Harvard Catalyst Profiles

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Raouf A. Khalil, Ph.D., M.D.

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Mentoring
Available: 10/16/19, Expires: 10/15/20

To assist in performing experiments, acquiring and analyzing data in a cardiovascular research laboratory. Trainee will have the opportunity to interact with established cardiovascular surgeons, scientists, research fellows and graduate and undergraduate students. The trainee will work on projects involving understanding the vascular mechanisms of hypertension and coronary artery disease, with emphasis on vascular disease in women such as preeclampsia and postmenopausal hypertension, and inflammatory vascular disease such as varicose veins and abdominal aortic aneurysm. The trainee will use state-of-the-art techniques in physiology, imaging microscopy, biochemistry and molecular biology to measure vital parameters as well as the expression/amount/activity of vascular signaling molecules in discarded human vessels and in animal models of vascular diseases, isolated blood vessels and microvessels, and cultured vascular cells. This is an unpaid opportunity.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56HL147889 (KHALIL, RAOUF A) Sep 20, 2019 - Aug 31, 2020
    NIH/NHLBI
    Vascular Mechanisms of Hypertension-in-Pregnancy
    Role: Principal Investigator
  2. R21HL111775 (KHALIL, RAOUF A) Feb 1, 2013 - Jan 31, 2015
    NIH/NHLBI
    Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous Insufficiency
    Role: Principal Investigator
  3. R21HL098724 (KHALIL, RAOUF A) Aug 6, 2010 - Apr 30, 2014
    NIH/NHLBI
    Role of Endothelin B Receptor in Vascular Protection in Females
    Role: Principal Investigator
  4. R03HD060702 (KHALIL, RAOUF A) May 8, 2009 - Apr 30, 2012
    NIH/NICHD
    Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
    Role: Principal Investigator
  5. R01HL070659 (KHALIL, RAOUF A.) Jul 1, 2003 - Jun 30, 2009
    NIH/NHLBI
    Vascular Protective Role of Endothelin B Receptors
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Raffetto JD, Yu W, Wang X, Calanni F, Mattana P, Khalil RA. Sulodexide Improves Contraction and Decreases Matrix Metalloproteinase-2 and -9 in Veins Under Prolonged Stretch. J Cardiovasc Pharmacol. 2020 Mar; 75(3):211-221. PMID: 31738197.
    Citations:    
  2. Lin C, He H, Cui N, Ren Z, Zhu M, Khalil RA. Decreased uterine vascularization and uterine arterial expansive remodeling with reduced matrix metalloproteinase-2 and -9 in hypertensive pregnancy. Am J Physiol Heart Circ Physiol. 2020 Jan 01; 318(1):H165-H180. PMID: 31834839.
    Citations:    
  3. Raffetto JD, Calanni F, Mattana P, Khalil RA. Sulodexide promotes arterial relaxation via endothelium-dependent nitric oxide-mediated pathway. Biochem Pharmacol. 2019 08; 166:347-356. PMID: 31014752.
    Citations:    
  4. Zhong S, Khalil RA. A Disintegrin and Metalloproteinase (ADAM) and ADAM with thrombospondin motifs (ADAMTS) family in vascular biology and disease. Biochem Pharmacol. 2019 06; 164:188-204. PMID: 30905657.
    Citations:    
  5. Yu W, Gao W, Rong D, Wu Z, Khalil RA. Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia. Microcirculation. 2018 Oct 19; e12508. PMID: 30338879.
    Citations:    Fields:    
  6. Ren Z, Cui N, Zhu M, Khalil RA. Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in hypertensive pregnancy. Am J Physiol Heart Circ Physiol. 2018 07 01; 315(1):H33-H47. PMID: 29569955.
    Citations:    Fields:    
  7. Yin Z, He W, Li Y, Li D, Li H, Yang Y, Wei Z, Shen B, Wang X, Cao Y, Khalil RA. Adaptive reduction of human myometrium contractile activity in response to prolonged uterine stretch during term and twin pregnancy. Role of TREK-1 channel. Biochem Pharmacol. 2018 06; 152:252-263. PMID: 29577872.
    Citations:    Fields:    
  8. Liu Z, Khalil RA. Evolving mechanisms of vascular smooth muscle contraction highlight key targets in vascular disease. Biochem Pharmacol. 2018 07; 153:91-122. PMID: 29452094.
    Citations:    Fields:    
  9. Khalil RA. Preface. Adv Pharmacol. 2018; 81:xi-xii. PMID: 29310806.
    Citations:    Fields:    
  10. Yin Z, Li Y, He W, Li D, Li H, Yang Y, Shen B, Wang X, Cao Y, Khalil RA. Progesterone inhibits contraction and increases TREK-1 potassium channel expression in late pregnant rat uterus. Oncotarget. 2018 Jan 02; 9(1):651-661. PMID: 29416642.
    Citations:    Fields:    
  11. Christou H, Hudalla H, Michael Z, Filatava EJ, Li J, Zhu M, Possomato-Vieira JS, Dias-Junior C, Kourembanas S, Khalil RA. Impaired Pulmonary Arterial Vasoconstriction and Nitric Oxide-Mediated Relaxation Underlie Severe Pulmonary Hypertension in the Sugen-Hypoxia Rat Model. J Pharmacol Exp Ther. 2018 02; 364(2):258-274. PMID: 29212831.
    Citations:    Fields:    
  12. Liu J, Jia X, Jia S, Qin X, Zhang T, Liu L, Li H, Rong D, Zhou Z, Song Y, Zuo S, Duan C, Wu Z, Wei R, Ge Y, Wang X, Kong W, Xu X, Khalil RA, Huo Y, Guo W. Small infrarenal aortic diameter associated with lower-extremity peripheral artery disease in Chinese hypertensive adults. Sci Rep. 2017 11 06; 7(1):14547. PMID: 29109408.
