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profileRaouf A. Khalil, Ph.D., M.D.

TitleAssociate Professor of Surgery
InstitutionBrigham and Women's Hospital
DepartmentSurgery
AddressBrigham and Womens Hospital
Vascular Surgery
221 Longwood Ave
Boston MA 02115
Phone617/525-8530
Fax617/264-5124
vCardDownload vCard (login for email)

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Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21HL111775     (KHALIL, RAOUF A)Feb 1, 2013 - Jan 31, 2015
NIH/NHLBI
Mechano-Sensitive Hypoxia-Inducible Factor-MMP Pathway in Venous Insufficiency
Role: Principal Investigator

R21HL098724     (KHALIL, RAOUF A)Aug 6, 2010 - Apr 30, 2014
NIH/NHLBI
Role of Endothelin B Receptor in Vascular Protection in Females
Role: Principal Investigator

R03HD060702     (KHALIL, RAOUF A)May 8, 2009 - Apr 30, 2012
NIH/NICHD
Vascular Angiotensin Type-2 Receptor in Normal and Hypertensive Pregnancy
Role: Principal Investigator

R01HL070659     (KHALIL, RAOUF A.)Jul 1, 2003 - Jun 30, 2009
NIH/NHLBI
Vascular Protective Role of Endothelin B Receptors
Role: Principal Investigator

R01HL065998     (KHALIL, RAOUF A)Dec 1, 2000 - May 31, 2017
NIH/NHLBI
Vascular Mechanisms in Pregnancy-Induced Hypertension
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li W, Cui N, Mazzuca MQ, Mata KM, Khalil RA. Increased vascular and uteroplacental matrix metalloproteinase-1 and -7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-a. Am J Physiol Heart Circ Physiol. 2017 Sep 01; 313(3):H491-H507. PMID: 28626073.
    View in: PubMed
  2. Chen J, Khalil RA. Matrix Metalloproteinases in Normal Pregnancy and Preeclampsia. Prog Mol Biol Transl Sci. 2017; 148:87-165. PMID: 28662830.
    View in: PubMed
  3. Chen J, Ren Z, Zhu M, Khalil RA. Decreased homodimerization and increased TIMP-1 complexation of uteroplacental and uterine arterial matrix metalloproteinase-9 during hypertension-in-pregnancy. Biochem Pharmacol. 2017 Aug 15; 138:81-95. PMID: 28506758.
    View in: PubMed
  4. Liu J, Khalil RA. Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders. Prog Mol Biol Transl Sci. 2017; 148:355-420. PMID: 28662828.
    View in: PubMed
  5. Rong D, Liu J, Jia X, Al-Nafisee D, Jia S, Sun G, Li Y, Lu W, Li H, Zhang H, Ma X, Xiong J, Liu X, Khalil RA, Guo W. Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease in a Chinese Han population. Atherosclerosis. 2017 Aug; 263:205-210. PMID: 28651188.
    View in: PubMed
  6. Cui N, Hu M, Khalil RA. Biochemical and Biological Attributes of Matrix Metalloproteinases. Prog Mol Biol Transl Sci. 2017; 147:1-73. PMID: 28413025.
    View in: PubMed
  7. Chen Y, Peng W, Raffetto JD, Khalil RA. Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease. Prog Mol Biol Transl Sci. 2017; 147:267-299. PMID: 28413031.
    View in: PubMed
  8. Khalil RA. Preface. Prog Mol Biol Transl Sci. 2017; 148:xi-xii. PMID: 28662831.
    View in: PubMed
  9. Khalil RA. Preface. Prog Mol Biol Transl Sci. 2017; 147:xi-xii. PMID: 28413033.
    View in: PubMed
  10. Ren Z, Chen J, Khalil RA. Zymography as a Research Tool in the Study of Matrix Metalloproteinase Inhibitors. Methods Mol Biol. 2017; 1626:79-102. PMID: 28608202.
    View in: PubMed
  11. Khalil RA. Preface. Adv Pharmacol. 2017; 78:xi-xii. PMID: 28212805.
    View in: PubMed
  12. Anwar MA, Vorkas PA, Li J, Adesina-Georgiadis KN, Reslan OM, Raffetto JD, Want EJ, Khalil RA, Holmes E, Davies AH. Prolonged Mechanical Circumferential Stretch Induces Metabolic Changes in Rat Inferior Vena Cava. Eur J Vasc Endovasc Surg. 2016 Oct; 52(4):544-552. PMID: 27523725.
    View in: PubMed
  13. Ringvold HC, Khalil RA. Protein Kinase C as Regulator of Vascular Smooth Muscle Function and Potential Target in Vascular Disorders. Adv Pharmacol. 2017; 78:203-301. PMID: 28212798.
    View in: PubMed
  14. Possomato-Vieira JS, Khalil RA. Mechanisms of Endothelial Dysfunction in Hypertensive Pregnancy and Preeclampsia. Adv Pharmacol. 2016; 77:361-431. PMID: 27451103; PMCID: PMC4965238 [Available on 06/14/17].
  15. Zhu M, Ren Z, Possomato-Vieira JS, Khalil RA. Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2016 Sep 01; 311(3):R505-21. PMID: 27280428.
