Harvard Catalyst Profiles

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Raouf A. Khalil, Ph.D., M.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL147889 (KHALIL, RAOUF A) Sep 1, 2020 - Aug 31, 2023
    NIH
    Vascular Mechanisms of Hypertension-in-Pregnancy
    Role: Principal Investigator
  2. R56HL147889 (KHALIL, RAOUF A) Sep 20, 2019 - Aug 31, 2020
    NIH
    Vascular Mechanisms of Hypertension-in-Pregnancy
    Role: Principal Investigator
  3. R21HL111775 (KHALIL, RAOUF A) Feb 1, 2013 - Jan 31, 2017
    NIH
    Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous Insufficiency
    Role: Principal Investigator
  4. R21HL098724 (KHALIL, RAOUF A.) Aug 6, 2010 - Feb 1, 2014
    NIH
    Role of Endothelin B Receptor in Vascular Protection in Females
    Role: Principal Investigator
  5. R03HD060702 (KHALIL, RAOUF A.) May 8, 2009 - Apr 30, 2012
    NIH
    Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Khalil RA. Emerging mechanisms in the pathogenesis of hypertension. Biochem Pharmacol. 2023 Jan 13; 209:115416. PMID: 36646292.
    Citations:    Fields:    
  2. Mazzuca MQ, Buyukcelebi K, Lin C, Khalil RA. Increased Ca2+-dependent intrinsic tone and arterial stiffness in mesenteric microvessels of hypertensive pregnant rats. Biochem Pharmacol. 2023 02; 208:115353. PMID: 36435203; PMCID: PMC9877182.
    Citations:    Fields:    Translation:Animals
  3. Qu H, Khalil RA. Role of ADAM and ADAMTS disintegrin and metalloproteinases in normal pregnancy and preeclampsia. Biochem Pharmacol. 2022 12; 206:115266. PMID: 36191626.
    Citations:    Fields:    Translation:Humans
  4. Yin Z, Su J, Fei J, Li T, Li D, Cao Y, Khalil RA. Preserved oxytocin-induced myometrium contraction and sensitivity to progesterone inhibition following rat uterus thermal insult. Impact on fertility. Biochem Pharmacol. 2022 Oct; 204:115244. PMID: 36087639.
    Citations:    Fields:    Translation:Animals
  5. Christou H, Khalil RA. Mechanisms of pulmonary vascular dysfunction in pulmonary hypertension and implications for novel therapies. Am J Physiol Heart Circ Physiol. 2022 05 01; 322(5):H702-H724. PMID: 35213243; PMCID: PMC8977136.
    Citations:    Fields:    Translation:HumansCells
  6. Yang H, Khalil RA. ADAM and ADAMTS disintegrin and metalloproteinases as major factors and molecular targets in vascular malfunction and disease. Adv Pharmacol. 2022; 94:255-363. PMID: 35659374; PMCID: PMC9231755.
    Citations:    Fields:    Translation:Humans
  7. Ren Z, Cui N, Zhu M, Khalil RA. TNFa blockade reverses vascular and uteroplacental matrix metalloproteinases imbalance and collagen accumulation in hypertensive pregnant rats. Biochem Pharmacol. 2021 11; 193:114790. PMID: 34600915; PMCID: PMC8606001.
    Citations:    Fields:    Translation:Animals
  8. Raffetto JD, Khalil RA. Mechanisms of Lower Extremity Vein Dysfunction in Chronic Venous Disease and Implications in Management of Varicose Veins. Vessel Plus. 2021; 5. PMID: 34250453.
    Citations: 2     
  9. Chen T, Ye B, Tan J, Yang H, He F, Khalil RA. CD146+Mesenchymal stem cells treatment improves vascularization, muscle contraction and VEGF expression, and reduces apoptosis in rat ischemic hind limb. Biochem Pharmacol. 2021 08; 190:114530. PMID: 33891966; PMCID: PMC8316322.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Christou H, Michael Z, Spyropoulos F, Chen Y, Rong D, Khalil RA. Carbonic anhydrase inhibition improves pulmonary artery reactivity and nitric oxide-mediated relaxation in sugen-hypoxia model of pulmonary hypertension. Am J Physiol Regul Integr Comp Physiol. 2021 06 01; 320(6):R835-R850. PMID: 33826428; PMCID: PMC8285620.
    Citations: 2     Fields:    Translation:Animals
  11. Raffetto JD, Ligi D, Maniscalco R, Khalil RA, Mannello F. Why Venous Leg Ulcers Have Difficulty Healing: Overview on Pathophysiology, Clinical Consequences, and Treatment. J Clin Med. 2020 Dec 24; 10(1). PMID: 33374372.
    Citations: 10     
  12. Zhang N, Tan J, Yang H, Khalil RA. Comparative risks and predictors of preeclamptic pregnancy in the Eastern, Western and developing world. Biochem Pharmacol. 2020 12; 182:114247. PMID: 32986983; PMCID: PMC7686229.
    Citations: 1     Fields:    Translation:Humans
  13. Qu H, Khalil RA. Vascular mechanisms and molecular targets in hypertensive pregnancy and preeclampsia. Am J Physiol Heart Circ Physiol. 2020 09 01; 319(3):H661-H681. PMID: 32762557.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  14. Li L, Ma W, Pan S, Li Y, Wang H, Wang B, Khalil RA. MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression. J Cell Mol Med. 2020 07; 24(14):7896-7906. PMID: 32469162.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  15. Li Y, Wang W, Li L, Khalil RA. MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm. Life Sci. 2020 Jul 15; 253:117659. PMID: 32283055.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  16. Raffetto JD, Yu W, Wang X, Calanni F, Mattana P, Khalil RA. Sulodexide Improves Contraction and Decreases Matrix Metalloproteinase-2 and -9 in Veins Under Prolonged Stretch. J Cardiovasc Pharmacol. 2020 03; 75(3):211-221. PMID: 31738197; PMCID: PMC7060112.
    Citations: 4     Fields:    Translation:AnimalsCells
  17. Lin C, He H, Cui N, Ren Z, Zhu M, Khalil RA. Decreased uterine vascularization and uterine arterial expansive remodeling with reduced matrix metalloproteinase-2 and -9 in hypertensive pregnancy. Am J Physiol Heart Circ Physiol. 2020 01 01; 318(1):H165-H180. PMID: 31834839.
