudd, MA, Trolliet M, Loscalzo J. Nitric oxide and hypertension. In: Nitric Oxide and the Cardiovascular System. Loscalzo J, Vita VA, editors. 2000; 227-46.
  438. Freedman JE, Loscalzo J. Thrombotic disorders and nitric oxide insufficiency. In: Nitric Oxide and the Cardiovascular System. Loscalzo J, Vita JA, editors. 2000; 297-307.
  439. Upchurch GE, Loscalzo J. Nitric oxide and vascular disease. In: Current Therapy in Vascular Surgery. Ernst CB, Stanley JC, editors. 2000; 365-7.
  440. Loscalzo J. Homocysteine and atherothrombotic vascular disease. J Thromb Thrombolysis. 2000; 9:125-6.
  441. Eberhardt RT, Loscalzo J. Nitric oxide in atherosclerosis. In: Nitric Oxide and the Cardiovascular System. Loscalzo J, Vita JA, editors. 2000; 273-95.
  442. Mendes LA, Loscalzo J. Other cardiac topics. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 137-44.
  443. Awtry EH, Loscalzo J. Evaluation of the patient with cardiovascular disease. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 30-42.
  444. Awtry EH, Loscalzo J. Structure and function of the normal heart and blood vessels. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo J, editors. 2000; 21-9.
  445. Mendes LA, Loscalzo J. Congenital heart disease. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 63-8.
  446. Awtry EH, Loscalzo J. Vascular diseases and hypertension. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 145-63.
  447. Gocke N, Loscalzo J. Endothelial dysfunction and atherothrombosis. In: Atlas of Atherosclerosis: Risk Factors and Treatment. Wilson PWF, editor. 2000; 21-40.
  448. Leopold JA, Loscalzo J. S-Nitrosothiols. In: Nitric Oxide and the Cardiovascular System. Loscalzo J, Vita JA, editors. 2000; 411-29.
  449. Glassburg J, Loscalzo J. Endothelial function in end-stage renal failure. In: Cardiovascular Disease in End-stage Renal Failure. Loscalzo J, London GM, editors. 2000; 117-55.
  450. Mendes LA, Loscalzo J. Myocardial and pericardial disease. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 127-36.
  451. Loscalzo J. Endothelium, nitric oxide, and atherosclerosis: from basic mechanisms to clinical implications. Circulation. 2000; 102:e51.
  452. Folts JD, Loscalzo J. Coating arterial and blood-contacting surfaces with NO°- donating compounds. In: Nitric Oxide and the Cardiovascular System. Loscalzo J, Vita JA, editors. 2000; 503-14.
  453. Loscalzo J. The biological chemistry of nitric oxide. In: Nitric Oxide and the Cardiovascular System. Loscalzo J, Vita VA, editors. 2000; 3-10.
  454. Awtry EH, Loscalzo J. Cardiac arrhythmias. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 100-26.
  455. Loscalzo J. The molecular basis of human disease. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs RC, Loscalzo J, editors. 2000; 3-12.
  456. Mendes LA, Loscalzo J. Acquired valvular heart disease. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 69-78.
  457. Awtry EH, Loscalzo J. Coronary heart disease. In: Cecil Essentials of Medicine. Andreoli TE, Carpenter CCJ, Griggs, RC, Loscalzo J, editors. 2000; 79-99.
  458. Farber HW, Loscalzo J. Prothrombotic mechanisms in primary pulmonary hypertension. J Lab Clin Med. 1999 Dec; 134(6):561-6. PMID: 10595782.
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  459. Hammerman SI, Klings ES, Hendra KP, Upchurch GR, Rishikof DC, Loscalzo J, Farber HW. Endothelial cell nitric oxide production in acute chest syndrome. Am J Physiol. 1999 Oct; 277(4 Pt 2):H1579-92. PMID: 10516198.
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  460. Maytin M, Leopold J, Loscalzo J. Oxidant stress in the vasculature. Curr Atheroscler Rep. 1999 Sep; 1(2):156-64. PMID: 11122705.
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  461. Inbal A, Gurevitz O, Tamarin I, Eskaraev R, Chetrit A, Novicov I, Feldman M, Varon D, Eldar M, Loscalzo J. Unique antiplatelet effects of a novel S-nitrosoderivative of a recombinant fragment of von Willebrand factor, AR545C: in vitro and ex vivo inhibition of platelet function. Blood. 1999 Sep 01; 94(5):1693-700. PMID: 10477694.
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  462. Kenet G, Freedman J, Shenkman B, Regina E, Brok-Simoni F, Holzman F, Vavva F, Brand N, Michelson A, Trolliet M, Loscalzo J, Inbal A. Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke. Arterioscler Thromb Vasc Biol. 1999 Aug; 19(8):2017-23. PMID: 10446087.
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  463. Rudd MA, Trolliet M, Hope S, Scribner AW, Daumerie G, Toolan G, Cloutier T, Loscalzo J. Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition. Am J Physiol. 1999 Aug; 277(2 Pt 2):H732-9. PMID: 10444500.
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  464. Price DT, Loscalzo J. Cellular adhesion molecules and atherogenesis. Am J Med. 1999 Jul; 107(1):85-97. PMID: 10403357.
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  465. Freedman JE, Sauter R, Battinelli EM, Ault K, Knowles C, Huang PL, Loscalzo J. Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res. 1999 Jun 25; 84(12):1416-21. PMID: 10381894.
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  466. Biegelsen ES, Loscalzo J. Endothelial function and atherosclerosis. Coron Artery Dis. 1999 Jun; 10(4):241-56. PMID: 10376203.
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  467. Pigazzi A, Heydrick S, Folli F, Benoit S, Michelson A, Loscalzo J. Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets. J Biol Chem. 1999 May 14; 274(20):14368-75. PMID: 10318860.
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  468. Maalej N, Albrecht R, Loscalzo J, Folts JD. The potent platelet inhibitory effects of S-nitrosated albumin coating of artificial surfaces. J Am Coll Cardiol. 1999 Apr; 33(5):1408-14. PMID: 10193746.
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  469. Lieberthal W, Fuhro R, Freedman JE, Toolan G, Loscalzo J, Valeri CR. O-raffinose cross-linking markedly reduces systemic and renal vasoconstrictor effects of unmodified human hemoglobin. J Pharmacol Exp Ther. 1999 Mar; 288(3):1278-87. PMID: 10027869.
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  470. Zai A, Rudd MA, Scribner AW, Loscalzo J. Cell-surface protein disulfide isomerase catalyzes transnitrosation and regulates intracellular transfer of nitric oxide. J Clin Invest. 1999 Feb; 103(3):393-9. PMID: 9927500; PMCID: PMC407899.
  471. Folts JD, Schafer AI, Loscalzo J, Willerson JT, Muller JE. A perspective on the potential problems with aspirin as an antithrombotic agent: a comparison of studies in an animal model with clinical trials. J Am Coll Cardiol. 1999 Feb; 33(2):295-303. PMID: 9973006.
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  472. Keaney JF, Loscalzo J. Diabetes, oxidative stress, and platelet activation. Circulation. 1999 Jan 19; 99(2):189-91. PMID: 9892579.
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  473. Leopold JA, Loscalzo J. Vascular smooth muscle cell biology and restenosis. In: Applications of Antisense Therapies to Restenosis. Rabbani LE, editor. 1999; 45-69.
  474. Leopold JA, Loscalzo J. Platelets and fibrinolysis. In: Platelets, Thrombosis and the Vessel Wall. Berndt MC, editor. 1999; 21-38.
  475. Battinelli EM, Trolliet MR, Loscalzo j. Nitric oxide and its role in hemostasis. In: Pathophysiology and Clinical Applications of Nitric Oxide, Part B. Rubanyi GM, editor. 1999; 229-49.
  476. Zhang Y, Loscalzo J. S-nitroso-proteins. Curr Protocols Toxicol. 1999; 10.3.1-10.3.8.
  477. Freedman JE, Ting B, Hankin B, Loscalzo J, Keaney JF, Vita JA. Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation. 1998 Oct 13; 98(15):1481-6. PMID: 9769300.
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  478. Moraes D, Loscalzo J. Pulmonary hypertension. Drugs Today (Barc). 1998 Oct; 34(10):855-64. PMID: 14743257.
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  479. Sharis PJ, Cannon CP, Loscalzo J. The antiplatelet effects of ticlopidine and clopidogrel. Ann Intern Med. 1998 Sep 01; 129(5):394-405. PMID: 9735068.
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  480. Valeri CR, Crowley JP, Loscalzo J. The red cell transfusion trigger: has a sin of commission now become a sin of omission? Transfusion. 1998 Jun; 38(6):602-10. PMID: 9661695.
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  481. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, Schmidt AM, Stern DM. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 1998 May 15; 91(10):3527-61. PMID: 9572988.
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  482. Welch GN, Loscalzo J. Homocysteine and atherothrombosis. N Engl J Med. 1998 Apr 09; 338(15):1042-50. PMID: 9535670.
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  483. Upchurch GR, Leopold JA, Welch GN, Loscalzo J. Nitric Oxide Alters Human Microvascular Endothelial Cell Response to Cyclic Strain. J Cardiovasc Pharmacol Ther. 1998 Apr; 3(2):135-142. PMID: 10684491.
