Harvard Catalyst Profiles

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Sudha Biddinger, M.D.,Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R56DK128356 (BIDDINGER, SUDHA B) Sep 16, 2021 - Aug 31, 2022
    NIH
    Dissecting the Role of Trimethylamine N-oxide in Chronic Kidney Disease Development
    Role: Principal Investigator
  2. R01DK125898 (BIDDINGER, SUDHA B) May 1, 2021 - Apr 30, 2026
    NIH
    Insulin Regulation of Hepatic Function via Zone-Specific Transcriptional Programs
    Role: Principal Investigator
  3. T32DK128781 (LEE, CHIH-HAO) May 1, 2021 - Apr 30, 2026
    NIH
    Training Program in Molecular Metabolism
    Role: Co-Principal Investigator
  4. R01DK094162 (BIDDINGER, SUDHA B) May 19, 2012 - Apr 30, 2017
    NIH
    Control of lipid metabolism in insulin resistant states
    Role: Principal Investigator
  5. R01HL109650 (BIDDINGER, SUDHA B) Sep 1, 2011 - Jun 30, 2025
    NIH
    Pathogenesis of Dyslipidemia and Atherosclerosis in the Diabetic State
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gosis BS, Wada S, Thorsheim C, Li K, Jung S, Rhoades JH, Yang Y, Brandimarto J, Li L, Uehara K, Jang C, Lanza M, Sanford NB, Bornstein MR, Jeong S, Titchenell PM, Biddinger SB, Arany Z. Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1. Science. 2022 04 15; 376(6590):eabf8271. PMID: 35420934; PMCID: PMC9811404.
    Citations: 15     Fields:    Translation:Animals
  2. Dornbos P, Singh P, Jang DK, Mahajan A, Biddinger SB, Rotter JI, McCarthy MI, Flannick J. Evaluating human genetic support for hypothesized metabolic disease genes. Cell Metab. 2022 05 03; 34(5):661-666. PMID: 35421386; PMCID: PMC9166611.
    Citations: 2     Fields:    Translation:Humans
  3. Semova I, Levenson AE, Krawczyk J, Bullock K, Gearing ME, Ling AV, Williams KA, Miao J, Adamson SS, Shin DJ, Chahar S, Graham MJ, Crooke RM, Hagey LR, Vicent D, de Ferranti SD, Kidambi S, Clish CB, Biddinger SB. Insulin Prevents Hypercholesterolemia by Suppressing 12a-Hydroxylated Bile Acids. Circulation. 2022 03 29; 145(13):969-982. PMID: 35193378; PMCID: PMC9365453.
    Citations: 5     Fields:    Translation:HumansAnimals
  4. Semova I, Biddinger SB. Triglycerides in Nonalcoholic Fatty Liver Disease: Guilty Until Proven Innocent. Trends Pharmacol Sci. 2021 03; 42(3):183-190. PMID: 33468321.
    Citations: 7     Fields:    Translation:HumansCells
  5. Semova I, Levenson AE, Krawczyk J, Bullock K, Williams KA, Wadwa RP, Khoury PR, Kimball TR, Urbina EM, de Ferranti SD, Maahs DM, Dolan LM, Shah AS, Clish CB, Biddinger SB. Markers of cholesterol synthesis are elevated in adolescents and young adults with type 2 diabetes. Pediatr Diabetes. 2020 11; 21(7):1126-1131. PMID: 32738021.
    Citations: 2     Fields:    Translation:Humans
  6. Semova I, Levenson AE, Krawczyk J, Bullock K, Williams KA, Wadwa RP, Shah AS, Khoury PR, Kimball TR, Urbina EM, de Ferranti SD, Bishop FK, Maahs DM, Dolan LM, Clish CB, Biddinger SB. Type 1 diabetes is associated with an increase in cholesterol absorption markers but a decrease in cholesterol synthesis markers in a young adult population. J Clin Lipidol. 2019 Nov - Dec; 13(6):940-946. PMID: 31706902.
    Citations: 8     Fields:    Translation:Humans
  7. Chen S, Henderson A, Petriello MC, Romano KA, Gearing M, Miao J, Schell M, Sandoval-Espinola WJ, Tao J, Sha B, Graham M, Crooke R, Kleinridders A, Balskus EP, Rey FE, Morris AJ, Biddinger SB. Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction. Cell Metab. 2019 12 03; 30(6):1141-1151.e5. PMID: 31543404.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  8. Hung YH, Kanke M, Kurtz CL, Cubitt R, Bunaciu RP, Miao J, Zhou L, Graham JL, Hussain MM, Havel P, Biddinger S, White PJ, Sethupathy P. Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice. Physiol Genomics. 2019 08 01; 51(8):379-389. PMID: 31251698; PMCID: PMC6732414.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  9. Coffey AR, Kanke M, Smallwood TL, Albright J, Pitman W, Gharaibeh RZ, Hua K, Gertz E, Biddinger SB, Temel RE, Pomp D, Sethupathy P, Bennett BJ. microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO. Physiol Genomics. 2019 02 01; 51(2):59-71. PMID: 30633643.
