Harvard Catalyst Profiles

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Michael Barry Brenner, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR073833 (BRENNER, MICHAEL B.) Aug 1, 2019 - Jul 31, 2024
    NIH/NIAMS
    Deciphering Pathways Driving Inflammatory Fibroblast Effector Functions in RA
    Role: Principal Investigator
  2. R21AI144139 (BRENNER, MICHAEL B.) Feb 20, 2019 - Jan 31, 2021
    NIH/NIAID
    iNKT cells hyperactivate DCs
    Role: Principal Investigator
  3. R01AR073290 (BRENNER, MICHAEL B.) Sep 13, 2018 - Jun 30, 2023
    NIH/NIAMS
    Newly Identified T Peripheral Helper (Tph) Cells in Rheumatoid Arthritis
    Role: Principal Investigator
  4. R01AR063709 (BRENNER, MICHAEL B.) Feb 1, 2015 - Jan 31, 2020
    NIH/NIAMS
    Cadherin 11 Regulates Synovial Inflammation in Arthritis
    Role: Principal Investigator
  5. UH2AR067677 (RAYCHAUDHURI, SOUMYA) Sep 24, 2014 - May 31, 2020
    NIH/NIAMS
    RA-SLE Molecular Deconstruction Leadership Center
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB. Distinct iNKT Cell Populations Use IFN? or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. Cell Metab. 2020 Aug 04; 32(2):243-258.e6. PMID: 32516575.
    Citations: 1     Fields:    
  2. Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB. Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-? in NK cells. J Clin Invest. 2020 Jun 01; 130(6):3238-3252. PMID: 32154791.
    Citations:    Fields:    
  3. Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB. Notch signalling drives synovial fibroblast identity and arthritis pathology. Nature. 2020 06; 582(7811):259-264. PMID: 32499639.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Donado CA, Cao AB, Simmons DP, Croker BA, Brennan PJ, Brenner MB. A Two-Cell Model for IL-1ß Release Mediated by Death-Receptor Signaling. Cell Rep. 2020 04 07; 31(1):107466. PMID: 32268091.
    Citations:    Fields:    
  5. Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL. Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells. Proc Natl Acad Sci U S A. 2020 04 21; 117(16):8900-8911. PMID: 32253314.
    Citations:    Fields:    Translation:HumansAnimalsCells
  6. Slowikowski K, Nguyen HN, Noss EH, Simmons DP, Mizoguchi F, Watts GFM, Gurish MF, Brenner MB, Raychaudhuri S. CUX1 and I?B? (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5532-5541. PMID: 32079724.
    Citations:    Fields:    Translation:HumansCells
  7. Gutierrez-Arcelus M, Baglaenko Y, Arora J, Hannes S, Luo Y, Amariuta T, Teslovich N, Rao DA, Ermann J, Jonsson AH, Navarrete C, Rich SS, Taylor KD, Rotter JI, Gregersen PK, Esko T, Brenner MB, Raychaudhuri S. Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci. Nat Genet. 2020 03; 52(3):247-253. PMID: 32066938.
    Citations: 5     Fields:    Translation:HumansCells
  8. Bocharnikov AV, Keegan J, Wacleche VS, Cao Y, Fonseka CY, Wang G, Muise ES, Zhang KX, Arazi A, Keras G, Li ZJ, Qu Y, Gurish MF, Petri M, Buyon JP, Putterman C, Wofsy D, James JA, Guthridge JM, Diamond B, Anolik JH, Mackey MF, Alves SE, Nigrovic PA, Costenbader KH, Brenner MB, Lederer JA, Rao DA. PD-1hiCXCR5- T peripheral helper cells promote B cell responses in lupus via MAF and IL-21. JCI Insight. 2019 10 17; 4(20). PMID: 31536480.