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  484. Liu Z, Rudd MA, Freedman JE, Loscalzo J. S-Transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide. J Pharmacol Exp Ther. 1998 Feb; 284(2):526-34. PMID: 9454793.
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  485. Eberhardt RT, Loscalzo J. Effect of cardiac drugs on platelet function. UpToDate. 1998; 6:1-10.
  486. Loscalzo J. Hemostasis and fibrinolysis. Thrombolysis Update. 1998; 1:1-3.
  487. Freedman J, Loscalzo J. Platelets and fibrinolysis/thrombosis. In: Fibrinolysis in Disease. Glas-Grenwalt P, editor. 1998.
  488. Leopold JA, Keaney JF, Loscalzo J. Pharmacology of thrombolytic agents. In: Thrombosis and Hemorrhage. Loscalzo J, Schafer AI, editors. 1998; 1215-58.
  489. Upchurch Jr , Ramdev N, Walsh MT, Loscalzo J. Prothrombotic Consequences of the Oxidation of Fibrinogen and their Inhibition by Aspirin. J Thromb Thrombolysis. 1998; 5(1):9-14. PMID: 10608044.
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  490. Welch GN, Upchurch GR, Loscalzo J. Fibrinolysis. In: Cardiac Intensive Care. Brown DL, editor. 1998; 83-90.
  491. Loscalzo J. Nitric oxide: biological and medical implications. In: Harrison's Principles of Internal Medicine. Fauci AS, Braunwald E, Isselbacher KJ, Wilson JD, Martin JB, Kasper DL, Hauser SL, Longo DL, editors. 1998; 442-4.
  492. Freedman JE, Scharfstein JS, Gold HK. New antithrombotic strategies. In: Thrombosis and Hemorrhage. Loscalzo J, Schafer AI, editors. 1998; 1259-77.
  493. Loscalzo J. The antithrombotic effects of nitric oxide. In: Vascular Endothelium: Pharmacologic and Genetic Manipulation. Catravas JD, Callow A, Ryan U, editors. 1998; 99-102.
  494. Cannon CP, Loscalzo J. Thrombolytic and antithrombotic therapies for acute coronary syndromes. In: Contemporary Concepts in Cardiology. Gorlin R, Toutouzas P, Dangas GD, Konstadoulakis MM, editors. 1998; 142-75.
  495. Dobroski DR, Rabbani LE, Loscalzo J. The relationship between thrombosis and atherosclerosis. In: Thrombosis and Hemorrhage. Loscalzo J, Schafer AI, editors. 1998; 837-61.
  496. Welch GN, Upchurch GR, Farivar RS, Pigazzi A, Vu K, Brecher P, Keaney JF, Loscalzo J. Homocysteine-induced nitric oxide production in vascular smooth-muscle cells by NF-kappa B-dependent transcriptional activation of Nos2. Proc Assoc Am Physicians. 1998 Jan-Feb; 110(1):22-31. PMID: 9460080.
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  497. Zhao Z, Francis CE, Welch G, Loscalzo J, Ravid K. Reduced glutathione prevents nitric oxide-induced apoptosis in vascular smooth muscle cells. Biochim Biophys Acta. 1997 Nov 27; 1359(2):143-52. PMID: 9409811.
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  498. Moraes D, Loscalzo J. Pulmonary hypertension: newer concepts in diagnosis and management. Clin Cardiol. 1997 Aug; 20(8):676-82. PMID: 9259160.
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  499. Kuo PC, Schroeder RA, Loscalzo J. Nitric oxide and acetaminophen-mediated oxidative injury: modulation of interleukin-1-induced nitric oxide synthesis in cultured rat hepatocytes. J Pharmacol Exp Ther. 1997 Aug; 282(2):1072-83. PMID: 9262377.
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  500. Upchurch GR, Welch GN, Fabian AJ, Pigazzi A, Keaney JF, Loscalzo J. Stimulation of endothelial nitric oxide production by homocyst(e)ine. Atherosclerosis. 1997 Jul 25; 132(2):177-85. PMID: 9242963.
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  501. Freedman JE, Loscalzo J, Barnard MR, Alpert C, Keaney JF, Michelson AD. Nitric oxide released from activated platelets inhibits platelet recruitment. J Clin Invest. 1997 Jul 15; 100(2):350-6. PMID: 9218511; PMCID: PMC508197.
  502. Upchurch GR, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF, Loscalzo J. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997 Jul 04; 272(27):17012-7. PMID: 9202015.
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  503. Welch GN, Upchurch GR, Loscalzo J. Homocysteine, oxidative stress, and vascular disease. Hosp Pract (1995). 1997 Jun 15; 32(6):81-2, 85, 88-92. PMID: 9194803.
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  504. Loscalzo J. Nitric oxide binding and the adverse effects of cell-free hemoglobins: what makes us different from earthworms. J Lab Clin Med. 1997 Jun; 129(6):580-3. PMID: 9178723.
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  505. Welch GN, Upchurch G, Loscalzo J. Hyperhomocyst(e)inemia and atherothrombosis. Ann N Y Acad Sci. 1997 Apr 15; 811:48-58; discussion 58-9. PMID: 9186584.
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  506. Upchurch GR, Welch GN, Freedman JE, Fabian AJ, Pigazzi A, Scribner AM, Alpert CS, Keaney JF, Loscalzo J. High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells. Circulation. 1997 Apr 15; 95(8):2115-21. PMID: 9133522.
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  507. Alpert C, Ramdev N, George D, Loscalzo J. Detection of S-nitrosothiols and other nitric oxide derivatives by photolysis-chemiluminescence spectrometry. Anal Biochem. 1997 Feb 01; 245(1):1-7. PMID: 9025962.
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  508. Sherman DL, Loscalzo J. Endothelial dysfunction and cardiovascular disease. Cardiologia. 1997 Feb; 42(2):177-87. PMID: 9090161.
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  509. Leopold JA, Loscalzo J. New developments in nitrosovasodilator therapy. Vasc Med. 1997; 2(3):190-202. PMID: 9546968.
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  510. Freedman JE, Loscalzo J. Endothelial dysfunction and atherothrombotic occlusive disease. Drugs. 1997; 54 Suppl 3:41-9; discussion 49-50. PMID: 9360851.
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  511. Loscalzo J, Schafer AI. Overview of hemostasis and fibrinolysis. In: New Therapeutic Agents in Thrombosis and Thrombolysis. Sasahara AA, Loscalzo J, editors. 1997; 1-7.
  512. Orlandi Q, Loscalzo J. Adhesion molecules in atherosclerosis. In: Adhesion Molecules in Health and Disease. Paul LC, Issekutz, TB, editors. 1997; 401-25.
  513. Loscalzo J. Section Editor. Vascular biology and physiology. In: Textbook of Coonary Thrombosis and Thrombolysis. Becker RC,editor. 1997.
  514. Upchurch GR, Loscalzo J, Banes AJ. Changes in the amplitude of cyclic load biphasically modulate endothelial cell DNA synthesis and division. Vasc Med. 1997; 2(1):19-24. PMID: 9546945.
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  515. Freedman JE, Loscalzo J. The role of platelets in coronary heart disease. UpToDate. 1997; 5:1-5.
  516. Loscalzo J. The Narrow Therapeutic Index of Thrombin Inhibition: Implications for Newer Antithrombotic Therapies. J Thromb Thrombolysis. 1997; 4(3/4):315-316. PMID: 10639632.
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  517. Ekery DL, Loscalzo J. Homocysteine and coronary atherosclerosis. Cardiol Gen Pract. 1997; 2:8-12.
  518. Robinson K, Loscalzo J. Other risk factors for coronary artery disease. In: Textbook of Cardiovascular Medicine. Topol EJ, editor. 1997; 231-47.
  519. Kuo PC, Slivka A, Loscalzo J. Nitric oxide regulates glutathione metabolism in hepatocyte oxidative stress. In: Immune Consequences of Trauma, Shock and Sepsis: Mechanisms and Therapeutic Approaches. Faist A, Baue AE, Schildberg FW. 1997; 667-72.
  520. Loscalzo J. Nitric oxide and hemostasis. In: Coronary Microcirculation during Ischaemia and Reperfusion. Haunso S, Aldershile J, Svendsen JH, editors. 1997; 142-50.
  521. Dobroski DR, Loscalzo J. Thrombotic risk factors for atherosclerosis. Coron Artery Dis. 1996 Dec; 7(12):919-32. PMID: 9116935.
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  522. Keaney JF, Hare JM, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Inhibition of nitric oxide synthase augments myocardial contractile responses to beta-adrenergic stimulation. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2646-52. PMID: 8997327.
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  523. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation. 1996 Nov 15; 94(10):2434-40. PMID: 8921785.
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  524. Michelson AD, Barnard MR, Hechtman HB, MacGregor H, Connolly RJ, Loscalzo J, Valeri CR. In vivo tracking of platelets: circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11877-82. PMID: 8876231; PMCID: PMC38152.
  525. Scharfstein JS, Abendschein DR, Eisenberg PR, George D, Cannon CP, Becker RC, Sobel B, Cupples LA, Braunwald E, Loscalzo J. Usefulness of fibrinogenolytic and procoagulant markers during thrombolytic therapy in predicting clinical outcomes in acute myocardial infarction. TIMI-5 Investigators. Thrombolysis in Myocardial Infarction. Am J Cardiol. 1996 Sep 01; 78(5):503-10. PMID: 8806332.