    Citations:    Fields:    
  13. Wang X, Khalil RA. Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease. Adv Pharmacol. 2018; 81:241-330. PMID: 29310800.
    Citations:    Fields:    
  14. Dias-Junior CA, Chen J, Cui N, Chiang CL, Zhu M, Ren Z, Possomato-Vieira JS, Khalil RA. Angiogenic imbalance and diminished matrix metalloproteinase-2 and -9 underlie regional decreases in uteroplacental vascularization and feto-placental growth in hypertensive pregnancy. Biochem Pharmacol. 2017 12 15; 146:101-116. PMID: 28912068.
    Citations: 1     Fields:    Translation:Animals
  15. Li W, Cui N, Mazzuca MQ, Mata KM, Khalil RA. Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-a. Am J Physiol Heart Circ Physiol. 2017 Sep 01; 313(3):H491-H507. PMID: 28626073.
    Citations: 3     Fields:    Translation:AnimalsCells
  16. Chen J, Khalil RA. Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia. Prog Mol Biol Transl Sci. 2017; 148:87-165. PMID: 28662830.
    Citations: 3     Fields:    Translation:HumansAnimals
  17. Chen J, Ren Z, Zhu M, Khalil RA. Decreased homodimerization and increased TIMP-1 complexation of uteroplacental and uterine arterial matrix metalloproteinase-9 during hypertension-in-pregnancy. Biochem Pharmacol. 2017 08 15; 138:81-95. PMID: 28506758.
    Citations: 1     Fields:    Translation:AnimalsCells
  18. Liu J, Khalil RA. Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders. Prog Mol Biol Transl Sci. 2017; 148:355-420. PMID: 28662828.
    Citations: 4     Fields:    Translation:HumansAnimals
  19. Rong D, Liu J, Jia X, Al-Nafisee D, Jia S, Sun G, Li Y, Lu W, Li H, Zhang H, Ma X, Xiong J, Liu X, Khalil RA, Guo W. Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease in a Chinese Han population. Atherosclerosis. 2017 08; 263:205-210. PMID: 28651188.
    Citations: 3     Fields:    Translation:Humans
  20. Cui N, Hu M, Khalil RA. Biochemical and Biological Attributes of Matrix Metalloproteinases. Prog Mol Biol Transl Sci. 2017; 147:1-73. PMID: 28413025.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  21. Chen Y, Peng W, Raffetto JD, Khalil RA. Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease. Prog Mol Biol Transl Sci. 2017; 147:267-299. PMID: 28413031.
    Citations: 3     Fields:    Translation:HumansAnimals
  22. Khalil RA. Preface. Prog Mol Biol Transl Sci. 2017; 148:xi-xii. PMID: 28662831.
    Citations:    Fields:    Translation:HumansAnimals
  23. Khalil RA. Preface. Prog Mol Biol Transl Sci. 2017; 147:xi-xii. PMID: 28413033.
    Citations:    Fields:    Translation:HumansAnimals
  24. Ren Z, Chen J, Khalil RA. Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors. Methods Mol Biol. 2017; 1626:79-102. PMID: 28608202.
    Citations:    Fields:    Translation:HumansAnimalsCells
  25. Khalil RA. Preface. Adv Pharmacol. 2017; 78:xi-xii. PMID: 28212805.
    Citations:    Fields:    
  26. Anwar MA, Vorkas PA, Li J, Adesina-Georgiadis KN, Reslan OM, Raffetto JD, Want EJ, Khalil RA, Holmes E, Davies AH. Prolonged Mechanical Circumferential Stretch Induces Metabolic Changes in Rat Inferior Vena Cava. Eur J Vasc Endovasc Surg. 2016 Oct; 52(4):544-552. PMID: 27523725.
    Citations:    Fields:    Translation:Animals
  27. Ringvold HC, Khalil RA. Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders. Adv Pharmacol. 2017; 78:203-301. PMID: 28212798.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  28. Possomato-Vieira JS, Khalil RA. Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia. Adv Pharmacol. 2016; 77:361-431. PMID: 27451103.
    Citations: 6     Fields:    Translation:HumansAnimals
  29. Zhu M, Ren Z, Possomato-Vieira JS, Khalil RA. Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2016 09 01; 311(3):R505-21. PMID: 27280428.
    Citations: 7     Fields:    Translation:Animals
  30. Xia Y, Khalil RA. Pregnancy-associated adaptations in [Ca2+]i-dependent and Ca2+ sensitization mechanisms of venous contraction: implications in pregnancy-related venous disorders. Am J Physiol Heart Circ Physiol. 2016 06 01; 310(11):H1851-65. PMID: 27199130.
    Citations:    Fields:    Translation:Animals
  31. Khalil RA. Preface. Adv Pharmacol. 2016; 77:xiii-xiv. PMID: 27451104.
    Citations:    Fields:    
  32. Mata KM, Li W, Reslan OM, Siddiqui WT, Opsasnick LA, Khalil RA. Adaptive increases in expression and vasodilator activity of estrogen receptor subtypes in a blood vessel-specific pattern during pregnancy. Am J Physiol Heart Circ Physiol. 2015 Nov 15; 309(10):H1679-96. PMID: 26408543.
    Citations: 4     Fields:    Translation:Animals
  33. MacColl E, Khalil RA. Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease. J Pharmacol Exp Ther. 2015 Dec; 355(3):410-28. PMID: 26319699.
    Citations: 9     Fields:    Translation:HumansAnimals
  34. Ali SM, Khalil RA. Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy. Expert Opin Ther Targets. 2015; 19(11):1495-515. PMID: 26294111.
