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Omid Cameron Farokhzad, M.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Development of Targeted Nanoparticle to Facilitate Drug Delivery for Treating Atherosclerois
Summer, 06/25/07 - 08/17/07

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL127464 (TABAS, IRA A) Jan 1, 2016 - Dec 31, 2019
    NIH/NHLBI
    Enhancing Inflammation Resolution in Atherosclerosis via Targeted Nanoparticle-Mediated Delivery of Biologics
    Role: Principal Investigator
  2. R01EB015419 (FAROKHZAD, OMID C) Apr 15, 2012 - Mar 31, 2016
    NIH/NIBIB
    Development of FcRn-Targeted Nanoparticles for Efficient Oral Delivery of Insulin
    Role: Principal Investigator
  3. K08EB003647 (FAROKHZAD, OMID C) Mar 1, 2005 - Mar 30, 2011
    NIH/NIBIB
    Development of Disease-Specific Drug Delivery Vehicles
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Xu X, Wu J, Liu S, Saw PE, Tao W, Li Y, Krygsman L, Yegnasubramanian S, De Marzo AM, Shi J, Bieberich CJ, Farokhzad OC. Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy. Small. 2018 Sep 17; e1802565. PMID: 30230235.
    View in: PubMed
  2. Tao W, Ji X, Zhu X, Li L, Wang J, Zhang Y, Saw PE, Li W, Kong N, Islam MA, Gan T, Zeng X, Zhang H, Mahmoudi M, Tearney GJ, Farokhzad OC. Two-Dimensional Antimonene-Based Photonic Nanomedicine for Cancer Theranostics. Adv Mater. 2018 Sep; 30(38):e1802061. PMID: 30043416.
    View in: PubMed
  3. Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, Lippard SJ, Farokhzad OC, Shi J, Wu J. Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance. Nano Lett. 2018 Jul 11; 18(7):4618-4625. PMID: 29902013.
    View in: PubMed
  4. Parak WJ, Chan WWC, Chhowalla M, Farokhzad O, Glotzer S, Gogotsi Y, Hammond PT, Hersam MC, Javey A, Kagan CR, Kataoka K, Khademhosseini A, Kotov NA, Lee ST, Lee YH, Li Y, Millstone J, Mulvaney PA, Nel AE, Nordlander PJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee ATS, Willson CG, Weiss PS. Helmuth Möhwald (1946-2018). ACS Nano. 2018 Apr 24; 12(4):3053-3055. PMID: 29676563.
    View in: PubMed
  5. Zhu X, Ji X, Kong N, Chen Y, Mahmoudi M, Xu X, Ding L, Tao W, Cai T, Li Y, Gan T, Barrett A, Bharwani Z, Chen H, Farokhzad OC. Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy. ACS Nano. 2018 Mar 27; 12(3):2922-2938. PMID: 29406760.
    View in: PubMed
  6. Zheng M, Tao W, Zou Y, Farokhzad OC, Shi B. Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy. Trends Biotechnol. 2018 May; 36(5):562-575. PMID: 29422412.
    View in: PubMed
  7. Chan WWC, Chhowalla M, Farokhzad O, Glotzer S, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kataoka K, Khademhosseini A, Kotov NA, Lee ST, Li Y, Millstone J, Möhwald H, Mulvaney PC, Nel AE, Nordlander PJ, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee ATS, Willson CG, Fernandez LE, Weiss PS. A Big Year Ahead for Nano in 2018. ACS Nano. 2017 Dec 26; 11(12):11755-11757. PMID: 29294604.
    View in: PubMed
  8. Bertrand N, Grenier P, Mahmoudi M, Lima EM, Appel EA, Dormont F, Lim JM, Karnik R, Langer R, Farokhzad OC. Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics. Nat Commun. 2017 10 03; 8(1):777. PMID: 28974673.
    View in: PubMed
  9. Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Multiscale technologies for treatment of ischemic cardiomyopathy. Nat Nanotechnol. 2017 Sep 06; 12(9):845-855. PMID: 28875984.
    View in: PubMed
  10. Wang J, Tao W, Chen X, Farokhzad OC, Liu G. Emerging Advances in Nanotheranostics with Intelligent Bioresponsive Systems. Theranostics. 2017; 7(16):3915-3919. PMID: 29109787.
    View in: PubMed
  11. Behzadi S, Luther GA, Harris MB, Farokhzad OC, Mahmoudi M. Nanomedicine for safe healing of bone trauma: Opportunities and challenges. Biomaterials. 2017 Nov; 146:168-182. PMID: 28918266.