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  526. Jackson TS, Lerner E, Weisbrod RM, Tajima M, Loscalzo J, Keaney JF. Vasodilatory properties of recombinant maxadilan. Am J Physiol. 1996 Sep; 271(3 Pt 2):H924-30. PMID: 8853326.
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  527. Loscalzo J. Thrombin inhibitors in fibrinolysis. A Hobson's choice of alternatives. Circulation. 1996 Sep 01; 94(5):863-5. PMID: 8790015.
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  528. Upchurch GR, Valeri CR, Khuri SF, Rohrer MJ, Welch GN, MacGregor H, Ragno G, Francis S, Rodino LJ, Michelson AD, Loscalzo J. Effect of heparin on fibrinolytic activity and platelet function in vivo. Am J Physiol. 1996 Aug; 271(2 Pt 2):H528-34. PMID: 8770093.
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  529. Philippides GJ, Loscalzo J. Potential advantages of direct-acting thrombin inhibitors. Coron Artery Dis. 1996 Jul; 7(7):497-507. PMID: 8913677.
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  530. Loscalzo J. The oxidant stress of hyperhomocyst(e)inemia. J Clin Invest. 1996 Jul 01; 98(1):5-7. PMID: 8690803; PMCID: PMC507392.
  531. Zhang YY, Xu AM, Nomen M, Walsh M, Keaney JF, Loscalzo J. Nitrosation of tryptophan residue(s) in serum albumin and model dipeptides. Biochemical characterization and bioactivity. J Biol Chem. 1996 Jun 14; 271(24):14271-9. PMID: 8662958.
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  532. Michelson AD, Benoit SE, Furman MI, Breckwoldt WL, Rohrer MJ, Barnard MR, Loscalzo J. Effects of nitric oxide/EDRF on platelet surface glycoproteins. Am J Physiol. 1996 May; 270(5 Pt 2):H1640-8. PMID: 8928869.
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  533. Upchurch GR, Welch GN, Loscalzo J. Homocysteine, EDRF, and endothelial function. J Nutr. 1996 Apr; 126(4 Suppl):1290S-4S. PMID: 8642473.
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  534. Fuster V, Gotto AM, Libby P, Loscalzo J, McGill HC. 27th Bethesda Conference: matching the intensity of risk factor management with the hazard for coronary disease events. Task Force 1. Pathogenesis of coronary disease: the biologic role of risk factors. J Am Coll Cardiol. 1996 Apr; 27(5):964-76. PMID: 8609362.
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  535. Freedman JE, Loscalzo J, Benoit SE, Valeri CR, Barnard MR, Michelson AD. Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis. J Clin Invest. 1996 Feb 15; 97(4):979-87. PMID: 8613552; PMCID: PMC507144.
  536. Zhang Y, Loscalzo J. Nitrosation of proteins. Methods Neurosc. 1996; 31:41-6.
  537. Sherman DL, Upchurch GR, Loscalzo J. Alcohol and endothelial cell dysfunction. In: Alcohol and the Cardiovascular System. Zakhari S, Wassef M, editors. Bethesda: NIH. 1996; 567-89.
  538. Freedman JE, Loscalzo J. Arterial and venous thrombotic diseases: thrombolytic and antithrombotic therapies. In: Cardiovascular Therapeutics. Smith TW, editor. 1996; 470-81.
  539. Loscalzo J, Schafer AI. Anticoagulants, antiplatelet agents, and fibrinolytics. In: Vascular Medicine. Loscalzo J, Creager MA, Dzau VJ, editors. 1996; 639-64.
  540. Upchurch GR, Welch GN, Loscalzo J. The vascular biology of S-nitrosothiols, nitrosated derivatives of thiols. Vasc Med. 1996; 1(1):25-33. PMID: 9546910.
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  541. Loscalzo J, Radomski MW. Platelet bioassays of nitric oxide and related congeners. In: Methods in Nitric Oxide Research. Feelisch M, Stamler JS, editors. 1996; 584-91.
  542. Loscalzo J. Nitric oxide and restenosis. Clin Appl Thromb Hemost. 1996; 2:7-10.
  543. Vita JA, Keaney JF, Loscalzo J. Endothelial dysfunction in vascular disease. In: Vascular Medicine. Loscalzo J, Creager MA, Dzau VJ, editors. 1996; 245-64.
  544. Gokce N, Loscalzo J. Are newer antithrombotic drugs better than aspirin following angioplasty?. Cardiol Rev. 1996; 4:271-7.
  545. Stamler JS, Dzau VJ, Loscalzo J. The smooth muscle cell. In: Vascular Medicine. Loscalzo J, Creager MA, Dzau VJ, editors. 1996; 69-116.
  546. Vaughan DE, Schafer AI, Loscalzo J. Normal mechanisms of hemostasis and fibrinolysis. In: Vascular Medicine. Loscalzo J, Creager MA, Dzau VJ, editors. 1996; 207-16.
  547. Welch GN, Upchurch GR, Loscalzo J. Detection of S-nitrosothiols. Methods Neurosci. 1996; 31:34-40.
  548. Welch GN, Upchurch GR, Loscalzo J. S-nitrosothiol detection. Methods Enzymol. 1996; 268:293-8. PMID: 8782595.
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  549. Loscalzo J. The macrophage and fibrinolysis. Semin Thromb Hemost. 1996; 22(6):503-6. PMID: 9122715.
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  550. Khuri SF, Valeri CR, Loscalzo J, Michelson AD. Heparin effect on platelets and fibrinolysis - reply. Ann Thorac Surg. 1996; 61:1590-1.
  551. Marks DS, Vita JA, Folts JD, Keaney JF, Welch GN, Loscalzo J. Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide. J Clin Invest. 1995 Dec; 96(6):2630-8. PMID: 8675628; PMCID: PMC185968.
  552. Leopold JA, Loscalzo J. Platelet activation by fibrinolytic agents: a potential mechanism for resistance to thrombolysis and reocclusion after successful thrombolysis. Coron Artery Dis. 1995 Dec; 6(12):923-9. PMID: 8723013.
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  553. Levine GN, Chodos AP, Loscalzo J. Restenosis following coronary angioplasty: clinical presentations and therapeutic options. Clin Cardiol. 1995 Dec; 18(12):693-703. PMID: 8608668.
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  554. Khuri SF, Valeri CR, Loscalzo J, Weinstein MJ, Birjiniuk V, Healey NA, MacGregor H, Doursounian M, Zolkewitz MA. Heparin causes platelet dysfunction and induces fibrinolysis before cardiopulmonary bypass. Ann Thorac Surg. 1995 Oct; 60(4):1008-14. PMID: 7574939.
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  555. Nanji AA, Greenberg SS, Tahan SR, Fogt F, Loscalzo J, Sadrzadeh SM, Xie J, Stamler JS. Nitric oxide production in experimental alcoholic liver disease in the rat: role in protection from injury. Gastroenterology. 1995 Sep; 109(3):899-907. PMID: 7657120.
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  556. Loscalzo J, Welch G. Nitric oxide and its role in the cardiovascular system. Prog Cardiovasc Dis. 1995 Sep-Oct; 38(2):87-104. PMID: 7568906.
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  557. Zarich SW, Kowalchuk GJ, Weaver WD, Loscalzo J, Sassower M, Manzo K, Byrnes C, Muller JE, Gurewich V. Sequential combination thrombolytic therapy for acute myocardial infarction: results of the Pro-Urokinase and t-PA Enhancement of Thrombolysis (PATENT) Trial. J Am Coll Cardiol. 1995 Aug; 26(2):374-9. PMID: 7608437.
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  558. Simon DI, Stamler JS, Loh E, Loscalzo J, Francis SA, Creager MA. Effect of nitric oxide synthase inhibition on bleeding time in humans. J Cardiovasc Pharmacol. 1995 Aug; 26(2):339-42. PMID: 7475061.
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  559. Loscalzo J. Nitric oxide and vascular disease. N Engl J Med. 1995 Jul 27; 333(4):251-3. PMID: 7540723.
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  560. Schubert PJ, Loscalzo J. Antithrombotic therapy. Compr Ther. 1995 Jul; 21(7):344-50. PMID: 7554810.
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  561. Loscalzo J, Pasche B, Ouimet H, Freedman JE. Platelets and plasminogen activation. Thromb Haemost. 1995 Jul; 74(1):291-3. PMID: 8578474.
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  562. Freedman JE, Frei B, Welch GN, Loscalzo J. Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols. J Clin Invest. 1995 Jul; 96(1):394-400. PMID: 7615810; PMCID: PMC185212.
  563. Levy AP, Levy NS, Loscalzo J, Calderone A, Takahashi N, Yeo KT, Koren G, Colucci WS, Goldberg MA. Regulation of vascular endothelial growth factor in cardiac myocytes. Circ Res. 1995 May; 76(5):758-66. PMID: 7728992.
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  564. Freedman JE, Fabian A, Loscalzo J. Impaired EDRF production by endothelial cells exposed to fibrin monomer and FDP. Am J Physiol. 1995 Feb; 268(2 Pt 1):C520-6. PMID: 7532361.