    Citations: 5     Fields:    Translation:HumansCells
  9. Clancy-Thompson E, Chen GZ, LaMarche NM, Ali LR, Jeong HJ, Crowley SJ, Boelaars K, Brenner MB, Lynch L, Dougan SK. Transnuclear mice reveal Peyer's patch iNKT cells that regulate B-cell class switching to IgG1. EMBO J. 2019 07 15; 38(14):e101260. PMID: 31304630.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  10. Croft AP, Campos J, Jansen K, Turner JD, Marshall J, Attar M, Savary L, Wehmeyer C, Naylor AJ, Kemble S, Begum J, Dürholz K, Perlman H, Barone F, McGettrick HM, Fearon DT, Wei K, Raychaudhuri S, Korsunsky I, Brenner MB, Coles M, Sansom SN, Filer A, Buckley CD. Distinct fibroblast subsets drive inflammation and damage in arthritis. Nature. 2019 06; 570(7760):246-251. PMID: 31142839.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  11. Zhang F, Wei K, Slowikowski K, Fonseka CY, Rao DA, Kelly S, Goodman SM, Tabechian D, Hughes LB, Salomon-Escoto K, Watts GFM, Jonsson AH, Rangel-Moreno J, Meednu N, Rozo C, Apruzzese W, Eisenhaure TM, Lieb DJ, Boyle DL, Mandelin AM, Boyce BF, DiCarlo E, Gravallese EM, Gregersen PK, Moreland L, Firestein GS, Hacohen N, Nusbaum C, Lederer JA, Perlman H, Pitzalis C, Filer A, Holers VM, Bykerk VP, Donlin LT, Anolik JH, Brenner MB, Raychaudhuri S. Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry. Nat Immunol. 2019 07; 20(7):928-942. PMID: 31061532.
    Citations: 52     Fields:    Translation:HumansCells
  12. Madarampalli B, Watts GFM, Panipinto PM, Nguygen HN, Brenner MB, Noss EH. Interactions between cadherin-11 and platelet-derived growth factor receptor-alpha signaling link cell adhesion and proliferation. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1516-1524. PMID: 30876808.
    Citations: 3     Fields:    Translation:HumansCells
  13. Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L. Author Correction: ?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nat Immunol. 2019 Mar; 20(3):373. PMID: 30728493.
    Citations:    Fields:    
  14. Gutierrez-Arcelus M, Teslovich N, Mola AR, Polidoro RB, Nathan A, Kim H, Hannes S, Slowikowski K, Watts GFM, Korsunsky I, Brenner MB, Raychaudhuri S, Brennan PJ. Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions. Nat Commun. 2019 02 08; 10(1):687. PMID: 30737409.
    Citations: 15     Fields:    Translation:HumansCells
  15. Gansner JM, Rahmani M, Jonsson AH, Fortin BM, Brimah I, Ellis M, Smeland-Wagman R, Li ZJ, Schenkel JM, Brenner MB, Yefidoff-Freedman R, Sloan SR, Berliner N, Issa NC, Baden LR, Longo DL, Wesemann DR, Neuberg D, Rao DA, Kaufman RM. Plateletpheresis-associated lymphopenia in frequent platelet donors. Blood. 2019 02 07; 133(6):605-614. PMID: 30429159.
    Citations: 1     Fields:    Translation:HumansCells
  16. Michelet X, Dyck L, Hogan A, Loftus RM, Duquette D, Wei K, Beyaz S, Tavakkoli A, Foley C, Donnelly R, O'Farrelly C, Raverdeau M, Vernon A, Pettee W, O'Shea D, Nikolajczyk BS, Mills KHG, Brenner MB, Finlay D, Lynch L. Metabolic reprogramming of natural killer cells in obesity limits antitumor responses. Nat Immunol. 2018 12; 19(12):1330-1340. PMID: 30420624.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  17. Fonseka CY, Rao DA, Teslovich NC, Korsunsky I, Hannes SK, Slowikowski K, Gurish MF, Donlin LT, Lederer JA, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Todd DJ, Bykerk VP, Karlson EW, Ermann J, Lee YC, Brenner MB, Raychaudhuri S. Mixed-effects association of single cells identifies an expanded effector CD4+ T cell subset in rheumatoid arthritis. Sci Transl Med. 2018 10 17; 10(463). PMID: 30333237.
    Citations: 8     Fields:    Translation:HumansCells
  18. LaMarche NM, Kohlgruber AC, Brenner MB. Innate T Cells Govern Adipose Tissue Biology. J Immunol. 2018 10 01; 201(7):1827-1834. PMID: 30224362.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  19. Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra HJ, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA. High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction. Nat Genet. 2018 08; 50(8):1180-1188. PMID: 30013183.
    Citations: 4     Fields:    Translation:HumansCells
  20. Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L. ?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis. Nat Immunol. 2018 05; 19(5):464-474. PMID: 29670241.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  21. Michelet X, Tuli A, Gan H, Geadas C, Sharma M, Remold HG, Brenner MB. Lysosome-Mediated Plasma Membrane Repair Is Dependent on the Small GTPase Arl8b and Determines Cell Death Type in Mycobacterium tuberculosis Infection. J Immunol. 2018 05 01; 200(9):3160-3169. PMID: 29592961.
    Citations:    Fields:    Translation:HumansCells
  22. Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB. Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis. Nat Commun. 2018 02 23; 9(1):789. PMID: 29476097.
