Harvard Catalyst Profiles

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Kevin Joseph Staley, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35NS116852 (STALEY, KEVIN J.) May 1, 2020 - Apr 30, 2028
    Neuronal ion and volume shifts after acute brain injury
    Role: Principal Investigator
  2. R33NS096948 (STALEY, KEVIN J.) Jun 1, 2017 - Aug 31, 2021
    Anticonvulsant screening using chronic epilepsy models
    Role: Principal Investigator
  3. R21NS096948 (STALEY, KEVIN J.) Jun 1, 2017 - May 31, 2020
    Anticonvulsant screening using chronic epilepsy models
    Role: Principal Investigator
  4. U01MH106013 (STALEY, KEVIN J.) Sep 26, 2014 - May 31, 2018
    Mapping neuronal chloride microdomains
    Role: Principal Investigator
  5. R01NS086364 (STALEY, KEVIN J.) Sep 1, 2013 - Jan 31, 2020
    Biomarkers for epileptogenesis after brain injury
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lau LA, Staley KJ, Lillis KP. In vitro ictogenesis is stochastic at the single neuron level. Brain. 2021 Aug 25. PMID: 34431994.
    Citations:    Fields:    
  2. Galanopoulou AS, Löscher W, Lubbers L, O'Brien TJ, Staley K, Vezzani A, D'Ambrosio R, White HS, Sontheimer H, Wolf JA, Twyman R, Whittemore V, Wilcox KS, Klein B. Antiepileptogenesis and disease modification: Progress, challenges, and the path forward-Report of the Preclinical Working Group of the 2018 NINDS-sponsored antiepileptogenesis and disease modification workshop. Epilepsia Open. 2021 Jun; 6(2):276-296. PMID: 34033232.
    Citations: 2     
  3. Rahmati N, Normoyle KP, Glykys J, Dzhala VI, Lillis KP, Kahle KT, Raiyyani R, Jacob T, Staley KJ. Unique Actions of GABA Arising from Cytoplasmic Chloride Microdomains. J Neurosci. 2021 Jun 09; 41(23):4957-4975. PMID: 33903223.
    Citations:    Fields:    
  4. Costine-Bartell B, Price G, Shen J, McGuone D, Staley K, Duhaime AC. A perfect storm: The distribution of tissue damage depends on seizure duration, hemorrhage, and developmental stage in a gyrencephalic, multi-factorial, severe traumatic brain injury model. Neurobiol Dis. 2021 07; 154:105334. PMID: 33753291.
    Citations:    Fields:    
  5. Dzhala VI, Staley KJ. KCC2 Chloride Transport Contributes to the Termination of Ictal Epileptiform Activity. eNeuro. 2021 Mar-Apr; 8(2). PMID: 33239270.
    Citations: 1     Fields:    Translation:AnimalsCells
  6. Soul JS, Bergin AM, Stopp C, Hayes B, Singh A, Fortuno CR, O'Reilly D, Krishnamoorthy K, Jensen FE, Rofeberg V, Dong M, Vinks AA, Wypij D, Staley KJ. A Pilot Randomized, Controlled, Double-Blind Trial of Bumetanide to Treat Neonatal Seizures. Ann Neurol. 2021 02; 89(2):327-340. PMID: 33201535.
    Citations: 3     Fields:    Translation:Humans
  7. Cudkowicz M, Chase MK, Coffey CS, Ecklund DJ, Thornell BJ, Lungu C, Mahoney K, Gutmann L, Shefner JM, Staley KJ, Bosch M, Foster E, Long JD, Bayman EO, Torner J, Yankey J, Peters R, Huff T, Conwit RA, Shinnar S, Patch D, Darras BT, Ellis A, Packer RJ, Marder KS, Chiriboga CA, Henchcliffe C, Moran JA, Nikolov B, Factor SA, Seeley C, Greenberg SM, Amato AA, DeGregorio S, Simuni T, Ward T, Kissel JT, Kolb SJ, Bartlett A, Quinn JF, Keith K, Levine SR, Gilles N, Coyle PK, Lamb J, Wolfe GI, Crumlish A, Mejico L, Iqbal MM, Bowen JD, Tongco C, Nabors LB, Bashir K, Benge M, McDonald CM, Henricson EK, Oskarsson B, Dobkin BH, Canamar C, Glauser TA, Woo D, Molloy A, Clark P, Vollmer TL, Stein AJ, Barohn RJ, Dimachkie MM, Le Pichon JB, Benatar MG, Steele J, Wechsler L, Clemens PR, Amity C, Holloway RG, Annis C, Goldberg MP, Andersen M, Iannaccone ST, Smith AG, Singleton JR, Doudova M, Haley EC, Quigg MS, Lowenhaupt S, Malow BA, Adkins K, Clifford DB, Teshome MA, Connolly N. Seven-Year Experience From the National Institute of Neurological Disorders and Stroke-Supported Network for Excellence in Neuroscience Clinical Trials. JAMA Neurol. 2020 06 01; 77(6):755-763. PMID: 32202612.
