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profileKevin Joseph Staley, M.D.

TitleJoseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Neurology, WAC 708
55 Fruit St
Boston MA 02114
Fax617/643-0141
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Available: 07/01/17, Expires: 07/01/20

Perineural nets surround neurons and comprise an critical element of the brain's extracellular matrix. We are testing whether components of the perineural net (sulfated glycosaminoglycans) are present in the spinal fluid of patients with acute brain injury, and with degenerative disorders that cause brain atrophy.


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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21NS096948     (STALEY, KEVIN J.)Jun 1, 2017 - May 31, 2018
NIH/NINDS
Anticonvulsant screening using chronic epilepsy models
Role: Principal Investigator

U01MH106013     (STALEY, KEVIN J.)Sep 26, 2014 - Jun 30, 2017
NIH/NIMH
Mapping neuronal chloride microdomains
Role: Principal Investigator

R01NS086364     (STALEY, KEVIN J.)Sep 1, 2013 - May 31, 2018
NIH/NINDS
Biomarkers for epileptogenesis after brain injury
Role: Co-Principal Investigator

K12NS066225     (STALEY, KEVIN J.)Sep 1, 2011 - Aug 31, 2016
NIH/NINDS
Pediatric Neurology Physician Scientist Program.
Role: Principal Investigator

R37NS077908     (STALEY, KEVIN J.)Aug 1, 2011 - Jul 31, 2019
NIH/NINDS
Mechanisms of neuronal death during epileptogenesis
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Moyer JT, Gnatkovsky V, Ono T, Otáhal J, Wagenaar J, Stacey WC, Noebels J, Ikeda A, Staley K, de Curtis M, Litt B, Galanopoulou AS. Standards for data acquisition and software-based analysis of in vivo electroencephalography recordings from animals. A TASK1-WG5 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 2017 11; 58 Suppl 4:53-67. PMID: 29105070.
    View in: PubMed
  2. Glykys J, Dzhala V, Egawa K, Kahle KT, Delpire E, Staley K. Chloride Dysregulation, Seizures, and Cerebral Edema: A Relationship with Therapeutic Potential. Trends Neurosci. 2017 May; 40(5):276-294. PMID: 28431741.
    View in: PubMed
  3. Liu J, Saponjian Y, Mahoney MM, Staley KJ, Berdichevsky Y. Epileptogenesis in organotypic hippocampal cultures has limited dependence on culture medium composition. PLoS One. 2017; 12(2):e0172677. PMID: 28225808.
    View in: PubMed
  4. Chu CJ, Chan A, Song D, Staley KJ, Stufflebeam SM, Kramer MA. A semi-automated method for rapid detection of ripple events on interictal voltage discharges in the scalp electroencephalogram. J Neurosci Methods. 2017 Feb 01; 277:46-55. PMID: 27988323.
    View in: PubMed
  5. Berdichevsky Y, Saponjian Y, Park KI, Roach B, Pouliot W, Lu K, Swiercz W, Dudek FE, Staley KJ. Staged anticonvulsant screening for chronic epilepsy. Ann Clin Transl Neurol. 2016 Dec; 3(12):908-923. PMID: 28097203.
    View in: PubMed
  6. Song Y, Pimentel C, Walters K, Boller L, Ghiasvand S, Liu J, Staley KJ, Berdichevsky Y. Neuroprotective levels of IGF-1 exacerbate epileptogenesis after brain injury. Sci Rep. 2016 Aug 26; 6:32095. PMID: 27561791; PMCID: PMC4999804.
  7. Glykys J, Staley KJ. Developmental Decrease of Neuronal Chloride Concentration Is Independent of Trauma in Thalamocortical Brain Slices. PLoS One. 2016; 11(6):e0158012. PMID: 27337272; PMCID: PMC4919081.
  8. Kahle KT, Khanna AR, Duan J, Staley KJ, Delpire E, Poduri A. The KCC2 Cotransporter and Human Epilepsy: Getting Excited About Inhibition. Neuroscientist. 2016 Dec; 22(6):555-562. PMID: 27130838.
    View in: PubMed
  9. Glykys J, Staley KJ. Diazepam effect during early neonatal development correlates with neuronal Cl(.). Ann Clin Transl Neurol. 2015 Dec; 2(12):1055-70. PMID: 26734658; PMCID: PMC4693588.