    View in: PubMed
  12. Yu M, Amengual J, Menon A, Kamaly N, Zhou F, Xu X, Saw PE, Lee SJ, Si K, Ortega CA, Choi WI, Lee IH, Bdour Y, Shi J, Mahmoudi M, Jon S, Fisher EA, Farokhzad OC. Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr-/- Mice. Adv Healthc Mater. 2017 Oct; 6(20). PMID: 28730752.
    View in: PubMed
  13. Behzadi S, Serpooshan V, Tao W, Hamaly MA, Alkawareek MY, Dreaden EC, Brown D, Alkilany AM, Farokhzad OC, Mahmoudi M. Cellular uptake of nanoparticles: journey inside the cell. Chem Soc Rev. 2017 Jul 17; 46(14):4218-4244. PMID: 28585944.
    View in: PubMed
  14. Tao W, Ji X, Xu X, Islam MA, Li Z, Chen S, Saw PE, Zhang H, Bharwani Z, Guo Z, Shi J, Farokhzad OC. Antimonene Quantum Dots: Synthesis and Application as Near-Infrared Photothermal Agents for Effective Cancer Therapy. Angew Chem Int Ed Engl. 2017 Sep 18; 56(39):11896-11900. PMID: 28640986.
    View in: PubMed
  15. Shi B, Zheng M, Tao W, Chung R, Jin D, Ghaffari D, Farokhzad OC. Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery Systems. Biomacromolecules. 2017 Aug 14; 18(8):2231-2246. PMID: 28661127.
    View in: PubMed
  16. Xu X, Saw PE, Tao W, Li Y, Ji X, Bhasin S, Liu Y, Ayyash D, Rasmussen J, Huo M, Shi J, Farokhzad OC. ROS-Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy. Adv Mater. 2017 Sep; 29(33). PMID: 28681981.
    View in: PubMed
  17. Xu X, Saw PE, Tao W, Li Y, Ji X, Yu M, Mahmoudi M, Rasmussen J, Ayyash D, Zhou Y, Farokhzad OC, Shi J. Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy. Nano Lett. 2017 07 12; 17(7):4427-4435. PMID: 28636389.
    View in: PubMed
  18. Zhu X, Tao W, Liu D, Wu J, Guo Z, Ji X, Bharwani Z, Zhao L, Zhao X, Farokhzad OC, Shi J. Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo. Theranostics. 2017; 7(7):1990-2002. PMID: 28638484.
    View in: PubMed
  19. Chopra S, Bertrand N, Lim JM, Wang A, Farokhzad OC, Karnik R. Design of Insulin-Loaded Nanoparticles Enabled by Multistep Control of Nanoprecipitation and Zinc Chelation. ACS Appl Mater Interfaces. 2017 Apr 05; 9(13):11440-11450. PMID: 28323414.
    View in: PubMed
  20. Xu X, Wu J, Liu Y, Saw PE, Tao W, Yu M, Zope H, Si M, Victorious A, Rasmussen J, Ayyash D, Farokhzad OC, Shi J. Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy. ACS Nano. 2017 03 28; 11(3):2618-2627. PMID: 28240870.
    View in: PubMed
  21. Corbo C, Molinaro R, Tabatabaei M, Farokhzad OC, Mahmoudi M. Personalized protein corona on nanoparticles and its clinical implications. Biomater Sci. 2017 Feb 28; 5(3):378-387. PMID: 28133653.
    View in: PubMed
  22. Khademhosseini A, Chan WW, Chhowalla M, Glotzer SC, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kotov NA, Lee ST, Li Y, Möhwald H, Mulvaney PA, Nel AE, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee AT, Brinker J, Chen X, Chi L, Crommie M, Dekker C, Farokhzad O, Gerber C, Ginger DS, Irvine DJ, Kiessling LL, Kostarelos K, Landes C, Lee T, Leggett GJ, Liang XJ, Liz-Marzán L, Millstone J, Odom TW, Ozcan A, Prato M, Rao CN, Sailor MJ, Weiss E, Weiss PS. Nanoscience and Nanotechnology Cross Borders. ACS Nano. 2017 02 28; 11(2):1123-1126. PMID: 28199099.
    View in: PubMed
  23. Saw PE, Yu M, Choi M, Lee E, Jon S, Farokhzad OC. Hyper-cell-permeable micelles as a drug delivery carrier for effective cancer therapy. Biomaterials. 2017 04; 123:118-126. PMID: 28167390.