    View in: PubMed
  16. Xia Y, Khalil RA. Pregnancy-associated adaptations in [Ca2+]i-dependent and Ca2+ sensitization mechanisms of venous contraction: implications in pregnancy-related venous disorders. Am J Physiol Heart Circ Physiol. 2016 Jun 01; 310(11):H1851-65. PMID: 27199130; PMCID: PMC4935520 [Available on 06/01/17].
  17. Khalil RA. Preface. Adv Pharmacol. 2016; 77:xiii-xiv. PMID: 27451104.
    View in: PubMed
  18. Mata KM, Li W, Reslan OM, Siddiqui WT, Opsasnick LA, Khalil RA. Adaptive increases in expression and vasodilator activity of estrogen receptor subtypes in a blood vessel-specific pattern during pregnancy. Am J Physiol Heart Circ Physiol. 2015 Nov 15; 309(10):H1679-96. PMID: 26408543; PMCID: PMC4666980 [Available on 11/15/16].
  19. MacColl E, Khalil RA. Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease. J Pharmacol Exp Ther. 2015 Dec; 355(3):410-28. PMID: 26319699; PMCID: PMC4658486 [Available on 12/01/16].
  20. Ali SM, Khalil RA. Genetic, immune and vasoactive factors in the vascular dysfunction associated with hypertension in pregnancy. Expert Opin Ther Targets. 2015; 19(11):1495-515. PMID: 26294111; PMCID: PMC4640938 [Available on 11/01/16].
  21. Pojoga LH, Yao TM, Opsasnick LA, Siddiqui WT, Reslan OM, Adler GK, Williams GH, Khalil RA. Cooperative Role of Mineralocorticoid Receptor and Caveolin-1 in Regulating the Vascular Response to Low Nitric Oxide-High Angiotensin II-Induced Cardiovascular Injury. J Pharmacol Exp Ther. 2015 Oct; 355(1):32-47. PMID: 26183312; PMCID: PMC4576669 [Available on 10/01/16].
  22. Garza AE, Pojoga LH, Moize B, Hafiz WM, Opsasnick LA, Siddiqui WT, Horenstein M, Adler GK, Williams GH, Khalil RA. Critical Role of Striatin in Blood Pressure and Vascular Responses to Dietary Sodium Intake. Hypertension. 2015 Sep; 66(3):674-80. PMID: 26169051; PMCID: PMC4537321.
  23. Shah DA, Khalil RA. Bioactive factors in uteroplacental and systemic circulation link placental ischemia to generalized vascular dysfunction in hypertensive pregnancy and preeclampsia. Biochem Pharmacol. 2015 Jun 15; 95(4):211-26. PMID: 25916268; PMCID: PMC4449835.
  24. Mazzuca MQ, Mata KM, Li W, Rangan SS, Khalil RA. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther. 2015 Feb; 352(2):291-304. PMID: 25472954; PMCID: PMC4293436.
  25. Mazzuca MQ, Li W, Reslan OM, Yu P, Mata KM, Khalil RA. Downregulation of microvascular endothelial type B endothelin receptor is a central vascular mechanism in hypertensive pregnancy. Hypertension. 2014 Sep; 64(3):632-43. PMID: 24914193; PMCID: PMC4134432.
  26. Li W, Mata KM, Mazzuca MQ, Khalil RA. Altered matrix metalloproteinase-2 and -9 expression/activity links placental ischemia and anti-angiogenic sFlt-1 to uteroplacental and vascular remodeling and collagen deposition in hypertensive pregnancy. Biochem Pharmacol. 2014 Jun 01; 89(3):370-85. PMID: 24704473; PMCID: PMC4034157.
  27. Ou M, Dang Y, Mazzuca MQ, Basile R, Khalil RA. Adaptive regulation of endothelin receptor type-A and type-B in vascular smooth muscle cells during pregnancy in rats. J Cell Physiol. 2014 Apr; 229(4):489-501. PMID: 24105843; PMCID: PMC3867575.
  28. Khalil RA. Understanding basic muscle electrophysiology while keeping an eye on diseases of the heart, lung and blood. Recent Pat Cardiovasc Drug Discov. 2014; 9(1):1. PMID: 25600348.
    View in: PubMed
  29. Pojoga LH, Yao TM, Opsasnick LA, Garza AE, Reslan OM, Adler GK, Williams GH, Khalil RA. Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice. J Pharmacol Exp Ther. 2014 Feb; 348(2):260-70. PMID: 24281385; PMCID: PMC3912545.
  30. Khalil RA. Estrogen, vascular estrogen receptor and hormone therapy in postmenopausal vascular disease. Biochem Pharmacol. 2013 Dec 15; 86(12):1627-42. PMID: 24099797; PMCID: PMC3840081.
  31. Dang Y, Li W, Tran V, Khalil RA. EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone. Biochem Pharmacol. 2013 Sep 15; 86(6):734-47. PMID: 23856290; PMCID: PMC3812432.
  32. Mazzuca MQ, Dang Y, Khalil RA. Enhanced endothelin receptor type B-mediated vasodilation and underlying [Ca²?]i in mesenteric microvessels of pregnant rats. Br J Pharmacol. 2013 Jul; 169(6):1335-51. PMID: 23646960; PMCID: PMC3831712.