    Citations: 2     Fields:    Translation:Humans
  8. Traynelis SF, Dlugos D, Henshall D, Mefford HC, Rogawski MA, Staley KJ, Dacks PA, Whittemore V, Poduri A. Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects. Epilepsy Curr. 2020 Jan-Feb; 20(1_suppl):23S-30S. PMID: 31965829.
    Citations: 3     
  9. Kramer MA, Ostrowski LM, Song DY, Thorn EL, Stoyell SM, Parnes M, Chinappen D, Xiao G, Eden UT, Staley KJ, Stufflebeam SM, Chu CJ. Scalp recorded spike ripples predict seizure risk in childhood epilepsy better than spikes. Brain. 2019 05 01; 142(5):1296-1309. PMID: 30907404.
    Citations: 12     Fields:    Translation:Humans
  10. Glykys J, Duquette E, Rahmati N, Duquette K, Staley KJ. Mannitol decreases neocortical epileptiform activity during early brain development via cotransport of chloride and water. Neurobiol Dis. 2019 05; 125:163-175. PMID: 30711483.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Jacob T, Lillis KP, Wang Z, Swiercz W, Rahmati N, Staley KJ. A Proposed Mechanism for Spontaneous Transitions between Interictal and Ictal Activity. J Neurosci. 2019 01 16; 39(3):557-575. PMID: 30446533.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Costine-Bartell BA, McGuone D, Price G, Crawford E, Keeley KL, Munoz-Pareja J, Dodge CP, Staley K, Duhaime AC. Development of a Model of Hemispheric Hypodensity ("Big Black Brain"). J Neurotrauma. 2019 03 01; 36(5):815-833. PMID: 30039743.
    Citations: 3     Fields:    Translation:Animals
  13. Blauwblomme T, Dzhala V, Staley K. Transient ischemia facilitates neuronal chloride accumulation and severity of seizures. Ann Clin Transl Neurol. 2018 Sep; 5(9):1048-1061. PMID: 30250862.
    Citations: 2     Fields:    
  14. Kim JA, Boyle EJ, Wu AC, Cole AJ, Staley KJ, Zafar S, Cash SS, Westover MB. Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy. Ann Neurol. 2018 04; 83(4):858-862. PMID: 29537656.
    Citations: 15     Fields:    Translation:Humans
  15. Lillis KP, Staley KJ. Optogenetic dissection of ictogenesis: in search of a targeted anti-epileptic therapy. J Neural Eng. 2018 08; 15(4):041001. PMID: 29536948.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Moyer JT, Gnatkovsky V, Ono T, Otáhal J, Wagenaar J, Stacey WC, Noebels J, Ikeda A, Staley K, de Curtis M, Litt B, Galanopoulou AS. Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 11; 58 Suppl 4:53-67. PMID: 29105070.
    Citations: 10     Fields:    Translation:Animals
  17. Glykys J, Dzhala V, Egawa K, Kahle KT, Delpire E, Staley K. Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential. Trends Neurosci. 2017 05; 40(5):276-294. PMID: 28431741.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  18. Liu J, Saponjian Y, Mahoney MM, Staley KJ, Berdichevsky Y. Epileptogenesis in organotypic hippocampal cultures has limited dependence on culture medium composition. PLoS One. 2017; 12(2):e0172677. PMID: 28225808.
    Citations: 6     Fields:    Translation:AnimalsCells
  19. Chu CJ, Chan A, Song D, Staley KJ, Stufflebeam SM, Kramer MA. A semi-automated method for rapid detection of ripple events on interictal voltage discharges in the scalp electroencephalogram. J Neurosci Methods. 2017 02 01; 277:46-55. PMID: 27988323.
    Citations: 4     Fields:    Translation:HumansAnimals
  20. Berdichevsky Y, Saponjian Y, Park KI, Roach B, Pouliot W, Lu K, Swiercz W, Dudek FE, Staley KJ. Staged anticonvulsant screening for chronic epilepsy. Ann Clin Transl Neurol. 2016 12; 3(12):908-923. PMID: 28097203.
    Citations: 6     Fields:    
  21. Song Y, Pimentel C, Walters K, Boller L, Ghiasvand S, Liu J, Staley KJ, Berdichevsky Y. Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury. Sci Rep. 2016 08 26; 6:32095. PMID: 27561791.
    Citations: 9     Fields:    Translation:AnimalsCells
  22. Glykys J, Staley KJ. Developmental Decrease of Neuronal Chloride Concentration Is Independent of Trauma in Thalamocortical Brain Slices. PLoS One. 2016; 11(6):e0158012. PMID: 27337272.
    Citations: 2     Fields:    Translation:AnimalsCells
  23. Kahle KT, Khanna AR, Duan J, Staley KJ, Delpire E, Poduri A. The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition. Neuroscientist. 2016 12; 22(6):555-562. PMID: 27130838.
    Citations: 24     Fields:    Translation:HumansAnimals
  24. Glykys J, Staley KJ. Diazepam effect during early neonatal development correlates with neuronal Cl(.). Ann Clin Transl Neurol. 2015 12; 2(12):1055-70. PMID: 26734658.
    Citations: 2     Fields:    
  25. Pitkänen A, Lukasiuk K, Dudek FE, Staley KJ. Epileptogenesis. Cold Spring Harb Perspect Med. 2015 Sep 18; 5(10). PMID: 26385090.
