Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Gerhard Wagner, Ph.D.

Title
Institution
Department
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Mentoring
completed student projects
Structural Basis of CD2 Signal Transduction Studied by NMR Spectroscopy
Summer, 06/01/99 - 07/30/99

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. S10OD028526 (WAGNER, GERHARD) Jul 15, 2020 - Jul 14, 2021
    NIH
    600 MHz NMR Spectrometer Console
    Role: Principal Investigator
  2. R01GM129026 (WAGNER, GERHARD) Sep 1, 2018 - Jul 31, 2022
    NIH
    Next Generation Solution NMR Techniques for GPCR Structure, Dynamics and Function
    Role: Principal Investigator
  3. R01CA200913 (WAGNER, GERHARD) Jul 20, 2016 - Jun 30, 2021
    NIH
    Roles of Eukaryotic Translation Initiation Factors in Gene Expression
    Role: Principal Investigator
  4. R01AI108718 (WAGNER, GERHARD) Aug 6, 2014 - Jul 31, 2019
    NIH
    The translation apparatus of Leishmania: from basic analysis to pursuit of novel
    Role: Principal Investigator
  5. R01HL116391 (WAGNER, GERHARD) Jun 3, 2013 - May 31, 2018
    NIH
    Mechanism and inhibition of SREBP-dependent cholesterol/lipid metabolism
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wu S, Wagner G. Deep computational analysis details dysregulation of eukaryotic translation initiation complex eIF4F in human cancers. Cell Syst. 2021 Jul 27. PMID: 34358439.
    Citations:    Fields:    
  2. Gorgulla C, Çinaroglu SS, Fischer PD, Fackeldey K, Wagner G, Arthanari H. VirtualFlow Ants-Ultra-Large Virtual Screenings with Artificial Intelligence Driven Docking Algorithm Based on Ant Colony Optimization. Int J Mol Sci. 2021 May 28; 22(11). PMID: 34071676.
    Citations:    Fields:    Translation:Cells
  3. Fischer PD, Papadopoulos E, Dempersmier JM, Wang ZF, Nowak RP, Donovan KA, Kalabathula J, Gorgulla C, Junghanns PPM, Kabha E, Dimitrakakis N, Petrov OI, Mitsiades C, Ducho C, Gelev V, Fischer ES, Wagner G, Arthanari H. A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders. Eur J Med Chem. 2021 Jul 05; 219:113435. PMID: 33892272.
    Citations:    Fields:    Translation:HumansCells
  4. Gandhi AK, Sun ZJ, Kim WM, Huang YH, Kondo Y, Bonsor DA, Sundberg EJ, Wagner G, Kuchroo VK, Petsko GA, Blumberg RS. Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium. Commun Biol. 2021 03 19; 4(1):360. PMID: 33742094.
    Citations:    Translation:HumansCells
  5. Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Plückthun A, Brown A, Nasr ML, Wagner G. Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs. Nat Struct Mol Biol. 2021 03; 28(3):258-267. PMID: 33633398.
    Citations: 5     Fields:    Translation:HumansCells
  6. Jayaraj A, Schwanz HA, Spencer DJ, Bhasin S, Hamilton JA, Jayaram B, Goldman AL, Krishna M, Krishnan M, Shah A, Jin Z, Krenzel E, Nair SN, Ramesh S, Guo W, Wagner G, Arthanari H, Peng L, Lawney B, Jasuja R. Allosterically Coupled Multisite Binding of Testosterone to Human Serum Albumin. Endocrinology. 2021 02 01; 162(2). PMID: 33125473.
    Citations: 2     Fields:    Translation:Cells
  7. Mizsei R, Li X, Chen WN, Szabo M, Wang JH, Wagner G, Reinherz EL, Mallis RJ. A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes. J Biol Chem. 2021 Jan-Jun; 296:100255. PMID: 33837736.
    Citations:    Fields:    Translation:HumansCells
  8. Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening. iScience. 2021 Feb 19; 24(2):102021. PMID: 33426509.
    Citations: 5     
  9. Mizsei R, Li X, Chen WN, Szabo M, Wang JH, Wagner G, Reinherz EL, Mallis RJ. A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes. J Biol Chem. 2021 Jan 04. PMID: 33397788.