    View in: PubMed
  24. Shi J, Kantoff PW, Wooster R, Farokhzad OC. Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer. 2017 01; 17(1):20-37. PMID: 27834398.
    View in: PubMed
  25. Kamaly N, He JC, Ausiello DA, Farokhzad OC. Nanomedicines for renal disease: current status and future applications. Nat Rev Nephrol. 2016 Dec; 12(12):738-753. PMID: 27795549.
    View in: PubMed
  26. Saw PE, Park J, Jon S, Farokhzad OC. A drug-delivery strategy for overcoming drug resistance in breast cancer through targeting of oncofetal fibronectin. Nanomedicine. 2017 02; 13(2):713-722. PMID: 27769887.
    View in: PubMed
  27. Caracciolo G, Farokhzad OC, Mahmoudi M. Biological Identity of Nanoparticles In Vivo: Clinical Implications of the Protein Corona. Trends Biotechnol. 2017 03; 35(3):257-264. PMID: 27663778.
    View in: PubMed
  28. Cisterna BA, Kamaly N, Choi WI, Tavakkoli A, Farokhzad OC, Vilos C. Targeted nanoparticles for colorectal cancer. Nanomedicine (Lond). 2016 Sep; 11(18):2443-56. PMID: 27529192.
    View in: PubMed
  29. Liu Y, Gunda V, Zhu X, Xu X, Wu J, Askhatova D, Farokhzad OC, Parangi S, Shi J. Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7750-5. PMID: 27342857; PMCID: PMC4948349 [Available on 01/12/17].
    View in: PubMed, PubMed Central
  30. Xu X, Wu J, Liu Y, Yu M, Zhao L, Zhu X, Bhasin S, Li Q, Ha E, Shi J, Farokhzad OC. Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy. Angew Chem Int Ed Engl. 2016 06 13; 55(25):7091-7094. PMID: 27140428.
    View in: PubMed
  31. Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R. Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):5552-7. PMID: 27140638; PMCID: PMC4878518 [Available on 11/17/16].
    View in: PubMed, PubMed Central
  32. Kamaly N, Fredman G, Fojas JJ, Subramanian M, Choi WI, Zepeda K, Vilos C, Yu M, Gadde S, Wu J, Milton J, Carvalho Leitao R, Rosa Fernandes L, Hasan M, Gao H, Nguyen V, Harris J, Tabas I, Farokhzad OC. Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis. ACS Nano. 2016 05 24; 10(5):5280-92. PMID: 27100066.
    View in: PubMed
  33. Kamaly N, Yameen B, Wu J, Farokhzad OC. Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release. Chem Rev. 2016 Feb 24; 116(4):2602-63. PMID: 26854975.
    View in: PubMed
  34. Zhu X, Wu J, Shan W, Tao W, Zhao L, Lim JM, D'Ortenzio M, Karnik R, Huang Y, Shi J, Farokhzad OC. Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins. Angew Chem Int Ed Engl. 2016 Mar 01; 55(10):3309-12. PMID: 26846161; PMCID: PMC4835185 [Available on 03/01/17].
    View in: PubMed, PubMed Central
  35. Chung BL, Toth MJ, Kamaly N, Sei YJ, Becraft J, Mulder WJ, Fayad ZA, Farokhzad OC, Kim Y, Langer R. Nanomedicines for Endothelial Disorders. Nano Today. 2015 Dec 01; 10(6):759-776. PMID: 26955397.
    View in: PubMed
  36. Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R. Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Sci Transl Med. 2015 Nov 18; 7(314):314ra183. PMID: 26582898.
    View in: PubMed
  37. Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R. Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Nat Commun. 2015 Oct 27; 6:8692. PMID: 26503691; PMCID: PMC4711745.
    View in: PubMed, PubMed Central
  38. Yu M, Wu J, Shi J, Farokhzad OC. Nanotechnology for protein delivery: Overview and perspectives. J Control Release. 2016 10 28; 240:24-37. PMID: 26458789.
    View in: PubMed
  39. Farokhzad OC. Nanotechnology: Platelet mimicry. Nature. 2015 Oct 01; 526(7571):47-8. PMID: 26375011.
    View in: PubMed
  40. Yameen B, Vilos C, Choi WI, Whyte A, Huang J, Pollit L, Farokhzad OC. Drug Delivery Nanocarriers from a Fully Degradable PEG-Conjugated Polyester with a Reduction-Responsive Backbone. Chemistry. 2015 Aug 03; 21(32):11325-9. PMID: 26177931.