    Citations: 48     Fields:    Translation:HumansAnimals
  26. Lillis KP, Wang Z, Mail M, Zhao GQ, Berdichevsky Y, Bacskai B, Staley KJ. Evolution of Network Synchronization during Early Epileptogenesis Parallels Synaptic Circuit Alterations. J Neurosci. 2015 Jul 08; 35(27):9920-34. PMID: 26156993.
    Citations: 28     Fields:    Translation:AnimalsCells
  27. Trevelyan AJ, Muldoon SF, Merricks EM, Racca C, Staley KJ. The role of inhibition in epileptic networks. J Clin Neurophysiol. 2015 Jun; 32(3):227-34. PMID: 26035675.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  28. Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-Rachamimov A, Staley KJ. Failure to detect human papillomavirus in focal cortical dysplasia type IIb. Ann Neurol. 2015 Jul; 78(1):63-7. PMID: 25893423.
    Citations:    Fields:    Translation:HumansCells
  29. Park KI, Dzhala V, Saponjian Y, Staley KJ. What Elements of the Inflammatory System Are Necessary for Epileptogenesis In Vitro? eNeuro. 2015 Mar-Apr; 2(2). PMID: 26464976.
    Citations: 4     Fields:    
  30. Staley K. Molecular mechanisms of epilepsy. Nat Neurosci. 2015 Mar; 18(3):367-72. PMID: 25710839.
    Citations: 69     Fields:    Translation:HumansAnimals
  31. Dzhala V, Staley KJ. Acute and chronic efficacy of bumetanide in an in vitro model of posttraumatic epileptogenesis. CNS Neurosci Ther. 2015 Feb; 21(2):173-80. PMID: 25495911.
    Citations: 11     Fields:    Translation:Animals
  32. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science. 2014 Sep 05; 345(6201):1130. PMID: 25190789.
    Citations: 6     Fields:    Translation:AnimalsCells
  33. Delpire E, Staley KJ. Novel determinants of the neuronal Cl(-) concentration. J Physiol. 2014 Oct 01; 592(19):4099-114. PMID: 25107928.
    Citations: 19     Fields:    Translation:AnimalsCells
  34. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Local impermeant anions establish the neuronal chloride concentration. Science. 2014 Feb 07; 343(6171):670-5. PMID: 24503855.
    Citations: 75     Fields:    Translation:AnimalsCells
  35. Heinemann U, Staley KJ. What is the clinical relevance of in vitro epileptiform activity? Adv Exp Med Biol. 2014; 813:25-41. PMID: 25012364.
    Citations: 4     Fields:    Translation:Humans
  36. Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathol. 2014 Feb; 127(2):257-70. PMID: 24271788.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  37. Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Dudek FE. Epilepsy therapy development: technical and methodologic issues in studies with animal models. Epilepsia. 2013 Aug; 54 Suppl 4:13-23. PMID: 23909850.
    Citations: 17     Fields:    Translation:HumansAnimals
  38. O'Brien TJ, Ben-Menachem E, Bertram EH, Collins SD, Kokaia M, Lerche H, Klitgaard H, Staley KJ, Vaudano E, Walker MC, Simonato M. Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development. Epilepsia. 2013 Aug; 54 Suppl 4:70-4. PMID: 23909855.
    Citations: 6     Fields:    Translation:HumansAnimals
  39. Berdichevsky Y, Dryer AM, Saponjian Y, Mahoney MM, Pimentel CA, Lucini CA, Usenovic M, Staley KJ. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy. J Neurosci. 2013 May 22; 33(21):9056-67. PMID: 23699517.
    Citations: 37     Fields:    Translation:AnimalsCells
  40. Diao L, Hellier JL, Uskert-Newsom J, Williams PA, Staley KJ, Yee AS. Diphenytoin, riluzole and lidocaine: three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity. Neuropharmacology. 2013 Oct; 73:48-55. PMID: 23707481.
    Citations: 4     Fields:    Translation:Animals
  41. Dobelis P, Staley KJ, Cooper DC. Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. PLoS One. 2012; 7(7):e41108. PMID: 22848433.
    Citations: 16     Fields:    Translation:AnimalsCells
  42. Staley K. Neonatal encephalopathy, MRI lesions, and later epilepsy: no harm, no foul? Epilepsy Curr. 2012 Jul; 12(4):128-30. PMID: 22936880.
  43. Simonato M, Löscher W, Cole AJ, Dudek FE, Engel J, Kaminski RM, Loeb JA, Scharfman H, Staley KJ, Velíšek L, Klitgaard H. Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design. Epilepsia. 2012 Nov; 53(11):1860-7. PMID: 22708847.
    Citations: 26     Fields:    Translation:HumansAnimals
  44. Lillis KP, Kramer MA, Mertz J, Staley KJ, White JA. Pyramidal cells accumulate chloride at seizure onset. Neurobiol Dis. 2012 Sep; 47(3):358-66. PMID: 22677032.
