Harvard Catalyst Profiles

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Gerhard Wagner, Ph.D.


Structural Basis of CD2 Signal Transduction Studied by NMR Spectroscopy
Summer, 06/01/99 - 07/30/99

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. S10OD028526 (WAGNER, GERHARD) Jul 15, 2020 - Jul 14, 2021
    600 MHz NMR Spectrometer Console
    Role: Principal Investigator
  2. R01GM129026 (WAGNER, GERHARD) Sep 1, 2018 - Jul 31, 2022
    Next Generation Solution NMR Techniques for GPCR Structure, Dynamics and Function
    Role: Principal Investigator
  3. R01CA200913 (WAGNER, GERHARD) Jul 20, 2016 - Jun 30, 2021
    Roles of Eukaryotic Translation Initiation Factors in Gene Expression
    Role: Principal Investigator
  4. R01AI108718 (WAGNER, GERHARD) Aug 6, 2014 - Jul 31, 2019
    The translation apparatus of Leishmania: from basic analysis to pursuit of novel
    Role: Principal Investigator
  5. R01HL116391 (WAGNER, GERHARD) Jun 3, 2013 - May 31, 2018
    Mechanism and inhibition of SREBP-dependent cholesterol/lipid metabolism
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jayaraj A, Schwanz HA, Spencer DJ, Bhasin S, Hamilton JA, Jayaram B, Goldman AL, Krishna M, Krishnan M, Shah A, Jin Z, Krenzel E, Nair SN, Ramesh S, Guo W, Wagner G, Arthanari H, Peng L, Lawney B, Jasuja R. Allosterically Coupled Multisite Binding of Testosterone to Human Serum Albumin. Endocrinology. 2021 Feb 01; 162(2). PMID: 33125473.
    Citations:    Fields:    
  2. Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening. iScience. 2021 Feb 19; 24(2):102021. PMID: 33426509.
    Citations: 1     
  3. Mizsei R, Li X, Chen WN, Szabo M, Wang JH, Wagner G, Reinherz EL, Mallis RJ. A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes. J Biol Chem. 2021 Jan 04. PMID: 33397788.
    Citations:    Fields:    
  4. Li X, Mizsei R, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL. Pre-T cell receptors topologically sample self-ligands during thymocyte ß-selection. Science. 2021 01 08; 371(6525):181-185. PMID: 33335016.
    Citations:    Fields:    
  5. Behera SP, Dubey A, Chen WN, De Paula VS, Zhang M, Sgourakis NG, Bermel W, Wagner G, Coote PW, Arthanari H. Nearest-neighbor NMR spectroscopy: categorizing spectral peaks by their adjacent nuclei. Nat Commun. 2020 11 03; 11(1):5547. PMID: 33144564.
    Citations: 1     Fields:    Translation:HumansCells
  6. Tyukhtenko S, Ma X, Rajarshi G, Karageorgos I, Anderson KW, Hudgens JW, Guo JJ, Nasr ML, Zvonok N, Vemuri K, Wagner G, Makriyannis A. Conformational gating, dynamics and allostery in human monoacylglycerol lipase. Sci Rep. 2020 10 28; 10(1):18531. PMID: 33116203.
    Citations:    Fields:    Translation:HumansCells
  7. Xu D, Zhao H, Jin M, Zhu H, Shan B, Geng J, Dziedzic SA, Amin P, Mifflin L, Naito MG, Najafov A, Xing J, Yan L, Liu J, Qin Y, Hu X, Wang H, Zhang M, Manuel VJ, Tan L, He Z, Sun ZJ, Lee VMY, Wagner G, Yuan J. Modulating TRADD to restore cellular homeostasis and inhibit apoptosis. Nature. 2020 11; 587(7832):133-138. PMID: 32968279.
    Citations: 1     Fields:    
  8. Gorgulla C, Padmanabha Das KM, Leigh KE, Cespugli M, Fischer PD, Wang ZF, Tesseyre G, Pandita S, Shnapir A, Calderaio A, Gechev M, Rose A, Lewis N, Hutcheson C, Yaffe E, Luxenburg R, Herce HD, Durmaz V, Halazonetis TD, Fackeldey K, Patten JJ, Chuprina A, Dziuba I, Plekhova A, Moroz Y, Radchenko D, Tarkhanova O, Yavnyuk I, Gruber C, Yust R, Payne D, Näär AM, Namchuk MN, Davey RA, Wagner G, Kinney J, Arthanari H. A Multi-Pronged Approach Targeting SARS-CoV-2 Proteins Using Ultra-Large Virtual Screening. ChemRxiv. 2020 Jul 24. PMID: 33200116.
