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Wagner, Gerhard
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Gerhard Wagner, Ph.D.
Title
Elkan Blout Professor of Biological Chemistry and Molecular Pharmacology
Institution
Harvard Medical School
Department
BCMP
Address
Dept. of Bio Chem & Mol Pharm
Bcmp
240 Longwood Ave
Boston MA 02115
Phone
617/432-3213
Fax
617/432-4383
vCard
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completed student projects
|
research activities and funding
|
selected publications
|
Mentoring
completed student projects
Structural Basis of CD2 Signal Transduction Studied by NMR Spectroscopy
Summer, 06/01/99 - 07/30/99
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
S10OD028526
(WAGNER, GERHARD)
Jul 15, 2020 - Jul 14, 2021
NIH
600 MHz NMR Spectrometer Console
Role: Principal Investigator
R01GM129026
(WAGNER, GERHARD)
Sep 1, 2018 - Jul 31, 2022
NIH
Next Generation Solution NMR Techniques for GPCR Structure, Dynamics and Function
Role: Principal Investigator
R01CA200913
(WAGNER, GERHARD)
Jul 20, 2016 - Jun 30, 2021
NIH
Roles of Eukaryotic Translation Initiation Factors in Gene Expression
Role: Principal Investigator
R01AI108718
(WAGNER, GERHARD)
Aug 6, 2014 - Jul 31, 2019
NIH
The translation apparatus of Leishmania: from basic analysis to pursuit of novel
Role: Principal Investigator
R01HL116391
(WAGNER, GERHARD)
Jun 3, 2013 - May 31, 2018
NIH
Mechanism and inhibition of SREBP-dependent cholesterol/lipid metabolism
Role: Principal Investigator
S10RR026417
(WAGNER, GERHARD)
Nov 20, 2009 - Nov 19, 2011
NIH
800 MHz Triple Resonance Observe (TXO) Detection CryoProbe
Role: Principal Investigator
R21NS067596
(WAGNER, GERHARD)
Sep 25, 2009 - Aug 31, 2011
NIH
Assays for Discovery of Translation Inhibitors
Role: Principal Investigator
R01CA127990
(WAGNER, GERHARD)
Apr 1, 2007 - Jan 31, 2013
NIH
Transcriptional Activator/Coactivator Interactions
Role: Principal Investigator
R01GM075879
(WAGNER, GERHARD)
Sep 23, 2005 - Jul 31, 2015
NIH
Structure and interactions of the Voltage-Dependent Anion Channel(VDAC)
Role: Principal Investigator
R33DK070299
(WAGNER, GERHARD)
Sep 30, 2004 - Jul 31, 2008
NIH
Integrated &Sensitive Metabolomics Platform/Human disease
Role: Principal Investigator
R21DK070299
(WAGNER, GERHARD)
Sep 30, 2004 - Jul 31, 2005
NIH
Integrated, Sensitive Metabolomics Platform (RMI)
Role: Principal Investigator
P41RR015301
(EALICK, STEVEN E)
Jun 15, 2001 - Mar 31, 2013
NIH/NCRR
An Undulator Resource for Structural Biology
Role: Co-Principal Investigator
S10RR015742
(WAGNER, GERHARD)
Mar 1, 2001 - Feb 28, 2002
NIH
CRYOPROBE FOR A 600 MHZ NMR SPECTROMETER
Role: Principal Investigator
P01AI043649
(REINHERZ, ELLIS L)
Aug 1, 1998 - Jul 31, 2007
NIH
HIVRAD: Structural approaches to vaccine development
Role: Co-Principal Investigator
R13GM055537
(WAGNER, GERHARD)
Feb 5, 1997 - Feb 4, 1998
NIH
CONFERENCE ON FRONTIERS OF NMR IN MOLECULAR BIOLOGY
Role: Principal Investigator
R01AI037581
(WAGNER, GERHARD)
Jul 15, 1996 - Oct 31, 2021
NIH
Structural Basis of Immune Cell Receptor Function
Role: Principal Investigator
R01CA068262
(WAGNER, GERHARD)
May 8, 1996 - Feb 28, 2011
NIH
Mechanisms of Eukaryotic Translation Initiation
Role: Principal Investigator
P01GM047467
(WAGNER, GERHARD)
May 1, 1992 - Jun 30, 2010
NIH
NMR and Computational Studies of Biomolecules