  33. Reslan OM, Yin Z, do Nascimento GR, Khalil RA. Subtype-specific estrogen receptor-mediated vasodilator activity in the cephalic, thoracic, and abdominal vasculature of female rat. J Cardiovasc Pharmacol. 2013 Jul; 62(1):26-40. PMID: 23429596; PMCID: PMC3664271.
  34. Khalil RA. Novel therapies and botanical and mechanical approaches for management of cardiovascular disease. Recent Pat Cardiovasc Drug Discov. 2013 Apr; 8(1):1. PMID: 23721364.
    View in: PubMed
  35. Kucukguven A, Khalil RA. Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins. Curr Drug Targets. 2013 Mar; 14(3):287-324. PMID: 23316963; PMCID: PMC3584231.
  36. Khalil RA. Protein Kinase C Inhibitors as Modulators of Vascular Function and their Application in Vascular Disease. Pharmaceuticals (Basel). 2013; 6(3):407-39. PMID: 23580870; PMCID: PMC3619439.
  37. Anwar MA, Vorkas P, Li J, Resslan O, Want E, Raffetto JD, Khalil RA, Holmes E, Davies AH. Prolonged Mechanical Stretch Alters the Metabolic Profile in Rat Inferior Vena Cava. J Vasc Surg Venous Lymphat Disord. 2013 Jan; 1(1):105-6. PMID: 26993918.
    View in: PubMed
  38. Majed BH, Khalil RA. Molecular mechanisms regulating the vascular prostacyclin pathways and their adaptation during pregnancy and in the newborn. Pharmacol Rev. 2012 Jul; 64(3):540-82. PMID: 22679221; PMCID: PMC3400831.
  39. Yin Z, Sada AA, Reslan OM, Narula N, Khalil RA. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 01; 303(1):E55-70. PMID: 22496348; PMCID: PMC3404560.
  40. Mazzuca MQ, Khalil RA. Vascular endothelin receptor type B: structure, function and dysregulation in vascular disease. Biochem Pharmacol. 2012 Jul 15; 84(2):147-62. PMID: 22484314; PMCID: PMC3358417.
  41. Reslan OM, Khalil RA. Vascular effects of estrogenic menopausal hormone therapy. Rev Recent Clin Trials. 2012 Feb; 7(1):47-70. PMID: 21864249; PMCID: PMC3227781.
  42. Gencel VB, Benjamin MM, Bahou SN, Khalil RA. Vascular effects of phytoestrogens and alternative menopausal hormone therapy in cardiovascular disease. Mini Rev Med Chem. 2012 Feb; 12(2):149-74. PMID: 22070687; PMCID: PMC3288319.
  43. Christou H, Reslan OM, Mam V, Tanbe AF, Vitali SH, Touma M, Arons E, Mitsialis SA, Kourembanas S, Khalil RA. Improved pulmonary vascular reactivity and decreased hypertrophic remodeling during nonhypercapnic acidosis in experimental pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2012 May 01; 302(9):L875-90. PMID: 22287610; PMCID: PMC3362160.
  44. Benjamin MM, Khalil RA. Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease. EXS. 2012; 103:209-79. PMID: 22642194; PMCID: PMC3367802.
  45. Raffetto JD, Yu P, Reslan OM, Xia Y, Khalil RA. Endothelium-dependent nitric oxide and hyperpolarization-mediated venous relaxation pathways in rat inferior vena cava. J Vasc Surg. 2012 Jun; 55(6):1716-25. PMID: 22209615; PMCID: PMC3320697.
  46. Khalil RA. Modulators of the vascular endothelin receptor in blood pressure regulation and hypertension. Curr Mol Pharmacol. 2011 Nov; 4(3):176-86. PMID: 21222646; PMCID: PMC3134623.
  47. Pojoga LH, Williams JS, Yao TM, Kumar A, Raffetto JD, do Nascimento GR, Reslan OM, Adler GK, Williams GH, Shi Y, Khalil RA. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension. Am J Physiol Heart Circ Physiol. 2011 Nov; 301(5):H1862-71. PMID: 21873498; PMCID: PMC3213961.
  48. Bafford R, Sui XX, Park M, Miyahara T, Newfell BG, Jaffe IZ, Romero JR, Adler GK, Williams GH, Khalil RA, Conte MS. Mineralocorticoid receptor expression in human venous smooth muscle cells: a potential role for aldosterone signaling in vein graft arterialization. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H41-7. PMID: 21536849; PMCID: PMC3129925.
  49. Raffetto JD, Khalil RA. Ca(2+)-dependent contraction by the saponoside escin in rat vena cava: implications in venotonic treatment of varicose veins. J Vasc Surg. 2011 Aug; 54(2):489-96. PMID: 21498026; PMCID: PMC3140579.
  50. Lim CS, Qiao X, Reslan OM, Xia Y, Raffetto JD, Paleolog E, Davies AH, Khalil RA. Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava. J Vasc Surg. 2011 Mar; 53(3):764-73. PMID: 21106323; PMCID: PMC3058747.
  51. Christou HA, Khalil RA. Sex hormones and vascular protection in pulmonary arterial hypertension. J Cardiovasc Pharmacol. 2010 Nov; 56(5):471-4. PMID: 20881609; PMCID: PMC2978262.