    Citations: 18     Fields:    Translation:Animals
  10. Meakin PJ, Mezzapesa A, Benabou E, Haas ME, Bonardo B, Grino M, Brunel JM, Desbois-Mouthon C, Biddinger SB, Govers R, Ashford MLJ, Peiretti F. The beta secretase BACE1 regulates the expression of insulin receptor in the liver. Nat Commun. 2018 04 03; 9(1):1306. PMID: 29610518; PMCID: PMC5880807.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  11. Ling AV, Gearing ME, Semova I, Shin DJ, Clements R, Lai ZW, Biddinger SB. FoxO1 Is Required for Most of the Metabolic and Hormonal Perturbations Produced by Hepatic Insulin Receptor Deletion in Male Mice. Endocrinology. 2018 03 01; 159(3):1253-1263. PMID: 29300910; PMCID: PMC5802805.
    Citations: 13     Fields:    Translation:AnimalsCells
  12. Meoli L, Gupta NK, Saeidi N, Panciotti CA, Biddinger SB, Corey KE, Stylopoulos N. Nonalcoholic fatty liver disease and gastric bypass surgery regulate serum and hepatic levels of pyruvate kinase isoenzyme M2. Am J Physiol Endocrinol Metab. 2018 10 01; 315(4):E613-E621. PMID: 29462566; PMCID: PMC6230703.
    Citations: 5     Fields:    Translation:HumansAnimals
  13. Hu Y, Semova I, Sun X, Kang H, Chahar S, Hollenberg AN, Masson D, Hirschey MD, Miao J, Biddinger SB. Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways. J Biol Chem. 2018 02 09; 293(6):2006-2014. PMID: 29222328.
    Citations: 8     Fields:    Translation:AnimalsCells
  14. Hu Y, Shin DJ, Pan H, Lin Z, Dreyfuss JM, Camargo FD, Miao J, Biddinger SB. YAP suppresses gluconeogenic gene expression through PGC1a. Hepatology. 2017 12; 66(6):2029-2041. PMID: 28714135; PMCID: PMC6082140.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  15. Levenson AE, Wadwa RP, Shah AS, Khoury PR, Kimball TR, Urbina EM, de Ferranti SD, Bishop FK, Maahs DM, Dolan LM, Biddinger SB. PCSK9 Is Increased in Youth With Type 1 Diabetes. Diabetes Care. 2017 07; 40(7):e85-e87. PMID: 28588146.
    Citations: 6     Fields:    
  16. Key CC, Liu M, Kurtz CL, Chung S, Boudyguina E, Dinh TA, Bashore A, Phelan PE, Freedman BI, Osborne TF, Zhu X, Ma L, Sethupathy P, Biddinger SB, Parks JS. Hepatocyte ABCA1 Deletion Impairs Liver Insulin Signaling and Lipogenesis. Cell Rep. 2017 06 06; 19(10):2116-2129. PMID: 28591582.
    Citations: 16     Fields:    Translation:AnimalsCells
  17. Levenson AE, Shah AS, Khoury PR, Kimball TR, Urbina EM, de Ferranti SD, Maahs DM, Dolan LM, Wadwa RP, Biddinger SB. Obesity and type 2 diabetes are associated with elevated PCSK9 levels in young women. Pediatr Diabetes. 2017 Dec; 18(8):755-760. PMID: 28093849.
    Citations: 18     Fields:    Translation:Humans
  18. Levenson AE, Milliren CE, Biddinger SB, Ebbeling CB, Feldman HA, Ludwig DS, de Ferranti SD. Calorically restricted diets decrease PCSK9 in overweight adolescents. Nutr Metab Cardiovasc Dis. 2017 Apr; 27(4):342-349. PMID: 28228332.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  19. Haas ME, Levenson AE, Sun X, Liao WH, Rutkowski JM, de Ferranti SD, Schumacher VA, Scherer PE, Salant DJ, Biddinger SB. The Role of Proprotein Convertase Subtilisin/Kexin Type 9 in Nephrotic Syndrome-Associated Hypercholesterolemia. Circulation. 2016 Jul 05; 134(1):61-72. PMID: 27358438; PMCID: PMC5345853.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  20. Kassai A, Muniyappa R, Levenson AE, Walter MF, Abel BS, Ring M, Taylor SI, Biddinger SB, Skarulis MC, Gorden P, Brown RJ. Effect of Leptin Administration on Circulating Apolipoprotein CIII levels in Patients With Lipodystrophy. J Clin Endocrinol Metab. 2016 04; 101(4):1790-7. PMID: 26900642; PMCID: PMC4880162.