    Citations: 6     Fields:    Translation:HumansAnimals
  35. Pojoga LH, Yao TM, Opsasnick LA, Siddiqui WT, Reslan OM, Adler GK, Williams GH, Khalil RA. Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide-High Angiotensin II-Induced Cardiovascular Injury. J Pharmacol Exp Ther. 2015 Oct; 355(1):32-47. PMID: 26183312.
    Citations: 2     Fields:    Translation:AnimalsCells
  36. Garza AE, Pojoga LH, Moize B, Hafiz WM, Opsasnick LA, Siddiqui WT, Horenstein M, Adler GK, Williams GH, Khalil RA. Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake. Hypertension. 2015 Sep; 66(3):674-80. PMID: 26169051.
    Citations:    Fields:    Translation:Animals
  37. Shah DA, Khalil RA. Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia. Biochem Pharmacol. 2015 Jun 15; 95(4):211-26. PMID: 25916268.
    Citations: 21     Fields:    Translation:HumansAnimals
  38. Mazzuca MQ, Mata KM, Li W, Rangan SS, Khalil RA. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther. 2015 Feb; 352(2):291-304. PMID: 25472954.
    Citations: 4     Fields:    Translation:Animals
  39. Mazzuca MQ, Li W, Reslan OM, Yu P, Mata KM, Khalil RA. Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy. Hypertension. 2014 Sep; 64(3):632-43. PMID: 24914193.
    Citations: 17     Fields:    Translation:AnimalsCells
  40. Li W, Mata KM, Mazzuca MQ, Khalil RA. Altered matrix metalloproteinase-2 and -9 expression/activity links placental ischemia and anti-angiogenic sFlt-1 to uteroplacental and vascular remodeling and collagen deposition in hypertensive pregnancy. Biochem Pharmacol. 2014 Jun 01; 89(3):370-85. PMID: 24704473.
    Citations: 16     Fields:    Translation:Animals
  41. Ou M, Dang Y, Mazzuca MQ, Basile R, Khalil RA. Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol. 2014 Apr; 229(4):489-501. PMID: 24105843.
    Citations: 6     Fields:    Translation:AnimalsCells
  42. Khalil RA. Understanding basic muscle electrophysiology while keeping an eye on diseases of the heart, lung and blood. Recent Pat Cardiovasc Drug Discov. 2014; 9(1):1. PMID: 25600348.
    Citations:    Fields:    Translation:Humans
  43. Pojoga LH, Yao TM, Opsasnick LA, Garza AE, Reslan OM, Adler GK, Williams GH, Khalil RA. Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice. J Pharmacol Exp Ther. 2014 Feb; 348(2):260-70. PMID: 24281385.
    Citations: 12     Fields:    Translation:AnimalsCells
  44. Khalil RA. Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease. Biochem Pharmacol. 2013 Dec 15; 86(12):1627-42. PMID: 24099797.
    Citations: 17     Fields:    Translation:Humans
  45. Dang Y, Li W, Tran V, Khalil RA. EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone. Biochem Pharmacol. 2013 Sep 15; 86(6):734-47. PMID: 23856290.
    Citations: 10     Fields:    Translation:Animals
  46. Mazzuca MQ, Dang Y, Khalil RA. Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca²?]i in mesenteric microvessels of pregnant rats. Br J Pharmacol. 2013 Jul; 169(6):1335-51. PMID: 23646960.
    Citations: 12     Fields:    Translation:AnimalsCells
  47. Reslan OM, Yin Z, do Nascimento GR, Khalil RA. Subtype-specific estrogen receptor-mediated vasodilator activity in the cephalic, thoracic, and abdominal vasculature of female rat. J Cardiovasc Pharmacol. 2013 Jul; 62(1):26-40. PMID: 23429596.
    Citations: 15     Fields:    Translation:AnimalsCells
  48. Khalil RA. Novel therapies and botanical and mechanical approaches for management of cardiovascular disease. Recent Pat Cardiovasc Drug Discov. 2013 Apr; 8(1):1. PMID: 23721364.
    Citations:    Fields:    Translation:HumansAnimals
  49. Kucukguven A, Khalil RA. Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. Curr Drug Targets. 2013 Mar; 14(3):287-324. PMID: 23316963.
    Citations: 19     Fields:    Translation:Humans
  50. Khalil RA. Protein Kinase C Inhibitors as Modulators of Vascular Function and their Application in Vascular Disease. Pharmaceuticals (Basel). 2013; 6(3):407-39. PMID: 23580870.
    Citations: 7     
  51. Anwar MA, Vorkas P, Li J, Resslan O, Want E, Raffetto JD, Khalil RA, Holmes E, Davies AH. Prolonged Mechanical Stretch Alters the Metabolic Profile in Rat Inferior Vena Cava. J Vasc Surg Venous Lymphat Disord. 2013 Jan; 1(1):105-6. PMID: 26993918.
    Citations:    Fields:    
  52. Majed BH, Khalil RA. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Pharmacol Rev. 2012 Jul; 64(3):540-82. PMID: 22679221.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  53. Yin Z, Sada AA, Reslan OM, Narula N, Khalil RA. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 01; 303(1):E55-70. PMID: 22496348.
    Citations: 16     Fields:    Translation:Animals
  54. Mazzuca MQ, Khalil RA. Vascular endothelin receptor type B: structure, function and dysregulation in vascular disease. Biochem Pharmacol. 2012 Jul 15; 84(2):147-62. PMID: 22484314.
    Citations: 33     Fields:    Translation:HumansCells
  55. Reslan OM, Khalil RA. Vascular effects of estrogenic menopausal hormone therapy. Rev Recent Clin Trials. 2012 Feb; 7(1):47-70. PMID: 21864249.
