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Jennifer Smith, Ph.D.

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This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
ICCB-Longwood Screening Facility (HMS) - Core services (5), Gene knockdown screening libraries (22), Instruments (36), Small molecule Screening libraries (62) and Software (3)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Smith JA, Haberstroh FS, White EA, Livingston DM, DeCaprio JA, Howley PM. SMCX and components of the TIP60 complex contribute to E2 regulation of the HPV E6/E7 promoter. Virology. 2014 Nov; 468-470:311-321. PMID: 25222147.
    View in: PubMed
  2. Mohr SE, Smith JA, Shamu CE, Neumüller RA, Perrimon N. RNAi screening comes of age: improved techniques and complementary approaches. Nat Rev Mol Cell Biol. 2014 Sep; 15(9):591-600. PMID: 25145850; PMCID: PMC4204798.
  3. Yilmazel B, Hu Y, Sigoillot F, Smith JA, Shamu CE, Perrimon N, Mohr SE. Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. BMC Bioinformatics. 2014 Jun 17; 15:192. PMID: 24934636; PMCID: PMC4073188.
  4. Rahman S, Sowa ME, Ottinger M, Smith JA, Shi Y, Harper JW, Howley PM. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol Cell Biol. 2011 Jul; 31(13):2641-52. PMID: 21555454; PMCID: PMC3133372.
  5. Powell ML, Smith JA, Sowa ME, Harper JW, Iftner T, Stubenrauch F, Howley PM. NCoR1 mediates papillomavirus E8;E2C transcriptional repression. J Virol. 2010 May; 84(9):4451-60. PMID: 20181716; PMCID: PMC2863743.
  6. Smith JA, White EA, Sowa ME, Powell ML, Ottinger M, Harper JW, Howley PM. Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3752-7. PMID: 20133580; PMCID: PMC2840515.
  7. Ottinger M, Smith JA, Schweiger MR, Robbins D, Powell ML, You J, Howley PM. Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2. Virology. 2009 Dec 20; 395(2):161-71. PMID: 19836046; PMCID: PMC2787971.
  8. Zheng G, Schweiger MR, Martinez-Noel G, Zheng L, Smith JA, Harper JW, Howley PM. Brd4 regulation of papillomavirus protein E2 stability. J Virol. 2009 Sep; 83(17):8683-92. PMID: 19553317; PMCID: PMC2738164.
  9. Goodman AG, Smith JA, Balachandran S, Perwitasari O, Proll SC, Thomas MJ, Korth MJ, Barber GN, Schiff LA, Katze MG. The cellular protein P58IPK regulates influenza virus mRNA translation and replication through a PKR-mediated mechanism. J Virol. 2007 Mar; 81(5):2221-30. PMID: 17166899; PMCID: PMC1865913.
  10. Smith JA, Schmechel SC, Raghavan A, Abelson M, Reilly C, Katze MG, Kaufman RJ, Bohjanen PR, Schiff LA. Reovirus induces and benefits from an integrated cellular stress response. J Virol. 2006 Feb; 80(4):2019-33. PMID: 16439558; PMCID: PMC1367166.
  11. Smith JA, Schmechel SC, Williams BR, Silverman RH, Schiff LA. Involvement of the interferon-regulated antiviral proteins PKR and RNase L in reovirus-induced shutoff of cellular translation. J Virol. 2005 Feb; 79(4):2240-50. PMID: 15681426; PMCID: PMC546589.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.