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Omid Cameron Farokhzad, M.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
Development of Targeted Nanoparticle to Facilitate Drug Delivery for Treating Atherosclerois
Summer, 06/25/07 - 08/17/07

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL127464 (TABAS, IRA A) Jan 1, 2016 - Dec 31, 2019
    NIH/NHLBI
    Enhancing Inflammation Resolution in Atherosclerosis via Targeted Nanoparticle-Mediated Delivery of Biologics
    Role: Principal Investigator
  2. R01EB015419 (FAROKHZAD, OMID C) Apr 15, 2012 - Mar 31, 2016
    NIH/NIBIB
    Development of FcRn-Targeted Nanoparticles for Efficient Oral Delivery of Insulin
    Role: Principal Investigator
  3. K08EB003647 (FAROKHZAD, OMID C) Mar 1, 2005 - Mar 30, 2011
    NIH/NIBIB
    Development of Disease-Specific Drug Delivery Vehicles
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Xu X, Wu J, Liu S, Saw PE, Tao W, Li Y, Krygsman L, Yegnasubramanian S, De Marzo AM, Shi J, Bieberich CJ, Farokhzad OC. Redox-Responsive Nanoparticle-Mediated Systemic RNAi for Effective Cancer Therapy. Small. 2018 Sep 17; e1802565. PMID: 30230235.
    View in: PubMed
  2. Tao W, Ji X, Zhu X, Li L, Wang J, Zhang Y, Saw PE, Li W, Kong N, Islam MA, Gan T, Zeng X, Zhang H, Mahmoudi M, Tearney GJ, Farokhzad OC. Two-Dimensional Antimonene-Based Photonic Nanomedicine for Cancer Theranostics. Adv Mater. 2018 Sep; 30(38):e1802061. PMID: 30043416.
    View in: PubMed
  3. Ling X, Chen X, Riddell IA, Tao W, Wang J, Hollett G, Lippard SJ, Farokhzad OC, Shi J, Wu J. Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance. Nano Lett. 2018 Jul 11; 18(7):4618-4625. PMID: 29902013.
    View in: PubMed
  4. Parak WJ, Chan WWC, Chhowalla M, Farokhzad O, Glotzer S, Gogotsi Y, Hammond PT, Hersam MC, Javey A, Kagan CR, Kataoka K, Khademhosseini A, Kotov NA, Lee ST, Lee YH, Li Y, Millstone J, Mulvaney PA, Nel AE, Nordlander PJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee ATS, Willson CG, Weiss PS. Helmuth Möhwald (1946-2018). ACS Nano. 2018 Apr 24; 12(4):3053-3055. PMID: 29676563.
    View in: PubMed
  5. Zhu X, Ji X, Kong N, Chen Y, Mahmoudi M, Xu X, Ding L, Tao W, Cai T, Li Y, Gan T, Barrett A, Bharwani Z, Chen H, Farokhzad OC. Intracellular Mechanistic Understanding of 2D MoS2 Nanosheets for Anti-Exocytosis-Enhanced Synergistic Cancer Therapy. ACS Nano. 2018 Mar 27; 12(3):2922-2938. PMID: 29406760.
    View in: PubMed
  6. Zheng M, Tao W, Zou Y, Farokhzad OC, Shi B. Nanotechnology-Based Strategies for siRNA Brain Delivery for Disease Therapy. Trends Biotechnol. 2018 May; 36(5):562-575. PMID: 29422412.
    View in: PubMed
  7. Chan WWC, Chhowalla M, Farokhzad O, Glotzer S, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kataoka K, Khademhosseini A, Kotov NA, Lee ST, Li Y, Millstone J, Möhwald H, Mulvaney PC, Nel AE, Nordlander PJ, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee ATS, Willson CG, Fernandez LE, Weiss PS. A Big Year Ahead for Nano in 2018. ACS Nano. 2017 Dec 26; 11(12):11755-11757. PMID: 29294604.
    View in: PubMed
  8. Bertrand N, Grenier P, Mahmoudi M, Lima EM, Appel EA, Dormont F, Lim JM, Karnik R, Langer R, Farokhzad OC. Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics. Nat Commun. 2017 10 03; 8(1):777. PMID: 28974673.
    View in: PubMed
  9. Mahmoudi M, Yu M, Serpooshan V, Wu JC, Langer R, Lee RT, Karp JM, Farokhzad OC. Multiscale technologies for treatment of ischemic cardiomyopathy. Nat Nanotechnol. 2017 Sep 06; 12(9):845-855. PMID: 28875984.
    View in: PubMed
  10. Wang J, Tao W, Chen X, Farokhzad OC, Liu G. Emerging Advances in Nanotheranostics with Intelligent Bioresponsive Systems. Theranostics. 2017; 7(16):3915-3919. PMID: 29109787.
    View in: PubMed
  11. Behzadi S, Luther GA, Harris MB, Farokhzad OC, Mahmoudi M. Nanomedicine for safe healing of bone trauma: Opportunities and challenges. Biomaterials. 2017 Nov; 146:168-182. PMID: 28918266.
    View in: PubMed
  12. Yu M, Amengual J, Menon A, Kamaly N, Zhou F, Xu X, Saw PE, Lee SJ, Si K, Ortega CA, Choi WI, Lee IH, Bdour Y, Shi J, Mahmoudi M, Jon S, Fisher EA, Farokhzad OC. Targeted Nanotherapeutics Encapsulating Liver X Receptor Agonist GW3965 Enhance Antiatherogenic Effects without Adverse Effects on Hepatic Lipid Metabolism in Ldlr-/- Mice. Adv Healthc Mater. 2017 Oct; 6(20). PMID: 28730752.
    View in: PubMed
  13. Behzadi S, Serpooshan V, Tao W, Hamaly MA, Alkawareek MY, Dreaden EC, Brown D, Alkilany AM, Farokhzad OC, Mahmoudi M. Cellular uptake of nanoparticles: journey inside the cell. Chem Soc Rev. 2017 Jul 17; 46(14):4218-4244. PMID: 28585944.
    View in: PubMed
  14. Tao W, Ji X, Xu X, Islam MA, Li Z, Chen S, Saw PE, Zhang H, Bharwani Z, Guo Z, Shi J, Farokhzad OC. Antimonene Quantum Dots: Synthesis and Application as Near-Infrared Photothermal Agents for Effective Cancer Therapy. Angew Chem Int Ed Engl. 2017 Sep 18; 56(39):11896-11900. PMID: 28640986.
    View in: PubMed
  15. Shi B, Zheng M, Tao W, Chung R, Jin D, Ghaffari D, Farokhzad OC. Challenges in DNA Delivery and Recent Advances in Multifunctional Polymeric DNA Delivery Systems. Biomacromolecules. 2017 Aug 14; 18(8):2231-2246. PMID: 28661127.
    View in: PubMed
  16. Xu X, Saw PE, Tao W, Li Y, Ji X, Bhasin S, Liu Y, Ayyash D, Rasmussen J, Huo M, Shi J, Farokhzad OC. ROS-Responsive Polyprodrug Nanoparticles for Triggered Drug Delivery and Effective Cancer Therapy. Adv Mater. 2017 Sep; 29(33). PMID: 28681981.