  52. Masood DE, Roach EC, Beauregard KG, Khalil RA. Impact of sex hormone metabolism on the vascular effects of menopausal hormone therapy in cardiovascular disease. Curr Drug Metab. 2010 Oct; 11(8):693-714. PMID: 21189141; PMCID: PMC3063102.
  53. Reslan OM, Khalil RA. Molecular and vascular targets in the pathogenesis and management of the hypertension associated with preeclampsia. Cardiovasc Hematol Agents Med Chem. 2010 Oct 01; 8(4):204-26. PMID: 20923405; PMCID: PMC2951603.
  54. Ma Y, Qiao X, Falone AE, Reslan OM, Sheppard SJ, Khalil RA. Gender-specific reduction in contraction is associated with increased estrogen receptor expression in single vascular smooth muscle cells of female rat. Cell Physiol Biochem. 2010; 26(3):457-70. PMID: 20798531; PMCID: PMC2929922.
  55. Pojoga LH, Adamov√° Z, Kumar A, Stennett AK, Romero JR, Adler GK, Williams GH, Khalil RA. Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2010 Jun; 298(6):H1776-88. PMID: 20363891; PMCID: PMC2886646.
  56. Raffetto JD, Qiao X, Beauregard KG, Khalil RA. Estrogen receptor-mediated enhancement of venous relaxation in female rat: implications in sex-related differences in varicose veins. J Vasc Surg. 2010 Apr; 51(4):972-81. PMID: 20347696; PMCID: PMC2847594.
  57. Raffetto JD, Qiao X, Beauregard KG, Tanbe AF, Kumar A, Mam V, Khalil RA. Functional adaptation of venous smooth muscle response to vasoconstriction in proximal, distal, and varix segments of varicose veins. J Vasc Surg. 2010 Apr; 51(4):962-71. PMID: 20347695; PMCID: PMC2847596.
  58. Sheppard SJ, Khalil RA. Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy. Cardiovasc Hematol Disord Drug Targets. 2010 Mar; 10(1):33-52. PMID: 20041838; PMCID: PMC2855626.
  59. Tanbe AF, Khalil RA. Circulating and Vascular Bioactive Factors during Hypertension in Pregnancy. Curr Bioact Compd. 2010 Mar 01; 6(1):60-75. PMID: 20419111.
    View in: PubMed
  60. Khalil RA. Potential approaches to enhance the effects of estrogen on senescent blood vessels and postmenopausal cardiovascular disease. Cardiovasc Hematol Agents Med Chem. 2010 Jan; 8(1):29-46. PMID: 20210774; PMCID: PMC2853974.
  61. Mam V, Tanbe AF, Vitali SH, Arons E, Christou HA, Khalil RA. Impaired vasoconstriction and nitric oxide-mediated relaxation in pulmonary arteries of hypoxia- and monocrotaline-induced pulmonary hypertensive rats. J Pharmacol Exp Ther. 2010 Feb; 332(2):455-62. PMID: 19915069; PMCID: PMC2812110.
  62. do Nascimento GR, Barros YV, Wells AK, Khalil RA. Research into Specific Modulators of Vascular Sex Hormone Receptors in the Management of Postmenopausal Cardiovascular Disease. Curr Hypertens Rev. 2009 Nov; 5(4):283-306. PMID: 20694192.
    View in: PubMed
  63. Xia Y, Khalil RA. Sex-related decrease in [Ca2+]i signaling and Ca2+-dependent contraction in inferior vena cava of female rat. Am J Physiol Regul Integr Comp Physiol. 2010 Jan; 298(1):R15-24. PMID: 19864336; PMCID: PMC2806211.
  64. Adamova Z, Ozkan S, Khalil RA. Vascular and cellular calcium in normal and hypertensive pregnancy. Curr Clin Pharmacol. 2009 Sep; 4(3):172-90. PMID: 19500073; PMCID: PMC2852626.
  65. Sprague AH, Khalil RA. Inflammatory cytokines in vascular dysfunction and vascular disease. Biochem Pharmacol. 2009 Sep 15; 78(6):539-52. PMID: 19413999; PMCID: PMC2730638.
  66. Ponnuchamy B, Khalil RA. Cellular mediators of renal vascular dysfunction in hypertension. Am J Physiol Regul Integr Comp Physiol. 2009 Apr; 296(4):R1001-18. PMID: 19225145; PMCID: PMC2698613.
  67. Stennett AK, Qiao X, Falone AE, Koledova VV, Khalil RA. Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats. Am J Physiol Heart Circ Physiol. 2009 Mar; 296(3):H745-55. PMID: 19151255; PMCID: PMC2660233.
  68. Smiley DA, Khalil RA. Estrogenic compounds, estrogen receptors and vascular cell signaling in the aging blood vessels. Curr Med Chem. 2009; 16(15):1863-87. PMID: 19442151; PMCID: PMC2852629.
  69. Serock MR, Wells AK, Khalil RA. Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov; 3(3):165-86. PMID: 18991792.
    View in: PubMed
  70. Ross RL, Serock MR, Khalil RA. Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease. Curr Cardiol Rev. 2008 Nov; 4(4):309-22. PMID: 20066139; PMCID: PMC2801863.
