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Vishal S. Vaidya, Ph.D.


Arthur Furst Award for Student Best Paper
Graduate Student Research Achievement Award
2001 - 2002
Grants-In-Aid Research Award
2001 - 2002
Novartis Graduate Student Fellowship Award
Best Paper Award (2nd Place)
Comparative and Veterinary Specialty Section Award for Best Manuscript submitted
Mechanisms Specialty Section's Honorable Mention Award for Best Manuscript submitted
2003 - 2005
National Kidney Foundation Postdoctoral Fellowship Award
Risk Assessment Specialty Section Best Abstract Award

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01ES017543 (VAIDYA, VISHAL S.) Sep 7, 2011 - Mar 31, 2022
    Role of SMOC2 in Kidney Fibrosis
    Role: Principal Investigator
  2. R56ES017543 (VAIDYA, VISHAL S.) Sep 7, 2011 - Apr 30, 2017
    Role of SMOC2 in Kidney Fibrosis
    Role: Principal Investigator
  3. R00ES016723 (VAIDYA, VISHAL S.) Sep 12, 2008 - Jul 31, 2011
    Technology and Endothelial Biology of Kidney Injury Molecule-1
    Role: Principal Investigator
  4. K99ES016723 (VAIDYA, VISHAL S.) Sep 18, 2007 - Aug 31, 2008
    Technology and Endothelial Biology of Kidney Injury Molecule-1
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fader KA, Pardo ID, Kovi RC, Somps CJ, Wang HH, Vaidya VS, Ramaiah SK, Sirivelu MP. Circulating neurofilament light chain as a promising biomarker of AAV-induced dorsal root ganglia toxicity in nonclinical toxicology species. Mol Ther Methods Clin Dev. 2022 Jun 09; 25:264-277. PMID: 35505662; PMCID: PMC9024379.
    Citations: 1     
  2. Xin C, Lei J, Wang Q, Yin Y, Yang X, Moran Guerrero JA, Sabbisetti V, Sun X, Vaidya VS, Bonventre JV. Therapeutic silencing of SMOC2 prevents kidney function loss in mouse model of chronic kidney disease. iScience. 2021 Oct 22; 24(10):103193. PMID: 34703992.
  3. Wagner KR, Guglieri M, Ramaiah SK, Charnas L, Marraffino S, Binks M, Vaidya VS, Palmer J, Goldstein R, Muntoni F. Safety and disease monitoring biomarkers in Duchenne muscular dystrophy: results from a Phase II trial. Biomark Med. 2021 10; 15(15):1389-1396. PMID: 34533053.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  4. Schmidt IM, Colona MR, Kestenbaum BR, Alexopoulos LG, Palsson R, Srivastava A, Liu J, Stillman IE, Rennke HG, Vaidya VS, Wu H, Humphreys BD, Waikar SS. Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis. Kidney Int. 2021 09; 100(3):672-683. PMID: 34051265; PMCID: PMC8384690.
    Citations: 2     Fields:    Translation:Humans
  5. Llewellyn HP, Vaidya VS, Wang Z, Peng Q, Hyde C, Potter D, Wang J, Zong Q, Arat S, Martin M, Masek-Hammerman K, Warner R, Johnson K, Kullak-Ublick GA, Aithal GP, Dear JW, Ramaiah SK. Evaluating the Sensitivity and Specificity of Promising Circulating Biomarkers to Diagnose Liver Injury in Humans. Toxicol Sci. 2021 04 27; 181(1):23-34. PMID: 33483742.
    Citations: 4     Fields:    Translation:HumansAnimals
  6. Fader KA, Zhang J, Menetski JP, Thadhani RI, Antman EM, Friedman GS, Ramaiah SK, Vaidya VS. A Biomarker-Centric Approach to Drug Discovery and Development: Lessons Learned from the Coronavirus Disease 2019 Pandemic. J Pharmacol Exp Ther. 2021 01; 376(1):12-20. PMID: 33115823.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  7. Khodabukus A, Kaza A, Wang J, Prabhu N, Goldstein R, Vaidya VS, Bursac N. Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers. Toxicol Sci. 2020 07 01; 176(1):124-136. PMID: 32294208; PMCID: PMC7643536.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  8. Monteiro MB, Santos-Bezerra DP, Pelaes TS, Vaidya VS, Corrêa-Giannella ML. MicroRNAs 1915-3p, 2861, and 4532 Are Associated with Long-Term Renal Function Decline in Type 1 Diabetes. Clin Chem. 2019 11; 65(11):1458-1459. PMID: 31427290.
    Citations: 1     Fields:    Translation:Humans
  9. Pavkovic M, Pantano L, Gerlach CV, Brutus S, Boswell SA, Everley RA, Shah JV, Sui SH, Vaidya VS. Multi omics analysis of fibrotic kidneys in two mouse models. Sci Data. 2019 06 14; 6(1):92. PMID: 31201317.
