Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jeffrey Joseph Fredberg, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL148152 (FREDBERG, JEFFREY J) Aug 15, 2019 - Apr 30, 2023
    Physics of bronchial epithelial unjamming
    Role: Principal Investigator
  2. U01CA202123 (FREDBERG, JEFFREY J) Sep 23, 2015 - Aug 31, 2020
    Epithelial layer jamming in breast cancer cell migration
    Role: Principal Investigator
  3. P01HL120839 (FREDBERG, JEFFREY J) Aug 1, 2014 - Jun 30, 2019
    Physics of collective cellular migration in lung health and disease
    Role: Principal Investigator
  4. P50HL107171 (SOLWAY, JULIAN) May 1, 2011 - Apr 30, 2014
    Therapeutic Potentiation of Bronchial Dilatation
    Role: Principal Investigator
  5. R01HL107561 (FREDBERG, JEFFREY J) Apr 6, 2011 - Mar 31, 2016
    Mechanics of Monolayer Migration
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kiliç A, Ameli A, Park JA, Kho AT, Tantisira K, Santolini M, Cheng F, Mitchel JA, McGill M, O'Sullivan MJ, De Marzio M, Sharma A, Randell SH, Drazen JM, Fredberg JJ, Weiss ST. Mechanical forces induce an asthma gene signature in healthy airway epithelial cells. Sci Rep. 2020 Jan 22; 10(1):966. PMID: 31969610.
  2. Gazzola M, Henry C, Lortie K, Khadangi F, Park CY, Fredberg JJ, Bossé Y. Airway smooth muscle tone increases actin filamentogenesis and contractile capacity. Am J Physiol Lung Cell Mol Physiol. 2020 02 01; 318(2):L442-L451. PMID: 31850799.
  3. Kim JH, Pegoraro AF, Das A, Koehler SA, Ujwary SA, Lan B, Mitchel JA, Atia L, He S, Wang K, Bi D, Zaman MH, Park JA, Butler JP, Lee KH, Starr JR, Fredberg JJ. Unjamming and collective migration in MCF10A breast cancer cell lines. Biochem Biophys Res Commun. 2020 Jan 15; 521(3):706-715. PMID: 31699371.
  4. Jang H, Kim J, Shin JH, Fredberg JJ, Park CY, Park Y. Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration. J Vis Exp. 2019 10 13; (152). PMID: 31657799.
  5. Patel G, Xu N, Nguyen A, Alvarez DF, Fredberg JJ, Stevens T, Tambe DT. Mechanical signaling in a pulmonary microvascular endothelial cell monolayer. Biochem Biophys Res Commun. 2019 11 05; 519(2):337-343. PMID: 31514994.
  6. Reed EB, Ard S, La J, Park CY, Culligan L, Fredberg JJ, Smolyaninova LV, Orlov SN, Chen B, Guzy R, Mutlu GM, Dulin NO. Anti-fibrotic effects of tannic acid through regulation of a sustained TGF-beta receptor signaling. Respir Res. 2019 Jul 29; 20(1):168. PMID: 31358001.
  7. Jang H, Kim J, Shin JH, Fredberg JJ, Park CY, Park Y. Traction microscopy with integrated microfluidics: responses of the multi-cellular island to gradients of HGF. Lab Chip. 2019 04 23; 19(9):1579-1588. PMID: 30924490.
  8. Mandal K, Aroush DR, Graber ZT, Wu B, Park CY, Fredberg JJ, Guo W, Baumgart T, Janmey PA. Correction to Soft Hyaluronic Gels Promote Cell Spreading, Stress Fibers, Focal Adhesion, and Membrane Tension by Phosphoinositide Signaling, Not Traction Force. ACS Nano. 2019 Apr 23; 13(4):4854. PMID: 30883087.
  9. He S, Carman CV, Lee JH, Lan B, Koehler S, Atia L, Park CY, Kim JH, Mitchel JA, Park JA, Butler JP, Lu Q, Fredberg JJ. The tumor suppressor p53 can promote collective cellular migration. PLoS One. 2019; 14(2):e0202065. PMID: 30707705.
    Citations:    Fields:    
  10. Vahabikashi A, Park CY, Perkumas K, Zhang Z, Deurloo EK, Wu H, Weitz DA, Stamer WD, Goldman RD, Fredberg JJ, Johnson M. Probe Sensitivity to Cortical versus Intracellular Cytoskeletal Network Stiffness. Biophys J. 2019 02 05; 116(3):518-529. PMID: 30685055.
    Citations:    Fields:    
  11. Mandal K, Raz-Ben Aroush D, Graber ZT, Wu B, Park CY, Fredberg JJ, Guo W, Baumgart T, Janmey PA. Soft Hyaluronic Gels Promote Cell Spreading, Stress Fibers, Focal Adhesion, and Membrane Tension by Phosphoinositide Signaling, Not Traction Force. ACS Nano. 2019 01 22; 13(1):203-214. PMID: 30500159.
    Citations:    Fields:    
  12. Atia L, Bi D, Sharma Y, Mitchel JA, Gweon B, Koehler S, DeCamp SJ, Lan B, Kim JH, Hirsch R, Pegoraro AF, Lee KH, Starr JR, Weitz DA, Martin AC, Park JA, Butler JP, Fredberg JJ. Geometric constraints during epithelial jamming. Nat Phys. 2018 Jun; 14:613-620. PMID: 30151030.