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  565. Loscalzo J. Hyperlipoproteinemia. In: Gellis & Kagan's Current Pediatric Therapy. Burg FD, Ingelfinger JR, Wald ER, editors. 1995; 377-80.
  566. Upchurch GR, Welch GN, Loscalzo J. S-nitrosothiols: chemistry, biochemistry, and biological actions. Adv Pharmacol. 1995; 34:343-9. PMID: 8562444.
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  567. Hare JM, Keaney JF, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. J Clin Invest. 1995 Jan; 95(1):360-6. PMID: 7529262; PMCID: PMC295439.
  568. Loscalzo J. Fibrinolytic therapy. In: Williams Hematology. Beutler E, Lichtman MA, Coller BS, editors. 1995; 1585-91.
  569. Marks D, Loscalzo J. Vasoreactive disease: molecular approach. In: Molecular Interventions and Local Drug Delivery in Cardiovascular Diseases. Edelman ER, editor. 1995; 213-32.
  570. Vaughan DE, Passamani ER, Loscalzo J. Tissue-type plasminogen activator in acute myocardial infarction. In: Coronary Care. Alpert J, Francis G, editors. 1995; 443-50.
  571. Loscalzo J. Pathogenesis of thrombosis. In: Williams Hematology. Beutler E, Lichtman MA, Coller BS, editors. 1995; 1525-30.
  572. Lee LV. Initial experience with hirudin and streptokinase in acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 6 trial. Am J Cardiol. 1995 Jan 01; 75(1):7-13. PMID: 7801868.
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  573. Grevelink SA, Osborne J, Loscalzo J, Lerner EA. Vasorelaxant and second messenger effects of maxadilan. J Pharmacol Exp Ther. 1995 Jan; 272(1):33-7. PMID: 7815348.
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  574. Loscalzo J. Book Review: Prevention of venous thromboembolism, by D. Bergqvist. Circulation. 1995; 91:1896.
  575. Welch GN, Upchurch GR, Loscalzo J. Nitric oxide as a vascular modulator. Blood Rev. 1995; 9:262-9.
  576. Loscalzo J. Endothelial injury, vasoconstriction, and its prevention. Tex Heart Inst J. 1995; 22(2):180-4. PMID: 7647603; PMCID: PMC325239.
  577. Ezratty A, Freedman JE, Simon D, Loscalzo J. the antithrombotic effects of acetylation of fibrinogen by aspirin. J Vasc Med Biol. 1995; 5:152-9.
  578. Cannon CP, McCabe CH, Diver DJ, Herson S, Greene RM, Shah PK, Sequeira RF, Leya F, Kirshenbaum JM, Magorien RD, et al. Comparison of front-loaded recombinant tissue-type plasminogen activator, anistreplase and combination thrombolytic therapy for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 4 trial. J Am Coll Cardiol. 1994 Dec; 24(7):1602-10. PMID: 7963104.
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  579. Loh E, Stamler JS, Hare JM, Loscalzo J, Colucci WS. Cardiovascular effects of inhaled nitric oxide in patients with left ventricular dysfunction. Circulation. 1994 Dec; 90(6):2780-5. PMID: 7994821.
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  580. Loscalzo J, Vita JA. Ischemia, hyperemia, exercise, and nitric oxide. Complex physiology and complex molecular adaptations. Circulation. 1994 Nov; 90(5):2556-9. PMID: 7955218.
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  581. Slivka A, Chuttani R, Carr-Locke DL, Kobzik L, Bredt DS, Loscalzo J, Stamler JS. Inhibition of sphincter of Oddi function by the nitric oxide carrier S-nitroso-N-acetylcysteine in rabbits and humans. J Clin Invest. 1994 Nov; 94(5):1792-8. PMID: 7525649; PMCID: PMC294570.
  582. Scharfstein JS, Keaney JF, Slivka A, Welch GN, Vita JA, Stamler JS, Loscalzo J. In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. J Clin Invest. 1994 Oct; 94(4):1432-9. PMID: 7929818; PMCID: PMC295274.
  583. Flaker GC, Bartolozzi J, Davis V, McCabe C, Cannon CP. Use of a standardized heparin nomogram to achieve therapeutic anticoagulation after thrombolytic therapy in myocardial infarction. TIMI 4 investigators. Thrombolysis in Myocardial Infarction. Arch Intern Med. 1994 Jul 11; 154(13):1492-6. PMID: 8018004.
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  584. Keaney JF, Puyana JC, Francis S, Loscalzo JF, Stamler JS, Loscalzo J. Methylene blue reverses endotoxin-induced hypotension. Circ Res. 1994 Jun; 74(6):1121-5. PMID: 8187278.
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  585. Simon DI, Ezratty AM, Loscalzo J. The fibrin(ogen)olytic properties of cathepsin D. Biochemistry. 1994 May 31; 33(21):6555-63. PMID: 8204591.
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  586. Keaney JF, Shwaery GT, Xu A, Nicolosi RJ, Loscalzo J, Foxall TL, Vita JA. 17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Circulation. 1994 May; 89(5):2251-9. PMID: 8181150.
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  587. Welch G, Loscalzo J. Nitric oxide and the cardiovascular system. J Card Surg. 1994 May; 9(3):361-71. PMID: 8054733.
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  588. Cannon CP, McCabe CH, Henry TD, Schweiger MJ, Gibson RS, Mueller HS, Becker RC, Kleiman NS, Haugland JM, Anderson JL, et al. A pilot trial of recombinant desulfatohirudin compared with heparin in conjunction with tissue-type plasminogen activator and aspirin for acute myocardial infarction: results of the Thrombolysis in Myocardial Infarction (TIMI) 5 trial. J Am Coll Cardiol. 1994 Apr; 23(5):993-1003. PMID: 8144799.
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  589. Ouimet H, Freedman JE, Loscalzo J. Kinetics and mechanism of platelet-surface plasminogen activation by tissue-type plasminogen activator. Biochemistry. 1994 Mar 15; 33(10):2970-6. PMID: 8130211.
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  590. Rabbani LE, Edelman ER, Ganz P, Selwyn AP, Loscalzo J, Bittl JA. Relation of restenosis after excimer laser angioplasty to fasting insulin levels. Am J Cardiol. 1994 Feb 15; 73(5):323-7. PMID: 8109544.
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  591. Gaston B, Drazen JM, Jansen A, Sugarbaker DA, Loscalzo J, Richards W, Stamler JS. Relaxation of human bronchial smooth muscle by S-nitrosothiols in vitro. J Pharmacol Exp Ther. 1994 Feb; 268(2):978-84. PMID: 7906736.
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  592. Keaney JF, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA. Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. J Clin Invest. 1994 Feb; 93(2):844-51. PMID: 8113416; PMCID: PMC293946.
  593. Gaston B, Drazen JM, Loscalzo J, Stamler JS. The biology of nitrogen oxides in the airways. Am J Respir Crit Care Med. 1994 Feb; 149(2 Pt 1):538-51. PMID: 7508323.
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  594. Pasche B, Ouimet H, Francis S, Loscalzo J. Structural changes in platelet glycoprotein IIb/IIIa by plasmin: determinants and functional consequences. Blood. 1994 Jan 15; 83(2):404-14. PMID: 8286740.
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  595. Schaub RG, Bree MP, Hayes LL, Rudd MA, Rabbani L, Loscalzo J, Clinton SK. Recombinant human macrophage colony-stimulating factor reduces plasma cholesterol and carrageenan granuloma foam cell formation in Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb. 1994 Jan; 14(1):70-6. PMID: 8274480.
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  596. Michelson AD, Barnard MR, Valeri CR, Khuri SF, Loscalzo J. Platelet aggregation abnormalities after cardiopulmnary bypass. Blood. 1994; 83:300-1.
  597. Gaston B, Drazen JM, Lilly C, Sugarbaker DA, Loscalzo J, Stamler JS. Bioactive oxides of nitrogen in the lung: immunity and the neural axis. In: Nitric Oxide: Brain and Immune System. Moncada S, Nistico S, Tubbs EA, editors. 1994; 265-76.
  598. Burchenal JE, Loscalzo J. Endothelial dysfunction and pulmonary hypertension. Prim Cardiol. 1994; 20:28-32.
  599. Rabbani LE, Loscalzo J. Recent observations on the role of hemostatic determinants in the development of the atherothrombotic plaque. Atherosclerosis. 1994 Jan; 105(1):1-7. PMID: 8155083.
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  600. Jaraki O, Strauss WE, Francis S, Loscalzo J, Stamler JS. Antiplatelet effects of a novel antianginal agent, nicorandil. J Cardiovasc Pharmacol. 1994 Jan; 23(1):24-30. PMID: 7511731.
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  601. Keaney JF, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA. Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11880-4. PMID: 8265642; PMCID: PMC48088.
  602. Sharma GV, Lapsley D, Vita JA, Sharma S, Coccio E, Adelman B, Loscalzo J. Usefulness and tolerability of hirulog, a direct thrombin-inhibitor, in unstable angina pectoris. Am J Cardiol. 1993 Dec 15; 72(18):1357-60. PMID: 8256726.
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  603. Rachmilewitz D, Stamler JS, Karmeli F, Mullins ME, Singel DJ, Loscalzo J, Xavier RJ, Podolsky DK. Peroxynitrite-induced rat colitis--a new model of colonic inflammation. Gastroenterology. 1993 Dec; 105(6):1681-8. PMID: 8253344.
