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profileMonika Haack, Ph.D.

TitleAssistant Professor of Neurology
InstitutionBeth Israel Deaconess Medical Center
DepartmentNeurology
AddressBeth Israel Deaconess Med Ctr
Neurology - Dana 779
330 Brookline Ave
Boston MA 02215
Phone617/667-5234
vCardDownload vCard (login for email)

Collapse Overview 
Collapse overview
My research interest focuses on the impact of sleep quantity and quality on emotional and physical well-being, in particular pain experiences, and whether inflammatory processes link the association between sleep and pain. We study the sleep-pain relationship in experimental models of prolonged partial sleep deprivation and total sleep deprivation, and will shortly begin testing pain thresholds in patients suffering from primary insomnia. In addition to the impact of insufficient sleep on the analgesic and inflammatory system, I am interested in whether improvement of sleep quantity and quality has a beneficial influence on different systems. Currently, we are testing whether sleep extension lowers blood pressure and inflammatory markers.


Collapse Mentoring 
Collapse completed student projects
Subjective and biological response reactivity to a pain challenge in the course of repeated patterns of sleep restriction and recovery – a pilot study
Summer, 06/17/13 - 08/16/13
Actigraphy-Based Sleep Characteristics as Predictors of Inflammatory, Autonomic, and Stress Systems Activation in Individuals Suffering From Primary Insomnia
Summer, 06/01/12 - 09/01/12

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01NS091177     (HAACK, MONIKA)Apr 1, 2015 - Mar 31, 2019
NIH/NINDS
Pain Sensitization and Habituation in a Model of Experimentally-Induced Insomnia Symptoms
Role: Principal Investigator

R01HL105544     (HAACK, MONIKA)Jun 7, 2011 - May 31, 2015
NIH/NHLBI
Repeating patterns of sleep restriction and recovery - do we get used to it?
Role: Principal Investigator

M01RR001032     (SUKHATME, VIKAS P)Dec 1, 1977 - Mar 31, 2010
NIH/NCRR
General Clinical Research Center
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Alkozei A, Killgore WDS, Smith R, Dailey NS, Bajaj S, Raikes AC, Haack M. Chronic sleep restriction differentially affects implicit biases toward food among men and women: preliminary evidence. J Sleep Res. 2017 Nov 02. PMID: 29094414.
    View in: PubMed
  2. Simpson NS, Scott-Sutherland J, Gautam S, Sethna N, Haack M. Chronic exposure to insufficient sleep alters processes of pain habituation and sensitization. Pain. 2017 Sep 01. PMID: 28891869.
    View in: PubMed
  3. Yang H, Haack M, Gautam S, Meier-Ewert HK, Mullington JM. Repetitive exposure to shortened sleep leads to blunted sleep-associated blood pressure dipping. J Hypertens. 2017 Jun; 35(6):1187-1194. PMID: 28169885.
    View in: PubMed
  4. Simpson NS, Diolombi M, Scott-Sutherland J, Yang H, Bhatt V, Gautam S, Mullington J, Haack M. Repeating patterns of sleep restriction and recovery: Do we get used to it? Brain Behav Immun. 2016 Nov; 58:142-151. PMID: 27263430.
    View in: PubMed
  5. Mullington JM, Abbott SM, Carroll JE, Davis CJ, Dijk DJ, Dinges DF, Gehrman PR, Ginsburg GS, Gozal D, Haack M, Lim DC, Macrea M, Pack AI, Plante DT, Teske JA, Zee PC. Developing Biomarker Arrays Predicting Sleep and Circadian-Coupled Risks to Health. Sleep. 2016 Apr 01; 39(4):727-36. PMID: 26951388; PMCID: PMC4791606 [Available on 10/01/16].
  6. Floam S, Simpson N, Nemeth E, Scott-Sutherland J, Gautam S, Haack M. Sleep characteristics as predictor variables of stress systems markers in insomnia disorder. J Sleep Res. 2015 Jun; 24(3):296-304. PMID: 25524529.
    View in: PubMed
  7. Haack M, Serrador J, Cohen D, Simpson N, Meier-Ewert H, Mullington JM. Increasing sleep duration to lower beat-to-beat blood pressure: a pilot study. J Sleep Res. 2013 Jun; 22(3):295-304. PMID: 23171375; PMCID: PMC3582793.