    Citations: 47     Fields:    Translation:AnimalsCells
  45. Dzhala V, Valeeva G, Glykys J, Khazipov R, Staley K. Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain. J Neurosci. 2012 Mar 21; 32(12):4017-31. PMID: 22442068.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  46. Sabolek HR, Swiercz WB, Lillis KP, Cash SS, Huberfeld G, Zhao G, Ste Marie L, Clemenceau S, Barsh G, Miles R, Staley KJ. A candidate mechanism underlying the variance of interictal spike propagation. J Neurosci. 2012 Feb 29; 32(9):3009-21. PMID: 22378874.
    Citations: 26     Fields:    Translation:HumansAnimals
  47. Seker E, Berdichevsky Y, Staley KJ, Yarmush ML. Microfabrication-compatible nanoporous gold foams as biomaterials for drug delivery. Adv Healthc Mater. 2012 Mar; 1(2):172-6. PMID: 23184720.
    Citations: 9     Fields:    Translation:AnimalsCells
  48. Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia. 2012 Mar; 53(3):571-82. PMID: 22292566.
    Citations: 60     Fields:    Translation:HumansAnimals
  49. Dudek FE, Staley KJ. Seizure probability in animal models of acquired epilepsy: a perspective on the concept of the preictal state. Epilepsy Res. 2011 Dec; 97(3):324-31. PMID: 22094446.
    Citations: 7     Fields:    Translation:HumansAnimals
  50. Berdichevsky Y, Dzhala V, Mail M, Staley KJ. Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. Neurobiol Dis. 2012 Feb; 45(2):774-85. PMID: 22115940.
    Citations: 30     Fields:    Translation:Animals
  51. Staley K. Carts, Horses, and Push-Pull Regulation of EGABA in Neonatal Seizures. Epilepsy Curr. 2011 Nov; 11(6):205-8. PMID: 22129766.
    Citations: 1     
  52. Maa EH, Kahle KT, Walcott BP, Spitz MC, Staley KJ. Diuretics and epilepsy: will the past and present meet? Epilepsia. 2011 Sep; 52(9):1559-69. PMID: 21838793.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  53. Vandeventer S, Studnek JR, Garrett JS, Ward SR, Staley K, Blackwell T. The association between ambulance hospital turnaround times and patient acuity, destination hospital, and time of day. Prehosp Emerg Care. 2011 Jul-Sep; 15(3):366-70. PMID: 21480775.
    Citations: 5     Fields:    Translation:Humans
  54. Köhling R, Staley K. Network mechanisms for fast ripple activity in epileptic tissue. Epilepsy Res. 2011 Dec; 97(3):318-23. PMID: 21470826.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  55. Dudek FE, Staley KJ. The time course of acquired epilepsy: implications for therapeutic intervention to suppress epileptogenesis. Neurosci Lett. 2011 Jun 27; 497(3):240-6. PMID: 21458536.
    Citations: 27     Fields:    Translation:HumansAnimals
  56. Staley KJ, White A, Dudek FE. Interictal spikes: harbingers or causes of epilepsy? Neurosci Lett. 2011 Jun 27; 497(3):247-50. PMID: 21458535.
    Citations: 53     Fields:    Translation:HumansAnimals
  57. Kahle KT, Walcott BP, Staley KJ. Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport. J Child Neurol. 2011 Feb; 26(2):205-8. PMID: 21285039.
    Citations: 4     Fields:    Translation:Humans
  58. Dyhrfjeld-Johnsen J, Berdichevsky Y, Swiercz W, Sabolek H, Staley KJ. Interictal spikes precede ictal discharges in an organotypic hippocampal slice culture model of epileptogenesis. J Clin Neurophysiol. 2010 Dec; 27(6):418-24. PMID: 21076333.
    Citations: 53     Fields:    Translation:Animals
  59. Staley K. Stroke: recovery inhibitors under attack. Nature. 2010 Nov 11; 468(7321):176-7. PMID: 21068818.
    Citations: 2     Fields:    Translation:AnimalsCells
  60. Shin JH, Smith D, Swiercz W, Staley K, Rickard JT, Montero J, Kurgan LA, Cios KJ. Recognition of partially occluded and rotated images with a network of spiking neurons. IEEE Trans Neural Netw. 2010 Nov; 21(11):1697-709. PMID: 21047704.
    Citations: 3     Fields:    Translation:HumansCells
  61. Dzhala VI, Kuchibhotla KV, Glykys JC, Kahle KT, Swiercz WB, Feng G, Kuner T, Augustine GJ, Bacskai BJ, Staley KJ. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci. 2010 Sep 01; 30(35):11745-61. PMID: 20810895.
    Citations: 68     Fields:    Translation:AnimalsCells
  62. Studnek JR, Thestrup L, Vandeventer S, Ward SR, Staley K, Garvey L, Blackwell T. The association between prehospital endotracheal intubation attempts and survival to hospital discharge among out-of-hospital cardiac arrest patients. Acad Emerg Med. 2010 Sep; 17(9):918-25. PMID: 20836771.
    Citations: 14     Fields:    Translation:Humans
  63. Dredge DC, Parsons EC, Carter LP, Staley KJ. Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin. Pediatr Neurol. 2010 Jul; 43(1):65-9. PMID: 20682208.
    Citations: 1     Fields:    Translation:Humans
  64. Dudek FE, Pouliot WA, Rossi CA, Staley KJ. The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat. Epilepsia. 2010 Jul; 51 Suppl 3:126-30. PMID: 20618417.