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  604. Gaston B, Reilly J, Drazen JM, Fackler J, Ramdev P, Arnelle D, Mullins ME, Sugarbaker DJ, Chee C, Singel DJ, et al. Endogenous nitrogen oxides and bronchodilator S-nitrosothiols in human airways. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):10957-61. PMID: 8248198; PMCID: PMC47900.
  605. Simon DI, Ezratty AM, Francis SA, Rennke H, Loscalzo J. Fibrin(ogen) is internalized and degraded by activated human monocytoid cells via Mac-1 (CD11b/CD18): a nonplasmin fibrinolytic pathway. Blood. 1993 Oct 15; 82(8):2414-22. PMID: 8400291.
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  606. Rabbani LE, Loscalzo J. Atherothrombotic insights into secondary prevention after acute myocardial infarction. Can J Cardiol. 1993 Oct; 9(8):739-47. PMID: 7903593.
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  607. Grevelink SA, Youssef DE, Loscalzo J, Lerner EA. Salivary gland extracts from the deerfly contain a potent inhibitor of platelet aggregation. Proc Natl Acad Sci U S A. 1993 Oct 01; 90(19):9155-8. PMID: 8415671; PMCID: PMC47520.
  608. Lilly CM, Stamler JS, Gaston B, Meckel C, Loscalzo J, Drazen JM. Modulation of vasoactive intestinal peptide pulmonary relaxation by NO in tracheally superfused guinea pig lungs. Am J Physiol. 1993 Oct; 265(4 Pt 1):L410-5. PMID: 8238376.
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  609. Rovin JD, Stamler JS, Loscalzo J, Folts JD. Sodium nitroprusside, an endothelium-derived relaxing factor congener, increases platelet cyclic GMP levels and inhibits epinephrine-exacerbated in vivo platelet thrombus formation in stenosed canine coronary arteries. J Cardiovasc Pharmacol. 1993 Oct; 22(4):626-31. PMID: 7505366.
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  610. Lipton SA, Choi YB, Pan ZH, Lei SZ, Chen HS, Sucher NJ, Loscalzo J, Singel DJ, Stamler JS. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature. 1993 Aug 12; 364(6438):626-32. PMID: 8394509.
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  611. Loscalzo J. The induction of cellular interactions in atherogenesis and their modulation. Biochem Soc Trans. 1993 Aug; 21 ( Pt 3)(3):656-9. PMID: 8135929.
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  612. Kestin AS, Valeri CR, Khuri SF, Loscalzo J, Ellis PA, MacGregor H, Birjiniuk V, Ouimet H, Pasche B, Nelson MJ, et al. The platelet function defect of cardiopulmonary bypass. Blood. 1993 Jul 01; 82(1):107-17. PMID: 7686785.
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  613. Rabbani LE, Johnstone MT, Rudd MA, Devine P, George D, Loscalzo J. PPACK attenuates plasmin-induced changes in endothelial integrity. Thromb Res. 1993 Jun 15; 70(6):425-36. PMID: 8362368.
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  614. Ouimet H, Loscalzo J. Reciprocating autocatalytic interactions between platelets and the activation system. Thromb Res. 1993 Jun 01; 70(5):355-64. PMID: 8397449.
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  615. Simon DI, Stamler JS, Jaraki O, Keaney JF, Osborne JA, Francis SA, Singel DJ, Loscalzo J. Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. Arterioscler Thromb. 1993 Jun; 13(6):791-9. PMID: 8388713.
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  616. Ezratty A, Simon DI, Loscalzo J. Lipoprotein(a) binds to human platelets and attenuates plasminogen binding and activation. Biochemistry. 1993 May 04; 32(17):4628-33. PMID: 8485140.
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  617. Keaney JF, Simon DI, Stamler JS, Jaraki O, Scharfstein J, Vita JA, Loscalzo J. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. J Clin Invest. 1993 Apr; 91(4):1582-9. PMID: 8473501; PMCID: PMC288134.
  618. Cannon CP, Maraganore JM, Loscalzo J, McAllister A, Eddings K, George D, Selwyn AP, Adelman B, Fox I, Braunwald E, et al. Anticoagulant effects of hirulog, a novel thrombin inhibitor, in patients with coronary artery disease. Am J Cardiol. 1993 Apr 01; 71(10):778-82. PMID: 8456753.
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  619. Stamler JS, Osborne JA, Jaraki O, Rabbani LE, Mullins M, Singel D, Loscalzo J. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen. J Clin Invest. 1993 Jan; 91(1):308-18. PMID: 8380812; PMCID: PMC330028.
  620. Mendelsohn ME, Loscalzo J. The endotheliopathies: endothelial dysfunction in clinical disorders. In: Thrombosis and Hemorrhage. Loscalzo J, Schafer AI, editors. 1993; 861-82.
  621. Keaney JF, Loscalzo J. Pharmacology of thrombolytic agents. In: Thrombosis and Hemorrhage. Loscalzo J, Schafer AI, editors. 1993; 1173-1206.
  622. Ouimet H, Loscalzo J. Fibrinolysis. In: Thrombosis and Hemorrhage. Loscalzo J, Schafer AI, editors. 1993; 127-44.
  623. Fernadopulle R, Loscalzo J. Atherosclerosis. In: Pathophysiology of Heart Disease. 1993; 84-97.
  624. Simon DI, Ezratty AM, Loscalzo J. Lipoprotein(a) and atherothrombosis. Curr Opin Cardiol. 1993; 8:814-20.
  625. Loscalo J, Sniderman A. Cardiovascular disease and hyperlipidaemia: editorial overview. Curr Opin Lipidol. 1993; 4:273-6.
  626. Scharfstein JS, Gold HK, Loscalzo J. New antithrombotic strategies. In: Thrombosis and Hemorrhage. Loscalzo J, Schafer AI, editors. 1993; 1207-24.
  627. Rabbani LE, Loscalzo J. The relationship between atherosclerosis and thrombosis. In: Thrombosis and Hemorrhage. Loscalzo J, Schafer AI, editors. 1993; 769-90.
  628. Loscalzo J. Thrombotic determinants of macrophage foam-cell formation. Atherosclerosis Rev. 1993; 23:39-47.
  629. Loscalzo J. Hyperlipoproteinemia. In: Current Pediatric Therapy 14. Burg FD, Ingelfinger JR, Wald ER, editors. 1993; 331-3.
  630. Kuo PC, Slivka A, Wilmore D, Loscalzo J. Exogenous delivery of nitric oxide: a novel treatment for toxin-mediated hepatocyte injury. Surg Forum. 1993; 44:53-5.
  631. Stamler JS, Singel DJ, Loscalzo J. Biochemistry of nitric oxide and its redox-activated forms. Science. 1992 Dec 18; 258(5090):1898-902. PMID: 1281928.
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  632. McIntyre KM, Vita JA, Lambrew CT, Freeman J, Loscalzo J. A noninvasive method of predicting pulmonary-capillary wedge pressure. N Engl J Med. 1992 Dec 10; 327(24):1715-20. PMID: 1435916.
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  633. Loscalzo J. The relation between atherosclerosis and thrombosis. Circulation. 1992 Dec; 86(6 Suppl):III95-9. PMID: 1424055.
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  634. Winther K, Hillegass W, Tofler GH, Jimenez A, Brezinski DA, Schafer AI, Loscalzo J, Williams GH, Muller JE. Effects on platelet aggregation and fibrinolytic activity during upright posture and exercise in healthy men. Am J Cardiol. 1992 Oct 15; 70(11):1051-5. PMID: 1414903.
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  635. Loscalzo J. Antiplatelet and antithrombotic effects of organic nitrates. Am J Cardiol. 1992 Sep 24; 70(8):18B-22B. PMID: 1529922.
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  636. Yusuf S, Pitt B, Davis CE, Hood WB, Cohn JN. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N Engl J Med. 1992 09 03; 327(10):685-91. PMID: 1463530.
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  637. Stamler JS, Simon DI, Jaraki O, Osborne JA, Francis S, Mullins M, Singel D, Loscalzo J. S-nitrosylation of tissue-type plasminogen activator confers vasodilatory and antiplatelet properties on the enzyme. Proc Natl Acad Sci U S A. 1992 Sep 01; 89(17):8087-91. PMID: 1325644; PMCID: PMC49861.
  638. Seed M, Loscalzo J. Lipoprotein(a) and coronary heart disease. BMJ. 1992 Aug 22; 305(6851):472-3. PMID: 1392966; PMCID: PMC1882530.
  639. Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel D, Valeri CR, Loscalzo J. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7674-7. PMID: 1502182; PMCID: PMC49773.
  640. Loscalzo J. Endothelial dysfunction in pulmonary hypertension. N Engl J Med. 1992 Jul 09; 327(2):117-9. PMID: 1603118.
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  641. Scharfstein J, Loscalzo J. Molecular approaches to antithrombotic therapy. Hosp Pract (Off Ed). 1992 May 15; 27(5):77-86. PMID: 1577892.
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  642. Stamler JS, Loscalzo J. Capillary zone electrophoretic detection of biological thiols and their S-nitrosated derivatives. Anal Chem. 1992 Apr 01; 64(7):779-85. PMID: 1524223.