Role: Principal Investigator
R01CA054513
(WAGNER, GERHARD)
Aug 1, 1991 - Jul 31, 1994
NIH
ANTI-FOLATE INDUCED CONFORMATIONAL CHANGES IN HUMAN DHFR
Role: Principal Investigator
P41RR006009
(LEVINE, MICHAEL J)
Sep 1, 1990 - Jul 31, 2013
NIH/NCRR
High Performance Computing for Biomedical Research
Role: Co-Principal Investigator
R01GM038608
(WAGNER, GERHARD)
Apr 1, 1988 - Nov 30, 1998
NIH
NMR STUDIES OF PROTEIN TARGET INTERACTIONS
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Jayaraj A, Schwanz HA, Spencer DJ, Bhasin S, Hamilton JA, Jayaram B, Goldman AL, Krishna M, Krishnan M, Shah A, Jin Z, Krenzel E, Nair SN, Ramesh S, Guo W, Wagner G, Arthanari H, Peng L, Lawney B, Jasuja R. Allosterically Coupled Multisite Binding of Testosterone to Human Serum Albumin. Endocrinology. 2021 Feb 01; 162(2).
PMID:
33125473
.
Citations:
Fields:
End
Endocrinology
Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening. iScience. 2021 Feb 19; 24(2):102021.
PMID:
33426509
.
Citations:
1
Mizsei R, Li X, Chen WN, Szabo M, Wang JH, Wagner G, Reinherz EL, Mallis RJ. A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes. J Biol Chem. 2021 Jan 04.
PMID:
33397788
.
Citations:
Fields:
Bio
Biochemistry
Li X, Mizsei R, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL. Pre-T cell receptors topologically sample self-ligands during thymocyte ß-selection. Science. 2021 01 08; 371(6525):181-185.
PMID:
33335016
.
Citations:
Fields:
Sci
Science
Behera SP, Dubey A, Chen WN, De Paula VS, Zhang M, Sgourakis NG, Bermel W, Wagner G, Coote PW, Arthanari H. Nearest-neighbor NMR spectroscopy: categorizing spectral peaks by their adjacent nuclei. Nat Commun. 2020 11 03; 11(1):5547.
PMID:
33144564
.
Citations:
1
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Tyukhtenko S, Ma X, Rajarshi G, Karageorgos I, Anderson KW, Hudgens JW, Guo JJ, Nasr ML, Zvonok N, Vemuri K, Wagner G, Makriyannis A. Conformational gating, dynamics and allostery in human monoacylglycerol lipase. Sci Rep. 2020 10 28; 10(1):18531.
PMID:
33116203
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Cells
Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, Hu X, Wang H, Zhang M, Manuel VJ, Tan L, He Z, Sun ZJ, Lee VMY, Wagner G, Yuan J. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 11; 587(7832):133-138.
PMID:
32968279
.
Citations:
1
Fields:
Sci
Science
Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A Multi-Pronged Approach Targeting SARS-CoV-2 Proteins Using Ultra-Large Virtual Screening. ChemRxiv. 2020 Jul 24.
PMID:
33200116
.
Citations:
Boeszoermenyi A, Ogórek B, Jain A, Arthanari H, Wagner G. The precious fluorine on the ring: fluorine NMR for biological systems. J Biomol NMR. 2020 Sep; 74(8-9):365-379.
PMID:
32651751
.
Citations:
1
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Padmanabha Das KM, Shih WM, Wagner G, Nasr ML. Large Nanodiscs: A Potential Game Changer in Structural Biology of Membrane Protein Complexes and Virus Entry. Front Bioeng Biotechnol. 2020; 8:539.
PMID:
32596222
.
Citations:
3
Tupperwar N, Meleppattu S, Shrivastava R, Baron N, Gilad A, Wagner G, Léger-Abraham M, Shapira M. A newly identified Leishmania IF4E-interacting protein, Leish4E-IP2, modulates the activity of cap-binding protein paralogs. Nucleic Acids Res. 2020 05 07; 48(8):4405-4417.
PMID:
32232353
.