    Citations: 9     Fields:    Translation:Animals
  65. Dudek FE, Ekstrand JJ, Staley KJ. Is neuronal death necessary for acquired epileptogenesis in the immature brain? Epilepsy Curr. 2010 Jul; 10(4):95-9. PMID: 20697505.
    Citations: 11     
  66. Seker E, Berdichevsky Y, Begley MR, Reed ML, Staley KJ, Yarmush ML. The fabrication of low-impedance nanoporous gold multiple-electrode arrays for neural electrophysiology studies. Nanotechnology. 2010 Mar 26; 21(12):125504. PMID: 20203356.
    Citations: 24     Fields:    Translation:AnimalsCells
  67. Berdichevsky Y, Staley KJ, Yarmush ML. Building and manipulating neural pathways with microfluidics. Lab Chip. 2010 Apr 21; 10(8):999-1004. PMID: 20358106.
    Citations: 26     Fields:    Translation:AnimalsCells
  68. Kadam SD, White AM, Staley KJ, Dudek FE. Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy. J Neurosci. 2010 Jan 06; 30(1):404-15. PMID: 20053921.
    Citations: 54     Fields:    Translation:Animals
  69. White A, Williams PA, Hellier JL, Clark S, Dudek FE, Staley KJ. EEG spike activity precedes epilepsy after kainate-induced status epilepticus. Epilepsia. 2010 Mar; 51(3):371-83. PMID: 19845739.
    Citations: 56     Fields:    Translation:HumansAnimals
  70. Glykys J, Dzhala VI, Kuchibhotla KV, Feng G, Kuner T, Augustine G, Bacskai BJ, Staley KJ. Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron. 2009 Sep 10; 63(5):657-72. PMID: 19755108.
    Citations: 63     Fields:    Translation:AnimalsCells
  71. Kahle KT, Simard JM, Staley KJ, Nahed BV, Jones PS, Sun D. Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport. Physiology (Bethesda). 2009 Aug; 24:257-65. PMID: 19675357.
    Citations: 72     Fields:    Translation:HumansAnimals
  72. Dulla CG, Frenguelli BG, Staley KJ, Masino SA. Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus. J Neurophysiol. 2009 Sep; 102(3):1984-93. PMID: 19625534.
    Citations: 18     Fields:    Translation:AnimalsCells
  73. Kahle KT, Barnett SM, Sassower KC, Staley KJ. Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1. J Child Neurol. 2009 May; 24(5):572-6. PMID: 19406757.
    Citations: 43     Fields:    Translation:Humans
  74. Williams PA, White AM, Clark S, Ferraro DJ, Swiercz W, Staley KJ, Dudek FE. Development of spontaneous recurrent seizures after kainate-induced status epilepticus. J Neurosci. 2009 Feb 18; 29(7):2103-12. PMID: 19228963.
    Citations: 144     Fields:    Translation:AnimalsCells
  75. Staley KJ, Anderson AE. Hyperactive interneurons impair learning in a neurofibromatosis model. Nat Neurosci. 2009 Jan; 12(1):8-10. PMID: 19107143.
    Citations: 1     Fields:    Translation:AnimalsCells
  76. Berdichevsky Y, Sabolek H, Levine JB, Staley KJ, Yarmush ML. Microfluidics and multielectrode array-compatible organotypic slice culture method. J Neurosci Methods. 2009 Mar 30; 178(1):59-64. PMID: 19100768.
    Citations: 19     Fields:    Translation:AnimalsCells
  77. Frey LC, Hellier J, Unkart C, Lepkin A, Howard A, Hasebroock K, Serkova N, Liang L, Patel M, Soltesz I, Staley K. A novel apparatus for lateral fluid percussion injury in the rat. J Neurosci Methods. 2009 Mar 15; 177(2):267-72. PMID: 19022291.
    Citations: 13     Fields:    Translation:Animals
  78. Hellier JL, White A, Williams PA, Dudek FE, Staley KJ. NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy. Neuropharmacology. 2009 Feb; 56(2):414-21. PMID: 18930747.
    Citations: 13     Fields:    Translation:Animals
  79. Staley KJ, Sims KB, Grant PE, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 28-2008. An 8-day-old infant with congenital deafness, lethargy, and hypothermia. N Engl J Med. 2008 Sep 11; 359(11):1156-67. PMID: 18784106.
    Citations:    Fields:    Translation:Humans
  80. Kahle KT, Staley KJ. The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Neurosurg Focus. 2008 Sep; 25(3):E22. PMID: 18759624.
    Citations: 31     Fields:    Translation:HumansAnimals
  81. Kahle KT, Staley KJ, Nahed BV, Gamba G, Hebert SC, Lifton RP, Mount DB. Roles of the cation-chloride cotransporters in neurological disease. Nat Clin Pract Neurol. 2008 Sep; 4(9):490-503. PMID: 18769373.
    Citations: 143     Fields:    Translation:HumansAnimals
  82. Staley KJ. Does plasticity of the GABA(A) reversal potential contribute to epileptogenesis? Epilepsy Curr. 2008 Jul-Aug; 8(4):107-10. PMID: 18596880.