    Citations: 10     Fields:    Translation:AnimalsCells
  18. Raffetto JD, Calanni F, Mattana P, Khalil RA. Sulodexide promotes arterial relaxation via endothelium-dependent nitric oxide-mediated pathway. Biochem Pharmacol. 2019 08; 166:347-356. PMID: 31014752.
    Citations: 9     Fields:    Translation:AnimalsCells
  19. Zhong S, Khalil RA. A Disintegrin and Metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) family in vascular biology and disease. Biochem Pharmacol. 2019 06; 164:188-204. PMID: 30905657.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  20. Yu W, Gao W, Rong D, Wu Z, Khalil RA. Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia. Microcirculation. 2018 Oct 19; e12508. PMID: 30338879; PMCID: PMC6474836.
    Citations: 10     Fields:    
  21. Ren Z, Cui N, Zhu M, Khalil RA. Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in hypertensive pregnancy. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H33-H47. PMID: 29569955; PMCID: PMC6087780.
    Citations: 11     Fields:    Translation:Animals
  22. Yin Z, He W, Li Y, Li D, Li H, Yang Y, Wei Z, Shen B, Wang X, Cao Y, Khalil RA. Adaptive reduction of human myometrium contractile activity in response to prolonged uterine stretch during term and twin pregnancy. Role of TREK-1 channel. Biochem Pharmacol. 2018 06; 152:252-263. PMID: 29577872; PMCID: PMC5960639.
    Citations: 4     Fields:    Translation:Humans
  23. Liu Z, Khalil RA. Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease. Biochem Pharmacol. 2018 07; 153:91-122. PMID: 29452094.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  24. Khalil RA. Preface. Adv Pharmacol. 2018; 81:xi-xii. PMID: 29310806.
    Citations:    Fields:    
  25. Yin Z, Li Y, He W, Li D, Li H, Yang Y, Shen B, Wang X, Cao Y, Khalil RA. Progesterone inhibits contraction and increases TREK-1 potassium channel expression in late pregnant rat uterus. Oncotarget. 2018 Jan 02; 9(1):651-661. PMID: 29416642; PMCID: PMC5787496.
    Citations: 4     Fields:    
  26. Christou H, Hudalla H, Michael Z, Filatava EJ, Li J, Zhu M, Possomato-Vieira JS, Dias-Junior C, Kourembanas S, Khalil RA. Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model. J Pharmacol Exp Ther. 2018 02; 364(2):258-274. PMID: 29212831; PMCID: PMC5774216.
    Citations: 10     Fields:    Translation:AnimalsCells
  27. Liu J, Jia X, Jia S, Qin X, Zhang T, Liu L, Li H, Rong D, Zhou Z, Song Y, Zuo S, Duan C, Wu Z, Wei R, Ge Y, Wang X, Kong W, Xu X, Khalil RA, Huo Y, Guo W. Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults. Sci Rep. 2017 11 06; 7(1):14547. PMID: 29109408.
    Citations:    Fields:    Translation:Humans
  28. Wang X, Khalil RA. Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. Adv Pharmacol. 2018; 81:241-330. PMID: 29310800; PMCID: PMC5765875.
    Citations: 118     Fields:    Translation:HumansAnimals
  29. Dias-Junior CA, Chen J, Cui N, Chiang CL, Zhu M, Ren Z, Possomato-Vieira JS, Khalil RA. Angiogenic imbalance and diminished matrix metalloproteinase-2 and -9 underlie regional decreases in uteroplacental vascularization and feto-placental growth in hypertensive pregnancy. Biochem Pharmacol. 2017 12 15; 146:101-116. PMID: 28912068; PMCID: PMC5705464.
    Citations: 7     Fields:    Translation:Animals
  30. Li W, Cui N, Mazzuca MQ, Mata KM, Khalil RA. Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-a. Am J Physiol Heart Circ Physiol. 2017 Sep 01; 313(3):H491-H507. PMID: 28626073; PMCID: PMC5625170.
    Citations: 13     Fields:    Translation:AnimalsCells
  31. Chen J, Khalil RA. Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia. Prog Mol Biol Transl Sci. 2017; 148:87-165. PMID: 28662830.
    Citations: 65     Fields:    Translation:HumansAnimals
  32. Chen J, Ren Z, Zhu M, Khalil RA. Decreased homodimerization and increased TIMP-1 complexation of uteroplacental and uterine arterial matrix metalloproteinase-9 during hypertension-in-pregnancy. Biochem Pharmacol. 2017 08 15; 138:81-95. PMID: 28506758; PMCID: PMC5516730.
    Citations: 7     Fields:    Translation:AnimalsCells
  33. Liu J, Khalil RA. Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders. Prog Mol Biol Transl Sci. 2017; 148:355-420. PMID: 28662828.
    Citations: 45     Fields:    Translation:HumansAnimals
  34. Rong D, Liu J, Jia X, Al-Nafisee D, Jia S, Sun G, Li Y, Lu W, Li H, Zhang H, Ma X, Xiong J, Liu X, Khalil RA, Guo W. Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease in a Chinese Han population. Atherosclerosis. 2017 08; 263:205-210. PMID: 28651188; PMCID: PMC5557685.
    Citations: 11     Fields:    Translation:Humans
  35. Cui N, Hu M, Khalil RA. Biochemical and Biological Attributes of Matrix Metalloproteinases. Prog Mol Biol Transl Sci. 2017; 147:1-73. PMID: 28413025.
    Citations: 250     Fields:    Translation:HumansAnimalsCells
  36. Chen Y, Peng W, Raffetto JD, Khalil RA. Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease. Prog Mol Biol Transl Sci. 2017; 147:267-299. PMID: 28413031.
    Citations: 15     Fields:    Translation:HumansAnimals
  37. Khalil RA. Preface. Adv Pharmacol. 2017; 78:xi-xii. PMID: 28212805.
    Citations:    Fields:    
  38. Khalil RA. Preface. Prog Mol Biol Transl Sci. 2017; 147:xi-xii. PMID: 28413033.
    Citations:    Fields:    Translation:HumansAnimals
  39. Ren Z, Chen J, Khalil RA. Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors. Methods Mol Biol. 2017; 1626:79-102. PMID: 28608202; PMCID: PMC5527288.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  40. Khalil RA. Preface. Prog Mol Biol Transl Sci. 2017; 148:xi-xii. PMID: 28662831.