  9. Boeszoermenyi A, Ogórek B, Jain A, Arthanari H, Wagner G. The precious fluorine on the ring: fluorine NMR for biological systems. J Biomol NMR. 2020 Sep; 74(8-9):365-379. PMID: 32651751.
    Citations: 1     Fields:    
  10. Padmanabha Das KM, Shih WM, Wagner G, Nasr ML. Large Nanodiscs: A Potential Game Changer in Structural Biology of Membrane Protein Complexes and Virus Entry. Front Bioeng Biotechnol. 2020; 8:539. PMID: 32596222.
    Citations: 3     
  11. Tupperwar N, Meleppattu S, Shrivastava R, Baron N, Gilad A, Wagner G, Léger-Abraham M, Shapira M. A newly identified Leishmania IF4E-interacting protein, Leish4E-IP2, modulates the activity of cap-binding protein paralogs. Nucleic Acids Res. 2020 05 07; 48(8):4405-4417. PMID: 32232353.
    Citations:    Fields:    Translation:AnimalsCells
  12. Gorgulla C, Boeszoermenyi A, Wang ZF, Fischer PD, Coote PW, Padmanabha Das KM, Malets YS, Radchenko DS, Moroz YS, Scott DA, Fackeldey K, Hoffmann M, Iavniuk I, Wagner G, Arthanari H. An open-source drug discovery platform enables ultra-large virtual screens. Nature. 2020 04; 580(7805):663-668. PMID: 32152607.
    Citations: 16     Fields:    
  13. Böhm R, Amodeo GF, Murlidaran S, Chavali S, Wagner G, Winterhalter M, Brannigan G, Hiller S. The Structural Basis for Low Conductance in the Membrane Protein VDAC upon ß-NADH Binding and Voltage Gating. Structure. 2020 02 04; 28(2):206-214.e4. PMID: 31862297.
    Citations: 4     Fields:    
  14. Wang Y, Kaur P, Sun ZJ, Elbahnasawy MA, Hayati Z, Qiao ZS, Bui NN, Chile C, Nasr ML, Wagner G, Wang JH, Song L, Reinherz EL, Kim M. Topological analysis of the gp41 MPER on lipid bilayers relevant to the metastable HIV-1 envelope prefusion state. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22556-22566. PMID: 31624123.
    Citations: 3     Fields:    Translation:HumansCells
  15. Ling J, Cheloha RW, McCaul N, Sun ZJ, Wagner G, Ploegh HL. A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity. Mol Immunol. 2019 10; 114:513-523. PMID: 31518855.
    Citations: 6     Fields:    Translation:HumansCells
  16. Eddy MT, Yu TY, Wagner G, Griffin RG. Structural characterization of the human membrane protein VDAC2 in lipid bilayers by MAS NMR. J Biomol NMR. 2019 Sep; 73(8-9):451-460. PMID: 31407201.
    Citations:    Fields:    Translation:HumansCells
  17. Tam B, Sherf D, Cohen S, Eisdorfer SA, Perez M, Soffer A, Vilenchik D, Akabayov SR, Wagner G, Akabayov B. Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis. Chem Sci. 2019 Oct 14; 10(38):8764-8767. PMID: 31803448.
  18. Arthanari H, Takeuchi K, Dubey A, Wagner G. Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins. Curr Opin Struct Biol. 2019 10; 58:294-304. PMID: 31327528.
    Citations: 3     Fields:    
  19. Kaptein R, Wagner G. Integrative methods in structural biology. J Biomol NMR. 2019 Jul; 73(6-7):261-263. PMID: 31313058.
    Citations: 2     Fields:    Translation:Humans
  20. Boeszoermenyi A, Chhabra S, Dubey A, Radeva DL, Burdzhiev NT, Chanev CD, Petrov OI, Gelev VM, Zhang M, Anklin C, Kovacs H, Wagner G, Kuprov I, Takeuchi K, Arthanari H. Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics. Nat Methods. 2019 04; 16(4):333-340. PMID: 30858598.