    Citations: 10     Fields:    Translation:Animals
  10. Basit A, Radi Z, Vaidya VS, Karasu M, Prasad B. Kidney Cortical Transporter Expression across Species Using Quantitative Proteomics. Drug Metab Dispos. 2019 08; 47(8):802-808. PMID: 31123036.
    Citations: 19     Fields:    Translation:HumansAnimals
  11. Ramm S, Todorov P, Chandrasekaran V, Dohlman A, Monteiro MB, Pavkovic M, Muhlich J, Shankaran H, Chen WW, Mettetal JT, Vaidya VS. A Systems Toxicology Approach for the Prediction of Kidney Toxicity and Its Mechanisms In Vitro. Toxicol Sci. 2019 05 01; 169(1):54-69. PMID: 30649541; PMCID: PMC6484891.
    Citations: 3     Fields:    Translation:HumansCells
  12. Vaidya VS. Introduction: Kidney Safety Science. Semin Nephrol. 2019 03; 39(2):117-119. PMID: 30827334.
    Citations:    Fields:    
  13. Weber EJ, Lidberg KA, Wang L, Bammler TK, MacDonald JW, Li MJ, Redhair M, Atkins WM, Tran C, Hines KM, Herron J, Xu L, Monteiro MB, Ramm S, Vaidya V, Vaara M, Vaara T, Himmelfarb J, Kelly EJ. Human kidney on a chip assessment of polymyxin antibiotic nephrotoxicity. JCI Insight. 2018 12 20; 3(24). PMID: 30568031; PMCID: PMC6338315.
    Citations: 22     Fields:    Translation:HumansAnimals
  14. Monteiro MB, Ramm S, Chandrasekaran V, Boswell SA, Weber EJ, Lidberg KA, Kelly EJ, Vaidya VS. A High-Throughput Screen Identifies DYRK1A Inhibitor ID-8 that Stimulates Human Kidney Tubular Epithelial Cell Proliferation. J Am Soc Nephrol. 2018 12; 29(12):2820-2833. PMID: 30361326; PMCID: PMC6287872.
    Citations: 2     Fields:    Translation:HumansCells
  15. Nabity MB, Polli JW, Vaidya V, Krolewski A, Glaab WE. New Frontiers: Approaches to Understand the Mechanistic Basis of Renal Toxicity. Toxicol Pathol. 2018 12; 46(8):1002-1005. PMID: 30189777.
    Citations:    Fields:    Translation:HumansAnimals
  16. Gerlach CV, Derzi M, Ramaiah SK, Vaidya VS. Industry Perspective on Biomarker Development and Qualification. Clin Pharmacol Ther. 2018 Jan; 103(1):27-31. PMID: 29143971.
    Citations: 2     Fields:    Translation:Humans
  17. Trivedi P, Kumar RK, Iyer A, Boswell S, Gerarduzzi C, Dadhania VP, Herbert Z, Joshi N, Luyendyk JP, Humphreys BD, Vaidya VS. Targeting Phospholipase D4 Attenuates Kidney Fibrosis. J Am Soc Nephrol. 2017 Dec; 28(12):3579-3589. PMID: 28814511; PMCID: PMC5698063.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Cardenas-Gonzalez M, Srivastava A, Pavkovic M, Bijol V, Rennke HG, Stillman IE, Zhang X, Parikh S, Rovin BH, Afkarian M, de Boer IH, Himmelfarb J, Waikar SS, Vaidya VS. Identification, Confirmation, and Replication of Novel Urinary MicroRNA Biomarkers in Lupus Nephritis and Diabetic Nephropathy. Clin Chem. 2017 Sep; 63(9):1515-1526. PMID: 28667184; PMCID: PMC5610914.
    Citations: 34     Fields:    Translation:HumansCells
  19. Gerlach CV, Vaidya VS. MicroRNAs in injury and repair. Arch Toxicol. 2017 Aug; 91(8):2781-2797. PMID: 28501916; PMCID: PMC5843992.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  20. Gerarduzzi C, Kumar RK, Trivedi P, Ajay AK, Iyer A, Boswell S, Hutchinson JN, Waikar SS, Vaidya VS. Silencing SMOC2 ameliorates kidney fibrosis by inhibiting fibroblast to myofibroblast transformation. JCI Insight. 2017 Apr 20; 2(8). PMID: 28422762.
    Citations: 20     Fields:    
  21. Ramm S, Adler M, Vaidya VS. A High-Throughput Screening Assay to Identify Kidney Toxic Compounds. Curr Protoc Toxicol. 2016 08 01; 69:9.10.1-9.10.26. PMID: 27479365.
    Citations: 6     Fields:    Translation:HumansCells
  22. Cárdenas-González M, Osorio-Yáñez C, Gaspar-Ramírez O, Pavkovic M, Ochoa-Martínez A, López-Ventura D, Medeiros M, Barbier OC, Pérez-Maldonado IN, Sabbisetti VS, Bonventre JV, Vaidya VS. Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1. Environ Res. 2016 10; 150:653-662. PMID: 27431456; PMCID: PMC5003729.