    Citations:    Fields:    Translation:HumansAnimals
  41. Anwar MA, Vorkas PA, Li J, Adesina-Georgiadis KN, Reslan OM, Raffetto JD, Want EJ, Khalil RA, Holmes E, Davies AH. Prolonged Mechanical Circumferential Stretch Induces Metabolic Changes in Rat Inferior Vena Cava. Eur J Vasc Endovasc Surg. 2016 Oct; 52(4):544-552. PMID: 27523725.
    Citations: 1     Fields:    Translation:Animals
  42. Ringvold HC, Khalil RA. Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders. Adv Pharmacol. 2017; 78:203-301. PMID: 28212798; PMCID: PMC5319769.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  43. Possomato-Vieira JS, Khalil RA. Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia. Adv Pharmacol. 2016; 77:361-431. PMID: 27451103; PMCID: PMC4965238.
    Citations: 49     Fields:    Translation:HumansAnimals
  44. Zhu M, Ren Z, Possomato-Vieira JS, Khalil RA. Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2016 09 01; 311(3):R505-21. PMID: 27280428; PMCID: PMC5142222.
    Citations: 23     Fields:    Translation:Animals
  45. Xia Y, Khalil RA. Pregnancy-associated adaptations in [Ca2+]i-dependent and Ca2+ sensitization mechanisms of venous contraction: implications in pregnancy-related venous disorders. Am J Physiol Heart Circ Physiol. 2016 06 01; 310(11):H1851-65. PMID: 27199130; PMCID: PMC4935520.
    Citations:    Fields:    Translation:Animals
  46. Khalil RA. Preface. Adv Pharmacol. 2016; 77:xiii-xiv. PMID: 27451104.
    Citations:    Fields:    
  47. Mata KM, Li W, Reslan OM, Siddiqui WT, Opsasnick LA, Khalil RA. Adaptive increases in expression and vasodilator activity of estrogen receptor subtypes in a blood vessel-specific pattern during pregnancy. Am J Physiol Heart Circ Physiol. 2015 Nov 15; 309(10):H1679-96. PMID: 26408543; PMCID: PMC4666980.
    Citations: 14     Fields:    Translation:Animals
  48. MacColl E, Khalil RA. Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease. J Pharmacol Exp Ther. 2015 Dec; 355(3):410-28. PMID: 26319699; PMCID: PMC4658486.
    Citations: 27     Fields:    Translation:HumansAnimals
  49. Ali SM, Khalil RA. Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy. Expert Opin Ther Targets. 2015; 19(11):1495-515. PMID: 26294111; PMCID: PMC4640938.
    Citations: 25     Fields:    Translation:HumansAnimals
  50. Pojoga LH, Yao TM, Opsasnick LA, Siddiqui WT, Reslan OM, Adler GK, Williams GH, Khalil RA. Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide-High Angiotensin II-Induced Cardiovascular Injury. J Pharmacol Exp Ther. 2015 Oct; 355(1):32-47. PMID: 26183312; PMCID: PMC4576669.
    Citations: 7     Fields:    Translation:AnimalsCells
  51. Garza AE, Pojoga LH, Moize B, Hafiz WM, Opsasnick LA, Siddiqui WT, Horenstein M, Adler GK, Williams GH, Khalil RA. Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake. Hypertension. 2015 Sep; 66(3):674-80. PMID: 26169051.
    Citations: 11     Fields:    Translation:Animals
  52. Shah DA, Khalil RA. Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia. Biochem Pharmacol. 2015 Jun 15; 95(4):211-26. PMID: 25916268; PMCID: PMC4449835.
    Citations: 58     Fields:    Translation:HumansAnimals
  53. Mazzuca MQ, Mata KM, Li W, Rangan SS, Khalil RA. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther. 2015 Feb; 352(2):291-304. PMID: 25472954; PMCID: PMC4293436.
    Citations: 19     Fields:    Translation:Animals
  54. Mazzuca MQ, Li W, Reslan OM, Yu P, Mata KM, Khalil RA. Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy. Hypertension. 2014 Sep; 64(3):632-43. PMID: 24914193.
    Citations: 37     Fields:    Translation:AnimalsCells
  55. Li W, Mata KM, Mazzuca MQ, Khalil RA. Altered matrix metalloproteinase-2 and -9 expression/activity links placental ischemia and anti-angiogenic sFlt-1 to uteroplacental and vascular remodeling and collagen deposition in hypertensive pregnancy. Biochem Pharmacol. 2014 Jun 01; 89(3):370-85. PMID: 24704473.
    Citations: 34     Fields:    Translation:Animals
  56. Ou M, Dang Y, Mazzuca MQ, Basile R, Khalil RA. Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol. 2014 Apr; 229(4):489-501. PMID: 24105843.
    Citations: 8     Fields:    Translation:AnimalsCells
  57. Khalil RA. Understanding basic muscle electrophysiology while keeping an eye on diseases of the heart, lung and blood. Recent Pat Cardiovasc Drug Discov. 2014; 9(1):1. PMID: 25600348.
    Citations:    Fields:    Translation:Humans
  58. Pojoga LH, Yao TM, Opsasnick LA, Garza AE, Reslan OM, Adler GK, Williams GH, Khalil RA. Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice. J Pharmacol Exp Ther. 2014 Feb; 348(2):260-70. PMID: 24281385.
    Citations: 18     Fields:    Translation:AnimalsCells
  59. Khalil RA. Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease. Biochem Pharmacol. 2013 Dec 15; 86(12):1627-42. PMID: 24099797.
    Citations: 39     Fields:    Translation:Humans
  60. Dang Y, Li W, Tran V, Khalil RA. EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone. Biochem Pharmacol. 2013 Sep 15; 86(6):734-47. PMID: 23856290.
    Citations: 27     Fields:    Translation:Animals
  61. Reslan OM, Yin Z, do Nascimento GR, Khalil RA. Subtype-specific estrogen receptor-mediated vasodilator activity in the cephalic, thoracic, and abdominal vasculature of female rat. J Cardiovasc Pharmacol. 2013 Jul; 62(1):26-40. PMID: 23429596.
