Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Gerhard Wagner, Ph.D.

Title
Institution
Department
Address
Phone
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Mentoring
completed student projects
Structural Basis of CD2 Signal Transduction Studied by NMR Spectroscopy
Summer, 06/01/99 - 07/30/99

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01GM129026 (WAGNER, GERHARD) Sep 1, 2018 - Jul 31, 2022
    NIH/NIGMS
    Next Generation Solution NMR Techniques for GPCR Structure, Dynamics and Function
    Role: Principal Investigator
  2. R01CA200913 (WAGNER, GERHARD) Aug 1, 2017 - Jun 30, 2021
    NIH/NCI
    Roles of Eukaryotic Translation Initiation Factors in Gene Expression
    Role: Principal Investigator
  3. R01AI108718 (WAGNER, GERHARD) Aug 6, 2014 - Jul 31, 2018
    NIH/NIAID
    The translation apparatus of Leishmania: from basic analysis to pursuit of novel
    Role: Principal Investigator
  4. R01HL116391 (WAGNER, GERHARD) Jun 3, 2013 - May 31, 2017
    NIH/NHLBI
    Mechanism and inhibition of SREBP-dependent cholesterol/lipid metabolism
    Role: Principal Investigator
  5. S10RR026417 (WAGNER, GERHARD) Nov 20, 2009 - Nov 19, 2011
    NIH/NCRR
    800 MHz Triple Resonance Observe (TXO) Detection CryoProbe
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tupperwar N, Meleppattu S, Shrivastava R, Baron N, Gilad A, Wagner G, Léger-Abraham M, Shapira M. A newly identified Leishmania IF4E-interacting protein, Leish4E-IP2, modulates the activity of cap-binding protein paralogs. Nucleic Acids Res. 2020 May 07; 48(8):4405-4417. PMID: 32232353.
    Citations:    
  2. Gorgulla C, Boeszoermenyi A, Wang ZF, Fischer PD, Coote PW, Padmanabha Das KM, Malets YS, Radchenko DS, Moroz YS, Scott DA, Fackeldey K, Hoffmann M, Iavniuk I, Wagner G, Arthanari H. An open-source drug discovery platform enables ultra-large virtual screens. Nature. 2020 Apr; 580(7805):663-668. PMID: 32152607.
    Citations:    
  3. Böhm R, Amodeo GF, Murlidaran S, Chavali S, Wagner G, Winterhalter M, Brannigan G, Hiller S. The Structural Basis for Low Conductance in the Membrane Protein VDAC upon ß-NADH Binding and Voltage Gating. Structure. 2020 Feb 04; 28(2):206-214.e4. PMID: 31862297.
    Citations:    
  4. Wang Y, Kaur P, Sun ZJ, Elbahnasawy MA, Hayati Z, Qiao ZS, Bui NN, Chile C, Nasr ML, Wagner G, Wang JH, Song L, Reinherz EL, Kim M. Topological analysis of the gp41 MPER on lipid bilayers relevant to the metastable HIV-1 envelope prefusion state. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22556-22566. PMID: 31624123.
    Citations:    
  5. Ling J, Cheloha RW, McCaul N, Sun ZJ, Wagner G, Ploegh HL. A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity. Mol Immunol. 2019 10; 114:513-523. PMID: 31518855.
    Citations:    
  6. Eddy MT, Yu TY, Wagner G, Griffin RG. Structural characterization of the human membrane protein VDAC2 in lipid bilayers by MAS NMR. J Biomol NMR. 2019 Sep; 73(8-9):451-460. PMID: 31407201.
    Citations:    
  7. Tam B, Sherf D, Cohen S, Eisdorfer SA, Perez M, Soffer A, Vilenchik D, Akabayov SR, Wagner G, Akabayov B. Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis. Chem Sci. 2019 Oct 14; 10(38):8764-8767. PMID: 31803448.
    Citations:    
  8. Arthanari H, Takeuchi K, Dubey A, Wagner G. Emerging solution NMR methods to illuminate the structural and dynamic properties of proteins. Curr Opin Struct Biol. 2019 10; 58:294-304. PMID: 31327528.
    Citations:    
  9. Kaptein R, Wagner G. Integrative methods in structural biology. J Biomol NMR. 2019 Jul; 73(6-7):261-263. PMID: 31313058.
    Citations:    
  10. Boeszoermenyi A, Chhabra S, Dubey A, Radeva DL, Burdzhiev NT, Chanev CD, Petrov OI, Gelev VM, Zhang M, Anklin C, Kovacs H, Wagner G, Kuprov I, Takeuchi K, Arthanari H. Aromatic 19F-13C TROSY: a background-free approach to probe biomolecular structure, function, and dynamics. Nat Methods. 2019 04; 16(4):333-340. PMID: 30858598.
    Citations:    
  11. Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL. NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology. J Biomol NMR. 2019 Jul; 73(6-7):319-332. PMID: 30815789.
