Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Johannes Schlondorff, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK115438 (SCHLONDORFF, JOHANNES S) Dec 6, 2017 - Nov 30, 2021
    Understanding the mechanisms of TRPC6 mediated FSGS
    Role: Principal Investigator
  2. K08DK080947 (SCHLONDORFF, JOHANNES S) Sep 30, 2008 - Sep 30, 2013
    TRPC6 Regulation and its Role in Glomerular Pathology
    Role: Principal Investigator
  3. F32DK074308 (SCHLONDORFF, JOHANNES S) Jun 30, 2006 - Jun 29, 2008
    Characterization of TRPC6 mutations in inherited FSGS
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Schlöndorff JS. My, oh, MYO9A! Just how complex can regulation of the podocyte actin cytoskeleton get? Kidney Int. 2021 05; 99(5):1065-1067. PMID: 33892856.
    Citations:    Fields:    
  2. Pandit A, Schlondorff J. Posaconazole-Induced Apparent Mineralocorticoid Excess. Kidney Int Rep. 2020 Dec; 5(12):2379-2382. PMID: 33305136.
  3. Feng D, Kumar M, Muntel J, Gurley SB, Birrane G, Stillman IE, Ding L, Wang M, Ahmed S, Schlondorff J, Alper SL, Ferrante T, Marquez SL, Ng CF, Novak R, Ingber DE, Steen H, Pollak MR. Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis. J Am Soc Nephrol. 2020 07; 31(7):1479-1495. PMID: 32540856.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  4. Stotter BR, Talbot BE, Capen DE, Artelt N, Zeng J, Matsumoto Y, Endlich N, Cummings RD, Schlondorff JS. Cosmc-dependent mucin-type O-linked glycosylation is essential for podocyte function. Am J Physiol Renal Physiol. 2020 02 01; 318(2):F518-F530. PMID: 31904283.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. Dvela-Levitt M, Kost-Alimova M, Emani M, Kohnert E, Thompson R, Sidhom EH, Rivadeneira A, Sahakian N, Roignot J, Papagregoriou G, Montesinos MS, Clark AR, McKinney D, Gutierrez J, Roth M, Ronco L, Elonga E, Carter TA, Gnirke A, Melanson M, Hartland K, Wieder N, Hsu JC, Deltas C, Hughey R, Bleyer AJ, Kmoch S, Živná M, Barešova V, Kota S, Schlondorff J, Heiman M, Alper SL, Wagner F, Weins A, Golub TR, Lander ES, Greka A. Small Molecule Targets TMED9 and Promotes Lysosomal Degradation to Reverse Proteinopathy. Cell. 2019 07 25; 178(3):521-535.e23. PMID: 31348885.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  6. Talbot BE, Vandorpe DH, Stotter BR, Alper SL, Schlondorff JS. Transmembrane insertases and N-glycosylation critically determine synthesis, trafficking, and activity of the nonselective cation channel TRPC6. J Biol Chem. 2019 08 23; 294(34):12655-12669. PMID: 31266804.
    Citations: 4     Fields:    Translation:HumansCells
  7. Poyan Mehr A, Sadeghi-Najafabadi M, Chau K, Messmer J, Pai R, Roy N, Friedman D, Pollak MR, Schlondorff J, Naljayan M, Singh T, Lecker SH, Rodby R, Germain M, Rennke H, Stillman IE. The Glomerular Disease Study and Trial Consortium: A Grassroots Initiative to Foster Collaboration and Innovation. Kidney Int Rep. 2019 Jan; 4(1):20-29. PMID: 30596165.
    Citations: 1     
  8. Schlondorff J. TRPC6 and kidney disease: sclerosing more than just glomeruli? Kidney Int. 2017 04; 91(4):773-775. PMID: 28314576.
    Citations: 7     Fields:    Translation:Humans
  9. Olabisi OA, Zhang JY, VerPlank L, Zahler N, DiBartolo S, Heneghan JF, Schlöndorff JS, Suh JH, Yan P, Alper SL, Friedman DJ, Pollak MR. APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):830-7. PMID: 26699492.
    Citations: 68     Fields:    Translation:HumansCells
  10. Schlondorff J. How many Achilles' heels does a podocyte have? An update on podocyte biology. Nephrol Dial Transplant. 2015 Jul; 30(7):1091-7. PMID: 24895439.
    Citations: 1     Fields:    
  11. Barua M, Shieh E, Schlondorff J, Genovese G, Kaplan BS, Pollak MR. Exome sequencing and in vitro studies identified podocalyxin as a candidate gene for focal and segmental glomerulosclerosis. Kidney Int. 2014 Jan; 85(1):124-33. PMID: 24048372.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  12. Chiluiza D, Krishna S, Schumacher VA, Schlöndorff J. Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2). J Biol Chem. 2013 Jun 21; 288(25):18407-20. PMID: 23645677.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  13. Sun H, Schlondorff J, Higgs HN, Pollak MR. Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling. J Am Soc Nephrol. 2013 May; 24(6):917-29. PMID: 23620398.