    Citations: 24     Fields:    Translation:AnimalsCells
  62. Mazzuca MQ, Dang Y, Khalil RA. Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca²?]i in mesenteric microvessels of pregnant rats. Br J Pharmacol. 2013 Jul; 169(6):1335-51. PMID: 23646960.
    Citations: 18     Fields:    Translation:AnimalsCells
  63. Khalil RA. Novel therapies and botanical and mechanical approaches for management of cardiovascular disease. Recent Pat Cardiovasc Drug Discov. 2013 Apr; 8(1):1. PMID: 23721364.
    Citations:    Fields:    Translation:HumansAnimals
  64. Kucukguven A, Khalil RA. Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. Curr Drug Targets. 2013 Mar; 14(3):287-324. PMID: 23316963.
    Citations: 38     Fields:    Translation:Humans
  65. Khalil RA. Protein Kinase C Inhibitors as Modulators of Vascular Function and their Application in Vascular Disease. Pharmaceuticals (Basel). 2013; 6(3):407-39. PMID: 23580870.
    Citations: 12     
  66. Anwar MA, Vorkas P, Li J, Resslan O, Want E, Raffetto JD, Khalil RA, Holmes E, Davies AH. Prolonged Mechanical Stretch Alters the Metabolic Profile in Rat Inferior Vena Cava. J Vasc Surg Venous Lymphat Disord. 2013 Jan; 1(1):105-6. PMID: 26993918.
    Citations:    Fields:    
  67. Majed BH, Khalil RA. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Pharmacol Rev. 2012 Jul; 64(3):540-82. PMID: 22679221.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  68. Yin Z, Sada AA, Reslan OM, Narula N, Khalil RA. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 01; 303(1):E55-70. PMID: 22496348.
    Citations: 26     Fields:    Translation:Animals
  69. Mazzuca MQ, Khalil RA. Vascular endothelin receptor type B: structure, function and dysregulation in vascular disease. Biochem Pharmacol. 2012 Jul 15; 84(2):147-62. PMID: 22484314.
    Citations: 53     Fields:    Translation:HumansCells
  70. Reslan OM, Khalil RA. Vascular effects of estrogenic menopausal hormone therapy. Rev Recent Clin Trials. 2012 Feb; 7(1):47-70. PMID: 21864249.
    Citations: 29     Fields:    Translation:HumansAnimals
  71. Gencel VB, Benjamin MM, Bahou SN, Khalil RA. Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease. Mini Rev Med Chem. 2012 Feb; 12(2):149-74. PMID: 22070687.
    Citations: 36     Fields:    Translation:HumansAnimals
  72. Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L875-90. PMID: 22287610.
    Citations: 11     Fields:    Translation:AnimalsCells
  73. Benjamin MM, Khalil RA. Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease. Exp Suppl. 2012; 103:209-79. PMID: 22642194.
    Citations: 58     Fields:    Translation:Humans
  74. Raffetto JD, Yu P, Reslan OM, Xia Y, Khalil RA. Endothelium-dependent nitric oxide and hyperpolarization-mediated venous relaxation pathways in rat inferior vena cava. J Vasc Surg. 2012 Jun; 55(6):1716-25. PMID: 22209615.
    Citations: 3     Fields:    Translation:AnimalsCells
  75. Khalil RA. Modulators of the vascular endothelin receptor in blood pressure regulation and hypertension. Curr Mol Pharmacol. 2011 Nov; 4(3):176-86. PMID: 21222646.
    Citations: 18     Fields:    Translation:HumansCells
  76. Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H1862-71. PMID: 21873498.
    Citations: 35     Fields:    Translation:AnimalsCells
  77. Bafford R, Sui XX, Park M, Miyahara T, Newfell BG, Jaffe IZ, Romero JR, Adler GK, Williams GH, Khalil RA, Conte MS. Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H41-7. PMID: 21536849.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  78. Raffetto JD, Khalil RA. Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins. J Vasc Surg. 2011 Aug; 54(2):489-96. PMID: 21498026.
    Citations: 12     Fields:    Translation:AnimalsCells
  79. Lim CS, Qiao X, Reslan OM, Xia Y, Raffetto JD, Paleolog E, Davies AH, Khalil RA. Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava. J Vasc Surg. 2011 Mar; 53(3):764-73. PMID: 21106323.
    Citations: 27     Fields:    Translation:AnimalsCells
  80. Christou HA, Khalil RA. Sex hormones and vascular protection in pulmonary arterial hypertension. J Cardiovasc Pharmacol. 2010 Nov; 56(5):471-4. PMID: 20881609.
    Citations: 5     Fields:    Translation:HumansAnimals
  81. Reslan OM, Khalil RA. Molecular and vascular targets in the pathogenesis and management of the hypertension associated with preeclampsia. Cardiovasc Hematol Agents Med Chem. 2010 Oct 01; 8(4):204-26. PMID: 20923405.
    Citations: 35     Fields:    Translation:HumansAnimals
  82. Masood DE, Roach EC, Beauregard KG, Khalil RA. Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease. Curr Drug Metab. 2010 Oct; 11(8):693-714. PMID: 21189141.
    Citations: 21     Fields:    Translation:HumansAnimals
  83. Ma Y, Qiao X, Falone AE, Reslan OM, Sheppard SJ, Khalil RA. Gender-specific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat. Cell Physiol Biochem. 2010; 26(3):457-70. PMID: 20798531.
    Citations: 24     Fields:    Translation:Animals
  84. Pojoga LH, Adamová Z, Kumar A, Stennett AK, Romero JR, Adler GK, Williams GH, Khalil RA. Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1776-88. PMID: 20363891.
    Citations: 22     Fields:    Translation:AnimalsCells
  85. Raffetto JD, Qiao X, Beauregard KG, Tanbe AF, Kumar A, Mam V, Khalil RA. Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veins. J Vasc Surg. 2010 Apr; 51(4):962-71. PMID: 20347695.
    Citations: 3     Fields:    Translation:HumansCells
  86. Raffetto JD, Qiao X, Beauregard KG, Khalil RA. Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg. 2010 Apr; 51(4):972-81. PMID: 20347696.
