Harvard Catalyst Profiles

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James B. Whitney, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01AI131365 (WHITNEY, JAMES BURTON) Aug 11, 2017 - Jul 31, 2022
    Viral dynamics of rebound and control following early treatment of HIV/SIV
    Role: Principal Investigator
  2. R01AI127089 (WHITNEY, JAMES BURTON) Jul 1, 2016 - Jun 30, 2021
    TLR Immunotherapy to Eradicate Anatomic SIV Reservoirs
    Role: Principal Investigator
  3. R56AI122942 (WHITNEY, JAMES BURTON) Mar 10, 2016 - Feb 28, 2017
    TLR Therapy to Eradicate the SIV Reservoir
    Role: Principal Investigator
  4. R56AI091514 (WHITNEY, JAMES BURTON) Aug 3, 2011 - Jul 31, 2013
    Mechanisms of SIV persistence
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lim SY, Osuna CE, Best K, Taylor R, Chen E, Yoon G, Kublin JL, Schalk D, Schultz-Darken N, Capuano S, Safronetz D, Luo M, MacLennan S, Mathis A, Babu YS, Sheridan WP, Perelson AS, Whitney JB. A direct-acting antiviral drug abrogates viremia in Zika virus-infected rhesus macaques. Sci Transl Med. 2020 Jun 10; 12(547). PMID: 32522808.
  2. Blum FC, Hardy BL, Bishop-Lilly KA, Frey KG, Hamilton T, Whitney JB, Lewis MG, Merrell DS, Mattapallil JJ. Microbial Dysbiosis During Simian Immunodeficiency Virus Infection is Partially Reverted with Combination Anti-retroviral Therapy. Sci Rep. 2020 Apr 14; 10(1):6387. PMID: 32286417.
  3. Whitney JB, Lim SY, Osuna CE, Kublin JL, Chen E, Yoon G, Liu PT, Abbink P, Borducci EN, Hill A, Lewis MG, Geleziunas R, Robb ML, Michael NL, Barouch DH. Prevention of SIVmac251 reservoir seeding in rhesus monkeys by early antiretroviral therapy. Nat Commun. 2018 12 21; 9(1):5429. PMID: 30575753.
    Citations:    Fields:    
  4. Osuna CE, Lim SY, Kublin JL, Apps R, Chen E, Mota TM, Huang SH, Ren Y, Bachtel ND, Tsibris AM, Ackerman ME, Jones RB, Nixon DF, Whitney JB. Publisher Correction: Evidence that CD32a does not mark the HIV-1 latent reservoir. Nature. 2018 11; 563(7733):E33. PMID: 30315222.
    Citations:    Fields:    
  5. Osuna CE, Lim SY, Kublin JL, Apps R, Chen E, Mota TM, Huang SH, Ren Y, Bachtel ND, Tsibris AM, Ackerman ME, Jones RB, Nixon DF, Whitney JB. Evidence that CD32a does not mark the HIV-1 latent reservoir. Nature. 2018 09; 561(7723):E20-E28. PMID: 30232424.
    Citations:    Fields:    
  6. Li H, Hai Y, Lim SY, Toledo N, Crecente-Campo J, Schalk D, Li L, Omange RW, Dacoba TG, Liu LR, Kashem MA, Wan Y, Liang B, Li Q, Rakasz E, Schultz-Darken N, Alonso MJ, Plummer FA, Whitney JB, Luo M. Mucosal antibody responses to vaccines targeting SIV protease cleavage sites or full-length Gag and Env proteins in Mauritian cynomolgus macaques. PLoS One. 2018; 13(8):e0202997. PMID: 30153293.
    Citations:    Fields:    
  7. Bhattacharyya M, Whitney JB, Seaman M, Barouch DH, Penaloza-MacMaster P. T-cell subset differentiation and antibody responses following antiretroviral therapy during simian immunodeficiency virus infection. Immunology. 2018 12; 155(4):458-466. PMID: 30014618.
    Citations:    Fields:    
  8. Lim SY, Osuna CE, Hraber PT, Hesselgesser J, Gerold JM, Barnes TL, Sanisetty S, Seaman MS, Lewis MG, Geleziunas R, Miller MD, Cihlar T, Lee WA, Hill AL, Whitney JB. TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy. Sci Transl Med. 2018 05 02; 10(439). PMID: 29720451.
