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Alice E Chen, Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Beilmann M, Boonen H, Czich A, Dear G, Hewitt P, Mow T, Newham P, Oinonen T, Pognan F, Roth A, Valentin JP, Van Goethem F, Weaver RJ, Birk B, Boyer S, Caloni F, Chen AE, Corvi R, Cronin MTD, Daneshian M, Ewart LC, Fitzgerald RE, Hamilton GA, Hartung T, Kangas JD, Kramer NI, Leist M, Marx U, Polak S, Rovida C, Testai E, Van der Water B, Vulto P, Steger-Hartmann T. Optimizing drug discovery by Investigative Toxicology: Current and future trends. ALTEX. 2019; 36(2):289-313. PMID: 30570669.
    Citations:    Fields:    
  2. King SM, Higgins JW, Nino CR, Smith TR, Paffenroth EH, Fairbairn CE, Docuyanan A, Shah VD, Chen AE, Presnell SC, Nguyen DG. 3D Proximal Tubule Tissues Recapitulate Key Aspects of Renal Physiology to Enable Nephrotoxicity Testing. Front Physiol. 2017; 8:123. PMID: 28337147.
    Citations: 3     
  3. Hardwick RN, Viergever C, Chen AE, Nguyen DG. 3D bioengineered tissues: From advancements in in vitro safety to new horizons in disease modeling. Clin Pharmacol Ther. 2017 04; 101(4):453-457. PMID: 27864923.
    Citations:    Fields:    Translation:HumansAnimals
  4. Chen AE, Borowiak M, Sherwood RI, Kweudjeu A, Melton DA. Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation. Development. 2013 Feb 01; 140(3):675-86. PMID: 23293299.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  5. Egli D, Chen AE, Saphier G, Powers D, Alper M, Katz K, Berger B, Goland R, Leibel RL, Melton DA, Eggan K. Impracticality of egg donor recruitment in the absence of compensation. Cell Stem Cell. 2011 Oct 04; 9(4):293-4. PMID: 21982228.
    Citations: 8     Fields:    Translation:Humans
  6. Egli D, Chen AE, Saphier G, Ichida J, Fitzgerald C, Go KJ, Acevedo N, Patel J, Baetscher M, Kearns WG, Goland R, Leibel RL, Melton DA, Eggan K. Reprogramming within hours following nuclear transfer into mouse but not human zygotes. Nat Commun. 2011 Oct 04; 2:488. PMID: 21971503.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  7. Niakan KK, Ji H, Maehr R, Vokes SA, Rodolfa KT, Sherwood RI, Yamaki M, Dimos JT, Chen AE, Melton DA, McMahon AP, Eggan K. Sox17 promotes differentiation in mouse embryonic stem cells by directly regulating extraembryonic gene expression and indirectly antagonizing self-renewal. Genes Dev. 2010 Feb 01; 24(3):312-26. PMID: 20123909.
    Citations: 96     Fields:    Translation:AnimalsCells
  8. Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell Stem Cell. 2009 Apr 03; 4(4):348-58. PMID: 19341624.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  9. Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 2009 Feb 06; 4(2):103-6. PMID: 19200798.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  10. Huangfu D, Maehr R, Guo W, Eijkelenboom A, Snitow M, Chen AE, Melton DA. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol. 2008 Jul; 26(7):795-7. PMID: 18568017.
    Citations: 528     Fields:    Translation:AnimalsCells
  11. Chen AE, Melton DA. Derivation of human embryonic stem cells by immunosurgery. J Vis Exp. 2007; (10):574. PMID: 18989406.
    Citations: 2     Fields:    Translation:HumansCells
  12. Sherwood RI, Jitianu C, Cleaver O, Shaywitz DA, Lamenzo JO, Chen AE, Golub TR, Melton DA. Prospective isolation and global gene expression analysis of definitive and visceral endoderm. Dev Biol. 2007 Apr 15; 304(2):541-55. PMID: 17328885.
    Citations: 54     Fields:    Translation:AnimalsCells
  13. Chen AE, Fan CM. Targeting gene expression in the mouse somite: adenovirus-mediated gene delivery and whole embryo culture. Genesis. 2005 Jun; 42(2):71-6. PMID: 15880591.
    Citations:    Fields:    Translation:AnimalsCells
  14. Chen AE, Ginty DD, Fan CM. Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature. 2005 Jan 20; 433(7023):317-22. PMID: 15568017.
    Citations: 95     Fields:    Translation:AnimalsCells
  15. Buttitta L, Tanaka TS, Chen AE, Ko MS, Fan CM. Microarray analysis of somitogenesis reveals novel targets of different WNT signaling pathways in the somitic mesoderm. Dev Biol. 2003 Jun 01; 258(1):91-104. PMID: 12781685.
    Citations: 14     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.