  8. Haack M, Scott-Sutherland J, Santangelo G, Simpson NS, Sethna N, Mullington JM. Pain sensitivity and modulation in primary insomnia. Eur J Pain. 2012 Apr; 16(4):522-33. PMID: 22396081; PMCID: PMC3627385.
  9. Mullington JM, Simpson NS, Meier-Ewert HK, Haack M. Sleep loss and inflammation. Best Pract Res Clin Endocrinol Metab. 2010 Oct; 24(5):775-84. PMID: 21112025; PMCID: PMC3548567.
  10. Haack M, Lee E, Cohen DA, Mullington JM. Activation of the prostaglandin system in response to sleep loss in healthy humans: potential mediator of increased spontaneous pain. Pain. 2009 Sep; 145(1-2):136-41. PMID: 19560866; PMCID: PMC2737342.
  11. Mullington JM, Haack M, Toth M, Serrador JM, Meier-Ewert HK. Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation. Prog Cardiovasc Dis. 2009 Jan-Feb; 51(4):294-302. PMID: 19110131; PMCID: PMC3403737.
  12. Haack M, Sanchez E, Mullington JM. Elevated inflammatory markers in response to prolonged sleep restriction are associated with increased pain experience in healthy volunteers. Sleep. 2007 Sep; 30(9):1145-52. PMID: 17910386; PMCID: PMC1978405.
  13. Haack M, Mullington, JM. Shorter habitual sleep duration is associated with higher increase in subjective estimation of pain in response to a total sleep deprivation (TSD) challenge. Sleep. 2006; 129:A133.
  14. Schuld A, Birkmann S., Beitinger P., Haack M., Kraus T., Dalal M.A., Holsboer F., Pollmächer T. Low doses of dexamethasone affect immune parameters in the absence of immunological stimulation. Experimental and Clinical Endocrinology and Diabetes. 2006; 114(6):322-28.
  15. Meier-Ewert HK, Seo JY, Haack,M, Hyppolite G, Gervino E, Mullington JM. Habitual sleep duration predicts heart rate recovery following exercise in men. Sleep. 2006; 29:A149-150.
  16. Haack M, Mullington JM. Sustained sleep restriction reduces emotional and physical well-being. Pain. 2005 Dec 15; 119(1-3):56-64. PMID: 16297554.
    View in: PubMed
  17. Haack M, Mullington JM. Subjective estimations of pain increase in both total sleep deprivation (TSD) and partial sleep deprivation (PSD). Sleep. 2005; 28:A145.
  18. Mullington JM, Haack M, Rifai A. Diurnal rhythms of endothelial markers: Nadirs are not correlated with those of cortisol or body temperature. Sleep. 2005; 28:A70.
  19. Schuld A, Haack M, Hinze-Selch D, Mullington J, Pollmächer T. [Experimental studies on the interaction between sleep and the immune system in humans]. Psychother Psychosom Med Psychol. 2005 Jan; 55(1):29-35. PMID: 15647993.
    View in: PubMed
  20. Himmerich H, Schuld A, Haack M, Kaufmann C, Pollmächer T. Early prediction of changes in weight during six weeks of treatment with antidepressants. J Psychiatr Res. 2004 Sep-Oct; 38(5):485-9. PMID: 15380398.
    View in: PubMed
  21. Haack M, Pollmächer T, Mullington JM. Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers. Brain Behav Immun. 2004 Jul; 18(4):361-7. PMID: 15157953.
    View in: PubMed
  22. Haack M, Sanchez E, Broussard J, Regan M, Mullington JM. Sleep restriction increases IL-6 levels and pain-related symptoms in healthy volunteers. Sleep. 2004; 27:A137-A138.
  23. Broussard J, Haack M, Serrador J, Mullington J. Effects of sleep restriction on blood pressure. Sleep. 2004; 27:A171.
  24. Schuld A, Schmid DA, Haack M, Holsboer F, Friess E, Pollmächer T. Hypothalamo-pituitary-adrenal function in patients with depressive disorders is correlated with baseline cytokine levels, but not with cytokine responses to hydrocortisone. J Psychiatr Res. 2003 Nov-Dec; 37(6):463-70. PMID: 14563377.
    View in: PubMed
  25. Himmerich H, Schuld A, Haack M, Kaufmann C, Pollmächer T. Early prediction of changes in weight during six weeks of treatment with antidepressants. Pharmacopsychiatry. 2003; 36(5):235.
  26. Schuld A, Haack M, Birkmann S, Friess E, Pollmächer T. Immune-neuroendocrine interactions and their influence on the immune function in patients with depressive disorders. Pharmacopsychiatry. 2003; 36(5):263.