    Citations: 1     
  13. Sharma Y, Atia L, Rhodes CS, DeCamp SJ, Mitchel J, Fredberg JJ. Scaling Physiologic Function from Cell to Tissue in Asthma, Cancer, and Development. Ann Am Thorac Soc. 2018 02; 15(Suppl 1):S35-S37. PMID: 29461895.
    Citations:    Fields:    
  14. Lan B, Krishnan R, Park CY, Watanabe RA, Panganiban R, Butler JP, Lu Q, Cole WC, Fredberg JJ. Transient stretch induces cytoskeletal fluidization through the severing action of cofilin. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L799-L807. PMID: 29345194.
    Citations:    Fields:    Translation:HumansCells
  15. Bhatawadekar SA, Keller G, Francisco CO, Inman MD, Fredberg JJ, Tarlo SM, Stanbrook M, Lyons OD, Yadollahi A. Reduced Baseline Airway Caliber Relates to Larger Airway Sensitivity to Rostral Fluid Shift in Asthma. Front Physiol. 2017; 8:1012. PMID: 29311954.
    Citations: 1     
  16. O'Sullivan MJ, Gabriel E, Panariti A, Park CY, Ijpma G, Fredberg JJ, Lauzon AM, Martin JG. Epithelial Cells Induce a Cyclo-Oxygenase-1-Dependent Endogenous Reduction in Airway Smooth Muscle Contractile Phenotype. Am J Respir Cell Mol Biol. 2017 12; 57(6):683-691. PMID: 28708434.
    Citations:    Fields:    Translation:HumansCells
  17. Hardin CC, Chattoraj J, Manomohan G, Colombo J, Nguyen T, Tambe D, Fredberg JJ, Birukov K, Butler JP, Del Gado E, Krishnan R. Long-range stress transmission guides endothelial gap formation. Biochem Biophys Res Commun. 2018 01 01; 495(1):749-754. PMID: 29137986.
    Citations:    Fields:    Translation:HumansCells
  18. Lee G, Atia L, Lan B, Sharma Y, Nissim L, Wu MR, Pery E, Lu TK, Park CY, Butler JP, Fredberg JJ. Contact guidance and collective migration in the advancing epithelial monolayer. Connect Tissue Res. 2018 07; 59(4):309-315. PMID: 28945485.
    Citations:    Fields:    
  19. Guo M, Pegoraro AF, Mao A, Zhou EH, Arany PR, Han Y, Burnette DT, Jensen MH, Kasza KE, Moore JR, Mackintosh FC, Fredberg JJ, Mooney DJ, Lippincott-Schwartz J, Weitz DA. Cell volume change through water efflux impacts cell stiffness and stem cell fate. Proc Natl Acad Sci U S A. 2017 10 10; 114(41):E8618-E8627. PMID: 28973866.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Rodríguez-Franco P, Brugués A, Marín-Llauradó A, Conte V, Solanas G, Batlle E, Fredberg JJ, Roca-Cusachs P, Sunyer R, Trepat X. Long-lived force patterns and deformation waves at repulsive epithelial boundaries. Nat Mater. 2017 10; 16(10):1029-1037. PMID: 28892054.
    Citations: 2     Fields:    
  21. Jang H, Notbohm J, Gweon B, Cho Y, Park CY, Kee SH, Fredberg JJ, Shin JH, Park Y. Homogenizing cellular tension by hepatocyte growth factor in expanding epithelial monolayer. Sci Rep. 2017 04 04; 8:45844. PMID: 28374776.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Rosner SR, Pascoe CD, Blankman E, Jensen CC, Krishnan R, James AL, Elliot JG, Green FH, Liu JC, Seow CY, Park JA, Beckerle MC, Paré PD, Fredberg JJ, Smith MA. The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. PLoS One. 2017; 12(3):e0171728. PMID: 28278518.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS. Corrigendum: Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice. Front Physiol. 2017; 8:117. PMID: 28261114.
  24. Bhatawadekar SA, Inman MD, Fredberg JJ, Tarlo SM, Lyons OD, Keller G, Yadollahi A. Contribution of rostral fluid shift to intrathoracic airway narrowing in asthma. J Appl Physiol (1985). 2017 Apr 01; 122(4):809-816. PMID: 28082337.
    Citations: 2     Fields:    Translation:Humans
  25. Alencar AM, Ferraz MS, Park CY, Millet E, Trepat X, Fredberg JJ, Butler JP. Non-equilibrium cytoquake dynamics in cytoskeletal remodeling and stabilization. Soft Matter. 2016 Oct 19; 12(41):8506-8511. PMID: 27722665.
    Citations:    Fields:    Translation:HumansCells
  26. Park JA, Atia L, Mitchel JA, Fredberg JJ, Butler JP. Collective migration and cell jamming in asthma, cancer and development. J Cell Sci. 2016 09 15; 129(18):3375-83. PMID: 27550520.