    Citations: 12     Fields:    Translation:HumansAnimals
  56. Gencel VB, Benjamin MM, Bahou SN, Khalil RA. Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease. Mini Rev Med Chem. 2012 Feb; 12(2):149-74. PMID: 22070687.
    Citations: 19     Fields:    Translation:HumansAnimals
  57. Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L875-90. PMID: 22287610.
    Citations: 3     Fields:    Translation:AnimalsCells
  58. Benjamin MM, Khalil RA. Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease. Exp Suppl. 2012; 103:209-79. PMID: 22642194.
    Citations: 28     Translation:Humans
  59. Raffetto JD, Yu P, Reslan OM, Xia Y, Khalil RA. Endothelium-dependent nitric oxide and hyperpolarization-mediated venous relaxation pathways in rat inferior vena cava. J Vasc Surg. 2012 Jun; 55(6):1716-25. PMID: 22209615.
    Citations: 1     Fields:    Translation:AnimalsCells
  60. Khalil RA. Modulators of the vascular endothelin receptor in blood pressure regulation and hypertension. Curr Mol Pharmacol. 2011 Nov; 4(3):176-86. PMID: 21222646.
    Citations: 12     Fields:    Translation:HumansCells
  61. Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H1862-71. PMID: 21873498.
    Citations: 16     Fields:    Translation:AnimalsCells
  62. Bafford R, Sui XX, Park M, Miyahara T, Newfell BG, Jaffe IZ, Romero JR, Adler GK, Williams GH, Khalil RA, Conte MS. Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H41-7. PMID: 21536849.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  63. Raffetto JD, Khalil RA. Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins. J Vasc Surg. 2011 Aug; 54(2):489-96. PMID: 21498026.
    Citations: 8     Fields:    Translation:AnimalsCells
  64. Lim CS, Qiao X, Reslan OM, Xia Y, Raffetto JD, Paleolog E, Davies AH, Khalil RA. Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava. J Vasc Surg. 2011 Mar; 53(3):764-73. PMID: 21106323.
    Citations: 19     Fields:    Translation:AnimalsCells
  65. Christou HA, Khalil RA. Sex hormones and vascular protection in pulmonary arterial hypertension. J Cardiovasc Pharmacol. 2010 Nov; 56(5):471-4. PMID: 20881609.
    Citations: 3     Fields:    Translation:HumansAnimals
  66. Masood DE, Roach EC, Beauregard KG, Khalil RA. Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease. Curr Drug Metab. 2010 Oct; 11(8):693-714. PMID: 21189141.
    Citations: 15     Fields:    Translation:HumansAnimals
  67. Reslan OM, Khalil RA. Molecular and vascular targets in the pathogenesis and management of the hypertension associated with preeclampsia. Cardiovasc Hematol Agents Med Chem. 2010 Oct 01; 8(4):204-26. PMID: 20923405.
    Citations: 23     Fields:    Translation:HumansAnimals
  68. Ma Y, Qiao X, Falone AE, Reslan OM, Sheppard SJ, Khalil RA. Gender-specific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat. Cell Physiol Biochem. 2010; 26(3):457-70. PMID: 20798531.
    Citations: 18     Fields:    Translation:Animals
  69. Pojoga LH, Adamová Z, Kumar A, Stennett AK, Romero JR, Adler GK, Williams GH, Khalil RA. Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1776-88. PMID: 20363891.
    Citations: 17     Fields:    Translation:AnimalsCells
  70. Raffetto JD, Qiao X, Beauregard KG, Khalil RA. Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg. 2010 Apr; 51(4):972-81. PMID: 20347696.
    Citations: 13     Fields:    Translation:AnimalsCells
  71. Raffetto JD, Qiao X, Beauregard KG, Tanbe AF, Kumar A, Mam V, Khalil RA. Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veins. J Vasc Surg. 2010 Apr; 51(4):962-71. PMID: 20347695.
    Citations: 1     Fields:    Translation:HumansCells
  72. Sheppard SJ, Khalil RA. Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy. Cardiovasc Hematol Disord Drug Targets. 2010 Mar; 10(1):33-52. PMID: 20041838.
    Citations: 12     Fields:    Translation:Humans
  73. Tanbe AF, Khalil RA. Circulating and Vascular Bioactive Factors during Hypertension in Pregnancy. Curr Bioact Compd. 2010 Mar 01; 6(1):60-75. PMID: 20419111.
    Citations: 7     
  74. Khalil RA. Potential approaches to enhance the effects of estrogen on senescent blood vessels and postmenopausal cardiovascular disease. Cardiovasc Hematol Agents Med Chem. 2010 Jan; 8(1):29-46. PMID: 20210774.
    Citations: 3     Fields:    Translation:HumansAnimals
  75. Mam V, Tanbe AF, Vitali SH, Arons E, Christou HA, Khalil RA. Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats. J Pharmacol Exp Ther. 2010 Feb; 332(2):455-62. PMID: 19915069.
    Citations: 20     Fields:    Translation:Animals
  76. do Nascimento GR, Barros YV, Wells AK, Khalil RA. Research into Specific Modulators of Vascular Sex Hormone Receptors in the Management of Postmenopausal Cardiovascular Disease. Curr Hypertens Rev. 2009 Nov; 5(4):283-306. PMID: 20694192.
    Citations:    Fields:    
  77. Xia Y, Khalil RA. Sex-related decrease in [Ca2+]i signaling and Ca2+-dependent contraction in inferior vena cava of female rat. Am J Physiol Regul Integr Comp Physiol. 2010 Jan; 298(1):R15-24. PMID: 19864336.