Citations:
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Gorgulla C, Boeszoermenyi A, Wang ZF, Fischer PD, Coote PW, Padmanabha Das KM, Malets YS, Radchenko DS, Moroz YS, Scott DA, Fackeldey K, Hoffmann M, Iavniuk I, Wagner G, Arthanari H. An open-source drug discovery platform enables ultra-large virtual screens. Nature. 2020 04; 580(7805):663-668.
PMID:
32152607
.
Citations:
16
Fields:
Sci
Science
Böhm R, Amodeo GF, Murlidaran S, Chavali S, Wagner G, Winterhalter M, Brannigan G, Hiller S. The Structural Basis for Low Conductance in the Membrane Protein VDAC upon ß-NADH Binding and Voltage Gating. Structure. 2020 02 04; 28(2):206-214.e4.
PMID:
31862297
.
Citations:
4
Fields:
Bio
Biochemistry
Bio
Biotechnology
Mol
Molecular Biology
Wang Y, Kaur P, Sun ZJ, Elbahnasawy MA, Hayati Z, Qiao ZS, Bui NN, Chile C, Nasr ML, Wagner G, Wang JH, Song L, Reinherz EL, Kim M. Topological analysis of the gp41 MPER on lipid bilayers relevant to the metastable HIV-1 envelope prefusion state. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22556-22566.
PMID:
31624123
.
Citations:
3
Fields:
Sci
Science
Translation:
Humans
Cells
Ling J, Cheloha RW, McCaul N, Sun ZJ, Wagner G, Ploegh HL. A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity. Mol Immunol. 2019 10; 114:513-523.
PMID:
31518855
.
Citations:
6
Fields:
All
Allergy and Immunology
Mol
Molecular Biology
Translation:
Humans
Cells
Eddy MT, Yu TY, Wagner G, Griffin RG. Structural characterization of the human membrane protein VDAC2 in lipid bilayers by MAS NMR. J Biomol NMR. 2019 Sep; 73(8-9):451-460.
PMID:
31407201
.
Citations:
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Humans
Cells
Tam B, Sherf D, Cohen S, Eisdorfer SA, Perez M, Soffer A, Vilenchik D, Akabayov SR, Wagner G, Akabayov B. Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis. Chem Sci. 2019 Oct 14; 10(38):8764-8767.
PMID:
31803448
.
Citations:
Arthanari H, Takeuchi K, Dubey A, Wagner G. Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins. Curr Opin Struct Biol. 2019 10; 58:294-304.
PMID:
31327528
.
Citations:
3
Fields:
Bio
Biochemistry
Mol
Molecular Biology
Kaptein R, Wagner G. Integrative methods in structural biology. J Biomol NMR. 2019 Jul; 73(6-7):261-263.
PMID:
31313058
.
Citations:
2
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Humans
Boeszoermenyi A, Chhabra S, Dubey A, Radeva DL, Burdzhiev NT, Chanev CD, Petrov OI, Gelev VM, Zhang M, Anklin C, Kovacs H, Wagner G, Kuprov I, Takeuchi K, Arthanari H. Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics. Nat Methods. 2019 04; 16(4):333-340.
PMID:
30858598
.
Citations:
15
Fields:
Cli
Clinical Laboratory Techniques
Translation:
Cells
Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL. NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology. J Biomol NMR. 2019 Jul; 73(6-7):319-332.
PMID:
30815789
.
Citations:
5
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Humans
Cells
Wagner G. Editorial. J Biomol NMR. 2019 Feb; 73(1-2):1.
PMID:
30825034
.
Citations:
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS. High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3. Sci Rep. 2018 11 30; 8(1):17512.
PMID:
30504845
.
Citations:
4
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL. The T Cell Antigen Receptor a Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Immunity. 2018 11 20; 49(5):829-841.e6.
PMID:
30389415
.
Citations:
11
Fields:
All
Allergy and Immunology
Translation:
Cells
Robson S, Arthanari H, Hyberts SG, Wagner G. Nonuniform Sampling for NMR Spectroscopy. Methods Enzymol. 2019; 614:263-291.
PMID:
30611427
.
Citations:
4
Fields:
Bio
Biochemistry
Translation:
Humans
O'Day EM, Idos GE, Hill C, Chen JW, Wagner G. Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells. Onco Targets Ther. 2018; 11:6827-6838.