    Citations: 5     Fields:    Translation:HumansAnimals
  27. Hiorns JE, Bidan CM, Jensen OE, Gosens R, Kistemaker LE, Fredberg JJ, Butler JP, Krishnan R, Brook BS. Airway and Parenchymal Strains during Bronchoconstriction in the Precision Cut Lung Slice. Front Physiol. 2016; 7:309. PMID: 27559314.
    Citations: 3     
  28. Notbohm J, Banerjee S, Utuje KJC, Gweon B, Jang H, Park Y, Shin J, Butler JP, Fredberg JJ, Marchetti MC. Cellular Contraction and Polarization Drive Collective Cellular Motion. Biophys J. 2016 Jun 21; 110(12):2729-2738. PMID: 27332131.
    Citations: 9     Fields:    Translation:AnimalsCells
  29. Faiz A, Donovan C, Nieuwenhuis MA, van den Berge M, Postma DS, Yao S, Park CY, Hirsch R, Fredberg JJ, Tjin G, Halayko AJ, Rempel KL, Ward JP, Lee T, Bossé Y, Nickle DC, Obeidat M, Vonk JM, Black JL, Oliver BG, Krishnan R, McParland B, Bourke JE, Burgess JK. Latrophilin receptors: novel bronchodilator targets in asthma. Thorax. 2017 01; 72(1):74-82. PMID: 27325752.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  30. Gazzola M, Henry C, Couture C, Marsolais D, King GG, Fredberg JJ, Bossé Y. Smooth muscle in human bronchi is disposed to resist airway distension. Respir Physiol Neurobiol. 2016 07 15; 229:51-8. PMID: 27095271.
    Citations: 1     Fields:    Translation:Humans
  31. Park JA, Mitchel JA, Qazvini NT, Kim JH, Park CY, Butler JP, Israel E, Randell SH, Shore SA, Drazen JM, Fredberg JJ. Compressive Stress Causes an Unjamming Transition and an Epithelial-Mesenchymal Transition in the Airway Epithelium in Asthma. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S102. PMID: 27027941.
    Citations:    Fields:    
  32. Park JA, Fredberg JJ. Cell Jamming in the Airway Epithelium. Ann Am Thorac Soc. 2016 Mar; 13 Suppl 1:S64-7. PMID: 27027955.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  33. Wang K, Cai LH, Lan B, Fredberg JJ. Hidden in the mist no more: physical force in cell biology. Nat Methods. 2016 Feb; 13(2):124-5. PMID: 26820546.
    Citations: 3     Fields:    Translation:Humans
  34. Pegoraro AF, Fredberg JJ, Park JA. Problems in biology with many scales of length: Cell-cell adhesion and cell jamming in collective cellular migration. Exp Cell Res. 2016 04 10; 343(1):54-59. PMID: 26546401.
    Citations: 2     Fields:    Translation:HumansAnimals
  35. Fredberg J, Sedwick C. Jeffrey Fredberg: Flow under pressure. J Cell Biol. 2015 Sep 14; 210(6):868-9. PMID: 26370495.
    Citations:    Fields:    Translation:HumansAnimals
  36. Tambe DT, Fredberg JJ. And I hope you like jamming too. New J Phys. 2015 Sep; 17(9). PMID: 27594802.
  37. Park JA, Kim JH, Bi D, Mitchel JA, Qazvini NT, Tantisira K, Park CY, McGill M, Kim SH, Gweon B, Notbohm J, Steward R, Burger S, Randell SH, Kho AT, Tambe DT, Hardin C, Shore SA, Israel E, Weitz DA, Tschumperlin DJ, Henske EP, Weiss ST, Manning ML, Butler JP, Drazen JM, Fredberg JJ. Unjamming and cell shape in the asthmatic airway epithelium. Nat Mater. 2015 Oct; 14(10):1040-8. PMID: 26237129.
    Citations: 24     Fields:    Translation:HumansCells
  38. Park JA, Fredberg JJ, Drazen JM. Putting the Squeeze on Airway Epithelia. Physiology (Bethesda). 2015 Jul; 30(4):293-303. PMID: 26136543.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  39. Park CY, Zhou EH, Tambe D, Chen B, Lavoie T, Dowell M, Simeonov A, Maloney DJ, Marinkovic A, Tschumperlin DJ, Burger S, Frykenberg M, Butler JP, Stamer WD, Johnson M, Solway J, Fredberg JJ, Krishnan R. High-throughput screening for modulators of cellular contractile force. Integr Biol (Camb). 2015 Oct; 7(10):1318-24. PMID: 25953078.
    Citations: 9     Fields:    Translation:HumansCells
  40. Steward R, Tambe D, Hardin CC, Krishnan R, Fredberg JJ. Fluid shear, intercellular stress, and endothelial cell alignment. Am J Physiol Cell Physiol. 2015 Apr 15; 308(8):C657-64. PMID: 25652451.
    Citations: 12     Fields:    Translation:HumansCells
  41. Chen C, Xie J, Rajappa R, Deng L, Fredberg J, Yang L. Interleukin-1ß and tumor necrosis factor-a increase stiffness and impair contractile function of articular chondrocytes. Acta Biochim Biophys Sin (Shanghai). 2015 Feb; 47(2):121-9. PMID: 25520178.