  71. Raffetto JD, Barros YV, Wells AK, Khalil RA. MMP-2 induced vein relaxation via inhibition of [Ca2+]e-dependent mechanisms of venous smooth muscle contraction. Role of RGD peptides. J Surg Res. 2010 Apr; 159(2):755-64. PMID: 19482300; PMCID: PMC2844458.
  72. Chen W, Khalil RA. Differential [Ca2+]i signaling of vasoconstriction in mesenteric microvessels of normal and reduced uterine perfusion pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2008 Dec; 295(6):R1962-72. PMID: 18843089; PMCID: PMC2685295.
  73. Raffetto JD, Khalil RA. Matrix metalloproteinases in venous tissue remodeling and varicose vein formation. Curr Vasc Pharmacol. 2008 Jul; 6(3):158-72. PMID: 18673156.
    View in: PubMed
  74. Ponnuchamy B, Khalil RA. Role of ADAMs in endothelial cell permeability: cadherin shedding and leukocyte rolling. Circ Res. 2008 May 23; 102(10):1139-42. PMID: 18497310; PMCID: PMC2746645.
  75. Raffetto JD, Qiao X, Koledova VV, Khalil RA. Prolonged increases in vein wall tension increase matrix metalloproteinases and decrease constriction in rat vena cava: Potential implications in varicose veins. J Vasc Surg. 2008 Aug; 48(2):447-56. PMID: 18502086; PMCID: PMC2575039.
  76. Pojoga LH, Yao TM, Sinha S, Ross RL, Lin JC, Raffetto JD, Adler GK, Williams GH, Khalil RA. Effect of dietary sodium on vasoconstriction and eNOS-mediated vascular relaxation in caveolin-1-deficient mice. Am J Physiol Heart Circ Physiol. 2008 Mar; 294(3):H1258-65. PMID: 18178722; PMCID: PMC2268616.
  77. Qiao X, McConnell KR, Khalil RA. Sex steroids and vascular responses in hypertension and aging. Gend Med. 2008; 5 Suppl A:S46-64. PMID: 18395683.
    View in: PubMed
  78. Raffetto JD, Khalil RA. Mechanisms of varicose vein formation: valve dysfunction and wall dilation. Phlebology. 2008; 23(2):85-98. PMID: 18453484.
    View in: PubMed
  79. Raffetto JD, Khalil RA. Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem Pharmacol. 2008 Jan 15; 75(2):346-59. PMID: 17678629; PMCID: PMC2254136.
  80. Koledova VV, Khalil RA. Sex hormone replacement therapy and modulation of vascular function in cardiovascular disease. Expert Rev Cardiovasc Ther. 2007 Jul; 5(4):777-89. PMID: 17605655.
    View in: PubMed
  81. Claro S, Kanashiro CA, Oshiro ME, Ferreira AT, Khalil RA. alpha- and epsilon-protein kinase C activity during smooth muscle cell apoptosis in response to gamma-radiation. J Pharmacol Exp Ther. 2007 Sep; 322(3):964-72. PMID: 17600140.
    View in: PubMed
  82. Khalil RA. Sex hormones, vascular function and the outcome of hormone replacement therapy in cardiovascular disease. Future Cardiol. 2007 May; 3(3):283-300. PMID: 19804220.
    View in: PubMed
  83. Raffetto JD, Ross RL, Khalil RA. Matrix metalloproteinase 2-induced venous dilation via hyperpolarization and activation of K+ channels: relevance to varicose vein formation. J Vasc Surg. 2007 Feb; 45(2):373-80. PMID: 17264019; PMCID: PMC1794684.
  84. Koledova VV, Khalil RA. Ca2+, calmodulin, and cyclins in vascular smooth muscle cell cycle. Circ Res. 2006 May 26; 98(10):1240-3. PMID: 16728669; PMCID: PMC1474836.
  85. Stennett AK, Khalil RA. Neurovascular mechanisms of hypertension in pregnancy. Curr Neurovasc Res. 2006 May; 3(2):131-48. PMID: 16719796.
    View in: PubMed
  86. Khalil RA. Dietary salt and hypertension: new molecular targets add more spice. Am J Physiol Regul Integr Comp Physiol. 2006 Mar; 290(3):R509-13. PMID: 16467497.
    View in: PubMed
  87. Hynynen MM, Khalil RA. The vascular endothelin system in hypertension--recent patents and discoveries. Recent Pat Cardiovasc Drug Discov. 2006 Jan; 1(1):95-108. PMID: 17200683; PMCID: PMC1351106.
  88. Salamanca DA, Khalil RA. Protein kinase C isoforms as specific targets for modulation of vascular smooth muscle function in hypertension. Biochem Pharmacol. 2005 Nov 25; 70(11):1537-47. PMID: 16139252; PMCID: PMC1343531.
  89. Khalil RA. Sex hormones as potential modulators of vascular function in hypertension. Hypertension. 2005 Aug; 46(2):249-54. PMID: 15983238; PMCID: PMC1249514.
  90. Chew DK, Conte MS, Khalil RA. Matrix metalloproteinase-specific inhibition of Ca2+ entry mechanisms of vascular contraction. J Vasc Surg. 2004 Nov; 40(5):1001-10. PMID: 15557917.