    Citations:    Fields:    
  10. Li X, Mizsei R, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL. Pre-T cell receptors topologically sample self-ligands during thymocyte ß-selection. Science. 2021 01 08; 371(6525):181-185. PMID: 33335016.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Behera SP, Dubey A, Chen WN, De Paula VS, Zhang M, Sgourakis NG, Bermel W, Wagner G, Coote PW, Arthanari H. Nearest-neighbor NMR spectroscopy: categorizing spectral peaks by their adjacent nuclei. Nat Commun. 2020 11 03; 11(1):5547. PMID: 33144564.
    Citations: 1     Fields:    Translation:HumansCells
  12. Tyukhtenko S, Ma X, Rajarshi G, Karageorgos I, Anderson KW, Hudgens JW, Guo JJ, Nasr ML, Zvonok N, Vemuri K, Wagner G, Makriyannis A. Conformational gating, dynamics and allostery in human monoacylglycerol lipase. Sci Rep. 2020 10 28; 10(1):18531. PMID: 33116203.
    Citations:    Fields:    Translation:HumansCells
  13. Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, Hu X, Wang H, Zhang M, Manuel VJ, Tan L, He Z, Sun ZJ, Lee VMY, Wagner G, Yuan J. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 11; 587(7832):133-138. PMID: 32968279.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  14. Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A Multi-Pronged Approach Targeting SARS-CoV-2 Proteins Using Ultra-Large Virtual Screening. ChemRxiv. 2020 Jul 24. PMID: 33200116.
    Citations: 1     
  15. Boeszoermenyi A, Ogórek B, Jain A, Arthanari H, Wagner G. The precious fluorine on the ring: fluorine NMR for biological systems. J Biomol NMR. 2020 Sep; 74(8-9):365-379. PMID: 32651751.
    Citations: 1     Fields:    Translation:Cells
  16. Padmanabha Das KM, Shih WM, Wagner G, Nasr ML. Large Nanodiscs: A Potential Game Changer in Structural Biology of Membrane Protein Complexes and Virus Entry. Front Bioeng Biotechnol. 2020; 8:539. PMID: 32596222.
    Citations: 4     
  17. Tupperwar N, Meleppattu S, Shrivastava R, Baron N, Gilad A, Wagner G, Léger-Abraham M, Shapira M. A newly identified Leishmania IF4E-interacting protein, Leish4E-IP2, modulates the activity of cap-binding protein paralogs. Nucleic Acids Res. 2020 05 07; 48(8):4405-4417. PMID: 32232353.
    Citations: 3     Fields:    Translation:AnimalsCells
  18. Gorgulla C, Boeszoermenyi A, Wang ZF, Fischer PD, Coote PW, Padmanabha Das KM, Malets YS, Radchenko DS, Moroz YS, Scott DA, Fackeldey K, Hoffmann M, Iavniuk I, Wagner G, Arthanari H. An open-source drug discovery platform enables ultra-large virtual screens. Nature. 2020 04; 580(7805):663-668. PMID: 32152607.
    Citations: 32     Fields:    
  19. Böhm R, Amodeo GF, Murlidaran S, Chavali S, Wagner G, Winterhalter M, Brannigan G, Hiller S. The Structural Basis for Low Conductance in the Membrane Protein VDAC upon ß-NADH Binding and Voltage Gating. Structure. 2020 02 04; 28(2):206-214.e4. PMID: 31862297.
    Citations: 8     Fields:    Translation:HumansCells
  20. Wang Y, Kaur P, Sun ZJ, Elbahnasawy MA, Hayati Z, Qiao ZS, Bui NN, Chile C, Nasr ML, Wagner G, Wang JH, Song L, Reinherz EL, Kim M. Topological analysis of the gp41 MPER on lipid bilayers relevant to the metastable HIV-1 envelope prefusion state. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22556-22566. PMID: 31624123.
    Citations: 5     Fields:    Translation:HumansCells
  21. Ling J, Cheloha RW, McCaul N, Sun ZJ, Wagner G, Ploegh HL. A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity. Mol Immunol. 2019 10; 114:513-523. PMID: 31518855.
    Citations: 8     Fields:    Translation:HumansCells
  22. Eddy MT, Yu TY, Wagner G, Griffin RG. Structural characterization of the human membrane protein VDAC2 in lipid bilayers by MAS NMR. J Biomol NMR. 2019 Sep; 73(8-9):451-460. PMID: 31407201.