    Citations: 15     Fields:    Translation:Cells
  21. Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL. NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology. J Biomol NMR. 2019 Jul; 73(6-7):319-332. PMID: 30815789.
    Citations: 5     Fields:    Translation:HumansCells
  22. Wagner G. Editorial. J Biomol NMR. 2019 Feb; 73(1-2):1. PMID: 30825034.
    Citations:    Fields:    
  23. Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS. High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3. Sci Rep. 2018 11 30; 8(1):17512. PMID: 30504845.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  24. Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL. The T Cell Antigen Receptor a Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Immunity. 2018 11 20; 49(5):829-841.e6. PMID: 30389415.
    Citations: 11     Fields:    Translation:Cells
  25. Robson S, Arthanari H, Hyberts SG, Wagner G. Nonuniform Sampling for NMR Spectroscopy. Methods Enzymol. 2019; 614:263-291. PMID: 30611427.
    Citations: 4     Fields:    Translation:Humans
  26. O'Day EM, Idos GE, Hill C, Chen JW, Wagner G. Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells. Onco Targets Ther. 2018; 11:6827-6838. PMID: 30349315.
    Citations: 2     
  27. Zhao Z, Zhang M, Hogle JM, Shih WM, Wagner G, Nasr ML. DNA-Corralled Nanodiscs for the Structural and Functional Characterization of Membrane Proteins and Viral Entry. J Am Chem Soc. 2018 08 29; 140(34):10639-10643. PMID: 30094995.
    Citations: 7     Fields:    Translation:HumansCells
  28. Coote PW, Robson SA, Dubey A, Boeszoermenyi A, Zhao M, Wagner G, Arthanari H. Optimal control theory enables homonuclear decoupling without Bloch-Siegert shifts in NMR spectroscopy. Nat Commun. 2018 08 01; 9(1):3014. PMID: 30069002.
    Citations: 4     Fields:    Translation:Humans
  29. Meleppattu S, Arthanari H, Zinoviev A, Boeszoermenyi A, Wagner G, Shapira M, Léger-Abraham M. Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major. Nucleic Acids Res. 2018 04 20; 46(7):3791-3801. PMID: 29562352.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  30. Nasr ML, Wagner G. Covalently circularized nanodiscs; challenges and applications. Curr Opin Struct Biol. 2018 08; 51:129-134. PMID: 29677570.
    Citations: 7     Fields:    Translation:Cells
  31. Chhabra S, Fischer P, Takeuchi K, Dubey A, Ziarek JJ, Boeszoermenyi A, Mathieu D, Bermel W, Davey NE, Wagner G, Arthanari H. 15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):E1710-E1719. PMID: 29432148.
    Citations: 4     Fields:    Translation:Cells
  32. Robson SA, Takeuchi K, Boeszoermenyi A, Coote PW, Dubey A, Hyberts S, Wagner G, Arthanari H. Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment. Nat Commun. 2018 01 24; 9(1):356. PMID: 29367739.
    Citations: 5     Fields:    Translation:Cells
  33. Yi T, Wagner G. Cytocapsular tubes conduct cell translocation. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):E1137-E1146. PMID: 29339492.
    Citations:    Fields:    Translation:HumansAnimalsCells
  34. Hagn F, Nasr ML, Wagner G. Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Nat Protoc. 2018 Jan; 13(1):79-98. PMID: 29215632.
    Citations: 26     Fields:    
  35. Takeuchi K, Arthanari H, Shimada I, Wagner G. Erratum to: Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR. J Biomol NMR. 2017 12; 69(4):245. PMID: 29230599.
    Citations:    Fields:    
  36. Mallis RJ, Arthanari H, Lang MJ, Reinherz EL, Wagner G. NMR-directed design of pre-TCRß and pMHC molecules implies a distinct geometry for pre-TCR relative to aßTCR recognition of pMHC. J Biol Chem. 2018 01 19; 293(3):754-766. PMID: 29101227.
    Citations: 1     Fields:    Translation:Cells
  37. Ziarek JJ, Baptista D, Wagner G. Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology. J Mol Med (Berl). 2018 01; 96(1):1-8. PMID: 28643003.
    Citations: 3     Fields:    
  38. Sekiyama N, Boeszoermenyi A, Arthanari H, Wagner G, Léger-Abraham M. 1H, 13C, and 15N backbone chemical shift assignments of 4E-BP144-87 and 4E-BP144-87 bound to eIF4E. Biomol NMR Assign. 2017 Oct; 11(2):187-191. PMID: 28589219.