    Citations: 2     
  83. Kahle KT, Staley K. Altered neuronal chloride homeostasis and excitatory GABAergic signaling in human temporal lobe epilepsy. Epilepsy Curr. 2008 Mar-Apr; 8(2):51-3. PMID: 18330470.
    Citations: 8     
  84. Brumback AC, Staley KJ. Thermodynamic regulation of NKCC1-mediated Cl- cotransport underlies plasticity of GABA(A) signaling in neonatal neurons. J Neurosci. 2008 Feb 06; 28(6):1301-12. PMID: 18256250.
    Citations: 47     Fields:    Translation:AnimalsCells
  85. Dzhala VI, Brumback AC, Staley KJ. Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. Ann Neurol. 2008 Feb; 63(2):222-35. PMID: 17918265.
    Citations: 98     Fields:    Translation:Animals
  86. Jarrett SG, Liang LP, Hellier JL, Staley KJ, Patel M. Mitochondrial DNA damage and impaired base excision repair during epileptogenesis. Neurobiol Dis. 2008 Apr; 30(1):130-8. PMID: 18295498.
    Citations: 39     Fields:    Translation:AnimalsCells
  87. Dudek FE, Bertram EH, Staley KJ. Antiepileptogenesis Therapy with Levetiracetam: Data from Kindling versus Status Epilepticus Models. Epilepsy Curr. 2008 Jan-Feb; 8(1):28-30. PMID: 18265888.
    Citations: 7     
  88. Staley KJ. Neurons skip a beat during fast ripples. Neuron. 2007 Sep 20; 55(6):828-30. PMID: 17880888.
    Citations: 7     Fields:    Translation:AnimalsCells
  89. Hellier JL, Grosshans DR, Coultrap SJ, Jones JP, Dobelis P, Browning MD, Staley KJ. NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network. J Neurophysiol. 2007 Nov; 98(5):2818-26. PMID: 17728388.
    Citations: 9     Fields:    Translation:AnimalsCells
  90. Dudek FE, Staley KJ. How does the balance of excitation and inhibition shift during epileptogenesis? Epilepsy Curr. 2007 May-Jun; 7(3):86-8. PMID: 17520084.
    Citations: 4     
  91. Swiercz W, Cios K, Hellier J, Yee A, Staley K. Effects of synaptic depression and recovery on synchronous network activity. J Clin Neurophysiol. 2007 Apr; 24(2):165-74. PMID: 17414972.
    Citations: 5     Fields:    Translation:AnimalsCells
  92. Jones J, Stubblefield EA, Benke TA, Staley KJ. Desynchronization of glutamate release prolongs synchronous CA3 network activity. J Neurophysiol. 2007 May; 97(5):3812-8. PMID: 17344368.
    Citations: 15     Fields:    Translation:AnimalsCells
  93. Schuyler R, White A, Staley K, Cios KJ. Epileptic seizure detection. IEEE Eng Med Biol Mag. 2007 Mar-Apr; 26(2):74-82. PMID: 17441611.
    Citations: 2     Fields:    Translation:Humans
  94. Williams PA, Hellier JL, White AM, Staley KJ, Dudek FE. Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis. Epilepsia. 2007; 48 Suppl 5:157-63. PMID: 17910596.
    Citations: 27     Fields:    Translation:HumansAnimals
  95. Soltesz I, Staley K. High times for memory: cannabis disrupts temporal coordination among hippocampal neurons. Nat Neurosci. 2006 Dec; 9(12):1461-3. PMID: 17128279.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  96. Staley KJ, Dudek FE. Interictal spikes and epileptogenesis. Epilepsy Curr. 2006 Nov-Dec; 6(6):199-202. PMID: 17260059.
    Citations: 60     
  97. Dudek FE, Staley KJ. Laser scanning photostimulation: new evidence for enhanced recurrent excitation in a model of posttraumatic epilepsy. Epilepsy Curr. 2006 Nov-Dec; 6(6):215-6. PMID: 17260064.
    Citations: 1     
  98. Staley KJ, Huguenard JR. A thalamic sleep tonic. Epilepsy Curr. 2006 Sep-Oct; 6(5):164-6. PMID: 17260047.
  99. Staley KJ. Wrong-way chloride transport: is it a treatable cause of some intractable seizures? Epilepsy Curr. 2006 Jul-Aug; 6(4):124-7. PMID: 17260033.
    Citations: 10     
  100. Prescott C, Weeks AM, Staley KJ, Partin KM. Kynurenic acid has a dual action on AMPA receptor responses. Neurosci Lett. 2006 Jul 10; 402(1-2):108-12. PMID: 16644124.
    Citations: 49     Fields:    Translation:AnimalsCells
  101. Williams P, White A, Ferraro D, Clark S, Staley K, Dudek FE. The use of radiotelemetry to evaluate electrographic seizures in rats with kainate-induced epilepsy. J Neurosci Methods. 2006 Jul 15; 155(1):39-48. PMID: 16564574.
    Citations: 18     Fields:    Translation:AnimalsCells
  102. Swiercz W, Cios KJ, Staley K, Kurgan L, Accurso F, Sagel S. A new synaptic plasticity rule for networks of spiking neurons. IEEE Trans Neural Netw. 2006 Jan; 17(1):94-105. PMID: 16526479.