    Citations: 4     Fields:    Translation:AnimalsCells
  78. Adamova Z, Ozkan S, Khalil RA. Vascular and cellular calcium in normal and hypertensive pregnancy. Curr Clin Pharmacol. 2009 Sep; 4(3):172-90. PMID: 19500073.
    Citations: 6     Fields:    Translation:HumansCells
  79. Sprague AH, Khalil RA. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol. 2009 Sep 15; 78(6):539-52. PMID: 19413999.
    Citations: 218     Fields:    Translation:Cells
  80. Ponnuchamy B, Khalil RA. Cellular mediators of renal vascular dysfunction in hypertension. Am J Physiol Regul Integr Comp Physiol. 2009 Apr; 296(4):R1001-18. PMID: 19225145.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  81. Stennett AK, Qiao X, Falone AE, Koledova VV, Khalil RA. Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H745-55. PMID: 19151255.
    Citations: 16     Fields:    Translation:AnimalsCells
  82. Smiley DA, Khalil RA. Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels. Curr Med Chem. 2009; 16(15):1863-87. PMID: 19442151.
    Citations: 21     Fields:    Translation:HumansCells
  83. Serock MR, Wells AK, Khalil RA. Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov; 3(3):165-86. PMID: 18991792.
    Citations: 9     Fields:    Translation:Humans
  84. Ross RL, Serock MR, Khalil RA. Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease. Curr Cardiol Rev. 2008 Nov; 4(4):309-22. PMID: 20066139.
    Citations: 9     Fields:    
  85. Raffetto JD, Barros YV, Wells AK, Khalil RA. MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides. J Surg Res. 2010 Apr; 159(2):755-64. PMID: 19482300.
    Citations: 15     Fields:    Translation:HumansAnimals
  86. Chen W, Khalil RA. Differential [Ca2+]i signaling of vasoconstriction in mesenteric microvessels of normal and reduced uterine perfusion pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2008 Dec; 295(6):R1962-72. PMID: 18843089.
    Citations: 9     Fields:    Translation:AnimalsCells
  87. Raffetto JD, Khalil RA. Matrix metalloproteinases in venous tissue remodeling and varicose vein formation. Curr Vasc Pharmacol. 2008 Jul; 6(3):158-72. PMID: 18673156.
    Citations: 12     Fields:    Translation:HumansAnimals
  88. Ponnuchamy B, Khalil RA. Role of ADAMs in endothelial cell permeability: cadherin shedding and leukocyte rolling. Circ Res. 2008 May 23; 102(10):1139-42. PMID: 18497310.
    Citations: 8     Fields:    Translation:HumansCells
  89. Raffetto JD, Qiao X, Koledova VV, Khalil RA. Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins. J Vasc Surg. 2008 Aug; 48(2):447-56. PMID: 18502086.
    Citations: 25     Fields:    Translation:Animals
  90. Pojoga LH, Yao TM, Sinha S, Ross RL, Lin JC, Raffetto JD, Adler GK, Williams GH, Khalil RA. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1258-65. PMID: 18178722.
    Citations: 22     Fields:    Translation:AnimalsCells
  91. Qiao X, McConnell KR, Khalil RA. Sex steroids and vascular responses in hypertension and aging. Gend Med. 2008; 5 Suppl A:S46-64. PMID: 18395683.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  92. Raffetto JD, Khalil RA. Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology. 2008; 23(2):85-98. PMID: 18453484.
    Citations: 35     Fields:    Translation:HumansAnimals
  93. Raffetto JD, Khalil RA. Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem Pharmacol. 2008 Jan 15; 75(2):346-59. PMID: 17678629.
    Citations: 179     Fields:    Translation:HumansAnimals
  94. Koledova VV, Khalil RA. Sex hormone replacement therapy and modulation of vascular function in cardiovascular disease. Expert Rev Cardiovasc Ther. 2007 Jul; 5(4):777-89. PMID: 17605655.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  95. Claro S, Kanashiro CA, Oshiro ME, Ferreira AT, Khalil RA. alpha- and epsilon-protein kinase C activity during smooth muscle cell apoptosis in response to gamma-radiation. J Pharmacol Exp Ther. 2007 Sep; 322(3):964-72. PMID: 17600140.
    Citations: 4     Fields:    Translation:AnimalsCells
  96. Khalil RA. Sex hormones, vascular function and the outcome of hormone replacement therapy in cardiovascular disease. Future Cardiol. 2007 May; 3(3):283-300. PMID: 19804220.
    Citations:    Fields:    
  97. Raffetto JD, Ross RL, Khalil RA. Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation. J Vasc Surg. 2007 Feb; 45(2):373-80. PMID: 17264019.
    Citations: 38     Fields:    Translation:Animals
  98. Koledova VV, Khalil RA. Ca2+, calmodulin, and cyclins in vascular smooth muscle cell cycle. Circ Res. 2006 May 26; 98(10):1240-3. PMID: 16728669.
    Citations: 5     Fields:    Translation:HumansAnimals
  99. Stennett AK, Khalil RA. Neurovascular mechanisms of hypertension in pregnancy. Curr Neurovasc Res. 2006 May; 3(2):131-48. PMID: 16719796.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  100. Khalil RA. Dietary salt and hypertension: new molecular targets add more spice. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R509-13. PMID: 16467497.
    Citations: 11     Fields:    Translation:HumansAnimals
  101. Hynynen MM, Khalil RA. The vascular endothelin system in hypertension--recent patents and discoveries. Recent Pat Cardiovasc Drug Discov. 2006 Jan; 1(1):95-108. PMID: 17200683.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  102. Salamanca DA, Khalil RA. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol. 2005 Nov 25; 70(11):1537-47. PMID: 16139252.