    Citations: 4     Fields:    
  9. Webb GM, Li S, Mwakalundwa G, Folkvord JM, Greene JM, Reed JS, Stanton JJ, Legasse AW, Hobbs T, Martin LD, Park BS, Whitney JB, Jeng EK, Wong HC, Nixon DF, Jones RB, Connick E, Skinner PJ, Sacha JB. The human IL-15 superagonist ALT-803 directs SIV-specific CD8+ T cells into B-cell follicles. Blood Adv. 2018 01 23; 2(2):76-84. PMID: 29365313.
    Citations: 2     Translation:HumansAnimalsCells
  10. Whitney JB, Brad Jones R. In Vitro and In Vivo Models of HIV Latency. Adv Exp Med Biol. 2018; 1075:241-263. PMID: 30030796.
    Citations:    Fields:    
  11. Osuna CE, Whitney JB. Nonhuman Primate Models of Zika Virus Infection, Immunity, and Therapeutic Development. J Infect Dis. 2017 12 16; 216(suppl_10):S928-S934. PMID: 29267926.
    Citations: 5     Fields:    
  12. Li H, Nykoluk M, Li L, Liu LR, Omange RW, Soule G, Schroeder LT, Toledo N, Kashem MA, Correia-Pinto JF, Liang B, Schultz-Darken N, Alonso MJ, Whitney JB, Plummer FA, Luo M. Natural and cross-inducible anti-SIV antibodies in Mauritian cynomolgus macaques. PLoS One. 2017; 12(10):e0186079. PMID: 28982126.
    Citations: 2     Fields:    Translation:AnimalsCells
  13. Julg B, Liu PT, Wagh K, Fischer WM, Abbink P, Mercado NB, Whitney JB, Nkolola JP, McMahan K, Tartaglia LJ, Borducchi EN, Khatiwada S, Kamath M, LeSuer JA, Seaman MS, Schmidt SD, Mascola JR, Burton DR, Korber BT, Barouch DH. Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931655.
    Citations: 9     Fields:    Translation:AnimalsCells
  14. Kublin JL, Whitney JB. Zika virus research models. Virus Res. 2018 08 02; 254:15-20. PMID: 28811170.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Li H, Omange RW, Czarnecki C, Correia-Pinto JF, Crecente-Campo J, Richmond M, Li L, Schultz-Darken N, Alonso MJ, Whitney JB, Plummer FA, Luo M. Mauritian cynomolgus macaques with M3M4 MHC genotype control SIVmac251 infection. J Med Primatol. 2017 08; 46(4):137-143. PMID: 28748659.
    Citations: 3     Fields:    Translation:AnimalsCells
  16. Best K, Guedj J, Madelain V, de Lamballerie X, Lim SY, Osuna CE, Whitney JB, Perelson AS. Zika plasma viral dynamics in nonhuman primates provides insights into early infection and antiviral strategies. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8847-8852. PMID: 28765371.
    Citations: 5     Fields:    Translation:AnimalsCells
  17. Osuna CE, Lim SY, Deleage C, Griffin BD, Stein D, Schroeder LT, Omage R, Best K, Luo M, Hraber PT, Andersen-Elyard H, Ojeda EF, Huang S, Vanlandingham DL, Higgs S, Perelson AS, Estes JD, Safronetz D, Lewis MG, Whitney JB. Corrigendum: Zika viral dynamics and shedding in rhesus and cynomolgus macaques. Nat Med. 2017 Feb 07; 23(2):264. PMID: 28170376.
    Citations: 1     Fields:    
  18. Osuna CE, Lim SY, Deleage C, Griffin BD, Stein D, Schroeder LT, Omange RW, Best K, Luo M, Hraber PT, Andersen-Elyard H, Ojeda EF, Huang S, Vanlandingham DL, Higgs S, Perelson AS, Estes JD, Safronetz D, Lewis MG, Whitney JB. Zika viral dynamics and shedding in rhesus and cynomolgus macaques. Nat Med. 2016 12; 22(12):1448-1455. PMID: 27694931.