    Citations: 3     Fields:    Translation:HumansCells
  103. Dulla CG, Dobelis P, Pearson T, Frenguelli BG, Staley KJ, Masino SA. Adenosine and ATP link PCO2 to cortical excitability via pH. Neuron. 2005 Dec 22; 48(6):1011-23. PMID: 16364904.
    Citations: 67     Fields:    Translation:AnimalsCells
  104. White AM, Williams PA, Ferraro DJ, Clark S, Kadam SD, Dudek FE, Staley KJ. Efficient unsupervised algorithms for the detection of seizures in continuous EEG recordings from rats after brain injury. J Neurosci Methods. 2006 Apr 15; 152(1-2):255-66. PMID: 16337006.
    Citations: 45     Fields:    Translation:Animals
  105. Dudek FE, Staley KJ. Chronic cortical injury and epileptogensis: a possible role for intracellular chloride homeostasis. Epilepsy Curr. 2005 Nov-Dec; 5(6):239-40. PMID: 16372061.
  106. Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke TA, Delpire E, Jensen FE, Staley KJ. NKCC1 transporter facilitates seizures in the developing brain. Nat Med. 2005 Nov; 11(11):1205-13. PMID: 16227993.
    Citations: 320     Fields:    Translation:HumansAnimals
  107. Staley K, Hellier JL, Dudek FE. Do interictal spikes drive epileptogenesis? Neuroscientist. 2005 Aug; 11(4):272-6. PMID: 16061513.
    Citations: 49     Fields:    Translation:HumansAnimals
  108. Staley K, Scharfman H. A woman's prerogative. Nat Neurosci. 2005 Jun; 8(6):697-9. PMID: 15917829.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  109. Dzhala VI, Staley KJ. Mechanisms of fast ripples in the hippocampus. J Neurosci. 2004 Oct 06; 24(40):8896-906. PMID: 15470156.
    Citations: 46     Fields:    Translation:AnimalsCells
  110. Staley K. Neuroscience. Epileptic neurons go wireless. Science. 2004 Jul 23; 305(5683):482-3. PMID: 15273382.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  111. Staley KJ. Role of the depolarizing GABA response in epilepsy. Adv Exp Med Biol. 2004; 548:104-9. PMID: 15250589.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  112. Staley K. Salt and wounds: a new mechanism for neuropathic pain. Nat Med. 2003 Sep; 9(9):1110-1. PMID: 12949519.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  113. Dzhala VI, Staley KJ. Transition from interictal to ictal activity in limbic networks in vitro. J Neurosci. 2003 Aug 27; 23(21):7873-80. PMID: 12944517.
    Citations: 49     Fields:    Translation:AnimalsCells
  114. Dzhala VI, Staley KJ. Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus. J Neurosci. 2003 Mar 01; 23(5):1840-6. PMID: 12629188.
    Citations: 55     Fields:    Translation:AnimalsCells
  115. Yee AS, Longacher JM, Staley KJ. Convulsant and anticonvulsant effects on spontaneous CA3 population bursts. J Neurophysiol. 2003 Jan; 89(1):427-41. PMID: 12522191.
    Citations: 6     Fields:    Translation:AnimalsCells
  116. Dudek FE, Staley KJ, Sutula TP. The search for animal models of epileptogenesis and pharmacoresistance: are there biologic barriers to simple validation strategies? Epilepsia. 2002 Nov; 43(11):1275-7. PMID: 12423376.
    Citations: 3     Fields:    Translation:Animals
  117. Staley KJ. Diuretics as Antiepileptic Drugs: Should We Go with the Flow? Epilepsy Curr. 2002 Mar; 2(2):35-38. PMID: 15309160.
    Citations: 6     
  118. Dudek FE, Hellier JL, Williams PA, Ferraro DJ, Staley KJ. The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus. Prog Brain Res. 2002; 135:53-65. PMID: 12143370.
    Citations: 30     Fields:    Translation:AnimalsCells
  119. Staley KJ, Bains JS, Yee A, Hellier J, Longacher JM. Statistical model relating CA3 burst probability to recovery from burst-induced depression at recurrent collateral synapses. J Neurophysiol. 2001 Dec; 86(6):2736-47. PMID: 11731533.
    Citations: 14     Fields:    Translation:AnimalsCells
  120. Staley K, Smith R. A new form of feedback at the GABA(A) receptor. Nat Neurosci. 2001 Jul; 4(7):674-6. PMID: 11426214.
    Citations: 11     Fields:    Translation:AnimalsCells
  121. Bercher DL, Staley K, Turner LW, Aitken M. Pediatric injuries resulting from use of all-terrain vehicles. J Ark Med Soc. 2001 Apr; 97(10):351-3. PMID: 11269970.
    Citations: 2     Fields:    Translation:Humans
  122. Smith RL, Traul DL, Schaack J, Clayton GH, Staley KJ, Wilcox CL. Characterization of promoter function and cell-type-specific expression from viral vectors in the nervous system. J Virol. 2000 Dec; 74(23):11254-61. PMID: 11070024.
