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Kevin Joseph Staley, M.D.

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Mentoring
Available: 10/01/18, Expires: 12/31/19

GABA is the principal inhibitory neurotransmitter in the mature brain, but GABA can excite neurons in the injured brain. Most seizure medications enhance the effects of GABA, and thus work poorly for seizures in the setting of brain injury, particularly in the neonate period. We have developed therapies that can alter the polarity GABA signaling, but how well these agents cross the blood brain barrier is still not well defined. Students will participate in therapeutic experiments involving multiphoton in vivo microscopy in transgenic animals expressing fluorophores that read out the polarity of GABA signaling.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS096948 (STALEY, KEVIN J.) Jun 1, 2017 - May 31, 2019
    NIH/NINDS
    Anticonvulsant screening using chronic epilepsy models
    Role: Principal Investigator
  2. U01MH106013 (STALEY, KEVIN J.) Sep 26, 2014 - Jun 30, 2017
    NIH/NIMH
    Mapping neuronal chloride microdomains
    Role: Principal Investigator
  3. R01NS086364 (STALEY, KEVIN J.) Sep 1, 2013 - May 31, 2018
    NIH/NINDS
    Biomarkers for epileptogenesis after brain injury
    Role: Co-Principal Investigator
  4. K12NS066225 (STALEY, KEVIN J.) Sep 1, 2011 - Aug 31, 2016
    NIH/NINDS
    Pediatric Neurology Physician Scientist Program.
    Role: Principal Investigator
  5. R37NS077908 (STALEY, KEVIN J.) Aug 1, 2011 - Jul 31, 2019
    NIH/NINDS
    Mechanisms of neuronal death during epileptogenesis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kramer MA, Ostrowski LM, Song DY, Thorn EL, Stoyell SM, Parnes M, Chinappen D, Xiao G, Eden UT, Staley KJ, Stufflebeam SM, Chu CJ. Scalp recorded spike ripples predict seizure risk in childhood epilepsy better than spikes. Brain. 2019 May 01; 142(5):1296-1309. PMID: 30907404.
    Citations:    
  2. Glykys J, Duquette E, Rahmati N, Duquette K, Staley KJ. Mannitol decreases neocortical epileptiform activity during early brain development via cotransport of chloride and water. Neurobiol Dis. 2019 05; 125:163-175. PMID: 30711483.
    Citations:    
  3. Jacob T, Lillis KP, Wang Z, Swiercz W, Rahmati N, Staley KJ. A Proposed Mechanism for Spontaneous Transitions between Interictal and Ictal Activity. J Neurosci. 2019 Jan 16; 39(3):557-575. PMID: 30446533.
    Citations:    Fields:    
  4. Costine-Bartell BA, McGuone D, Price G, Crawford E, Keeley KL, Munoz-Pareja J, Dodge CP, Staley K, Duhaime AC. Development of a Model of Hemispheric Hypodensity ("Big Black Brain"). J Neurotrauma. 2019 Mar 01; 36(5):815-833. PMID: 30039743.
    Citations:    Fields:    
  5. Blauwblomme T, Dzhala V, Staley K. Transient ischemia facilitates neuronal chloride accumulation and severity of seizures. Ann Clin Transl Neurol. 2018 Sep; 5(9):1048-1061. PMID: 30250862.
    Citations:    
  6. Kim JA, Boyle EJ, Wu AC, Cole AJ, Staley KJ, Zafar S, Cash SS, Westover MB. Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy. Ann Neurol. 2018 Apr; 83(4):858-862. PMID: 29537656.
    Citations: 1     Fields:    
  7. Lillis KP, Staley KJ. Optogenetic dissection of ictogenesis: in search of a targeted anti-epileptic therapy. J Neural Eng. 2018 Aug; 15(4):041001. PMID: 29536948.
    Citations:    Fields:    
  8. Moyer JT, Gnatkovsky V, Ono T, Otáhal J, Wagenaar J, Stacey WC, Noebels J, Ikeda A, Staley K, de Curtis M, Litt B, Galanopoulou AS. Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 11; 58 Suppl 4:53-67. PMID: 29105070.
    Citations: 4     Fields:    Translation:Animals
  9. Glykys J, Dzhala V, Egawa K, Kahle KT, Delpire E, Staley K. Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential. Trends Neurosci. 2017 05; 40(5):276-294. PMID: 28431741.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  10. Liu J, Saponjian Y, Mahoney MM, Staley KJ, Berdichevsky Y. Epileptogenesis in organotypic hippocampal cultures has limited dependence on culture medium composition. PLoS One. 2017; 12(2):e0172677. PMID: 28225808.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Chu CJ, Chan A, Song D, Staley KJ, Stufflebeam SM, Kramer MA. A semi-automated method for rapid detection of ripple events on interictal voltage discharges in the scalp electroencephalogram. J Neurosci Methods. 2017 02 01; 277:46-55. PMID: 27988323.