    Citations: 50     Fields:    Translation:AnimalsCells
  19. Moldt B, Le KM, Carnathan DG, Whitney JB, Schultz N, Lewis MG, Borducchi EN, Smith KM, Mackel JJ, Sweat SL, Hodges AP, Godzik A, Parren PW, Silvestri G, Barouch DH, Burton DR. Neutralizing antibody affords comparable protection against vaginal and rectal simian/human immunodeficiency virus challenge in macaques. AIDS. 2016 06 19; 30(10):1543-51. PMID: 27243773.
    Citations: 14     Fields:    Translation:AnimalsCells
  20. Jones RB, Mueller S, O'Connor R, Rimpel K, Sloan DD, Karel D, Wong HC, Jeng EK, Thomas AS, Whitney JB, Lim SY, Kovacs C, Benko E, Karandish S, Huang SH, Buzon MJ, Lichterfeld M, Irrinki A, Murry JP, Tsai A, Yu H, Geleziunas R, Trocha A, Ostrowski MA, Irvine DJ, Walker BD. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog. 2016 Apr; 12(4):e1005545. PMID: 27082643.
    Citations: 28     Fields:    Translation:HumansCells
  21. Tartaglia LJ, Chang HW, Lee BC, Abbink P, Ng'ang'a D, Boyd M, Lavine CL, Lim SY, Sanisetty S, Whitney JB, Seaman MS, Rolland M, Tovanabutra S, Ananworanich J, Robb ML, Kim JH, Michael NL, Barouch DH. Production of Mucosally Transmissible SHIV Challenge Stocks from HIV-1 Circulating Recombinant Form 01_AE env Sequences. PLoS Pathog. 2016 Feb; 12(2):e1005431. PMID: 26849216.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  22. Barouch DH, Alter G, Broge T, Linde C, Ackerman ME, Brown EP, Borducchi EN, Smith KM, Nkolola JP, Liu J, Shields J, Parenteau L, Whitney JB, Abbink P, Ng'ang'a DM, Seaman MS, Lavine CL, Perry JR, Li W, Colantonio AD, Lewis MG, Chen B, Wenschuh H, Reimer U, Piatak M, Lifson JD, Handley SA, Virgin HW, Koutsoukos M, Lorin C, Voss G, Weijtens M, Pau MG, Schuitemaker H. Protective efficacy of adenovirus/protein vaccines against SIV challenges in rhesus monkeys. Science. 2015 Jul 17; 349(6245):320-4. PMID: 26138104.
    Citations: 88     Fields:    Translation:AnimalsCells
  23. Chang HW, Tartaglia LJ, Whitney JB, Lim SY, Sanisetty S, Lavine CL, Seaman MS, Rademeyer C, Williamson C, Ellingson-Strouss K, Stamatatos L, Kublin J, Barouch DH. Generation and evaluation of clade C simian-human immunodeficiency virus challenge stocks. J Virol. 2015 Feb; 89(4):1965-74. PMID: 25473043.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  24. Whitney JB, Hill AL, Sanisetty S, Penaloza-MacMaster P, Liu J, Shetty M, Parenteau L, Cabral C, Shields J, Blackmore S, Smith JY, Brinkman AL, Peter LE, Mathew SI, Smith KM, Borducchi EN, Rosenbloom DI, Lewis MG, Hattersley J, Li B, Hesselgesser J, Geleziunas R, Robb ML, Kim JH, Michael NL, Barouch DH. Rapid seeding of the viral reservoir prior to SIV viraemia in rhesus monkeys. Nature. 2014 Aug 07; 512(7512):74-7. PMID: 25042999.
    Citations: 148     Fields:    Translation:AnimalsCells
  25. Barouch DH, Whitney JB, Moldt B, Klein F, Oliveira TY, Liu J, Stephenson KE, Chang HW, Shekhar K, Gupta S, Nkolola JP, Seaman MS, Smith KM, Borducchi EN, Cabral C, Smith JY, Blackmore S, Sanisetty S, Perry JR, Beck M, Lewis MG, Rinaldi W, Chakraborty AK, Poignard P, Nussenzweig MC, Burton DR. Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys. Nature. 2013 Nov 14; 503(7475):224-8. PMID: 24172905.