    View in: PubMed
  17. Xu X, Saw PE, Tao W, Li Y, Ji X, Yu M, Mahmoudi M, Rasmussen J, Ayyash D, Zhou Y, Farokhzad OC, Shi J. Tumor Microenvironment-Responsive Multistaged Nanoplatform for Systemic RNAi and Cancer Therapy. Nano Lett. 2017 07 12; 17(7):4427-4435. PMID: 28636389.
    View in: PubMed
  18. Zhu X, Tao W, Liu D, Wu J, Guo Z, Ji X, Bharwani Z, Zhao L, Zhao X, Farokhzad OC, Shi J. Surface De-PEGylation Controls Nanoparticle-Mediated siRNA Delivery In Vitro and In Vivo. Theranostics. 2017; 7(7):1990-2002. PMID: 28638484.
    View in: PubMed
  19. Chopra S, Bertrand N, Lim JM, Wang A, Farokhzad OC, Karnik R. Design of Insulin-Loaded Nanoparticles Enabled by Multistep Control of Nanoprecipitation and Zinc Chelation. ACS Appl Mater Interfaces. 2017 Apr 05; 9(13):11440-11450. PMID: 28323414.
    View in: PubMed
  20. Xu X, Wu J, Liu Y, Saw PE, Tao W, Yu M, Zope H, Si M, Victorious A, Rasmussen J, Ayyash D, Farokhzad OC, Shi J. Multifunctional Envelope-Type siRNA Delivery Nanoparticle Platform for Prostate Cancer Therapy. ACS Nano. 2017 03 28; 11(3):2618-2627. PMID: 28240870.
    View in: PubMed
  21. Corbo C, Molinaro R, Tabatabaei M, Farokhzad OC, Mahmoudi M. Personalized protein corona on nanoparticles and its clinical implications. Biomater Sci. 2017 Feb 28; 5(3):378-387. PMID: 28133653.
    View in: PubMed
  22. Khademhosseini A, Chan WW, Chhowalla M, Glotzer SC, Gogotsi Y, Hafner JH, Hammond PT, Hersam MC, Javey A, Kagan CR, Kotov NA, Lee ST, Li Y, Möhwald H, Mulvaney PA, Nel AE, Parak WJ, Penner RM, Rogach AL, Schaak RE, Stevens MM, Wee AT, Brinker J, Chen X, Chi L, Crommie M, Dekker C, Farokhzad O, Gerber C, Ginger DS, Irvine DJ, Kiessling LL, Kostarelos K, Landes C, Lee T, Leggett GJ, Liang XJ, Liz-Marzán L, Millstone J, Odom TW, Ozcan A, Prato M, Rao CN, Sailor MJ, Weiss E, Weiss PS. Nanoscience and Nanotechnology Cross Borders. ACS Nano. 2017 02 28; 11(2):1123-1126. PMID: 28199099.
    View in: PubMed
  23. Saw PE, Yu M, Choi M, Lee E, Jon S, Farokhzad OC. Hyper-cell-permeable micelles as a drug delivery carrier for effective cancer therapy. Biomaterials. 2017 04; 123:118-126. PMID: 28167390.
    View in: PubMed
  24. Shi J, Kantoff PW, Wooster R, Farokhzad OC. Cancer nanomedicine: progress, challenges and opportunities. Nat Rev Cancer. 2017 01; 17(1):20-37. PMID: 27834398.
    View in: PubMed
  25. Kamaly N, He JC, Ausiello DA, Farokhzad OC. Nanomedicines for renal disease: current status and future applications. Nat Rev Nephrol. 2016 Dec; 12(12):738-753. PMID: 27795549.
    View in: PubMed
  26. Saw PE, Park J, Jon S, Farokhzad OC. A drug-delivery strategy for overcoming drug resistance in breast cancer through targeting of oncofetal fibronectin. Nanomedicine. 2017 02; 13(2):713-722. PMID: 27769887.
    View in: PubMed
  27. Caracciolo G, Farokhzad OC, Mahmoudi M. Biological Identity of Nanoparticles In Vivo: Clinical Implications of the Protein Corona. Trends Biotechnol. 2017 03; 35(3):257-264. PMID: 27663778.
    View in: PubMed
  28. Cisterna BA, Kamaly N, Choi WI, Tavakkoli A, Farokhzad OC, Vilos C. Targeted nanoparticles for colorectal cancer. Nanomedicine (Lond). 2016 Sep; 11(18):2443-56. PMID: 27529192.
    View in: PubMed
  29. Liu Y, Gunda V, Zhu X, Xu X, Wu J, Askhatova D, Farokhzad OC, Parangi S, Shi J. Theranostic near-infrared fluorescent nanoplatform for imaging and systemic siRNA delivery to metastatic anaplastic thyroid cancer. Proc Natl Acad Sci U S A. 2016 07 12; 113(28):7750-5. PMID: 27342857; PMCID: PMC4948349 [Available on 01/12/17].
  30. Xu X, Wu J, Liu Y, Yu M, Zhao L, Zhu X, Bhasin S, Li Q, Ha E, Shi J, Farokhzad OC. Ultra-pH-Responsive and Tumor-Penetrating Nanoplatform for Targeted siRNA Delivery with Robust Anti-Cancer Efficacy. Angew Chem Int Ed Engl. 2016 06 13; 55(25):7091-7094. PMID: 27140428.
    View in: PubMed
  31. Xue Y, Xu X, Zhang XQ, Farokhzad OC, Langer R. Preventing diet-induced obesity in mice by adipose tissue transformation and angiogenesis using targeted nanoparticles. Proc Natl Acad Sci U S A. 2016 May 17; 113(20):5552-7. PMID: 27140638; PMCID: PMC4878518 [Available on 11/17/16].
  32. Kamaly N, Fredman G, Fojas JJ, Subramanian M, Choi WI, Zepeda K, Vilos C, Yu M, Gadde S, Wu J, Milton J, Carvalho Leitao R, Rosa Fernandes L, Hasan M, Gao H, Nguyen V, Harris J, Tabas I, Farokhzad OC. Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis. ACS Nano. 2016 05 24; 10(5):5280-92. PMID: 27100066.
    View in: PubMed
  33. Kamaly N, Yameen B, Wu J, Farokhzad OC. Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release. Chem Rev. 2016 Feb 24; 116(4):2602-63. PMID: 26854975.
    View in: PubMed
  34. Zhu X, Wu J, Shan W, Tao W, Zhao L, Lim JM, D'Ortenzio M, Karnik R, Huang Y, Shi J, Farokhzad OC. Polymeric Nanoparticles Amenable to Simultaneous Installation of Exterior Targeting and Interior Therapeutic Proteins. Angew Chem Int Ed Engl. 2016 Mar 01; 55(10):3309-12. PMID: 26846161; PMCID: PMC4835185 [Available on 03/01/17].
  35. Chung BL, Toth MJ, Kamaly N, Sei YJ, Becraft J, Mulder WJ, Fayad ZA, Farokhzad OC, Kim Y, Langer R. Nanomedicines for Endothelial Disorders. Nano Today. 2015 Dec 01; 10(6):759-776. PMID: 26955397.
    View in: PubMed
  36. Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R. Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Sci Transl Med. 2015 Nov 18; 7(314):314ra183. PMID: 26582898.