    Citations: 1     Fields:    Translation:HumansAnimals
  12. Berdichevsky Y, Saponjian Y, Park KI, Roach B, Pouliot W, Lu K, Swiercz W, Dudek FE, Staley KJ. Staged anticonvulsant screening for chronic epilepsy. Ann Clin Transl Neurol. 2016 12; 3(12):908-923. PMID: 28097203.
    Citations: 1     
  13. Song Y, Pimentel C, Walters K, Boller L, Ghiasvand S, Liu J, Staley KJ, Berdichevsky Y. Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury. Sci Rep. 2016 08 26; 6:32095. PMID: 27561791.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. Glykys J, Staley KJ. Developmental Decrease of Neuronal Chloride Concentration Is Independent of Trauma in Thalamocortical Brain Slices. PLoS One. 2016; 11(6):e0158012. PMID: 27337272.
    Citations: 1     Fields:    Translation:AnimalsCells
  15. Kahle KT, Khanna AR, Duan J, Staley KJ, Delpire E, Poduri A. The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition. Neuroscientist. 2016 12; 22(6):555-562. PMID: 27130838.
    Citations: 9     Fields:    Translation:HumansAnimals
  16. Glykys J, Staley KJ. Diazepam effect during early neonatal development correlates with neuronal Cl(.). Ann Clin Transl Neurol. 2015 12; 2(12):1055-70. PMID: 26734658.
    Citations: 2     
  17. Pitkänen A, Lukasiuk K, Dudek FE, Staley KJ. Epileptogenesis. Cold Spring Harb Perspect Med. 2015 Sep 18; 5(10). PMID: 26385090.
    Citations: 14     Fields:    Translation:HumansAnimals
  18. Lillis KP, Wang Z, Mail M, Zhao GQ, Berdichevsky Y, Bacskai B, Staley KJ. Evolution of Network Synchronization during Early Epileptogenesis Parallels Synaptic Circuit Alterations. J Neurosci. 2015 Jul 08; 35(27):9920-34. PMID: 26156993.
    Citations: 16     Fields:    Translation:AnimalsCells
  19. Trevelyan AJ, Muldoon SF, Merricks EM, Racca C, Staley KJ. The role of inhibition in epileptic networks. J Clin Neurophysiol. 2015 Jun; 32(3):227-34. PMID: 26035675.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-Rachamimov A, Staley KJ. Failure to detect human papillomavirus in focal cortical dysplasia type IIb. Ann Neurol. 2015 Jul; 78(1):63-7. PMID: 25893423.
    Citations:    Fields:    Translation:HumansCells
  21. Park KI, Dzhala V, Saponjian Y, Staley KJ. What Elements of the Inflammatory System Are Necessary for Epileptogenesis In Vitro? eNeuro. 2015 Mar-Apr; 2(2). PMID: 26464976.
    Citations: 2     Fields:    
  22. Staley K. Molecular mechanisms of epilepsy. Nat Neurosci. 2015 Mar; 18(3):367-72. PMID: 25710839.
    Citations: 20     Fields:    Translation:HumansAnimals
  23. Dzhala V, Staley KJ. Acute and chronic efficacy of bumetanide in an in vitro model of posttraumatic epileptogenesis. CNS Neurosci Ther. 2015 Feb; 21(2):173-80. PMID: 25495911.
    Citations: 7     Fields:    Translation:Animals
  24. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science. 2014 Sep 05; 345(6201):1130. PMID: 25190789.
    Citations: 4     Fields:    Translation:AnimalsCells
  25. Delpire E, Staley KJ. Novel determinants of the neuronal Cl(-) concentration. J Physiol. 2014 Oct 01; 592(19):4099-114. PMID: 25107928.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Local impermeant anions establish the neuronal chloride concentration. Science. 2014 Feb 07; 343(6171):670-5. PMID: 24503855.
    Citations: 52     Fields:    Translation:AnimalsCells
  27. Heinemann U, Staley KJ. What is the clinical relevance of in vitro epileptiform activity? Adv Exp Med Biol. 2014; 813:25-41. PMID: 25012364.
    Citations: 3     Fields:    Translation:Humans
  28. Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathol. 2014 Feb; 127(2):257-70. PMID: 24271788.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  29. Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Dudek FE. Epilepsy therapy development: technical and methodologic issues in studies with animal models. Epilepsia. 2013 Aug; 54 Suppl 4:13-23. PMID: 23909850.