    View in: PubMed
  41. Wu J, Zhao L, Xu X, Bertrand N, Choi WI, Yameen B, Shi J, Shah V, Mulvale M, MacLean JL, Farokhzad OC. Hydrophobic Cysteine Poly(disulfide)-based Redox-Hypersensitive Nanoparticle Platform for Cancer Theranostics. Angew Chem Int Ed Engl. 2015 Aug 03; 54(32):9218-23. PMID: 26119453.
    View in: PubMed
  42. Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH. VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science. 2015 Jun 19; 348(6241):aaa8205. PMID: 26089520; PMCID: PMC4605428.
    View in: PubMed, PubMed Central
  43. Zhu X, Xu Y, Solis LM, Tao W, Wang L, Behrens C, Xu X, Zhao L, Liu D, Wu J, Zhang N, Wistuba II, Farokhzad OC, Zetter BR, Shi J. Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7779-84. PMID: 26056316.
    View in: PubMed
  44. Saw PE, Park J, Lee E, Ahn S, Lee J, Kim H, Kim J, Choi M, Farokhzad OC, Jon S. Effect of PEG pairing on the efficiency of cancer-targeting liposomes. Theranostics. 2015; 5(7):746-54. PMID: 25897339; PMCID: PMC4402498.
    View in: PubMed, PubMed Central
  45. Pridgen EM, Alexis F, Farokhzad OC. Polymeric nanoparticle drug delivery technologies for oral delivery applications. Expert Opin Drug Deliv. 2015; 12(9):1459-73. PMID: 25813361; PMCID: PMC4835173.
    View in: PubMed, PubMed Central
  46. Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perretti M, Farokzhad O, Tabas I. Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci Transl Med. 2015 Feb 18; 7(275):275ra20. PMID: 25695999.
    View in: PubMed
  47. Leoni G, Neumann PA, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS, Nusrat A. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest. 2015 Mar 02; 125(3):1215-27. PMID: 25664854; PMCID: PMC4362251.
    View in: PubMed, PubMed Central
  48. Xu X, Ho W, Zhang X, Bertrand N, Farokhzad O. Cancer nanomedicine: from targeted delivery to combination therapy. Trends Mol Med. 2015 Apr; 21(4):223-32. PMID: 25656384; PMCID: PMC4385479.
    View in: PubMed, PubMed Central
  49. Maldonado RA, LaMothe RA, Ferrari JD, Zhang AH, Rossi RJ, Kolte PN, Griset AP, O'Neil C, Altreuter DH, Browning E, Johnston L, Farokhzad OC, Langer R, Scott DW, von Andrian UH, Kishimoto TK. Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):E156-65. PMID: 25548186; PMCID: PMC4299193.
    View in: PubMed, PubMed Central
  50. Choi WI, Kamaly N, Riol-Blanco L, Lee IH, Wu J, Swami A, Vilos C, Yameen B, Yu M, Shi J, Tabas I, von Andrian UH, Jon S, Farokhzad OC. A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins. Nano Lett. 2014 Nov 12; 14(11):6449-55. PMID: 25333768; PMCID: PMC4245989.
    View in: PubMed, PubMed Central
  51. Zhang XQ, Even-Or O, Xu X, van Rosmalen M, Lim L, Gadde S, Farokhzad OC, Fisher EA. Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis. Adv Healthc Mater. 2015 Jan 28; 4(2):228-36. PMID: 25156796; PMCID: PMC4527680.
    View in: PubMed, PubMed Central
  52. Wu J, Kamaly N, Shi J, Zhao L, Xiao Z, Hollett G, John R, Ray S, Xu X, Zhang X, Kantoff PW, Farokhzad OC. Development of multinuclear polymeric nanoparticles as robust protein nanocarriers. Angew Chem Int Ed Engl. 2014 Aug 18; 53(34):8975-9. PMID: 24990548; PMCID: PMC4143165.
    View in: PubMed, PubMed Central
  53. Swami A, Reagan MR, Basto P, Mishima Y, Kamaly N, Glavey S, Zhang S, Moschetta M, Seevaratnam D, Zhang Y, Liu J, Memarzadeh M, Wu J, Manier S, Shi J, Bertrand N, Lu ZN, Nagano K, Baron R, Sacco A, Roccaro AM, Farokhzad OC, Ghobrial IM. Engineered nanomedicine for myeloma and bone microenvironment targeting. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10287-92. PMID: 24982170; PMCID: PMC4104924.