    Citations: 3     Fields:    Translation:HumansCells
  23. Tam B, Sherf D, Cohen S, Eisdorfer SA, Perez M, Soffer A, Vilenchik D, Akabayov SR, Wagner G, Akabayov B. Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis. Chem Sci. 2019 Oct 14; 10(38):8764-8767. PMID: 31803448.
    Citations: 1     
  24. Arthanari H, Takeuchi K, Dubey A, Wagner G. Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins. Curr Opin Struct Biol. 2019 10; 58:294-304. PMID: 31327528.
    Citations: 7     Fields:    
  25. Kaptein R, Wagner G. Integrative methods in structural biology. J Biomol NMR. 2019 Jul; 73(6-7):261-263. PMID: 31313058.
    Citations: 3     Fields:    Translation:Humans
  26. Boeszoermenyi A, Chhabra S, Dubey A, Radeva DL, Burdzhiev NT, Chanev CD, Petrov OI, Gelev VM, Zhang M, Anklin C, Kovacs H, Wagner G, Kuprov I, Takeuchi K, Arthanari H. Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics. Nat Methods. 2019 04; 16(4):333-340. PMID: 30858598.
    Citations: 17     Fields:    Translation:Cells
  27. Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL. NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology. J Biomol NMR. 2019 Jul; 73(6-7):319-332. PMID: 30815789.
    Citations: 7     Fields:    Translation:HumansCells
  28. Wagner G. Editorial. J Biomol NMR. 2019 Feb; 73(1-2):1. PMID: 30825034.
    Citations:    Fields:    
  29. Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS. High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3. Sci Rep. 2018 11 30; 8(1):17512. PMID: 30504845.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  30. Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL. The T Cell Antigen Receptor a Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Immunity. 2018 11 20; 49(5):829-841.e6. PMID: 30389415.
    Citations: 15     Fields:    Translation:Cells
  31. Robson S, Arthanari H, Hyberts SG, Wagner G. Nonuniform Sampling for NMR Spectroscopy. Methods Enzymol. 2019; 614:263-291. PMID: 30611427.
    Citations: 6     Fields:    Translation:Humans
  32. O'Day EM, Idos GE, Hill C, Chen JW, Wagner G. Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells. Onco Targets Ther. 2018; 11:6827-6838. PMID: 30349315.
    Citations: 2     
  33. Zhao Z, Zhang M, Hogle JM, Shih WM, Wagner G, Nasr ML. DNA-Corralled Nanodiscs for the Structural and Functional Characterization of Membrane Proteins and Viral Entry. J Am Chem Soc. 2018 08 29; 140(34):10639-10643. PMID: 30094995.
    Citations: 9     Fields:    Translation:HumansCells
  34. Coote PW, Robson SA, Dubey A, Boeszoermenyi A, Zhao M, Wagner G, Arthanari H. Optimal control theory enables homonuclear decoupling without Bloch-Siegert shifts in NMR spectroscopy. Nat Commun. 2018 08 01; 9(1):3014. PMID: 30069002.
    Citations: 5     Fields:    Translation:Humans
  35. Meleppattu S, Arthanari H, Zinoviev A, Boeszoermenyi A, Wagner G, Shapira M, Léger-Abraham M. Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major. Nucleic Acids Res. 2018 04 20; 46(7):3791-3801. PMID: 29562352.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  36. Nasr ML, Wagner G. Covalently circularized nanodiscs; challenges and applications. Curr Opin Struct Biol. 2018 08; 51:129-134. PMID: 29677570.
    Citations: 8     Fields:    Translation:Cells
  37. Chhabra S, Fischer P, Takeuchi K, Dubey A, Ziarek JJ, Boeszoermenyi A, Mathieu D, Bermel W, Davey NE, Wagner G, Arthanari H. 15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):E1710-E1719. PMID: 29432148.
    Citations: 4     Fields:    Translation:Cells
  38. Robson SA, Takeuchi K, Boeszoermenyi A, Coote PW, Dubey A, Hyberts S, Wagner G, Arthanari H. Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment. Nat Commun. 2018 01 24; 9(1):356. PMID: 29367739.
    Citations: 5     Fields:    Translation:Cells
  39. Yi T, Wagner G. Cytocapsular tubes conduct cell translocation. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):E1137-E1146. PMID: 29339492.