    Citations: 26     Fields:    Translation:HumansPHPublic Health
  23. Jadhav S, Ajay AK, Trivedi P, Seematti J, Pellegrini K, Craciun F, Vaidya VS. RNA-binding Protein Musashi Homologue 1 Regulates Kidney Fibrosis by Translational Inhibition of p21 and Numb mRNA. J Biol Chem. 2016 Jul 01; 291(27):14085-14094. PMID: 27129280.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  24. Pavkovic M, Robinson-Cohen C, Chua AS, Nicoara O, Cárdenas-González M, Bijol V, Ramachandran K, Hampson L, Pirmohamed M, Antoine DJ, Frendl G, Himmelfarb J, Waikar SS, Vaidya VS. Detection of Drug-Induced Acute Kidney Injury in Humans Using Urinary KIM-1, miR-21, -200c, and -423. Toxicol Sci. 2016 07; 152(1):205-13. PMID: 27122240; PMCID: PMC5009468.
    Citations: 26     Fields:    Translation:HumansCells
  25. Pavkovic M, Vaidya VS. MicroRNAs and drug-induced kidney injury. Pharmacol Ther. 2016 07; 163:48-57. PMID: 27126472; PMCID: PMC4887322.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  26. Prozialeck WC, VanDreel A, Ackerman CD, Stock I, Papaeliou A, Yasmine C, Wilson K, Lamar PC, Sears VL, Gasiorowski JZ, DiNovo KM, Vaidya VS, Edwards JR. Evaluation of cystatin C as an early biomarker of cadmium nephrotoxicity in the rat. Biometals. 2016 Feb; 29(1):131-46. PMID: 26715107; PMCID: PMC4735246.
    Citations: 10     Fields:    Translation:HumansAnimals
  27. Pellegrini KL, Gerlach CV, Craciun FL, Ramachandran K, Bijol V, Kissick HT, Vaidya VS. Application of small RNA sequencing to identify microRNAs in acute kidney injury and fibrosis. Toxicol Appl Pharmacol. 2016 Dec 01; 312:42-52. PMID: 26707937; PMCID: PMC4912473.
    Citations: 21     Fields:    Translation:Animals
  28. Craciun FL, Bijol V, Ajay AK, Rao P, Kumar RK, Hutchinson J, Hofmann O, Joshi N, Luyendyk JP, Kusebauch U, Moss CL, Srivastava A, Himmelfarb J, Waikar SS, Moritz RL, Vaidya VS. RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis. J Am Soc Nephrol. 2016 06; 27(6):1702-13. PMID: 26449608; PMCID: PMC4884105.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  29. Adler M, Ramm S, Hafner M, Muhlich JL, Gottwald EM, Weber E, Jaklic A, Ajay AK, Svoboda D, Auerbach S, Kelly EJ, Himmelfarb J, Vaidya VS. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr; 27(4):1015-28. PMID: 26260164; PMCID: PMC4814182.
    Citations: 38     Fields:    Translation:HumansCells
  30. Chung HJ, Pellegrini KL, Chung J, Wanigasuriya K, Jayawardene I, Lee K, Lee H, Vaidya VS, Weissleder R. Nanoparticle Detection of Urinary Markers for Point-of-Care Diagnosis of Kidney Injury. PLoS One. 2015; 10(7):e0133417. PMID: 26186708.
    Citations: 7     Fields:    Translation:Humans
  31. Murugaiyan G, da Cunha AP, Ajay AK, Joller N, Garo LP, Kumaradevan S, Yosef N, Vaidya VS, Weiner HL. MicroRNA-21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J Clin Invest. 2015 Mar 02; 125(3):1069-80. PMID: 25642768; PMCID: PMC4362225.
    Citations: 99     Fields:    Translation:AnimalsCells
  32. Legrand M, De Berardinis B, Gaggin HK, Magrini L, Belcher A, Zancla B, Femia A, Simon M, Motiwala S, Sambhare R, Di Somma S, Mebazaa A, Vaidya VS, Januzzi JL. Evidence of uncoupling between renal dysfunction and injury in cardiorenal syndrome: insights from the BIONICS study. PLoS One. 2014; 9(11):e112313. PMID: 25386851; PMCID: PMC4227686.
    Citations: 14     Fields:    Translation:Humans
  33. Pellegrini KL, Han T, Bijol V, Saikumar J, Craciun FL, Chen WW, Fuscoe JC, Vaidya VS. MicroRNA-155 deficient mice experience heightened kidney toxicity when dosed with cisplatin. Toxicol Sci. 2014 Oct; 141(2):484-92. PMID: 25015656.
    Citations: 22     Fields:    Translation:AnimalsCells
  34. Craciun FL, Ajay AK, Hoffmann D, Saikumar J, Fabian SL, Bijol V, Humphreys BD, Vaidya VS. Pharmacological and genetic depletion of fibrinogen protects from kidney fibrosis. Am J Physiol Renal Physiol. 2014 Aug 15; 307(4):F471-84. PMID: 25007874.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  35. Saikumar J, Ramachandran K, Vaidya VS. Noninvasive micromarkers. Clin Chem. 2014 Sep; 60(9):1158-73. PMID: 24407912.
