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W. Allan Walker, M.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50GM021700 (TOMPKINS, RONALD GARY) Dec 1, 1977 - Nov 30, 2002
    Overall Application: Burn Trauma Center
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Su CW, Chen CY, Li Y, Long SR, Massey W, Kumar DV, Walker WA, Shi HN. Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages. Sci Rep. 2018 03 15; 8(1):4607. PMID: 29545532.
    Citations: 7     Fields:    Translation:AnimalsCells
  2. Walker WA. The importance of appropriate initial bacterial colonization of the intestine in newborn, child, and adult health. Pediatr Res. 2017 Sep; 82(3):387-395. PMID: 28426649.
    Citations: 19     Fields:    Translation:HumansCells
  3. Walker WA. Bacterial Colonization of the Newborn Gut, Immune Development, and Prevention of Disease. Nestle Nutr Inst Workshop Ser. 2017; 88:23-33. PMID: 28346921.
    Citations: 2     Fields:    Translation:HumansCells
  4. Gregory KE, Samuel BS, Houghteling P, Shan G, Ausubel FM, Sadreyev RI, Walker WA. Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants. Microbiome. 2016 12 30; 4(1):68. PMID: 28034306.
    Citations: 29     Fields:    Translation:HumansCells
  5. Guo S, Gillingham T, Guo Y, Meng D, Zhu W, Walker WA, Ganguli K. Secretions of Bifiodobacterium Infantis and Lactobacillus Acidophilus Protect Intestinal Epithelial Barrier Function. J Pediatr Gastroenterol Nutr. 2016 Jun 17. PMID: 27322557.
    Citations:    Fields:    
  6. Cahill CM, Zhu W, Oziolor E, Yang YJ, Tam B, Rajanala S, Rogers JT, Walker WA. Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte. PLoS One. 2016; 11(1):e0145184. PMID: 26799482.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  7. Houghteling PD, Walker WA. From Birth to "Immunohealth," Allergies and Enterocolitis. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S7-S12. PMID: 26447970.
    Citations: 4     Fields:    Translation:Humans
  8. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS, Brenner DA, Qamar AA, Miloh TA, Guarino A, Guslandi M, Dieleman LA, Ringel Y, Quigley EM, Brandt LJ. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S69-73. PMID: 26447969.
    Citations: 18     Fields:    Translation:HumansCells
  9. Floch MH, Walker WA. Introduction. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S1. PMID: 26447956.
  10. Guo S, Guo Y, Ergun A, Lu L, Walker WA, Ganguli K. Secreted Metabolites of Bifidobacterium infantis and Lactobacillus acidophilus Protect Immature Human Enterocytes from IL-1ß-Induced Inflammation: A Transcription Profiling Analysis. PLoS One. 2015; 10(4):e0124549. PMID: 25906317.
    Citations: 10     Fields:    Translation:HumansCells
  11. Houghteling PD, Walker WA. Why is initial bacterial colonization of the intestine important to infants' and children's health? J Pediatr Gastroenterol Nutr. 2015 Mar; 60(3):294-307. PMID: 25313849.
    Citations: 52     Fields:    Translation:HumansAnimals
  12. Weng M, Ganguli K, Zhu W, Shi HN, Walker WA. Conditioned medium from Bifidobacteria infantis protects against Cronobacter sakazakii-induced intestinal inflammation in newborn mice. Am J Physiol Gastrointest Liver Physiol. 2014 May 01; 306(9):G779-87. PMID: 24627567.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  13. Walker WA. Initial intestinal colonization in the human infant and immune homeostasis. Ann Nutr Metab. 2013; 63 Suppl 2:8-15. PMID: 24217032.
    Citations: 37     Fields:    Translation:HumansCells
  14. Bienenstock J, Gibson G, Klaenhammer TR, Walker WA, Neish AS. New insights into probiotic mechanisms: a harvest from functional and metagenomic studies. Gut Microbes. 2013 Mar-Apr; 4(2):94-100. PMID: 23249742.
    Citations: 8     Fields:    Translation:HumansAnimals
  15. Ganguli K, Meng D, Rautava S, Lu L, Walker WA, Nanthakumar N. Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G132-41. PMID: 23139215.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  16. Walker WA. Current opinion in gastroenterology. Curr Opin Gastroenterol. 2012 Nov; 28(6):547-50. PMID: 23010683.
    Citations: 1     Fields:    Translation:Humans
  17. Ganguli K, Walker WA. Treatment of necrotizing enterocolitis with probiotics. Gastroenterol Clin North Am. 2012 Dec; 41(4):733-46. PMID: 23101684.