    Citations:    
  12. Wagner G. Editorial. J Biomol NMR. 2019 Feb; 73(1-2):1. PMID: 30825034.
    Citations:    
  13. Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS. High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3. Sci Rep. 2018 11 30; 8(1):17512. PMID: 30504845.
    Citations:    
  14. Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL. The T Cell Antigen Receptor a Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Immunity. 2018 11 20; 49(5):829-841.e6. PMID: 30389415.
    Citations:    Fields:    
  15. Robson S, Arthanari H, Hyberts SG, Wagner G. Nonuniform Sampling for NMR Spectroscopy. Methods Enzymol. 2019; 614:263-291. PMID: 30611427.
    Citations:    Fields:    
  16. O'Day EM, Idos GE, Hill C, Chen JW, Wagner G. Cytidine monophosphate N-acetylneuraminic acid synthetase enhances invasion of human triple-negative breast cancer cells. Onco Targets Ther. 2018; 11:6827-6838. PMID: 30349315.
    Citations:    
  17. Zhao Z, Zhang M, Hogle JM, Shih WM, Wagner G, Nasr ML. DNA-Corralled Nanodiscs for the Structural and Functional Characterization of Membrane Proteins and Viral Entry. J Am Chem Soc. 2018 08 29; 140(34):10639-10643. PMID: 30094995.
    Citations:    Fields:    
  18. Coote PW, Robson SA, Dubey A, Boeszoermenyi A, Zhao M, Wagner G, Arthanari H. Optimal control theory enables homonuclear decoupling without Bloch-Siegert shifts in NMR spectroscopy. Nat Commun. 2018 08 01; 9(1):3014. PMID: 30069002.
    Citations:    Fields:    Translation:Humans
  19. Meleppattu S, Arthanari H, Zinoviev A, Boeszoermenyi A, Wagner G, Shapira M, Léger-Abraham M. Structural basis for LeishIF4E-1 modulation by an interacting protein in the human parasite Leishmania major. Nucleic Acids Res. 2018 04 20; 46(7):3791-3801. PMID: 29562352.
    Citations: 1     Fields:    
  20. Nasr ML, Wagner G. Covalently circularized nanodiscs; challenges and applications. Curr Opin Struct Biol. 2018 08; 51:129-134. PMID: 29677570.
    Citations: 2     Fields:    
  21. Chhabra S, Fischer P, Takeuchi K, Dubey A, Ziarek JJ, Boeszoermenyi A, Mathieu D, Bermel W, Davey NE, Wagner G, Arthanari H. 15N detection harnesses the slow relaxation property of nitrogen: Delivering enhanced resolution for intrinsically disordered proteins. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):E1710-E1719. PMID: 29432148.
    Citations:    Fields:    Translation:Cells
  22. Robson SA, Takeuchi K, Boeszoermenyi A, Coote PW, Dubey A, Hyberts S, Wagner G, Arthanari H. Mixed pyruvate labeling enables backbone resonance assignment of large proteins using a single experiment. Nat Commun. 2018 01 24; 9(1):356. PMID: 29367739.
    Citations:    
  23. Yi T, Wagner G. Cytocapsular tubes conduct cell translocation. Proc Natl Acad Sci U S A. 2018 02 06; 115(6):E1137-E1146. PMID: 29339492.
    Citations:    Fields:    Translation:HumansAnimalsCells
  24. Hagn F, Nasr ML, Wagner G. Assembly of phospholipid nanodiscs of controlled size for structural studies of membrane proteins by NMR. Nat Protoc. 2018 Jan; 13(1):79-98. PMID: 29215632.
    Citations: 4     Fields:    
  25. Takeuchi K, Arthanari H, Shimada I, Wagner G. Erratum to: Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR. J Biomol NMR. 2017 12; 69(4):245. PMID: 29230599.
    Citations:    Fields:    
  26. Mallis RJ, Arthanari H, Lang MJ, Reinherz EL, Wagner G. NMR-directed design of pre-TCRß and pMHC molecules implies a distinct geometry for pre-TCR relative to aßTCR recognition of pMHC. J Biol Chem. 2018 01 19; 293(3):754-766. PMID: 29101227.
    Citations:    Fields:    Translation:Cells
  27. Ziarek JJ, Baptista D, Wagner G. Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology. J Mol Med (Berl). 2018 01; 96(1):1-8. PMID: 28643003.
    Citations:    Fields:    
  28. Sekiyama N, Boeszoermenyi A, Arthanari H, Wagner G, Léger-Abraham M. 1H, 13C, and 15N backbone chemical shift assignments of 4E-BP144-87 and 4E-BP144-87 bound to eIF4E. Biomol NMR Assign. 2017 Oct; 11(2):187-191. PMID: 28589219.
    Citations:    Fields:    Translation:HumansCells
  29. Coote P, Anklin C, Massefski W, Wagner G, Arthanari H. Rapid convergence of optimal control in NMR using numerically-constructed toggling frames. J Magn Reson. 2017 08; 281:94-103. PMID: 28578162.