    Citations: 17     Fields:    Translation:Humans
  36. Zhang Q, Davis KJ, Hoffmann D, Vaidya VS, Brown RP, Goering PL. Urinary biomarkers track the progression of nephropathy in hypertensive and obese rats. Biomark Med. 2014; 8(1):85-94. PMID: 24325231.
    Citations: 10     Fields:    Translation:Animals
  37. Veuthey T, Hoffmann D, Vaidya VS, Wessling-Resnick M. Impaired renal function and development in Belgrade rats. Am J Physiol Renal Physiol. 2014 Feb 01; 306(3):F333-43. PMID: 24226520.
    Citations: 12     Fields:    Translation:Animals
  38. Ajay AK, Kim TM, Ramirez-Gonzalez V, Park PJ, Frank DA, Vaidya VS. A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury. J Am Soc Nephrol. 2014 Jan; 25(1):105-18. PMID: 24158981.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  39. Ramachandran K, Saikumar J, Bijol V, Koyner JL, Qian J, Betensky RA, Waikar SS, Vaidya VS. Human miRNome profiling identifies microRNAs differentially present in the urine after kidney injury. Clin Chem. 2013 Dec; 59(12):1742-52. PMID: 24153252.
    Citations: 57     Fields:    Translation:Humans
  40. Campion S, Aubrecht J, Boekelheide K, Brewster DW, Vaidya VS, Anderson L, Burt D, Dere E, Hwang K, Pacheco S, Saikumar J, Schomaker S, Sigman M, Goodsaid F. The current status of biomarkers for predicting toxicity. Expert Opin Drug Metab Toxicol. 2013 Nov; 9(11):1391-408. PMID: 23961847.
    Citations: 22     Fields:    Translation:HumansAnimals
  41. Ajay AK, Saikumar J, Bijol V, Vaidya VS. Heterozygosity for fibrinogen results in efficient resolution of kidney ischemia reperfusion injury. PLoS One. 2012; 7(9):e45628. PMID: 23029147.
    Citations: 11     Fields:    Translation:AnimalsCells
  42. Hoffmann D, Bijol V, Krishnamoorthy A, Gonzalez VR, Frendl G, Zhang Q, Goering PL, Brown RP, Waikar SS, Vaidya VS. Fibrinogen excretion in the urine and immunoreactivity in the kidney serves as a translational biomarker for acute kidney injury. Am J Pathol. 2012 Sep; 181(3):818-28. PMID: 22819533; PMCID: PMC3432430.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  43. Saikumar J, Hoffmann D, Kim TM, Gonzalez VR, Zhang Q, Goering PL, Brown RP, Bijol V, Park PJ, Waikar SS, Vaidya VS. Expression, circulation, and excretion profile of microRNA-21, -155, and -18a following acute kidney injury. Toxicol Sci. 2012 Oct; 129(2):256-67. PMID: 22705808.
    Citations: 84     Fields:    Translation:HumansAnimals
  44. Gardiner L, Akintola A, Chen G, Catania JM, Vaidya V, Burghardt RC, Bonventre JV, Trzeciakowski J, Parrish AR. Structural equation modeling highlights the potential of Kim-1 as a biomarker for chronic kidney disease. Am J Nephrol. 2012; 35(2):152-63. PMID: 22269876.
    Citations: 14     Fields:    Translation:Animals
  45. Kim TM, Ramírez V, Barrera-Chimal J, Bobadilla NA, Park PJ, Vaidya VS. Gene expression analysis reveals the cell cycle and kinetochore genes participating in ischemia reperfusion injury and early development in kidney. PLoS One. 2011; 6(9):e25679. PMID: 21980527.
    Citations: 6     Fields:    Translation:AnimalsCells
  46. Krishnamoorthy A, Ajay AK, Hoffmann D, Kim TM, Ramirez V, Campanholle G, Bobadilla NA, Waikar SS, Vaidya VS. Fibrinogen ß-derived Bß(15-42) peptide protects against kidney ischemia/reperfusion injury. Blood. 2011 Aug 18; 118(7):1934-42. PMID: 21685370; PMCID: PMC3158721.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  47. Endre ZH, Pickering JW, Walker RJ, Devarajan P, Edelstein CL, Bonventre JV, Frampton CM, Bennett MR, Ma Q, Sabbisetti VS, Vaidya VS, Walcher AM, Shaw GM, Henderson SJ, Nejat M, Schollum JB, George PM. Improved performance of urinary biomarkers of acute kidney injury in the critically ill by stratification for injury duration and baseline renal function. Kidney Int. 2011 May; 79(10):1119-30. PMID: 21307838.
    Citations: 105     Fields:    Translation:Humans
  48. El Sabbahy M, Vaidya VS. Ischemic kidney injury and mechanisms of tissue repair. Wiley Interdiscip Rev Syst Biol Med. 2011 Sep-Oct; 3(5):606-18. PMID: 21197658.