    Citations: 221     Fields:    Translation:AnimalsCells
  26. Asmal M, Whitney JB, Luedemann C, Carville A, Steen R, Letvin NL, Geiben-Lynn R. In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes. PLoS One. 2012; 7(11):e48234. PMID: 23133620.
    Citations: 6     Fields:    Translation:AnimalsCells
  27. Whitney JB, Lim SY, Wainberg MA. Evolutionary mechanisms of retroviral persistence. AIDS Rev. 2011 Oct-Dec; 13(4):234-9. PMID: 21975359.
    Citations: 5     Fields:    Translation:HumansCells
  28. Yeh WW, Rao SS, Lim SY, Zhang J, Hraber PT, Brassard LM, Luedemann C, Todd JP, Dodson A, Shen L, Buzby AP, Whitney JB, Korber BT, Nabel GJ, Mascola JR, Letvin NL. The TRIM5 gene modulates penile mucosal acquisition of simian immunodeficiency virus in rhesus monkeys. J Virol. 2011 Oct; 85(19):10389-98. PMID: 21775457.
    Citations: 29     Fields:    Translation:AnimalsCells
  29. Letvin NL, Rao SS, Montefiori DC, Seaman MS, Sun Y, Lim SY, Yeh WW, Asmal M, Gelman RS, Shen L, Whitney JB, Seoighe C, Lacerda M, Keating S, Norris PJ, Hudgens MG, Gilbert PB, Buzby AP, Mach LV, Zhang J, Balachandran H, Shaw GM, Schmidt SD, Todd JP, Dodson A, Mascola JR, Nabel GJ. Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys. Sci Transl Med. 2011 May 04; 3(81):81ra36. PMID: 21543722.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  30. Whitney JB, Asmal M, Geiben-Lynn R. Serpin induced antiviral activity of prostaglandin synthetase-2 against HIV-1 replication. PLoS One. 2011 Apr 12; 6(4):e18589. PMID: 21533265.
    Citations: 10     Fields:    Translation:Cells
  31. Whitney JB, Hraber PT, Luedemann C, Giorgi EE, Daniels MG, Bhattacharya T, Rao SS, Mascola JR, Nabel GJ, Korber BT, Letvin NL. Genital tract sequestration of SIV following acute infection. PLoS Pathog. 2011 Feb; 7(2):e1001293. PMID: 21379569.
    Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
  32. Whitney JB, Mirshahidi S, Lim SY, Goins L, Ibegbu CC, Anderson DC, Raybourne RB, Frankel FR, Lieberman J, Ruprecht RM. Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against HIV. J Immune Based Ther Vaccines. 2011 Jan 18; 9:2. PMID: 21244649.
    Citations: 5     
  33. Masek-Hammerman K, Li H, Liu J, Abbink P, La Porte A, O'Brien KL, Whitney JB, Carville A, Mansfield KG, Barouch DH. Mucosal trafficking of vector-specific CD4+ T lymphocytes following vaccination of rhesus monkeys with adenovirus serotype 5. J Virol. 2010 Oct; 84(19):9810-6. PMID: 20686023.
    Citations: 24     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  34. Lim SY, Chan T, Gelman RS, Whitney JB, O'Brien KL, Barouch DH, Goldstein DB, Haynes BF, Letvin NL. Contributions of Mamu-A*01 status and TRIM5 allele expression, but not CCL3L copy number variation, to the control of SIVmac251 replication in Indian-origin rhesus monkeys. PLoS Genet. 2010 Jun 24; 6(6):e1000997. PMID: 20585621.