    Citations:    Fields:    Translation:HumansCells
  39. Coote P, Anklin C, Massefski W, Wagner G, Arthanari H. Rapid convergence of optimal control in NMR using numerically-constructed toggling frames. J Magn Reson. 2017 08; 281:94-103. PMID: 28578162.
    Citations: 3     Fields:    
  40. Hyberts SG, Robson SA, Wagner G. Interpolating and extrapolating with hmsIST: seeking a tmax for optimal sensitivity, resolution and frequency accuracy. J Biomol NMR. 2017 Jun; 68(2):139-154. PMID: 28332026.
    Citations: 9     Fields:    
  41. Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K. Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017 03 14; 18(11):2651-2663. PMID: 28297669.
    Citations: 17     Fields:    Translation:AnimalsCells
  42. Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G. Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nat Methods. 2017 01; 14(1):49-52. PMID: 27869813.
    Citations: 47     Fields:    Translation:HumansCells
  43. Takeuchi K, Arthanari H, Wagner G. Perspective: revisiting the field dependence of TROSY sensitivity. J Biomol NMR. 2016 12; 66(4):221-225. PMID: 27866370.
    Citations: 7     Fields:    
  44. Ilic S, Akabayov SR, Arthanari H, Wagner G, Richardson CC, Akabayov B. Identification of DNA primase inhibitors via a combined fragment-based and virtual screening. Sci Rep. 2016 11 02; 6:36322. PMID: 27805033.
    Citations: 4     Fields:    Translation:HumansCells
  45. Das DK, Mallis RJ, Duke-Cohan JS, Hussey RE, Tetteh PW, Hilton M, Wagner G, Lang MJ, Reinherz EL. Pre-T Cell Receptors (Pre-TCRs) Leverage Vß Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands. J Biol Chem. 2016 Dec 02; 291(49):25292-25305. PMID: 27707880.
    Citations: 15     Fields:    Translation:AnimalsCells
  46. Sun ZJ, Bhanu MK, Allan MG, Arthanari H, Wagner G, Hanna J. Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins. PLoS One. 2016; 11(9):e0163660. PMID: 27662200.
    Citations: 1     Fields:    
  47. Imai S, Kumar P, Hellen CU, D'Souza VM, Wagner G. An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation. Nat Struct Mol Biol. 2016 09; 23(9):859-64. PMID: 27525590.
    Citations: 14     Fields:    Translation:HumansCells
  48. Coote P, Bermel W, Wagner G, Arthanari H. Analytical optimization of active bandwidth and quality factor for TOCSY experiments in NMR spectroscopy. J Biomol NMR. 2016 09; 66(1):9-20. PMID: 27515670.
    Citations: 1     Fields:    
  49. Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K. Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation. Nucleic Acids Res. 2016 Oct 14; 44(18):8704-8713. PMID: 27325740.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  50. Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G, Hagn F. Conformational dynamics of a G-protein a subunit is tightly regulated by nucleotide binding. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3629-38. PMID: 27298341.
    Citations: 24     Fields:    Translation:HumansCells
  51. Salvi N, Papadopoulos E, Blackledge M, Wagner G. The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex. Angew Chem Int Ed Engl. 2016 06 13; 55(25):7176-9. PMID: 27162083.
    Citations: 3     Fields:    Translation:HumansCells
  52. Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M, Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Näär AM, Arthanari H. Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature. 2016 Feb 25; 530(7591):485-9. PMID: 26886795.
    Citations: 38     Fields:    Translation:AnimalsCells
  53. Takeuchi K, Arthanari H, Imai M, Wagner G, Shimada I. Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions. J Biomol NMR. 2016 Feb; 64(2):143-51. PMID: 26800993.
    Citations: 12     Fields:    Translation:Cells
  54. Viegas A, Viennet T, Yu TY, Schumann F, Bermel W, Wagner G, Etzkorn M. UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection. J Biomol NMR. 2016 Jan; 64(1):9-15. PMID: 26728075.
    Citations: 6     Fields:    
  55. Takeuchi K, Arthanari H, Shimada I, Wagner G. Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR. J Biomol NMR. 2015 Dec; 63(4):323-331. PMID: 26497830.