    Citations:    Fields:    
  30. Hyberts SG, Robson SA, Wagner G. Interpolating and extrapolating with hmsIST: seeking a tmax for optimal sensitivity, resolution and frequency accuracy. J Biomol NMR. 2017 Jun; 68(2):139-154. PMID: 28332026.
    Citations: 3     Fields:    
  31. Obayashi E, Luna RE, Nagata T, Martin-Marcos P, Hiraishi H, Singh CR, Erzberger JP, Zhang F, Arthanari H, Morris J, Pellarin R, Moore C, Harmon I, Papadopoulos E, Yoshida H, Nasr ML, Unzai S, Thompson B, Aube E, Hustak S, Stengel F, Dagraca E, Ananbandam A, Gao P, Urano T, Hinnebusch AG, Wagner G, Asano K. Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017 03 14; 18(11):2651-2663. PMID: 28297669.
    Citations: 7     Fields:    Translation:AnimalsCells
  32. Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G. Covalently circularized nanodiscs for studying membrane proteins and viral entry. Nat Methods. 2017 01; 14(1):49-52. PMID: 27869813.
    Citations: 13     Fields:    Translation:HumansCells
  33. Takeuchi K, Arthanari H, Wagner G. Perspective: revisiting the field dependence of TROSY sensitivity. J Biomol NMR. 2016 12; 66(4):221-225. PMID: 27866370.
    Citations: 3     Fields:    
  34. Ilic S, Akabayov SR, Arthanari H, Wagner G, Richardson CC, Akabayov B. Identification of DNA primase inhibitors via a combined fragment-based and virtual screening. Sci Rep. 2016 11 02; 6:36322. PMID: 27805033.
    Citations: 2     Fields:    Translation:HumansCells
  35. Das DK, Mallis RJ, Duke-Cohan JS, Hussey RE, Tetteh PW, Hilton M, Wagner G, Lang MJ, Reinherz EL. Pre-T Cell Receptors (Pre-TCRs) Leverage Vß Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands. J Biol Chem. 2016 Dec 02; 291(49):25292-25305. PMID: 27707880.
    Citations: 6     Fields:    Translation:AnimalsCells
  36. Sun ZJ, Bhanu MK, Allan MG, Arthanari H, Wagner G, Hanna J. Solution Structure of the Cuz1 AN1 Zinc Finger Domain: An Exposed LDFLP Motif Defines a Subfamily of AN1 Proteins. PLoS One. 2016; 11(9):e0163660. PMID: 27662200.
    Citations:    Fields:    
  37. Imai S, Kumar P, Hellen CU, D'Souza VM, Wagner G. An accurately preorganized IRES RNA structure enables eIF4G capture for initiation of viral translation. Nat Struct Mol Biol. 2016 09; 23(9):859-64. PMID: 27525590.
    Citations: 4     Fields:    Translation:HumansCells
  38. Coote P, Bermel W, Wagner G, Arthanari H. Analytical optimization of active bandwidth and quality factor for TOCSY experiments in NMR spectroscopy. J Biomol NMR. 2016 09; 66(1):9-20. PMID: 27515670.
    Citations:    Fields:    
  39. Kozel C, Thompson B, Hustak S, Moore C, Nakashima A, Singh CR, Reid M, Cox C, Papadopoulos E, Luna RE, Anderson A, Tagami H, Hiraishi H, Slone EA, Yoshino KI, Asano M, Gillaspie S, Nietfeld J, Perchellet JP, Rothenburg S, Masai H, Wagner G, Beeser A, Kikkawa U, Fleming SD, Asano K. Overexpression of eIF5 or its protein mimic 5MP perturbs eIF2 function and induces ATF4 translation through delayed re-initiation. Nucleic Acids Res. 2016 Oct 14; 44(18):8704-8713. PMID: 27325740.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  40. Goricanec D, Stehle R, Egloff P, Grigoriu S, Plückthun A, Wagner G, Hagn F. Conformational dynamics of a G-protein a subunit is tightly regulated by nucleotide binding. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):E3629-38. PMID: 27298341.
    Citations: 12     Fields:    Translation:HumansCells
  41. Salvi N, Papadopoulos E, Blackledge M, Wagner G. The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex. Angew Chem Int Ed Engl. 2016 06 13; 55(25):7176-9. PMID: 27162083.
    Citations:    Fields:    Translation:HumansCells
  42. Nishikawa JL, Boeszoermenyi A, Vale-Silva LA, Torelli R, Posteraro B, Sohn YJ, Ji F, Gelev V, Sanglard D, Sanguinetti M, Sadreyev RI, Mukherjee G, Bhyravabhotla J, Buhrlage SJ, Gray NS, Wagner G, Näär AM, Arthanari H. Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature. 2016 Feb 25; 530(7591):485-9. PMID: 26886795.
    Citations: 17     Fields:    Translation:AnimalsCells
  43. Takeuchi K, Arthanari H, Imai M, Wagner G, Shimada I. Nitrogen-detected TROSY yields comparable sensitivity to proton-detected TROSY for non-deuterated, large proteins under physiological salt conditions. J Biomol NMR. 2016 Feb; 64(2):143-51. PMID: 26800993.