    Citations: 58     Fields:    Translation:HumansAnimals
  103. Khalil RA. Sex hormones as potential modulators of vascular function in hypertension. Hypertension. 2005 Aug; 46(2):249-54. PMID: 15983238.
    Citations: 33     Fields:    Translation:HumansAnimals
  104. Chew DK, Conte MS, Khalil RA. Matrix metalloproteinase-specific inhibition of Ca2+ entry mechanisms of vascular contraction. J Vasc Surg. 2004 Nov; 40(5):1001-10. PMID: 15557917.
    Citations: 35     Fields:    Translation:Animals
  105. Orshal JM, Khalil RA. Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2004 Jun; 286(6):R1013-23. PMID: 15142856.
    Citations: 13     Fields:    Translation:Animals
  106. Chew DK, Orshal JM, Khalil RA. Elastase promotes aortic dilation by inhibiting Ca2+ influx into vascular smooth muscle. J Cardiovasc Pharmacol. 2004 Apr; 43(4):504-13. PMID: 15085061.
    Citations: 3     Fields:    Translation:Animals
  107. McNair LL, Salamanca DA, Khalil RA. Endothelin-1 promotes Ca2+ antagonist-insensitive coronary smooth muscle contraction via activation of epsilon-protein kinase C. Hypertension. 2004 Apr; 43(4):897-904. PMID: 14981072.
    Citations: 17     Fields:    Translation:AnimalsCells
  108. Orshal JM, Khalil RA. Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol. 2004 Feb; 286(2):R233-49. PMID: 14707008.
    Citations: 132     Fields:    Translation:HumansAnimals
  109. Orshal JM, Khalil RA. Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension. 2004 Feb; 43(2):434-44. PMID: 14707155.
    Citations: 23     Fields:    Translation:Animals
  110. Payne JA, Alexander BT, Khalil RA. Decreased endothelium-dependent NO-cGMP vascular relaxation and hypertension in growth-restricted rats on a high-salt diet. Hypertension. 2004 Feb; 43(2):420-7. PMID: 14707161.
    Citations: 11     Fields:    Translation:Animals
  111. Wynne FL, Payne JA, Cain AE, Reckelhoff JF, Khalil RA. Age-related reduction in estrogen receptor-mediated mechanisms of vascular relaxation in female spontaneously hypertensive rats. Hypertension. 2004 Feb; 43(2):405-12. PMID: 14699001.
    Citations: 22     Fields:    Translation:Animals
  112. Dallas A, Khalil RA. Ca2+ antagonist-insensitive coronary smooth muscle contraction involves activation of epsilon-protein kinase C-dependent pathway. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1454-63. PMID: 14600078.
    Citations: 6     Fields:    Translation:AnimalsCells
  113. Chew DK, Orshal JM, Khalil RA. Elastase-induced suppression of endothelin-mediated Ca2+ entry mechanisms of vascular contraction. Hypertension. 2003 Oct; 42(4):818-24. PMID: 12900430.
    Citations: 4     Fields:    Translation:Animals
  114. Payne JA, Alexander BT, Khalil RA. Reduced endothelial vascular relaxation in growth-restricted offspring of pregnant rats with reduced uterine perfusion. Hypertension. 2003 Oct; 42(4):768-74. PMID: 12874089.
    Citations: 23     Fields:    Translation:Animals
  115. Payne JA, Reckelhoff JF, Khalil RA. Role of oxidative stress in age-related reduction of NO-cGMP-mediated vascular relaxation in SHR. Am J Physiol Regul Integr Comp Physiol. 2003 Sep; 285(3):R542-51. PMID: 12816742.
    Citations: 12     Fields:    Translation:Animals
  116. Wynne FL, Khalil RA. Testosterone and coronary vascular tone: implications in coronary artery disease. J Endocrinol Invest. 2003 Feb; 26(2):181-6. PMID: 12739749.
    Citations: 10     Fields:    Translation:HumansCells
  117. Thompson J, Khalil RA. Gender differences in the regulation of vascular tone. Clin Exp Pharmacol Physiol. 2003 Jan-Feb; 30(1-2):1-15. PMID: 12542447.
    Citations: 26     Fields:    Translation:Humans
  118. Smith L, Payne JA, Sedeek MH, Granger JP, Khalil RA. Endothelin-induced increases in Ca2+ entry mechanisms of vascular contraction are enhanced during high-salt diet. Hypertension. 2003 Mar; 41(3 Pt 2):787-93. PMID: 12623997.
    Citations: 15     Fields:    Translation:Animals
  119. Tian N, Gannon AW, Khalil RA, Manning RD. Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol. 2003 Feb; 284(2):R372-9. PMID: 12399250.
    Citations: 4     Fields:    Translation:Animals
  120. Murphy JG, Herrington JN, Granger JP, Khalil RA. Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H393-403. PMID: 12388289.
    Citations: 16     Fields:    Translation:AnimalsCells
  121. Giardina JB, Green GM, Cockrell KL, Granger JP, Khalil RA. TNF-alpha enhances contraction and inhibits endothelial NO-cGMP relaxation in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2002 Jul; 283(1):R130-43. PMID: 12069938.
    Citations: 15     Fields:    Translation:Animals
  122. Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation. 2002 Jul; 9(3):147-60. PMID: 12080413.
    Citations: 81     Fields:    Translation:Humans
  123. Coleman DA, Khalil RA. Physiologic increases in extracellular sodium salt enhance coronary vasoconstriction and Ca2+ entry. J Cardiovasc Pharmacol. 2002 Jul; 40(1):58-66. PMID: 12072578.
    Citations: 1     Fields:    Translation:AnimalsCells
  124. Khalil RA, Granger JP. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. Am J Physiol Regul Integr Comp Physiol. 2002 Jul; 283(1):R29-45. PMID: 12069928.
