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Thomas Seth Kupper, M.D.

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Institution
Department
Address
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Other Positions
Title
Institution
Department

Mentoring
completed student projects
Characterizing the Conformation of Beta1 Integrins on Resident Memory T Cells in the Skin
Summer, 06/11/13 - 08/22/13
Epidermal Antigens in Psoriasis
Full Time/Year Long, 09/04/01 - 08/01/02
T Cells and Defensins: An Interface Between Innate and Acquired Immunity PASTEUR
Summer, 06/26/00 - 08/18/00
The Regulation and Expression of T-Lymphocyte Skin-Homing Receptors, CLA and CCR4-Implications for CTCL
Full Time/Year Long, 11/15/99 - 12/15/00

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01AI127654 (KUPPER, THOMAS S.) Dec 14, 2016 - Nov 30, 2021
    NIH/NIAID
    Generation of Robust Resident Memory T cells in Barrier Tissues through Skin Vaccination
    Role: Co-Principal Investigator
  2. R01CA203721 (CLARK, RACHAEL ANN) Apr 23, 2016 - Mar 31, 2021
    NIH/NCI
    Transforming the diagnosis and care of patients with CTCL using TCR sequencing
    Role: Co-Principal Investigator
  3. R01AR065807 (KUPPER, THOMAS S.) Mar 28, 2014 - Aug 31, 2023
    NIH/NIAMS
    Skin Homing T Cells
    Role: Principal Investigator
  4. R01AI097128 (KUPPER, THOMAS S.) Sep 20, 2011 - Aug 31, 2016
    NIH/NIAID
    Vaccination to generate protective tissue resident T cells
    Role: Co-Principal Investigator
  5. P50CA093683 (KUPPER, THOMAS S.) Sep 30, 2001 - Sep 29, 2010
    NIH/NCI
    SPORE in Skin Cancer
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Divito SJ, Aasebø AT, Matos TR, Hsieh PC, Collin M, Elco CP, O'Malley JT, Bækkevold ES, Reims H, Gedde-Dahl T, Hagerstrom M, Hilaire J, Lian JW, Milford EL, Pinkus GS, Ho VT, Soiffer RJ, Kim HT, Mihm MC, Ritz J, Guleria I, Cutler CS, Clark RA, Jahnsen FL, Kupper TS. Peripheral host T cells survive hematopoietic stem cell transplantation and promote graft-versus-host disease. J Clin Invest. 2020 Sep 01; 130(9):4624-4636. PMID: 32516138.
    Citations:    
  2. Lee J, Kim B, Chu H, Zhang K, Kim H, Kim JH, Kim SH, Pan Y, Noh JY, Sun Z, Lee J, Jeong KY, Park KH, Park JW, Kupper TS, Park CO, Lee KH. FABP5 as a possible biomarker in atopic march: FABP5-induced Th17 polarization, both in mouse model and human samples. EBioMedicine. 2020 Aug; 58:102879. PMID: 32711257.
    Citations:    
  3. Tian T, Lofftus S, Pan Y, Stingley CA, King SL, Zhao J, Pan TY, Lock R, Marglous JW, Liu K, Widlund HR, Fuhlbrigge RC, Cichowski K, Kupper TS. IL1a Antagonizes IL1ß and Promotes Adaptive Immune Rejection of Malignant Tumors. Cancer Immunol Res. 2020 May; 8(5):660-671. PMID: 32161110.
    Citations:    
  4. O'Malley JT, de Masson A, Lowry EL, Giobbie-Hurder A, LeBoeuf NR, Larocca C, Gehad A, Seger E, Teague JE, Fisher DC, Kupper TS, Devlin PM, Clark RA. Radiotherapy Eradicates Malignant T Cells and Is Associated with Improved Survival in Early-Stage Mycosis Fungoides. Clin Cancer Res. 2020 01 15; 26(2):408-418. PMID: 31636100.
    Citations:    
  5. Larocca C, Kupper TS, LeBoeuf NR. Mogamulizumab Forecast: Clearer Patients, with a Slight Chance of Immune Mayhem. Clin Cancer Res. 2019 12 15; 25(24):7272-7274. PMID: 31615932.
    Citations:    
  6. Ho AW, Kupper TS. T cells and the skin: from protective immunity to inflammatory skin disorders. Nat Rev Immunol. 2019 08; 19(8):490-502. PMID: 30992525.
    Citations:    
  7. Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ. Publisher Correction: Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 2019 May; 569(7758):E12. PMID: 31081500.
    Citations:    
  8. Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ. Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 2019 02; 566(7743):259-263. PMID: 30728498.