  10. Pitkänen A, Lukasiuk K, Dudek FE, Staley KJ. Epileptogenesis. Cold Spring Harb Perspect Med. 2015 Sep 18; 5(10). PMID: 26385090.
    View in: PubMed
  11. Lillis KP, Wang Z, Mail M, Zhao GQ, Berdichevsky Y, Bacskai B, Staley KJ. Evolution of Network Synchronization during Early Epileptogenesis Parallels Synaptic Circuit Alterations. J Neurosci. 2015 Jul 08; 35(27):9920-34. PMID: 26156993; PMCID: PMC4495242.
  12. Trevelyan AJ, Muldoon SF, Merricks EM, Racca C, Staley KJ. The role of inhibition in epileptic networks. J Clin Neurophysiol. 2015 Jun; 32(3):227-34. PMID: 26035675.
    View in: PubMed
  13. Shapiro KA, McGuone D, Deshpande V, Sadow PM, Stemmer-Rachamimov A, Staley KJ. Failure to detect human papillomavirus in focal cortical dysplasia type IIb. Ann Neurol. 2015 Jul; 78(1):63-7. PMID: 25893423.
    View in: PubMed
  14. Park KI, Dzhala V, Saponjian Y, Staley KJ. What Elements of the Inflammatory System Are Necessary for Epileptogenesis In Vitro? eNeuro. 2015 Mar-Apr; 2(2). PMID: 26464976; PMCID: PMC4596089.
  15. Staley K. Molecular mechanisms of epilepsy. Nat Neurosci. 2015 Mar; 18(3):367-72. PMID: 25710839; PMCID: PMC4409128.
  16. Dzhala V, Staley KJ. Acute and chronic efficacy of bumetanide in an in vitro model of posttraumatic epileptogenesis. CNS Neurosci Ther. 2015 Feb; 21(2):173-80. PMID: 25495911; PMCID: PMC4391014.
  17. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Response to comments on "Local impermeant anions establish the neuronal chloride concentration". Science. 2014 Sep 05; 345(6201):1130. PMID: 25190789; PMCID: PMC4410268.
  18. Delpire E, Staley KJ. Novel determinants of the neuronal Cl(-) concentration. J Physiol. 2014 Oct 01; 592(19):4099-114. PMID: 25107928; PMCID: PMC4215762.
  19. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian Y, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Local impermeant anions establish the neuronal chloride concentration. Science. 2014 Feb 07; 343(6171):670-5. PMID: 24503855; PMCID: PMC4220679.
  20. Heinemann U, Staley KJ. What is the clinical relevance of in vitro epileptiform activity? Adv Exp Med Biol. 2014; 813:25-41. PMID: 25012364.
    View in: PubMed
  21. Polydoro M, Dzhala VI, Pooler AM, Nicholls SB, McKinney AP, Sanchez L, Pitstick R, Carlson GA, Staley KJ, Spires-Jones TL, Hyman BT. Soluble pathological tau in the entorhinal cortex leads to presynaptic deficits in an early Alzheimer's disease model. Acta Neuropathol. 2014 Feb; 127(2):257-70. PMID: 24271788; PMCID: PMC3946978.
  22. Galanopoulou AS, Kokaia M, Loeb JA, Nehlig A, Pitkänen A, Rogawski MA, Staley KJ, Whittemore VH, Dudek FE. Epilepsy therapy development: technical and methodologic issues in studies with animal models. Epilepsia. 2013 Aug; 54 Suppl 4:13-23. PMID: 23909850; PMCID: PMC3747731.
  23. O'Brien TJ, Ben-Menachem E, Bertram EH, Collins SD, Kokaia M, Lerche H, Klitgaard H, Staley KJ, Vaudano E, Walker MC, Simonato M. Proposal for a "phase II" multicenter trial model for preclinical new antiepilepsy therapy development. Epilepsia. 2013 Aug; 54 Suppl 4:70-4. PMID: 23909855.
    View in: PubMed
  24. Berdichevsky Y, Dryer AM, Saponjian Y, Mahoney MM, Pimentel CA, Lucini CA, Usenovic M, Staley KJ. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of post-traumatic epilepsy. J Neurosci. 2013 May 22; 33(21):9056-67. PMID: 23699517; PMCID: PMC3735438.