    Citations: 11     Fields:    Translation:HumansAnimals
  30. O'Brien TJ, Ben-Menachem E, Bertram EH, Collins SD, Kokaia M, Lerche H, Klitgaard H, Staley KJ, Vaudano E, Walker MC, Simonato M. Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development. Epilepsia. 2013 Aug; 54 Suppl 4:70-4. PMID: 23909855.
    Citations: 4     Fields:    Translation:HumansAnimals
  31. Berdichevsky Y, Dryer AM, Saponjian Y, Mahoney MM, Pimentel CA, Lucini CA, Usenovic M, Staley KJ. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy. J Neurosci. 2013 May 22; 33(21):9056-67. PMID: 23699517.
    Citations: 27     Fields:    Translation:AnimalsCells
  32. Diao L, Hellier JL, Uskert-Newsom J, Williams PA, Staley KJ, Yee AS. Diphenytoin, riluzole and lidocaine: three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity. Neuropharmacology. 2013 Oct; 73:48-55. PMID: 23707481.
    Citations: 3     Fields:    Translation:Animals
  33. Dobelis P, Staley KJ, Cooper DC. Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. PLoS One. 2012; 7(7):e41108. PMID: 22848433.
    Citations: 12     Fields:    Translation:AnimalsCells
  34. Staley K. Neonatal encephalopathy, MRI lesions, and later epilepsy: no harm, no foul? Epilepsy Curr. 2012 Jul; 12(4):128-30. PMID: 22936880.
    Citations:    
  35. Simonato M, Löscher W, Cole AJ, Dudek FE, Engel J, Kaminski RM, Loeb JA, Scharfman H, Staley KJ, Velíšek L, Klitgaard H. Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design. Epilepsia. 2012 Nov; 53(11):1860-7. PMID: 22708847.
    Citations: 19     Fields:    Translation:HumansAnimals
  36. Lillis KP, Kramer MA, Mertz J, Staley KJ, White JA. Pyramidal cells accumulate chloride at seizure onset. Neurobiol Dis. 2012 Sep; 47(3):358-66. PMID: 22677032.
    Citations: 27     Fields:    Translation:AnimalsCells
  37. Dzhala V, Valeeva G, Glykys J, Khazipov R, Staley K. Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain. J Neurosci. 2012 Mar 21; 32(12):4017-31. PMID: 22442068.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  38. Sabolek HR, Swiercz WB, Lillis KP, Cash SS, Huberfeld G, Zhao G, Ste Marie L, Clemenceau S, Barsh G, Miles R, Staley KJ. A candidate mechanism underlying the variance of interictal spike propagation. J Neurosci. 2012 Feb 29; 32(9):3009-21. PMID: 22378874.
    Citations: 19     Fields:    Translation:HumansAnimals
  39. Seker E, Berdichevsky Y, Staley KJ, Yarmush ML. Microfabrication-compatible nanoporous gold foams as biomaterials for drug delivery. Adv Healthc Mater. 2012 Mar; 1(2):172-6. PMID: 23184720.
    Citations: 4     Fields:    Translation:AnimalsCells
  40. Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia. 2012 Mar; 53(3):571-82. PMID: 22292566.
    Citations: 46     Fields:    Translation:HumansAnimals
  41. Dudek FE, Staley KJ. Seizure probability in animal models of acquired epilepsy: a perspective on the concept of the preictal state. Epilepsy Res. 2011 Dec; 97(3):324-31. PMID: 22094446.
    Citations: 7     Fields:    Translation:HumansAnimals
  42. Berdichevsky Y, Dzhala V, Mail M, Staley KJ. Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. Neurobiol Dis. 2012 Feb; 45(2):774-85. PMID: 22115940.
    Citations: 20     Fields:    Translation:Animals
  43. Staley K. Carts, Horses, and Push-Pull Regulation of EGABA in Neonatal Seizures. Epilepsy Curr. 2011 Nov; 11(6):205-8. PMID: 22129766.
    Citations: 1     
  44. Maa EH, Kahle KT, Walcott BP, Spitz MC, Staley KJ. Diuretics and epilepsy: will the past and present meet? Epilepsia. 2011 Sep; 52(9):1559-69. PMID: 21838793.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  45. Vandeventer S, Studnek JR, Garrett JS, Ward SR, Staley K, Blackwell T. The association between ambulance hospital turnaround times and patient acuity, destination hospital, and time of day. Prehosp Emerg Care. 2011 Jul-Sep; 15(3):366-70. PMID: 21480775.