    Citations: 4     Fields:    Translation:Humans
  18. Su CW, Cao Y, Zhang M, Kaplan J, Su L, Fu Y, Walker WA, Xavier R, Cherayil BJ, Shi HN. Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages. J Immunol. 2012 Aug 01; 189(3):1459-66. PMID: 22732589.
    Citations: 19     Fields:    Translation:AnimalsCells
  19. Foye OT, Huang IF, Chiou CC, Walker WA, Shi HN. Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling. FEMS Immunol Med Microbiol. 2012 Aug; 65(3):467-80. PMID: 22524476.
    Citations: 19     Fields:    Translation:AnimalsCells
  20. Rautava S, Lu L, Nanthakumar NN, Dubert-Ferrandon A, Walker WA. TGF-ß2 induces maturation of immature human intestinal epithelial cells and inhibits inflammatory cytokine responses induced via the NF-?B pathway. J Pediatr Gastroenterol Nutr. 2012 May; 54(5):630-8. PMID: 22067113.
    Citations: 16     Fields:    Translation:HumansCells
  21. Kaplan JL, Walker WA. Early gut colonization and subsequent obesity risk. Curr Opin Clin Nutr Metab Care. 2012 May; 15(3):278-84. PMID: 22327336.
    Citations: 5     Fields:    Translation:HumansAnimals
  22. Cahill CM, Rogers JT, Walker WA. The role of phosphoinositide 3-kinase signaling in intestinal inflammation. J Signal Transduct. 2012; 2012:358476. PMID: 22570785.
    Citations: 6     
  23. Ganguli K, Walker WA. Probiotics in the prevention of necrotizing enterocolitis. J Clin Gastroenterol. 2011 Nov; 45 Suppl:S133-8. PMID: 21992952.
    Citations: 22     Fields:    Translation:HumansCells
  24. Kaplan JL, Shi HN, Walker WA. The role of microbes in developmental immunologic programming. Pediatr Res. 2011 Jun; 69(6):465-72. PMID: 21364495.
    Citations: 53     Fields:    Translation:HumansAnimals
  25. Su CW, Cao Y, Kaplan J, Zhang M, Li W, Conroy M, Walker WA, Shi HN. Duodenal helminth infection alters barrier function of the colonic epithelium via adaptive immune activation. Infect Immun. 2011 Jun; 79(6):2285-94. PMID: 21444669.
    Citations: 16     Fields:    Translation:AnimalsCells
  26. Rautava S, Nanthakumar NN, Dubert-Ferrandon A, Lu L, Rautava J, Walker WA. Breast milk-transforming growth factor-ß2 specifically attenuates IL-1ß-induced inflammatory responses in the immature human intestine via an SMAD6- and ERK-dependent mechanism. Neonatology. 2011; 99(3):192-201. PMID: 20881435.
    Citations: 17     Fields:    Translation:HumansCells
  27. Walker WA. Mead Johnson Symposium: functional proteins in human milk: role in infant health and development. J Pediatr. 2010 Feb; 156(2 Suppl):S1-2. PMID: 20105658.
    Citations: 1     Fields:    Translation:Humans
  28. Walker A. Breast milk as the gold standard for protective nutrients. J Pediatr. 2010 Feb; 156(2 Suppl):S3-7. PMID: 20105662.
    Citations: 90     Fields:    Translation:HumansAnimals
  29. Walker WA, Sherman P, Shneider BL, Cohen M, Barnard J. State of research in pediatric gastroenterology, hepatology, and nutrition: 2010 and beyond. Gastroenterology. 2010 Feb; 138(2):411-6, 416.e1-2. PMID: 20025876.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  30. Sherman PM, Cabana M, Gibson GR, Koletzko BV, Neu J, Veereman-Wauters G, Ziegler EE, Walker WA. Potential roles and clinical utility of prebiotics in newborns, infants, and children: proceedings from a global prebiotic summit meeting, New York City, June 27-28, 2008. J Pediatr. 2009 Nov; 155(5):S61-70. PMID: 19840609.
    Citations: 14     Fields:    Translation:HumansCells
  31. Lu L, Khan A, Walker WA. ADP-ribosylation factors regulate the development of CT signaling in immature human enterocytes. Am J Physiol Gastrointest Liver Physiol. 2009 Jun; 296(6):G1221-9. PMID: 19359423.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  32. Rautava S, Walker WA. Academy of Breastfeeding Medicine founder's lecture 2008: breastfeeding--an extrauterine link between mother and child. Breastfeed Med. 2009 Mar; 4(1):3-10. PMID: 19292608.