    View in: PubMed, PubMed Central
  54. Yameen B, Choi WI, Vilos C, Swami A, Shi J, Farokhzad OC. Insight into nanoparticle cellular uptake and intracellular targeting. J Control Release. 2014 Sep 28; 190:485-99. PMID: 24984011; PMCID: PMC4153400.
    View in: PubMed, PubMed Central
  55. Pridgen EM, Alexis F, Farokhzad OC. Polymeric nanoparticle technologies for oral drug delivery. Clin Gastroenterol Hepatol. 2014 Oct; 12(10):1605-10. PMID: 24981782.
    View in: PubMed
  56. Lim JM, Swami A, Gilson LM, Chopra S, Choi S, Wu J, Langer R, Karnik R, Farokhzad OC. Ultra-high throughput synthesis of nanoparticles with homogeneous size distribution using a coaxial turbulent jet mixer. ACS Nano. 2014 Jun 24; 8(6):6056-65. PMID: 24824296; PMCID: PMC4072409.
    View in: PubMed, PubMed Central
  57. Gadde S, Even-Or O, Kamaly N, Hasija A, Gagnon PG, Adusumilli KH, Erakovic A, Pal AK, Zhang XQ, Kolishetti N, Shi J, Fisher EA, Farokhzad OC. Development of therapeutic polymeric nanoparticles for the resolution of inflammation. Adv Healthc Mater. 2014 Sep; 3(9):1448-1456. PMID: 24659608; PMCID: PMC4160375.
    View in: PubMed, PubMed Central
  58. Shi J, Xu Y, Xu X, Zhu X, Pridgen E, Wu J, Votruba AR, Swami A, Zetter BR, Farokhzad OC. Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing. Nanomedicine. 2014 Jul; 10(5):897-900. PMID: 24650883; PMCID: PMC4077924.
    View in: PubMed, PubMed Central
  59. Gendelman HE, Balogh LP, Bawa R, Bradbury M, Chang EH, Chiu W, Farokhzad O, Foldvari M, Lanza G, Wang K. The 4th Annual Meeting of the American Society for Nanomedicine. J Neuroimmune Pharmacol. 2014 Mar; 9 Suppl 1:S1-3. PMID: 24550132.
    View in: PubMed
  60. Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK. Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine. 2014 May 19; 32(24):2882-95. PMID: 24593999; PMCID: PMC4059049.
    View in: PubMed, PubMed Central
  61. Wang AZ, Farokhzad OC. Current progress of aptamer-based molecular imaging. J Nucl Med. 2014 Mar; 55(3):353-6. PMID: 24525205; PMCID: PMC4110511.
    View in: PubMed, PubMed Central
  62. Kim Y, Lobatto ME, Kawahara T, Lee Chung B, Mieszawska AJ, Sanchez-Gaytan BL, Fay F, Senders ML, Calcagno C, Becraft J, Tun Saung M, Gordon RE, Stroes ES, Ma M, Farokhzad OC, Fayad ZA, Mulder WJ, Langer R. Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1078-83. PMID: 24395808; PMCID: PMC3903216.
    View in: PubMed, PubMed Central
  63. Pridgen EM, Alexis F, Kuo TT, Levy-Nissenbaum E, Karnik R, Blumberg RS, Langer R, Farokhzad OC. Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery. Sci Transl Med. 2013 Nov 27; 5(213):213ra167. PMID: 24285486; PMCID: PMC4023672.
    View in: PubMed, PubMed Central
  64. Bertrand N, Wu J, Xu X, Kamaly N, Farokhzad OC. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev. 2014 Feb; 66:2-25. PMID: 24270007; PMCID: PMC4219254.
    View in: PubMed, PubMed Central
  65. Valencia PM, Pridgen EM, Rhee M, Langer R, Farokhzad OC, Karnik R. Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy. ACS Nano. 2013 Dec 23; 7(12):10671-80. PMID: 24215426; PMCID: PMC3963607.
    View in: PubMed, PubMed Central
  66. Xu X, Xie K, Zhang XQ, Pridgen EM, Park GY, Cui DS, Shi J, Wu J, Kantoff PW, Lippard SJ, Langer R, Walker GC, Farokhzad OC. Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18638-43. PMID: 24167294; PMCID: PMC3832000.