    Citations: 1     Fields:    Translation:Humans
  46. Köhling R, Staley K. Network mechanisms for fast ripple activity in epileptic tissue. Epilepsy Res. 2011 Dec; 97(3):318-23. PMID: 21470826.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  47. Dudek FE, Staley KJ. The time course of acquired epilepsy: implications for therapeutic intervention to suppress epileptogenesis. Neurosci Lett. 2011 Jun 27; 497(3):240-6. PMID: 21458536.
    Citations: 20     Fields:    Translation:HumansAnimals
  48. Staley KJ, White A, Dudek FE. Interictal spikes: harbingers or causes of epilepsy? Neurosci Lett. 2011 Jun 27; 497(3):247-50. PMID: 21458535.
    Citations: 33     Fields:    Translation:HumansAnimals
  49. Kahle KT, Walcott BP, Staley KJ. Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport. J Child Neurol. 2011 Feb; 26(2):205-8. PMID: 21285039.
    Citations: 2     Fields:    Translation:Humans
  50. Dyhrfjeld-Johnsen J, Berdichevsky Y, Swiercz W, Sabolek H, Staley KJ. Interictal spikes precede ictal discharges in an organotypic hippocampal slice culture model of epileptogenesis. J Clin Neurophysiol. 2010 Dec; 27(6):418-24. PMID: 21076333.
    Citations: 38     Fields:    Translation:Animals
  51. Staley K. Stroke: recovery inhibitors under attack. Nature. 2010 Nov 11; 468(7321):176-7. PMID: 21068818.
    Citations: 1     Fields:    Translation:AnimalsCells
  52. Shin JH, Smith D, Swiercz W, Staley K, Rickard JT, Montero J, Kurgan LA, Cios KJ. Recognition of partially occluded and rotated images with a network of spiking neurons. IEEE Trans Neural Netw. 2010 Nov; 21(11):1697-709. PMID: 21047704.
    Citations: 2     Fields:    Translation:HumansCells
  53. Dzhala VI, Kuchibhotla KV, Glykys JC, Kahle KT, Swiercz WB, Feng G, Kuner T, Augustine GJ, Bacskai BJ, Staley KJ. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci. 2010 Sep 01; 30(35):11745-61. PMID: 20810895.
    Citations: 52     Fields:    Translation:AnimalsCells
  54. Dredge DC, Parsons EC, Carter LP, Staley KJ. Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin. Pediatr Neurol. 2010 Jul; 43(1):65-9. PMID: 20682208.
    Citations: 1     Fields:    Translation:Humans
  55. Dudek FE, Pouliot WA, Rossi CA, Staley KJ. The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat. Epilepsia. 2010 Jul; 51 Suppl 3:126-30. PMID: 20618417.
    Citations: 9     Fields:    Translation:Animals
  56. Dudek FE, Ekstrand JJ, Staley KJ. Is neuronal death necessary for acquired epileptogenesis in the immature brain? Epilepsy Curr. 2010 Jul; 10(4):95-9. PMID: 20697505.
    Citations: 10     
  57. Seker E, Berdichevsky Y, Begley MR, Reed ML, Staley KJ, Yarmush ML. The fabrication of low-impedance nanoporous gold multiple-electrode arrays for neural electrophysiology studies. Nanotechnology. 2010 Mar 26; 21(12):125504. PMID: 20203356.
    Citations: 15     Fields:    Translation:AnimalsCells
  58. Berdichevsky Y, Staley KJ, Yarmush ML. Building and manipulating neural pathways with microfluidics. Lab Chip. 2010 Apr 21; 10(8):999-1004. PMID: 20358106.
    Citations: 19     Fields:    Translation:AnimalsCells
  59. Kadam SD, White AM, Staley KJ, Dudek FE. Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy. J Neurosci. 2010 Jan 06; 30(1):404-15. PMID: 20053921.
    Citations: 44     Fields:    Translation:Animals
  60. White A, Williams PA, Hellier JL, Clark S, Dudek FE, Staley KJ. EEG spike activity precedes epilepsy after kainate-induced status epilepticus. Epilepsia. 2010 Mar; 51(3):371-83. PMID: 19845739.
    Citations: 45     Fields:    Translation:HumansAnimals
  61. Glykys J, Dzhala VI, Kuchibhotla KV, Feng G, Kuner T, Augustine G, Bacskai BJ, Staley KJ. Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron. 2009 Sep 10; 63(5):657-72. PMID: 19755108.
    Citations: 49     Fields:    Translation:AnimalsCells
  62. Kahle KT, Simard JM, Staley KJ, Nahed BV, Jones PS, Sun D. Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport. Physiology (Bethesda). 2009 Aug; 24:257-65. PMID: 19675357.