    Citations: 20     Fields:    Translation:Humans
  33. Walker WA. Immunology section. Curr Opin Gastroenterol. 2008 Nov; 24(6):698-700. PMID: 19122518.
    Citations:    Fields:    Translation:HumansAnimals
  34. Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J Immunol. 2008 Aug 15; 181(4):2723-31. PMID: 18684963.
    Citations: 58     Fields:    Translation:AnimalsCells
  35. Martin CR, Walker WA. Probiotics: role in pathophysiology and prevention in necrotizing enterocolitis. Semin Perinatol. 2008 Apr; 32(2):127-37. PMID: 18346537.
    Citations: 30     Fields:    Translation:Humans
  36. Walker WA. Mechanisms of action of probiotics. Clin Infect Dis. 2008 Feb 01; 46 Suppl 2:S87-91; discussion S144-51. PMID: 18181730.
    Citations: 33     Fields:    Translation:HumansCells
  37. Conroy ME, Walker WA. Intestinal immune health. Nestle Nutr Workshop Ser Pediatr Program. 2008; 62:111-21; discussion 121-5. PMID: 18626196.
    Citations: 3     Fields:    Translation:HumansCells
  38. Vassallo MF, Walker WA. Neonatal microbial flora and disease outcome. Nestle Nutr Workshop Ser Pediatr Program. 2008; 61:211-24. PMID: 18196954.
    Citations: 7     Fields:    Translation:Humans
  39. Weng M, Walker WA, Sanderson IR. Butyrate regulates the expression of pathogen-triggered IL-8 in intestinal epithelia. Pediatr Res. 2007 Nov; 62(5):542-6. PMID: 17805211.
    Citations: 11     Fields:    Translation:HumansCells
  40. Weng M, Huntley D, Huang IF, Foye-Jackson O, Wang L, Sarkissian A, Zhou Q, Walker WA, Cherayil BJ, Shi HN. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J Immunol. 2007 Oct 01; 179(7):4721-31. PMID: 17878371.
    Citations: 56     Fields:    Translation:AnimalsCells
  41. Rautava S, Walker WA. Commensal bacteria and epithelial cross talk in the developing intestine. Curr Gastroenterol Rep. 2007 Oct; 9(5):385-92. PMID: 17991339.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  42. Zhou JR, Blackburn GL, Walker WA. Symposium introduction: metabolic syndrome and the onset of cancer. Am J Clin Nutr. 2007 09; 86(3):s817-9. PMID: 18265474.
    Citations: 20     Fields:    Translation:Humans
  43. Meng D, Newburg DS, Young C, Baker A, Tonkonogy SL, Sartor RB, Walker WA, Nanthakumar NN. Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling. Am J Physiol Gastrointest Liver Physiol. 2007 Oct; 293(4):G780-7. PMID: 17673542.
    Citations: 25     Fields:    Translation:AnimalsCells
  44. Broekaert IJ, Nanthakumar NN, Walker WA. Secreted probiotic factors ameliorate enteropathogenic infection in zinc-deficient human Caco-2 and T84 cell lines. Pediatr Res. 2007 Aug; 62(2):139-44. PMID: 17597654.
    Citations: 11     Fields:    Translation:HumansCells
  45. Newburg DS, Walker WA. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr Res. 2007 Jan; 61(1):2-8. PMID: 17211132.
    Citations: 132     Fields:    Translation:Humans
  46. Walker WA, Sherman P, Cohen M, Barnard J. State of pediatric gastroenterology, hepatology, and nutrition: 2006 and beyond. Gastroenterology. 2007 Jan; 132(1):434-6. PMID: 17241890.
    Citations:    Fields:    Translation:Humans
  47. Broekaert IJ, Walker WA. Probiotics and chronic disease. J Clin Gastroenterol. 2006 Mar; 40(3):270-4. PMID: 16633135.
    Citations: 10     Fields:    Translation:Humans
  48. Broekaert IJ, Walker WA. Probiotics as flourishing benefactors for the human body. Gastroenterol Nurs. 2006 Jan-Feb; 29(1):26-34. PMID: 16552297.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  49. Savidge TC, Newman PG, Pan WH, Weng MQ, Shi HN, McCormick BA, Quaroni A, Walker WA. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. Pediatr Res. 2006 Jan; 59(1):89-95. PMID: 16326999.
    Citations: 12     Fields:    Translation:HumansCells
  50. Rhee SJ, Walker WA, Cherayil BJ. Developmentally regulated intestinal expression of IFN-gamma and its target genes and the age-specific response to enteric Salmonella infection. J Immunol. 2005 Jul 15; 175(2):1127-36. PMID: 16002714.