    View in: PubMed, PubMed Central
  67. Gianella A, Mieszawska AJ, Hoeben FJ, Janssen HM, Jarzyna PA, Cormode DP, Costa KD, Rao S, Farokhzad OC, Langer R, Fayad ZA, Mulder WJ. Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform. Chem Commun (Camb). 2013 Oct 21; 49(82):9392-4. PMID: 23877789; PMCID: PMC3786364.
    View in: PubMed, PubMed Central
  68. Kim Y, Fay F, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy EJ, Ma M, Moore K, Farokhzad OC, Fisher EA, Mulder WJ, Langer R, Fayad ZA. Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics. ACS Nano. 2013 Nov 26; 7(11):9975-83. PMID: 24079940; PMCID: PMC4104519.
    View in: PubMed, PubMed Central
  69. Kim Y, Lee Chung B, Ma M, Mulder WJ, Fayad ZA, Farokhzad OC, Langer R. Correction to Mass Production and Size Control of Lipid-Polymer Hybrid Nanoparticles through Controlled Microvortices. Nano Lett. 2013 Oct 9; 13(10):4997. PMID: 24041197.
    View in: PubMed
  70. Mieszawska AJ, Kim Y, Gianella A, van Rooy I, Priem B, Labarre MP, Ozcan C, Cormode DP, Petrov A, Langer R, Farokhzad OC, Fayad ZA, Mulder WJ. Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy. Bioconjug Chem. 2013 Sep 18; 24(9):1429-34. PMID: 23957728; PMCID: PMC3810168.
    View in: PubMed, PubMed Central
  71. Lim JM, Bertrand N, Valencia PM, Rhee M, Langer R, Jon S, Farokhzad OC, Karnik R. Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study. Nanomedicine. 2014 Feb; 10(2):401-9. PMID: 23969105; PMCID: PMC3951970.
    View in: PubMed, PubMed Central
  72. Johnstone TC, Kulak N, Pridgen EM, Farokhzad OC, Langer R, Lippard SJ. Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties. ACS Nano. 2013 Jul 23; 7(7):5675-83. PMID: 23697579; PMCID: PMC3722263.
    View in: PubMed, PubMed Central
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  184. Radovic-Moreno AF, Fuller J, Nguyen DN, Langer R, Farokhzad OC. Nanotechnology: Delivering on the Promise of Nucleic Acid Therapeutics. Oligonucleotide. 2007; Invited Review (submitted).
  185. Jon SY, Farokhzad OC, Langer RS. Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals. 2007.
  186. Wang AZ, Bagalkot V, Gu F, Alexis F, Vasilliou C, Cima M, Jon S, Farokhzad OC. Novel targeted aptamer-superparamagnetic iron oxide nanoparticles bioconjugates for combined prostate cancer imaging and therapy. International Journal of Radiation Oncology*Biology*Physics. 2007; 69(3):S110-1.
  187. Gu FX, Karnik R, Wang AZ, Alexis F, Levy-Nissenbaum E, Hong S, Langer RS, Farokhzad OC. Targeted nanoparticles for cancer therapy. Nano Today. 2007; 2(3):14-21.
  188. Bagalvot V, Farokhzad OC, Langer R, Sangyong J. Aptamer-dox conjugates as novel platform for targeted drug delivery and imaging. Nanomedicine: Nanotechnology, Biology, and Medicine. 2007; 3(4):352.
  189. Farokhzad OC, Radovic-Morano A, Langer R. Systems for screening particles. 2006.
  190. Bagalkot V, Farokhzad OC, Langer R, Jon S. An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed Engl. 2006 Dec 11; 45(48):8149-52. PMID: 17099918.
    View in: PubMed
  191. Slocum A, Farokhzad OC. Drug Delivery Arterial Balloon With Blood Bypass. 2006.
  192. Farokhzad OC, Karp J, Slocum A, Langer R. A device for sensing tissues and tissue compartments. 2006.
  193. Farokhzad OC, Alexis F, Kuo T, Langer R. Receptor Triggered Controlled Drug Delivery Systems to Cross Endothelial and/or Epithelial Cell Layers and their Method of Preparation. 2006.
  194. Farokhzad OC, Langer R. Nanomedicine: developing smarter therapeutic and diagnostic modalities. Adv Drug Deliv Rev. 2006 Dec 01; 58(14):1456-9. PMID: 17070960.