    Citations: 60     Fields:    Translation:HumansAnimals
  63. Dulla CG, Frenguelli BG, Staley KJ, Masino SA. Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus. J Neurophysiol. 2009 Sep; 102(3):1984-93. PMID: 19625534.
    Citations: 16     Fields:    Translation:AnimalsCells
  64. Kahle KT, Barnett SM, Sassower KC, Staley KJ. Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1. J Child Neurol. 2009 May; 24(5):572-6. PMID: 19406757.
    Citations: 30     Fields:    Translation:Humans
  65. Williams PA, White AM, Clark S, Ferraro DJ, Swiercz W, Staley KJ, Dudek FE. Development of spontaneous recurrent seizures after kainate-induced status epilepticus. J Neurosci. 2009 Feb 18; 29(7):2103-12. PMID: 19228963.
    Citations: 122     Fields:    Translation:AnimalsCells
  66. Staley KJ, Anderson AE. Hyperactive interneurons impair learning in a neurofibromatosis model. Nat Neurosci. 2009 Jan; 12(1):8-10. PMID: 19107143.
    Citations: 1     Fields:    Translation:AnimalsCells
  67. Berdichevsky Y, Sabolek H, Levine JB, Staley KJ, Yarmush ML. Microfluidics and multielectrode array-compatible organotypic slice culture method. J Neurosci Methods. 2009 Mar 30; 178(1):59-64. PMID: 19100768.
    Citations: 18     Fields:    Translation:AnimalsCells
  68. Frey LC, Hellier J, Unkart C, Lepkin A, Howard A, Hasebroock K, Serkova N, Liang L, Patel M, Soltesz I, Staley K. A novel apparatus for lateral fluid percussion injury in the rat. J Neurosci Methods. 2009 Mar 15; 177(2):267-72. PMID: 19022291.
    Citations: 10     Fields:    Translation:Animals
  69. Hellier JL, White A, Williams PA, Dudek FE, Staley KJ. NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy. Neuropharmacology. 2009 Feb; 56(2):414-21. PMID: 18930747.
    Citations: 9     Fields:    Translation:Animals
  70. Staley KJ, Sims KB, Grant PE, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 28-2008. An 8-day-old infant with congenital deafness, lethargy, and hypothermia. N Engl J Med. 2008 Sep 11; 359(11):1156-67. PMID: 18784106.
    Citations:    Fields:    Translation:Humans
  71. Kahle KT, Staley KJ. The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Neurosurg Focus. 2008 Sep; 25(3):E22. PMID: 18759624.
    Citations: 24     Fields:    Translation:HumansAnimals
  72. Kahle KT, Staley KJ, Nahed BV, Gamba G, Hebert SC, Lifton RP, Mount DB. Roles of the cation-chloride cotransporters in neurological disease. Nat Clin Pract Neurol. 2008 Sep; 4(9):490-503. PMID: 18769373.
    Citations: 119     Fields:    Translation:HumansAnimals
  73. Staley KJ. Does plasticity of the GABA(A) reversal potential contribute to epileptogenesis? Epilepsy Curr. 2008 Jul-Aug; 8(4):107-10. PMID: 18596880.
    Citations: 2     
  74. Kahle KT, Staley K. Altered neuronal chloride homeostasis and excitatory GABAergic signaling in human temporal lobe epilepsy. Epilepsy Curr. 2008 Mar-Apr; 8(2):51-3. PMID: 18330470.
    Citations: 7     
  75. Brumback AC, Staley KJ. Thermodynamic regulation of NKCC1-mediated Cl- cotransport underlies plasticity of GABA(A) signaling in neonatal neurons. J Neurosci. 2008 Feb 06; 28(6):1301-12. PMID: 18256250.
    Citations: 41     Fields:    Translation:AnimalsCells
  76. Dzhala VI, Brumback AC, Staley KJ. Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. Ann Neurol. 2008 Feb; 63(2):222-35. PMID: 17918265.
    Citations: 79     Fields:    Translation:Animals
  77. Jarrett SG, Liang LP, Hellier JL, Staley KJ, Patel M. Mitochondrial DNA damage and impaired base excision repair during epileptogenesis. Neurobiol Dis. 2008 Apr; 30(1):130-8. PMID: 18295498.
    Citations: 30     Fields:    Translation:AnimalsCells
  78. Dudek FE, Bertram EH, Staley KJ. Antiepileptogenesis Therapy with Levetiracetam: Data from Kindling versus Status Epilepticus Models. Epilepsy Curr. 2008 Jan-Feb; 8(1):28-30. PMID: 18265888.
