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profileW. Allan Walker, M.D.

TitleConrad Taff Professor of Pediatrics
InstitutionMassachusetts General Hospital
DepartmentPediatrics
AddressHarvard Medical School
Division of Nutrition, MEC384
260 Longwood Ave
Boston MA 02115
Phone617/726-7988
Fax617/724-1731
vCardDownload vCard (login for email)
Other Positions
TitleProfessor in the Department of Nutrition
InstitutionHarvard T.H. Chan School of Public Health
DepartmentNutrition


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
P50GM021700     (TOMPKINS, RONALD GARY)Dec 1, 1977 - May 31, 2018
NIH/NIGMS
Overall Application: Burn Trauma Center
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Walker WA. The importance of appropriate initial bacterial colonization of the intestine in newborn, child, and adult health. Pediatr Res. 2017 Sep; 82(3):387-395. PMID: 28426649.
    View in: PubMed
  2. Walker WA. Bacterial Colonization of the Newborn Gut, Immune Development, and Prevention of Disease. Nestle Nutr Inst Workshop Ser. 2017; 88:23-33. PMID: 28346921.
    View in: PubMed
  3. Guo S, Gillingham T, Guo Y, Meng D, Zhu W, Walker WA, Ganguli K. Secretions of Bifiodobacterium Infantis and Lactobacillus Acidophilus Protect Intestinal Epithelial Barrier Function. J Pediatr Gastroenterol Nutr. 2016 Jun 17. PMID: 27322557.
    View in: PubMed
  4. Cahill CM, Zhu W, Oziolor E, Yang YJ, Tam B, Rajanala S, Rogers JT, Walker WA. Differential Expression of the Activator Protein 1 Transcription Factor Regulates Interleukin-1ß Induction of Interleukin 6 in the Developing Enterocyte. PLoS One. 2016; 11(1):e0145184. PMID: 26799482; PMCID: PMC4723075.
  5. Houghteling PD, Walker WA. From Birth to "Immunohealth," Allergies and Enterocolitis. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S7-S12. PMID: 26447970; PMCID: PMC4602161 [Available on 11/01/16].
  6. Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS, Brenner DA, Qamar AA, Miloh TA, Guarino A, Guslandi M, Dieleman LA, Ringel Y, Quigley EM, Brandt LJ. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S69-73. PMID: 26447969.
    View in: PubMed
  7. Floch MH, Walker WA. Introduction. J Clin Gastroenterol. 2015 Nov-Dec; 49 Suppl 1:S1. PMID: 26447956.
    View in: PubMed
  8. Guo S, Guo Y, Ergun A, Lu L, Walker WA, Ganguli K. Secreted Metabolites of Bifidobacterium infantis and Lactobacillus acidophilus Protect Immature Human Enterocytes from IL-1ß-Induced Inflammation: A Transcription Profiling Analysis. PLoS One. 2015; 10(4):e0124549. PMID: 25906317; PMCID: PMC4407962.
  9. Houghteling PD, Walker WA. Why is initial bacterial colonization of the intestine important to infants' and children's health? J Pediatr Gastroenterol Nutr. 2015 Mar; 60(3):294-307. PMID: 25313849; PMCID: PMC4340742.
  10. Weng M, Ganguli K, Zhu W, Shi HN, Walker WA. Conditioned medium from Bifidobacteria infantis protects against Cronobacter sakazakii-induced intestinal inflammation in newborn mice. Am J Physiol Gastrointest Liver Physiol. 2014 May 01; 306(9):G779-87. PMID: 24627567; PMCID: PMC4010653.
  11. Walker WA. Initial intestinal colonization in the human infant and immune homeostasis. Ann Nutr Metab. 2013; 63 Suppl 2:8-15. PMID: 24217032.
    View in: PubMed
  12. Bienenstock J, Gibson G, Klaenhammer TR, Walker WA, Neish AS. New insights into probiotic mechanisms: a harvest from functional and metagenomic studies. Gut Microbes. 2013 Mar-Apr; 4(2):94-100. PMID: 23249742; PMCID: PMC3595083.
  13. Ganguli K, Meng D, Rautava S, Lu L, Walker WA, Nanthakumar N. Probiotics prevent necrotizing enterocolitis by modulating enterocyte genes that regulate innate immune-mediated inflammation. Am J Physiol Gastrointest Liver Physiol. 2013 Jan 15; 304(2):G132-41. PMID: 23139215; PMCID: PMC3543644.