    Citations: 19     Fields:    Translation:AnimalsCells
  87. Tanbe AF, Khalil RA. Circulating and Vascular Bioactive Factors during Hypertension in Pregnancy. Curr Bioact Compd. 2010 Mar 01; 6(1):60-75. PMID: 20419111.
    Citations: 16     
  88. Sheppard SJ, Khalil RA. Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy. Cardiovasc Hematol Disord Drug Targets. 2010 Mar; 10(1):33-52. PMID: 20041838.
    Citations: 18     Fields:    Translation:Humans
  89. Khalil RA. Potential approaches to enhance the effects of estrogen on senescent blood vessels and postmenopausal cardiovascular disease. Cardiovasc Hematol Agents Med Chem. 2010 Jan; 8(1):29-46. PMID: 20210774.
    Citations: 5     Fields:    Translation:HumansAnimals
  90. Mam V, Tanbe AF, Vitali SH, Arons E, Christou HA, Khalil RA. Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats. J Pharmacol Exp Ther. 2010 Feb; 332(2):455-62. PMID: 19915069.
    Citations: 31     Fields:    Translation:Animals
  91. do Nascimento GR, Barros YV, Wells AK, Khalil RA. Research into Specific Modulators of Vascular Sex Hormone Receptors in the Management of Postmenopausal Cardiovascular Disease. Curr Hypertens Rev. 2009 Nov; 5(4):283-306. PMID: 20694192.
    Citations: 4     Fields:    
  92. Xia Y, Khalil RA. Sex-related decrease in [Ca2+]i signaling and Ca2+-dependent contraction in inferior vena cava of female rat. Am J Physiol Regul Integr Comp Physiol. 2010 Jan; 298(1):R15-24. PMID: 19864336.
    Citations: 5     Fields:    Translation:AnimalsCells
  93. Adamova Z, Ozkan S, Khalil RA. Vascular and cellular calcium in normal and hypertensive pregnancy. Curr Clin Pharmacol. 2009 Sep; 4(3):172-90. PMID: 19500073.
    Citations: 8     Fields:    Translation:HumansCells
  94. Sprague AH, Khalil RA. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol. 2009 Sep 15; 78(6):539-52. PMID: 19413999.
    Citations: 433     Fields:    Translation:Cells
  95. Ponnuchamy B, Khalil RA. Cellular mediators of renal vascular dysfunction in hypertension. Am J Physiol Regul Integr Comp Physiol. 2009 Apr; 296(4):R1001-18. PMID: 19225145.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  96. Stennett AK, Qiao X, Falone AE, Koledova VV, Khalil RA. Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H745-55. PMID: 19151255.
    Citations: 23     Fields:    Translation:AnimalsCells
  97. Smiley DA, Khalil RA. Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels. Curr Med Chem. 2009; 16(15):1863-87. PMID: 19442151.
    Citations: 29     Fields:    Translation:HumansCells
  98. Ross RL, Serock MR, Khalil RA. Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease. Curr Cardiol Rev. 2008 Nov; 4(4):309-22. PMID: 20066139.
    Citations: 12     Fields:    
  99. Serock MR, Wells AK, Khalil RA. Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov; 3(3):165-86. PMID: 18991792.
    Citations: 9     Fields:    Translation:Humans
  100. Raffetto JD, Barros YV, Wells AK, Khalil RA. MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides. J Surg Res. 2010 Apr; 159(2):755-64. PMID: 19482300.
    Citations: 26     Fields:    Translation:HumansAnimals
  101. Chen W, Khalil RA. Differential [Ca2+]i signaling of vasoconstriction in mesenteric microvessels of normal and reduced uterine perfusion pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2008 Dec; 295(6):R1962-72. PMID: 18843089; PMCID: PMC2685295.
    Citations: 14     Fields:    Translation:AnimalsCells
  102. Raffetto JD, Khalil RA. Matrix metalloproteinases in venous tissue remodeling and varicose vein formation. Curr Vasc Pharmacol. 2008 Jul; 6(3):158-72. PMID: 18673156.
    Citations: 19     Fields:    Translation:HumansAnimals
  103. Ponnuchamy B, Khalil RA. Role of ADAMs in endothelial cell permeability: cadherin shedding and leukocyte rolling. Circ Res. 2008 May 23; 102(10):1139-42. PMID: 18497310.
    Citations: 14     Fields:    Translation:HumansCells
  104. Raffetto JD, Qiao X, Koledova VV, Khalil RA. Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins. J Vasc Surg. 2008 Aug; 48(2):447-56. PMID: 18502086.
    Citations: 35     Fields:    Translation:Animals
  105. Pojoga LH, Yao TM, Sinha S, Ross RL, Lin JC, Raffetto JD, Adler GK, Williams GH, Khalil RA. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1258-65. PMID: 18178722; PMCID: PMC2268616.
    Citations: 27     Fields:    Translation:AnimalsCells
  106. Qiao X, McConnell KR, Khalil RA. Sex steroids and vascular responses in hypertension and aging. Gend Med. 2008; 5 Suppl A:S46-64. PMID: 18395683.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  107. Raffetto JD, Khalil RA. Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology. 2008; 23(2):85-98. PMID: 18453484.
    Citations: 49     Fields:    Translation:HumansAnimals
  108. Raffetto JD, Khalil RA. Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem Pharmacol. 2008 Jan 15; 75(2):346-59. PMID: 17678629; PMCID: PMC2254136.
    Citations: 264     Fields:    Translation:HumansAnimals
  109. Koledova VV, Khalil RA. Sex hormone replacement therapy and modulation of vascular function in cardiovascular disease. Expert Rev Cardiovasc Ther. 2007 Jul; 5(4):777-89. PMID: 17605655.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  110. Claro S, Kanashiro CA, Oshiro ME, Ferreira AT, Khalil RA. alpha- and epsilon-protein kinase C activity during smooth muscle cell apoptosis in response to gamma-radiation. J Pharmacol Exp Ther. 2007 Sep; 322(3):964-72. PMID: 17600140.
    Citations: 4     Fields:    Translation:AnimalsCells
  111. Khalil RA. Sex hormones, vascular function and the outcome of hormone replacement therapy in cardiovascular disease. Future Cardiol. 2007 May; 3(3):283-300. PMID: 19804220.