    Citations: 7     
  79. Staley KJ. Neurons skip a beat during fast ripples. Neuron. 2007 Sep 20; 55(6):828-30. PMID: 17880888.
    Citations: 8     Fields:    Translation:AnimalsCells
  80. Hellier JL, Grosshans DR, Coultrap SJ, Jones JP, Dobelis P, Browning MD, Staley KJ. NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network. J Neurophysiol. 2007 Nov; 98(5):2818-26. PMID: 17728388.
    Citations: 9     Fields:    Translation:AnimalsCells
  81. Dudek FE, Staley KJ. How does the balance of excitation and inhibition shift during epileptogenesis? Epilepsy Curr. 2007 May-Jun; 7(3):86-8. PMID: 17520084.
    Citations: 3     
  82. Swiercz W, Cios K, Hellier J, Yee A, Staley K. Effects of synaptic depression and recovery on synchronous network activity. J Clin Neurophysiol. 2007 Apr; 24(2):165-74. PMID: 17414972.
    Citations: 3     Fields:    Translation:AnimalsCells
  83. Jones J, Stubblefield EA, Benke TA, Staley KJ. Desynchronization of glutamate release prolongs synchronous CA3 network activity. J Neurophysiol. 2007 May; 97(5):3812-8. PMID: 17344368.
    Citations: 12     Fields:    Translation:AnimalsCells
  84. Schuyler R, White A, Staley K, Cios KJ. Epileptic seizure detection. IEEE Eng Med Biol Mag. 2007 Mar-Apr; 26(2):74-82. PMID: 17441611.
    Citations: 2     Fields:    Translation:Humans
  85. Williams PA, Hellier JL, White AM, Staley KJ, Dudek FE. Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis. Epilepsia. 2007; 48 Suppl 5:157-63. PMID: 17910596.
    Citations: 24     Fields:    Translation:HumansAnimals
  86. Soltesz I, Staley K. High times for memory: cannabis disrupts temporal coordination among hippocampal neurons. Nat Neurosci. 2006 Dec; 9(12):1461-3. PMID: 17128279.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  87. Staley KJ, Dudek FE. Interictal spikes and epileptogenesis. Epilepsy Curr. 2006 Nov-Dec; 6(6):199-202. PMID: 17260059.
    Citations: 39     
  88. Dudek FE, Staley KJ. Laser scanning photostimulation: new evidence for enhanced recurrent excitation in a model of posttraumatic epilepsy. Epilepsy Curr. 2006 Nov-Dec; 6(6):215-6. PMID: 17260064.
    Citations:    
  89. Staley KJ, Huguenard JR. A thalamic sleep tonic. Epilepsy Curr. 2006 Sep-Oct; 6(5):164-6. PMID: 17260047.
    Citations:    
  90. Staley KJ. Wrong-way chloride transport: is it a treatable cause of some intractable seizures? Epilepsy Curr. 2006 Jul-Aug; 6(4):124-7. PMID: 17260033.
    Citations: 7     
  91. Prescott C, Weeks AM, Staley KJ, Partin KM. Kynurenic acid has a dual action on AMPA receptor responses. Neurosci Lett. 2006 Jul 10; 402(1-2):108-12. PMID: 16644124.
    Citations: 34     Fields:    Translation:AnimalsCells
  92. Williams P, White A, Ferraro D, Clark S, Staley K, Dudek FE. The use of radiotelemetry to evaluate electrographic seizures in rats with kainate-induced epilepsy. J Neurosci Methods. 2006 Jul 15; 155(1):39-48. PMID: 16564574.
    Citations: 16     Fields:    Translation:AnimalsCells
  93. Swiercz W, Cios KJ, Staley K, Kurgan L, Accurso F, Sagel S. A new synaptic plasticity rule for networks of spiking neurons. IEEE Trans Neural Netw. 2006 Jan; 17(1):94-105. PMID: 16526479.
    Citations: 2     Fields:    Translation:HumansCells
  94. Dulla CG, Dobelis P, Pearson T, Frenguelli BG, Staley KJ, Masino SA. Adenosine and ATP link PCO2 to cortical excitability via pH. Neuron. 2005 Dec 22; 48(6):1011-23. PMID: 16364904.
    Citations: 60     Fields:    Translation:AnimalsCells
  95. White AM, Williams PA, Ferraro DJ, Clark S, Kadam SD, Dudek FE, Staley KJ. Efficient unsupervised algorithms for the detection of seizures in continuous EEG recordings from rats after brain injury. J Neurosci Methods. 2006 Apr 15; 152(1-2):255-66. PMID: 16337006.