    Citations: 5     Fields:    Translation:AnimalsCells
  42. Zhou EH, Watson C, Pizzo R, Cohen J, Dang Q, Ferreira de Barros PM, Park CY, Chen C, Brain JD, Butler JP, Ruberti JW, Fredberg JJ, Demokritou P. Assessing the impact of engineered nanoparticles on wound healing using a novel in vitro bioassay. Nanomedicine (Lond). 2014 Dec; 9(18):2803-15. PMID: 24823434.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  43. Stamer WD, Braakman ST, Zhou EH, Ethier CR, Fredberg JJ, Overby DR, Johnson M. Biomechanics of Schlemm's canal endothelium and intraocular pressure reduction. Prog Retin Eye Res. 2015 Jan; 44:86-98. PMID: 25223880.
    Citations: 23     Fields:    Translation:HumansCells
  44. Mathai JC, Zhou EH, Yu W, Kim JH, Zhou G, Liao Y, Sun TT, Fredberg JJ, Zeidel ML. Hypercompliant apical membranes of bladder umbrella cells. Biophys J. 2014 Sep 16; 107(6):1273-9. PMID: 25229135.
    Citations: 3     Fields:    Translation:AnimalsCells
  45. Overby DR, Zhou EH, Vargas-Pinto R, Pedrigi RM, Fuchshofer R, Braakman ST, Gupta R, Perkumas KM, Sherwood JM, Vahabikashi A, Dang Q, Kim JH, Ethier CR, Stamer WD, Fredberg JJ, Johnson M. Altered mechanobiology of Schlemm's canal endothelial cells in glaucoma. Proc Natl Acad Sci U S A. 2014 Sep 23; 111(38):13876-81. PMID: 25201985.
    Citations: 31     Fields:    Translation:HumansCells
  46. Tambe DT, Butler JP, Fredberg JJ. Comment on "Intracellular stresses in patterned cell assemblies" by M. Moussus et al., Soft Matter, 2014, 10, 2414. Soft Matter. 2014 Oct 21; 10(39):7681-2. PMID: 25186230.
    Citations:    Fields:    Translation:HumansCells
  47. Fredberg JJ. Power steering, power brakes, and jamming: evolution of collective cell-cell interactions. Physiology (Bethesda). 2014 Jul; 29(4):218-9. PMID: 24985324.
    Citations: 3     Fields:    Translation:AnimalsCells
  48. Rosner SR, Ram-Mohan S, Paez-Cortez JR, Lavoie TL, Dowell ML, Yuan L, Ai X, Fine A, Aird WC, Solway J, Fredberg JJ, Krishnan R. Airway contractility in the precision-cut lung slice after cryopreservation. Am J Respir Cell Mol Biol. 2014 May; 50(5):876-81. PMID: 24313705.
    Citations: 9     Fields:    Translation:AnimalsCells
  49. Sadati M, Nourhani A, Fredberg JJ, Taheri Qazvini N. Glass-like dynamics in the cell and in cellular collectives. Wiley Interdiscip Rev Syst Biol Med. 2014 Mar-Apr; 6(2):137-49. PMID: 24431332.
    Citations: 3     Fields:    Translation:HumansCells
  50. Coughlin MF, Fredberg JJ. Changes in cytoskeletal dynamics and nonlinear rheology with metastatic ability in cancer cell lines. Phys Biol. 2013 Dec; 10(6):065001. PMID: 24304722.
    Citations: 4     Fields:    Translation:HumansCells
  51. Sieck GC, Hunter P, Fredberg J, Notbohm J. Physiology's impact: Applying mathematics and advanced technologies. Physiology (Bethesda). 2013 Nov; 28(6):363-5. PMID: 24186929.
    Citations:    Fields:    Translation:HumansAnimalsCells
  52. Guo M, Ehrlicher AJ, Mahammad S, Fabich H, Jensen MH, Moore JR, Fredberg JJ, Goldman RD, Weitz DA. The role of vimentin intermediate filaments in cortical and cytoplasmic mechanics. Biophys J. 2013 Oct 01; 105(7):1562-8. PMID: 24094397.
    Citations: 55     Fields:    Translation:AnimalsCells
  53. Kim JH, Serra-Picamal X, Tambe DT, Zhou EH, Park CY, Sadati M, Park JA, Krishnan R, Gweon B, Millet E, Butler JP, Trepat X, Fredberg JJ. Propulsion and navigation within the advancing monolayer sheet. Nat Mater. 2013 Sep; 12(9):856-63. PMID: 23793160.
    Citations: 38     Fields:    Translation:AnimalsCells
  54. Sadati M, Taheri Qazvini N, Krishnan R, Park CY, Fredberg JJ. Collective migration and cell jamming. Differentiation. 2013 Oct; 86(3):121-5. PMID: 23791490.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  55. Hardin C, Rajendran K, Manomohan G, Tambe DT, Butler JP, Fredberg JJ, Martinelli R, Carman CV, Krishnan R. Glassy dynamics, cell mechanics, and endothelial permeability. J Phys Chem B. 2013 Oct 24; 117(42):12850-6. PMID: 23638866.