    View in: PubMed
  91. Orshal JM, Khalil RA. Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2004 Jun; 286(6):R1013-23. PMID: 15142856.
    View in: PubMed
  92. Chew DK, Orshal JM, Khalil RA. Elastase promotes aortic dilation by inhibiting Ca2+ influx into vascular smooth muscle. J Cardiovasc Pharmacol. 2004 Apr; 43(4):504-13. PMID: 15085061.
    View in: PubMed
  93. McNair LL, Salamanca DA, Khalil RA. Endothelin-1 promotes Ca2+ antagonist-insensitive coronary smooth muscle contraction via activation of epsilon-protein kinase C. Hypertension. 2004 Apr; 43(4):897-904. PMID: 14981072.
    View in: PubMed
  94. Orshal JM, Khalil RA. Gender, sex hormones, and vascular tone. Am J Physiol Regul Integr Comp Physiol. 2004 Feb; 286(2):R233-49. PMID: 14707008.
    View in: PubMed
  95. Orshal JM, Khalil RA. Reduced endothelial NO-cGMP-mediated vascular relaxation and hypertension in IL-6-infused pregnant rats. Hypertension. 2004 Feb; 43(2):434-44. PMID: 14707155.
    View in: PubMed
  96. Payne JA, Alexander BT, Khalil RA. Decreased endothelium-dependent NO-cGMP vascular relaxation and hypertension in growth-restricted rats on a high-salt diet. Hypertension. 2004 Feb; 43(2):420-7. PMID: 14707161.
    View in: PubMed
  97. Wynne FL, Payne JA, Cain AE, Reckelhoff JF, Khalil RA. Age-related reduction in estrogen receptor-mediated mechanisms of vascular relaxation in female spontaneously hypertensive rats. Hypertension. 2004 Feb; 43(2):405-12. PMID: 14699001.
    View in: PubMed
  98. Dallas A, Khalil RA. Ca2+ antagonist-insensitive coronary smooth muscle contraction involves activation of epsilon-protein kinase C-dependent pathway. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1454-63. PMID: 14600078.
    View in: PubMed
  99. Chew DK, Orshal JM, Khalil RA. Elastase-induced suppression of endothelin-mediated Ca2+ entry mechanisms of vascular contraction. Hypertension. 2003 Oct; 42(4):818-24. PMID: 12900430.
    View in: PubMed
  100. Payne JA, Alexander BT, Khalil RA. Reduced endothelial vascular relaxation in growth-restricted offspring of pregnant rats with reduced uterine perfusion. Hypertension. 2003 Oct; 42(4):768-74. PMID: 12874089.
    View in: PubMed
  101. Payne JA, Reckelhoff JF, Khalil RA. Role of oxidative stress in age-related reduction of NO-cGMP-mediated vascular relaxation in SHR. Am J Physiol Regul Integr Comp Physiol. 2003 Sep; 285(3):R542-51. PMID: 12816742.
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  102. Wynne FL, Khalil RA. Testosterone and coronary vascular tone: implications in coronary artery disease. J Endocrinol Invest. 2003 Feb; 26(2):181-6. PMID: 12739749.
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  103. Thompson J, Khalil RA. Gender differences in the regulation of vascular tone. Clin Exp Pharmacol Physiol. 2003 Jan-Feb; 30(1-2):1-15. PMID: 12542447.
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  104. Smith L, Payne JA, Sedeek MH, Granger JP, Khalil RA. Endothelin-induced increases in Ca2+ entry mechanisms of vascular contraction are enhanced during high-salt diet. Hypertension. 2003 Mar; 41(3 Pt 2):787-93. PMID: 12623997.
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  105. Tian N, Gannon AW, Khalil RA, Manning RD. Mechanisms of salt-sensitive hypertension: role of renal medullary inducible nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol. 2003 Feb; 284(2):R372-9. PMID: 12399250.
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  106. Murphy JG, Herrington JN, Granger JP, Khalil RA. Enhanced [Ca2+]i in renal arterial smooth muscle cells of pregnant rats with reduced uterine perfusion pressure. Am J Physiol Heart Circ Physiol. 2003 Jan; 284(1):H393-403. PMID: 12388289.
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  107. Giardina JB, Green GM, Cockrell KL, Granger JP, Khalil RA. TNF-alpha enhances contraction and inhibits endothelial NO-cGMP relaxation in systemic vessels of pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2002 Jul; 283(1):R130-43. PMID: 12069938.
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  108. Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of preeclampsia: linking placental ischemia/hypoxia with microvascular dysfunction. Microcirculation. 2002 Jul; 9(3):147-60. PMID: 12080413.
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  109. Coleman DA, Khalil RA. Physiologic increases in extracellular sodium salt enhance coronary vasoconstriction and Ca2+ entry. J Cardiovasc Pharmacol. 2002 Jul; 40(1):58-66. PMID: 12072578.
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  110. Khalil RA, Granger JP. Vascular mechanisms of increased arterial pressure in preeclampsia: lessons from animal models. Am J Physiol Regul Integr Comp Physiol. 2002 Jul; 283(1):R29-45. PMID: 12069928.