PMID:
30349315
.
Citations:
2
Zhao Z, Zhang M, Hogle JM, Shih WM, Wagner G, Nasr ML. DNA-Corralled Nanodiscs for the Structural and Functional Characterization of Membrane Proteins and Viral Entry. J Am Chem Soc. 2018 08 29; 140(34):10639-10643.
PMID:
30094995
.
Citations:
7
Fields:
Che
Chemistry
Translation:
Humans
Cells
Coote PW, Robson SA, Dubey A, Boeszoermenyi A, Zhao M, Wagner G, Arthanari H. Optimal control theory enables homonuclear decoupling without Bloch-Siegert shifts in NMR spectroscopy. Nat Commun. 2018 08 01; 9(1):3014.
PMID:
30069002
.
Citations:
4
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Meleppattu S, Arthanari H, Zinoviev A, Boeszoermenyi A, Wagner G, Shapira M, Léger-Abraham M. Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major. Nucleic Acids Res. 2018 04 20; 46(7):3791-3801.
PMID:
29562352
.
Citations:
6
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Nasr ML, Wagner G. Covalently circularized nanodiscs; challenges and applications. Curr Opin Struct Biol. 2018 08; 51:129-134.
PMID:
29677570
.
Citations:
7
Fields:
Bio
Biochemistry
Mol
Molecular Biology
Translation:
Cells
Chhabra S, Fischer P, Takeuchi K, Dubey A, Ziarek JJ, Boeszoermenyi A, Mathieu D, Bermel W, Davey NE, Wagner G, Arthanari H. 15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):E1710-E1719.
PMID:
29432148
.
Citations:
4
Fields:
Sci
Science
Translation:
Cells
Robson SA, Takeuchi K, Boeszoermenyi A, Coote PW, Dubey A, Hyberts S, Wagner G, Arthanari H. Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment. Nat Commun. 2018 01 24; 9(1):356.
PMID:
29367739
.
Citations:
5
Fields:
Bio
Biology
Sci
Science
Translation:
Cells
Yi T, Wagner G. Cytocapsular tubes conduct cell translocation. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):E1137-E1146.
PMID:
29339492
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Hagn F, Nasr ML, Wagner G. Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Nat Protoc. 2018 Jan; 13(1):79-98.
PMID:
29215632
.
Citations:
26
Fields:
Cli
Clinical Laboratory Techniques
Sci
Science
Takeuchi K, Arthanari H, Shimada I, Wagner G. Erratum to: Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR. J Biomol NMR. 2017 12; 69(4):245.
PMID:
29230599
.
Citations:
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Mallis RJ, Arthanari H, Lang MJ, Reinherz EL, Wagner G. NMR-directed design of pre-TCRß and pMHC molecules implies a distinct geometry for pre-TCR relative to aßTCR recognition of pMHC. J Biol Chem. 2018 01 19; 293(3):754-766.
PMID:
29101227
.
Citations:
1
Fields:
Bio
Biochemistry
Translation:
Cells
Ziarek JJ, Baptista D, Wagner G. Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology. J Mol Med (Berl). 2018 01; 96(1):1-8.
PMID:
28643003
.
Citations:
3
Fields:
Gen
Genetics
Mol
Molecular Biology
Sekiyama N, Boeszoermenyi A, Arthanari H, Wagner G, Léger-Abraham M. 1H, 13C, and 15N backbone chemical shift assignments of 4E-BP144-87 and 4E-BP144-87 bound to eIF4E. Biomol NMR Assign. 2017 Oct; 11(2):187-191.
PMID:
28589219
.
Citations:
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Humans
Cells
Coote P, Anklin C, Massefski W, Wagner G, Arthanari H. Rapid convergence of optimal control in NMR using numerically-constructed toggling frames. J Magn Reson. 2017 08; 281:94-103.
PMID:
28578162
.
Citations:
3
Fields:
Dia
Diagnostic Imaging
Hyberts SG, Robson SA, Wagner G. Interpolating and extrapolating with hmsIST: seeking a tmax for optimal sensitivity, resolution and frequency accuracy. J Biomol NMR. 2017 Jun; 68(2):139-154.
PMID:
28332026
.