    Citations: 32     Fields:    Translation:Animals
  96. Dudek FE, Staley KJ. Chronic cortical injury and epileptogensis: a possible role for intracellular chloride homeostasis. Epilepsy Curr. 2005 Nov-Dec; 5(6):239-40. PMID: 16372061.
    Citations:    
  97. Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke TA, Delpire E, Jensen FE, Staley KJ. NKCC1 transporter facilitates seizures in the developing brain. Nat Med. 2005 Nov; 11(11):1205-13. PMID: 16227993.
    Citations: 269     Fields:    Translation:HumansAnimals
  98. Staley K, Hellier JL, Dudek FE. Do interictal spikes drive epileptogenesis? Neuroscientist. 2005 Aug; 11(4):272-6. PMID: 16061513.
    Citations: 37     Fields:    Translation:HumansAnimals
  99. Staley K, Scharfman H. A woman's prerogative. Nat Neurosci. 2005 Jun; 8(6):697-9. PMID: 15917829.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  100. Dzhala VI, Staley KJ. Mechanisms of fast ripples in the hippocampus. J Neurosci. 2004 Oct 06; 24(40):8896-906. PMID: 15470156.
    Citations: 42     Fields:    Translation:AnimalsCells
  101. Staley K. Neuroscience. Epileptic neurons go wireless. Science. 2004 Jul 23; 305(5683):482-3. PMID: 15273382.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  102. Staley KJ. Role of the depolarizing GABA response in epilepsy. Adv Exp Med Biol. 2004; 548:104-9. PMID: 15250589.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  103. Staley K. Salt and wounds: a new mechanism for neuropathic pain. Nat Med. 2003 Sep; 9(9):1110-1. PMID: 12949519.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  104. Dzhala VI, Staley KJ. Transition from interictal to ictal activity in limbic networks in vitro. J Neurosci. 2003 Aug 27; 23(21):7873-80. PMID: 12944517.
    Citations: 42     Fields:    Translation:AnimalsCells
  105. Dzhala VI, Staley KJ. Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus. J Neurosci. 2003 Mar 01; 23(5):1840-6. PMID: 12629188.
    Citations: 46     Fields:    Translation:AnimalsCells
  106. Yee AS, Longacher JM, Staley KJ. Convulsant and anticonvulsant effects on spontaneous CA3 population bursts. J Neurophysiol. 2003 Jan; 89(1):427-41. PMID: 12522191.
    Citations: 6     Fields:    Translation:AnimalsCells
  107. Dudek FE, Staley KJ, Sutula TP. The search for animal models of epileptogenesis and pharmacoresistance: are there biologic barriers to simple validation strategies? Epilepsia. 2002 Nov; 43(11):1275-7. PMID: 12423376.
    Citations: 3     Fields:    Translation:Animals
  108. Staley KJ. Diuretics as Antiepileptic Drugs: Should We Go with the Flow? Epilepsy Curr. 2002 Mar; 2(2):35-38. PMID: 15309160.
    Citations: 5     
  109. Dudek FE, Hellier JL, Williams PA, Ferraro DJ, Staley KJ. The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus. Prog Brain Res. 2002; 135:53-65. PMID: 12143370.
    Citations: 25     Fields:    Translation:AnimalsCells
  110. Staley KJ, Bains JS, Yee A, Hellier J, Longacher JM. Statistical model relating CA3 burst probability to recovery from burst-induced depression at recurrent collateral synapses. J Neurophysiol. 2001 Dec; 86(6):2736-47. PMID: 11731533.
    Citations: 13     Fields:    Translation:AnimalsCells
  111. Staley K, Smith R. A new form of feedback at the GABA(A) receptor. Nat Neurosci. 2001 Jul; 4(7):674-6. PMID: 11426214.
    Citations: 10     Fields:    Translation:AnimalsCells
  112. Smith RL, Traul DL, Schaack J, Clayton GH, Staley KJ, Wilcox CL. Characterization of promoter function and cell-type-specific expression from viral vectors in the nervous system. J Virol. 2000 Dec; 74(23):11254-61. PMID: 11070024.
    Citations: 14     Fields:    Translation:AnimalsCells
  113. Staley KJ, Proctor WR. Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport. J Physiol. 1999 Sep 15; 519 Pt 3:693-712. PMID: 10457084.
    Citations: 74     Fields:    Translation:AnimalsCells
  114. Bains JS, Longacher JM, Staley KJ. Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses. Nat Neurosci. 1999 Aug; 2(8):720-6. PMID: 10412061.
