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profileJohannes Schlondorff, M.D., Ph.D.

TitleAssistant Professor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Medical Center
Research North 304B, Div. of Nephrology
99 Brookline Ave
Boston MA 02215
Phone6176670508
Fax6176670495
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
K08DK080947     (SCHLONDORFF, JOHANNES S)Sep 30, 2008 - Sep 30, 2013
NIH/NIDDK
TRPC6 Regulation and its Role in Glomerular Pathology
Role: Principal Investigator

F32DK074308     (SCHLONDORFF, JOHANNES S)Jun 30, 2006 - Jun 29, 2008
NIH/NIDDK
Characterization of TRPC6 mutations in inherited FSGS
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Olabisi OA, Zhang JY, VerPlank L, Zahler N, DiBartolo S, Heneghan JF, Schlöndorff JS, Suh JH, Yan P, Alper SL, Friedman DJ, Pollak MR. APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. Proc Natl Acad Sci U S A. 2016 Jan 26; 113(4):830-7. PMID: 26699492; PMCID: PMC4743809.
  2. Schlondorff J. How many Achilles' heels does a podocyte have? An update on podocyte biology. Nephrol Dial Transplant. 2015 Jul; 30(7):1091-7. PMID: 24895439.
    View in: PubMed
  3. Barua M, Shieh E, Schlondorff J, Genovese G, Kaplan BS, Pollak MR. Exome sequencing and in vitro studies identified podocalyxin as a candidate gene for focal and segmental glomerulosclerosis. Kidney Int. 2014 Jan; 85(1):124-33. PMID: 24048372; PMCID: PMC4068013.
  4. Chiluiza D, Krishna S, Schumacher VA, Schlöndorff J. Gain-of-function mutations in transient receptor potential C6 (TRPC6) activate extracellular signal-regulated kinases 1/2 (ERK1/2). J Biol Chem. 2013 Jun 21; 288(25):18407-20. PMID: 23645677; PMCID: PMC3689983.
  5. Sun H, Schlondorff J, Higgs HN, Pollak MR. Inverted formin 2 regulates actin dynamics by antagonizing Rho/diaphanous-related formin signaling. J Am Soc Nephrol. 2013 May; 24(6):917-29. PMID: 23620398; PMCID: PMC3665394.
  6. Carrasquillo R, Tian D, Krishna S, Pollak MR, Greka A, Schlöndorff J. SNF8, a member of the ESCRT-II complex, interacts with TRPC6 and enhances its channel activity. BMC Cell Biol. 2012 Nov 21; 13:33. PMID: 23171048; PMCID: PMC3520717.
  7. Cheong HI, Kang HG, Schlondorff J. GLCCI1 single nucleotide polymorphisms in pediatric nephrotic syndrome. Pediatr Nephrol. 2012 Sep; 27(9):1595-9. PMID: 22660954; PMCID: PMC3408784.
  8. Sun H, Schlondorff JS, Brown EJ, Higgs HN, Pollak MR. Rho activation of mDia formins is modulated by an interaction with inverted formin 2 (INF2). Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2933-8. PMID: 21278336; PMCID: PMC3041098.
  9. Tian D, Jacobo SM, Billing D, Rozkalne A, Gage SD, Anagnostou T, Pavenstädt H, Pavenstaedt H, Hsu HH, Schlondorff J, Ramos A, Greka A. Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal. 2010 Oct 26; 3(145):ra77. PMID: 20978238; PMCID: PMC3071756.
  10. Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Tonna SJ, Uscinski AL, Higgs HN, Henderson JM, Pollak MR. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis. Nat Genet. 2010 Jan; 42(1):72-6. PMID: 20023659; PMCID: PMC2980844.
  11. Schlöndorff J, del Camino D, Carrasquillo R, Lacey V, Pollak MR. TRPC6 mutations associated with focal segmental glomerulosclerosis cause constitutive activation of NFAT and CREB dependent transcription. American Journal of Physiology - Cell Physiology (In press). 2009.
  12. Schlondorff J. Nephrin AKTs on actin: The slit diaphragm-actin cytoskeleton signaling network expands. Kidney Int. 2008 Mar; 73(5):524-6. PMID: 18274541.
    View in: PubMed
  13. Tonna S, Dandapani SV, Uscinski A, Appel GB, Schlöndorff JS, Zhang K, Denker BM, Pollak MR. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). Gene. 2008 Feb 29; 410(1):44-52. PMID: 18206321; PMCID: PMC2705935.
  14. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16080-5. PMID: 17901210; PMCID: PMC2042165.
  15. Schlondorff JS, Mendez GP, Rennke HG, Magee CC. Electrolyte abnormalities and progressive renal failure in a cancer patient. Kidney Int. 2007 Jun; 71(11):1181-4. PMID: 17332730.
    View in: PubMed
  16. Schlöndorff JS, Pollak MR. TRPC6 in glomerular health and disease: what we know and what we believe. Semin Cell Dev Biol. 2006 Dec; 17(6):667-74. PMID: 17116414; PMCID: PMC2705932.
  17. Weskamp G, Schlöndorff J, Lum L, Becherer JD, Kim TW, Saftig P, Hartmann D, Murphy G, Blobel CP. Evidence for a critical role of the tumor necrosis factor alpha convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR). J Biol Chem. 2004 Feb 06; 279(6):4241-9. PMID: 14638693.
    View in: PubMed
  18. Zheng Y, Schlondorff J, Blobel CP. Evidence for regulation of the tumor necrosis factor alpha-convertase (TACE) by protein-tyrosine phosphatase PTPH1. J Biol Chem. 2002 Nov 08; 277(45):42463-70. PMID: 12207026.
    View in: PubMed
  19. Schlöndorff J, Lum L, Blobel CP. Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase. J Biol Chem. 2001 May 04; 276(18):14665-74. PMID: 11278735.
    View in: PubMed
  20. Schlöndorff J, Becherer JD, Blobel CP. Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE). Biochem J. 2000 Apr 01; 347 Pt 1:131-8. PMID: 10727411; PMCID: PMC1220940.
  21. Schlöndorff J, Blobel CP. Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding. J Cell Sci. 1999 Nov; 112 ( Pt 21):3603-17. PMID: 10523497.
    View in: PubMed
  22. Nelson KK, Schlöndorff J, Blobel CP. Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta. Biochem J. 1999 Nov 01; 343 Pt 3:673-80. PMID: 10527948; PMCID: PMC1220601.
  23. Lum L, Wong BR, Josien R, Becherer JD, Erdjument-Bromage H, Schlöndorff J, Tempst P, Choi Y, Blobel CP. Evidence for a role of a tumor necrosis factor-alpha (TNF-alpha)-converting enzyme-like protease in shedding of TRANCE, a TNF family member involved in osteoclastogenesis and dendritic cell survival. J Biol Chem. 1999 May 07; 274(19):13613-8. PMID: 10224132.
    View in: PubMed
  24. Kaestner KH, Bleckmann SC, Monaghan AP, Schlöndorff J, Mincheva A, Lichter P, Schütz G. Clustered arrangement of winged helix genes fkh-6 and MFH-1: possible implications for mesoderm development. Development. 1996 Jun; 122(6):1751-8. PMID: 8674414.
    View in: PubMed
  25. Kaestner KH, Lee KH, Schlöndorff J, Hiemisch H, Monaghan AP, Schütz G. Six members of the mouse forkhead gene family are developmentally regulated. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7628-31. PMID: 7689224; PMCID: PMC47195.
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