    Citations: 17     Fields:    Translation:Cells
  56. Nartey W, Basak S, Kamariah N, Manimekalai MS, Robson S, Wagner G, Eisenhaber B, Eisenhaber F, Grüber G. NMR studies reveal a novel grab and release mechanism for efficient catalysis of the bacterial 2-Cys peroxiredoxin machinery. FEBS J. 2015 Dec; 282(23):4620-38. PMID: 26402142.
    Citations: 4     Fields:    Translation:Cells
  57. Linser R, Salvi N, Briones R, Rovó P, de Groot BL, Wagner G. The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):12390-5. PMID: 26392539.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  58. Raschle T, Lin C, Jungmann R, Shih WM, Wagner G. Controlled Co-reconstitution of Multiple Membrane Proteins in Lipid Bilayer Nanodiscs Using DNA as a Scaffold. ACS Chem Biol. 2015 Nov 20; 10(11):2448-54. PMID: 26356202.
    Citations: 7     Fields:    Translation:Cells
  59. Boeszoermenyi A, Nagy HM, Arthanari H, Pillip CJ, Lindermuth H, Luna RE, Wagner G, Zechner R, Zangger K, Oberer M. Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring. J Biol Chem. 2015 Oct 30; 290(44):26361-72. PMID: 26350461.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  60. Brazin KN, Mallis RJ, Das DK, Feng Y, Hwang W, Wang JH, Wagner G, Lang MJ, Reinherz EL. Structural Features of the aßTCR Mechanotransduction Apparatus That Promote pMHC Discrimination. Front Immunol. 2015; 6:441. PMID: 26388869.
    Citations: 25     Fields:    
  61. Mallis RJ, Reinherz EL, Wagner G, Arthanari H. Backbone resonance assignment of N15, N30 and D10 T cell receptor ß subunits. Biomol NMR Assign. 2016 Apr; 10(1):35-9. PMID: 26275917.
    Citations: 2     Fields:    Translation:Cells
  62. Sekiyama N, Arthanari H, Papadopoulos E, Rodriguez-Mias RA, Wagner G, Léger-Abraham M. Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4036-45. PMID: 26170285.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  63. Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H. Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9010-5. PMID: 26150520.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  64. Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL. Pre-TCR ligand binding impacts thymocyte development before aßTCR expression. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8373-8. PMID: 26056289.
    Citations: 25     Fields:    Translation:AnimalsCells
  65. O'Day E, Le MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-22. PMID: 26045559.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  66. Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Güttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Commun. 2015 May 28; 6:7194. PMID: 26018492.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  67. Milbradt AG, Arthanari H, Takeuchi K, Boeszoermenyi A, Hagn F, Wagner G. Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY. J Biomol NMR. 2015 Jul; 62(3):291-301. PMID: 25957757.
    Citations: 9     Fields:    
  68. Kaptein R, Wagner G. NMR studies of membrane proteins. J Biomol NMR. 2015 Apr; 61(3-4):181-4. PMID: 25840906.
    Citations: 2     Fields:    Translation:Cells
  69. Eddy MT, Su Y, Silvers R, Andreas L, Clark L, Wagner G, Pintacuda G, Emsley L, Griffin RG. Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR. J Biomol NMR. 2015 Apr; 61(3-4):299-310. PMID: 25634301.
    Citations: 12     Fields:    Translation:HumansCells
  70. Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ. Force-dependent transition in the T-cell receptor ß-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1517-22. PMID: 25605925.
    Citations: 75     Fields:    Translation:Cells
  71. Eddy MT, Andreas L, Teijido O, Su Y, Clark L, Noskov SY, Wagner G, Rostovtseva TK, Griffin RG. Magic angle spinning nuclear magnetic resonance characterization of voltage-dependent anion channel gating in two-dimensional lipid crystalline bilayers. Biochemistry. 2015 Feb 03; 54(4):994-1005. PMID: 25545271.
    Citations: 10     Fields:    Translation:HumansCells
  72. Hagn F, Wagner G. Structure refinement and membrane positioning of selectively labeled OmpX in phospholipid nanodiscs. J Biomol NMR. 2015 Apr; 61(3-4):249-60. PMID: 25430058.
    Citations: 14     Fields:    Translation:Cells
  73. Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P. G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18201-6. PMID: 25404306.
