Harvard Catalyst Profiles

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Bradley Mark Denker, M.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50DK074030 (ZHOU, JING) Sep 30, 2005 - Aug 31, 2011
    Harvard Center of Polycystic Kidney Disease Research
    Role: Co-Principal Investigator
  2. R21DK065932 (DENKER, BRADLEY M) Feb 1, 2004 - Jan 31, 2006
    G Protein Regulation of Glomerular Epithelial Cells
    Role: Principal Investigator
  3. R01GM055223 (DENKER, BRADLEY M) Jul 1, 1997 - May 31, 2012
    Attachment, Targeting and Localization of Galpha Subunits
    Role: Principal Investigator
  4. R29GM055223 (DENKER, BRADLEY M) Jul 1, 1997 - Jun 30, 2002
    Role: Principal Investigator
  5. K08DK002110 (DENKER, BRADLEY M) Jul 1, 1992 - Jun 30, 1997
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Morales-Alvarez MC, Knob A, Rennke HG, Pollak MR, Denker BM. Clinical and Pathological Heterogeneity in FSGS due to INF2 Mutations. Kidney Int Rep. 2022 Dec; 7(12):2741-2745. PMID: 36506246; PMCID: PMC9727514.
  2. Pandit AP, Rennke HG, Denker BM. Podocytic Infolding Glomerulopathy in a Patient with Phospholipase A2 Receptor-Positive Membranous Nephropathy and Review of the Literature. Nephron. 2021; 145(5):496-502. PMID: 33965947.
    Citations:    Fields:    Translation:HumansCells
  3. Agarwal KA, Heher YK, Denker BM. Drug-Induced Thrombotic Microangiopathy Resulting in ESRD. Kidney Int Rep. 2020 Aug; 5(8):1350-1355. PMID: 32775839; PMCID: PMC7403540.
  4. Tutunea-Fatan E, Lee JC, Denker BM, Gunaratnam L. Heterotrimeric Ga12/13 proteins in kidney injury and disease. Am J Physiol Renal Physiol. 2020 03 01; 318(3):F660-F672. PMID: 31984793.
    Citations: 2     Fields:    Translation:Humans
  5. Drury ER, Stillman IE, Pollak MR, Denker BM. Autosomal Recessive Alport Syndrome Unveiled by Pregnancy. Nephron. 2019; 143(4):288-292. PMID: 31408864.
    Citations: 3     Fields:    Translation:Humans
  6. Sequist TD, Holliday AM, Orav EJ, Bates DW, Denker BM. Physician and patient tools to improve chronic kidney disease care. Am J Manag Care. 2018 04 01; 24(4):e107-e114. PMID: 29668213.
    Citations: 6     Fields:    Translation:Humans
  7. Wu Y, Xu JX, El-Jouni W, Lu T, Li S, Wang Q, Tran M, Yu W, Wu M, Barrera IE, Bonventre JV, Zhou J, Denker BM, Kong T. Ga12 is required for renal cystogenesis induced by Pkd1 inactivation. J Cell Sci. 2016 10 01; 129(19):3675-3684. PMID: 27505895; PMCID: PMC5087651.
    Citations: 9     Fields:    Translation:AnimalsCells
  8. Ismail OZ, Zhang X, Wei J, Haig A, Denker BM, Suri RS, Sener A, Gunaratnam L. Kidney injury molecule-1 protects against Ga12 activation and tissue damage in renal ischemia-reperfusion injury. Am J Pathol. 2015 May; 185(5):1207-15. PMID: 25759266; PMCID: PMC4419204.
    Citations: 22     Fields:    Translation:Animals
  9. Xu JX, Lu TS, Li S, Wu Y, Ding L, Denker BM, Bonventre JV, Kong T. Polycystin-1 and Ga12 regulate the cleavage of E-cadherin in kidney epithelial cells. Physiol Genomics. 2015 Feb; 47(2):24-32. PMID: 25492927; PMCID: PMC4313070.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  10. Barski JJ, Denker BM, Guan J, Lauth M, Spreafico F, Fertala A, Meyer M. Developmental upregulation of an alternative form of pcp2 with reduced GDI activity. Cerebellum. 2014 Apr; 13(2):207-14. PMID: 24092530.