    Citations: 6     Fields:    Translation:Cells
  44. Viegas A, Viennet T, Yu TY, Schumann F, Bermel W, Wagner G, Etzkorn M. UTOPIA NMR: activating unexploited magnetization using interleaved low-gamma detection. J Biomol NMR. 2016 Jan; 64(1):9-15. PMID: 26728075.
    Citations: 1     Fields:    
  45. Takeuchi K, Arthanari H, Shimada I, Wagner G. Nitrogen detected TROSY at high field yields high resolution and sensitivity for protein NMR. J Biomol NMR. 2015 Dec; 63(4):323-331. PMID: 26497830.
    Citations: 9     Fields:    Translation:Cells
  46. Nartey W, Basak S, Kamariah N, Manimekalai MS, Robson S, Wagner G, Eisenhaber B, Eisenhaber F, Grüber G. NMR studies reveal a novel grab and release mechanism for efficient catalysis of the bacterial 2-Cys peroxiredoxin machinery. FEBS J. 2015 Dec; 282(23):4620-38. PMID: 26402142.
    Citations: 3     Fields:    Translation:Cells
  47. Linser R, Salvi N, Briones R, Rovó P, de Groot BL, Wagner G. The membrane anchor of the transcriptional activator SREBP is characterized by intrinsic conformational flexibility. Proc Natl Acad Sci U S A. 2015 Oct 06; 112(40):12390-5. PMID: 26392539.
    Citations:    Fields:    Translation:HumansAnimalsCells
  48. Raschle T, Lin C, Jungmann R, Shih WM, Wagner G. Controlled Co-reconstitution of Multiple Membrane Proteins in Lipid Bilayer Nanodiscs Using DNA as a Scaffold. ACS Chem Biol. 2015 Nov 20; 10(11):2448-54. PMID: 26356202.
    Citations: 4     Fields:    Translation:Cells
  49. Boeszoermenyi A, Nagy HM, Arthanari H, Pillip CJ, Lindermuth H, Luna RE, Wagner G, Zechner R, Zangger K, Oberer M. Structure of a CGI-58 motif provides the molecular basis of lipid droplet anchoring. J Biol Chem. 2015 Oct 30; 290(44):26361-72. PMID: 26350461.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  50. Brazin KN, Mallis RJ, Das DK, Feng Y, Hwang W, Wang JH, Wagner G, Lang MJ, Reinherz EL. Structural Features of the aßTCR Mechanotransduction Apparatus That Promote pMHC Discrimination. Front Immunol. 2015; 6:441. PMID: 26388869.
    Citations: 9     
  51. Mallis RJ, Reinherz EL, Wagner G, Arthanari H. Backbone resonance assignment of N15, N30 and D10 T cell receptor ß subunits. Biomol NMR Assign. 2016 Apr; 10(1):35-9. PMID: 26275917.
    Citations:    Fields:    Translation:Cells
  52. Sekiyama N, Arthanari H, Papadopoulos E, Rodriguez-Mias RA, Wagner G, Léger-Abraham M. Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proc Natl Acad Sci U S A. 2015 Jul 28; 112(30):E4036-45. PMID: 26170285.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  53. Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H. Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9010-5. PMID: 26150520.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  54. Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL. Pre-TCR ligand binding impacts thymocyte development before aßTCR expression. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8373-8. PMID: 26056289.
    Citations: 15     Fields:    Translation:AnimalsCells
  55. O'Day E, Le MT, Imai S, Tan SM, Kirchner R, Arthanari H, Hofmann O, Wagner G, Lieberman J. An RNA-binding Protein, Lin28, Recognizes and Remodels G-quartets in the MicroRNAs (miRNAs) and mRNAs It Regulates. J Biol Chem. 2015 Jul 17; 290(29):17909-22. PMID: 26045559.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  56. Yi T, Arthanari H, Akabayov B, Song H, Papadopoulos E, Qi HH, Jedrychowski M, Güttler T, Guo C, Luna RE, Gygi SP, Huang SA, Wagner G. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Commun. 2015 May 28; 6:7194. PMID: 26018492.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  57. Milbradt AG, Arthanari H, Takeuchi K, Boeszoermenyi A, Hagn F, Wagner G. Increased resolution of aromatic cross peaks using alternate 13C labeling and TROSY. J Biomol NMR. 2015 Jul; 62(3):291-301. PMID: 25957757.
    Citations: 5     Fields:    
  58. Kaptein R, Wagner G. NMR studies of membrane proteins. J Biomol NMR. 2015 Apr; 61(3-4):181-4. PMID: 25840906.
    Citations: 1     Fields:    Translation:Cells
  59. Eddy MT, Su Y, Silvers R, Andreas L, Clark L, Wagner G, Pintacuda G, Emsley L, Griffin RG. Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR. J Biomol NMR. 2015 Apr; 61(3-4):299-310. PMID: 25634301.