  25. Diao L, Hellier JL, Uskert-Newsom J, Williams PA, Staley KJ, Yee AS. Diphenytoin, riluzole and lidocaine: three sodium channel blockers, with different mechanisms of action, decrease hippocampal epileptiform activity. Neuropharmacology. 2013 Oct; 73:48-55. PMID: 23707481; PMCID: PMC3766392.
  26. Dobelis P, Staley KJ, Cooper DC. Lack of modulation of nicotinic acetylcholine alpha-7 receptor currents by kynurenic acid in adult hippocampal interneurons. PLoS One. 2012; 7(7):e41108. PMID: 22848433; PMCID: PMC3405093.
  27. Staley K. Neonatal encephalopathy, MRI lesions, and later epilepsy: no harm, no foul? Epilepsy Curr. 2012 Jul; 12(4):128-30. PMID: 22936880; PMCID: PMC3423207.
  28. Simonato M, Löscher W, Cole AJ, Dudek FE, Engel J, Kaminski RM, Loeb JA, Scharfman H, Staley KJ, Velíšek L, Klitgaard H. Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design. Epilepsia. 2012 Nov; 53(11):1860-7. PMID: 22708847; PMCID: PMC4208688.
  29. Lillis KP, Kramer MA, Mertz J, Staley KJ, White JA. Pyramidal cells accumulate chloride at seizure onset. Neurobiol Dis. 2012 Sep; 47(3):358-66. PMID: 22677032; PMCID: PMC3392473.
  30. Dzhala V, Valeeva G, Glykys J, Khazipov R, Staley K. Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain. J Neurosci. 2012 Mar 21; 32(12):4017-31. PMID: 22442068; PMCID: PMC3333790.
  31. Sabolek HR, Swiercz WB, Lillis KP, Cash SS, Huberfeld G, Zhao G, Ste Marie L, Clemenceau S, Barsh G, Miles R, Staley KJ. A candidate mechanism underlying the variance of interictal spike propagation. J Neurosci. 2012 Feb 29; 32(9):3009-21. PMID: 22378874; PMCID: PMC3319688.
  32. Seker E, Berdichevsky Y, Staley KJ, Yarmush ML. Microfabrication-compatible nanoporous gold foams as biomaterials for drug delivery. Adv Healthc Mater. 2012 Mar; 1(2):172-6. PMID: 23184720; PMCID: PMC3532581.
  33. Galanopoulou AS, Buckmaster PS, Staley KJ, Moshé SL, Perucca E, Engel J, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia. 2012 Mar; 53(3):571-82. PMID: 22292566; PMCID: PMC3551973.
  34. Dudek FE, Staley KJ. Seizure probability in animal models of acquired epilepsy: a perspective on the concept of the preictal state. Epilepsy Res. 2011 Dec; 97(3):324-31. PMID: 22094446.
    View in: PubMed
  35. Berdichevsky Y, Dzhala V, Mail M, Staley KJ. Interictal spikes, seizures and ictal cell death are not necessary for post-traumatic epileptogenesis in vitro. Neurobiol Dis. 2012 Feb; 45(2):774-85. PMID: 22115940; PMCID: PMC3786688.
  36. Staley K. Carts, Horses, and Push-Pull Regulation of EGABA in Neonatal Seizures. Epilepsy Curr. 2011 Nov; 11(6):205-8. PMID: 22129766; PMCID: PMC3220425.
  37. Maa EH, Kahle KT, Walcott BP, Spitz MC, Staley KJ. Diuretics and epilepsy: will the past and present meet? Epilepsia. 2011 Sep; 52(9):1559-69. PMID: 21838793.
    View in: PubMed
  38. Vandeventer S, Studnek JR, Garrett JS, Ward SR, Staley K, Blackwell T. The association between ambulance hospital turnaround times and patient acuity, destination hospital, and time of day. Prehosp Emerg Care. 2011 Jul-Sep; 15(3):366-70. PMID: 21480775.
    View in: PubMed
  39. Köhling R, Staley K. Network mechanisms for fast ripple activity in epileptic tissue. Epilepsy Res. 2011 Dec; 97(3):318-23. PMID: 21470826; PMCID: PMC3152631.