    Citations: 39     Fields:    Translation:HumansCells
  49. Vaidya VS, Niewczas MA, Ficociello LH, Johnson AC, Collings FB, Warram JH, Krolewski AS, Bonventre JV. Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-ß-D-glucosaminidase. Kidney Int. 2011 Feb; 79(4):464-70. PMID: 20980978.
    Citations: 102     Fields:    Translation:Humans
  50. Koyner JL, Vaidya VS, Bennett MR, Ma Q, Worcester E, Akhter SA, Raman J, Jeevanandam V, O'Connor MF, Devarajan P, Bonventre JV, Murray PT. Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury. Clin J Am Soc Nephrol. 2010 Dec; 5(12):2154-65. PMID: 20798258.
    Citations: 134     Fields:    Translation:Humans
  51. Krishnamoorthy A, Clement ME, O'Leary E, Bonventre JV, Vaidya VS. TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity. Toxicol Sci. 2010 Nov; 118(1):298-306. PMID: 20702592.
    Citations: 6     Fields:    Translation:Animals
  52. Damman K, Van Veldhuisen DJ, Navis G, Vaidya VS, Smilde TD, Westenbrink BD, Bonventre JV, Voors AA, Hillege HL. Tubular damage in chronic systolic heart failure is associated with reduced survival independent of glomerular filtration rate. Heart. 2010 Aug; 96(16):1297-302. PMID: 20659949; PMCID: PMC3480323.
    Citations: 73     Fields:    Translation:Humans
  53. Vaidya VS, Ozer JS, Dieterle F, Collings FB, Ramirez V, Troth S, Muniappa N, Thudium D, Gerhold D, Holder DJ, Bobadilla NA, Marrer E, Perentes E, Cordier A, Vonderscher J, Maurer G, Goering PL, Sistare FD, Bonventre JV. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol. 2010 May; 28(5):478-85. PMID: 20458318.
    Citations: 206     Fields:    Translation:Animals
  54. Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F. Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol. 2010 May; 28(5):436-40. PMID: 20458311.
    Citations: 165     Fields:    Translation:HumansAnimals
  55. Espandiari P, Rosenzweig B, Zhang J, Zhou Y, Schnackenberg L, Vaidya VS, Goering PL, Brown RP, Bonventre JV, Mahjoob K, Holland RD, Beger RD, Thompson K, Hanig J, Sadrieh N. Age-related differences in susceptibility to cisplatin-induced renal toxicity. J Appl Toxicol. 2010 Mar; 30(2):172-82. PMID: 19839026.
    Citations: 11     Fields:    Translation:HumansAnimals
  56. Hoffmann D, Adler M, Vaidya VS, Rached E, Mulrane L, Gallagher WM, Callanan JJ, Gautier JC, Matheis K, Staedtler F, Dieterle F, Brandenburg A, Sposny A, Hewitt P, Ellinger-Ziegelbauer H, Bonventre JV, Dekant W, Mally A. Performance of novel kidney biomarkers in preclinical toxicity studies. Toxicol Sci. 2010 Jul; 116(1):8-22. PMID: 20118187.
    Citations: 20     Fields:    Translation:AnimalsCells
  57. Ferguson MA, Vaidya VS, Waikar SS, Collings FB, Sunderland KE, Gioules CJ, Bonventre JV. Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury. Kidney Int. 2010 Apr; 77(8):708-14. PMID: 19940842.
    Citations: 61     Fields:    Translation:HumansAnimals
  58. Vishal S. Vaidya and Joseph V. Bonventre. Biomarkers of Toxicity: A New Era in Medicine. 2009.
  59. Zhang J, Goering PL, Espandiari P, Shaw M, Bonventre JV, Vaidya VS, Brown RP, Keenan J, Kilty CG, Sadrieh N, Hanig JP. Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine. Toxicol Pathol. 2009 Aug; 37(5):629-43. PMID: 19535489.
    Citations: 9     Fields:    Translation:Animals
  60. Nijboer WN, Schuurs TA, Damman J, van Goor H, Vaidya VS, van der Heide JJ, Leuvenink HG, Bonventre JV, Ploeg RJ. Kidney injury molecule-1 is an early noninvasive indicator for donor brain death-induced injury prior to kidney transplantation. Am J Transplant. 2009 Aug; 9(8):1752-9. PMID: 19522876.
    Citations: 12     Fields:    Translation:HumansAnimals
  61. Vaidya VS, Ford GM, Waikar SS, Wang Y, Clement MB, Ramirez V, Glaab WE, Troth SP, Sistare FD, Prozialeck WC, Edwards JR, Bobadilla NA, Mefferd SC, Bonventre JV. A rapid urine test for early detection of kidney injury. Kidney Int. 2009 Jul; 76(1):108-14. PMID: 19387469.