    View in: PubMed
  37. Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R. Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Nat Commun. 2015 Oct 27; 6:8692. PMID: 26503691; PMCID: PMC4711745.
  38. Yu M, Wu J, Shi J, Farokhzad OC. Nanotechnology for protein delivery: Overview and perspectives. J Control Release. 2016 10 28; 240:24-37. PMID: 26458789.
    View in: PubMed
  39. Farokhzad OC. Nanotechnology: Platelet mimicry. Nature. 2015 Oct 01; 526(7571):47-8. PMID: 26375011.
    View in: PubMed
  40. Yameen B, Vilos C, Choi WI, Whyte A, Huang J, Pollit L, Farokhzad OC. Drug Delivery Nanocarriers from a Fully Degradable PEG-Conjugated Polyester with a Reduction-Responsive Backbone. Chemistry. 2015 Aug 03; 21(32):11325-9. PMID: 26177931.
    View in: PubMed
  41. Wu J, Zhao L, Xu X, Bertrand N, Choi WI, Yameen B, Shi J, Shah V, Mulvale M, MacLean JL, Farokhzad OC. Hydrophobic Cysteine Poly(disulfide)-based Redox-Hypersensitive Nanoparticle Platform for Cancer Theranostics. Angew Chem Int Ed Engl. 2015 Aug 03; 54(32):9218-23. PMID: 26119453.
    View in: PubMed
  42. Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH. VACCINES. A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science. 2015 Jun 19; 348(6241):aaa8205. PMID: 26089520; PMCID: PMC4605428.
  43. Zhu X, Xu Y, Solis LM, Tao W, Wang L, Behrens C, Xu X, Zhao L, Liu D, Wu J, Zhang N, Wistuba II, Farokhzad OC, Zetter BR, Shi J. Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7779-84. PMID: 26056316.
    View in: PubMed
  44. Saw PE, Park J, Lee E, Ahn S, Lee J, Kim H, Kim J, Choi M, Farokhzad OC, Jon S. Effect of PEG pairing on the efficiency of cancer-targeting liposomes. Theranostics. 2015; 5(7):746-54. PMID: 25897339; PMCID: PMC4402498.
  45. Pridgen EM, Alexis F, Farokhzad OC. Polymeric nanoparticle drug delivery technologies for oral delivery applications. Expert Opin Drug Deliv. 2015; 12(9):1459-73. PMID: 25813361; PMCID: PMC4835173.
  46. Fredman G, Kamaly N, Spolitu S, Milton J, Ghorpade D, Chiasson R, Kuriakose G, Perretti M, Farokzhad O, Tabas I. Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice. Sci Transl Med. 2015 Feb 18; 7(275):275ra20. PMID: 25695999.
    View in: PubMed
  47. Leoni G, Neumann PA, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS, Nusrat A. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest. 2015 Mar 02; 125(3):1215-27. PMID: 25664854; PMCID: PMC4362251.
  48. Xu X, Ho W, Zhang X, Bertrand N, Farokhzad O. Cancer nanomedicine: from targeted delivery to combination therapy. Trends Mol Med. 2015 Apr; 21(4):223-32. PMID: 25656384; PMCID: PMC4385479.
  49. Maldonado RA, LaMothe RA, Ferrari JD, Zhang AH, Rossi RJ, Kolte PN, Griset AP, O'Neil C, Altreuter DH, Browning E, Johnston L, Farokhzad OC, Langer R, Scott DW, von Andrian UH, Kishimoto TK. Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):E156-65. PMID: 25548186; PMCID: PMC4299193.
  50. Choi WI, Kamaly N, Riol-Blanco L, Lee IH, Wu J, Swami A, Vilos C, Yameen B, Yu M, Shi J, Tabas I, von Andrian UH, Jon S, Farokhzad OC. A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins. Nano Lett. 2014 Nov 12; 14(11):6449-55. PMID: 25333768; PMCID: PMC4245989.
  51. Zhang XQ, Even-Or O, Xu X, van Rosmalen M, Lim L, Gadde S, Farokhzad OC, Fisher EA. Nanoparticles containing a liver X receptor agonist inhibit inflammation and atherosclerosis. Adv Healthc Mater. 2015 Jan 28; 4(2):228-36. PMID: 25156796; PMCID: PMC4527680.
  52. Wu J, Kamaly N, Shi J, Zhao L, Xiao Z, Hollett G, John R, Ray S, Xu X, Zhang X, Kantoff PW, Farokhzad OC. Development of multinuclear polymeric nanoparticles as robust protein nanocarriers. Angew Chem Int Ed Engl. 2014 Aug 18; 53(34):8975-9. PMID: 24990548; PMCID: PMC4143165.
  53. Swami A, Reagan MR, Basto P, Mishima Y, Kamaly N, Glavey S, Zhang S, Moschetta M, Seevaratnam D, Zhang Y, Liu J, Memarzadeh M, Wu J, Manier S, Shi J, Bertrand N, Lu ZN, Nagano K, Baron R, Sacco A, Roccaro AM, Farokhzad OC, Ghobrial IM. Engineered nanomedicine for myeloma and bone microenvironment targeting. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10287-92. PMID: 24982170; PMCID: PMC4104924.
  54. Yameen B, Choi WI, Vilos C, Swami A, Shi J, Farokhzad OC. Insight into nanoparticle cellular uptake and intracellular targeting. J Control Release. 2014 Sep 28; 190:485-99. PMID: 24984011; PMCID: PMC4153400.
  55. Pridgen EM, Alexis F, Farokhzad OC. Polymeric nanoparticle technologies for oral drug delivery. Clin Gastroenterol Hepatol. 2014 Oct; 12(10):1605-10. PMID: 24981782.
    View in: PubMed
  56. Lim JM, Swami A, Gilson LM, Chopra S, Choi S, Wu J, Langer R, Karnik R, Farokhzad OC. Ultra-high throughput synthesis of nanoparticles with homogeneous size distribution using a coaxial turbulent jet mixer. ACS Nano. 2014 Jun 24; 8(6):6056-65. PMID: 24824296; PMCID: PMC4072409.
  57. Gadde S, Even-Or O, Kamaly N, Hasija A, Gagnon PG, Adusumilli KH, Erakovic A, Pal AK, Zhang XQ, Kolishetti N, Shi J, Fisher EA, Farokhzad OC. Development of therapeutic polymeric nanoparticles for the resolution of inflammation. Adv Healthc Mater. 2014 Sep; 3(9):1448-1456. PMID: 24659608; PMCID: PMC4160375.
  58. Shi J, Xu Y, Xu X, Zhu X, Pridgen E, Wu J, Votruba AR, Swami A, Zetter BR, Farokhzad OC. Hybrid lipid-polymer nanoparticles for sustained siRNA delivery and gene silencing. Nanomedicine. 2014 Jul; 10(5):897-900. PMID: 24650883; PMCID: PMC4077924.
  59. Gendelman HE, Balogh LP, Bawa R, Bradbury M, Chang EH, Chiu W, Farokhzad O, Foldvari M, Lanza G, Wang K. The 4th Annual Meeting of the American Society for Nanomedicine. J Neuroimmune Pharmacol. 2014 Mar; 9 Suppl 1:S1-3. PMID: 24550132.