  27. Schuld A, Hinze-Selch D, Haack M, Dalal MA, Himmerich H, Lancel M, Pollmächer T. Sleep changes following chlorpromazine, clozapine, olanzapine or thalidomide in healthy subjects - First results from a double-blind, placebo-controlled study. Pharmacopsychiatry. 2003; 36(5):263-264.
  28. Broussard J, Haack M, Kan R, Mullington J. Early morning awakening is stressful. Sleep. 2003; 26:A205.
  29. Haack M, Broussard J, Repp A, Regan M, Connolly C, Mullington J. Increased headache frequency during chronic sleep restriction in healthy human subjects. Sleep. 2003; 26:A206.
  30. Hyppolite G, Haack M, Regan M, Kan R, Mullington J. A diurnal rhythm exists in circulating levels of lipopolysaccaride binding protein (LBP) in healthy young volunteers. Sleep. 2003; 26:A113.
  31. Straub RH, Schuld A, Mullington J, Haack M, Schölmerich J, Pollmächer T. The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects. J Endocrinol. 2002 Nov; 175(2):467-74. PMID: 12429044.
    View in: PubMed
  32. Haack M, Kraus T, Schuld A, Dalal M, Koethe D, Pollmächer T. Diurnal variations of interleukin-6 plasma levels are confounded by blood drawing procedures. Psychoneuroendocrinology. 2002 Nov; 27(8):921-31. PMID: 12383453.
    View in: PubMed
  33. Reichenberg A, Kraus T, Haack M, Schuld A, Pollmächer T, Yirmiya R. Endotoxin-induced changes in food consumption in healthy volunteers are associated with TNF-alpha and IL-6 secretion. Psychoneuroendocrinology. 2002 Nov; 27(8):945-56. PMID: 12383455.
    View in: PubMed
  34. Kraus T, Haack M, Schuld A, Hinze-Selch D, Koethe D, Pollmächer T. Body weight, the tumor necrosis factor system, and leptin production during treatment with mirtazapine or venlafaxine. Pharmacopsychiatry. 2002 Nov; 35(6):220-5. PMID: 12518269.
    View in: PubMed
  35. Pollmächer T, Haack M, Schuld A, Reichenberg A, Yirmiya R. Low levels of circulating inflammatory cytokines--do they affect human brain functions? Brain Behav Immun. 2002 Oct; 16(5):525-32. PMID: 12401466.
    View in: PubMed
  36. Haack M, Schuld A, Pollmächer T. Immunstimulation: Wirkung auf Stimmung und Gedächtnis. Psychotherapie in Psychiatrie, Psychotherapeutischer Medizin und Klinischer Psychologie. 2002; 7(2):210-218.
  37. Haack M. Interactions between the endotoxin-induced human host response and sleep, mood, and cognitive performance. 2001.
  38. Pollmächer T, Schuld A, Kraus T, Haack M, Hinze-Selch D. [On the clinical relevance of clozapine-triggered release of cytokines and soluble cytokine-receptors]. Fortschr Neurol Psychiatr. 2001 Sep; 69 Suppl 2:S65-74. PMID: 11533853.
    View in: PubMed
  39. Haack M, Schuld A, Kraus T, Pollmächer T. Effects of sleep on endotoxin-induced host responses in healthy men. Psychosom Med. 2001 Jul-Aug; 63(4):568-78. PMID: 11485110.
    View in: PubMed
  40. Dalal MA, Schuld A, Haack M, Uhr M, Geisler P, Eisensehr I, Noachtar S, Pollmächer T. Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients. Neurology. 2001 Jun 26; 56(12):1749-51. PMID: 11425946.
    View in: PubMed
  41. Kraus T, Schuld A, Haack M, Dalal E, Pollmächer T. Leptin and Psychopharmacology. Sperner-Unterweger B, Fleischhacker WW, Kaschka WP. Psychoneuroimmunology.Hypotheses and Current Research. Adv Biol Psychiatry. 2001; 20:20-29.
  42. Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, Pollmächer T. Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry. 2001 May; 58(5):445-52. PMID: 11343523.
    View in: PubMed
  43. Kraus T, Haack M, Schuld A, Hinze-Selch D, Pollmächer T. Low leptin levels but normal body mass indices in patients with depression or schizophrenia. Neuroendocrinology. 2001 Apr; 73(4):243-7. PMID: 11340338.