    Citations:    Fields:    
  112. Raffetto JD, Ross RL, Khalil RA. Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation. J Vasc Surg. 2007 Feb; 45(2):373-80. PMID: 17264019; PMCID: PMC1794684.
    Citations: 49     Fields:    Translation:Animals
  113. Koledova VV, Khalil RA. Ca2+, calmodulin, and cyclins in vascular smooth muscle cell cycle. Circ Res. 2006 May 26; 98(10):1240-3. PMID: 16728669; PMCID: PMC1474836.
    Citations: 9     Fields:    Translation:HumansAnimals
  114. Stennett AK, Khalil RA. Neurovascular mechanisms of hypertension in pregnancy. Curr Neurovasc Res. 2006 May; 3(2):131-48. PMID: 16719796.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  115. Khalil RA. Dietary salt and hypertension: new molecular targets add more spice. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R509-13. PMID: 16467497.
    Citations: 12     Fields:    Translation:HumansAnimals
  116. Hynynen MM, Khalil RA. The vascular endothelin system in hypertension--recent patents and discoveries. Recent Pat Cardiovasc Drug Discov. 2006 Jan; 1(1):95-108. PMID: 17200683.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  117. Salamanca DA, Khalil RA. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol. 2005 Nov 25; 70(11):1537-47. PMID: 16139252; PMCID: PMC1343531.
    Citations: 71     Fields:    Translation:HumansAnimals
  118. Khalil RA. Sex hormones as potential modulators of vascular function in hypertension. Hypertension. 2005 Aug; 46(2):249-54. PMID: 15983238.
    Citations: 42     Fields:    Translation:HumansAnimals
  119. Chew DK, Conte MS, Khalil RA. Matrix metalloproteinase-specific inhibition of Ca2+ entry mechanisms of vascular contraction. J Vasc Surg. 2004 Nov; 40(5):1001-10. PMID: 15557917.
    Citations: 46     Fields:    Translation:Animals
  120. Orshal JM, Khalil RA. Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2004 Jun; 286(6):R1013-23. PMID: 15142856.
    Citations: 20     Fields:    Translation:Animals
  121. Chew DK, Orshal JM, Khalil RA. Elastase promotes aortic dilation by inhibiting Ca2+ influx into vascular smooth muscle. J Cardiovasc Pharmacol. 2004 Apr; 43(4):504-13. PMID: 15085061.
    Citations: 6     Fields:    Translation:Animals
  122. McNair LL, Salamanca DA, Khalil RA. Endothelin-1 promotes Ca2+ antagonist-insensitive coronary smooth muscle contraction via activation of epsilon-protein kinase C. Hypertension. 2004 Apr; 43(4):897-904. PMID: 14981072.
    Citations: 20     Fields:    Translation:AnimalsCells
  123. Orshal JM, Khalil RA. Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol. 2004 Feb; 286(2):R233-49. PMID: 14707008.
    Citations: 185     Fields:    Translation:HumansAnimals
  124. Orshal JM, Khalil RA. Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension. 2004 Feb; 43(2):434-44. PMID: 14707155.
    Citations: 35     Fields:    Translation:Animals
  125. Payne JA, Alexander BT, Khalil RA. Decreased endothelium-dependent NO-cGMP vascular relaxation and hypertension in growth-restricted rats on a high-salt diet. Hypertension. 2004 Feb; 43(2):420-7. PMID: 14707161.
    Citations: 11     Fields:    Translation:Animals
  126. Wynne FL, Payne JA, Cain AE, Reckelhoff JF, Khalil RA. Age-related reduction in estrogen receptor-mediated mechanisms of vascular relaxation in female spontaneously hypertensive rats. Hypertension. 2004 Feb; 43(2):405-12. PMID: 14699001.
    Citations: 25     Fields:    Translation:Animals
  127. Dallas A, Khalil RA. Ca2+ antagonist-insensitive coronary smooth muscle contraction involves activation of epsilon-protein kinase C-dependent pathway. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1454-63. PMID: 14600078.
    Citations: 9     Fields:    Translation:AnimalsCells
  128. Chew DK, Orshal JM, Khalil RA. Elastase-induced suppression of endothelin-mediated Ca2+ entry mechanisms of vascular contraction. Hypertension. 2003 Oct; 42(4):818-24. PMID: 12900430.
    Citations: 6     Fields:    Translation:Animals
  129. Payne JA, Alexander BT, Khalil RA. Reduced endothelial vascular relaxation in growth-restricted offspring of pregnant rats with reduced uterine perfusion. Hypertension. 2003 Oct; 42(4):768-74. PMID: 12874089.
    Citations: 29     Fields:    Translation:Animals
  130. Payne JA, Reckelhoff JF, Khalil RA. Role of oxidative stress in age-related reduction of NO-cGMP-mediated vascular relaxation in SHR. Am J Physiol Regul Integr Comp Physiol. 2003 Sep; 285(3):R542-51. PMID: 12816742.
    Citations: 15     Fields:    Translation:Animals
  131. Wynne FL, Khalil RA. Testosterone and coronary vascular tone: implications in coronary artery disease. J Endocrinol Invest. 2003 Feb; 26(2):181-6. PMID: 12739749.
    Citations: 11     Fields:    Translation:HumansCells
  132. Thompson J, Khalil RA. Gender differences in the regulation of vascular tone. Clin Exp Pharmacol Physiol. 2003 Jan-Feb; 30(1-2):1-15. PMID: 12542447.
    Citations: 38     Fields:    Translation:Humans
  133. Smith L, Payne JA, Sedeek MH, Granger JP, Khalil RA. Endothelin-induced increases in Ca2+ entry mechanisms of vascular contraction are enhanced during high-salt diet. Hypertension. 2003 Mar; 41(3 Pt 2):787-93. PMID: 12623997.
    Citations: 17     Fields:    Translation:Animals
  134. Tian N, Gannon AW, Khalil RA, Manning RD. Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol. 2003 Feb; 284(2):R372-9. PMID: 12399250.
    Citations: 4     Fields:    Translation:Animals
  135. Murphy JG, Herrington JN, Granger JP, Khalil RA. Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H393-403. PMID: 12388289.