  14. Walker WA. Current opinion in gastroenterology. Curr Opin Gastroenterol. 2012 Nov; 28(6):547-50. PMID: 23010683.
    View in: PubMed
  15. Ganguli K, Walker WA. Treatment of necrotizing enterocolitis with probiotics. Gastroenterol Clin North Am. 2012 Dec; 41(4):733-46. PMID: 23101684.
    View in: PubMed
  16. Su CW, Cao Y, Zhang M, Kaplan J, Su L, Fu Y, Walker WA, Xavier R, Cherayil BJ, Shi HN. Helminth infection impairs autophagy-mediated killing of bacterial enteropathogens by macrophages. J Immunol. 2012 Aug 01; 189(3):1459-66. PMID: 22732589; PMCID: PMC3423331.
  17. Foye OT, Huang IF, Chiou CC, Walker WA, Shi HN. Early administration of probiotic Lactobacillus acidophilus and/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling. FEMS Immunol Med Microbiol. 2012 Aug; 65(3):467-80. PMID: 22524476; PMCID: PMC4015462.
  18. Rautava S, Lu L, Nanthakumar NN, Dubert-Ferrandon A, Walker WA. TGF-ß2 induces maturation of immature human intestinal epithelial cells and inhibits inflammatory cytokine responses induced via the NF-?B pathway. J Pediatr Gastroenterol Nutr. 2012 May; 54(5):630-8. PMID: 22067113; PMCID: PMC3319014.
  19. Kaplan JL, Walker WA. Early gut colonization and subsequent obesity risk. Curr Opin Clin Nutr Metab Care. 2012 May; 15(3):278-84. PMID: 22327336.
    View in: PubMed
  20. Cahill CM, Rogers JT, Walker WA. The role of phosphoinositide 3-kinase signaling in intestinal inflammation. J Signal Transduct. 2012; 2012:358476. PMID: 22570785; PMCID: PMC3337621.
  21. Ganguli K, Walker WA. Probiotics in the prevention of necrotizing enterocolitis. J Clin Gastroenterol. 2011 Nov; 45 Suppl:S133-8. PMID: 21992952.
    View in: PubMed
  22. Kaplan JL, Shi HN, Walker WA. The role of microbes in developmental immunologic programming. Pediatr Res. 2011 Jun; 69(6):465-72. PMID: 21364495.
    View in: PubMed
  23. Su CW, Cao Y, Kaplan J, Zhang M, Li W, Conroy M, Walker WA, Shi HN. Duodenal helminth infection alters barrier function of the colonic epithelium via adaptive immune activation. Infect Immun. 2011 Jun; 79(6):2285-94. PMID: 21444669; PMCID: PMC3125859.
  24. Rautava S, Nanthakumar NN, Dubert-Ferrandon A, Lu L, Rautava J, Walker WA. Breast milk-transforming growth factor-ß2 specifically attenuates IL-1ß-induced inflammatory responses in the immature human intestine via an SMAD6- and ERK-dependent mechanism. Neonatology. 2011; 99(3):192-201. PMID: 20881435; PMCID: PMC3214931.
  25. Walker WA. Mead Johnson Symposium: functional proteins in human milk: role in infant health and development. J Pediatr. 2010 Feb; 156(2 Suppl):S1-2. PMID: 20105658.
    View in: PubMed
  26. Walker A. Breast milk as the gold standard for protective nutrients. J Pediatr. 2010 Feb; 156(2 Suppl):S3-7. PMID: 20105662.
    View in: PubMed
  27. Walker WA, Sherman P, Shneider BL, Cohen M, Barnard J. State of research in pediatric gastroenterology, hepatology, and nutrition: 2010 and beyond. Gastroenterology. 2010 Feb; 138(2):411-6, 416.e1-2. PMID: 20025876.
    View in: PubMed
  28. Sherman PM, Cabana M, Gibson GR, Koletzko BV, Neu J, Veereman-Wauters G, Ziegler EE, Walker WA. Potential roles and clinical utility of prebiotics in newborns, infants, and children: proceedings from a global prebiotic summit meeting, New York City, June 27-28, 2008. J Pediatr. 2009 Nov; 155(5):S61-70. PMID: 19840609.
    View in: PubMed
  29. Lu L, Khan A, Walker WA. ADP-ribosylation factors regulate the development of CT signaling in immature human enterocytes. Am J Physiol Gastrointest Liver Physiol. 2009 Jun; 296(6):G1221-9. PMID: 19359423; PMCID: PMC2697949.