    View in: PubMed
  60. Ilyinskii PO, Roy CJ, O'Neil CP, Browning EA, Pittet LA, Altreuter DH, Alexis F, Tonti E, Shi J, Basto PA, Iannacone M, Radovic-Moreno AF, Langer RS, Farokhzad OC, von Andrian UH, Johnston LP, Kishimoto TK. Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release. Vaccine. 2014 May 19; 32(24):2882-95. PMID: 24593999; PMCID: PMC4059049.
  61. Wang AZ, Farokhzad OC. Current progress of aptamer-based molecular imaging. J Nucl Med. 2014 Mar; 55(3):353-6. PMID: 24525205; PMCID: PMC4110511.
  62. Kim Y, Lobatto ME, Kawahara T, Lee Chung B, Mieszawska AJ, Sanchez-Gaytan BL, Fay F, Senders ML, Calcagno C, Becraft J, Tun Saung M, Gordon RE, Stroes ES, Ma M, Farokhzad OC, Fayad ZA, Mulder WJ, Langer R. Probing nanoparticle translocation across the permeable endothelium in experimental atherosclerosis. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):1078-83. PMID: 24395808; PMCID: PMC3903216.
  63. Pridgen EM, Alexis F, Kuo TT, Levy-Nissenbaum E, Karnik R, Blumberg RS, Langer R, Farokhzad OC. Transepithelial transport of Fc-targeted nanoparticles by the neonatal fc receptor for oral delivery. Sci Transl Med. 2013 Nov 27; 5(213):213ra167. PMID: 24285486; PMCID: PMC4023672.
  64. Bertrand N, Wu J, Xu X, Kamaly N, Farokhzad OC. Cancer nanotechnology: the impact of passive and active targeting in the era of modern cancer biology. Adv Drug Deliv Rev. 2014 Feb; 66:2-25. PMID: 24270007; PMCID: PMC4219254.
  65. Valencia PM, Pridgen EM, Rhee M, Langer R, Farokhzad OC, Karnik R. Microfluidic platform for combinatorial synthesis and optimization of targeted nanoparticles for cancer therapy. ACS Nano. 2013 Dec 23; 7(12):10671-80. PMID: 24215426; PMCID: PMC3963607.
  66. Xu X, Xie K, Zhang XQ, Pridgen EM, Park GY, Cui DS, Shi J, Wu J, Kantoff PW, Lippard SJ, Langer R, Walker GC, Farokhzad OC. Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Proc Natl Acad Sci U S A. 2013 Nov 12; 110(46):18638-43. PMID: 24167294; PMCID: PMC3832000.
  67. Gianella A, Mieszawska AJ, Hoeben FJ, Janssen HM, Jarzyna PA, Cormode DP, Costa KD, Rao S, Farokhzad OC, Langer R, Fayad ZA, Mulder WJ. Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform. Chem Commun (Camb). 2013 Oct 21; 49(82):9392-4. PMID: 23877789; PMCID: PMC3786364.
  68. Kim Y, Fay F, Cormode DP, Sanchez-Gaytan BL, Tang J, Hennessy EJ, Ma M, Moore K, Farokhzad OC, Fisher EA, Mulder WJ, Langer R, Fayad ZA. Single step reconstitution of multifunctional high-density lipoprotein-derived nanomaterials using microfluidics. ACS Nano. 2013 Nov 26; 7(11):9975-83. PMID: 24079940; PMCID: PMC4104519.
  69. Kim Y, Lee Chung B, Ma M, Mulder WJ, Fayad ZA, Farokhzad OC, Langer R. Correction to Mass Production and Size Control of Lipid-Polymer Hybrid Nanoparticles through Controlled Microvortices. Nano Lett. 2013 Oct 9; 13(10):4997. PMID: 24041197.
    View in: PubMed
  70. Mieszawska AJ, Kim Y, Gianella A, van Rooy I, Priem B, Labarre MP, Ozcan C, Cormode DP, Petrov A, Langer R, Farokhzad OC, Fayad ZA, Mulder WJ. Synthesis of polymer-lipid nanoparticles for image-guided delivery of dual modality therapy. Bioconjug Chem. 2013 Sep 18; 24(9):1429-34. PMID: 23957728; PMCID: PMC3810168.
  71. Lim JM, Bertrand N, Valencia PM, Rhee M, Langer R, Jon S, Farokhzad OC, Karnik R. Parallel microfluidic synthesis of size-tunable polymeric nanoparticles using 3D flow focusing towards in vivo study. Nanomedicine. 2014 Feb; 10(2):401-9. PMID: 23969105; PMCID: PMC3951970.
  72. Johnstone TC, Kulak N, Pridgen EM, Farokhzad OC, Langer R, Lippard SJ. Nanoparticle encapsulation of mitaplatin and the effect thereof on in vivo properties. ACS Nano. 2013 Jul 23; 7(7):5675-83. PMID: 23697579; PMCID: PMC3722263.
  73. Kamaly N, Fredman G, Subramanian M, Gadde S, Pesic A, Cheung L, Fayad ZA, Langer R, Tabas I, Farokhzad OC. Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):6506-11. PMID: 23533277; PMCID: PMC3631648.
  74. Prabhakar U, Maeda H, Jain RK, Sevick-Muraca EM, Zamboni W, Farokhzad OC, Barry ST, Gabizon A, Grodzinski P, Blakey DC. Challenges and key considerations of the enhanced permeability and retention effect for nanomedicine drug delivery in oncology. Cancer Res. 2013 Apr 15; 73(8):2412-7. PMID: 23423979; PMCID: PMC3916009.
  75. Zhao W, Cui CH, Bose S, Guo D, Shen C, Wong WP, Halvorsen K, Farokhzad OC, Teo GS, Phillips JA, Dorfman DM, Karnik R, Karp JM. Bioinspired multivalent DNA network for capture and release of cells. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19626-31. PMID: 23150586; PMCID: PMC3511714.
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  77. Xiao Z, Ji C, Shi J, Pridgen EM, Frieder J, Wu J, Farokhzad OC. DNA self-assembly of targeted near-infrared-responsive gold nanoparticles for cancer thermo-chemotherapy. Angew Chem Int Ed Engl. 2012 Nov 19; 51(47):11853-7. PMID: 23081716; PMCID: PMC3532659.
  78. Valencia PM, Pridgen EM, Perea B, Gadde S, Sweeney C, Kantoff PW, Bander NH, Lippard SJ, Langer R, Karnik R, Farokhzad OC. Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles. Nanomedicine (Lond). 2013 May; 8(5):687-98. PMID: 23075285.
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  80. Zhang XQ, Xu X, Bertrand N, Pridgen E, Swami A, Farokhzad OC. Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine. Adv Drug Deliv Rev. 2012 Oct; 64(13):1363-84. PMID: 22917779; PMCID: PMC3517211.
  81. Farokhzad OC. Using ligands to target cancer cells. Clin Adv Hematol Oncol. 2012 Aug; 10(8):543-4. PMID: 23073055.
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  83. Graf N, Bielenberg DR, Kolishetti N, Muus C, Banyard J, Farokhzad OC, Lippard SJ. a(V)ß(3) integrin-targeted PLGA-PEG nanoparticles for enhanced anti-tumor efficacy of a Pt(IV) prodrug. ACS Nano. 2012 May 22; 6(5):4530-9. PMID: 22584163; PMCID: PMC3358506.