    Citations: 1     Fields:    Translation:HumansCells
  56. Steward RL, Rosner SR, Zhou EH, Fredberg JJ. Illuminating human health through cell mechanics. Swiss Med Wkly. 2013; 143:w13766. PMID: 23519500.
    Citations:    Fields:    Translation:Humans
  57. Zhou EH, Martinez FD, Fredberg JJ. Cell rheology: mush rather than machine. Nat Mater. 2013 Mar; 12(3):184-5. PMID: 23422717.
    Citations: 3     Fields:    Translation:Cells
  58. Tambe DT, Croutelle U, Trepat X, Park CY, Kim JH, Millet E, Butler JP, Fredberg JJ. Monolayer stress microscopy: limitations, artifacts, and accuracy of recovered intercellular stresses. PLoS One. 2013; 8(2):e55172. PMID: 23468843.
    Citations: 32     Fields:    
  59. Hardin C, Fredberg JJ, Krishnan R. Real estate of monolayer permeability: location location location. Lab Invest. 2013 Feb; 93(2):148-50. PMID: 23361599.
    Citations: 1     Fields:    Translation:HumansCells
  60. Patel NR, Bole M, Chen C, Hardin CC, Kho AT, Mih J, Deng L, Butler J, Tschumperlin D, Fredberg JJ, Krishnan R, Koziel H. Cell elasticity determines macrophage function. PLoS One. 2012; 7(9):e41024. PMID: 23028423.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  61. Coughlin MF, Bielenberg DR, Lenormand G, Marinkovic M, Waghorne CG, Zetter BR, Fredberg JJ. Cytoskeletal stiffness, friction, and fluidity of cancer cell lines with different metastatic potential. Clin Exp Metastasis. 2013 Mar; 30(3):237-50. PMID: 22961212.
    Citations: 19     Fields:    Translation:HumansCells
  62. Krishnan R, Canovic EP, Iordan AL, Rajendran K, Manomohan G, Pirentis AP, Smith ML, Butler JP, Fredberg JJ, Stamenovic D. Fluidization, resolidification, and reorientation of the endothelial cell in response to slow tidal stretches. Am J Physiol Cell Physiol. 2012 Aug 15; 303(4):C368-75. PMID: 22700796.
    Citations: 13     Fields:    Translation:HumansCells
  63. Lavoie TL, Krishnan R, Siegel HR, Maston ED, Fredberg JJ, Solway J, Dowell ML. Dilatation of the constricted human airway by tidal expansion of lung parenchyma. Am J Respir Crit Care Med. 2012 Aug 01; 186(3):225-32. PMID: 22679010.
    Citations: 26     Fields:    Translation:Humans
  64. Mizrahi N, Zhou EH, Lenormand G, Krishnan R, Weihs D, Butler JP, Weitz DA, Fredberg JJ, Kimmel E. Low intensity ultrasound perturbs cytoskeleton dynamics. Soft Matter. 2012 Feb 28; 8(8):2438-2443. PMID: 23646063.
    Citations: 6     Fields:    
  65. Krishnan R, Fredberg JJ. In bronchospasm, fluctuations come to life. Am J Respir Crit Care Med. 2011 Dec 15; 184(12):1321-2. PMID: 22174106.
    Citations:    Fields:    Translation:Humans
  66. Zhou EH, Krishnan R, Stamer WD, Perkumas KM, Rajendran K, Nabhan JF, Lu Q, Fredberg JJ, Johnson M. Mechanical responsiveness of the endothelial cell of Schlemm's canal: scope, variability and its potential role in controlling aqueous humour outflow. J R Soc Interface. 2012 Jun 07; 9(71):1144-55. PMID: 22171066.
    Citations: 34     Fields:    Translation:HumansCells
  67. Trepat X, Fredberg JJ. Plithotaxis and emergent dynamics in collective cellular migration. Trends Cell Biol. 2011 Nov; 21(11):638-46. PMID: 21784638.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  68. Lenormand G, Millet E, Park CY, Hardin CC, Butler JP, Moldovan NI, Fredberg JJ. Dynamics of the cytoskeleton: how much does water matter? Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Jun; 83(6 Pt 1):061918. PMID: 21797414.
    Citations: 1     Fields:    Translation:HumansCells
  69. Tambe DT, Hardin CC, Angelini TE, Rajendran K, Park CY, Serra-Picamal X, Zhou EH, Zaman MH, Butler JP, Weitz DA, Fredberg JJ, Trepat X. Collective cell guidance by cooperative intercellular forces. Nat Mater. 2011 Jun; 10(6):469-75. PMID: 21602808.
    Citations: 187     Fields:    Translation:AnimalsCells
  70. Angelini TE, Hannezo E, Trepat X, Marquez M, Fredberg JJ, Weitz DA. Glass-like dynamics of collective cell migration. Proc Natl Acad Sci U S A. 2011 Mar 22; 108(12):4714-9. PMID: 21321233.
    Citations: 75     Fields:    Translation:AnimalsCells
  71. An SS, Askovich PS, Zarembinski TI, Ahn K, Peltier JM, von Rechenberg M, Sahasrabudhe S, Fredberg JJ. A novel small molecule target in human airway smooth muscle for potential treatment of obstructive lung diseases: a staged high-throughput biophysical screening. Respir Res. 2011 Jan 13; 12:8. PMID: 21232113.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  72. Seow CY, Fredberg JJ. Emergence of airway smooth muscle functions related to structural malleability. J Appl Physiol (1985). 2011 Apr; 110(4):1130-5. PMID: 21127211.