    Citations: 9     Fields:    Translation:HumansCells
  60. Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ. Force-dependent transition in the T-cell receptor ß-subunit allosterically regulates peptide discrimination and pMHC bond lifetime. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):1517-22. PMID: 25605925.
    Citations: 40     Fields:    Translation:Cells
  61. Eddy MT, Andreas L, Teijido O, Su Y, Clark L, Noskov SY, Wagner G, Rostovtseva TK, Griffin RG. Magic angle spinning nuclear magnetic resonance characterization of voltage-dependent anion channel gating in two-dimensional lipid crystalline bilayers. Biochemistry. 2015 Feb 03; 54(4):994-1005. PMID: 25545271.
    Citations: 6     Fields:    Translation:HumansCells
  62. Hagn F, Wagner G. Structure refinement and membrane positioning of selectively labeled OmpX in phospholipid nanodiscs. J Biomol NMR. 2015 Apr; 61(3-4):249-60. PMID: 25430058.
    Citations: 6     Fields:    Translation:Cells
  63. Ivanov P, O'Day E, Emara MM, Wagner G, Lieberman J, Anderson P. G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18201-6. PMID: 25404306.
    Citations: 44     Fields:    Translation:HumansCells
  64. Akabayov SR, Akabayov B, Wagner G. Human translation initiation factor eIF4G1 possesses a low-affinity ATP binding site facing the ATP-binding cleft of eIF4A in the eIF4G/eIF4A complex. Biochemistry. 2014 Oct 21; 53(41):6422-5. PMID: 25255371.
    Citations:    Fields:    Translation:HumansCells
  65. Wommack AJ, Ziarek JJ, Tomaras J, Chileveru HR, Zhang Y, Wagner G, Nolan EM. Discovery and characterization of a disulfide-locked C(2)-symmetric defensin peptide. J Am Chem Soc. 2014 Oct 01; 136(39):13494-7. PMID: 25181039.
    Citations: 8     Fields:    Translation:HumansCells
  66. Takeuchi K, Sun ZY, Li S, Gal M, Wagner G. NMR resonance assignments of the catalytic domain of human serine/threonine phosphatase calcineurin in unligated and PVIVIT-peptide-bound states. Biomol NMR Assign. 2015 Apr; 9(1):201-5. PMID: 25209144.
    Citations: 1     Fields:    Translation:HumansCells
  67. Hiraishi H, Oatman J, Haller SL, Blunk L, McGivern B, Morris J, Papadopoulos E, Gutierrez W, Gordon M, Bokhari W, Ikeda Y, Miles D, Fellers J, Asano M, Wagner G, Tazi L, Rothenburg S, Brown SJ, Asano K. Essential role of eIF5-mimic protein in animal development is linked to control of ATF4 expression. Nucleic Acids Res. 2014; 42(16):10321-30. PMID: 25147208.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  68. Yi T, Kabha E, Papadopoulos E, Wagner G. 4EGI-1 targets breast cancer stem cells by selective inhibition of translation that persists in CSC maintenance, proliferation and metastasis. Oncotarget. 2014 Aug 15; 5(15):6028-37. PMID: 25115391.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  69. Linser R, Bardiaux B, Andreas LB, Hyberts SG, Morris VK, Pintacuda G, Sunde M, Kwan AH, Wagner G. Solid-state NMR structure determination from diagonal-compensated, sparsely nonuniform-sampled 4D proton-proton restraints. J Am Chem Soc. 2014 Aug 06; 136(31):11002-10. PMID: 24988008.
    Citations: 11     Fields:    Translation:Cells
  70. Papadopoulos E, Jenni S, Kabha E, Takrouri KJ, Yi T, Salvi N, Luna RE, Gavathiotis E, Mahalingam P, Arthanari H, Rodriguez-Mias R, Yefidoff-Freedman R, Aktas BH, Chorev M, Halperin JA, Wagner G. Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3187-95. PMID: 25049413.
    Citations: 16     Fields:    Translation:HumansCells
  71. Coote P, Leigh KE, Yu TY, Khaneja N, Wagner G, Arthanari H. A new broadband homonuclear mixing pulse for NMR with low applied power. J Chem Phys. 2014 Jul 14; 141(2):024201. PMID: 25028012.
    Citations: 1     Fields:    
  72. Linser R, Gelev V, Hagn F, Arthanari H, Hyberts SG, Wagner G. Selective methyl labeling of eukaryotic membrane proteins using cell-free expression. J Am Chem Soc. 2014 Aug 13; 136(32):11308-10. PMID: 24937763.
    Citations: 6     Fields:    Translation:HumansCells
  73. Gal M, Li S, Luna RE, Takeuchi K, Wagner G. The LxVP and PxIxIT NFAT motifs bind jointly to overlapping epitopes on calcineurin's catalytic domain distant to the regulatory domain. Structure. 2014 Jul 08; 22(7):1016-27. PMID: 24954618.