    Citations: 44     Fields:    Translation:AnimalsCells
  115. Staley KJ. Quantal GABA release: noise or not? Nat Neurosci. 1999 Jun; 2(6):494-5. PMID: 10448209.
    Citations: 4     Fields:    Translation:AnimalsCells
  116. Staley KJ, Longacher M, Bains JS, Yee A. Presynaptic modulation of CA3 network activity. Nat Neurosci. 1998 Jul; 1(3):201-9. PMID: 10195144.
    Citations: 42     Fields:    Translation:AnimalsCells
  117. Clayton GH, Staley KJ, Wilcox CL, Owens GC, Smith RL. Developmental expression of C1C-2 in the rat nervous system. Brain Res Dev Brain Res. 1998 Jun 15; 108(1-2):307-18. PMID: 9693808.
    Citations: 3     Fields:    Translation:Animals
  118. Hinks GL, Shah B, French SJ, Campos LS, Staley K, Hughes J, Sofroniew MV. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity. J Neurosci. 1997 Jul 15; 17(14):5549-59. PMID: 9204936.
    Citations: 18     Fields:    Translation:Animals
  119. Staley K, Smith R, Schaack J, Wilcox C, Jentsch TJ. Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel. Neuron. 1996 Sep; 17(3):543-51. PMID: 8816717.
    Citations: 53     Fields:    Translation:AnimalsCells
  120. Staley KJ, Soldo BL, Proctor WR. Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science. 1995 Aug 18; 269(5226):977-81. PMID: 7638623.
    Citations: 155     Fields:    Translation:AnimalsCells
  121. Smith RL, Clayton GH, Wilcox CL, Escudero KW, Staley KJ. Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition. J Neurosci. 1995 May; 15(5 Pt 2):4057-67. PMID: 7751965.
    Citations: 33     Fields:    Translation:AnimalsCells
  122. Staley K. The role of an inwardly rectifying chloride conductance in postsynaptic inhibition. J Neurophysiol. 1994 Jul; 72(1):273-84. PMID: 7965011.
    Citations: 29     Fields:    Translation:AnimalsCells
  123. Mody I, Staley KJ. Cell properties in the epileptic hippocampus. Hippocampus. 1994 Jun; 4(3):275-80. PMID: 7531092.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  124. Svendsen CN, Kew JN, Staley K, Sofroniew MV. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J Neurosci. 1994 Jan; 14(1):75-87. PMID: 8283253.
    Citations: 10     Fields:    Translation:AnimalsCells
  125. Staley K. Enhancement of the excitatory actions of GABA by barbiturates and benzodiazepines. Neurosci Lett. 1992 Oct 26; 146(1):105-7. PMID: 1282225.
    Citations: 10     Fields:    Translation:AnimalsCells
  126. Staley KJ, Mody I. Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance. J Neurophysiol. 1992 Jul; 68(1):197-212. PMID: 1381418.
    Citations: 82     Fields:    Translation:AnimalsCells
  127. Staley KJ, Otis TS, Mody I. Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings. J Neurophysiol. 1992 May; 67(5):1346-58. PMID: 1597717.
    Citations: 75     Fields:    Translation:AnimalsCells
  128. Mody I, Otis TS, Staley KJ, Köhr G. The balance between excitation and inhibition in dentate granule cells and its role in epilepsy. Epilepsy Res Suppl. 1992; 9:331-9. PMID: 1337447.
    Citations: 6     Fields:    Translation:AnimalsCells
  129. Mody I, Köhr G, Otis TS, Staley KJ. The electrophysiology of dentate gyrus granule cells in whole-cell recordings. Epilepsy Res Suppl. 1992; 7:159-68. PMID: 1334661.
    Citations: 8     Fields:    Translation:AnimalsCells
  130. Sofroniew MV, Staley K. Transgenic modelling of neurodegenerative events gathers momentum. Trends Neurosci. 1991 Dec; 14(12):513-4. PMID: 1726340.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  131. Staley KJ, Mody I. Integrity of perforant path fibers and the frequency of action potential independent excitatory and inhibitory synaptic events in dentate gyrus granule cells. Synapse. 1991 Nov; 9(3):219-24. PMID: 1837962.
    Citations: 5     Fields:    Translation:AnimalsCells
  132. Otis TS, Staley KJ, Mody I. Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release. Brain Res. 1991 Apr 05; 545(1-2):142-50. PMID: 1650273.
    Citations: 38     Fields:    Translation:AnimalsCells
  133. Staley K, Iragui V, Spitz M. The human fetal auditory evoked potential. Electroencephalogr Clin Neurophysiol. 1990 Jan-Feb; 77(1):1-5. PMID: 1688780.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.