    Citations: 6     Fields:    Translation:HumansAnimals
  73. Trepat X, Fabry B, Fredberg JJ. Pulling it together in three dimensions. Nat Methods. 2010 Dec; 7(12):963-5. PMID: 21116244.
    Citations: 2     Fields:    Translation:Animals
  74. Lin YC, Tambe DT, Park CY, Wasserman MR, Trepat X, Krishnan R, Lenormand G, Fredberg JJ, Butler JP. Mechanosensing of substrate thickness. Phys Rev E Stat Nonlin Soft Matter Phys. 2010 Oct; 82(4 Pt 1):041918. PMID: 21230324.
    Citations: 17     Fields:    Translation:HumansCells
  75. Oliver M, Kováts T, Mijailovich SM, Butler JP, Fredberg JJ, Lenormand G. Remodeling of integrated contractile tissues and its dependence on strain-rate amplitude. Phys Rev Lett. 2010 Oct 08; 105(15):158102. PMID: 21230941.
    Citations: 7     Fields:    Translation:Animals
  76. Krishnan R, Klumpers DD, Park CY, Rajendran K, Trepat X, van Bezu J, van Hinsbergh VW, Carman CV, Brain JD, Fredberg JJ, Butler JP, van Nieuw Amerongen GP. Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces. Am J Physiol Cell Physiol. 2011 Jan; 300(1):C146-54. PMID: 20861463.
    Citations: 61     Fields:    Translation:HumansCells
  77. Chen C, Krishnan R, Zhou E, Ramachandran A, Tambe D, Rajendran K, Adam RM, Deng L, Fredberg JJ. Fluidization and resolidification of the human bladder smooth muscle cell in response to transient stretch. PLoS One. 2010 Aug 06; 5(8):e12035. PMID: 20700509.
    Citations: 30     Fields:    Translation:HumansCells
  78. DiPaolo BC, Lenormand G, Fredberg JJ, Margulies SS. Stretch magnitude and frequency-dependent actin cytoskeleton remodeling in alveolar epithelia. Am J Physiol Cell Physiol. 2010 Aug; 299(2):C345-53. PMID: 20519449.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  79. Angelini TE, Hannezo E, Trepat X, Fredberg JJ, Weitz DA. Cell migration driven by cooperative substrate deformation patterns. Phys Rev Lett. 2010 Apr 23; 104(16):168104. PMID: 20482085.
    Citations: 56     Fields:    Translation:AnimalsCells
  80. Berntsen P, Park CY, Rothen-Rutishauser B, Tsuda A, Sager TM, Molina RM, Donaghey TC, Alencar AM, Kasahara DI, Ericsson T, Millet EJ, Swenson J, Tschumperlin DJ, Butler JP, Brain JD, Fredberg JJ, Gehr P, Zhou EH. Biomechanical effects of environmental and engineered particles on human airway smooth muscle cells. J R Soc Interface. 2010 Jun 06; 7 Suppl 3:S331-40. PMID: 20356875.
    Citations: 12     Fields:    Translation:HumansCells
  81. Park CY, Tambe D, Alencar AM, Trepat X, Zhou EH, Millet E, Butler JP, Fredberg JJ. Mapping the cytoskeletal prestress. Am J Physiol Cell Physiol. 2010 May; 298(5):C1245-52. PMID: 20164383.
    Citations: 23     Fields:    Translation:HumansCells
  82. Dowell ML, Lavoie TL, Lakser OJ, Dulin NO, Fredberg JJ, Gerthoffer WT, Seow CY, Mitchell RW, Solway J. MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle. Eur Respir J. 2010 Sep; 36(3):630-7. PMID: 20110395.
    Citations: 5     Fields:    Translation:AnimalsCells
  83. Bellin RM, Kubicek JD, Frigault MJ, Kamien AJ, Steward RL, Barnes HM, Digiacomo MB, Duncan LJ, Edgerly CK, Morse EM, Park CY, Fredberg JJ, Cheng CM, LeDuc PR. Defining the role of syndecan-4 in mechanotransduction using surface-modification approaches. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22102-7. PMID: 20080785.
    Citations: 30     Fields:    Translation:AnimalsCells
  84. Sunyer R, Trepat X, Fredberg JJ, Farré R, Navajas D. The temperature dependence of cell mechanics measured by atomic force microscopy. Phys Biol. 2009 Jul 01; 6(2):025009. PMID: 19571363.
    Citations: 13     Fields:    Translation:HumansCells
  85. Zhou EH, Trepat X, Park CY, Lenormand G, Oliver MN, Mijailovich SM, Hardin C, Weitz DA, Butler JP, Fredberg JJ. Universal behavior of the osmotically compressed cell and its analogy to the colloidal glass transition. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10632-7. PMID: 19520830.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  86. Krishnan R, Park CY, Lin YC, Mead J, Jaspers RT, Trepat X, Lenormand G, Tambe D, Smolensky AV, Knoll AH, Butler JP, Fredberg JJ. Reinforcement versus fluidization in cytoskeletal mechanoresponsiveness. PLoS One. 2009; 4(5):e5486. PMID: 19424501.