    Citations: 44     Fields:    Translation:HumansCells
  23. Chang SK, Kohlgruber AC, Mizoguchi F, Michelet X, Wolf BJ, Wei K, Lee PY, Lynch L, Duquette D, Ceperuelo-Mallafré V, Banks AS, Brenner MB. Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes. J Clin Invest. 2017 Sep 01; 127(9):3300-3312. PMID: 28758901.
    Citations: 9     Fields:    Translation:AnimalsCells
  24. Brennan PJ, Cheng TY, Pellicci DG, Watts GFM, Veerapen N, Young DC, Rossjohn J, Besra GS, Godfrey DI, Brenner MB, Moody DB. Structural determination of lipid antigens captured at the CD1d-T-cell receptor interface. Proc Natl Acad Sci U S A. 2017 08 01; 114(31):8348-8353. PMID: 28716901.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  25. Boulenouar S, Michelet X, Duquette D, Alvarez D, Hogan AE, Dold C, O'Connor D, Stutte S, Tavakkoli A, Winters D, Exley MA, O'Shea D, Brenner MB, von Andrian U, Lynch L. Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity. Immunity. 2017 02 21; 46(2):273-286. PMID: 28228283.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  26. Nguyen HN, Noss EH, Mizoguchi F, Huppertz C, Wei KS, Watts GFM, Brenner MB. Autocrine Loop Involving IL-6 Family Member LIF, LIF Receptor, and STAT4 Drives Sustained Fibroblast Production of Inflammatory Mediators. Immunity. 2017 02 21; 46(2):220-232. PMID: 28228280.
    Citations: 13     Fields:    Translation:HumansCells
  27. Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 2017 02 01; 542(7639):110-114. PMID: 28150777.
    Citations: 104     Fields:    Translation:HumansCells
  28. Fineran P, Lloyd-Evans E, Lack NA, Platt N, Davis LC, Morgan AJ, Höglinger D, Tatituri RVV, Clark S, Williams IM, Tynan P, Al Eisa N, Nazarova E, Williams A, Galione A, Ory DS, Besra GS, Russell DG, Brenner MB, Sim E, Platt FM. Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway. Wellcome Open Res. 2016 Nov 18; 1:18. PMID: 28008422.
    Citations: 7     
  29. Birtolo C, Pham H, Morvaridi S, Chheda C, Go VL, Ptasznik A, Edderkaoui M, Weisman MH, Noss E, Brenner MB, Larson B, Guindi M, Wang Q, Pandol SJ. Cadherin-11 Is a Cell Surface Marker Up-Regulated in Activated Pancreatic Stellate Cells and Is Involved in Pancreatic Cancer Cell Migration. Am J Pathol. 2017 Jan; 187(1):146-155. PMID: 27855278.
    Citations:    
  30. Kohlgruber AC, Donado CA, LaMarche NM, Brenner MB, Brennan PJ. Activation strategies for invariant natural killer T cells. Immunogenetics. 2016 08; 68(8):649-63. PMID: 27457886.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  31. Encarnação M, Espada L, Escrevente C, Mateus D, Ramalho J, Michelet X, Santarino I, Hsu VW, Brenner MB, Barral DC, Vieira OV. A Rab3a-dependent complex essential for lysosome positioning and plasma membrane repair. J Cell Biol. 2016 06 20; 213(6):631-40. PMID: 27325790.
    Citations: 17     Fields:    Translation:HumansCells
  32. Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L. Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181. J Immunol. 2016 05 01; 196(9):3514-6. PMID: 27183648.
    Citations: 1     Fields:    Translation:HumansCells
  33. Brenner MB, McLean J, Dialynas DP, Strominger JL, Smith JA, Owen FL, Seidman JG, Ip S, Rosen F, Krangel MS. Pillars Article: Identification of a Putative Second T-cell Receptor. Nature. 1986. 322: 145-149. J Immunol. 2016 05 01; 196(9):3509-13. PMID: 27183647.
    Citations:    Fields:    Translation:HumansCells
  34. Van Rhijn I, van Berlo T, Hilmenyuk T, Cheng TY, Wolf BJ, Tatituri RV, Uldrich AP, Napolitani G, Cerundolo V, Altman JD, Willemsen P, Huang S, Rossjohn J, Besra GS, Brenner MB, Godfrey DI, Moody DB. Human autoreactive T cells recognize CD1b and phospholipids. Proc Natl Acad Sci U S A. 2016 Jan 12; 113(2):380-5. PMID: 26621732.