  84. Xiao Z, Farokhzad OC. Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities. ACS Nano. 2012 May 22; 6(5):3670-6. PMID: 22574989; PMCID: PMC3420009.
  85. Mieszawska AJ, Gianella A, Cormode DP, Zhao Y, Meijerink A, Langer R, Farokhzad OC, Fayad ZA, Mulder WJ. Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging. Chem Commun (Camb). 2012 Jun 14; 48(47):5835-7. PMID: 22555311; PMCID: PMC3593599.
  86. Radovic-Moreno AF, Lu TK, Puscasu VA, Yoon CJ, Langer R, Farokhzad OC. Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics. ACS Nano. 2012 May 22; 6(5):4279-87. PMID: 22471841; PMCID: PMC3779925.
  87. Hrkach J, Von Hoff D, Mukkaram Ali M, Andrianova E, Auer J, Campbell T, De Witt D, Figa M, Figueiredo M, Horhota A, Low S, McDonnell K, Peeke E, Retnarajan B, Sabnis A, Schnipper E, Song JJ, Song YH, Summa J, Tompsett D, Troiano G, Van Geen Hoven T, Wright J, LoRusso P, Kantoff PW, Bander NH, Sweeney C, Farokhzad OC, Langer R, Zale S. Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Sci Transl Med. 2012 Apr 04; 4(128):128ra39. PMID: 22491949.
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  88. Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF, Farokhzad OC. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chem Soc Rev. 2012 Apr 07; 41(7):2971-3010. PMID: 22388185; PMCID: PMC3684255.
  89. Xiao Z, Levy-Nissenbaum E, Alexis F, Lupták A, Teply BA, Chan JM, Shi J, Digga E, Cheng J, Langer R, Farokhzad OC. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano. 2012 Jan 24; 6(1):696-704. PMID: 22214176; PMCID: PMC3515647.
  90. Chan JM, Rhee JW, Drum CL, Bronson RT, Golomb G, Langer R, Farokhzad OC. In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19347-52. PMID: 22087004; PMCID: PMC3228458.
  91. Wang AZ, Langer R, Farokhzad OC. Nanoparticle delivery of cancer drugs. Annu Rev Med. 2012; 63:185-98. PMID: 21888516.
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  92. Gao W, Farokhzad OC. Self-propelled microrockets to capture and isolate circulating tumor cells. Angew Chem Int Ed Engl. 2011 Aug 01; 50(32):7220-1. PMID: 21728224.
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  93. Shi J, Xiao Z, Votruba AR, Vilos C, Farokhzad OC. Differentially charged hollow core/shell lipid-polymer-lipid hybrid nanoparticles for small interfering RNA delivery. Angew Chem Int Ed Engl. 2011 Jul 25; 50(31):7027-31. PMID: 21698724; PMCID: PMC3515655.
  94. Shi J, Xiao Z, Kamaly N, Farokhzad OC. Self-assembled targeted nanoparticles: evolution of technologies and bench to bedside translation. Acc Chem Res. 2011 Oct 18; 44(10):1123-34. PMID: 21692448.
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  96. Rhee M, Valencia PM, Rodriguez MI, Langer R, Farokhzad OC, Karnik R. Synthesis of size-tunable polymeric nanoparticles enabled by 3D hydrodynamic flow focusing in single-layer microchannels. Adv Mater. 2011 Mar 25; 23(12):H79-83. PMID: 21433105; PMCID: PMC3123733.
  97. Dhar S, Kolishetti N, Lippard SJ, Farokhzad OC. Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1850-5. PMID: 21233423; PMCID: PMC3033286.
  98. Burgess P, Hutt PB, Farokhzad OC, Langer R, Minick S, Zale S. On firm ground: IP protection of therapeutic nanoparticles. Nat Biotechnol. 2010 Dec; 28(12):1267-70. PMID: 21139609.
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  99. Gao W, Chan JM, Farokhzad OC. pH-Responsive nanoparticles for drug delivery. Mol Pharm. 2010 Dec 06; 7(6):1913-20. PMID: 20836539; PMCID: PMC3379544.
  100. Kolishetti N, Dhar S, Valencia PM, Lin LQ, Karnik R, Lippard SJ, Langer R, Farokhzad OC. Engineering of self-assembled nanoparticle platform for precisely controlled combination drug therapy. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):17939-44. PMID: 20921363; PMCID: PMC2964221.
  101. Shi J, Votruba AR, Farokhzad OC, Langer R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett. 2010 Sep 08; 10(9):3223-30. PMID: 20726522; PMCID: PMC2935937.
  102. Gao W, Langer R, Farokhzad OC. Poly(ethylene glycol) with observable shedding. Angew Chem Int Ed Engl. 2010 Sep 03; 49(37):6567-71. PMID: 20677297; PMCID: PMC3131112.
  103. Shi J, Votruba AR, Farokhzad OC, Langer R. Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications. Nano Letters. 2010; Epub ahead of print.
  104. Gao W, Langer R, Farokhzad OC. Poly(ethylene glycol) with Observable Shedding. Angew Chem Int Ed Engl. 2010; Epub ahead of print.
  105. Ludwig FN, Hossainy SF, Svensson B, Sharkawy A, Cima M, Farokhzad OC, Magana J, Von Oepen R, Chow M, Webler WE, Yribarren TR, Ehrenreich KJ. Magnetically sensitive drug carriers and delivery devices. 2010.
  106. Farokhzad OC, Levy-Nissenbaum E, Langer RS, Alexis F. Oligonucleotide systems for targeted intracellular delivery. 2010.
  107. Farokhzad OC, Jon SY, Langer RS. Controlled release nanoparticle having bound oligonucleotide for targeted delivery. 2010.
  108. Shi J, Alexis F, Iannacone M, Moseman A, Basto P, Langer R, Farokhzad OC, von Andrian U. Targeting of antigen presenting cells with immunonanotherapeutics. 2010.
  109. Alexis F, Shi J, Iannacone M, Moseman A, Basto P, Langer R, Farokhzad OC, von Andrian U. Adjuvant incorporation in immunonanotherapeutics. 2010.
  110. Lippard SJ, Dhar S, Farokhzad OC, Kolishetti N, Gu FX. Nanostructures for drug delivery. 2010.
  111. Shi J, Alexis F, Iannacone M, Moseman A, Basto P, Langer R, Farokhzad OC, von Andrian U, Tonti E. Targeting of antigen presenting cells with immunonanotherapeutics. 2010.
  112. Iannacone M, von Andrian U, Farokhzad OC, Alexis F, Basto P, Shi J, Moseman A, Langer R, Tonti E. Nicotine immunonanotherapeutics. 2010.
  113. Farokhzad OC, Salvador-Morales C, Gao W, Zhang L, Chen JM, Langer RS. Particles with multiple functionalized surface domains. 2010.
  114. Iannacone M, Alexis F, Basto P, Moseman A, Shi J, Langer R, Farokhzad OC, von Andrian U, Tonti E. Immunonanotherapeutics that provide IgG humoral response without T-cell antigen. 2010.