  40. Dudek FE, Staley KJ. The time course of acquired epilepsy: implications for therapeutic intervention to suppress epileptogenesis. Neurosci Lett. 2011 Jun 27; 497(3):240-6. PMID: 21458536.
    View in: PubMed
  41. Staley KJ, White A, Dudek FE. Interictal spikes: harbingers or causes of epilepsy? Neurosci Lett. 2011 Jun 27; 497(3):247-50. PMID: 21458535; PMCID: PMC3124147.
  42. Kahle KT, Walcott BP, Staley KJ. Resolution of headache and papilledema in idiopathic intracranial hypertension associated with inhibition of Na+-K+-2Cl- cotransport. J Child Neurol. 2011 Feb; 26(2):205-8. PMID: 21285039.
    View in: PubMed
  43. Dyhrfjeld-Johnsen J, Berdichevsky Y, Swiercz W, Sabolek H, Staley KJ. Interictal spikes precede ictal discharges in an organotypic hippocampal slice culture model of epileptogenesis. J Clin Neurophysiol. 2010 Dec; 27(6):418-24. PMID: 21076333; PMCID: PMC4167405.
  44. Staley K. Stroke: recovery inhibitors under attack. Nature. 2010 Nov 11; 468(7321):176-7. PMID: 21068818.
    View in: PubMed
  45. Shin JH, Smith D, Swiercz W, Staley K, Rickard JT, Montero J, Kurgan LA, Cios KJ. Recognition of partially occluded and rotated images with a network of spiking neurons. IEEE Trans Neural Netw. 2010 Nov; 21(11):1697-709. PMID: 21047704.
    View in: PubMed
  46. Dzhala VI, Kuchibhotla KV, Glykys JC, Kahle KT, Swiercz WB, Feng G, Kuner T, Augustine GJ, Bacskai BJ, Staley KJ. Progressive NKCC1-dependent neuronal chloride accumulation during neonatal seizures. J Neurosci. 2010 Sep 01; 30(35):11745-61. PMID: 20810895; PMCID: PMC3070296.
  47. Dredge DC, Parsons EC, Carter LP, Staley KJ. Anticonvulsant hypersensitivity syndrome treated with intravenous immunoglobulin. Pediatr Neurol. 2010 Jul; 43(1):65-9. PMID: 20682208.
    View in: PubMed
  48. Dudek FE, Pouliot WA, Rossi CA, Staley KJ. The effect of the cannabinoid-receptor antagonist, SR141716, on the early stage of kainate-induced epileptogenesis in the adult rat. Epilepsia. 2010 Jul; 51 Suppl 3:126-30. PMID: 20618417; PMCID: PMC2908914.
  49. Dudek FE, Ekstrand JJ, Staley KJ. Is neuronal death necessary for acquired epileptogenesis in the immature brain? Epilepsy Curr. 2010 Jul; 10(4):95-9. PMID: 20697505; PMCID: PMC2912542.
  50. Seker E, Berdichevsky Y, Begley MR, Reed ML, Staley KJ, Yarmush ML. The fabrication of low-impedance nanoporous gold multiple-electrode arrays for neural electrophysiology studies. Nanotechnology. 2010 Mar 26; 21(12):125504. PMID: 20203356; PMCID: PMC3136242.
  51. Berdichevsky Y, Staley KJ, Yarmush ML. Building and manipulating neural pathways with microfluidics. Lab Chip. 2010 Apr 21; 10(8):999-1004. PMID: 20358106; PMCID: PMC3137909.
  52. Kadam SD, White AM, Staley KJ, Dudek FE. Continuous electroencephalographic monitoring with radio-telemetry in a rat model of perinatal hypoxia-ischemia reveals progressive post-stroke epilepsy. J Neurosci. 2010 Jan 06; 30(1):404-15. PMID: 20053921; PMCID: PMC2903060.
  53. White A, Williams PA, Hellier JL, Clark S, Dudek FE, Staley KJ. EEG spike activity precedes epilepsy after kainate-induced status epilepticus. Epilepsia. 2010 Mar; 51(3):371-83. PMID: 19845739; PMCID: PMC2906396.
  54. Glykys J, Dzhala VI, Kuchibhotla KV, Feng G, Kuner T, Augustine G, Bacskai BJ, Staley KJ. Differences in cortical versus subcortical GABAergic signaling: a candidate mechanism of electroclinical uncoupling of neonatal seizures. Neuron. 2009 Sep 10; 63(5):657-72. PMID: 19755108; PMCID: PMC2932871.