    Citations: 31     Fields:    Translation:HumansCells
  35. Noss EH, Nguyen HN, Chang SK, Watts GF, Brenner MB. Genetic polymorphism directs IL-6 expression in fibroblasts but not selected other cell types. Proc Natl Acad Sci U S A. 2015 Dec 01; 112(48):14948-53. PMID: 26578807.
    Citations: 16     Fields:    Translation:HumansCells
  36. Wolf BJ, Tatituri RV, Almeida CF, Le Nours J, Bhowruth V, Johnson D, Uldrich AP, Hsu FF, Brigl M, Besra GS, Rossjohn J, Godfrey DI, Brenner MB. Identification of a Potent Microbial Lipid Antigen for Diverse NKT Cells. J Immunol. 2015 Sep 15; 195(6):2540-51. PMID: 26254340.
    Citations: 17     Fields:    Translation:AnimalsCells
  37. Ermann J, Rao DA, Teslovich NC, Brenner MB, Raychaudhuri S. Immune cell profiling to guide therapeutic decisions in rheumatic diseases. Nat Rev Rheumatol. 2015 Sep; 11(9):541-51. PMID: 26034835.
    Citations: 16     Fields:    Translation:HumansCells
  38. Noss EH, Watts GF, Zocco D, Keller TL, Whitman M, Blobel CP, Lee DM, Brenner MB. Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism. Arthritis Res Ther. 2015 May 15; 17:126. PMID: 25975695.
    Citations: 6     Fields:    Translation:HumansCells
  39. Kim EY, Lynch L, Brennan PJ, Cohen NR, Brenner MB. The transcriptional programs of iNKT cells. Semin Immunol. 2015 Feb; 27(1):26-32. PMID: 25841627.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  40. Tatituri RV, Wolf BJ, Brenner MB, Turk J, Hsu FF. Characterization of polar lipids of Listeria monocytogenes by HCD and low-energy CAD linear ion-trap mass spectrometry with electrospray ionization. Anal Bioanal Chem. 2015 Mar; 407(9):2519-28. PMID: 25656850.
    Citations: 9     Fields:    Translation:Cells
  41. Michelet X, Garg S, Wolf BJ, Tuli A, Ricciardi-Castagnoli P, Brenner MB. MHC class II presentation is controlled by the lysosomal small GTPase, Arl8b. J Immunol. 2015 Mar 01; 194(5):2079-88. PMID: 25637027.
    Citations: 7     Fields:    Translation:AnimalsCells
  42. Garg S, Brenner MB. RNAi screens of lysosomal trafficking. Methods Cell Biol. 2015; 126:119-38. PMID: 25665444.
    Citations:    Fields:    Translation:HumansAnimalsCells
  43. Lynch L, Michelet X, Zhang S, Brennan PJ, Moseman A, Lester C, Besra G, Vomhof-Dekrey EE, Tighe M, Koay HF, Godfrey DI, Leadbetter EA, Sant'Angelo DB, von Andrian U, Brenner MB. Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue. Nat Immunol. 2015 Jan; 16(1):85-95. PMID: 25436972.
    Citations: 126     Fields:    Translation:AnimalsCells
  44. Brennan PJ, Tatituri RV, Heiss C, Watts GF, Hsu FF, Veerapen N, Cox LR, Azadi P, Besra GS, Brenner MB. Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13433-8. PMID: 25197085.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  45. Porcelli S, Yockey CE, Brenner MB, Balk SP. Pillars article: analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- a/ß T cells demonstrates preferential use of several Vß genes and an invariant TCR a chain. J. Exp. Med. 1993. 178: 1-16. J Immunol. 2014 Aug 01; 193(3):977-92. PMID: 25049428.
    Citations:    Fields:    Translation:HumansAnimalsCells
  46. Hu X, Kim H, Raj T, Brennan PJ, Trynka G, Teslovich N, Slowikowski K, Chen WM, Onengut S, Baecher-Allan C, De Jager PL, Rich SS, Stranger BE, Brenner MB, Raychaudhuri S. Regulation of gene expression in autoimmune disease loci and the genetic basis of proliferation in CD4+ effector memory T cells. PLoS Genet. 2014 Jun; 10(6):e1004404. PMID: 24968232.
    Citations: 15     Fields:    Translation:HumansCells
  47. Bassiri H, Das R, Guan P, Barrett DM, Brennan PJ, Banerjee PP, Wiener SJ, Orange JS, Brenner MB, Grupp SA, Nichols KE. iNKT cell cytotoxic responses control T-lymphoma growth in vitro and in vivo . Cancer Immunol Res. 2014 Jan; 2(1):59-69. PMID: 24563871.
    Citations: 19     Fields:    Translation:AnimalsCells