    Citations: 23     Fields:    Translation:AnimalsCells
  136. Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation. 2002 Jul; 9(3):147-60. PMID: 12080413.
    Citations: 109     Fields:    Translation:Humans
  137. Giardina JB, Green GM, Cockrell KL, Granger JP, Khalil RA. TNF-alpha enhances contraction and inhibits endothelial NO-cGMP relaxation in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2002 Jul; 283(1):R130-43. PMID: 12069938.
    Citations: 19     Fields:    Translation:Animals
  138. Khalil RA, Granger JP. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. Am J Physiol Regul Integr Comp Physiol. 2002 Jul; 283(1):R29-45. PMID: 12069928.
    Citations: 66     Fields:    Translation:Animals
  139. Coleman DA, Khalil RA. Physiologic increases in extracellular sodium salt enhance coronary vasoconstriction and Ca2+ entry. J Cardiovasc Pharmacol. 2002 Jul; 40(1):58-66. PMID: 12072578.
    Citations: 1     Fields:    Translation:AnimalsCells
  140. Barron LA, Green GM, Khalil RA. Gender differences in vascular smooth muscle reactivity to increases in extracellular sodium salt. Hypertension. 2002 Feb; 39(2 Pt 2):425-32. PMID: 11882584.
    Citations: 8     Fields:    Translation:Animals
  141. Giardina JB, Cockrell KL, Granger JP, Khalil RA. Low-salt diet enhances vascular reactivity and Ca(2+) entry in pregnant rats with normal and reduced uterine perfusion pressure. Hypertension. 2002 Feb; 39(2 Pt 2):368-74. PMID: 11882575.
    Citations: 6     Fields:    Translation:Animals
  142. Cain AE, Tanner DM, Khalil RA. Endothelin-1--induced enhancement of coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)](i) sensitization pathways. Hypertension. 2002 Feb; 39(2 Pt 2):543-9. PMID: 11882605.
    Citations: 23     Fields:    Translation:AnimalsCells
  143. Davis JR, Giardina JB, Green GM, Alexander BT, Granger JP, Khalil RA. Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2002 Feb; 282(2):R390-9. PMID: 11792648.
    Citations: 30     Fields:    Translation:Animals
  144. Alexander BT, Bennett WA, Khalil RA, Granger JP. Preeclampsia: linking placental ischemia with cardiovascular-renal dysfunction. News Physiol Sci. 2001 Dec; 16:282-6. PMID: 11719606.
    Citations: 11     Fields:    Translation:Humans
  145. Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction. Hypertension. 2001 Sep; 38(3 Pt 2):718-22. PMID: 11566964.
    Citations: 100     Fields:    Translation:Humans
  146. Barron LA, Giardina JB, Granger JP, Khalil RA. High-salt diet enhances vascular reactivity in pregnant rats with normal and reduced uterine perfusion pressure. Hypertension. 2001 Sep; 38(3 Pt 2):730-5. PMID: 11566966.
    Citations: 12     Fields:    Translation:Animals
  147. Granger JP, Alexander BT, Bennett WA, Khalil RA. Pathophysiology of pregnancy-induced hypertension. Am J Hypertens. 2001 Jun; 14(6 Pt 2):178S-185S. PMID: 11411754.
    Citations: 44     Fields:    Translation:Humans
  148. Giardina JB, Green GM, Rinewalt AN, Granger JP, Khalil RA. Role of endothelin B receptors in enhancing endothelium-dependent nitric oxide-mediated vascular relaxation during high salt diet. Hypertension. 2001 Feb; 37(2 Pt 2):516-23. PMID: 11230328.
    Citations: 18     Fields:    Translation:Animals
  149. Sirous ZN, Fleming JB, Khalil RA. Endothelin-1 enhances eicosanoids-induced coronary smooth muscle contraction by activating specific protein kinase C isoforms. Hypertension. 2001 Feb; 37(2 Pt 2):497-504. PMID: 11230325.
    Citations: 10     Fields:    Translation:AnimalsCells
  150. Giardina JB, Tanner DJ, Khalil RA. Oxidized-LDL enhances coronary vasoconstriction by increasing the activity of protein kinase C isoforms alpha and epsilon. Hypertension. 2001 Feb; 37(2 Pt 2):561-8. PMID: 11230335.
    Citations: 8     Fields:    Translation:AnimalsCells
  151. Kanashiro CA, Khalil RA. Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C34-45. PMID: 11121374.
    Citations: 39     Fields:    Translation:Animals
  152. Murphy JG, Fleming JB, Cockrell KL, Granger JP, Khalil RA. [Ca(2+)](i) signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS. Am J Physiol Regul Integr Comp Physiol. 2001 Jan; 280(1):R87-99. PMID: 11124138.
    Citations: 16     Fields:    Translation:AnimalsCells
  153. Murphy JG, Khalil RA. Gender-specific reduction in contractility and [Ca(2+)](i) in vascular smooth muscle cells of female rat. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C834-44. PMID: 10751331.
    Citations: 36     Fields:    Translation:AnimalsCells
  154. Kanashiro CA, Altirkawi KA, Khalil RA. Preconditioning of coronary artery against vasoconstriction by endothelin-1 and prostaglandin F2alpha during repeated downregulation of epsilon-protein kinase C. J Cardiovasc Pharmacol. 2000 Mar; 35(3):491-501. PMID: 10710137.
    Citations: 8     Fields:    Translation:AnimalsCells
  155. Kanashiro CA, Cockrell KL, Alexander BT, Granger JP, Khalil RA. Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesis. Am J Physiol Regul Integr Comp Physiol. 2000 Feb; 278(2):R295-303. PMID: 10666128.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  156. Crews JK, Herrington JN, Granger JP, Khalil RA. Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat. Hypertension. 2000 Jan; 35(1 Pt 2):367-72. PMID: 10642326.
    Citations: 76     Fields:    Translation:Animals
  157. Khalil RA, Crews JK, Carroll JF, Hall JE. Enhanced vascular reactivity and Ca2+ entry with low-salt diet: effect of obesity. Hypertension. 1999 Oct; 34(4 Pt 2):882-8. PMID: 10523378.