    Citations: 2     Fields:    Translation:AnimalsCells
  11. Yu W, Beaudry S, Negoro H, Boucher I, Tran M, Kong T, Denker BM. H2O2 activates G protein, a 12 to disrupt the junctional complex and enhance ischemia reperfusion injury. Proc Natl Acad Sci U S A. 2012 Apr 24; 109(17):6680-5. PMID: 22493269.
    Citations: 28     Fields:    Translation:AnimalsCells
  12. Boucher I, Yu W, Beaudry S, Negoro H, Tran M, Pollak MR, Henderson JM, Denker BM. Ga12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis. Lab Invest. 2012 May; 92(5):662-75. PMID: 22249312.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  13. Denker B, Robles-Osorio ML, Sabath E. Recent advances in diagnosis and treatment of acute kidney injury in patients with cancer. Eur J Intern Med. 2011 Aug; 22(4):348-54. PMID: 21767751.
    Citations: 6     Fields:    Translation:Humans
  14. Denker BM, Sabath E. The biology of epithelial cell tight junctions in the kidney. J Am Soc Nephrol. 2011 Apr; 22(4):622-5. PMID: 21415157.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  15. Dowal L, Sim DS, Dilks JR, Blair P, Beaudry S, Denker BM, Koukos G, Kuliopulos A, Flaumenhaft R. Identification of an antithrombotic allosteric modulator that acts through helix 8 of PAR1. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2951-6. PMID: 21282664.
    Citations: 34     Fields:    Translation:AnimalsCells
  16. Allen AS, Forman JP, Orav EJ, Bates DW, Denker BM, Sequist TD. Primary care management of chronic kidney disease. J Gen Intern Med. 2011 Apr; 26(4):386-92. PMID: 20922494.
    Citations: 72     Fields:    Translation:Humans
  17. Yu W, Ritchie BJ, Su X, Zhou J, Meigs TE, Denker BM. Identification of polycystin-1 and Ga12 binding regions necessary for regulation of apoptosis. Cell Signal. 2011 Jan; 23(1):213-21. PMID: 20837139.
    Citations: 13     Fields:    Translation:HumansCells
  18. Kong T, Xu D, Tran M, Denker BM. Regulation of integrin expression by Ga12: An additional potential mechanism modulating cell attachment. Cell Adh Migr. 2010 Jul-Sep; 4(3):372-6. PMID: 20424510.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  19. Yu W, Kong T, Beaudry S, Tran M, Negoro H, Yanamadala V, Denker BM. Polycystin-1 protein level determines activity of the Galpha12/JNK apoptosis pathway. J Biol Chem. 2010 Apr 02; 285(14):10243-51. PMID: 20106977.
    Citations: 23     Fields:    Translation:AnimalsCells
  20. Kong T, Xu D, Yu W, Takakura A, Boucher I, Tran M, Kreidberg JA, Shah J, Zhou J, Denker BM. G alpha 12 inhibits alpha2 beta1 integrin-mediated Madin-Darby canine kidney cell attachment and migration on collagen-I and blocks tubulogenesis. Mol Biol Cell. 2009 Nov; 20(21):4596-610. PMID: 19776354.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  21. Yanamadala V, Negoro H, Denker BM. Heterotrimeric G proteins and apoptosis: intersecting signaling pathways leading to context dependent phenotypes. Curr Mol Med. 2009 Jun; 9(5):527-45. PMID: 19601805.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  22. Sabath E, Negoro H, Beaudry S, Paniagua M, Angelow S, Shah J, Grammatikakis N, Yu AS, Denker BM. Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly. J Cell Sci. 2008 Mar 15; 121(Pt 6):814-24. PMID: 18285450.
    Citations: 33     Fields:    Translation:AnimalsCells
  23. Tonna S, Dandapani SV, Uscinski A, Appel GB, Schlöndorff JS, Zhang K, Denker BM, Pollak MR. Functional genetic variation in aminopeptidase A (ENPEP): lack of clear association with focal and segmental glomerulosclerosis (FSGS). Gene. 2008 Feb 29; 410(1):44-52. PMID: 18206321.