    Citations:    
  9. Larocca C, Kupper T. Mycosis Fungoides and Sézary Syndrome: An Update. Hematol Oncol Clin North Am. 2019 02; 33(1):103-120. PMID: 30497668.
    Citations:    
  10. Aires DJ, Yoshida M, Richardson SK, Bai M, Liu L, Moreno R, Lazar AJF, Wick JA, Rich BE, Murphy G, Blumberg RS, Fuhlbrigge RC, Kupper TS. T-cell trafficking plays an essential role in tumor immunity. Lab Invest. 2019 01; 99(1):85-92. PMID: 30353131.
    Citations:    Fields:    
  11. Pan Y, Kupper TS. Metabolic Reprogramming and Longevity of Tissue-Resident Memory T Cells. Front Immunol. 2018; 9:1347. PMID: 29967608.
    Citations:    
  12. de Masson A, O'Malley JT, Elco CP, Garcia SS, Divito SJ, Lowry EL, Tawa M, Fisher DC, Devlin PM, Teague JE, Leboeuf NR, Kirsch IR, Robins H, Clark RA, Kupper TS. High-throughput sequencing of the T cell receptor ß gene identifies aggressive early-stage mycosis fungoides. Sci Transl Med. 2018 05 09; 10(440). PMID: 29743350.
    Citations:    Fields:    
  13. Nambudiri VE, Watson AJ, Rubenstein MH, Kupper TS, Yang FC. Association of Patient Satisfaction With Medical Scribe Use in an Academic Dermatology Practice. JAMA Dermatol. 2018 04 01; 154(4):480-482. PMID: 29466547.
    Citations:    Fields:    
  14. Gehad A, Teague JE, Matos TR, Huang V, Yang C, Watanabe R, O'Malley JT, Trimble CL, Kupper TS, Clark RA. A primary role for human central memory cells in tissue immunosurveillance. Blood Adv. 2018 02 13; 2(3):292-298. PMID: 29437556.
    Citations: 1     Translation:HumansAnimalsCells
  15. Nambudiri VE, Watson AJ, Buzney EA, Kupper TS, Rubenstein MH, Yang FC. Medical Scribes in an Academic Dermatology Practice. JAMA Dermatol. 2018 01 01; 154(1):101-103. PMID: 29094159.
    Citations: 1     Fields:    
  16. Park CO, Fu X, Jiang X, Pan Y, Teague JE, Collins N, Tian T, O'Malley JT, Emerson RO, Kim JH, Jung Y, Watanabe R, Fuhlbrigge RC, Carbone FR, Gebhardt T, Clark RA, Lin CP, Kupper TS. Staged development of long-lived T-cell receptor aß TH17 resident memory T-cell population to Candida albicans after skin infection. J Allergy Clin Immunol. 2018 08; 142(2):647-662. PMID: 29128674.
    Citations: 6     Fields:    
  17. Matos TR, O'Malley JT, Lowry EL, Hamm D, Kirsch IR, Robins HS, Kupper TS, Krueger JG, Clark RA. Clinically resolved psoriatic lesions contain psoriasis-specific IL-17-producing aß T cell clones. J Clin Invest. 2017 Nov 01; 127(11):4031-4041. PMID: 28945199.
    Citations: 7     Fields:    Translation:HumansCells
  18. Jain S, Washington A, Leaf RK, Bhargava P, Clark RA, Kupper TS, Stroopinsky D, Pyzer A, Cole L, Nahas M, Apel A, Rosenblatt J, Arnason J, Kufe D, Avigan D. Decitabine Priming Enhances Mucin 1 Inhibition Mediated Disruption of Redox Homeostasis in Cutaneous T-Cell Lymphoma. . 2017 10; 16(10):2304-2314. PMID: 28729399.
    Citations:    Fields:    Translation:HumansAnimalsCells
  19. Tian T, Jin MQ, Dubin K, King SL, Hoetzenecker W, Murphy GF, Chen CA, Kupper TS, Fuhlbrigge RC. IL-1R Type 1-Deficient Mice Demonstrate an Impaired Host Immune Response against Cutaneous Vaccinia Virus Infection. J Immunol. 2017 06 01; 198(11):4341-4351. PMID: 28468973.
    Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
  20. Song JS, Tawa M, Chau NG, Kupper TS, LeBoeuf NR. Aprepitant for refractory cutaneous T-cell lymphoma-associated pruritus: 4 cases and a review of the literature. BMC Cancer. 2017 03 16; 17(1):200. PMID: 28302100.