    Citations: 4     Fields:    Translation:HumansAnimals
  21. Levenson AE, Haas ME, Miao J, Brown RJ, de Ferranti SD, Muniyappa R, Biddinger SB. Effect of Leptin Replacement on PCSK9 in ob/ob Mice and Female Lipodystrophic Patients. Endocrinology. 2016 Apr; 157(4):1421-9. PMID: 26824363; PMCID: PMC4816729.
    Citations: 7     Fields:    Translation:HumansAnimals
  22. Sun X, Haas ME, Miao J, Mehta A, Graham MJ, Crooke RM, Pais de Barros JP, Wang JG, Aikawa M, Masson D, Biddinger SB. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem. 2016 Jan 15; 291(3):1115-22. PMID: 26511317.
    Citations: 10     Fields:    Translation:AnimalsCells
  23. Miao J, Manthena PV, Haas ME, Ling AV, Shin DJ, Graham MJ, Crooke RM, Liu J, Biddinger SB. Role of Insulin in the Regulation of Proprotein Convertase Subtilisin/Kexin Type 9. Arterioscler Thromb Vasc Biol. 2015 Jul; 35(7):1589-96. PMID: 26023080; PMCID: PMC4484737.
    Citations: 35     Fields:    Translation:AnimalsCells
  24. Miao J, Ling AV, Manthena PV, Gearing ME, Graham MJ, Crooke RM, Croce KJ, Esquejo RM, Clish CB, Vicent D, Biddinger SB. Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun. 2015 Apr 07; 6:6498. PMID: 25849138.
    Citations: 146     Fields:    Translation:HumansAnimalsCells
  25. Kim DK, Kim YH, Hynx D, Wang Y, Yang KJ, Ryu D, Kim KS, Yoo EK, Kim JS, Koo SH, Lee IK, Chae HZ, Park J, Lee CH, Biddinger SB, Hemmings BA, Choi HS. PKB/Akt phosphorylation of ERR? contributes to insulin-mediated inhibition of hepatic gluconeogenesis. Diabetologia. 2014 Dec; 57(12):2576-85. PMID: 25205222.
    Citations: 16     Fields:    Translation:AnimalsCells
  26. Kurtz CL, Peck BC, Fannin EE, Beysen C, Miao J, Landstreet SR, Ding S, Turaga V, Lund PK, Turner S, Biddinger SB, Vickers KC, Sethupathy P. MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes. Diabetes. 2014 Sep; 63(9):3141-8. PMID: 24722248; PMCID: PMC4141370.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  27. Miao J, Haas JT, Manthena P, Wang Y, Zhao E, Vaitheesvaran B, Kurland IJ, Biddinger SB. Hepatic insulin receptor deficiency impairs the SREBP-2 response to feeding and statins. J Lipid Res. 2014 Apr; 55(4):659-67. PMID: 24516236.
    Citations: 20     Fields:    Translation:AnimalsCells
  28. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014 Jan 23; 505(7484):559-63. PMID: 24336217.
    Citations: 3430     Fields:    Translation:HumansCellsPHPublic HealthCTClinical Trials
  29. Haas ME, Attie AD, Biddinger SB. The regulation of ApoB metabolism by insulin. Trends Endocrinol Metab. 2013 Aug; 24(8):391-7. PMID: 23721961.
    Citations: 40     Fields:    Translation:HumansAnimals
  30. Haas JT, Miao J, Chanda D, Wang Y, Zhao E, Haas ME, Hirschey M, Vaitheesvaran B, Farese RV, Kurland IJ, Graham M, Crooke R, Foufelle F, Biddinger SB. Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. Cell Metab. 2012 Jun 06; 15(6):873-84. PMID: 22682225.
    Citations: 96     Fields:    Translation:AnimalsCells
  31. Bezy O, Tran TT, Pihlajamäki J, Suzuki R, Emanuelli B, Winnay J, Mori MA, Haas J, Biddinger SB, Leitges M, Goldfine AB, Patti ME, King GL, Kahn CR. PKCd regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun; 121(6):2504-17. PMID: 21576825; PMCID: PMC3104767.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  32. Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 2011 Mar; 17(3):356-65. PMID: 21317886.