    Citations: 39     Fields:    Translation:AnimalsCells
  51. Yuan Q, Walker WA. Worm therapy for ulcerative colitis: a possible link to regulatory T cells. J Pediatr Gastroenterol Nutr. 2005 Jul; 41(1):139-40. PMID: 15990650.
    Citations:    Fields:    Translation:HumansAnimalsCells
  52. Blackburn GL, Walker WA. Science-based solutions to obesity: what are the roles of academia, government, industry, and health care? Am J Clin Nutr. 2005 07; 82(1 Suppl):207S-210S. PMID: 16002821.
    Citations: 8     Fields:    Translation:Humans
  53. Lu L, Khan S, Lencer W, Walker WA. Endocytosis of cholera toxin by human enterocytes is developmentally regulated. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G332-41. PMID: 15790757.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  54. Nanthakumar NN, Young C, Ko JS, Meng D, Chen J, Buie T, Walker WA. Glucocorticoid responsiveness in developing human intestine: possible role in prevention of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005 Jan; 288(1):G85-92. PMID: 15591589.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  55. Nanthakumar NN, Dai D, Meng D, Chaudry N, Newburg DS, Walker WA. Regulation of intestinal ontogeny: effect of glucocorticoids and luminal microbes on galactosyltransferase and trehalase induction in mice. Glycobiology. 2005 Mar; 15(3):221-32. PMID: 15483270.
    Citations: 11     Fields:    Translation:Animals
  56. Huang FC, Werne A, Li Q, Galyov EE, Walker WA, Cherayil BJ. Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection. Infect Immun. 2004 Sep; 72(9):5052-62. PMID: 15321998.
    Citations: 18     Fields:    Translation:HumansCells
  57. Walker WA, Blackburn G. Symposium introduction: nutrition and gene regulation. J Nutr. 2004 Sep; 134(9):2434S-2436S. PMID: 15333738.
    Citations: 7     Fields:    Translation:HumansAnimals
  58. Yuan Q, Walker WA. Innate immunity of the gut: mucosal defense in health and disease. J Pediatr Gastroenterol Nutr. 2004 May; 38(5):463-73. PMID: 15097431.
    Citations: 16     Fields:    Translation:Humans
  59. Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7404-8. PMID: 15123821.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  60. Walker WA. The dynamic effects of breastfeeding on intestinal development and host defense. Adv Exp Med Biol. 2004; 554:155-70. PMID: 15384575.
    Citations: 13     Fields:    Translation:Humans
  61. Lu L, Baldeon ME, Savidge T, Pothoulakis C, Walker WA. Development of microbial-human enterocyte interaction: cholera toxin. Pediatr Res. 2003 Aug; 54(2):212-8. PMID: 12736381.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  62. Köhler H, McCormick BA, Walker WA. Bacterial-enterocyte crosstalk: cellular mechanisms in health and disease. J Pediatr Gastroenterol Nutr. 2003 Feb; 36(2):175-85. PMID: 12548051.
    Citations: 8     Fields:    Translation:HumansCells
  63. Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, Walker WA. Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine. Pediatr Res. 2003 Feb; 53(2):295-301. PMID: 12538789.
    Citations: 38     Fields:    Translation:HumansCells
  64. Walker WA. Innovative teaching strategies for training physicians in clinical nutrition: an overview. J Nutr. 2003 Feb; 133(2):541S-3S. PMID: 12566498.
    Citations: 7     Fields:    Translation:Humans
  65. Nanthakumar NN, Klopcic CE, Fernandez I, Walker WA. Normal and glucocorticoid-induced development of the human small intestinal xenograft. . 2003 Jul; 285(1):R162-70. PMID: 12560204.
    Citations: 12     Translation:HumansAnimals
  66. Nanthakumar NN, Dai D, Newburg DS, Walker WA. The role of indigenous microflora in the development of murine intestinal fucosyl- and sialyltransferases. FASEB J. 2003 Jan; 17(1):44-6. PMID: 12475916.
    Citations: 15     Fields:    Translation:AnimalsCells
  67. Shi HN, Walker WA. T helper cell subclasses and clinical disease states. Curr Opin Gastroenterol. 2002 Nov; 18(6):711-6. PMID: 17033353.
    Citations:    Fields:    
  68. Duggan C, Gannon J, Walker WA. Protective nutrients and functional foods for the gastrointestinal tract. Am J Clin Nutr. 2002 May; 75(5):789-808. PMID: 11976152.
    Citations: 27     Fields:    Translation:HumansAnimals
  69. Walker WA. Development of the intestinal mucosal barrier. J Pediatr Gastroenterol Nutr. 2002 May-Jun; 34 Suppl 1:S33-9. PMID: 12082386.
    Citations: 18     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.