    Citations: 2     Fields:    Translation:HumansCells
  21. Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 03 09; 543(7644):252-256. PMID: 28219080.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  22. Jiang X, Park CO, Geddes Sweeney J, Yoo MJ, Gaide O, Kupper TS. Dermal ?d T Cells Do Not Freely Re-Circulate Out of Skin and Produce IL-17 to Promote Neutrophil Infiltration during Primary Contact Hypersensitivity. PLoS One. 2017; 12(1):e0169397. PMID: 28081153.
    Citations: 4     Fields:    Translation:AnimalsCells
  23. Gunasekera NS, Divito JK, Kupper TS, Huang JT, Divito SJ. Cross-Sectional Study Evaluating Skin, Hair, Nail, and Bone Disease in Patients with Focal Dermal Hypoplasia. Pediatr Dermatol. 2017 Mar; 34(2):197-198. PMID: 28025844.
    Citations:    Fields:    Translation:Humans
  24. Pallin DJ, Bry L, Dwyer RC, Lipworth AD, Leung DY, Camargo CA, Kupper TS, Filbin MR, Murphy GF. Toward an Objective Diagnostic Test for Bacterial Cellulitis. PLoS One. 2016; 11(9):e0162947. PMID: 27656884.
    Citations: 2     Fields:    
  25. Clark SL, Tse JY, Fisher DC, LeBeouf NR, Murphy GF, Kupper TS, Clark RA, Lian CG. Histopathologic spectrum of hypersensitivity reactions associated with anti-CD52 therapy (alemtuzumab). J Cutan Pathol. 2016 Nov; 43(11):989-993. PMID: 27531597.
    Citations:    Fields:    Translation:Humans
  26. Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 07 11; 30(1):183. PMID: 27479034.
    Citations: 13     Fields:    
  27. Obaitan I, Dwyer R, Lipworth AD, Kupper TS, Camargo CA, Hooper DC, Murphy GF, Pallin DJ. Failure of antibiotics in cellulitis trials: a systematic review and meta-analysis. Am J Emerg Med. 2016 Aug; 34(8):1645-52. PMID: 27344098.
    Citations: 1     Fields:    Translation:Humans
  28. Collins N, Jiang X, Zaid A, Macleod BL, Li J, Park CO, Haque A, Bedoui S, Heath WR, Mueller SN, Kupper TS, Gebhardt T, Carbone FR. Skin CD4(+) memory T cells exhibit combined cluster-mediated retention and equilibration with the circulation. Nat Commun. 2016 05 10; 7:11514. PMID: 27160938.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  29. Townsend EC, Murakami MA, Christodoulou A, Christie AL, Köster J, DeSouza TA, Morgan EA, Kallgren SP, Liu H, Wu SC, Plana O, Montero J, Stevenson KE, Rao P, Vadhi R, Andreeff M, Armand P, Ballen KK, Barzaghi-Rinaudo P, Cahill S, Clark RA, Cooke VG, Davids MS, DeAngelo DJ, Dorfman DM, Eaton H, Ebert BL, Etchin J, Firestone B, Fisher DC, Freedman AS, Galinsky IA, Gao H, Garcia JS, Garnache-Ottou F, Graubert TA, Gutierrez A, Halilovic E, Harris MH, Herbert ZT, Horwitz SM, Inghirami G, Intlekofer AM, Ito M, Izraeli S, Jacobsen ED, Jacobson CA, Jeay S, Jeremias I, Kelliher MA, Koch R, Konopleva M, Kopp N, Kornblau SM, Kung AL, Kupper TS, LeBoeuf NR, LaCasce AS, Lees E, Li LS, Look AT, Murakami M, Muschen M, Neuberg D, Ng SY, Odejide OO, Orkin SH, Paquette RR, Place AE, Roderick JE, Ryan JA, Sallan SE, Shoji B, Silverman LB, Soiffer RJ, Steensma DP, Stegmaier K, Stone RM, Tamburini J, Thorner AR, van Hummelen P, Wadleigh M, Wiesmann M, Weng AP, Wuerthner JU, Williams DA, Wollison BM, Lane AA, Letai A, Bertagnolli MM, Ritz J, Brown M, Long H, Aster JC, Shipp MA, Griffin JD, Weinstock DM. The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice. Cancer Cell. 2016 04 11; 29(4):574-586. PMID: 27070704.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  30. Timerman D, Devlin PM, Nambudiri VE, Wright NA, Vleugels RA, Clark RA, Kupper TS, Merola JF, Patel M. Novel application of high-dose rate brachytherapy for severe, recalcitrant palmoplantar pustulosis. Clin Exp Dermatol. 2016 Jul; 41(5):498-501. PMID: 26848819.
    Citations:    Fields:    Translation:Humans
  31. Romar GA, Kupper TS, Divito SJ. Research Techniques Made Simple: Techniques to Assess Cell Proliferation. J Invest Dermatol. 2016 Jan; 136(1):e1-e7. PMID: 26763463.