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  643. Jansen A, Drazen J, Osborne JA, Brown R, Loscalzo J, Stamler JS. The relaxant properties in guinea pig airways of S-nitrosothiols. J Pharmacol Exp Ther. 1992 Apr; 261(1):154-60. PMID: 1560360.
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  644. Rudd MA, George D, Johnstone MT, Moore RT, Collins L, Rabbani LE, Loscalzo J. Effect of thrombin inhibition on the dynamics of thrombolysis and on platelet function during thrombolytic therapy. Circ Res. 1992 Apr; 70(4):829-34. PMID: 1551206.
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  645. Vaughan DE, Schafer AI, Loscalzo J. Normal mechanisms of hemostasis and fibrinolysis. In: Vascular Medicine. Loscalzo J, Creager MA, Dzau VJ, editors. 1992; 233-47.
  646. Stamler JS, Dzau VJ, Loscalzo J. The smooth muscle cell. In: Vascular Medicine. Loscalzo J, Creager MA, Dzau VJ, editors. 1992; 79-132.
  647. Loscalzo J, Rocco TP. Imaging arterial thrombi. An elusive goal. Circulation. 1992 Jan; 85(1):382-5. PMID: 1728477.
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  648. Stamler JS, Loscalzo J. Endothelium-derived relaxing factor modulates the atherothrombogenic effects of homocysteine. J Cardiovasc Pharmacol. 1992; 20 Suppl 12:S202-4. PMID: 1282970.
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  649. Loscalzo J, Handin RI. Platelet glycocalicin. Methods Enzymol. 1992; 215:289-94. PMID: 1435328.
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  650. Simon DI, Loscalzo J. Lipoprotein(a): a unique atherothrombotic risk factor. Choices Cardiol. 1992; 6:7-9.
  651. Mullins ME, Stamler JS, Osborne JA, Loscalzo J, Singel DJ. EPR spectroscopic characterization of biological thiyl radicals as PBN spin-trap adducts. Appl Magnet Reson. 1992; 3:1021-32.
  652. Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):444-8. PMID: 1346070; PMCID: PMC48254.
  653. Loscalzo J. Lipoprotein(a): a lipoprotein particle central to the interface of atherosclerosis and thrombosis. Arteriosclerosis. 1992; 9:143-6.
  654. Loscalzo J. Thrombotic mechanisms in atherogenesis. In: Mechanisms of Coronary Disease. Part I: Development of Atherosclerosis and Thrombosis. Pitt B, editor. 1992; 23-7.
  655. Loscalzo J, Ezratty A. Newer antiplatelet agents in acute myocardial infarction. In: Adjunctive Therapy for Acute Myocardial Infarction. Bates E, editor. 1992; 199-220.
  656. Ezratty A, Loscalzo J. Lipoprotein(a): a risk factor with novel mechanisms for the development of atherothrombotic disease. Adv Endocrinol Metab. 1992; 3:237-56.
  657. Loscalzo J, Schafer AI. Anticoagulants, antiplatelet agents, and fibrinolytics. In: Vascular Medicine. Loscalzo J, Creager MA, Dzau VJ, editors. 1992; 659-82.
  658. Loscalzo J. Newest risk factor for atherosclerosis: lipoprotein(a). Cortland Forum. 1992; 5:66-7.
  659. Mendelsohn ME, Loscalzo J. The endotheliopathies. In: Vascular Medicine. Loscalzo J, Creager MA, Dzau VJ, editors. 1992; 279-305.
  660. Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J. Exposure of sulphydryl-containing proteins to nitric oxide and endothelium-derived relaxing factor confers novel bioactivity and modulates their intrinsic functional properties. In: The Biology of Nitric Oxide. Moncada S, Marletta MA, Hibbs JB, Higgs EA, editors. 1992; 20-3.
  661. Bilheimer D, Loscalzo J. Cardiovascular diseae: hyperlipidaemia and coagulation. Editorial overview. Curr Opin Lipidol. 1992; 3:253-6.
  662. Kirshenbaum JM, Bahr RD, Flaherty JT, Gurewich V, Levine HJ, Loscalzo J, Schumacher RR, Topol EJ, Wahr DW, Braunwald E. Clot-selective coronary thrombolysis with low-dose synergistic combinations of single-chain urokinase-type plasminogen activator and recombinant tissue-type plasminogen activator. The Pro-Urokinase for Myocardial Infarction Study Group. Am J Cardiol. 1991 Dec 15; 68(17):1564-9. PMID: 1746455.
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  663. Rudd MA, Johnstone MT, Rabbani LE, George D, Ware JA, Loscalzo J. Thrombolytic therapy causes an increase in vascular permeability that is reversed by 1-deamino-8-D-vasopressin. Circulation. 1991 Dec; 84(6):2568-73. PMID: 1835680.
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  664. Stamler JS, Loscalzo J. The antiplatelet effects of organic nitrates and related nitroso compounds in vitro and in vivo and their relevance to cardiovascular disorders. J Am Coll Cardiol. 1991 Nov 15; 18(6):1529-36. PMID: 1939957.
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  665. Cooke JP, Rossitch E, Andon NA, Loscalzo J, Dzau VJ. Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. J Clin Invest. 1991 Nov; 88(5):1663-71. PMID: 1719029; PMCID: PMC295698.
  666. Newburger JW, Burns JC, Beiser AS, Loscalzo J. Altered lipid profile after Kawasaki syndrome. Circulation. 1991 Aug; 84(2):625-31. PMID: 1860206.
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  667. Yusuf S, Pitt B, Davis CE, Hood WB, Cohn JN. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med. 1991 08 01; 325(5):293-302. PMID: 2057034.
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  668. Stamler JS, Vaughan DE, Loscalzo J. Immunosuppressive therapy and lipoprotein abnormalities after cardiac transplantation. Am J Cardiol. 1991 Aug 01; 68(4):389-91. PMID: 1858681.
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  669. Simon DI, Fless GM, Scanu AM, Loscalzo J. Tissue-type plasminogen activator binds to and is inhibited by surface-bound lipoprotein(a) and low-density lipoprotein. Biochemistry. 1991 Jul 09; 30(27):6671-7. PMID: 1829635.
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  670. Ezratty AM, Loscalzo J. New approaches to antiplatelet therapy. Blood Coagul Fibrinolysis. 1991 Apr; 2(2):317-27. PMID: 1893063.
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  671. Shaffer JE, Lee F, Thomson S, Han BJ, Cooke JP, Loscalzo J. The hemodynamic effects of S-nitrosocaptopril in anesthetized dogs. J Pharmacol Exp Ther. 1991 Feb; 256(2):704-9. PMID: 1899703.
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  672. Simon D, Loscalzo J. Lipoprotein(a): a unique cardiovascular risk factor. Cardiovasc Risk. 1991; 1:174-8.
  673. Loscalzo J. L'azione della lipoprotein(a) sulla fibrinolisi. G Arteriosclerosi. 1991; 16:29-30.
  674. Folts JD, Stamler J, Loscalzo J. Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries. Circulation. 1991; 83(6):2122-7.
  675. Pasche B, Loscalzo J. Platelets and fibrinolysis. Platelets. 1991; 2:125-34.
  676. Stamler JS, Loscalzo J. Antithrombotic effects of organic nitrates in cardiovascular disease. Trends Cardiovasc Med. 1991; 1:346-53.
  677. Loscalzo J. The atherosclerotic process. Prim Care Newsl. 1991; 2:7-10.
  678. Loscalzo J, Braunwald E. Atherosclerosis. In: Video Textbook of Medicine. Braunwald E, editor. 1991.
  679. Loscalzo J. Lipoprotein(a): a risk factor for atherothrombotic disease. In: Heart Disease: Clinical Update. Braunwald E, editor. 1991; 10-7.
  680. Vaughan DE, Loscalzo J. New directions in thrombolytic therapy. Molecular mutants and biochemical conjugates. Trends Cardiovasc Med. 1991; 36-9.
  681. Handin RI, Loscalzo J. Hemostasis, thrombosis, fibrinolysis, and cardiovascular disease. In: Heart Disease. Braunwald E, editor. 1991; 1767-89.
  682. Rabbani LE, Loscalzo J. The effects of hyperlipidemia and atherosclerosis on endothelial function and vascular reactivity. Curr Opin Lipidol. 1991; 2:259-65.
  683. Nicolosi RJ, Stucchi AF, Loscalzo J. Effect of dietary fat saturation on low density lipoprotein metabolism. In: Heath Effects of Dietary Fatty Acids. Nelson GJ, editor. 1991; 77-82.
  684. Johnstone MT, Andrews T, Ware JA, Rudd MA, George D, Weinstein M, Loscalzo J. Bleeding time prolongation with streptokinase and its reduction with 1-desamino-8-D-arginine vasopressin. Circulation. 1990 Dec; 82(6):2142-51. PMID: 2242538.
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  685. Loscalzo J. Regression of coronary atherosclerosis. N Engl J Med. 1990 Nov 08; 323(19):1337-9. PMID: 2215620.
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  686. Mendelsohn ME, O'Neill S, George D, Loscalzo J. Inhibition of fibrinogen binding to human platelets by S-nitroso-N-acetylcysteine. J Biol Chem. 1990 Nov 05; 265(31):19028-34. PMID: 2172242.