  30. Rautava S, Walker WA. Academy of Breastfeeding Medicine founder's lecture 2008: breastfeeding--an extrauterine link between mother and child. Breastfeed Med. 2009 Mar; 4(1):3-10. PMID: 19292608; PMCID: PMC2932545.
  31. Walker WA. Immunology section. Curr Opin Gastroenterol. 2008 Nov; 24(6):698-700. PMID: 19122518.
    View in: PubMed
  32. Wang L, Johnson EE, Shi HN, Walker WA, Wessling-Resnick M, Cherayil BJ. Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation. J Immunol. 2008 Aug 15; 181(4):2723-31. PMID: 18684963; PMCID: PMC2561261.
  33. Martin CR, Walker WA. Probiotics: role in pathophysiology and prevention in necrotizing enterocolitis. Semin Perinatol. 2008 Apr; 32(2):127-37. PMID: 18346537.
    View in: PubMed
  34. Walker WA. Mechanisms of action of probiotics. Clin Infect Dis. 2008 Feb 01; 46 Suppl 2:S87-91; discussion S144-51. PMID: 18181730.
    View in: PubMed
  35. Conroy ME, Walker WA. Intestinal immune health. Nestle Nutr Workshop Ser Pediatr Program. 2008; 62:111-21; discussion 121-5. PMID: 18626196.
    View in: PubMed
  36. Vassallo MF, Walker WA. Neonatal microbial flora and disease outcome. Nestle Nutr Workshop Ser Pediatr Program. 2008; 61:211-24. PMID: 18196954.
    View in: PubMed
  37. Weng M, Walker WA, Sanderson IR. Butyrate regulates the expression of pathogen-triggered IL-8 in intestinal epithelia. Pediatr Res. 2007 Nov; 62(5):542-6. PMID: 17805211; PMCID: PMC3201723.
  38. Weng M, Huntley D, Huang IF, Foye-Jackson O, Wang L, Sarkissian A, Zhou Q, Walker WA, Cherayil BJ, Shi HN. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J Immunol. 2007 Oct 01; 179(7):4721-31. PMID: 17878371; PMCID: PMC3208515.
  39. Rautava S, Walker WA. Commensal bacteria and epithelial cross talk in the developing intestine. Curr Gastroenterol Rep. 2007 Oct; 9(5):385-92. PMID: 17991339; PMCID: PMC3208513.
  40. Zhou JR, Blackburn GL, Walker WA. Symposium introduction: metabolic syndrome and the onset of cancer. Am J Clin Nutr. 2007 Sep; 86(3):s817-9. PMID: 18265474; PMCID: PMC4144325.
  41. Meng D, Newburg DS, Young C, Baker A, Tonkonogy SL, Sartor RB, Walker WA, Nanthakumar NN. Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling. Am J Physiol Gastrointest Liver Physiol. 2007 Oct; 293(4):G780-7. PMID: 17673542.
    View in: PubMed
  42. Broekaert IJ, Nanthakumar NN, Walker WA. Secreted probiotic factors ameliorate enteropathogenic infection in zinc-deficient human Caco-2 and T84 cell lines. Pediatr Res. 2007 Aug; 62(2):139-44. PMID: 17597654.
    View in: PubMed
  43. Newburg DS, Walker WA. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr Res. 2007 Jan; 61(1):2-8. PMID: 17211132.
    View in: PubMed
  44. Walker WA, Sherman P, Cohen M, Barnard J. State of pediatric gastroenterology, hepatology, and nutrition: 2006 and beyond. Gastroenterology. 2007 Jan; 132(1):434-6. PMID: 17241890.
    View in: PubMed
  45. Broekaert IJ, Walker WA. Probiotics and chronic disease. J Clin Gastroenterol. 2006 Mar; 40(3):270-4. PMID: 16633135.
    View in: PubMed
  46. Broekaert IJ, Walker WA. Probiotics as flourishing benefactors for the human body. Gastroenterol Nurs. 2006 Jan-Feb; 29(1):26-34. PMID: 16552297.
    View in: PubMed
  47. Savidge TC, Newman PG, Pan WH, Weng MQ, Shi HN, McCormick BA, Quaroni A, Walker WA. Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. Pediatr Res. 2006 Jan; 59(1):89-95. PMID: 16326999; PMCID: PMC4465784.
  48. Rhee SJ, Walker WA, Cherayil BJ. Developmentally regulated intestinal expression of IFN-gamma and its target genes and the age-specific response to enteric Salmonella infection. J Immunol. 2005 Jul 15; 175(2):1127-36. PMID: 16002714.