    Citations: 2     Fields:    Translation:Humans
  32. Goddard AL, Vleugels RA, LeBoeuf NR, O'Farrell DA, Cormack RA, Hansen JL, Kupper TS, Devlin PM. Palliative Therapy for Recalcitrant Cutaneous T-Cell Lymphoma of the Hands and Feet With Low-Dose, High Dose-Rate Brachytherapy. JAMA Dermatol. 2015 Dec 01; 151(12):1354-1357. PMID: 26397774.
    Citations: 3     Fields:    
  33. Griffin RL, Kupper TS, Divito SJ. Humanized Mice in Dermatology Research. J Invest Dermatol. 2015 Dec; 135(12):e39-e43. PMID: 26569593.
    Citations:    Fields:    Translation:HumansAnimals
  34. Kirsch IR, Watanabe R, O'Malley JT, Williamson DW, Scott LL, Elco CP, Teague JE, Gehad A, Lowry EL, LeBoeuf NR, Krueger JG, Robins HS, Kupper TS, Clark RA. TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL. Sci Transl Med. 2015 Oct 07; 7(308):308ra158. PMID: 26446955.
    Citations: 22     Fields:    Translation:HumansCells
  35. Kleffel S, Posch C, Barthel SR, Mueller H, Schlapbach C, Guenova E, Elco CP, Lee N, Juneja VR, Zhan Q, Lian CG, Thomi R, Hoetzenecker W, Cozzio A, Dummer R, Mihm MC, Flaherty KT, Frank MH, Murphy GF, Sharpe AH, Kupper TS, Schatton T. Melanoma Cell-Intrinsic PD-1 Receptor Functions Promote Tumor Growth. Cell. 2015 Sep 10; 162(6):1242-56. PMID: 26359984.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  36. Schatton T, Yang J, Kleffel S, Uehara M, Barthel SR, Schlapbach C, Zhan Q, Dudeney S, Mueller H, Lee N, de Vries JC, Meier B, Vander Beken S, Kluth MA, Ganss C, Sharpe AH, Waaga-Gasser AM, Sayegh MH, Abdi R, Scharffetter-Kochanek K, Murphy GF, Kupper TS, Frank NY, Frank MH. ABCB5 Identifies Immunoregulatory Dermal Cells. Cell Rep. 2015 Sep 08; 12(10):1564-74. PMID: 26321644.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  37. Park CO, Kupper TS. The emerging role of resident memory T cells in protective immunity and inflammatory disease. Nat Med. 2015 Jul; 21(7):688-97. PMID: 26121195.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  38. Jain S, Stroopinsky D, Yin L, Rosenblatt J, Alam M, Bhargava P, Clark RA, Kupper TS, Palmer K, Coll MD, Rajabi H, Pyzer A, Bar-Natan M, Luptakova K, Arnason J, Joyce R, Kufe D, Avigan D. Mucin 1 is a potential therapeutic target in cutaneous T-cell lymphoma. Blood. 2015 Jul 16; 126(3):354-62. PMID: 26048911.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  39. Gaide O, Emerson RO, Jiang X, Gulati N, Nizza S, Desmarais C, Robins H, Krueger JG, Clark RA, Kupper TS. Common clonal origin of central and resident memory T cells following skin immunization. Nat Med. 2015 Jun; 21(6):647-53. PMID: 25962122.
    Citations: 44     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  40. Nambudiri VE, Dwyer RC, Camargo CA, Kupper TS, Pallin DJ. Outcome assessment in cellulitis clinical trials: is telephone follow up sufficient? Clin Microbiol Infect. 2015 Jul; 21(7):676.e5-7. PMID: 25882364.
    Citations: 1     Fields:    Translation:Humans
  41. Watanabe R, Gehad A, Yang C, Scott LL, Teague JE, Schlapbach C, Elco CP, Huang V, Matos TR, Kupper TS, Clark RA. Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells. Sci Transl Med. 2015 Mar 18; 7(279):279ra39. PMID: 25787765.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  42. Litvinov IV, Netchiporouk E, Cordeiro B, Doré MA, Moreau L, Pehr K, Gilbert M, Zhou Y, Sasseville D, Kupper TS. The Use of Transcriptional Profiling to Improve Personalized Diagnosis and Management of Cutaneous T-cell Lymphoma (CTCL). Clin Cancer Res. 2015 Jun 15; 21(12):2820-9. PMID: 25779945.