    View in: PubMed
  44. Kraus T, Zimmermann U, Schuld A, Haack M, Hinze-Selch D, Pollmächer T. [The physiopathology of weight regulation during treatment with psychotropic drugs]. Fortschr Neurol Psychiatr. 2001 Mar; 69(3):116-37. PMID: 11305122.
    View in: PubMed
  45. Schuld A, Kraus T, Haack M, Hinze-Selch D, Zobel AW, Holsboer F, Pollmächer T. Effects of dexamethasone on cytokine plasma levels and white blood cell counts in depressed patients. Psychoneuroendocrinology. 2001 Jan; 26(1):65-76. PMID: 11070335.
    View in: PubMed
  46. Pollmächer T, Haack M, Schuld A, Kraus T, Hinze-Selch D. Effects of antipsychotic drugs on cytokine networks. J Psychiatr Res. 2000 Nov-Dec; 34(6):369-82. PMID: 11165304.
    View in: PubMed
  47. Schuld A, Blum WF, Uhr M, Haack M, Kraus T, Holsboer F, Pollmächer T. Reduced leptin levels in human narcolepsy. Neuroendocrinology. 2000 Oct; 72(4):195-8. PMID: 11070422.
    View in: PubMed
  48. Schuld A, Kraus T, Hinze-Selch D, Haack M, Pollmächer T. Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia. Acta Psychiatr Scand. 2000 Aug; 102(2):153-5. PMID: 10937789.
    View in: PubMed
  49. Hinze-Selch D, Schuld A, Kraus T, Kühn M, Uhr M, Haack M, Pollmächer T. Effects of antidepressants on weight and on the plasma levels of leptin, TNF-alpha and soluble TNF receptors: A longitudinal study in patients treated with amitriptyline or paroxetine. Neuropsychopharmacology. 2000 Jul; 23(1):13-9. PMID: 10869882.
    View in: PubMed
  50. Schuld A, Kraus T, Haack M, Hinze-Selch D, Kühn M, Pollmächer T. Plasma levels of cytokines and soluble cytokine receptors during treatment with olanzapine. Schizophr Res. 2000 Jun 16; 43(2-3):164-6. PMID: 11001592.
    View in: PubMed
  51. Haack M, Reichenberg A, Kraus T, Schuld A, Yirmiya R, Pollmächer T. Effects of an intravenous catheter on the local production of cytokines and soluble cytokine receptors in healthy men. Cytokine. 2000 Jun; 12(6):694-8. PMID: 10843747.
    View in: PubMed
  52. Schuld A, Kühn M, Haack M, Kraus T, Hinze-Selch D, Lechner C, Pollmächer T. A comparison of the effects of clozapine and olanzapine on the EEG in patients with schizophrenia. Pharmacopsychiatry. 2000 May; 33(3):109-11. PMID: 10855462.
    View in: PubMed
  53. Pollmächer T, Schuld A, Kraus T, Haack M, Hinze-Selch D, Mullington J. Experimental immunomodulation, sleep, and sleepiness in humans. Ann N Y Acad Sci. 2000; 917:488-99. PMID: 11268376.
    View in: PubMed
  54. Schuld A, Kraus T, Haack M, Hinze-Selch D, Pollmächer T. Obstructive sleep apnea syndrome induced by clonazepam in a narcoleptic patient with REM-sleep-behavior disorder. J Sleep Res. 1999 Dec; 8(4):321-2. PMID: 10646174.
    View in: PubMed
  55. Haack M, Hinze-Selch D, Fenzel T, Kraus T, Kühn M, Schuld A, Pollmächer T. Plasma levels of cytokines and soluble cytokine receptors in psychiatric patients upon hospital admission: effects of confounding factors and diagnosis. J Psychiatr Res. 1999 Sep-Oct; 33(5):407-18. PMID: 10504009.
    View in: PubMed
  56. Pollmächer T, Kraus T, Haack M, Uhr M, Mullington J. Salmonella abortus equi endotoxin does not affect leptin plasma levels in healthy humans. J Infect Dis. 1999 Apr; 179(4):1047-8. PMID: 10068609.
    View in: PubMed
  57. Kraus T, Haack M, Schuld A, Hinze-Selch D, Kühn M, Uhr M, Pollmächer T. Body weight and leptin plasma levels during treatment with antipsychotic drugs. Am J Psychiatry. 1999 Feb; 156(2):312-4. PMID: 9989571.
    View in: PubMed
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