    View in: PubMed
  49. Yuan Q, Walker WA. Worm therapy for ulcerative colitis: a possible link to regulatory T cells. J Pediatr Gastroenterol Nutr. 2005 Jul; 41(1):139-40. PMID: 15990650.
    View in: PubMed
  50. Blackburn GL, Walker WA. Science-based solutions to obesity: what are the roles of academia, government, industry, and health care? Am J Clin Nutr. 2005 Jul; 82(1 Suppl):207S-210S. PMID: 16002821.
    View in: PubMed
  51. Lu L, Khan S, Lencer W, Walker WA. Endocytosis of cholera toxin by human enterocytes is developmentally regulated. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G332-41. PMID: 15790757.
    View in: PubMed
  52. Nanthakumar NN, Young C, Ko JS, Meng D, Chen J, Buie T, Walker WA. Glucocorticoid responsiveness in developing human intestine: possible role in prevention of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol. 2005 Jan; 288(1):G85-92. PMID: 15591589.
    View in: PubMed
  53. Nanthakumar NN, Dai D, Meng D, Chaudry N, Newburg DS, Walker WA. Regulation of intestinal ontogeny: effect of glucocorticoids and luminal microbes on galactosyltransferase and trehalase induction in mice. Glycobiology. 2005 Mar; 15(3):221-32. PMID: 15483270.
    View in: PubMed
  54. Huang FC, Werne A, Li Q, Galyov EE, Walker WA, Cherayil BJ. Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection. Infect Immun. 2004 Sep; 72(9):5052-62. PMID: 15321998; PMCID: PMC517448.
  55. Walker WA, Blackburn G. Symposium introduction: nutrition and gene regulation. J Nutr. 2004 Sep; 134(9):2434S-2436S. PMID: 15333738.
    View in: PubMed
  56. Yuan Q, Walker WA. Innate immunity of the gut: mucosal defense in health and disease. J Pediatr Gastroenterol Nutr. 2004 May; 38(5):463-73. PMID: 15097431.
    View in: PubMed
  57. Claud EC, Lu L, Anton PM, Savidge T, Walker WA, Cherayil BJ. Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7404-8. PMID: 15123821; PMCID: PMC409931.
  58. Walker WA. The dynamic effects of breastfeeding on intestinal development and host defense. Adv Exp Med Biol. 2004; 554:155-70. PMID: 15384575.
    View in: PubMed
  59. Lu L, Baldeon ME, Savidge T, Pothoulakis C, Walker WA. Development of microbial-human enterocyte interaction: cholera toxin. Pediatr Res. 2003 Aug; 54(2):212-8. PMID: 12736381.
    View in: PubMed
  60. Köhler H, McCormick BA, Walker WA. Bacterial-enterocyte crosstalk: cellular mechanisms in health and disease. J Pediatr Gastroenterol Nutr. 2003 Feb; 36(2):175-85. PMID: 12548051.
    View in: PubMed
  61. Shah U, Dickinson BL, Blumberg RS, Simister NE, Lencer WI, Walker WA. Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine. Pediatr Res. 2003 Feb; 53(2):295-301. PMID: 12538789; PMCID: PMC2819091.
  62. Walker WA. Innovative teaching strategies for training physicians in clinical nutrition: an overview. J Nutr. 2003 Feb; 133(2):541S-3S. PMID: 12566498.
    View in: PubMed
  63. Nanthakumar NN, Klopcic CE, Fernandez I, Walker WA. Normal and glucocorticoid-induced development of the human small intestinal xenograft. Am J Physiol Regul Integr Comp Physiol. 2003 Jul; 285(1):R162-70. PMID: 12560204.
    View in: PubMed
  64. Nanthakumar NN, Dai D, Newburg DS, Walker WA. The role of indigenous microflora in the development of murine intestinal fucosyl- and sialyltransferases. FASEB J. 2003 Jan; 17(1):44-6. PMID: 12475916.
    View in: PubMed
  65. Shi HN, Walker WA. T helper cell subclasses and clinical disease states. Curr Opin Gastroenterol. 2002 Nov; 18(6):711-6. PMID: 17033353.
    View in: PubMed
  66. Duggan C, Gannon J, Walker WA. Protective nutrients and functional foods for the gastrointestinal tract. Am J Clin Nutr. 2002 May; 75(5):789-808. PMID: 11976152.
    View in: PubMed
  67. Walker WA. Development of the intestinal mucosal barrier. J Pediatr Gastroenterol Nutr. 2002 May-Jun; 34 Suppl 1:S33-9. PMID: 12082386.
    View in: PubMed
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