    Citations: 11     Fields:    Translation:Humans
  43. Bhela S, Kempsell C, Manohar M, Dominguez-Villar M, Griffin R, Bhatt P, Kivisakk-Webb P, Fuhlbrigge R, Kupper T, Weiner H, Baecher-Allan C. Nonapoptotic and extracellular activity of granzyme B mediates resistance to regulatory T cell (Treg) suppression by HLA-DR-CD25hiCD127lo Tregs in multiple sclerosis and in response to IL-6. J Immunol. 2015 Mar 01; 194(5):2180-9. PMID: 25637022.
    Citations: 13     Fields:    Translation:HumansCells
  44. Litvinov IV, Netchiporouk E, Cordeiro B, Zargham H, Pehr K, Gilbert M, Zhou Y, Moreau L, Woetmann A, Ødum N, Kupper TS, Sasseville D. Ectopic expression of embryonic stem cell and other developmental genes in cutaneous T-cell lymphoma. Oncoimmunology. 2014 Nov; 3(11):e970025. PMID: 25941598.
    Citations: 12     
  45. Retraction: Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2014 Nov; 124(11):5085. PMID: 25365075.
    Citations:    Fields:    
  46. Kupper TS. Personal reflections on 25 years of immunodermatology. Br J Dermatol. 2014 Oct; 171(4):684-6. PMID: 25319418.
    Citations:    Fields:    Translation:Humans
  47. Divito SJ, Kupper TS. Inhibiting Janus kinases to treat alopecia areata. Nat Med. 2014 Sep; 20(9):989-90. PMID: 25198048.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  48. Watanabe R, Teague JE, Fisher DC, Kupper TS, Clark RA. Alemtuzumab therapy for leukemic cutaneous T-cell lymphoma: diffuse erythema as a positive predictor of complete remission. JAMA Dermatol. 2014 Jul; 150(7):776-9. PMID: 24760312.
    Citations: 4     Fields:    Translation:Humans
  49. Huang Y, Litvinov IV, Wang Y, Su MW, Tu P, Jiang X, Kupper TS, Dutz JP, Sasseville D, Zhou Y. Thymocyte selection-associated high mobility group box gene (TOX) is aberrantly over-expressed in mycosis fungoides and correlates with poor prognosis. Oncotarget. 2014 Jun 30; 5(12):4418-25. PMID: 24947046.
    Citations: 12     Fields:    Translation:HumansCells
  50. Tuzova M, Richmond J, Wolpowitz D, Curiel-Lewandrowski C, Chaney K, Kupper T, Cruikshank W. CCR4+T cell recruitment to the skin in mycosis fungoides: potential contributions by thymic stromal lymphopoietin and interleukin-16. Leuk Lymphoma. 2015 Feb; 56(2):440-9. PMID: 24794807.
    Citations: 2     Fields:    Translation:HumansCells
  51. Litvinov IV, Cordeiro B, Huang Y, Zargham H, Pehr K, Doré MA, Gilbert M, Zhou Y, Kupper TS, Sasseville D. Ectopic expression of cancer-testis antigens in cutaneous T-cell lymphoma patients. Clin Cancer Res. 2014 Jul 15; 20(14):3799-808. PMID: 24850846.
    Citations: 14     Fields:    Translation:HumansCells
  52. Schlapbach C, Gehad A, Yang C, Watanabe R, Guenova E, Teague JE, Campbell L, Yawalkar N, Kupper TS, Clark RA. Human TH9 cells are skin-tropic and have autocrine and paracrine proinflammatory capacity. Sci Transl Med. 2014 Jan 15; 6(219):219ra8. PMID: 24431112.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  53. Litvinov IV, Cordeiro B, Fredholm S, Ødum N, Zargham H, Huang Y, Zhou Y, Pehr K, Kupper TS, Woetmann A, Sasseville D. Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines. . 2014; 13(18):2975-82. PMID: 25486484.
    Citations: 13     Fields:    Translation:HumansCells
  54. Li WQ, Han J, Widlund HR, Correll M, Wang YE, Quackenbush J, Mihm MC, Canales AL, Wu S, Golub T, Hoshida Y, Hunter DJ, Murphy G, Kupper TS, Qureshi AA. CXCR4 pathway associated with family history of melanoma. Cancer Causes Control. 2014 Jan; 25(1):125-32. PMID: 24158781.
    Citations: 1     Fields:    Translation:HumansCells
  55. Seneschal J, Jiang X, Kupper TS. Langerin+ dermal DC, but not Langerhans cells, are required for effective CD8-mediated immune responses after skin scarification with vaccinia virus. J Invest Dermatol. 2014 Mar; 134(3):686-694. PMID: 24126845.
    Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
  56. Vander Lugt B, Tubo NJ, Nizza ST, Boes M, Malissen B, Fuhlbrigge RC, Kupper TS, Campbell JJ. CCR7 plays no appreciable role in trafficking of central memory CD4 T cells to lymph nodes. J Immunol. 2013 Sep 15; 191(6):3119-27. PMID: 23935190.
    Citations: 18     Fields:    Translation:AnimalsCells
  57. Guenova E, Watanabe R, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, Fisher DC, Kupper TS, Clark RA. TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res. 2013 Jul 15; 19(14):3755-63. PMID: 23785046.
    Citations: 26     Fields:    Translation:HumansCells
  58. Hu L, Haynes H, Ferrazza D, Kupper T, Qureshi A. Impact of specialist consultations on inpatient admissions for dermatology-specific and related DRGs. J Gen Intern Med. 2013 Nov; 28(11):1477-82. PMID: 23709404.
    Citations: 1     Fields:    Translation:Humans
  59. DeSimone JA, Guenova E, Carter JB, Chaney KS, Aldridge JR, Noell CM, Dorosario AA, Hansen JL, Kupper TS, Devlin PM. Low-dose high-dose-rate brachytherapy in the treatment of facial lesions of cutaneous T-cell lymphoma. J Am Acad Dermatol. 2013 Jul; 69(1):61-5. PMID: 23453243.
    Citations: 2     Fields:    Translation:Humans
  60. Hijnen D, Knol EF, Gent YY, Giovannone B, Beijn SJ, Kupper TS, Bruijnzeel-Koomen CA, Clark RA. CD8(+) T cells in the lesional skin of atopic dermatitis and psoriasis patients are an important source of IFN-?, IL-13, IL-17, and IL-22. J Invest Dermatol. 2013 Apr; 133(4):973-9. PMID: 23223131.
    Citations: 40     Fields:    Translation:HumansCells
  61. Litvinov IV, Kupper TS, Sasseville D. The role of AHI1 and CDKN1C in cutaneous T-cell lymphoma progression. Exp Dermatol. 2012 Dec; 21(12):964-6. PMID: 23171462.
    Citations: 13     Fields:    Translation:Humans
  62. Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrel C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui R, Han J, Fisher DE, Arany Z. PGC-1 coactivators regulate MITF and the tanning response. Mol Cell. 2013 Jan 10; 49(1):145-57. PMID: 23201126.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  63. Rodig SJ, Cheng J, Wardzala J, DoRosario A, Scanlon JJ, Laga AC, Martinez-Fernandez A, Barletta JA, Bellizzi AM, Sadasivam S, Holloway DT, Cooper DJ, Kupper TS, Wang LC, DeCaprio JA. Improved detection suggests all Merkel cell carcinomas harbor Merkel polyomavirus. J Clin Invest. 2012 Dec; 122(12):4645-53. PMID: 23114601.
    Citations: 53     Fields:    Translation:HumansCells
  64. Alloo A, DeSimone JA, Kupper TS. Mycosis fungoides presenting at the site of a transdermal estradiol patch. J Am Acad Dermatol. 2012 Nov; 67(5):e207-8. PMID: 23062916.
    Citations: 1     Fields:    Translation:Humans
  65. Han T, Abdel-Motal UM, Chang DK, Sui J, Muvaffak A, Campbell J, Zhu Q, Kupper TS, Marasco WA. Human anti-CCR4 minibody gene transfer for the treatment of cutaneous T-cell lymphoma. PLoS One. 2012; 7(9):e44455. PMID: 22973452.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  66. Litvinov IV, Zhou Y, Kupper TS, Sasseville D. Loss of BCL7A expression correlates with poor disease prognosis in patients with early-stage cutaneous T-cell lymphoma. Leuk Lymphoma. 2013 Mar; 54(3):653-4. PMID: 22856870.
    Citations: 13     Fields:    Translation:Humans
  67. Chang DK, Sui J, Geng S, Muvaffak A, Bai M, Fuhlbrigge RC, Lo A, Yammanuru A, Hubbard L, Sheehan J, Campbell JJ, Zhu Q, Kupper TS, Marasco WA. Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells. . 2012 Nov; 11(11):2451-61. PMID: 22869555.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  68. Velez NF, Ishizawar RC, Dellaripa PF, Saavedra AP, Laga AC, Murphy GF, Fisher DC, Kupper TS, Vleugels RA. Full facial edema: a novel presentation of subcutaneous panniculitis-like T-cell lymphoma. J Clin Oncol. 2012 Sep 01; 30(25):e233-6. PMID: 22826278.
    Citations: 2     Fields:    Translation:Humans
  69. Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med. 2012 Aug; 18(8):1248-53. PMID: 22772464.