    Citations:    Fields:    Translation:HumansAnimalsCells
  40. Hagn F, Nasr ML, Wagner G. Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Nat Protoc. 2018 Jan; 13(1):79-98. PMID: 29215632.
    Citations: 31     Fields:    
  41. Takeuchi K, Arthanari H, Shimada I, Wagner G. Erratum to: Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR. J Biomol NMR. 2017 12; 69(4):245. PMID: 29230599.
    Citations:    Fields:    
  42. Mallis RJ, Arthanari H, Lang MJ, Reinherz EL, Wagner G. NMR-directed design of pre-TCRß and pMHC molecules implies a distinct geometry for pre-TCR relative to aßTCR recognition of pMHC. J Biol Chem. 2018 01 19; 293(3):754-766. PMID: 29101227.
    Citations: 3     Fields:    Translation:Cells
  43. Ziarek JJ, Baptista D, Wagner G. Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology. J Mol Med (Berl). 2018 01; 96(1):1-8. PMID: 28643003.
    Citations: 4     Fields:    
  44. Sekiyama N, Boeszoermenyi A, Arthanari H, Wagner G, Léger-Abraham M. 1H, 13C, and 15N backbone chemical shift assignments of 4E-BP144-87 and 4E-BP144-87 bound to eIF4E. Biomol NMR Assign. 2017 Oct; 11(2):187-191. PMID: 28589219.
    Citations:    Fields:    Translation:HumansCells
  45. Coote P, Anklin C, Massefski W, Wagner G, Arthanari H. Rapid convergence of optimal control in NMR using numerically-constructed toggling frames. J Magn Reson. 2017 08; 281:94-103. PMID: 28578162.
    Citations: 4     Fields:    
  46. Hyberts SG, Robson SA, Wagner G. Interpolating and extrapolating with hmsIST: seeking a tmax for optimal sensitivity, resolution and frequency accuracy. J Biomol NMR. 2017 Jun; 68(2):139-154. PMID: 28332026.
    Citations: 9     Fields:    
  47. Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K. Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017 03 14; 18(11):2651-2663. PMID: 28297669.
    Citations: 21     Fields:    Translation:AnimalsCells
  48. Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G. Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nat Methods. 2017 01; 14(1):49-52. PMID: 27869813.
    Citations: 55     Fields:    Translation:HumansCells
  49. Takeuchi K, Arthanari H, Wagner G. Perspective: revisiting the field dependence of TROSY sensitivity. J Biomol NMR. 2016 12; 66(4):221-225. PMID: 27866370.
    Citations: 8     Fields:    
  50. Ilic S, Akabayov SR, Arthanari H, Wagner G, Richardson CC, Akabayov B. Identification of DNA primase inhibitors via a combined fragment-based and virtual screening. Sci Rep. 2016 11 02; 6:36322. PMID: 27805033.
    Citations: 4     Fields:    Translation:HumansCells
  51. Das DK, Mallis RJ, Duke-Cohan JS, Hussey RE, Tetteh PW, Hilton M, Wagner G, Lang MJ, Reinherz EL. Pre-T Cell Receptors (Pre-TCRs) Leverage Vß Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands. J Biol Chem. 2016 Dec 02; 291(49):25292-25305. PMID: 27707880.
    Citations: 19     Fields:    Translation:AnimalsCells
  52. Sun ZJ, Bhanu MK, Allan MG, Arthanari H, Wagner G, Hanna J. Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins. PLoS One. 2016; 11(9):e0163660. PMID: 27662200.
    Citations: 1     Fields:    
  53. Imai S, Kumar P, Hellen CU, D'Souza VM, Wagner G. An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation. Nat Struct Mol Biol. 2016 09; 23(9):859-64. PMID: 27525590.
    Citations: 15     Fields:    Translation:HumansCells
  54. Coote P, Bermel W, Wagner G, Arthanari H. Analytical optimization of active bandwidth and quality factor for TOCSY experiments in NMR spectroscopy. J Biomol NMR. 2016 09; 66(1):9-20. PMID: 27515670.
    Citations: 1     Fields:    
  55. Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K. Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation. Nucleic Acids Res. 2016 Oct 14; 44(18):8704-8713. PMID: 27325740.
    Citations: 12     Fields:    Translation:HumansAnimalsCells