    Citations: 96     Fields:    Translation:HumansCells
  74. Akabayov SR, Akabayov B, Wagner G. Human translation initiation factor eIF4G1 possesses a low-affinity ATP binding site facing the ATP-binding cleft of eIF4A in the eIF4G/eIF4A complex. Biochemistry. 2014 Oct 21; 53(41):6422-5. PMID: 25255371.
    Citations: 1     Fields:    Translation:HumansCells
  75. Wommack AJ, Ziarek JJ, Tomaras J, Chileveru HR, Zhang Y, Wagner G, Nolan EM. Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. J Am Chem Soc. 2014 Oct 01; 136(39):13494-7. PMID: 25181039.
    Citations: 9     Fields:    Translation:HumansCells
  76. Takeuchi K, Sun ZY, Li S, Gal M, Wagner G. NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states. Biomol NMR Assign. 2015 Apr; 9(1):201-5. PMID: 25209144.
    Citations: 2     Fields:    Translation:HumansCells
  77. Hiraishi H, Oatman J, Haller SL, Blunk L, McGivern B, Morris J, Papadopoulos E, Gutierrez W, Gordon M, Bokhari W, Ikeda Y, Miles D, Fellers J, Asano M, Wagner G, Tazi L, Rothenburg S, Brown SJ, Asano K. Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression. Nucleic Acids Res. 2014; 42(16):10321-30. PMID: 25147208.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  78. Yi T, Kabha E, Papadopoulos E, Wagner G. 4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis. Oncotarget. 2014 Aug 15; 5(15):6028-37. PMID: 25115391.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  79. Linser R, Bardiaux B, Andreas LB, Hyberts SG, Morris VK, Pintacuda G, Sunde M, Kwan AH, Wagner G. Solid-state NMR structure determination from diagonal-compensated, sparsely nonuniform-sampled 4D proton-proton restraints. J Am Chem Soc. 2014 Aug 06; 136(31):11002-10. PMID: 24988008.
    Citations: 15     Fields:    Translation:Cells
  80. Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G. Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3187-95. PMID: 25049413.
    Citations: 26     Fields:    Translation:HumansCells
  81. Coote P, Leigh KE, Yu TY, Khaneja N, Wagner G, Arthanari H. A new broadband homonuclear mixing pulse for NMR with low applied power. J Chem Phys. 2014 Jul 14; 141(2):024201. PMID: 25028012.
    Citations: 1     Fields:    
  82. Linser R, Gelev V, Hagn F, Arthanari H, Hyberts SG, Wagner G. Selective methyl labeling of eukaryotic membrane proteins using cell-free expression. J Am Chem Soc. 2014 Aug 13; 136(32):11308-10. PMID: 24937763.
    Citations: 8     Fields:    Translation:HumansCells
  83. Gal M, Li S, Luna RE, Takeuchi K, Wagner G. The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain. Structure. 2014 Jul 08; 22(7):1016-27. PMID: 24954618.
    Citations: 5     Fields:    Translation:HumansCells
  84. Edmonds KA, Wagner G. (1)H, (13)C, and (15)N backbone and sidechain chemical shift assignments for the HEAT2 domain of human eIF4GI. Biomol NMR Assign. 2015 Apr; 9(1):157-60. PMID: 24929364.
    Citations:    Fields:    Translation:HumansCells
  85. Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M. Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction. J Med Chem. 2014 Jun 26; 57(12):5094-111. PMID: 24827861.
    Citations: 8     Fields:    Translation:HumansCells
  86. Elter S, Raschle T, Arens S, Viegas A, Gelev V, Etzkorn M, Wagner G. The use of amphipols for NMR structural characterization of 7-TM proteins. J Membr Biol. 2014 Oct; 247(9-10):957-64. PMID: 24858950.
    Citations: 8     Fields:    Translation:Cells
  87. Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL. Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2014 Jul 04; 289(27):18880-92. PMID: 24849600.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  88. Avnir Y, Tallarico AS, Zhu Q, Bennett AS, Connelly G, Sheehan J, Sui J, Fahmy A, Huang CY, Cadwell G, Bankston LA, McGuire AT, Stamatatos L, Wagner G, Liddington RC, Marasco WA. Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses. PLoS Pathog. 2014 May; 10(5):e1004103. PMID: 24788925.
    Citations: 43     Fields:    Translation:HumansCells
  89. Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G. Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2182-90. PMID: 24782546.