    Citations: 46     Fields:    Translation:Animals
  125. Giardina JB, Cockrell KL, Granger JP, Khalil RA. Low-salt diet enhances vascular reactivity and Ca(2+) entry in pregnant rats with normal and reduced uterine perfusion pressure. Hypertension. 2002 Feb; 39(2 Pt 2):368-74. PMID: 11882575.
    Citations: 4     Fields:    Translation:Animals
  126. Cain AE, Tanner DM, Khalil RA. Endothelin-1--induced enhancement of coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)](i) sensitization pathways. Hypertension. 2002 Feb; 39(2 Pt 2):543-9. PMID: 11882605.
    Citations: 21     Fields:    Translation:AnimalsCells
  127. Barron LA, Green GM, Khalil RA. Gender differences in vascular smooth muscle reactivity to increases in extracellular sodium salt. Hypertension. 2002 Feb; 39(2 Pt 2):425-32. PMID: 11882584.
    Citations: 6     Fields:    Translation:Animals
  128. Davis JR, Giardina JB, Green GM, Alexander BT, Granger JP, Khalil RA. Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2002 Feb; 282(2):R390-9. PMID: 11792648.
    Citations: 25     Fields:    Translation:Animals
  129. Alexander BT, Bennett WA, Khalil RA, Granger JP. Preeclampsia: linking placental ischemia with cardiovascular-renal dysfunction. News Physiol Sci. 2001 Dec; 16:282-6. PMID: 11719606.
    Citations: 8     Fields:    Translation:Humans
  130. Barron LA, Giardina JB, Granger JP, Khalil RA. High-salt diet enhances vascular reactivity in pregnant rats with normal and reduced uterine perfusion pressure. Hypertension. 2001 Sep; 38(3 Pt 2):730-5. PMID: 11566966.
    Citations: 9     Fields:    Translation:Animals
  131. Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction. Hypertension. 2001 Sep; 38(3 Pt 2):718-22. PMID: 11566964.
    Citations: 69     Fields:    Translation:Humans
  132. Granger JP, Alexander BT, Bennett WA, Khalil RA. Pathophysiology of pregnancy-induced hypertension. Am J Hypertens. 2001 Jun; 14(6 Pt 2):178S-185S. PMID: 11411754.
    Citations: 24     Fields:    Translation:Humans
  133. Giardina JB, Green GM, Rinewalt AN, Granger JP, Khalil RA. Role of endothelin B receptors in enhancing endothelium-dependent nitric oxide-mediated vascular relaxation during high salt diet. Hypertension. 2001 Feb; 37(2 Pt 2):516-23. PMID: 11230328.
    Citations: 17     Fields:    Translation:Animals
  134. Sirous ZN, Fleming JB, Khalil RA. Endothelin-1 enhances eicosanoids-induced coronary smooth muscle contraction by activating specific protein kinase C isoforms. Hypertension. 2001 Feb; 37(2 Pt 2):497-504. PMID: 11230325.
    Citations: 10     Fields:    Translation:AnimalsCells
  135. Giardina JB, Tanner DJ, Khalil RA. Oxidized-LDL enhances coronary vasoconstriction by increasing the activity of protein kinase C isoforms alpha and epsilon. Hypertension. 2001 Feb; 37(2 Pt 2):561-8. PMID: 11230335.
    Citations: 7     Fields:    Translation:AnimalsCells
  136. Kanashiro CA, Khalil RA. Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C34-45. PMID: 11121374.
    Citations: 34     Fields:    Translation:Animals
  137. Murphy JG, Fleming JB, Cockrell KL, Granger JP, Khalil RA. [Ca(2+)](i) signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS. Am J Physiol Regul Integr Comp Physiol. 2001 Jan; 280(1):R87-99. PMID: 11124138.
    Citations: 10     Fields:    Translation:AnimalsCells
  138. Murphy JG, Khalil RA. Gender-specific reduction in contractility and [Ca(2+)](i) in vascular smooth muscle cells of female rat. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C834-44. PMID: 10751331.
    Citations: 31     Fields:    Translation:AnimalsCells
  139. Kanashiro CA, Altirkawi KA, Khalil RA. Preconditioning of coronary artery against vasoconstriction by endothelin-1 and prostaglandin F2alpha during repeated downregulation of epsilon-protein kinase C. J Cardiovasc Pharmacol. 2000 Mar; 35(3):491-501. PMID: 10710137.
    Citations: 7     Fields:    Translation:AnimalsCells
  140. Kanashiro CA, Cockrell KL, Alexander BT, Granger JP, Khalil RA. Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesis. Am J Physiol Regul Integr Comp Physiol. 2000 Feb; 278(2):R295-303. PMID: 10666128.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  141. Crews JK, Herrington JN, Granger JP, Khalil RA. Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat. Hypertension. 2000 Jan; 35(1 Pt 2):367-72. PMID: 10642326.
    Citations: 49     Fields:    Translation:Animals
  142. Murphy JG, Khalil RA. Decreased [Ca(2+)](i) during inhibition of coronary smooth muscle contraction by 17beta-estradiol, progesterone, and testosterone. J Pharmacol Exp Ther. 1999 Oct; 291(1):44-52. PMID: 10490885.
    Citations: 35     Fields:    Translation:Animals
  143. Kanashiro CA, Alexander BT, Granger JP, Khalil RA. Ca(2+)-insensitive vascular protein kinase C during pregnancy and NOS inhibition. Hypertension. 1999 Oct; 34(4 Pt 2):924-30. PMID: 10523386.
    Citations: 11     Fields:    Translation:Animals
  144. Khalil RA, Crews JK, Carroll JF, Hall JE. Enhanced vascular reactivity and Ca2+ entry with low-salt diet: effect of obesity. Hypertension. 1999 Oct; 34(4 Pt 2):882-8. PMID: 10523378.