    Citations: 81     Fields:    Translation:HumansCells
  87. Lavoie TL, Dowell ML, Lakser OJ, Gerthoffer WT, Fredberg JJ, Seow CY, Mitchell RW, Solway J. Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma? Proc Am Thorac Soc. 2009 May 01; 6(3):295-300. PMID: 19387033.
    Citations: 12     Fields:    Translation:HumansCells
  88. An SS, Kim J, Ahn K, Trepat X, Drake KJ, Kumar S, Ling G, Purington C, Rangasamy T, Kensler TW, Mitzner W, Fredberg JJ, Biswal S. Cell stiffness, contractile stress and the role of extracellular matrix. Biochem Biophys Res Commun. 2009 May 15; 382(4):697-703. PMID: 19327344.
    Citations: 16     Fields:    Translation:AnimalsCells
  89. Discher D, Dong C, Fredberg JJ, Guilak F, Ingber D, Janmey P, Kamm RD, Schmid-Schönbein GW, Weinbaum S. Biomechanics: cell research and applications for the next decade. Ann Biomed Eng. 2009 May; 37(5):847-59. PMID: 19259817.
    Citations: 50     Fields:    Translation:HumansCells
  90. Mott A, Lenormand G, Costales J, Fredberg JJ, Burleigh BA. Modulation of host cell mechanics by Trypanosoma cruzi. J Cell Physiol. 2009 Feb; 218(2):315-22. PMID: 18853412.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  91. Vyshedskiy A, Alhashem RM, Paciej R, Ebril M, Rudman I, Fredberg JJ, Murphy R. Mechanism of inspiratory and expiratory crackles. Chest. 2009 Jan; 135(1):156-164. PMID: 18689587.
    Citations: 6     Fields:    Translation:Humans
  92. Marinkovic M, Diez-Silva M, Pantic I, Fredberg JJ, Suresh S, Butler JP. Febrile temperature leads to significant stiffening of Plasmodium falciparum parasitized erythrocytes. Am J Physiol Cell Physiol. 2009 Jan; 296(1):C59-64. PMID: 18596215.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  93. Fredberg JJ. Being uncomfortable. J Appl Physiol (1985). 2008 06; 104(6):1848-9; author reply 1851. PMID: 18584786.
    Citations:    Fields:    Translation:HumansAnimals
  94. Krishnan R, Trepat X, Nguyen TT, Lenormand G, Oliver M, Fredberg JJ. Airway smooth muscle and bronchospasm: fluctuating, fluidizing, freezing. Respir Physiol Neurobiol. 2008 Nov 30; 163(1-3):17-24. PMID: 18514592.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  95. Nguyen TT, Fredberg JJ. Strange dynamics of a dynamic cytoskeleton. Proc Am Thorac Soc. 2008 Jan 01; 5(1):58-61. PMID: 18094085.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  96. Fredberg JJ. "Lung impedance measurements are/are not more useful than simpler measurements of lung function in animal models of pulmonary disease". J Appl Physiol (1985). 2007 11; 103(5):1905; author reply 1909-10. PMID: 18098386.
    Citations:    Fields:    Translation:Animals
  97. Lenormand G, Bursac P, Butler JP, Fredberg JJ. Out-of-equilibrium dynamics in the cytoskeleton of the living cell. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Oct; 76(4 Pt 1):041901. PMID: 17995020.
    Citations: 9     Fields:    Translation:HumansCells
  98. Ratnovsky A, Mellema M, An SS, Fredberg JJ, Shore SA. Airway smooth muscle proliferation and mechanics: effects of AMP kinase agonists. Mol Cell Biomech. 2007 Sep; 4(3):143-57. PMID: 18320901.
    Citations: 3     Fields:    Translation:AnimalsCells
  99. Lenormand G, Chopin J, Bursac P, Fredberg JJ, Butler JP. Directional memory and caged dynamics in cytoskeletal remodelling. Biochem Biophys Res Commun. 2007 Sep 07; 360(4):797-801. PMID: 17631276.
    Citations: 9     Fields:    Translation:HumansCells
  100. An SS, Fredberg JJ. Biophysical basis for airway hyperresponsiveness. Can J Physiol Pharmacol. 2007 Jul; 85(7):700-14. PMID: 17823634.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  101. Trepat X, Deng L, An SS, Navajas D, Tschumperlin DJ, Gerthoffer WT, Butler JP, Fredberg JJ. Universal physical responses to stretch in the living cell. Nature. 2007 May 31; 447(7144):592-5. PMID: 17538621.