    View in: PubMed
  195. Cheng J, Teply BA, Sherifi I, Sung J, Luther G, Gu FX, Levy-Nissenbaum E, Radovic-Moreno AF, Langer R, Farokhzad OC. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials. 2007 Feb; 28(5):869-76. PMID: 17055572; PMCID: PMC2925222.
    View in: PubMed, PubMed Central
  196. Cheng J, Farokhzad OC, Teply B and Langer RS. Magnetically-labeled microparticles for oral drug delivery. 2006.
  197. Farokhzad OC, Alexis F, Gu F, Radovic-Moreno A, Langer R. Affibodies as a Targeting Ligand in Controlled Drug Delivery Systems. 2006.
  198. Shelley CS and Farokhzad OC. Methods for Diagnosing and Treating Tumors and Suppressing CD Promoters. 2006.
  199. Teply BA, Rocha FG, Levy-Nissenbaum E, Langer R, Farokhzad OC. Nanoparticle-aptamer bioconjugates for targeted antineoplastic drug delivery. Am J Drug Del. 2006; 4(3):123-30.
  200. Farokhzad OC, Dimitrakov JD, Karp JM, Khademhosseini A, Freeman MR, Langer R. Drug delivery systems in urology--getting "smarter". Urology. 2006 Sep; 68(3):463-9. PMID: 17010721; PMCID: PMC1618825.
    View in: PubMed, PubMed Central
  201. Farokhzad OC, Karp JM, Langer R. Nanoparticle-aptamer bioconjugates for cancer targeting. Expert Opin Drug Deliv. 2006 May; 3(3):311-24. PMID: 16640493.
    View in: PubMed
  202. Farokhzad OC, Cheng J, Teply BA, Sherifi I, Jon S, Kantoff PW, Richie JP, Langer R. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6315-20. PMID: 16606824; PMCID: PMC1458875.
    View in: PubMed, PubMed Central
  203. Farokhzad OC, Khademhosseini A, Langer R. High throughput synthesis of functionalized materials. 2006.
  204. Farokhzad OC, Langer R. Method of identifying particles that target certain cells, tissues or organs. 2006.
  205. Cheng J, Teply BA, Jeong SY, Yim CH, Ho D, Sherifi I, Jon S, Farokhzad OC, Khademhosseini A, Langer RS. Magnetically responsive polymeric microparticles for oral delivery of protein drugs. Pharm Res. 2006 Mar; 23(3):557-64. PMID: 16388405.
    View in: PubMed
  206. Farokhzad OC, Cheng J, Teply B, Khademhosseini A, Jon S, Levy-Nissenbaum E, Langer R. Cancer nanotechnology: drug encapsulated nanoparticle-aptamer bioconjugates for targeted delivery to prostate cancer cells. Federation of European Cancer Societies. 2005.
  207. Fukuda J, Khademhosseini A, Yeh J, Eng G, Cheng J, Farokhzad OC, Langer R. Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components. Biomaterials. 2006 Mar; 27(8):1479-86. PMID: 16242769.
    View in: PubMed
  208. Khademhosseini A, Yeh J, Eng G, Karp J, Kaji H, Borenstein J, Farokhzad OC, Langer R. Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays. Lab Chip. 2005 Dec; 5(12):1380-6. PMID: 16286969.
    View in: PubMed
  209. Farokhzad OC, Khademhosseini A, Jon S, Hermmann A, Cheng J, Chin C, Kiselyuk A, Teply B, Eng G, Langer R. Microfluidic system for studying the interaction of nanoparticles and microparticles with cells. Anal Chem. 2005 Sep 01; 77(17):5453-9. PMID: 16131052.
    View in: PubMed
  210. Farokhzad OC, Jon SY and Langer RS. Targeted delivery of controlled release polymer systems. 2005.
  211. Cheng J, Farokhzad OC, Teply B and Langer RS. Magnetically-labeled microparticles for oral drug delivery. 2005.
  212. Farokhzad OC, Jon SY and Langer RS. Targeted delivery of controlled release polymer systems. 2005.
  213. Cheng J, Teply BA, Sherifi I, Khademhosseini A, Langer R, Farokhzad OC. PLGA nanoparticle-aptamer bioconjugate as drug delivery vehicles for targeted prostate cancer therapy. Third International Nanomedicine and Drug Delivery Symposium, Baltimore, MD. 2005.