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  111. Giardina JB, Cockrell KL, Granger JP, Khalil RA. Low-salt diet enhances vascular reactivity and Ca(2+) entry in pregnant rats with normal and reduced uterine perfusion pressure. Hypertension. 2002 Feb; 39(2 Pt 2):368-74. PMID: 11882575.
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  112. Cain AE, Tanner DM, Khalil RA. Endothelin-1--induced enhancement of coronary smooth muscle contraction via MAPK-dependent and MAPK-independent [Ca(2+)](i) sensitization pathways. Hypertension. 2002 Feb; 39(2 Pt 2):543-9. PMID: 11882605.
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  113. Barron LA, Green GM, Khalil RA. Gender differences in vascular smooth muscle reactivity to increases in extracellular sodium salt. Hypertension. 2002 Feb; 39(2 Pt 2):425-32. PMID: 11882584.
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  114. Davis JR, Giardina JB, Green GM, Alexander BT, Granger JP, Khalil RA. Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats. Am J Physiol Regul Integr Comp Physiol. 2002 Feb; 282(2):R390-9. PMID: 11792648.
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  115. Alexander BT, Bennett WA, Khalil RA, Granger JP. Preeclampsia: linking placental ischemia with cardiovascular-renal dysfunction. News Physiol Sci. 2001 Dec; 16:282-6. PMID: 11719606.
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  116. Barron LA, Giardina JB, Granger JP, Khalil RA. High-salt diet enhances vascular reactivity in pregnant rats with normal and reduced uterine perfusion pressure. Hypertension. 2001 Sep; 38(3 Pt 2):730-5. PMID: 11566966.
    View in: PubMed
  117. Granger JP, Alexander BT, Llinas MT, Bennett WA, Khalil RA. Pathophysiology of hypertension during preeclampsia linking placental ischemia with endothelial dysfunction. Hypertension. 2001 Sep; 38(3 Pt 2):718-22. PMID: 11566964.
    View in: PubMed
  118. Granger JP, Alexander BT, Bennett WA, Khalil RA. Pathophysiology of pregnancy-induced hypertension. Am J Hypertens. 2001 Jun; 14(6 Pt 2):178S-185S. PMID: 11411754.
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  119. Giardina JB, Green GM, Rinewalt AN, Granger JP, Khalil RA. Role of endothelin B receptors in enhancing endothelium-dependent nitric oxide-mediated vascular relaxation during high salt diet. Hypertension. 2001 Feb; 37(2 Pt 2):516-23. PMID: 11230328.
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  120. Sirous ZN, Fleming JB, Khalil RA. Endothelin-1 enhances eicosanoids-induced coronary smooth muscle contraction by activating specific protein kinase C isoforms. Hypertension. 2001 Feb; 37(2 Pt 2):497-504. PMID: 11230325.
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  121. Giardina JB, Tanner DJ, Khalil RA. Oxidized-LDL enhances coronary vasoconstriction by increasing the activity of protein kinase C isoforms alpha and epsilon. Hypertension. 2001 Feb; 37(2 Pt 2):561-8. PMID: 11230335.
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  122. Kanashiro CA, Khalil RA. Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C34-45. PMID: 11121374.
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  123. Murphy JG, Fleming JB, Cockrell KL, Granger JP, Khalil RA. [Ca(2+)](i) signaling in renal arterial smooth muscle cells of pregnant rat is enhanced during inhibition of NOS. Am J Physiol Regul Integr Comp Physiol. 2001 Jan; 280(1):R87-99. PMID: 11124138.
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  124. Murphy JG, Khalil RA. Gender-specific reduction in contractility and [Ca(2+)](i) in vascular smooth muscle cells of female rat. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C834-44. PMID: 10751331.
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  125. Kanashiro CA, Altirkawi KA, Khalil RA. Preconditioning of coronary artery against vasoconstriction by endothelin-1 and prostaglandin F2alpha during repeated downregulation of epsilon-protein kinase C. J Cardiovasc Pharmacol. 2000 Mar; 35(3):491-501. PMID: 10710137.
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  126. Kanashiro CA, Cockrell KL, Alexander BT, Granger JP, Khalil RA. Pregnancy-associated reduction in vascular protein kinase C activity rebounds during inhibition of NO synthesis. Am J Physiol Regul Integr Comp Physiol. 2000 Feb; 278(2):R295-303. PMID: 10666128.
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  127. Crews JK, Herrington JN, Granger JP, Khalil RA. Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat. Hypertension. 2000 Jan; 35(1 Pt 2):367-72. PMID: 10642326.
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  128. Murphy JG, Khalil RA. Decreased [Ca(2+)](i) during inhibition of coronary smooth muscle contraction by 17beta-estradiol, progesterone, and testosterone. J Pharmacol Exp Ther. 1999 Oct; 291(1):44-52. PMID: 10490885.
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  129. Kanashiro CA, Alexander BT, Granger JP, Khalil RA. Ca(2+)-insensitive vascular protein kinase C during pregnancy and NOS inhibition. Hypertension. 1999 Oct; 34(4 Pt 2):924-30. PMID: 10523386.
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  130. Khalil RA, Crews JK, Carroll JF, Hall JE. Enhanced vascular reactivity and Ca2+ entry with low-salt diet: effect of obesity. Hypertension. 1999 Oct; 34(4 Pt 2):882-8. PMID: 10523378.