    Citations: 72     Fields:    Translation:HumansAnimals
  62. Sieber M, Hoffmann D, Adler M, Vaidya VS, Clement M, Bonventre JV, Zidek N, Rached E, Amberg A, Callanan JJ, Dekant W, Mally A. Comparative analysis of novel noninvasive renal biomarkers and metabonomic changes in a rat model of gentamicin nephrotoxicity. Toxicol Sci. 2009 Jun; 109(2):336-49. PMID: 19349640.
    Citations: 34     Fields:    Translation:Animals
  63. Kramer AB, van Timmeren MM, Schuurs TA, Vaidya VS, Bonventre JV, van Goor H, Navis G. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time. Am J Physiol Renal Physiol. 2009 May; 296(5):F1136-45. PMID: 19225054.
    Citations: 28     Fields:    Translation:Animals
  64. Prozialeck WC, Edwards JR, Vaidya VS, Bonventre JV. Preclinical evaluation of novel urinary biomarkers of cadmium nephrotoxicity. Toxicol Appl Pharmacol. 2009 Aug 01; 238(3):301-5. PMID: 19371616.
    Citations: 22     Fields:    Translation:AnimalsCells
  65. Vaidya VS, Ferguson MA, Bonventre JV. . Biomarkers of Acute Kidney Injury. Comprehensive Toxicology: Renal Toxicology, ed: Rick Schnellmann. 2009; Submitted.
  66. Prozialeck WC, Edwards JR, Lamar PC, Liu J, Vaidya VS, Bonventre JV. Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury. Toxicol Appl Pharmacol. 2009 Aug 01; 238(3):306-14. PMID: 19371613.
    Citations: 41     Fields:    Translation:AnimalsCells
  67. Vaidya VS, Ford GF, Yizhou W, Ramirez V, Glaab WE, Troth SP, Sistare FD, Prozialeck WC, Edwards JR, Bobadilla NA, Mefferd S and Bonventre JV. RenaStick: A Rapid Urine Test for Early Detection of Kidney Injury. 2008; In Preparation.
  68. Vaidya VS, Niewczas MA, Collings FB, Ficociello LH, Johnson A, Walker W, Warram JH, Krolewski AS, and Bonventre JV . Urinary Markers of Tubular Injury are Associated with Regression and Progression of Microalbuminuria in Type 1 Diabetes. 2008; In preparation.
  69. Vaidya VS, Waikar SS, Ferguson MA, Ferguson MA, Collings FB, Sunderland K, Gioules C, Bradwin G, Matsouaka R, Betensky RA, Curhan GC, Bonventre JV. Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans. Clin Transl Sci. 2008 Dec; 1(3):200-8. PMID: 19212447.
    Citations: 148     Fields:    Translation:Humans
  71. Koyner JL, Vaidya VS, Trevino S, Bonventre JV, Murray PT. Kidney Injury Molecule1 (KIM1) Is an Early Biomarker of Acute Kidney Injury (AKI) Following Cardiac Surgery. JASN. 2008; 19:568A.
  72. Koyner JL, Vaidya VS, Bennett M, Trevino S, Devarajan P, Bonventre JV, Murray PT. Urinary Neutrophil Gelatinase Associated Lipocalin (NGAL) Predicts Severity of Injury in Patients Developing Acute Kidney Injury (AKI) Following Adult Cardiac Surgery. JASN. 2008; 19:566A.
  73. Waikar SS, Vaidya VS, Gioules C, Sunderland K, Collings FB, Curhan GC, Frendl G, Sugarbaker DJ, Bonventre JV. Urinary Biomarkers of Acute Kidney Injury in a High Risk Cohort: Cytoreductive Surgery and Intracavitary Cisplatin Lavage for Mesothelioma. JASN. 2008; 19:569A.
  74. Vaidya VS, Niewczas M, Ficociello LH, Collings FB, Walker W, Warram JH, Bonventre JV, Krolewski A. Markers of Tubular Injury, NAG and KIM-1, Are Predictors for Remission and Progression of Mircoalbuminuria in Type 1 Diabetes. JASN. 2008; 19:27A.
  75. Chagnon F, Vaidya VS, Plante GE, Bonventre JV, Bernard A, Guindi C, Lesur O. Modulation of aquaporin-2/vasopressin2 receptor kidney expression and tubular injury after endotoxin (lipopolysaccharide) challenge. Crit Care Med. 2008 Nov; 36(11):3054-61. PMID: 18824919; PMCID: PMC2745282.
    Citations: 8     Fields:    Translation:Animals
  76. Waanders F, Vaidya VS, van Goor H, Leuvenink H, Damman K, Hamming I, Bonventre JV, Vogt L, Navis G. Effect of renin-angiotensin-aldosterone system inhibition, dietary sodium restriction, and/or diuretics on urinary kidney injury molecule 1 excretion in nondiabetic proteinuric kidney disease: a post hoc analysis of a randomized controlled trial. Am J Kidney Dis. 2009 Jan; 53(1):16-25. PMID: 18823687; PMCID: PMC3298772.