  115. Alexis F, Iannacone M, Shi J, Basto P, Moseman A, von Andrian U, Langer R, Farokhzad OC, Tonti E. Adjuvant incorporation in immunonanotherapeutics. 2010.
  116. von Andrian U, Farokhzad OC, Alexis F, Iannacone M, Basto P, Shi J, Moseman A, Langer R. Nicotine immunonanotherapeutics. 2010.
  117. Von Andrian UH, Farokhzad OC, Langer RS, Junt T, Moseman A, Zhang L, Basto P, Iannacone M, Alexis F. Vaccine nanotechnology. 2010.
  118. Wang AZ, Yuet K, Zhang L, Gu FX, Huynh-Le M, Radovic-Moreno AF, Kantoff PW, Bander NH, Langer R, Farokhzad OC. ChemoRad nanoparticles: a novel multifunctional nanoparticle platform for targeted delivery of concurrent chemoradiation. Nanomedicine (Lond). 2010 Apr; 5(3):361-8. PMID: 20394530; PMCID: PMC2901911.
  119. Valencia PM, Basto PA, Zhang L, Rhee M, Langer R, Farokhzad OC, Karnik R. Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing. ACS Nano. 2010 Mar 23; 4(3):1671-9. PMID: 20166699; PMCID: PMC2923464.
  120. Mamo T, Moseman EA, Kolishetti N, Salvador-Morales C, Shi J, Kuritzkes DR, Langer R, von Andrian U, Farokhzad OC. Emerging nanotechnology approaches for HIV/AIDS treatment and prevention. Nanomed. 2010; 5(2):269-85.
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  122. Karnik R, Gu FX, Basto P, Cannizzaro C, Khademhosseini A, Langer RS, Farokhzad OC. Microfluidic synthesis of organic nanoparticles. 2010.
  123. Alexis F, Zhang L, Radovic-Moreno AF, Gu FX, Basto P, Levy-Nissenbaum E, Chan J, Langer RS, Farokhzad OC. Poly (amino acid) targeting moieties. 2010.
  124. Chan JM, Zhang L, Tong R, Ghosh D, Gao W, Liao G, Yuet KP, Gray D, Rhee JW, Cheng J, Golomb G, Libby P, Langer R, Farokhzad OC. Spatiotemporal controlled delivery of nanoparticles to injured vasculature. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):2213-8. PMID: 20133865; PMCID: PMC2836709.
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  128. Langer RS, Farokhzad OC, Chan JM. Endothelial basement membrane targeting peptide ligands. 2009.
  129. Radovic-Moreno AF, Zhang L, Langer RS, Farokhzad OC. Polymer-encapsulated reverse micelles. 2009.
  130. Zhang L, Radovic-Moreno AF, Gu FX, Alexis F, Langer RS, Farokhzad OC. Amphiphilic compound assisted nanoparticles for targeted delivery. 2009.
  131. Wang AZ, Farokhzad OC, Zhang L, Radovic-Moreno A, Gu FX, Langer RS. Drug delivery system for pharmaceuticals and radiation. 2009.
  132. Farokhzad OC, Jon S, Langer RS. Controlled release polymer nanoparticles containing bound nucleic acid ligand for targeting. 2009.
  133. Farokhzad OC, Alexis F, Kuo T, Pridgen E, Radovic-Moreno AF, Langer RS. Drug delivery system using FC fragments. 2009.
  134. von Andrian UH, Farokhzad OC, Langer RS, Junt T, Moseman A, Zhang L, Basto P, Iannacone M, Alexis F. Vaccine nanotechnology. 2009.
  135. Radovic-Moreno AF, Langer RS, Golomb G, Gao W, Farokhzad OC. PH sensitive biodegradable polymeric particles for drug delivery. 2009.
  136. Bassett EK, Slocum AH, Masiakos PT, Pryor HI, Farokhzad OC, Karp JM. Design of a mechanical clutch-based needle-insertion device. Proc Natl Acad Sci U S A. 2009 Apr 07; 106(14):5540-5. PMID: 19307560; PMCID: PMC2667015.
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  138. Salvador-Morales C, Gao W, Ghatalia P, Murshed F, Aizu W, Langer R, Farokhzad OC. Multifunctional nanoparticles for prostate cancer therapy. Expert Rev Anticancer Ther. 2009 Feb; 9(2):211-21. PMID: 19192959.
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  144. Alexis F, Basto P, Levy-Nissenbaum E, Radovic-Moreno AF, Zhang L, Pridgen E, Wang AZ, Marein SL, Westerhof K, Molnar LK, Farokhzad OC. HER-2-targeted nanoparticle-affibody bioconjugates for cancer therapy. ChemMedChem. 2008 Dec; 3(12):1839-43. PMID: 19012296; PMCID: PMC3515656.
  145. Gu FX, Teply BA, Langer RS, Farokhzad OC. Polymers for functional particles. 2008.
  146. Dhar S, Gu FX, Langer R, Farokhzad OC, Lippard SJ. Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA-PEG nanoparticles. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17356-61. PMID: 18978032; PMCID: PMC2582270.
  147. Radovic-Moreno AF, Zhang L, Langer RS, Farokhzad OC. Polymer-encapsulated reverse micelles. 2008.
  148. Zhang L, Radovic-Moreno AF, Gu FX, Alexis F, Langer RS, Farokhzad OC. Amphiphilic compound assisted nanoparticles for targeted delivery. 2008.
  149. Alexis F, Zhang L, Radovic-Moreno AF, Gu FX, Basto P, Levy-Nissenbaum E, Chan J, Langer RS, Farokhzad OC. Poly(amino acid) targeting moieties. 2008.
  150. Farokhzad OC, Cheng J, Tepley BA, Langer RS, Zale SE. System for targeted delivery of therapeutic agents. 2008.
  151. Farokhzad OC, Cheng J, Teply BA, Langer RS, Zale SE. System for targeted delivery of therapeutic agents. 2008.
  152. Wang AZ, Bagalkot V, Vasilliou CC, Gu F, Alexis F, Zhang L, Shaikh M, Yuet K, Cima MJ, Langer R, Kantoff PW, Bander NH, Jon S, Farokhzad OC. Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem. 2008 Sep; 3(9):1311-5. PMID: 18613203; PMCID: PMC3131111.
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  155. Slocum A, Bassett E, Karp JM, Langer R, Farokhzad OC. Methods and devices for sensing tissues and tissue compartments. 2008.
  156. Alexis F, Pridgen E, Molnar LK, Farokhzad OC. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol Pharm. 2008 Jul-Aug; 5(4):505-15. PMID: 18672949; PMCID: PMC2663893.
  157. Wang AZ, Gu F, Zhang L, Chan JM, Radovic-Moreno A, Shaikh MR, Farokhzad OC. Biofunctionalized targeted nanoparticles for therapeutic applications. Expert Opin Biol Ther. 2008 Aug; 8(8):1063-70. PMID: 18613759; PMCID: PMC3515649.
  158. Zhang L, Chan JM, Gu FX, Rhee JW, Wang AZ, Radovic-Moreno AF, Alexis F, Langer R, Farokhzad OC. Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform. ACS Nano. 2008 Aug; 2(8):1696-702. PMID: 19206374; PMCID: PMC4477795.
  159. Karnik R, Gu F, Basto P, Cannizzaro C, Dean L, Kyei-Manu W, Langer R, Farokhzad OC. Microfluidic platform for controlled synthesis of polymeric nanoparticles. Nano Lett. 2008 Sep; 8(9):2906-12. PMID: 18656990.
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  162. Farokhzad OC, Levy-Nissenbaum E, Langer R, Alexis F. Oligonucleotide systems for targeted intracellular delivery. 2008.
  163. Gu F, Zhang L, Teply BA, Mann N, Wang A, Radovic-Moreno AF, Langer R, Farokhzad OC. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block copolymers. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2586-91. PMID: 18272481; PMCID: PMC2268180.
  164. Wang AZ, Guimaraes A, Zhang L, Gu F, Langer R, Weissleder R, Farokhzad OC. Development of novel multifunctional nanoparticles for combined imaging and targeted delivery of chemoradiotherapy. International Journal of Radiation Oncology*Biology*Physics. 2008; 72(1):S707.
  165. Alexis F, Rhee JW, Richie JP, Radovic-Moreno AF, Langer R, Farokhzad OC. New frontiers in nanotechnology for cancer treatment. Urol Oncol. 2008 Jan-Feb; 26(1):74-85. PMID: 18190835.
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  167. Teply BA, Tong R, Jeong SY, Luther G, Sherifi I, Yim CH, Khademhosseini A, Farokhzad OC, Langer RS, Cheng J. The use of charge-coupled polymeric microparticles and micromagnets for modulating the bioavailability of orally delivered macromolecules. Biomaterials. 2008 Mar; 29(9):1216-23. PMID: 18082254; PMCID: PMC2268909.
  168. Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol. 2007 Dec; 2(12):751-60. PMID: 18654426.
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  171. Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC. Nanoparticles in medicine: therapeutic applications and developments. Clin Pharmacol Ther. 2008 May; 83(5):761-9. PMID: 17957183.
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  175. Basto P, Farokhzad OC, Junt T, Langer RS, Moseman A, Von Andrian UH, Zhang L. Vaccine Nanotechnology and Uses Thereof. 2007.
  176. Zhang L, Radovic-Moreno AF, Alexis F, Gu FX, Basto PA, Bagalkot V, Jon S, Langer RS, Farokhzad OC. Co-delivery of hydrophobic and hydrophilic drugs from nanoparticle-aptamer bioconjugates. ChemMedChem. 2007 Sep; 2(9):1268-71. PMID: 17600796.
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  177. Park H, Cannizzaro C, Vunjak-Novakovic G, Langer R, Vacanti CA, Farokhzad OC. Nanofabrication and microfabrication of functional materials for tissue engineering. Tissue Eng. 2007 Aug; 13(8):1867-77. PMID: 17518744.
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  180. Farokhzad OC, Jon S, Langer R. Aptamers and Cancer Nanotechnology. In: Nanotechnology for Cancer Therapy; Editor: Amiji M. 2007; 289-313.
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  182. Farokhzad OC, Alexis F, Levy-Nissenbaum E, Zhang L, Langer R. Polyamino acid-targeted drug delivery. 2007.
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  184. Radovic-Moreno AF, Fuller J, Nguyen DN, Langer R, Farokhzad OC. Nanotechnology: Delivering on the Promise of Nucleic Acid Therapeutics. Oligonucleotide. 2007; Invited Review (submitted).
  185. Jon SY, Farokhzad OC, Langer RS. Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals. 2007.
  186. Wang AZ, Bagalkot V, Gu F, Alexis F, Vasilliou C, Cima M, Jon S, Farokhzad OC. Novel targeted aptamer-superparamagnetic iron oxide nanoparticles bioconjugates for combined prostate cancer imaging and therapy. International Journal of Radiation Oncology*Biology*Physics. 2007; 69(3):S110-1.
  187. Gu FX, Karnik R, Wang AZ, Alexis F, Levy-Nissenbaum E, Hong S, Langer RS, Farokhzad OC. Targeted nanoparticles for cancer therapy. Nano Today. 2007; 2(3):14-21.
  188. Bagalvot V, Farokhzad OC, Langer R, Sangyong J. Aptamer-dox conjugates as novel platform for targeted drug delivery and imaging. Nanomedicine: Nanotechnology, Biology, and Medicine. 2007; 3(4):352.
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  190. Bagalkot V, Farokhzad OC, Langer R, Jon S. An aptamer-doxorubicin physical conjugate as a novel targeted drug-delivery platform. Angew Chem Int Ed Engl. 2006 Dec 11; 45(48):8149-52. PMID: 17099918.
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  192. Farokhzad OC, Karp J, Slocum A, Langer R. A device for sensing tissues and tissue compartments. 2006.
  193. Farokhzad OC, Alexis F, Kuo T, Langer R. Receptor Triggered Controlled Drug Delivery Systems to Cross Endothelial and/or Epithelial Cell Layers and their Method of Preparation. 2006.
  194. Farokhzad OC, Langer R. Nanomedicine: developing smarter therapeutic and diagnostic modalities. Adv Drug Deliv Rev. 2006 Dec 01; 58(14):1456-9. PMID: 17070960.
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  195. Cheng J, Teply BA, Sherifi I, Sung J, Luther G, Gu FX, Levy-Nissenbaum E, Radovic-Moreno AF, Langer R, Farokhzad OC. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials. 2007 Feb; 28(5):869-76. PMID: 17055572; PMCID: PMC2925222.
  196. Cheng J, Farokhzad OC, Teply B and Langer RS. Magnetically-labeled microparticles for oral drug delivery. 2006.
  197. Farokhzad OC, Alexis F, Gu F, Radovic-Moreno A, Langer R. Affibodies as a Targeting Ligand in Controlled Drug Delivery Systems. 2006.
  198. Shelley CS and Farokhzad OC. Methods for Diagnosing and Treating Tumors and Suppressing CD Promoters. 2006.
  199. Teply BA, Rocha FG, Levy-Nissenbaum E, Langer R, Farokhzad OC. Nanoparticle-aptamer bioconjugates for targeted antineoplastic drug delivery. Am J Drug Del. 2006; 4(3):123-30.
  200. Farokhzad OC, Dimitrakov JD, Karp JM, Khademhosseini A, Freeman MR, Langer R. Drug delivery systems in urology--getting "smarter". Urology. 2006 Sep; 68(3):463-9. PMID: 17010721; PMCID: PMC1618825.
  201. Farokhzad OC, Karp JM, Langer R. Nanoparticle-aptamer bioconjugates for cancer targeting. Expert Opin Drug Deliv. 2006 May; 3(3):311-24. PMID: 16640493.
    View in: PubMed
  202. Farokhzad OC, Cheng J, Teply BA, Sherifi I, Jon S, Kantoff PW, Richie JP, Langer R. Targeted nanoparticle-aptamer bioconjugates for cancer chemotherapy in vivo. Proc Natl Acad Sci U S A. 2006 Apr 18; 103(16):6315-20. PMID: 16606824; PMCID: PMC1458875.