  214. Farokhzad OC, Jon SY and Langer RS. Targeted delivery of controlled release polymer systems. 2004.
  215. Jon SY, Farokhzad OC and Langer RS. Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals. 2004.
  216. Farokhzad OC, Jon S, Khademhosseini A, Tran TN, Lavan DA, Langer R. Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res. 2004 Nov 01; 64(21):7668-72. PMID: 15520166.
    View in: PubMed
  217. Shelley CS and Farokhzad OC. Method of treating tumors and suppressing CD promoters. 2004.
  218. Farokhzad OC, Jon SY and Langer RS. Targeted delivery of controlled release polymer systems. 2003.
  219. Nicolaou F, Teodoridis JM, Park H, Georgakis A, Farokhzad OC, Böttinger EP, Da Silva N, Rousselot P, Chomienne C, Ferenczi K, Arnaout MA, Shelley CS. CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD. Blood. 2003 May 15; 101(10):4033-41. PMID: 12576324.
    View in: PubMed
  220. Shelley CS, Teodoridis JM, Park H, Farokhzad OC, Böttinger EP, Arnaout MA. During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter. J Immunol. 2002 Apr 15; 168(8):3887-93. PMID: 11937543.
    View in: PubMed
  221. Song JC, Hanson CM, Tsai V, Farokhzad OC, Lotz M, Matthews JB. Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C649-61. PMID: 11443064.
    View in: PubMed
  222. Farokhzad OC, Teodoridis JM, Park H, Arnaout MA, Shelley CS. CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA. Nucleic Acids Res. 2000 Jun 01; 28(11):2256-67. PMID: 10871347; PMCID: PMC102628.
    View in: PubMed, PubMed Central
  223. Kyei-Aboagye K, Kasznica J, Pomeroy O, Farokhzad OC, and Noel J. . Double uterus with unilateral cervical dysgenesis and ipsilateral renal agenesis. Journal of Pelvic Surgery. 2000; 6:98-101.
  224. Farokhzad OC, Sagar GD, Mun EC, Sicklick JK, Lotz M, Smith JA, Song JC, O'Brien TC, Sharma CP, Kinane TB, Hodin RA, Matthews JB. Protein kinase C activation downregulates the expression and function of the basolateral Na+/K+/2Cl(-) cotransporter. J Cell Physiol. 1999 Dec; 181(3):489-98. PMID: 10528235.
    View in: PubMed
  225. Song JC, Hrnjez BJ, Farokhzad OC, Matthews JB. PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS. Am J Physiol. 1999 12; 277(6):C1239-49. PMID: 10600776.
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  226. Sagar V. Song JC, Farokhzad OC, and Matthews JB. Regulation of NICC1 surface expression by Protein Kinase C. Gastroenterology. 1999; 116:G4021.
  227. Farokhzad OC, Mun EC, Sicklick JK, Smith JA, Matthews JB. Effects of bryostatin 1, a novel anticancer agent, on intestinal transport and barrier function: role of protein kinase C. Surgery. 1998 Aug; 124(2):380-6; discussion 386-7. PMID: 9706162.
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  228. Mun EC, Mayol JM, Riegler M, O'Brien TC, Farokhzad OC, Song JC, Pothoulakis C, Hrnjez BJ, Matthews JB. Levamisole inhibits intestinal Cl- secretion via basolateral K+ channel blockade. Gastroenterology. 1998 Jun; 114(6):1257-67. PMID: 9609763.
    View in: PubMed
  229. Farokhzad OC, Shelley CS, Arnaout MA. Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2. J Immunol. 1996 Dec 15; 157(12):5597-605. PMID: 8955212.
    View in: PubMed
  230. Böttinger EP, Shelley CS, Farokhzad OC, Arnaout MA. The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements. Mol Cell Biol. 1994 Apr; 14(4):2604-15. PMID: 7511209; PMCID: PMC358628.
    View in: PubMed, PubMed Central
  231. Bottinger EP, Factor V, Tsang ML-S, Weatherbee JA, Qian S, Farokhzad OC, Wakefield LM, Thorgeirsson SS, Kopp JB, Roberts AB, and Sporn MB. The recombinant proregion of transforming growth factor beta1 modulates its activity in-vitro and in-vivo. Journal of the American Society of Nephrology. 1994; 5:689.
  232. Shelley CS, Farokhzad OC, Arnaout MA. Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5364-8. PMID: 8099450; PMCID: PMC46717.
    View in: PubMed, PubMed Central
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©2018 President and Fellows of Harvard College
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.