    Citations: 4     Fields:    Translation:HumansCells
  74. Edmonds KA, Wagner G. (1)H, (13)C, and (15)N backbone and sidechain chemical shift assignments for the HEAT2 domain of human eIF4GI. Biomol NMR Assign. 2015 Apr; 9(1):157-60. PMID: 24929364.
    Citations:    Fields:    Translation:HumansCells
  75. Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, Wagner G, Aktas BH, Halperin JA, Chorev M. Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction. J Med Chem. 2014 Jun 26; 57(12):5094-111. PMID: 24827861.
    Citations: 5     Fields:    Translation:HumansCells
  76. Elter S, Raschle T, Arens S, Viegas A, Gelev V, Etzkorn M, Wagner G. The use of amphipols for NMR structural characterization of 7-TM proteins. J Membr Biol. 2014 Oct; 247(9-10):957-64. PMID: 24858950.
    Citations: 6     Fields:    Translation:Cells
  77. Brazin KN, Mallis RJ, Li C, Keskin DB, Arthanari H, Gao Y, Wu SL, Karger BL, Wagner G, Reinherz EL. Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments. J Biol Chem. 2014 Jul 04; 289(27):18880-92. PMID: 24849600.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  78. Avnir Y, Tallarico AS, Zhu Q, Bennett AS, Connelly G, Sheehan J, Sui J, Fahmy A, Huang CY, Cadwell G, Bankston LA, McGuire AT, Stamatatos L, Wagner G, Liddington RC, Marasco WA. Molecular signatures of hemagglutinin stem-directed heterosubtypic human neutralizing antibodies against influenza A viruses. PLoS Pathog. 2014 May; 10(5):e1004103. PMID: 24788925.
    Citations: 26     Fields:    Translation:HumansCells
  79. Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G. Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells. Proc Natl Acad Sci U S A. 2014 May 27; 111(21):E2182-90. PMID: 24782546.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  80. Hyberts SG, Arthanari H, Robson SA, Wagner G. Perspectives in magnetic resonance: NMR in the post-FFT era. J Magn Reson. 2014 Apr; 241:60-73. PMID: 24656081.
    Citations: 26     Fields:    Translation:HumansAnimals
  81. Takrouri K, Chen T, Papadopoulos E, Sahoo R, Kabha E, Chen H, Cantel S, Wagner G, Halperin JA, Aktas BH, Chorev M. Structure-activity relationship study of 4EGI-1, small molecule eIF4E/eIF4G protein-protein interaction inhibitors. Eur J Med Chem. 2014 Apr 22; 77:361-77. PMID: 24675136.
    Citations: 3     Fields:    Translation:HumansCells
  82. Yefidoff-Freedman R, Chen T, Sahoo R, Chen L, Wagner G, Halperin JA, Aktas BH, Chorev M. 3-substituted indazoles as configurationally locked 4EGI-1 mimetics and inhibitors of the eIF4E/eIF4G interaction. Chembiochem. 2014 Mar 03; 15(4):595-611. PMID: 24458973.
    Citations: 2     Fields:    Translation:HumansCells
  83. Luna RE, Akabayov SR, Ziarek JJ, Wagner G. Examining weak protein-protein interactions in start codon recognition via NMR spectroscopy. FEBS J. 2014 Apr; 281(8):1965-73. PMID: 24393460.
    Citations: 3     Fields:    Translation:Cells
  84. Luna RE, Arthanari H, Hiraishi H, Akabayov B, Tang L, Cox C, Markus MA, Luna LE, Ikeda Y, Watanabe R, Bedoya E, Yu C, Alikhan S, Wagner G, Asano K. The interaction between eukaryotic initiation factor 1A and eIF5 retains eIF1 within scanning preinitiation complexes. Biochemistry. 2013 Dec 31; 52(52):9510-8. PMID: 24319994.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  85. Martin-Marcos P, Nanda JS, Luna RE, Zhang F, Saini AK, Cherkasova VA, Wagner G, Lorsch JR, Hinnebusch AG. Enhanced eIF1 binding to the 40S ribosome impedes conformational rearrangements of the preinitiation complex and elevates initiation accuracy. RNA. 2014 Feb; 20(2):150-67. PMID: 24335188.
    Citations: 12     Fields:    Translation:AnimalsCells
  86. Sun ZY, Cheng Y, Kim M, Song L, Choi J, Kudahl UJ, Brusic V, Chowdhury B, Yu L, Seaman MS, Bellot G, Shih WM, Wagner G, Reinherz EL. Disruption of helix-capping residues 671 and 674 reveals a role in HIV-1 entry for a specialized hinge segment of the membrane proximal external region of gp41. J Mol Biol. 2014 Mar 06; 426(5):1095-108. PMID: 24075869.
    Citations: 9     Fields:    Translation:HumansCells
  87. Wagner G, Chiu W. Exploring new limits in complex biological structures. Curr Opin Struct Biol. 2013 Oct; 23(5):704-6. PMID: 24076042.