    Citations: 90     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  70. Seneschal J, Clark RA, Gehad A, Baecher-Allan CM, Kupper TS. Human epidermal Langerhans cells maintain immune homeostasis in skin by activating skin resident regulatory T cells. Immunity. 2012 May 25; 36(5):873-84. PMID: 22560445.
    Citations: 100     Fields:    Translation:HumansCells
  71. Cedeno-Laurent F, Watanabe R, Teague JE, Kupper TS, Clark RA, Dimitroff CJ. Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma. Blood. 2012 Apr 12; 119(15):3534-8. PMID: 22383798.
    Citations: 16     Fields:    Translation:HumansCells
  72. Müller J, Friedrich M, Becher T, Braunstein J, Kupper T, Berdel P, Gravius S, Rohrbach F, Oldenburg J, Mayer G, Pötzsch B. Monitoring of plasma levels of activated protein C using a clinically applicable oligonucleotide-based enzyme capture assay. J Thromb Haemost. 2012 Mar; 10(3):390-8. PMID: 22236082.
    Citations: 5     Fields:    Translation:HumansCells
  73. Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS. Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature. 2012 Feb 29; 483(7388):227-31. PMID: 22388819.
    Citations: 227     Fields:    Translation:AnimalsCells
  74. Tian T, Dubin K, Jin Q, Qureshi A, King SL, Liu L, Jiang X, Murphy GF, Kupper TS, Fuhlbrigge RC. Disruption of TNF-a/TNFR1 function in resident skin cells impairs host immune response against cutaneous vaccinia virus infection. J Invest Dermatol. 2012 May; 132(5):1425-34. PMID: 22318381.
    Citations: 3     Fields:    Translation:AnimalsCells
  75. Clark RA, Watanabe R, Teague JE, Schlapbach C, Tawa MC, Adams N, Dorosario AA, Chaney KS, Cutler CS, Leboeuf NR, Carter JB, Fisher DC, Kupper TS. Skin effector memory T cells do not recirculate and provide immune protection in alemtuzumab-treated CTCL patients. Sci Transl Med. 2012 Jan 18; 4(117):117ra7. PMID: 22261031.
    Citations: 77     Fields:    Translation:HumansCells
  76. Kupper TS. Old and new: recent innovations in vaccine biology and skin T cells. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):829-34. PMID: 22237702.
    Citations: 10     Fields:    Translation:HumansCells
  77. Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49. PMID: 22080865.
    Citations: 2     Fields:    Translation:HumansCells
  78. Purwar R, Campbell J, Murphy G, Richards WG, Clark RA, Kupper TS. Resident memory T cells (T(RM)) are abundant in human lung: diversity, function, and antigen specificity. PLoS One. 2011 Jan 26; 6(1):e16245. PMID: 21298112.
    Citations: 93     Fields:    Translation:HumansCells
  79. Frank NY, Schatton T, Kim S, Zhan Q, Wilson BJ, Ma J, Saab KR, Osherov V, Widlund HR, Gasser M, Waaga-Gasser AM, Kupper TS, Murphy GF, Frank MH. VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res. 2011 Feb 15; 71(4):1474-85. PMID: 21212411.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  80. Clark RA, Shackelton JB, Watanabe R, Calarese A, Yamanaka K, Campbell JJ, Teague JE, Kuo HP, Hijnen D, Kupper TS. High-scatter T cells: a reliable biomarker for malignant T cells in cutaneous T-cell lymphoma. Blood. 2011 Feb 10; 117(6):1966-76. PMID: 21148332.
    Citations: 10     Fields:    Translation:HumansCells
  81. Richmond J, Tuzova M, Parks A, Adams N, Martin E, Tawa M, Morrison L, Chaney K, Kupper TS, Curiel-Lewandrowski C, Cruikshank W. Interleukin-16 as a marker of Sézary syndrome onset and stage. J Clin Immunol. 2011 Feb; 31(1):39-50. PMID: 20878214.
    Citations: 10     Fields:    Translation:Humans
  82. Campbell JJ, Clark RA, Watanabe R, Kupper TS. Sezary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors. Blood. 2010 Aug 05; 116(5):767-71. PMID: 20484084.
    Citations: 63     Fields:    Translation:HumansCells
  83. Jiang X, Campbell JJ, Kupper TS. Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4. Proc Natl Acad Sci U S A. 2010 Apr 20; 107(16):7443-8. PMID: 20368416.
    Citations: 20     Fields:    Translation:AnimalsCells
  84. van Geel NA, Mollet IG, De Schepper S, Tjin EP, Vermaelen K, Clark RA, Kupper TS, Luiten RM, Lambert J. First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. Pigment Cell Melanoma Res. 2010 Jun; 23(3):375-84. PMID: 20370855.