    Citations: 17     Fields:    Translation:AnimalsCells
  123. Staley KJ, Proctor WR. Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport. J Physiol. 1999 Sep 15; 519 Pt 3:693-712. PMID: 10457084.
    Citations: 92     Fields:    Translation:AnimalsCells
  124. Bains JS, Longacher JM, Staley KJ. Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses. Nat Neurosci. 1999 Aug; 2(8):720-6. PMID: 10412061.
    Citations: 49     Fields:    Translation:AnimalsCells
  125. Staley KJ. Quantal GABA release: noise or not? Nat Neurosci. 1999 Jun; 2(6):494-5. PMID: 10448209.
    Citations: 4     Fields:    Translation:AnimalsCells
  126. Staley KJ, Longacher M, Bains JS, Yee A. Presynaptic modulation of CA3 network activity. Nat Neurosci. 1998 Jul; 1(3):201-9. PMID: 10195144.
    Citations: 45     Fields:    Translation:AnimalsCells
  127. Clayton GH, Staley KJ, Wilcox CL, Owens GC, Smith RL. Developmental expression of C1C-2 in the rat nervous system. Brain Res Dev Brain Res. 1998 Jun 15; 108(1-2):307-18. PMID: 9693808.
    Citations: 3     Fields:    Translation:Animals
  128. Hinks GL, Shah B, French SJ, Campos LS, Staley K, Hughes J, Sofroniew MV. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity. J Neurosci. 1997 Jul 15; 17(14):5549-59. PMID: 9204936.
    Citations: 21     Fields:    Translation:Animals
  129. Staley K, Smith R, Schaack J, Wilcox C, Jentsch TJ. Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel. Neuron. 1996 Sep; 17(3):543-51. PMID: 8816717.
    Citations: 57     Fields:    Translation:AnimalsCells
  130. Blaschke AJ, Staley K, Chun J. Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development. 1996 Apr; 122(4):1165-74. PMID: 8620843.
    Citations: 107     Fields:    Translation:AnimalsCells
  131. Staley KJ, Soldo BL, Proctor WR. Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science. 1995 Aug 18; 269(5226):977-81. PMID: 7638623.
    Citations: 190     Fields:    Translation:AnimalsCells
  132. Smith RL, Clayton GH, Wilcox CL, Escudero KW, Staley KJ. Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition. J Neurosci. 1995 May; 15(5 Pt 2):4057-67. PMID: 7751965.
    Citations: 35     Fields:    Translation:AnimalsCells
  133. Staley K. The role of an inwardly rectifying chloride conductance in postsynaptic inhibition. J Neurophysiol. 1994 Jul; 72(1):273-84. PMID: 7965011.
    Citations: 31     Fields:    Translation:AnimalsCells
  134. Mody I, Staley KJ. Cell properties in the epileptic hippocampus. Hippocampus. 1994 Jun; 4(3):275-80. PMID: 7531092.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  135. Svendsen CN, Kew JN, Staley K, Sofroniew MV. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J Neurosci. 1994 Jan; 14(1):75-87. PMID: 8283253.
    Citations: 11     Fields:    Translation:AnimalsCells
  136. Staley K. Enhancement of the excitatory actions of GABA by barbiturates and benzodiazepines. Neurosci Lett. 1992 Oct 26; 146(1):105-7. PMID: 1282225.
    Citations: 11     Fields:    Translation:AnimalsCells
  137. Staley KJ, Mody I. Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance. J Neurophysiol. 1992 Jul; 68(1):197-212. PMID: 1381418.
    Citations: 93     Fields:    Translation:AnimalsCells
  138. Staley KJ, Otis TS, Mody I. Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings. J Neurophysiol. 1992 May; 67(5):1346-58. PMID: 1597717.
    Citations: 87     Fields:    Translation:AnimalsCells
  139. Mody I, Otis TS, Staley KJ, Köhr G. The balance between excitation and inhibition in dentate granule cells and its role in epilepsy. Epilepsy Res Suppl. 1992; 9:331-9. PMID: 1337447.
    Citations: 7     Fields:    Translation:AnimalsCells
  140. Mody I, Köhr G, Otis TS, Staley KJ. The electrophysiology of dentate gyrus granule cells in whole-cell recordings. Epilepsy Res Suppl. 1992; 7:159-68. PMID: 1334661.
    Citations: 10     Fields:    Translation:AnimalsCells
  141. Sofroniew MV, Staley K. Transgenic modelling of neurodegenerative events gathers momentum. Trends Neurosci. 1991 Dec; 14(12):513-4. PMID: 1726340.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  142. Staley KJ, Mody I. Integrity of perforant path fibers and the frequency of action potential independent excitatory and inhibitory synaptic events in dentate gyrus granule cells. Synapse. 1991 Nov; 9(3):219-24. PMID: 1837962.
    Citations: 7     Fields:    Translation:AnimalsCells
  143. Otis TS, Staley KJ, Mody I. Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release. Brain Res. 1991 Apr 05; 545(1-2):142-50. PMID: 1650273.
    Citations: 43     Fields:    Translation:AnimalsCells
  144. Staley K, Iragui V, Spitz M. The human fetal auditory evoked potential. Electroencephalogr Clin Neurophysiol. 1990 Jan-Feb; 77(1):1-5. PMID: 1688780.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.