    Citations: 2     Fields:    Translation:Humans
  24. Weins A, Schlondorff JS, Nakamura F, Denker BM, Hartwig JH, Stossel TP, Pollak MR. Disease-associated mutant alpha-actinin-4 reveals a mechanism for regulating its F-actin-binding affinity. Proc Natl Acad Sci U S A. 2007 Oct 09; 104(41):16080-5. PMID: 17901210.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  25. Yanamadala V, Negoro H, Gunaratnam L, Kong T, Denker BM. Galpha12 stimulates apoptosis in epithelial cells through JNK1-mediated Bcl-2 degradation and up-regulation of IkappaBalpha. J Biol Chem. 2007 Aug 17; 282(33):24352-63. PMID: 17565996.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  26. Zhu D, Tate RI, Ruediger R, Meigs TE, Denker BM. Domains necessary for Galpha12 binding and stimulation of protein phosphatase-2A (PP2A): Is Galpha12 a novel regulatory subunit of PP2A? Mol Pharmacol. 2007 May; 71(5):1268-76. PMID: 17303700.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  27. Sabath E, Denker BM. Cell-cell interactions in the kidney: inducible expression of mutant G protein alpha-subunits in Madin-Darby canine kidney cells for studies of epithelial cell junction structure and function. Methods Mol Biol. 2006; 341:61-72. PMID: 16799189.
    Citations: 2     Fields:    Translation:AnimalsCells
  28. Guan J, Luo Y, Denker BM. Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gbetagamma-mediated activation of Ras and p38 MAPK. Biochem J. 2005 Dec 01; 392(Pt 2):389-97. PMID: 15948714; PMCID: PMC1316275.
    Citations: 16     Fields:    Translation:AnimalsCells
  29. Hunt JL, Pollak MR, Denker BM. Cultured podocytes establish a size-selective barrier regulated by specific signaling pathways and demonstrate synchronized barrier assembly in a calcium switch model of junction formation. J Am Soc Nephrol. 2005 Jun; 16(6):1593-602. PMID: 15843471.
    Citations: 16     Fields:    Translation:AnimalsCells
  30. Zhu D, Kosik KS, Meigs TE, Yanamadala V, Denker BM. Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau. J Biol Chem. 2004 Dec 31; 279(53):54983-6. PMID: 15525651.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  31. Yuasa T, Takakura A, Denker BM, Venugopal B, Zhou J. Polycystin-1L2 is a novel G-protein-binding protein. Genomics. 2004 Jul; 84(1):126-38. PMID: 15203210.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  32. Yao J, Le TC, Kos CH, Henderson JM, Allen PG, Denker BM, Pollak MR. Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein. PLoS Biol. 2004 Jun; 2(6):e167. PMID: 15208719; PMCID: PMC423141.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  33. Meyer TN, Hunt J, Schwesinger C, Denker BM. Galpha12 regulates epithelial cell junctions through Src tyrosine kinases. Am J Physiol Cell Physiol. 2003 Nov; 285(5):C1281-93. PMID: 12890651.
    Citations: 22     Fields:    Translation:AnimalsCells
  34. Redd KJ, Oberdick J, McCoy J, Denker BM, Luo Y. Association and colocalization of G protein alpha subunits and Purkinje cell protein 2 (Pcp2) in mammalian cerebellum. J Neurosci Res. 2002 Dec 01; 70(5):631-7. PMID: 12424730.
    Citations: 5     Fields:    Translation:AnimalsCells
  35. Meyer TN, Schwesinger C, Denker BM. Zonula occludens-1 is a scaffolding protein for signaling molecules. Galpha(12) directly binds to the Src homology 3 domain and regulates paracellular permeability in epithelial cells. J Biol Chem. 2002 Jul 12; 277(28):24855-8. PMID: 12023272.
    Citations: 40     Fields:    Translation:AnimalsCells
  36. Saha C, Nigam SK, Denker BM. Expanding role of G proteins in tight junction regulation: Galpha(s) stimulates TJ assembly. Biochem Biophys Res Commun. 2001 Jul 13; 285(2):250-6. PMID: 11444833.
    Citations: 5     Fields:    Translation:AnimalsCells
  37. Meyer TN, Schwesinger C, Ye J, Denker BM, Nigam SK. Reassembly of the tight junction after oxidative stress depends on tyrosine kinase activity. J Biol Chem. 2001 Jun 22; 276(25):22048-55. PMID: 11294856.
    Citations: 37     Fields:    Translation:AnimalsCells
  38. Busconi L, Guan J, Denker BM. Degradation of heterotrimeric Galpha(o) subunits via the proteosome pathway is induced by the hsp90-specific compound geldanamycin. J Biol Chem. 2000 Jan 21; 275(3):1565-9. PMID: 10636845.