    Citations: 25     Fields:    Translation:HumansCells
  14. Carrasquillo R, Tian D, Krishna S, Pollak MR, Greka A, Schlöndorff J. SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity. BMC Cell Biol. 2012 Nov 21; 13:33. PMID: 23171048.
    Citations: 3     Fields:    Translation:HumansCells
  15. Cheong HI, Kang HG, Schlondorff J. GLCCI1 single nucleotide polymorphisms in pediatric nephrotic syndrome. Pediatr Nephrol. 2012 Sep; 27(9):1595-9. PMID: 22660954.
    Citations: 5     Fields:    Translation:Humans
  16. Sun H, Schlondorff JS, Brown EJ, Higgs HN, Pollak MR. Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2). Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2933-8. PMID: 21278336.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  17. Tian D, Jacobo SM, Billing D, Rozkalne A, Gage SD, Anagnostou T, Pavenstädt H, Pavenstaedt H, Hsu HH, Schlondorff J, Ramos A, Greka A. Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal. 2010 Oct 26; 3(145):ra77. PMID: 20978238.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  18. Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Tonna SJ, Uscinski AL, Higgs HN, Henderson JM, Pollak MR. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nat Genet. 2010 Jan; 42(1):72-6. PMID: 20023659.
    Citations: 200     Fields:    Translation:HumansCells
  19. Schlöndorff J, Del Camino D, Carrasquillo R, Lacey V, Pollak MR. TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT-dependent transcription. . 2009 Mar; 296(3):C558-69. PMID: 19129465.
    Citations: 66     Translation:HumansCells
  20. Schlondorff J. Nephrin AKTs on actin: The slit diaphragm-actin cytoskeleton signaling network expands. Kidney Int. 2008 Mar; 73(5):524-6. PMID: 18274541.
    Citations: 5     Fields:    Translation:AnimalsCells
  21. Tonna S, Dandapani SV, Uscinski A, Appel GB, Schlöndorff JS, Zhang K, Denker BM, Pollak MR. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). Gene. 2008 Feb 29; 410(1):44-52. PMID: 18206321.
    Citations: 2     Fields:    Translation:Humans
  22. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16080-5. PMID: 17901210.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  23. Schlondorff JS, Mendez GP, Rennke HG, Magee CC. Electrolyte abnormalities and progressive renal failure in a cancer patient. Kidney Int. 2007 Jun; 71(11):1181-4. PMID: 17332730.
    Citations:    Fields:    Translation:Humans
  24. Schlöndorff JS, Pollak MR. TRPC6 in glomerular health and disease: what we know and what we believe. Semin Cell Dev Biol. 2006 Dec; 17(6):667-74. PMID: 17116414.
    Citations: 14     Fields:    Translation:HumansAnimals
  25. Weskamp G, Schlöndorff J, Lum L, Becherer JD, Kim TW, Saftig P, Hartmann D, Murphy G, Blobel CP. Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J Biol Chem. 2004 Feb 06; 279(6):4241-9. PMID: 14638693.
    Citations: 46     Fields:    Translation:AnimalsCells
  26. Zheng Y, Schlondorff J, Blobel CP. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem. 2002 Nov 08; 277(45):42463-70. PMID: 12207026.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  27. Schlöndorff J, Lum L, Blobel CP. Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase. J Biol Chem. 2001 May 04; 276(18):14665-74. PMID: 11278735.
    Citations: 31     Fields:    Translation:AnimalsCells
  28. Schlöndorff J, Becherer JD, Blobel CP. Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE). Biochem J. 2000 Apr 01; 347 Pt 1:131-8. PMID: 10727411.
    Citations: 101     Fields:    Translation:HumansAnimalsCells
  29. Schlöndorff J, Blobel CP. Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci. 1999 Nov; 112 ( Pt 21):3603-17. PMID: 10523497.
    Citations: 118     Fields:    Translation:AnimalsCells
  30. Nelson KK, Schlöndorff J, Blobel CP. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. Biochem J. 1999 Nov 01; 343 Pt 3:673-80. PMID: 10527948.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  31. Lum L, Wong BR, Josien R, Becherer JD, Erdjument-Bromage H, Schlöndorff J, Tempst P, Choi Y, Blobel CP. Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J Biol Chem. 1999 May 07; 274(19):13613-8. PMID: 10224132.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  32. Kaestner KH, Bleckmann SC, Monaghan AP, Schlöndorff J, Mincheva A, Lichter P, Schütz G. Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. Development. 1996 Jun; 122(6):1751-8. PMID: 8674414.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  33. Kaestner KH, Lee KH, Schlöndorff J, Hiemisch H, Monaghan AP, Schütz G. Six members of the mouse forkhead gene family are developmentally regulated. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7628-31. PMID: 7689224.
    Citations: 34     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.