Citations:
9
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K. Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017 03 14; 18(11):2651-2663.
PMID:
28297669
.
Citations:
17
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G. Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nat Methods. 2017 01; 14(1):49-52.
PMID:
27869813
.
Citations:
47
Fields:
Cli
Clinical Laboratory Techniques
Translation:
Humans
Cells
Takeuchi K, Arthanari H, Wagner G. Perspective: revisiting the field dependence of TROSY sensitivity. J Biomol NMR. 2016 12; 66(4):221-225.
PMID:
27866370
.
Citations:
7
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Ilic S, Akabayov SR, Arthanari H, Wagner G, Richardson CC, Akabayov B. Identification of DNA primase inhibitors via a combined fragment-based and virtual screening. Sci Rep. 2016 11 02; 6:36322.
PMID:
27805033
.
Citations:
4
Fields:
Sci
Science
Translation:
Humans
Cells
Das DK, Mallis RJ, Duke-Cohan JS, Hussey RE, Tetteh PW, Hilton M, Wagner G, Lang MJ, Reinherz EL. Pre-T Cell Receptors (Pre-TCRs) Leverage Vß Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands. J Biol Chem. 2016 Dec 02; 291(49):25292-25305.
PMID:
27707880
.
Citations:
15
Fields:
Bio
Biochemistry
Translation:
Animals
Cells
Sun ZJ, Bhanu MK, Allan MG, Arthanari H, Wagner G, Hanna J. Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins. PLoS One. 2016; 11(9):e0163660.
PMID:
27662200
.
Citations:
1
Fields:
Med
Medicine (General)
Sci
Science
Imai S, Kumar P, Hellen CU, D'Souza VM, Wagner G. An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation. Nat Struct Mol Biol. 2016 09; 23(9):859-64.
PMID:
27525590
.
Citations:
14
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Coote P, Bermel W, Wagner G, Arthanari H. Analytical optimization of active bandwidth and quality factor for TOCSY experiments in NMR spectroscopy. J Biomol NMR. 2016 09; 66(1):9-20.
PMID:
27515670
.
Citations:
1
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K. Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation. Nucleic Acids Res. 2016 Oct 14; 44(18):8704-8713.
PMID:
27325740
.
Citations:
9
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G, Hagn F. Conformational dynamics of a G-protein a subunit is tightly regulated by nucleotide binding. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3629-38.
PMID:
27298341
.
Citations:
24
Fields:
Sci
Science
Translation:
Humans
Cells
Salvi N, Papadopoulos E, Blackledge M, Wagner G. The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex. Angew Chem Int Ed Engl. 2016 06 13; 55(25):7176-9.
PMID:
27162083
.
Citations:
3
Fields:
Che
Chemistry
Translation:
Humans
Cells
Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M, Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Näär AM, Arthanari H. Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature. 2016 Feb 25; 530(7591):485-9.
PMID:
26886795
.
Citations:
38
Fields:
Sci
Science
Translation:
Animals
Cells
Takeuchi K, Arthanari H, Imai M, Wagner G, Shimada I. Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions. J Biomol NMR. 2016 Feb; 64(2):143-51.
PMID:
26800993
.
Citations:
12
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Cells
Viegas A, Viennet T, Yu TY, Schumann F, Bermel W, Wagner G, Etzkorn M. UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection. J Biomol NMR. 2016 Jan; 64(1):9-15.
PMID:
26728075
.
Citations:
6
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Takeuchi K, Arthanari H, Shimada I, Wagner G. Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR. J Biomol NMR. 2015 Dec; 63(4):323-331.
PMID:
26497830
.
Citations:
17
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Cells
Nartey W, Basak S, Kamariah N, Manimekalai MS, Robson S, Wagner G, Eisenhaber B, Eisenhaber F, Grüber G. NMR studies reveal a novel grab and release mechanism for efficient catalysis of the bacterial 2-Cys peroxiredoxin machinery. FEBS J. 2015 Dec; 282(23):4620-38.
PMID:
26402142
.
Citations:
4
Fields:
Bio
Biochemistry
Translation:
Cells
Linser R, Salvi N, Briones R, Rovó P, de Groot BL, Wagner G. The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):12390-5.
PMID:
26392539
.