    Citations: 43     Fields:    Translation:Humans
  77. Trujillo J, Cruz C, Tovar A, Vaidya V, Zambrano E, Bonventre JV, Gamba G, Torres N, Bobadilla NA. Renoprotective mechanisms of soy protein intake in the obese Zucker rat. Am J Physiol Renal Physiol. 2008 Nov; 295(5):F1574-82. PMID: 18815216; PMCID: PMC4747908.
    Citations: 4     Fields:    Translation:AnimalsCells
  78. Zhang J, Brown RP, Shaw M, Vaidya VS, Zhou Y, Espandiari P, Sadrieh N, Stratmeyer M, Keenan J, Kilty CG, Bonventre JV, Goering PL. Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine. Toxicol Pathol. 2008 Apr; 36(3):397-409. PMID: 18441258.
    Citations: 21     Fields:    Translation:AnimalsCells
  79. Ferguson MA, Vaidya VS, Bonventre JV. Biomarkers of nephrotoxic acute kidney injury. Toxicology. 2008 Mar 20; 245(3):182-93. PMID: 18294749.
    Citations: 80     Fields:    Translation:HumansAnimals
  80. Vaidya VS, Ferguson MA, Ferguson MA, Bonventre JV. Biomarkers of acute kidney injury. Annu Rev Pharmacol Toxicol. 2008; 48:463-93. PMID: 17937594.
    Citations: 201     Fields:    Translation:HumansAnimals
  81. van Timmeren MM, Vaidya VS, van Ree RM, Oterdoom LH, de Vries AP, Gans RO, van Goor H, Stegeman CA, Bonventre JV, Bakker SJ. High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients. Transplantation. 2007 Dec 27; 84(12):1625-30. PMID: 18165774.
    Citations: 67     Fields:    Translation:Humans
  82. Collings FB, Vaidya VS. Novel technologies for the discovery and quantitation of biomarkers of toxicity. Toxicology. 2008 Mar 20; 245(3):167-74. PMID: 18237837.
    Citations: 6     Fields:    Translation:HumansAnimals
  83. Zhou Y, Vaidya VS, Brown RP, Zhang J, Rosenzweig BA, Thompson KL, Miller TJ, Bonventre JV, Goering PL. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol Sci. 2008 Jan; 101(1):159-70. PMID: 17934191.
    Citations: 90     Fields:    Translation:Animals
  84. Prozialeck WC, Vaidya VS, Liu J, Waalkes MP, Edwards JR, Lamar PC, Bernard AM, Dumont X, Bonventre JV. Kidney injury molecule-1 is an early biomarker of cadmium nephrotoxicity. Kidney Int. 2007 Oct; 72(8):985-93. PMID: 17687258; PMCID: PMC2747605.
    Citations: 68     Fields:    Translation:Animals
  85. Chen G, Bridenbaugh EA, Akintola AD, Catania JM, Vaidya VS, Bonventre JV, Dearman AC, Sampson HW, Zawieja DC, Burghardt RC, Parrish AR. Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction. Am J Physiol Renal Physiol. 2007 Oct; 293(4):F1272-81. PMID: 17670906; PMCID: PMC2758575.
    Citations: 37     Fields:    Translation:Animals
  86. Espandiari P, Zhang J, Rosenzweig BA, Vaidya VS, Sun J, Schnackenberg L, Herman EH, Knapton A, Bonventre JV, Beger RD, Thompson KL, Hanig J. The utility of a rodent model in detecting pediatric drug-induced nephrotoxicity. Toxicol Sci. 2007 Oct; 99(2):637-48. PMID: 17636248; PMCID: PMC2729403.
    Citations: 11     Fields:    Translation:Animals
  87. Liangos O, Perianayagam MC, Vaidya VS, Han WK, Wald R, Tighiouart H, MacKinnon RW, Li L, Balakrishnan VS, Pereira BJ, Bonventre JV, Jaber BL. Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure. J Am Soc Nephrol. 2007 Mar; 18(3):904-12. PMID: 17267747.
    Citations: 161     Fields:    Translation:Humans
  88. Duffield JS, Hong S, Vaidya VS, Lu Y, Fredman G, Serhan CN, Bonventre JV. Resolvin D series and protectin D1 mitigate acute kidney injury. J Immunol. 2006 Nov 01; 177(9):5902-11. PMID: 17056514.
    Citations: 160     Fields:    Translation:AnimalsCells
  89. Vaidya VS, Bonventre JV. Mechanistic biomarkers for cytotoxic acute kidney injury. Expert Opin Drug Metab Toxicol. 2006 Oct; 2(5):697-713. PMID: 17014390.
    Citations: 23     Fields:    Translation:HumansAnimals
  90. de Borst MH, van Timmeren MM, Vaidya VS, de Boer RA, van Dalen MB, Kramer AB, Schuurs TA, Bonventre JV, Navis G, van Goor H. Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F313-20. PMID: 16896183.
    Citations: 29     Fields:    Translation:Animals
  91. Pérez-Rojas J, Blanco JA, Cruz C, Trujillo J, Vaidya VS, Uribe N, Bonventre JV, Gamba G, Bobadilla NA. Mineralocorticoid receptor blockade confers renoprotection in preexisting chronic cyclosporine nephrotoxicity. Am J Physiol Renal Physiol. 2007 Jan; 292(1):F131-9. PMID: 16835406.