    Citations: 10     Fields:    Translation:AnimalsCells
  39. Luo Y, Denker BM. Interaction of heterotrimeric G protein Galphao with Purkinje cell protein-2. Evidence for a novel nucleotide exchange factor. J Biol Chem. 1999 Apr 16; 274(16):10685-8. PMID: 10196137.
    Citations: 21     Fields:    Translation:AnimalsCells
  40. Saha C, Nigam SK, Denker BM. Involvement of Galphai2 in the maintenance and biogenesis of epithelial cell tight junctions. J Biol Chem. 1998 Aug 21; 273(34):21629-33. PMID: 9705295.
    Citations: 18     Fields:    Translation:AnimalsCells
  41. Denker BM, Nigam SK. Molecular structure and assembly of the tight junction. Am J Physiol. 1998 01; 274(1):F1-9. PMID: 9458817.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  42. Busconi L, Denker BM. Analysis of the N-terminal binding domain of Go alpha. Biochem J. 1997 Nov 15; 328 ( Pt 1):23-31. PMID: 9359829; PMCID: PMC1218882.
    Citations: 2     Fields:    Translation:AnimalsCells
  43. Busconi L, Boutin PM, Denker BM. N-terminal binding domain of Galpha subunits: involvement of amino acids 11-14 of Galphao in membrane attachment. Biochem J. 1997 Apr 01; 323 ( Pt 1):239-44. PMID: 9173888; PMCID: PMC1218301.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Denker BM, Saha C, Khawaja S, Nigam SK. Involvement of a heterotrimeric G protein alpha subunit in tight junction biogenesis. J Biol Chem. 1996 Oct 18; 271(42):25750-3. PMID: 8824202.
    Citations: 27     Fields:    Translation:AnimalsCells
  45. Denker BM, Boutin PM, Neer EJ. Interactions between the amino- and carboxyl-terminal regions of G alpha subunits: analysis of mutated G alpha o/G alpha i2 chimeras. Biochemistry. 1995 Apr 25; 34(16):5544-53. PMID: 7727415.
    Citations: 8     Fields:    Translation:AnimalsCells
  46. Neer EJ, Denker BM, Thomas TC, Schmidt CJ. Analysis of G-protein alpha and beta gamma subunits by in vitro translation. Methods Enzymol. 1994; 237:226-39. PMID: 7934999.
    Citations: 6     Fields:    Translation:AnimalsCells
  47. Denker BM, Schmidt CJ, Neer EJ. Promotion of the GTP-liganded state of the Go alpha protein by deletion of the C terminus. J Biol Chem. 1992 May 15; 267(14):9998-10002. PMID: 1577829.
    Citations: 15     Fields:    Translation:AnimalsCells
  48. Denker BM, Neer EJ, Schmidt CJ. Mutagenesis of the amino terminus of the alpha subunit of the G protein Go. In vitro characterization of alpha o beta gamma interactions. J Biol Chem. 1992 Mar 25; 267(9):6272-7. PMID: 1556134.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  49. Denker BM, Tempst P, Neer EJ. Characterization of a mastoparan-stimulated nucleotidase from bovine brain. Biochem J. 1991 Sep 01; 278 ( Pt 2):341-5. PMID: 1654878; PMCID: PMC1151346.
    Citations: 3     Fields:    Translation:AnimalsCells
  50. Yi F, Denker BM, Neer EJ. Structural and functional studies of cross-linked Go protein subunits. J Biol Chem. 1991 Feb 25; 266(6):3900-6. PMID: 1899868.
    Citations: 10     Fields:    Translation:AnimalsCells
  51. Denker BM, Neer EJ. GO associates with another 40 kDa brain protein. FEBS Lett. 1991 Feb 11; 279(1):98-100. PMID: 1899838.
    Citations: 3     Fields:    Translation:Animals
  52. Saboori AM, Denker BM, Agre P. Isolation of proteins related to the Rh polypeptides from nonhuman erythrocytes. J Clin Invest. 1989 Jan; 83(1):187-91. PMID: 2492035; PMCID: PMC303660.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  53. Denker BM, Smith BL, Kuhajda FP, Agre P. Identification, purification, and partial characterization of a novel Mr 28,000 integral membrane protein from erythrocytes and renal tubules. J Biol Chem. 1988 Oct 25; 263(30):15634-42. PMID: 3049610.
    Citations: 157     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.