    Citations: 190     Fields:    Translation:HumansAnimalsCells
  102. An SS, Bai TR, Bates JH, Black JL, Brown RH, Brusasco V, Chitano P, Deng L, Dowell M, Eidelman DH, Fabry B, Fairbank NJ, Ford LE, Fredberg JJ, Gerthoffer WT, Gilbert SH, Gosens R, Gunst SJ, Halayko AJ, Ingram RH, Irvin CG, James AL, Janssen LJ, King GG, Knight DA, Lauzon AM, Lakser OJ, Ludwig MS, Lutchen KR, Maksym GN, Martin JG, Mauad T, McParland BE, Mijailovich SM, Mitchell HW, Mitchell RW, Mitzner W, Murphy TM, Paré PD, Pellegrino R, Sanderson MJ, Schellenberg RR, Seow CY, Silveira PS, Smith PG, Solway J, Stephens NL, Sterk PJ, Stewart AG, Tang DD, Tepper RS, Tran T, Wang L. Airway smooth muscle dynamics: a common pathway of airway obstruction in asthma. Eur Respir J. 2007 May; 29(5):834-60. PMID: 17470619.
    Citations: 95     Fields:    Translation:Humans
  103. Oliver MN, Fabry B, Marinkovic A, Mijailovich SM, Butler JP, Fredberg JJ. Airway hyperresponsiveness, remodeling, and smooth muscle mass: right answer, wrong reason? Am J Respir Cell Mol Biol. 2007 Sep; 37(3):264-72. PMID: 17463392.
    Citations: 40     Fields:    Translation:HumansAnimals
  104. Puig-de-Morales-Marinkovic M, Turner KT, Butler JP, Fredberg JJ, Suresh S. Viscoelasticity of the human red blood cell. Am J Physiol Cell Physiol. 2007 Aug; 293(2):C597-605. PMID: 17428838.
    Citations: 30     Fields:    Translation:HumansCells
  105. Fredberg JJ. Counterpoint: airway smooth muscle is not useful. J Appl Physiol (1985). 2007 Apr; 102(4):1709-10; discussion 1710-1. PMID: 17409290.
    Citations: 3     Fields:    Translation:HumansAnimals
  106. Bursac P, Fabry B, Trepat X, Lenormand G, Butler JP, Wang N, Fredberg JJ, An SS. Cytoskeleton dynamics: fluctuations within the network. Biochem Biophys Res Commun. 2007 Apr 06; 355(2):324-30. PMID: 17303084.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  107. Yim S, Fredberg JJ, Malhotra A. Continuous positive airway pressure for asthma: not a big stretch? Eur Respir J. 2007 Feb; 29(2):226-8. PMID: 17264319.
    Citations: 5     Fields:    Translation:Humans
  108. Fabry B, Fredberg JJ. Mechanotransduction, asthma, and airway smooth muscle. Drug Discov Today Dis Models. 2007; 4(3):131-137. PMID: 18836522.
    Citations: 6     
  109. Deng L, Trepat X, Butler JP, Millet E, Morgan KG, Weitz DA, Fredberg JJ. Fast and slow dynamics of the cytoskeleton. Nat Mater. 2006 Aug; 5(8):636-40. PMID: 16845421.
    Citations: 59     Fields:    Translation:AnimalsCells
  110. Chen B, Liu G, Shardonofsky F, Dowell M, Lakser O, Mitchell RW, Fredberg JJ, Pinto LH, Solway J. Tidal breathing pattern differentially antagonizes bronchoconstriction in C57BL/6J vs. A/J mice. J Appl Physiol (1985). 2006 Jul; 101(1):249-55. PMID: 16484363.
    Citations: 8     Fields:    Translation:AnimalsCells
  111. An SS, Fabry B, Trepat X, Wang N, Fredberg JJ. Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness? Am J Respir Cell Mol Biol. 2006 Jul; 35(1):55-64. PMID: 16484685.
    Citations: 37     Fields:    Translation:AnimalsCells
  112. Trepat X, Puig F, Gavara N, Fredberg JJ, Farre R, Navajas D. Effect of stretch on structural integrity and micromechanics of human alveolar epithelial cell monolayers exposed to thrombin. Am J Physiol Lung Cell Mol Physiol. 2006 Jun; 290(6):L1104-10. PMID: 16399786.
    Citations: 11     Fields:    Translation:HumansCells
  113. Lenormand G, Fredberg JJ. Deformability, dynamics, and remodeling of cytoskeleton of the adherent living cell. Biorheology. 2006; 43(1):1-30. PMID: 16627924.
    Citations: 13     Fields:    Translation:HumansCells
  114. Fredberg JJ, Kamm RD. Stress transmission in the lung: pathways from organ to molecule. Annu Rev Physiol. 2006; 68:507-41. PMID: 16460282.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  115. Coughlin MF, Puig-de-Morales M, Bursac P, Mellema M, Millet E, Fredberg JJ. Filamin-a and rheological properties of cultured melanoma cells. Biophys J. 2006 Mar 15; 90(6):2199-205. PMID: 16387775.
    Citations: 14     Fields:    Translation:HumansCells
  116. Silveira PS, Fredberg JJ. Smooth muscle length adaptation and actin filament length: a network model of the cytoskeletal dysregulation. Can J Physiol Pharmacol. 2005 Oct; 83(10):923-31. PMID: 16333364.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  117. Laudadio RE, Millet EJ, Fabry B, An SS, Butler JP, Fredberg JJ. Rat airway smooth muscle cell during actin modulation: rheology and glassy dynamics. Am J Physiol Cell Physiol. 2005 Dec; 289(6):C1388-95. PMID: 16120653.
    Citations: 26     Fields:    Translation:AnimalsCells