    Citations: 1     Fields:    
  88. Kim M, Song L, Moon J, Sun ZY, Bershteyn A, Hanson M, Cain D, Goka S, Kelsoe G, Wagner G, Irvine D, Reinherz EL. Immunogenicity of membrane-bound HIV-1 gp41 membrane-proximal external region (MPER) segments is dominated by residue accessibility and modulated by stereochemistry. J Biol Chem. 2013 Nov 01; 288(44):31888-901. PMID: 24047898.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  89. Martin-Marcos P, Nanda J, Luna RE, Wagner G, Lorsch JR, Hinnebusch AG. ß-Hairpin loop of eukaryotic initiation factor 1 (eIF1) mediates 40 S ribosome binding to regulate initiator tRNA(Met) recruitment and accuracy of AUG selection in vivo. J Biol Chem. 2013 Sep 20; 288(38):27546-62. PMID: 23893413.
    Citations: 16     Fields:    Translation:AnimalsCells
  90. Akabayov SR, Akabayov B, Richardson CC, Wagner G. Molecular crowding enhanced ATPase activity of the RNA helicase eIF4A correlates with compaction of its quaternary structure and association with eIF4G. J Am Chem Soc. 2013 Jul 10; 135(27):10040-7. PMID: 23767688.
    Citations: 5     Fields:    Translation:HumansCells
  91. Boeszoermenyi A, Schmidt JC, Cheeseman IM, Oberer M, Wagner G, Arthanari H. Resonance assignments of the microtubule-binding domain of the C. elegans spindle and kinetochore-associated protein 1. Biomol NMR Assign. 2014 Oct; 8(2):275-8. PMID: 23765286.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  92. Yi T, Papadopoulos E, Hagner PR, Wagner G. Hypoxia-inducible factor-1a (HIF-1a) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions. J Biol Chem. 2013 Jun 28; 288(26):18732-42. PMID: 23667251.
    Citations: 16     Fields:    Translation:HumansCells
  93. Coote P, Arthanari H, Yu TY, Natarajan A, Wagner G, Khaneja N. Pulse design for broadband correlation NMR spectroscopy by multi-rotating frames. J Biomol NMR. 2013 Mar; 55(3):291-302. PMID: 23420125.
    Citations: 4     Fields:    Translation:Humans
  94. Etzkorn M, Raschle T, Hagn F, Gelev V, Rice AJ, Walz T, Wagner G. Cell-free expressed bacteriorhodopsin in different soluble membrane mimetics: biophysical properties and NMR accessibility. Structure. 2013 Mar 05; 21(3):394-401. PMID: 23415558.
    Citations: 40     Fields:    Translation:Cells
  95. Hagn F, Etzkorn M, Raschle T, Wagner G. Optimized phospholipid bilayer nanodiscs facilitate high-resolution structure determination of membrane proteins. J Am Chem Soc. 2013 Feb 06; 135(5):1919-25. PMID: 23294159.
    Citations: 99     Fields:    Translation:Cells
  96. Akabayov SR, Wagner G. Backbone resonance assignment of the HEAT1-domain of the human eukaryotic translation initiation factor 4GI. Biomol NMR Assign. 2014 Apr; 8(1):89-91. PMID: 23325513.
    Citations: 3     Fields:    Translation:HumansCells
  97. Akabayov B, Akabayov SR, Lee SJ, Wagner G, Richardson CC. Impact of macromolecular crowding on DNA replication. Nat Commun. 2013; 4:1615. PMID: 23511479.
    Citations: 14     Fields:    Translation:Cells
  98. Hyberts SG, Robson SA, Wagner G. Exploring signal-to-noise ratio and sensitivity in non-uniformly sampled multi-dimensional NMR spectra. J Biomol NMR. 2013 Feb; 55(2):167-78. PMID: 23274692.
    Citations: 32     Fields:    
  99. Wommack AJ, Robson SA, Wanniarachchi YA, Wan A, Turner CJ, Wagner G, Nolan EM. NMR solution structure and condition-dependent oligomerization of the antimicrobial peptide human defensin 5. Biochemistry. 2012 Dec 04; 51(48):9624-37. PMID: 23163963.
    Citations: 15     Fields:    Translation:HumansCells
  100. Schmidt JC, Arthanari H, Boeszoermenyi A, Dashkevich NM, Wilson-Kubalek EM, Monnier N, Markus M, Oberer M, Milligan RA, Bathe M, Wagner G, Grishchuk EL, Cheeseman IM. The kinetochore-bound Ska1 complex tracks depolymerizing microtubules and binds to curved protofilaments. Dev Cell. 2012 Nov 13; 23(5):968-80. PMID: 23085020.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  101. Chen L, Aktas BH, Wang Y, He X, Sahoo R, Zhang N, Denoyelle S, Kabha E, Yang H, Freedman RY, Supko JG, Chorev M, Wagner G, Halperin JA. Tumor suppression by small molecule inhibitors of translation initiation. Oncotarget. 2012 Aug; 3(8):869-81. PMID: 22935625.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  102. Luna RE, Arthanari H, Hiraishi H, Nanda J, Martin-Marcos P, Markus MA, Akabayov B, Milbradt AG, Luna LE, Seo HC, Hyberts SG, Fahmy A, Reibarkh M, Miles D, Hagner PR, O'Day EM, Yi T, Marintchev A, Hinnebusch AG, Lorsch JR, Asano K, Wagner G. The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2ß. Cell Rep. 2012 Jun 28; 1(6):689-702. PMID: 22813744.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  103. Kim ST, Shin Y, Brazin K, Mallis RJ, Sun ZY, Wagner G, Lang MJ, Reinherz EL. TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling. Front Immunol. 2012; 3:76. PMID: 22566957.