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  687. Rudd MA, George D, Amarante P, Vaughan DE, Loscalzo J. Temporal effects of thrombolytic agents on platelet function in vivo and their modulation by prostaglandins. Circ Res. 1990 Nov; 67(5):1175-81. PMID: 2146037.
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  688. Cooke JP, Stamler J, Andon N, Davies PF, McKinley G, Loscalzo J. Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol. Am J Physiol. 1990 Sep; 259(3 Pt 2):H804-12. PMID: 2396689.
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  689. Loscalzo J. Molecular biologic modification of plasminogen activators. An artful science. Circulation. 1990 Sep; 82(3):1062-3. PMID: 2118430.
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  690. Loscalzo J. Lipoprotein(a). A unique risk factor for atherothrombotic disease. Arteriosclerosis. 1990 Sep-Oct; 10(5):672-9. PMID: 2144959.
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  691. Kuo P, Weinfeld M, Loscalzo J. Effect of membrane fatty acyl composition on LDL metabolism in Hep G2 hepatocytes. Biochemistry. 1990 Jul 17; 29(28):6626-32. PMID: 2168736.
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  692. Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, Dzau VJ. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest. 1990 Jul; 86(1):228-34. PMID: 2195060; PMCID: PMC296711.
  693. Loscalzo J. An overview of thrombolytic agents. Chest. 1990 Apr; 97(4 Suppl):117S-123S. PMID: 2182306.
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  694. Loscalzo J, Weinfeld M, Fless GM, Scanu AM. Lipoprotein(a), fibrin binding, and plasminogen activation. Arteriosclerosis. 1990 Mar-Apr; 10(2):240-5. PMID: 2138452.
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  695. Jenkins JL, Loscalzo J. Emergency Medicine-Essentials of Differential Diagnosis and Therapeutics, 2nd Edition. 1990.
  696. Loscalzo J, Fless GM, Scanu AM. Lp(a) and the fibrinolytic system. In: Lipoprotein(a). Scanu AM, editor. 1990; 103-15.
  697. Cooke JP, Stamler J, Andon NA, Davies PF, Mendelsohn ME, Loscalzo J. Flow-mediated endothelium-dependent effects on platelet and vascular reactivity. In: Endothelium-derived Vasoactive Factors. Rubanyi GM, Vanhoutte PM, editors. 1990; 1-10.
  698. Mendelsohn ME, Loscalzo J. Sudden cardiac death. N Engl J Med. 1990; 322:271-2.
  699. Loscalzo J. Current issues in thrombolytic therapy for acute myocardial infarction. J Myocard Ischemia. 1990; 1:48-57.
  700. Kuo P, Weinfeld M, Rudd MA, Amarante P, Loscalzo J. Plasma membrane enrichment with cis-unsaturated fatty acids enhances LDL metabolism in U937 monocytes. Arteriosclerosis. 1990 Jan-Feb; 10(1):111-8. PMID: 2297341.
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  701. Simon DI, Loscalzo J. Lipoprotein(a) and coronary heart disease in patients with familial hypercholesterolemia. N Engl J Med. 1990; 323:1773-4..
  702. Kuo PC, Rudd MA, Nicolosi R, Loscalzo J. Effect of dietary fat saturation and cholesterol on low density lipoprotein degradation by mononuclear cells of Cebus monkeys. Arteriosclerosis. 1989 Nov-Dec; 9(6):919-27. PMID: 2590069.
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  703. Inbal A, Loscalzo J. Glycocalicin binding to von Willebrand factor adsorbed onto collagen-coated or polystyrene surfaces. Thromb Res. 1989 Nov 01; 56(3):347-57. PMID: 2617474.
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  704. Vaughan DE, Mendelsohn ME, Declerck PJ, Van Houtte E, Collen D, Loscalzo J. Characterization of the binding of human tissue-type plasminogen activator to platelets. J Biol Chem. 1989 Sep 25; 264(27):15869-74. PMID: 2550424.
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  705. Stamler JS, Vaughan DE, Loscalzo J. Synergistic disaggregation of platelets by tissue-type plasminogen activator, prostaglandin E1, and nitroglycerin. Circ Res. 1989 Sep; 65(3):796-804. PMID: 2504509.
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  706. Stamler J, Mendelsohn ME, Amarante P, Smick D, Andon N, Davies PF, Cooke JP, Loscalzo J. N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ Res. 1989 Sep; 65(3):789-95. PMID: 2548765.
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  707. Schafer AI, Rodriguez R, Loscalzo J, Gimbrone MA. Inhibition of vascular endothelial cell prostacyclin synthesis by plasmin. Blood. 1989 Aug 15; 74(3):1015-20. PMID: 2526669.
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  708. Loscalzo J, Smick D, Andon N, Cooke J. S-nitrosocaptopril. I. Molecular characterization and effects on the vasculature and on platelets. J Pharmacol Exp Ther. 1989 Jun; 249(3):726-9. PMID: 2659776.
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  709. Cooke JP, Andon N, Loscalzo J. S-nitrosocaptopril. II. Effects on vascular reactivity. J Pharmacol Exp Ther. 1989 Jun; 249(3):730-4. PMID: 2659777.
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  710. Loscalzo J, Wharton TP, Kirshenbaum JM, Levine HJ, Flaherty JT, Topol EJ, Ramaswamy K, Kosowsky BD, Salem DN, Ganz P, et al. Clot-selective coronary thrombolysis with pro-urokinase. Circulation. 1989 Apr; 79(4):776-82. PMID: 2494004.
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  711. Vaughan DE, Plavin SR, Schafer AI, Loscalzo J. PGE1 accelerates thrombolysis by tissue plasminogen activator. Blood. 1989 Apr; 73(5):1213-7. PMID: 2495035.
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  712. Loscalzo J. Thrombolysis in the management of acute myocardial infarction and unstable angina pectoris. Drugs. 1989 Feb; 37(2):191-204. PMID: 2649355.
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  713. Stamler J, Whittemore AD, Loscalzo J. Celiac axis compression syndrome caused by sarcoidosis: an acquired form of the syndrome. Am J Med. 1989 Feb; 86(2):225-7. PMID: 2913788.
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  714. Sacks FM, Creager MA, Gallagher SJ, Loscalzo J, Dzau VJ. Effects of alpha- and beta-adrenergic antagonists on plasma apolipoproteins and forearm blood flow in patients with mild hypertension. Am J Med. 1989 Jan 23; 86(1B):8-13. PMID: 2563311.
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  715. Loscalzo J, Amarante P. Enhancement of tissue-type plasminogen activator activity by poly-L-lysine. J Vasc Med Biol. 1989; 1:336-40.
  716. Johnstone M, Loscalzo J. Bleeding with thrombolytic therapy in acute MI. Cardio Sept. 1989; 41-4, 132.
  717. Mendelsohn ME, Loscalzo J. Low-density lipoprotein and atherogenesis. N Engl J Med. 1989; 321:1196.
  718. Vaughan DE, Loscalzo J. Comparative effects of plasminogen activators on platelet disaggregation. J Vasc Med Biol. 1989; 1:27-31..
  719. Loscalzo J. Relations between thrombolysis and dietary fiber. In: Proceedings of the Scientific Conference on the Effects of Dietary Fatty Acids on Serum Lipoproteins and Hemostasis, Washington, D.C., May 23-24, 1989. American Heart Association. 1989; 161-7.
  720. Loscalzo J. Platelets and thrombolysis. J Vasc Med Biol. 1989; 1:213-9.
  721. Tang SS, Loscalzo J, Dzau VJ. Tissue plasminogen activator activates the renin-angiotensin system in vitro. J Vasc Med Biol. 1989; 2(1):67-74.
  722. Goldhaber SZ, Kessler CM, Heit J, Markis JE, Sharma GV, Dawley DL, Meyerovitz MF, Vaughan DE, Parker JA, Come PC, et al. Tissue plasminogen activator and acute pulmonary embolism. J Cell Biochem. 1988 Dec; 38(4):303-12. PMID: 3149283.
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  723. Stamler JS, Vaughan DE, Rudd MA, Mudge GH, Kirshenbaum J, Young P, Alexander RW, Loscalzo J. Frequency of hypercholesterolemia after cardiac transplantation. Am J Cardiol. 1988 Dec 01; 62(17):1268-72. PMID: 3057854.
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  724. Stamler JS, Creager MA, Loscalzo J, Cooke JP. Vascular response in diabetes with neuropathic foot lesions. N Engl J Med. 1988 Oct 27; 319(17):1155. PMID: 3173448.
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  725. Goldhaber SZ, Loscalzo J. Urokinase versus tissue plasminogen activator in pulmonary embolism. Lancet. 1988 Oct 15; 2(8616):915. PMID: 2902375.
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  726. Loscalzo J, Braunwald E. Tissue plasminogen activator. N Engl J Med. 1988 Oct 06; 319(14):925-31. PMID: 3138537.
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  727. Loscalzo J. Structural and kinetic comparison of recombinant human single- and two-chain tissue plasminogen activator. J Clin Invest. 1988 Oct; 82(4):1391-7. PMID: 3139714; PMCID: PMC442696.
  728. Stamler J, Cunningham M, Loscalzo J. Reduced thiols and the effect of intravenous nitroglycerin on platelet aggregation. Am J Cardiol. 1988 Sep 01; 62(7):377-80. PMID: 3137795.