    Citations: 2     Fields:    Translation:Animals
  158. Kanashiro CA, Alexander BT, Granger JP, Khalil RA. Ca(2+)-insensitive vascular protein kinase C during pregnancy and NOS inhibition. Hypertension. 1999 Oct; 34(4 Pt 2):924-30. PMID: 10523386.
    Citations: 12     Fields:    Translation:Animals
  159. Crews JK, Murphy JG, Khalil RA. Gender differences in Ca(2+) entry mechanisms of vasoconstriction in Wistar-Kyoto and spontaneously hypertensive rats. Hypertension. 1999 Oct; 34(4 Pt 2):931-6. PMID: 10523387.
    Citations: 21     Fields:    Translation:Animals
  160. Murphy JG, Khalil RA. Decreased [Ca(2+)](i) during inhibition of coronary smooth muscle contraction by 17beta-estradiol, progesterone, and testosterone. J Pharmacol Exp Ther. 1999 Oct; 291(1):44-52. PMID: 10490885.
    Citations: 42     Fields:    Translation:Animals
  161. Crews JK, Khalil RA. Gender-specific inhibition of Ca2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin Exp Pharmacol Physiol. 1999 Sep; 26(9):707-15. PMID: 10499160.
    Citations: 46     Fields:    Translation:Animals
  162. Crews JK, Khalil RA. Antagonistic effects of 17 beta-estradiol, progesterone, and testosterone on Ca2+ entry mechanisms of coronary vasoconstriction. Arterioscler Thromb Vasc Biol. 1999 Apr; 19(4):1034-40. PMID: 10195933.
    Citations: 56     Fields:    Translation:AnimalsCells
  163. Crews JK, Novak J, Granger JP, Khalil RA. Stimulated mechanisms of Ca2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats. Am J Physiol. 1999 02; 276(2):R530-8. PMID: 9950934.
    Citations: 13     Fields:    Translation:Animals
  164. Kanashiro CA, Khalil RA. Signal transduction by protein kinase C in mammalian cells. Clin Exp Pharmacol Physiol. 1998 Dec; 25(12):974-85. PMID: 9887993.
    Citations: 27     Fields:    Translation:AnimalsCells
  165. Kanashiro CA, Khalil RA. Isoform-specific protein kinase C activity at variable Ca2+ entry during coronary artery contraction by vasoactive eicosanoids. Can J Physiol Pharmacol. 1998 Dec; 76(12):1110-9. PMID: 10326833.
    Citations: 1     Fields:    Translation:AnimalsCells
  166. Khalil RA, Crews JK, Novak J, Kassab S, Granger JP. Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats. Hypertension. 1998 May; 31(5):1065-9. PMID: 9576115.
    Citations: 40     Fields:    Translation:Animals
  167. Mii S, Khalil RA, Morgan KG, Ware JA, Kent KC. Mitogen-activated protein kinase and proliferation of human vascular smooth muscle cells. Am J Physiol. 1996 Jan; 270(1 Pt 2):H142-50. PMID: 8769745.
    Citations: 16     Fields:    Translation:HumansCells
  168. Khalil RA, Menice CB, Wang CL, Morgan KG. Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells. Circ Res. 1995 Jun; 76(6):1101-8. PMID: 7538916.
    Citations: 24     Fields:    Translation:AnimalsCells
  169. Khalil RA, Lajoie C, Morgan KG. In situ determination of [Ca2+]i threshold for translocation of the alpha-protein kinase C isoform. Am J Physiol. 1994 Jun; 266(6 Pt 1):C1544-51. PMID: 8023886.
    Citations: 21     Fields:    Translation:AnimalsCells
  170. Khalil RA, Morgan KG. PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation. Am J Physiol. 1993 Aug; 265(2 Pt 1):C406-11. PMID: 8368270.
    Citations: 25     Fields:    Translation:AnimalsCells
  171. Khalil RA, Morgan KG. Phenylephrine-induced translocation of protein kinase C and shortening of two types of vascular cells of the ferret. J Physiol. 1992 Sep; 455:585-99. PMID: 1484363; PMCID: PMC1175660.
    Citations: 13     Fields:    Translation:AnimalsCells
  172. Khalil RA, Lajoie C, Resnick MS, Morgan KG. Ca(2+)-independent isoforms of protein kinase C differentially translocate in smooth muscle. Am J Physiol. 1992 Sep; 263(3 Pt 1):C714-9. PMID: 1415520.
    Citations: 42     Fields:    Translation:Animals
  173. Morgan KG, Khalil RA, Suematsu E, Katsuyama H. Calcium-dependent and calcium-independent pathways of signal transduction in smooth muscle. Jpn J Pharmacol. 1992; 58 Suppl 2:47P-53P. PMID: 1507643.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  174. Khalil RA, Morgan KG. Imaging of protein kinase C distribution and translocation in living vascular smooth muscle cells. Circ Res. 1991 Dec; 69(6):1626-31. PMID: 1954682.
    Citations: 10     Fields:    Translation:AnimalsCells
  175. Khalil RA, van Breemen C. Intracellular free calcium concentration/force relationship in rabbit inferior vena cava activated by norepinephrine and high K+. Pflugers Arch. 1990 Aug; 416(6):727-34. PMID: 2247344.
    Citations: 15     Fields:    Translation:Animals
  176. Nishimura J, Khalil RA, Drenth JP, van Breemen C. Evidence for increased myofilament Ca2+ sensitivity in norepinephrine-activated vascular smooth muscle. Am J Physiol. 1990 Jul; 259(1 Pt 2):H2-8. PMID: 2115742.
    Citations: 17     Fields:    Translation:AnimalsCells
  177. Nishimura J, Khalil RA, van Breemen C. Agonist-induced vascular tone. Hypertension. 1989 Jun; 13(6 Pt 2):835-44. PMID: 2544524.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  178. Khalil RA, van Breemen C. Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation? J Pharmacol Exp Ther. 1988 Feb; 244(2):537-42. PMID: 3346836.
    Citations: 32     Fields:    Translation:AnimalsCells
  179. Khalil R, Lodge N, Saida K, van Breemen C. Mechanism of calcium activation in vascular smooth muscle. J Hypertens Suppl. 1987 Dec; 5(4):S5-15. PMID: 2450186.
    Citations: 10     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.