    Citations: 26     
  104. Eddy MT, Ong TC, Clark L, Teijido O, van der Wel PC, Garces R, Wagner G, Rostovtseva TK, Griffin RG. Lipid dynamics and protein-lipid interactions in 2D crystals formed with the ß-barrel integral membrane protein VDAC1. J Am Chem Soc. 2012 Apr 11; 134(14):6375-87. PMID: 22435461.
    Citations: 23     Fields:    Translation:HumansCells
  105. Hyberts SG, Milbradt AG, Wagner AB, Arthanari H, Wagner G. Application of iterative soft thresholding for fast reconstruction of NMR data non-uniformly sampled with multidimensional Poisson Gap scheduling. J Biomol NMR. 2012 Apr; 52(4):315-27. PMID: 22331404.
    Citations: 84     Fields:    
  106. Hyberts SG, Arthanari H, Wagner G. Applications of non-uniform sampling and processing. Top Curr Chem. 2012; 316:125-48. PMID: 21796515.
    Citations: 36     Fields:    
  107. Yu TY, Raschle T, Hiller S, Wagner G. Solution NMR spectroscopic characterization of human VDAC-2 in detergent micelles and lipid bilayer nanodiscs. Biochim Biophys Acta. 2012 Jun; 1818(6):1562-9. PMID: 22119777.
    Citations: 16     Fields:    Translation:HumansCells
  108. Gal M, Edmonds KA, Milbradt AG, Takeuchi K, Wagner G. Speeding up direct (15)N detection: hCaN 2D NMR experiment. J Biomol NMR. 2011 Dec; 51(4):497-504. PMID: 22038648.
    Citations: 7     Fields:    Translation:HumansCells
  109. Kim M, Sun ZY, Rand KD, Shi X, Song L, Cheng Y, Fahmy AF, Majumdar S, Ofek G, Yang Y, Kwong PD, Wang JH, Engen JR, Wagner G, Reinherz EL. Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization. Nat Struct Mol Biol. 2011 Oct 16; 18(11):1235-43. PMID: 22002224.
    Citations: 42     Fields:    Translation:HumansCells
  110. Shaw BF, Schneider GF, Arthanari H, Narovlyansky M, Moustakas D, Durazo A, Wagner G, Whitesides GM. Complexes of native ubiquitin and dodecyl sulfate illustrate the nature of hydrophobic and electrostatic interactions in the binding of proteins and surfactants. J Am Chem Soc. 2011 Nov 09; 133(44):17681-95. PMID: 21939262.
    Citations: 9     Fields:    Translation:Cells
  111. Narayanan S, Arthanari H, Wolfe MS, Wagner G. Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly. J Biol Chem. 2011 Dec 23; 286(51):44266-76. PMID: 21998303.
    Citations: 15     Fields:    Translation:HumansCells
  112. Fahmy A, Wagner G. Optimization of van der Waals energy for protein side-chain placement and design. Biophys J. 2011 Oct 05; 101(7):1690-8. PMID: 21961595.
    Citations: 2     Fields:    Translation:Cells
  113. Yi CH, Pan H, Seebacher J, Jang IH, Hyberts SG, Heffron GJ, Vander Heiden MG, Yang R, Li F, Locasale JW, Sharfi H, Zhai B, Rodriguez-Mias R, Luithardt H, Cantley LC, Daley GQ, Asara JM, Gygi SP, Wagner G, Liu CF, Yuan J. Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell. 2011 Aug 19; 146(4):607-20. PMID: 21854985.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  114. Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC, Vander Heiden MG. Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet. 2011 Jul 31; 43(9):869-74. PMID: 21804546.
    Citations: 293     Fields:    Translation:HumansCells
  115. Zinoviev A, Léger M, Wagner G, Shapira M. A novel 4E-interacting protein in Leishmania is involved in stage-specific translation pathways. Nucleic Acids Res. 2011 Oct; 39(19):8404-15. PMID: 21764780.
    Citations: 22     Fields:    Translation:AnimalsCells
  116. Milbradt AG, Kulkarni M, Yi T, Takeuchi K, Sun ZY, Luna RE, Selenko P, Näär AM, Wagner G. Structure of the VP16 transactivator target in the Mediator. Nat Struct Mol Biol. 2011 Apr; 18(4):410-5. PMID: 21378963.