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Karen Inouye, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamisligil GS. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. 2022 03; 603(7902):736-742. PMID: 35264794; PMCID: PMC9014868.
    Citations: 2     Fields:    Translation:AnimalsCells
  2. Guney E, Arruda AP, Parlakgul G, Cagampan E, Min N, Lee GY, Greene L, Tsaousidou E, Inouye K, Han MS, Davis RJ, Hotamisligil GS. Aberrant Ca2+ signaling by IP3Rs in adipocytes links inflammation to metabolic dysregulation in obesity. Sci Signal. 2021 Dec 14; 14(713):eabf2059. PMID: 34905386.
    Citations:    Fields:    Translation:HumansCells
  3. Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS. A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature. 2021 12; 600(7890):720-726. PMID: 34880500; PMCID: PMC8983123.
    Citations: 3     Fields:    Translation:HumansCells
  4. Liu CL, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J, Shi GP. Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice. Eur Heart J. 2020 07 07; 41(26):2456-2468. PMID: 31821481; PMCID: PMC8453281.
    Citations: 15     Fields:    Translation:AnimalsCells
  5. Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS. The short-chain fatty acid propionate increases glucagon and FABP4 production, impairing insulin action in mice and humans. Sci Transl Med. 2019 04 24; 11(489). PMID: 31019023.
    Citations: 57     Fields:    Translation:HumansAnimals
  6. Liu L, Inouye KE, Allman WR, Coleman AS, Siddiqui S, Hotamisligil GS, Akkoyunlu M. TACI-Deficient Macrophages Protect Mice Against Metaflammation and Obesity-Induced Dysregulation of Glucose Homeostasis. Diabetes. 2018 08; 67(8):1589-1603. PMID: 29871859; PMCID: PMC6054430.
    Citations: 8     Fields:    Translation:AnimalsCells
  7. Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med. 2018 03; 24(3):292-303. PMID: 29400713; PMCID: PMC5839993.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  8. Charles KN, Li MD, Engin F, Arruda AP, Inouye K, Hotamisligil GS. Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins. Cell Rep. 2017 Oct 10; 21(2):393-402. PMID: 29020626.
    Citations: 15     Fields:    Translation:Animals
  9. Brace LE, Vose SC, Stanya K, Gathungu RM, Marur VR, Longchamp A, Treviño-Villarreal H, Mejia P, Vargas D, Inouye K, Bronson RT, Lee CH, Neilan E, Kristal BS, Mitchell JR. Increased oxidative phosphorylation in response to acute and chronic DNA damage. NPJ Aging Mech Dis. 2016; 2:16022. PMID: 28721274; PMCID: PMC5514997.
    Citations: 29     
  10. Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci Transl Med. 2015 Dec 23; 7(319):319ra205. PMID: 26702093.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  11. Lee YJ, Liu C, Liao M, Sukhova GK, Shirakawa J, Abdennour M, Iamarene K, Andre S, Inouye K, Clement K, Kulkarni RN, Banks AS, Libby P, Shi GP. Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015 Nov; 156(11):4047-58. PMID: 26295369; PMCID: PMC4606759.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Arruda AP, Pers BM, Parlakgül G, Güney E, Inouye K, Hotamisligil GS. Chronic enrichment of hepatic endoplasmic reticulum-mitochondria contact leads to mitochondrial dysfunction in obesity. Nat Med. 2014 Dec; 20(12):1427-35. PMID: 25419710.
    Citations: 212     Fields:    Translation:AnimalsCells
  13. Liu S, Brown JD, Stanya KJ, Homan E, Leidl M, Inouye K, Bhargava P, Gangl MR, Dai L, Hatano B, Hotamisligil GS, Saghatelian A, Plutzky J, Lee CH. A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use. Nature. 2013 Oct 24; 502(7472):550-4. PMID: 24153306.
    Citations: 101     Fields:    Translation:AnimalsCells
  14. Cao H, Sekiya M, Ertunc ME, Burak MF, Mayers JR, White A, Inouye K, Rickey LM, Ercal BC, Furuhashi M, Tuncman G, Hotamisligil GS. Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production. Cell Metab. 2013 May 07; 17(5):768-78. PMID: 23663740.
    Citations: 102     Fields:    Translation:AnimalsCells
  15. Gregor MF, Misch ES, Yang L, Hummasti S, Inouye KE, Lee AH, Bierie B, Hotamisligil GS. The role of adipocyte XBP1 in metabolic regulation during lactation. Cell Rep. 2013 May 30; 3(5):1430-9. PMID: 23623498.
    Citations: 28     Fields:    Translation:AnimalsCells
  16. Stanya KJ, Jacobi D, Liu S, Bhargava P, Dai L, Gangl MR, Inouye K, Barlow JL, Ji Y, Mizgerd JP, Qi L, Shi H, McKenzie AN, Lee CH. Direct control of hepatic glucose production by interleukin-13 in mice. J Clin Invest. 2013 Jan; 123(1):261-71. PMID: 23257358; PMCID: PMC3533296.
    Citations: 59     Fields:    Translation:AnimalsCells
  17. Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 30; 488(7413):670-4. PMID: 22801494; PMCID: PMC4163918.