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  131. Crews JK, Murphy JG, Khalil RA. Gender differences in Ca(2+) entry mechanisms of vasoconstriction in Wistar-Kyoto and spontaneously hypertensive rats. Hypertension. 1999 Oct; 34(4 Pt 2):931-6. PMID: 10523387.
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  132. Crews JK, Khalil RA. Gender-specific inhibition of Ca2+ entry mechanisms of arterial vasoconstriction by sex hormones. Clin Exp Pharmacol Physiol. 1999 Sep; 26(9):707-15. PMID: 10499160.
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  133. Crews JK, Khalil RA. Antagonistic effects of 17 beta-estradiol, progesterone, and testosterone on Ca2+ entry mechanisms of coronary vasoconstriction. Arterioscler Thromb Vasc Biol. 1999 Apr; 19(4):1034-40. PMID: 10195933.
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  134. Crews JK, Novak J, Granger JP, Khalil RA. Stimulated mechanisms of Ca2+ entry into vascular smooth muscle during NO synthesis inhibition in pregnant rats. Am J Physiol. 1999 Feb; 276(2 Pt 2):R530-8. PMID: 9950934.
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  135. Kanashiro CA, Khalil RA. Isoform-specific protein kinase C activity at variable Ca2+ entry during coronary artery contraction by vasoactive eicosanoids. Can J Physiol Pharmacol. 1998 Dec; 76(12):1110-9. PMID: 10326833.
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  136. Kanashiro CA, Khalil RA. Signal transduction by protein kinase C in mammalian cells. Clin Exp Pharmacol Physiol. 1998 Dec; 25(12):974-85. PMID: 9887993.
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  137. Khalil RA, Crews JK, Novak J, Kassab S, Granger JP. Enhanced vascular reactivity during inhibition of nitric oxide synthesis in pregnant rats. Hypertension. 1998 May; 31(5):1065-9. PMID: 9576115.
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  138. Mii S, Khalil RA, Morgan KG, Ware JA, Kent KC. Mitogen-activated protein kinase and proliferation of human vascular smooth muscle cells. Am J Physiol. 1996 Jan; 270(1 Pt 2):H142-50. PMID: 8769745.
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  139. Khalil RA, Menice CB, Wang CL, Morgan KG. Phosphotyrosine-dependent targeting of mitogen-activated protein kinase in differentiated contractile vascular cells. Circ Res. 1995 Jun; 76(6):1101-8. PMID: 7538916.
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  140. Khalil RA, Lajoie C, Morgan KG. In situ determination of [Ca2+]i threshold for translocation of the alpha-protein kinase C isoform. Am J Physiol. 1994 Jun; 266(6 Pt 1):C1544-51. PMID: 8023886.
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  141. Khalil RA, Morgan KG. PKC-mediated redistribution of mitogen-activated protein kinase during smooth muscle cell activation. Am J Physiol. 1993 Aug; 265(2 Pt 1):C406-11. PMID: 8368270.
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  142. Khalil RA, Lajoie C, Resnick MS, Morgan KG. Ca(2+)-independent isoforms of protein kinase C differentially translocate in smooth muscle. Am J Physiol. 1992 Sep; 263(3 Pt 1):C714-9. PMID: 1415520.
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  143. Khalil RA, Morgan KG. Phenylephrine-induced translocation of protein kinase C and shortening of two types of vascular cells of the ferret. J Physiol. 1992 Sep; 455:585-99. PMID: 1484363; PMCID: PMC1175660.
  144. Morgan KG, Khalil RA, Suematsu E, Katsuyama H. Calcium-dependent and calcium-independent pathways of signal transduction in smooth muscle. Jpn J Pharmacol. 1992; 58 Suppl 2:47P-53P. PMID: 1507643.
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  145. Khalil RA, Morgan KG. Imaging of protein kinase C distribution and translocation in living vascular smooth muscle cells. Circ Res. 1991 Dec; 69(6):1626-31. PMID: 1954682.
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  146. Khalil RA, van Breemen C. Intracellular free calcium concentration/force relationship in rabbit inferior vena cava activated by norepinephrine and high K+. Pflugers Arch. 1990 Aug; 416(6):727-34. PMID: 2247344.
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  147. Nishimura J, Khalil RA, Drenth JP, van Breemen C. Evidence for increased myofilament Ca2+ sensitivity in norepinephrine-activated vascular smooth muscle. Am J Physiol. 1990 Jul; 259(1 Pt 2):H2-8. PMID: 2115742.
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  148. Nishimura J, Khalil RA, van Breemen C. Agonist-induced vascular tone. Hypertension. 1989 Jun; 13(6 Pt 2):835-44. PMID: 2544524.
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  149. Khalil RA, van Breemen C. Sustained contraction of vascular smooth muscle: calcium influx or C-kinase activation? J Pharmacol Exp Ther. 1988 Feb; 244(2):537-42. PMID: 3346836.
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  150. Khalil R, Lodge N, Saida K, van Breemen C. Mechanism of calcium activation in vascular smooth muscle. J Hypertens Suppl. 1987 Dec; 5(4):S5-15. PMID: 2450186.
    View in: PubMed
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