    Citations: 9     Fields:    Translation:HumansCells
  85. Litvinov IV, Jones DA, Sasseville D, Kupper TS. Transcriptional profiles predict disease outcome in patients with cutaneous T-cell lymphoma. Clin Cancer Res. 2010 Apr 01; 16(7):2106-14. PMID: 20233883.
    Citations: 27     Fields:    Translation:HumansCells
  86. Yamanaka KI, Kakeda M, Kitagawa H, Tsuda K, Akeda T, Kurokawa I, Gabazza EC, Kupper TS, Mizutani H. 1,24-Dihydroxyvitamin D3 (tacalcitol) prevents skin T-cell infiltration. Br J Dermatol. 2010 Jun; 162(6):1206-15. PMID: 20163421.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  87. Yamanaka K, Fuhlbrigge RC, Mizutani H, Kupper TS. Restoration of peripheral blood T cell repertoire complexity during remission in advanced cutaneous T cell lymphoma. Arch Dermatol Res. 2010 Aug; 302(6):453-9. PMID: 20111968.
    Citations: 3     Fields:    Translation:HumansCells
  88. Liu L, Zhong Q, Tian T, Dubin K, Athale SK, Kupper TS. Epidermal injury and infection during poxvirus immunization is crucial for the generation of highly protective T cell-mediated immunity. Nat Med. 2010 Feb; 16(2):224-7. PMID: 20081864.
    Citations: 91     Fields:    Translation:AnimalsCells
  89. Huang SJ, Hijnen D, Murphy GF, Kupper TS, Calarese AW, Mollet IG, Schanbacher CF, Miller DM, Schmults CD, Clark RA. Imiquimod enhances IFN-gamma production and effector function of T cells infiltrating human squamous cell carcinomas of the skin. J Invest Dermatol. 2009 Nov; 129(11):2676-85. PMID: 19516264.
    Citations: 26     Fields:    Translation:HumansCells
  90. Bianchi T, Pincus LB, Wurbel MA, Rich BE, Kupper TS, Fuhlbrigge RC, Boes M. Maintenance of peripheral tolerance through controlled tissue homing of antigen-specific T cells in K14-mOVA mice. J Immunol. 2009 Apr 15; 182(8):4665-74. PMID: 19342642.
    Citations: 11     Fields:    Translation:AnimalsCells
  91. Cheaib Z, Grandjean D, Kupper T, de Alencastro LF. Brominated flame retardants in fish of Lake Geneva (Switzerland). Bull Environ Contam Toxicol. 2009 Apr; 82(4):522-7. PMID: 19142559.
    Citations: 1     Fields:    Translation:AnimalsPHPublic Health
  92. Clark RA, Huang SJ, Murphy GF, Mollet IG, Hijnen D, Muthukuru M, Schanbacher CF, Edwards V, Miller DM, Kim JE, Lambert J, Kupper TS. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med. 2008 Sep 29; 205(10):2221-34. PMID: 18794336.
    Citations: 63     Fields:    Translation:HumansCells
  93. Kimball AB, Kupper TS. Future perspectives/quo vadis psoriasis treatment? Immunology, pharmacogenomics, and epidemiology. Clin Dermatol. 2008 Sep-Oct; 26(5):554-61. PMID: 18755375.
    Citations:    Fields:    Translation:HumansCells
  94. Tian T, Liu L, Freyschmidt EJ, Murphy GF, Kupper TS, Fuhlbrigge RC. Overexpression of IL-1alpha in skin differentially modulates the immune response to scarification with vaccinia virus. J Invest Dermatol. 2009 Jan; 129(1):70-8. PMID: 18615110.
    Citations: 9     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  95. Kupper T, Bucheli TD, Brändli RC, Ortelli D, Edder P. Dissipation of pesticides during composting and anaerobic digestion of source-separated organic waste at full-scale plants. Bioresour Technol. 2008 Nov; 99(17):7988-94. PMID: 18455393.
    Citations: 2     Fields:    Translation:CellsPHPublic Health
  96. Bester K, Klasmeier J, Kupper T. Emissions of OTNE (Iso-E-super) - mass flows in sewage treatment plants. Chemosphere. 2008 May; 71(11):2003-10. PMID: 18359059.
    Citations: 1     Fields:    Translation:CellsPHPublic Health
  97. Schatton T, Murphy GF, Frank NY, Yamaura K, Waaga-Gasser AM, Gasser M, Zhan Q, Jordan S, Duncan LM, Weishaupt C, Fuhlbrigge RC, Kupper TS, Sayegh MH, Frank MH. Identification of cells initiating human melanomas. Nature. 2008 Jan 17; 451(7176):345-9.