    Citations: 335     Fields:    Translation:HumansAnimalsCells
  18. Inouye KE, Chan O, Yue JT, Andrews M, Li Q, Matthews SG, Vranic M. The effect of long-term insulin treatment with and without antecedent hypoglycemia on neuropeptide and corticosteroid receptor expression in the brains of diabetic rats. Brain Res Bull. 2008 Oct 22; 77(4):149-57. PMID: 18672033.
    Citations: 5     Fields:    Translation:Animals
  19. Inouye KE, Shi H, Howard JK, Daly CH, Lord GM, Rollins BJ, Flier JS. Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue. Diabetes. 2007 Sep; 56(9):2242-50. PMID: 17473219.
    Citations: 105     Fields:    Translation:AnimalsCells
  20. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest. 2006 Nov; 116(11):3015-25. PMID: 17053832; PMCID: PMC1616196.
    Citations: 1371     Fields:    Translation:HumansAnimalsCells
  21. Shi H, Cave B, Inouye K, Bjørbaek C, Flier JS. Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes. 2006 Mar; 55(3):699-707. PMID: 16505233.
    Citations: 41     Fields:    Translation:AnimalsCells
  22. Inouye KE, Yue JT, Chan O, Kim T, Akirav EM, Park E, Riddell MC, Burdett E, Matthews SG, Vranic M. Effects of insulin treatment without and with recurrent hypoglycemia on hypoglycemic counterregulation and adrenal catecholamine-synthesizing enzymes in diabetic rats. Endocrinology. 2006 Apr; 147(4):1860-70. PMID: 16396986.
    Citations: 7     Fields:    Translation:Animals
  23. Chan O, Inouye K, Akirav EM, Park E, Riddell MC, Matthews SG, Vranic M. Hyperglycemia does not increase basal hypothalamo-pituitary-adrenal activity in diabetes but it does impair the HPA response to insulin-induced hypoglycemia. Am J Physiol Regul Integr Comp Physiol. 2005 Jul; 289(1):R235-46. PMID: 15774766.
    Citations: 15     Fields:    Translation:Animals
  24. Akirav EM, Chan O, Inouye K, Riddell MC, Matthews SG, Vranic M. Partial leptin restoration increases hypothalamic-pituitary-adrenal activity while diminishing weight loss and hyperphagia in streptozotocin diabetic rats. Metabolism. 2004 Dec; 53(12):1558-64. PMID: 15562400.
    Citations: 4     Fields:    Translation:Animals
  25. Chan O, Inouye K, Akirav E, Park E, Riddell MC, Vranic M, Matthews SG. Insulin alone increases hypothalamo-pituitary-adrenal activity, and diabetes lowers peak stress responses. Endocrinology. 2005 Mar; 146(3):1382-90. PMID: 15564337.
    Citations: 20     Fields:    Translation:Animals
  26. Inouye KE, Chan O, Yue JT, Matthews SG, Vranic M. Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis. Am J Physiol Endocrinol Metab. 2005 Feb; 288(2):E422-9. PMID: 15494609.
    Citations: 6     Fields:    Translation:Animals
  27. Chan O, Inouye K, Riddell MC, Vranic M, Matthews SG. Diabetes and the hypothalamo-pituitary-adrenal (HPA) axis. Minerva Endocrinol. 2003 Jun; 28(2):87-102. PMID: 12717340.
    Citations: 36     Fields:    Translation:Humans
  28. Inouye K, Chan O, Riddell MC, Akirav E, Matthews SG, Vranic M. Mechanisms of impaired hypothalamic-pituitary-adrenal (HPA) function in diabetes: reduced counterregulatory responsiveness to hypoglycaemia. Diabetes Nutr Metab. 2002 Oct; 15(5):348-55; discussion 355-6, 362. PMID: 12625483.
    Citations: 5     Fields:    Translation:HumansAnimals
  29. Chan O, Chan S, Inouye K, Shum K, Matthews SG, Vranic M. Diabetes impairs hypothalamo-pituitary-adrenal (HPA) responses to hypoglycemia, and insulin treatment normalizes HPA but not epinephrine responses. Diabetes. 2002 Jun; 51(6):1681-9. PMID: 12031953.
    Citations: 20     Fields:    Translation:Animals
  30. Inouye K, Shum K, Chan O, Mathoo J, Matthews SG, Vranic M. Effects of recurrent hyperinsulinemia with and without hypoglycemia on counterregulation in diabetic rats. Am J Physiol Endocrinol Metab. 2002 Jun; 282(6):E1369-79. PMID: 12006368.
    Citations: 11     Fields:    Translation:Animals
  31. Chan O, Inouye K, Vranic M, Matthews SG. Hyperactivation of the hypothalamo-pituitary-adrenocortical axis in streptozotocin-diabetes is associated with reduced stress responsiveness and decreased pituitary and adrenal sensitivity. Endocrinology. 2002 May; 143(5):1761-8. PMID: 11956158.
    Citations: 22     Fields:    Translation:Animals
  32. Chan O, Chan S, Inouye K, Vranic M, Matthews SG. Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment. Endocrinology. 2001 Nov; 142(11):4872-9. PMID: 11606455.
    Citations: 16     Fields:    Translation:Animals
  33. Shum K, Inouye K, Chan O, Mathoo J, Bilinski D, Matthews SG, Vranic M. Effects of antecedent hypoglycemia, hyperinsulinemia, and excess corticosterone on hypoglycemic counterregulation. Am J Physiol Endocrinol Metab. 2001 Sep; 281(3):E455-65. PMID: 11500300.
    Citations: 13     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.