    Citations: 30     Fields:    Translation:AnimalsCells
  35. Yeh WW, Rahman I, Hraber P, Coffey RT, Nevidomskyte D, Giri A, Asmal M, Miljkovic S, Daniels M, Whitney JB, Keele BF, Hahn BH, Korber BT, Shaw GM, Seaman MS, Letvin NL. Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys. J Virol. 2010 Jun; 84(12):6018-32. PMID: 20357097.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  36. Lim SY, Rogers T, Chan T, Whitney JB, Kim J, Sodroski J, Letvin NL. TRIM5alpha Modulates Immunodeficiency Virus Control in Rhesus Monkeys. PLoS Pathog. 2010 Jan 22; 6(1):e1000738. PMID: 20107597.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  37. Basavapathruni A, Yeh WW, Coffey RT, Whitney JB, Hraber PT, Giri A, Korber BT, Rao SS, Nabel GJ, Mascola JR, Seaman MS, Letvin NL. Envelope vaccination shapes viral envelope evolution following simian immunodeficiency virus infection in rhesus monkeys. J Virol. 2010 Jan; 84(2):953-63. PMID: 19906933.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  38. Whitney JB, Luedemann C, Bao S, Miura A, Rao SS, Mascola JR, Letvin NL. Monitoring HIV vaccine trial participants for primary infection: studies in the SIV/macaque model. AIDS. 2009 Jul 31; 23(12):1453-60. PMID: 19550289.
    Citations: 12     Fields:    Translation:AnimalsCells
  39. Whitney JB, Luedemann C, Hraber P, Rao SS, Mascola JR, Nabel GJ, Letvin NL. T-cell vaccination reduces simian immunodeficiency virus levels in semen. J Virol. 2009 Oct; 83(20):10840-3. PMID: 19640980.
    Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  40. Mirshahidi S, Kramer VG, Whitney JB, Essono S, Lee S, Dranoff G, Anderson KS, Ruprecht RM. Overlapping synthetic peptides encoding TPD52 as breast cancer vaccine in mice: prolonged survival. Vaccine. 2009 Mar 13; 27(12):1825-33. PMID: 19201387.
    Citations: 7     Fields:    Translation:AnimalsCells
  41. Permar SR, Kang HH, Carville A, Mansfield KG, Gelman RS, Rao SS, Whitney JB, Letvin NL. Potent simian immunodeficiency virus-specific cellular immune responses in the breast milk of simian immunodeficiency virus-infected, lactating rhesus monkeys. J Immunol. 2008 Sep 01; 181(5):3643-50. PMID: 18714039.
    Citations: 21     Fields:    Translation:AnimalsCells
  42. Whitney JB, Wainberg MA. Recovery of fitness of a live attenuated simian immunodeficiency virus through compensation in both the coding and non-coding regions of the viral genome. Retrovirology. 2007 Jul 03; 4:44. PMID: 17608929.
    Citations: 2     Fields:    Translation:AnimalsCells
  43. Whitney JB, Wainberg MA. Impaired RNA incorporation and dimerization in live attenuated leader-variants of SIVmac239. Retrovirology. 2006 Dec 21; 3:96. PMID: 17184529.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  44. Wu Y, Hong K, Chenine AL, Whitney JB, Xu W, Chen Q, Geng Y, Ruprecht RM, Shao Y. Molecular cloning and in vitro evaluation of an infectious simian-human immunodeficiency virus containing env of a primary Chinese HIV-1 subtype C isolate. J Med Primatol. 2005 Apr; 34(2):101-7. PMID: 15860117.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  45. Whitney JB, Ruprecht RM. Live attenuated HIV vaccines: pitfalls and prospects. Curr Opin Infect Dis. 2004 Feb; 17(1):17-26. PMID: 15090885.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  46. Guo X, Hu J, Whitney JB, Russell RS, Liang C. Important role for the CA-NC spacer region in the assembly of bovine immunodeficiency virus Gag protein. J Virol. 2004 Jan; 78(2):551-60. PMID: 14694086.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  47. Liang C, Hu J, Whitney JB, Kleiman L, Wainberg MA. A structurally disordered region at the C terminus of capsid plays essential roles in multimerization and membrane binding of the gag protein of human immunodeficiency virus type 1. J Virol. 2003 Feb; 77(3):1772-83. PMID: 12525611.
    Citations: 39     Fields:    Translation:AnimalsCells
  48. Whitney JB, Oliveira M, Detorio M, Guan Y, Wainberg MA. The M184V mutation in reverse transcriptase can delay reversion of attenuated variants of simian immunodeficiency virus. J Virol. 2002 Sep; 76(17):8958-62. PMID: 12163615.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.