Citations:
4
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Raschle T, Lin C, Jungmann R, Shih WM, Wagner G. Controlled Co-reconstitution of Multiple Membrane Proteins in Lipid Bilayer Nanodiscs Using DNA as a Scaffold. ACS Chem Biol. 2015 Nov 20; 10(11):2448-54.
PMID:
26356202
.
Citations:
7
Fields:
Bio
Biochemistry
Bio
Biology
Translation:
Cells
Boeszoermenyi A, Nagy HM, Arthanari H, Pillip CJ, Lindermuth H, Luna RE, Wagner G, Zechner R, Zangger K, Oberer M. Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring. J Biol Chem. 2015 Oct 30; 290(44):26361-72.
PMID:
26350461
.
Citations:
15
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Brazin KN, Mallis RJ, Das DK, Feng Y, Hwang W, Wang JH, Wagner G, Lang MJ, Reinherz EL. Structural Features of the aßTCR Mechanotransduction Apparatus That Promote pMHC Discrimination. Front Immunol. 2015; 6:441.
PMID:
26388869
.
Citations:
25
Fields:
All
Allergy and Immunology
Mallis RJ, Reinherz EL, Wagner G, Arthanari H. Backbone resonance assignment of N15, N30 and D10 T cell receptor ß subunits. Biomol NMR Assign. 2016 Apr; 10(1):35-9.
PMID:
26275917
.
Citations:
2
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Cells
Sekiyama N, Arthanari H, Papadopoulos E, Rodriguez-Mias RA, Wagner G, Léger-Abraham M. Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4036-45.
PMID:
26170285
.
Citations:
32
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H. Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9010-5.
PMID:
26150520
.
Citations:
25
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL. Pre-TCR ligand binding impacts thymocyte development before aßTCR expression. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8373-8.
PMID:
26056289
.
Citations:
25
Fields:
Sci
Science
Translation:
Animals
Cells
O'Day E, Le MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-22.
PMID:
26045559
.
Citations:
6
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Güttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Commun. 2015 May 28; 6:7194.
PMID:
26018492
.
Citations:
6
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Milbradt AG, Arthanari H, Takeuchi K, Boeszoermenyi A, Hagn F, Wagner G. Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY. J Biomol NMR. 2015 Jul; 62(3):291-301.
PMID:
25957757
.
Citations:
9
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Kaptein R, Wagner G. NMR studies of membrane proteins. J Biomol NMR. 2015 Apr; 61(3-4):181-4.
PMID:
25840906
.
Citations:
2
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Cells
Eddy MT, Su Y, Silvers R, Andreas L, Clark L, Wagner G, Pintacuda G, Emsley L, Griffin RG. Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR. J Biomol NMR. 2015 Apr; 61(3-4):299-310.
PMID:
25634301
.
Citations:
12
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Humans
Cells
Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ. Force-dependent transition in the T-cell receptor ß-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1517-22.
PMID:
25605925
.
Citations:
75
Fields:
Sci
Science
Translation:
Cells
Eddy MT, Andreas L, Teijido O, Su Y, Clark L, Noskov SY, Wagner G, Rostovtseva TK, Griffin RG. Magic angle spinning nuclear magnetic resonance characterization of voltage-dependent anion channel gating in two-dimensional lipid crystalline bilayers. Biochemistry. 2015 Feb 03; 54(4):994-1005.
PMID:
25545271
.
Citations:
10
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Hagn F, Wagner G. Structure refinement and membrane positioning of selectively labeled OmpX in phospholipid nanodiscs. J Biomol NMR. 2015 Apr; 61(3-4):249-60.
PMID:
25430058
.
Citations:
14
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Cells
Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P. G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18201-6.
PMID:
25404306
.
Citations:
96
Fields:
Sci
Science
Translation:
Humans
Cells
Akabayov SR, Akabayov B, Wagner G. Human translation initiation factor eIF4G1 possesses a low-affinity ATP binding site facing the ATP-binding cleft of eIF4A in the eIF4G/eIF4A complex. Biochemistry. 2014 Oct 21; 53(41):6422-5.
PMID:
25255371
.
Citations:
1
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Wommack AJ, Ziarek JJ, Tomaras J, Chileveru HR, Zhang Y, Wagner G, Nolan EM. Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. J Am Chem Soc. 2014 Oct 01; 136(39):13494-7.