  203. Farokhzad OC, Khademhosseini A, Langer R. High throughput synthesis of functionalized materials. 2006.
  204. Farokhzad OC, Langer R. Method of identifying particles that target certain cells, tissues or organs. 2006.
  205. Cheng J, Teply BA, Jeong SY, Yim CH, Ho D, Sherifi I, Jon S, Farokhzad OC, Khademhosseini A, Langer RS. Magnetically responsive polymeric microparticles for oral delivery of protein drugs. Pharm Res. 2006 Mar; 23(3):557-64. PMID: 16388405.
    View in: PubMed
  206. Farokhzad OC, Cheng J, Teply B, Khademhosseini A, Jon S, Levy-Nissenbaum E, Langer R. Cancer nanotechnology: drug encapsulated nanoparticle-aptamer bioconjugates for targeted delivery to prostate cancer cells. Federation of European Cancer Societies. 2005.
  207. Fukuda J, Khademhosseini A, Yeh J, Eng G, Cheng J, Farokhzad OC, Langer R. Micropatterned cell co-cultures using layer-by-layer deposition of extracellular matrix components. Biomaterials. 2006 Mar; 27(8):1479-86. PMID: 16242769.
    View in: PubMed
  208. Khademhosseini A, Yeh J, Eng G, Karp J, Kaji H, Borenstein J, Farokhzad OC, Langer R. Cell docking inside microwells within reversibly sealed microfluidic channels for fabricating multiphenotype cell arrays. Lab Chip. 2005 Dec; 5(12):1380-6. PMID: 16286969.
    View in: PubMed
  209. Farokhzad OC, Khademhosseini A, Jon S, Hermmann A, Cheng J, Chin C, Kiselyuk A, Teply B, Eng G, Langer R. Microfluidic system for studying the interaction of nanoparticles and microparticles with cells. Anal Chem. 2005 Sep 01; 77(17):5453-9. PMID: 16131052.
    View in: PubMed
  210. Farokhzad OC, Jon SY and Langer RS. Targeted delivery of controlled release polymer systems. 2005.
  211. Cheng J, Farokhzad OC, Teply B and Langer RS. Magnetically-labeled microparticles for oral drug delivery. 2005.
  212. Farokhzad OC, Jon SY and Langer RS. Targeted delivery of controlled release polymer systems. 2005.
  213. Cheng J, Teply BA, Sherifi I, Khademhosseini A, Langer R, Farokhzad OC. PLGA nanoparticle-aptamer bioconjugate as drug delivery vehicles for targeted prostate cancer therapy. Third International Nanomedicine and Drug Delivery Symposium, Baltimore, MD. 2005.
  214. Farokhzad OC, Jon SY and Langer RS. Targeted delivery of controlled release polymer systems. 2004.
  215. Jon SY, Farokhzad OC and Langer RS. Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals. 2004.
  216. Farokhzad OC, Jon S, Khademhosseini A, Tran TN, Lavan DA, Langer R. Nanoparticle-aptamer bioconjugates: a new approach for targeting prostate cancer cells. Cancer Res. 2004 Nov 01; 64(21):7668-72. PMID: 15520166.
    View in: PubMed
  217. Shelley CS and Farokhzad OC. Method of treating tumors and suppressing CD promoters. 2004.
  218. Farokhzad OC, Jon SY and Langer RS. Targeted delivery of controlled release polymer systems. 2003.
  219. Nicolaou F, Teodoridis JM, Park H, Georgakis A, Farokhzad OC, Böttinger EP, Da Silva N, Rousselot P, Chomienne C, Ferenczi K, Arnaout MA, Shelley CS. CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD. Blood. 2003 May 15; 101(10):4033-41. PMID: 12576324.
    View in: PubMed
  220. Shelley CS, Teodoridis JM, Park H, Farokhzad OC, Böttinger EP, Arnaout MA. During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter. J Immunol. 2002 Apr 15; 168(8):3887-93. PMID: 11937543.
    View in: PubMed
  221. Song JC, Hanson CM, Tsai V, Farokhzad OC, Lotz M, Matthews JB. Regulation of epithelial transport and barrier function by distinct protein kinase C isoforms. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C649-61. PMID: 11443064.
    View in: PubMed
  222. Farokhzad OC, Teodoridis JM, Park H, Arnaout MA, Shelley CS. CD43 gene expression is mediated by a nuclear factor which binds pyrimidine-rich single-stranded DNA. Nucleic Acids Res. 2000 Jun 01; 28(11):2256-67. PMID: 10871347; PMCID: PMC102628.
  223. Kyei-Aboagye K, Kasznica J, Pomeroy O, Farokhzad OC, and Noel J. . Double uterus with unilateral cervical dysgenesis and ipsilateral renal agenesis. Journal of Pelvic Surgery. 2000; 6:98-101.
  224. Farokhzad OC, Sagar GD, Mun EC, Sicklick JK, Lotz M, Smith JA, Song JC, O'Brien TC, Sharma CP, Kinane TB, Hodin RA, Matthews JB. Protein kinase C activation downregulates the expression and function of the basolateral Na+/K+/2Cl(-) cotransporter. J Cell Physiol. 1999 Dec; 181(3):489-98. PMID: 10528235.
    View in: PubMed
  225. Song JC, Hrnjez BJ, Farokhzad OC, Matthews JB. PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS. Am J Physiol. 1999 12; 277(6):C1239-49. PMID: 10600776.
    View in: PubMed
  226. Sagar V. Song JC, Farokhzad OC, and Matthews JB. Regulation of NICC1 surface expression by Protein Kinase C. Gastroenterology. 1999; 116:G4021.
  227. Farokhzad OC, Mun EC, Sicklick JK, Smith JA, Matthews JB. Effects of bryostatin 1, a novel anticancer agent, on intestinal transport and barrier function: role of protein kinase C. Surgery. 1998 Aug; 124(2):380-6; discussion 386-7. PMID: 9706162.
    View in: PubMed
  228. Mun EC, Mayol JM, Riegler M, O'Brien TC, Farokhzad OC, Song JC, Pothoulakis C, Hrnjez BJ, Matthews JB. Levamisole inhibits intestinal Cl- secretion via basolateral K+ channel blockade. Gastroenterology. 1998 Jun; 114(6):1257-67. PMID: 9609763.
    View in: PubMed
  229. Farokhzad OC, Shelley CS, Arnaout MA. Induction of the CD11b gene during activation of the monocytic cell line U937 requires a novel nuclear factor MS-2. J Immunol. 1996 Dec 15; 157(12):5597-605. PMID: 8955212.
    View in: PubMed
  230. Böttinger EP, Shelley CS, Farokhzad OC, Arnaout MA. The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements. Mol Cell Biol. 1994 Apr; 14(4):2604-15. PMID: 7511209; PMCID: PMC358628.
  231. Bottinger EP, Factor V, Tsang ML-S, Weatherbee JA, Qian S, Farokhzad OC, Wakefield LM, Thorgeirsson SS, Kopp JB, Roberts AB, and Sporn MB. The recombinant proregion of transforming growth factor beta1 modulates its activity in-vitro and in-vivo. Journal of the American Society of Nephrology. 1994; 5:689.
  232. Shelley CS, Farokhzad OC, Arnaout MA. Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5364-8. PMID: 8099450; PMCID: PMC46717.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.