    Citations: 1     Fields:    Translation:Animals
  145. Crews JK, Murphy JG, Khalil RA. Gender differences in Ca(2+) entry mechanisms of vasoconstriction in Wistar-Kyoto and spontaneously hypertensive rats. Hypertension. 1999 Oct; 34(4 Pt 2):931-6. PMID: 10523387.
    Citations: 19     Fields:    Translation:Animals
  146. Crews JK, Khalil RA. Gender-specific inhibition of Ca2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin Exp Pharmacol Physiol. 1999 Sep; 26(9):707-15. PMID: 10499160.
    Citations: 39     Fields:    Translation:Animals
  147. Crews JK, Khalil RA. Antagonistic effects of 17 beta-estradiol, progesterone, and testosterone on Ca2+ entry mechanisms of coronary vasoconstriction. Arterioscler Thromb Vasc Biol. 1999 Apr; 19(4):1034-40. PMID: 10195933.
    Citations: 47     Fields:    Translation:AnimalsCells
  148. Crews JK, Novak J, Granger JP, Khalil RA. Stimulated mechanisms of Ca2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats. Am J Physiol. 1999 02; 276(2):R530-8. PMID: 9950934.
    Citations: 10     Fields:    Translation:Animals
  149. Kanashiro CA, Khalil RA. Isoform-specific protein kinase C activity at variable Ca2+ entry during coronary artery contraction by vasoactive eicosanoids. Can J Physiol Pharmacol. 1998 Dec; 76(12):1110-9. PMID: 10326833.
    Citations:    Fields:    Translation:AnimalsCells
  150. Kanashiro CA, Khalil RA. Signal transduction by protein kinase C in mammalian cells. Clin Exp Pharmacol Physiol. 1998 Dec; 25(12):974-85. PMID: 9887993.
    Citations: 23     Fields:    Translation:AnimalsCells
  151. Khalil RA, Crews JK, Novak J, Kassab S, Granger JP. Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats. Hypertension. 1998 May; 31(5):1065-9. PMID: 9576115.
    Citations: 33     Fields:    Translation:Animals
  152. Mii S, Khalil RA, Morgan KG, Ware JA, Kent KC. Mitogen-activated protein kinase and proliferation of human vascular smooth muscle cells. Am J Physiol. 1996 Jan; 270(1 Pt 2):H142-50. PMID: 8769745.
    Citations: 15     Fields:    Translation:HumansCells
  153. Khalil RA, Menice CB, Wang CL, Morgan KG. Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells. Circ Res. 1995 Jun; 76(6):1101-8. PMID: 7538916.
    Citations: 23     Fields:    Translation:AnimalsCells
  154. Khalil RA, Lajoie C, Morgan KG. In situ determination of [Ca2+]i threshold for translocation of the alpha-protein kinase C isoform. Am J Physiol. 1994 Jun; 266(6 Pt 1):C1544-51. PMID: 8023886.
    Citations: 19     Fields:    Translation:AnimalsCells
  155. Khalil RA, Morgan KG. PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation. Am J Physiol. 1993 Aug; 265(2 Pt 1):C406-11. PMID: 8368270.
    Citations: 25     Fields:    Translation:AnimalsCells
  156. Khalil RA, Lajoie C, Resnick MS, Morgan KG. Ca(2+)-independent isoforms of protein kinase C differentially translocate in smooth muscle. Am J Physiol. 1992 Sep; 263(3 Pt 1):C714-9. PMID: 1415520.
    Citations: 40     Fields:    Translation:Animals
  157. Khalil RA, Morgan KG. Phenylephrine-induced translocation of protein kinase C and shortening of two types of vascular cells of the ferret. J Physiol. 1992 Sep; 455:585-99. PMID: 1484363.
    Citations: 12     Fields:    Translation:AnimalsCells
  158. Morgan KG, Khalil RA, Suematsu E, Katsuyama H. Calcium-dependent and calcium-independent pathways of signal transduction in smooth muscle. Jpn J Pharmacol. 1992; 58 Suppl 2:47P-53P. PMID: 1507643.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  159. Khalil RA, Morgan KG. Imaging of protein kinase C distribution and translocation in living vascular smooth muscle cells. Circ Res. 1991 Dec; 69(6):1626-31. PMID: 1954682.
    Citations: 9     Fields:    Translation:AnimalsCells
  160. Khalil RA, van Breemen C. Intracellular free calcium concentration/force relationship in rabbit inferior vena cava activated by norepinephrine and high K+. Pflugers Arch. 1990 Aug; 416(6):727-34. PMID: 2247344.
    Citations: 13     Fields:    Translation:Animals
  161. Nishimura J, Khalil RA, Drenth JP, van Breemen C. Evidence for increased myofilament Ca2+ sensitivity in norepinephrine-activated vascular smooth muscle. Am J Physiol. 1990 Jul; 259(1 Pt 2):H2-8. PMID: 2115742.
    Citations: 15     Fields:    Translation:AnimalsCells
  162. Nishimura J, Khalil RA, van Breemen C. Agonist-induced vascular tone. Hypertension. 1989 Jun; 13(6 Pt 2):835-44. PMID: 2544524.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  163. Khalil RA, van Breemen C. Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation? J Pharmacol Exp Ther. 1988 Feb; 244(2):537-42. PMID: 3346836.
    Citations: 29     Fields:    Translation:AnimalsCells
  164. Khalil R, Lodge N, Saida K, van Breemen C. Mechanism of calcium activation in vascular smooth muscle. J Hypertens Suppl. 1987 Dec; 5(4):S5-15. PMID: 2450186.
    Citations: 8     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.