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  729. Goldhaber SZ, Kessler CM, Heit J, Markis J, Sharma GV, Dawley D, Nagel JS, Meyerovitz M, Kim D, Vaughan DE, et al. Randomised controlled trial of recombinant tissue plasminogen activator versus urokinase in the treatment of acute pulmonary embolism. Lancet. 1988 Aug 06; 2(8606):293-8. PMID: 2899718.
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  730. Goldhaber SZ, Vaughan DE, Tumeh SS, Loscalzo J. Utility of cross-linked fibrin degradation products in the diagnosis of pulmonary embolism. Am Heart J. 1988 Aug; 116(2 Pt 1):505-8. PMID: 3400569.
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  731. Vaughan DE, Kirshenbaum JM, Loscalzo J. Streptokinase-induced, antibody-mediated platelet aggregation: a potential cause of clot propagation in vivo. J Am Coll Cardiol. 1988 Jun; 11(6):1343-8. PMID: 3130418.
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  732. Mendelsohn ME, Loscalzo J. Role of platelets in cholesteryl ester formation by U-937 cells. J Clin Invest. 1988 Jan; 81(1):62-8. PMID: 3335643; PMCID: PMC442473.
  733. Loscalzo J, Vaughan DE. Treatment of disorders of cholesterol metabolism. Med Update. 1988; 1:1-5.
  734. Loscalzo J. Disorders of lipid metabolism. In: Intensive Review of Internal Medicine. Fanta C, Braunwald E, editors. 1988; 334-343.
  735. Loscalzo J. Thrombolytic therapy in acute myocardial infarction. Med Update. 1988; 1:1-5.
  736. Loscalzo J. When are antiplatelet agents likely to be most effective in treating cardiovascular disease?. Choices Cardiol. 1988; 2:81-3.
  737. Goldhaber SZ, Meyerovitz MF, Markis JE, Kim D, Kessler CM, Sharma GV, Vaughan DE, Selwyn AP, Dawley DL, Loscalzo J, et al. Thrombolytic therapy of acute pulmonary embolism: current status and future potential. J Am Coll Cardiol. 1987 Nov; 10(5 Suppl B):96B-104B. PMID: 3117862.
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  738. Loscalzo J, Freedman J, Rudd MA, Barsky-Vasserman I, Vaughan DE. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. Arteriosclerosis. 1987 Sep-Oct; 7(5):450-5. PMID: 3675304.
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  739. Vaughan DE, Goldhaber SZ, Kim J, Loscalzo J. Recombinant tissue plasminogen activator in patients with pulmonary embolism: correlation of fibrinolytic specificity and efficacy. Circulation. 1987 Jun; 75(6):1200-3. PMID: 3105914.
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  740. Loscalzo J, Vaughan DE. Tissue plasminogen activator promotes platelet disaggregation in plasma. J Clin Invest. 1987 Jun; 79(6):1749-55. PMID: 2438305; PMCID: PMC424517.
  741. Schafer AI, Zavoico GB, Loscalzo J, Maas AK. Synergistic inhibition of platelet activation by plasmin and prostaglandin I2. Blood. 1987 May; 69(5):1504-7. PMID: 3032310.
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  742. Goldhaber SZ, Markis JE, Kessler CM, Meyerovitz MF, Kim D, Vauchan DE, Selwyn AP, Loscalzo J, Dawley DL, Sharma GV, et al. Perspectives on treatment of acute pulmonary embolism with tissue plasminogen activator. Semin Thromb Hemost. 1987 Apr; 13(2):171-7. PMID: 3114885.
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  743. Janicki JS, Weber KT, Loscalzo J, Shroff S. Extracardiac pressure and ventricular haemodynamics. Cardiovasc Res. 1987 Mar; 21(3):230-9. PMID: 3652089.
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  744. Handin RI, Loscalzo J. Hemostasis, thrombosis, fibrinolysis, and cardiovascular disease. In: Heart Disease. Braunwald E, editor. 1987; 1758-81.
  745. Graboys TB, Grossbard CL, Loscalzo J. Changes in cardiac rhythm among medical house officers undergoing ambulatory electrocardiographic monitoring. J Cardiopulmonary Rehabil. 1987; 7:342-5.
  746. Bonthron DT, Handin RI, Kaufman RJ, Wasley LC, Orr EC, Mitsock LM, Ewenstein B, Loscalzo J, Ginsburg D, Orkin SH. Structure of pre-pro-von Willebrand factor and its expression in heterologous cells. Nature. 1986 Nov 20-26; 324(6094):270-3. PMID: 3491324.
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  747. Goldhaber SZ, Vaughan DE, Markis JE, Selwyn AP, Meyerovitz MF, Loscalzo J, Kim DS, Kessler CM, Dawley DL, Sharma GV, et al. Acute pulmonary embolism treated with tissue plasminogen activator. Lancet. 1986 Oct 18; 2(8512):886-9. PMID: 2876327.
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  748. Loscalzo J, Inbal A, Handin RI. von Willebrand protein facilitates platelet incorporation in polymerizing fibrin. J Clin Invest. 1986 Oct; 78(4):1112-9. PMID: 3489737; PMCID: PMC423774.
  749. Loscalzo J, Rabkin D. The interaction of Tb3+ with the human platelet surface. Arch Biochem Biophys. 1986 Aug 15; 249(1):237-42. PMID: 2943224.
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  750. Loscalzo J. Paradoxical embolism: clinical presentation, diagnostic strategies, and therapeutic options. Am Heart J. 1986 Jul; 112(1):141-5. PMID: 3728270.
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  751. Naftilan AJ, Dzau VJ, Loscalzo J. Preliminary observations on abnormalities of membrane structure and function in essential hypertension. Hypertension. 1986 Jun; 8(6 Pt 2):II174-9. PMID: 3013768.
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  752. Loscalzo J, Freedman J. Purification and characterization of human platelet glutathione-S-transferase. Blood. 1986 Jun; 67(6):1595-9. PMID: 3085745.
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  753. Loscalzo J, Slayter H, Handin RI, Farber D. Subunit structure and assembly of von Willebrand factor polymer: complementary analysis by electron microscopy and quasielastic light scattering. Biophys J. 1986 Jan; 49(1):49-50. PMID: 19431644.
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  754. Michelson AD, Loscalzo J, Melnick B, Coller BS, Handin RI. Partial characterization of a binding site for von Willebrand factor on glycocalicin. Blood. 1986 Jan; 67(1):19-26. PMID: 3000477.
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  755. Loscalzo J, Antman E. Artificial cardiac pacemakers: current concepts. J Crit Care. 1986; 3(1):174-90.
  756. Loscalzo J. N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin. J Clin Invest. 1985 Aug; 76(2):703-8. PMID: 2863286; PMCID: PMC423881.
  757. Loscalzo J, Fisch M, Handin RI. Solution studies of the quaternary structure and assembly of human von Willebrand factor. Biochemistry. 1985 Jul 30; 24(16):4468-75. PMID: 3876847.
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  758. Slayter H, Loscalzo J, Bockenstedt P, Handin RI. Native conformation of human von Willebrand protein. Analysis by electron microscopy and quasi-elastic light scattering. J Biol Chem. 1985 Jul 15; 260(14):8559-63. PMID: 3874208.
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  759. Loscalzo J, Melnick B, Handin RI. The interaction of platelet factor four and glycosaminoglycans. Arch Biochem Biophys. 1985 Jul; 240(1):446-55. PMID: 2409923.
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  760. Adelman B, Michelson AD, Loscalzo J, Greenberg J, Handin RI. Plasmin effect on platelet glycoprotein Ib-von Willebrand factor interactions. Blood. 1985 Jan; 65(1):32-40. PMID: 3155489.
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  761. Shorey J, Bhardwaj N, Loscalzo J. Acute Wernicke's encephalopathy after intravenous infusion of high-dose nitroglycerin. Ann Intern Med. 1984 Oct; 101(4):500. PMID: 6433765.
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  762. Loscalzo J, Handin RI. Conformational domains and structural transitions of human von Willebrand protein. Biochemistry. 1984 Aug 14; 23(17):3880-6. PMID: 6333249.
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  763. Lipton SA, Hickey WF, Morris JH, Loscalzo J. Candidal infection in the central nervous system. Am J Med. 1984 Jan; 76(1):101-8. PMID: 6691350.
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  764. Loscalzo, J., Reed, G.H., Weber, A. How active is actin? Propagated conformational changes in the actin filament. Search and Discovery. A tribute to Albert Szent-Gyorgi. B. Kaminer, eds. 1977; 99-106.
  765. Loscalzo J, Reed GH. Spectroscopic studies of actin-metal-nucleotide complexes. Biochemistry. 1976 Nov 30; 15(24):5407-13. PMID: 187216.
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  766. Loscalzo J, Reed GH, Weber A. Conformational change and cooperativity in actin filaments free of tropomyosin. Proc Natl Acad Sci U S A. 1975 Sep; 72(9):3412-5. PMID: 1103145; PMCID: PMC433003.
  767. Loscalzo J, Kallen RG, Voet D. The x ray structure of thiazolidine-4-carboxylic acid. Arch Biochem Biophys. 1973 Aug; 157(2):426-30. PMID: 4730802.
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