PMID:
25181039
.
Citations:
9
Fields:
Che
Chemistry
Translation:
Humans
Cells
Takeuchi K, Sun ZY, Li S, Gal M, Wagner G. NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states. Biomol NMR Assign. 2015 Apr; 9(1):201-5.
PMID:
25209144
.
Citations:
2
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Humans
Cells
Hiraishi H, Oatman J, Haller SL, Blunk L, McGivern B, Morris J, Papadopoulos E, Gutierrez W, Gordon M, Bokhari W, Ikeda Y, Miles D, Fellers J, Asano M, Wagner G, Tazi L, Rothenburg S, Brown SJ, Asano K. Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression. Nucleic Acids Res. 2014; 42(16):10321-30.
PMID:
25147208
.
Citations:
8
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Yi T, Kabha E, Papadopoulos E, Wagner G. 4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis. Oncotarget. 2014 Aug 15; 5(15):6028-37.
PMID:
25115391
.
Citations:
13
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Linser R, Bardiaux B, Andreas LB, Hyberts SG, Morris VK, Pintacuda G, Sunde M, Kwan AH, Wagner G. Solid-state NMR structure determination from diagonal-compensated, sparsely nonuniform-sampled 4D proton-proton restraints. J Am Chem Soc. 2014 Aug 06; 136(31):11002-10.
PMID:
24988008
.
Citations:
15
Fields:
Che
Chemistry
Translation:
Cells
Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G. Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3187-95.
PMID:
25049413
.
Citations:
26
Fields:
Sci
Science
Translation:
Humans
Cells
Coote P, Leigh KE, Yu TY, Khaneja N, Wagner G, Arthanari H. A new broadband homonuclear mixing pulse for NMR with low applied power. J Chem Phys. 2014 Jul 14; 141(2):024201.
PMID:
25028012
.
Citations:
1
Fields:
Bio
Biophysics
Che
Chemistry
Phy
Physics
Linser R, Gelev V, Hagn F, Arthanari H, Hyberts SG, Wagner G. Selective methyl labeling of eukaryotic membrane proteins using cell-free expression. J Am Chem Soc. 2014 Aug 13; 136(32):11308-10.
PMID:
24937763
.
Citations:
8
Fields:
Che
Chemistry
Translation:
Humans
Cells
Gal M, Li S, Luna RE, Takeuchi K, Wagner G. The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain. Structure. 2014 Jul 08; 22(7):1016-27.
PMID:
24954618
.
Citations:
5
Fields:
Bio
Biochemistry
Bio
Biotechnology
Mol
Molecular Biology
Translation:
Humans
Cells
Edmonds KA, Wagner G. (1)H, (13)C, and (15)N backbone and sidechain chemical shift assignments for the HEAT2 domain of human eIF4GI. Biomol NMR Assign. 2015 Apr; 9(1):157-60.
PMID:
24929364
.
Citations:
Fields:
Mol
Molecular Biology
Nuc
Nuclear Medicine
Translation:
Humans
Cells
Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M. Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction. J Med Chem. 2014 Jun 26; 57(12):5094-111.
PMID:
24827861
.
Citations:
8
Fields:
Che
Chemistry
Translation:
Humans
Cells
Elter S, Raschle T, Arens S, Viegas A, Gelev V, Etzkorn M, Wagner G. The use of amphipols for NMR structural characterization of 7-TM proteins. J Membr Biol. 2014 Oct; 247(9-10):957-64.
PMID:
24858950
.
Citations:
8
Fields:
Mol
Molecular Biology
Translation:
Cells
Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL. Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2014 Jul 04; 289(27):18880-92.
PMID:
24849600
.
Citations:
11
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Avnir Y, Tallarico AS, Zhu Q, Bennett AS, Connelly G, Sheehan J, Sui J, Fahmy A, Huang CY, Cadwell G, Bankston LA, McGuire AT, Stamatatos L, Wagner G, Liddington RC, Marasco WA. Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses. PLoS Pathog. 2014 May; 10(5):e1004103.
PMID:
24788925
.
Citations:
43
Fields:
Mic
Microbiology
Translation:
Humans
Cells
Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G. Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2182-90.
PMID:
24782546
.
Citations: