Harvard Catalyst Profiles

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Michael Barry Brenner, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01AI148102 (BRENNER, MICHAEL B.) Jun 15, 2021 - Mar 31, 2026
    NIH
    Differentiation of immune cells and fibrobalsts in inflamed tissue in RA and SLE
    Role: Principal Investigator
  2. R01AR073833 (BRENNER, MICHAEL B.) Aug 1, 2019 - Jul 31, 2024
    NIH
    Deciphering Pathways Driving Inflammatory Fibroblast Effector Functions in RA
    Role: Principal Investigator
  3. R21AI144139 (BRENNER, MICHAEL B.) Feb 20, 2019 - Jan 31, 2021
    NIH
    iNKT cells hyperactivate DCs
    Role: Principal Investigator
  4. R01AR073290 (BRENNER, MICHAEL B.) Sep 13, 2018 - Jun 30, 2023
    NIH
    Newly Identified T Peripheral Helper (Tph) Cells in Rheumatoid Arthritis
    Role: Principal Investigator
  5. R01AR063709 (BRENNER, MICHAEL B.) Feb 1, 2015 - Aug 31, 2026
    NIH
    Cadherin 11 Regulates Synovial Inflammation in Arthritis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Simmons DP, Nguyen HN, Gomez-Rivas E, Jeong Y, Jonsson AH, Chen AF, Lange JK, Dyer GS, Blazar P, Earp BE, Coblyn JS, Massarotti EM, Sparks JA, Todd DJ, Rao DA, Kim EY, Brenner MB. SLAMF7 engagement superactivates macrophages in acute and chronic inflammation. Sci Immunol. 2022 02 11; 7(68):eabf2846. PMID: 35148199.
    Citations:    Fields:    Translation:HumansCells
  2. Wei K, Nguyen HN, Brenner MB. Fibroblast pathology in inflammatory diseases. J Clin Invest. 2021 10 15; 131(20). PMID: 34651581.
    Citations: 3     Fields:    Translation:HumansCells
  3. LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB. Distinct iNKT Cell Populations Use IFN? or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. Cell Metab. 2020 08 04; 32(2):243-258.e6. PMID: 32516575.
    Citations: 16     Fields:    Translation:AnimalsCells
  4. Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB. Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-? in NK cells. J Clin Invest. 2020 06 01; 130(6):3238-3252. PMID: 32154791.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  5. Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB. Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature. 2020 06; 582(7811):259-264. PMID: 32499639.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  6. Donado CA, Cao AB, Simmons DP, Croker BA, Brennan PJ, Brenner MB. A Two-Cell Model for IL-1ß Release Mediated by Death-Receptor Signaling. Cell Rep. 2020 04 07; 31(1):107466. PMID: 32268091.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  7. Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL. Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells. Proc Natl Acad Sci U S A. 2020 04 21; 117(16):8900-8911. PMID: 32253314.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  8. Slowikowski K, Nguyen HN, Noss EH, Simmons DP, Mizoguchi F, Watts GFM, Gurish MF, Brenner MB, Raychaudhuri S. CUX1 and I?B? (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5532-5541. PMID: 32079724.
    Citations: 15     Fields:    Translation:HumansCells
  9. Gutierrez-Arcelus M, Baglaenko Y, Arora J, Hannes S, Luo Y, Amariuta T, Teslovich N, Rao DA, Ermann J, Jonsson AH, Navarrete C, Rich SS, Taylor KD, Rotter JI, Gregersen PK, Esko T, Brenner MB, Raychaudhuri S. Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci. Nat Genet. 2020 03; 52(3):247-253. PMID: 32066938.
    Citations: 23     Fields:    Translation:HumansCells
  10. Bocharnikov AV, Keegan J, Wacleche VS, Cao Y, Fonseka CY, Wang G, Muise ES, Zhang KX, Arazi A, Keras G, Li ZJ, Qu Y, Gurish MF, Petri M, Buyon JP, Putterman C, Wofsy D, James JA, Guthridge JM, Diamond B, Anolik JH, Mackey MF, Alves SE, Nigrovic PA, Costenbader KH, Brenner MB, Lederer JA, Rao DA. PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21. JCI Insight. 2019 10 17; 4(20). PMID: 31536480.
    Citations: 39     Fields:    Translation:HumansCells
  11. Clancy-Thompson E, Chen GZ, LaMarche NM, Ali LR, Jeong HJ, Crowley SJ, Boelaars K, Brenner MB, Lynch L, Dougan SK. Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1. EMBO J. 2019 07 15; 38(14):e101260. PMID: 31304630.
    Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
  12. Croft AP, Campos J, Jansen K, Turner JD, Marshall J, Attar M, Savary L, Wehmeyer C, Naylor AJ, Kemble S, Begum J, Dürholz K, Perlman H, Barone F, McGettrick HM, Fearon DT, Wei K, Raychaudhuri S, Korsunsky I, Brenner MB, Coles M, Sansom SN, Filer A, Buckley CD. Distinct fibroblast subsets drive inflammation and damage in arthritis. Nature. 2019 06; 570(7760):246-251. PMID: 31142839.
    Citations: 176     Fields:    Translation:HumansAnimalsCells
  13. Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM, Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol. 2019 07; 20(7):928-942. PMID: 31061532.
    Citations: 218     Fields:    Translation:HumansCells
  14. Madarampalli B, Watts GFM, Panipinto PM, Nguygen HN, Brenner MB, Noss EH. Interactions between cadherin-11 and platelet-derived growth factor receptor-alpha signaling link cell adhesion and proliferation. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1516-1524. PMID: 30876808.
    Citations: 8     Fields:    Translation:HumansCells
  15. Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L. Author Correction: ?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nat Immunol. 2019 Mar; 20(3):373. PMID: 30728493.
    Citations:    Fields:    
  16. Gutierrez-Arcelus M, Teslovich N, Mola AR, Polidoro RB, Nathan A, Kim H, Hannes S, Slowikowski K, Watts GFM, Korsunsky I, Brenner MB, Raychaudhuri S, Brennan PJ. Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions. Nat Commun. 2019 02 08; 10(1):687. PMID: 30737409.
    Citations: 36     Fields:    Translation:HumansCells
  17. Gansner JM, Rahmani M, Jonsson AH, Fortin BM, Brimah I, Ellis M, Smeland-Wagman R, Li ZJ, Schenkel JM, Brenner MB, Yefidoff-Freedman R, Sloan SR, Berliner N, Issa NC, Baden LR, Longo DL, Wesemann DR, Neuberg D, Rao DA, Kaufman RM. Plateletpheresis-associated lymphopenia in frequent platelet donors. Blood. 2019 02 07; 133(6):605-614. PMID: 30429159.
    Citations: 2     Fields:    Translation:HumansCells
  18. Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L. Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nat Immunol. 2018 12; 19(12):1330-1340. PMID: 30420624.
    Citations: 151     Fields:    Translation:HumansAnimals