    Citations: 145     Fields:    Translation:AnimalsCells
  33. Caron S, Verrijken A, Mertens I, Samanez CH, Mautino G, Haas JT, Duran-Sandoval D, Prawitt J, Francque S, Vallez E, Muhr-Tailleux A, Berard I, Kuipers F, Kuivenhoven JA, Biddinger SB, Taskinen MR, Van Gaal L, Staels B. Transcriptional activation of apolipoprotein CIII expression by glucose may contribute to diabetic dyslipidemia. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):513-9. PMID: 21183731.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  34. Suzuki R, Lee K, Jing E, Biddinger SB, McDonald JG, Montine TJ, Craft S, Kahn CR. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab. 2010 Dec 01; 12(6):567-79. PMID: 21109190.
    Citations: 75     Fields:    Translation:AnimalsCells
  35. Wang Y, Ziogas DC, Biddinger S, Kokkotou E. You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice. Gut. 2010 Dec; 59(12):1625-34. PMID: 20966023; PMCID: PMC3056117.
    Citations: 8     Fields:    Translation:AnimalsCells
  36. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 04; 464(7285):121-5. PMID: 20203611; PMCID: PMC2841477.
    Citations: 778     Fields:    Translation:HumansAnimalsCells
  37. Haas JT, Biddinger SB. Dissecting the role of insulin resistance in the metabolic syndrome. Curr Opin Lipidol. 2009 Jun; 20(3):206-10. PMID: 19421055.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  38. Biddinger S and Emanuelli B. Insulin Resistance in Obesity (in press). Metabolic Basis of Obesity. 2009.
  39. Kuipers F, Groen AK. Chipping away at gallstones. Nat Med. 2008 Jul; 14(7):715-6. PMID: 18607368.
    Citations: 1     Fields:    Translation:HumansAnimals
  40. Biddinger SB, Haas JT, Yu BB, Bezy O, Jing E, Zhang W, Unterman TG, Carey MC, Kahn CR. Hepatic insulin resistance directly promotes formation of cholesterol gallstones. Nat Med. 2008 Jul; 14(7):778-82. PMID: 18587407.
    Citations: 114     Fields:    Translation:Animals
  41. Scapa EF, Pocai A, Wu MK, Gutierrez-Juarez R, Glenz L, Kanno K, Li H, Biddinger S, Jelicks LA, Rossetti L, Cohen DE. Regulation of energy substrate utilization and hepatic insulin sensitivity by phosphatidylcholine transfer protein/StarD2. FASEB J. 2008 Jul; 22(7):2579-90. PMID: 18347010.
    Citations: 21     Fields:    Translation:AnimalsCells
  42. Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR. Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis. Cell Metab. 2008 Feb; 7(2):125-34. PMID: 18249172.
    Citations: 219     Fields:    Translation:Animals
  43. Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 2008 Feb; 7(2):95-6. PMID: 18249166.
    Citations: 424     Fields:    Translation:AnimalsCells
  44. Cohen SE, Kokkotou E, Biddinger SB, Kondo T, Gebhardt R, Kratzsch J, Mantzoros CS, Kahn CR. High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice. J Biol Chem. 2007 Aug 10; 282(32):23672-8. PMID: 17556363.
    Citations: 29     Fields:    Translation:AnimalsCells
  45. Biddinger SB, Miyazaki M, Boucher J, Ntambi JM, Kahn CR. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes. 2006 Jul; 55(7):2032-41. PMID: 16804073.
    Citations: 39     Fields:    Translation:AnimalsCells
  46. Biddinger SB, Kahn CR. From mice to men: insights into the insulin resistance syndromes. Annu Rev Physiol. 2006; 68:123-58. PMID: 16460269.
    Citations: 281     Fields:    Translation:HumansAnimalsCells
  47. Biddinger SB, Ludwig DS. The insulin-like growth factor axis: a potential link between glycemic index and cancer. Am J Clin Nutr. 2005 Aug; 82(2):277-8. PMID: 16087968.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  48. Biddinger SB, Almind K, Miyazaki M, Kokkotou E, Ntambi JM, Kahn CR. Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome. Diabetes. 2005 May; 54(5):1314-23. PMID: 15855315.
    Citations: 114     Fields:    Translation:Animals
  49. Balasubramanian S, Huganir RL. Characterization of phosphotyrosine containing proteins at the cholinergic synapse. FEBS Lett. 1999; 446(1):95-102.
  50. Balasubramanian S, Fung ET, Huganir RL . Characterization of the tyrosine phosphorylation and distribution of dystrobrevin isoforms. FEBS Lett. 1998; 432(3):133-40.
  51. Gillespie SK, Balasubramanian S, Fung ET, Huganir RL. Rapsyn clusters and activates the synapse-specific receptor tyrosine kinase MuSK. Neuron. 1996; 16(5):953-62.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.