    Citations: 30     Fields:    Translation:Animals
  92. van Timmeren MM, Bakker SJ, Vaidya VS, Bailly V, Schuurs TA, Damman J, Stegeman CA, Bonventre JV, van Goor H. Tubular kidney injury molecule-1 in protein-overload nephropathy. Am J Physiol Renal Physiol. 2006 Aug; 291(2):F456-64. PMID: 16467126.
    Citations: 68     Fields:    Translation:Animals
  93. Vaidya VS, Ramirez V, Ichimura T, Bobadilla NA, Bonventre JV. Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury. Am J Physiol Renal Physiol. 2006 Feb; 290(2):F517-29. PMID: 16174863.
    Citations: 229     Fields:    Translation:AnimalsCells
  94. Sheridan AM, Vaidya VS, Mehendale HM. Cell cycle. Encyclopedia of Toxicology, by Philip Wexler. 2005; 1:490-495.
  95. Vaidya VS, Mehendale HM. . Mercuric chloride. Encyclopedia of Toxicology, by Philip Wexler. 2005; 3:33-36.
  96. Vaidya VS, Mehendale HM. S-(1,2-dichlorovinyl)-L-cysteine. Encyclopedia of Toxicology, by Philip Wexler. 2005; 3:747-750.
  97. Vaidya VS, Nicholson JK, Mehendale HM. Metabonomics. Encyclopedia of Toxicology, by Philip Wexler. 2005; 3:41-46.
  98. Vaidya VS, Mehendale HM. . Ephedra. Encyclopedia of Toxicology, by Philip Wexler. 2005; 2:223-228.
  99. Vaidya VS, Shankar K, Lock EA, Dixon D, Mehendale HM. Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway. Toxicol Pathol. 2003 Nov-Dec; 31(6):604-18. PMID: 14585728.
    Citations: 6     Fields:    Translation:AnimalsCells
  100. Anand SS, Murthy SN, Vaidya VS, Mumtaz MM, Mehendale HM. Tissue repair plays pivotal role in final outcome of liver injury following chloroform and allyl alcohol binary mixture. Food Chem Toxicol. 2003 Aug; 41(8):1123-32. PMID: 12842180.
    Citations: 2     Fields:    Translation:Animals
  101. Shankar K, Vaidya VS, Corton JC, Bucci TJ, Liu J, Waalkes MP, Mehendale HM. Activation of PPAR-alpha in streptozotocin-induced diabetes is essential for resistance against acetaminophen toxicity. FASEB J. 2003 Sep; 17(12):1748-50. PMID: 12958197.
    Citations: 11     Fields:    Translation:Animals
  102. Vaidya VS, Shankar K, Lock EA, Bucci TJ, Mehendale HM. Role of tissue repair in survival from s-(1,2-dichlorovinyl)-L-cysteine-induced acute renal tubular necrosis in the mouse. Toxicol Sci. 2003 Jul; 74(1):215-27. PMID: 12730612.
    Citations: 7     Fields:    Translation:AnimalsCells
  103. Shankar K, Vaidya VS, Apte UM, Manautou JE, Ronis MJ, Bucci TJ, Mehendale HM. Type 1 diabetic mice are protected from acetaminophen hepatotoxicity. Toxicol Sci. 2003 Jun; 73(2):220-34. PMID: 12700423.
    Citations: 11     Fields:    Translation:AnimalsCells
  104. Shankar K, Vaidya VS, Wang T, Bucci TJ, Mehendale HM. Streptozotocin-induced diabetic mice are resistant to lethal effects of thioacetamide hepatotoxicity. Toxicol Appl Pharmacol. 2003 Apr 15; 188(2):122-34. PMID: 12691730.
    Citations: 6     Fields:    Translation:Animals
  105. Vaidya VS, Shankar K, Lock EA, Bucci TJ, Mehendale HM. Renal injury and repair following S-1, 2 dichlorovinyl-L-cysteine administration to mice. Toxicol Appl Pharmacol. 2003 Apr 15; 188(2):110-21. PMID: 12691729.
    Citations: 9     Fields:    Translation:Animals
  106. Anand SS, Soni MG, Vaidya VS, Murthy SN, Mumtaz MM, Mehendale HM. Extent and timeliness of tissue repair determines the dose-related hepatotoxicity of chloroform. Int J Toxicol. 2003 Jan-Feb; 22(1):25-33. PMID: 12573946.
    Citations: 2     Fields:    Translation:Animals
  107. Apte UM, Limaye PB, Ramaiah SK, Vaidya VS, Bucci TJ, Warbritton A, Mehendale HM. Upregulated promitogenic signaling via cytokines and growth factors: potential mechanism of robust liver tissue repair in calorie-restricted rats upon toxic challenge. Toxicol Sci. 2002 Oct; 69(2):448-59. PMID: 12377994.
    Citations: 10     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.