  55. Kahle KT, Simard JM, Staley KJ, Nahed BV, Jones PS, Sun D. Molecular mechanisms of ischemic cerebral edema: role of electroneutral ion transport. Physiology (Bethesda). 2009 Aug; 24:257-65. PMID: 19675357.
    View in: PubMed
  56. Dulla CG, Frenguelli BG, Staley KJ, Masino SA. Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus. J Neurophysiol. 2009 Sep; 102(3):1984-93. PMID: 19625534; PMCID: PMC2746788.
  57. Kahle KT, Barnett SM, Sassower KC, Staley KJ. Decreased seizure activity in a human neonate treated with bumetanide, an inhibitor of the Na(+)-K(+)-2Cl(-) cotransporter NKCC1. J Child Neurol. 2009 May; 24(5):572-6. PMID: 19406757.
    View in: PubMed
  58. Williams PA, White AM, Clark S, Ferraro DJ, Swiercz W, Staley KJ, Dudek FE. Development of spontaneous recurrent seizures after kainate-induced status epilepticus. J Neurosci. 2009 Feb 18; 29(7):2103-12. PMID: 19228963; PMCID: PMC2897752.
  59. Staley KJ, Anderson AE. Hyperactive interneurons impair learning in a neurofibromatosis model. Nat Neurosci. 2009 Jan; 12(1):8-10. PMID: 19107143.
    View in: PubMed
  60. Berdichevsky Y, Sabolek H, Levine JB, Staley KJ, Yarmush ML. Microfluidics and multielectrode array-compatible organotypic slice culture method. J Neurosci Methods. 2009 Mar 30; 178(1):59-64. PMID: 19100768; PMCID: PMC2669279.
  61. Frey LC, Hellier J, Unkart C, Lepkin A, Howard A, Hasebroock K, Serkova N, Liang L, Patel M, Soltesz I, Staley K. A novel apparatus for lateral fluid percussion injury in the rat. J Neurosci Methods. 2009 Mar 15; 177(2):267-72. PMID: 19022291; PMCID: PMC3072895.
  62. Hellier JL, White A, Williams PA, Dudek FE, Staley KJ. NMDA receptor-mediated long-term alterations in epileptiform activity in experimental chronic epilepsy. Neuropharmacology. 2009 Feb; 56(2):414-21. PMID: 18930747; PMCID: PMC2698817.
  63. Staley KJ, Sims KB, Grant PE, Hedley-Whyte ET. Case records of the Massachusetts General Hospital. Case 28-2008. An 8-day-old infant with congenital deafness, lethargy, and hypothermia. N Engl J Med. 2008 Sep 11; 359(11):1156-67. PMID: 18784106.
    View in: PubMed
  64. Kahle KT, Staley KJ. The bumetanide-sensitive Na-K-2Cl cotransporter NKCC1 as a potential target of a novel mechanism-based treatment strategy for neonatal seizures. Neurosurg Focus. 2008 Sep; 25(3):E22. PMID: 18759624.
    View in: PubMed
  65. Kahle KT, Staley KJ, Nahed BV, Gamba G, Hebert SC, Lifton RP, Mount DB. Roles of the cation-chloride cotransporters in neurological disease. Nat Clin Pract Neurol. 2008 Sep; 4(9):490-503. PMID: 18769373.
    View in: PubMed
  66. Staley KJ. Does plasticity of the GABA(A) reversal potential contribute to epileptogenesis? Epilepsy Curr. 2008 Jul-Aug; 8(4):107-10. PMID: 18596880; PMCID: PMC2442156.
  67. Kahle KT, Staley K. Altered neuronal chloride homeostasis and excitatory GABAergic signaling in human temporal lobe epilepsy. Epilepsy Curr. 2008 Mar-Apr; 8(2):51-3. PMID: 18330470; PMCID: PMC2265806.
  68. Brumback AC, Staley KJ. Thermodynamic regulation of NKCC1-mediated Cl- cotransport underlies plasticity of GABA(A) signaling in neonatal neurons. J Neurosci. 2008 Feb 06; 28(6):1301-12. PMID: 18256250.
    View in: PubMed
  69. Dzhala VI, Brumback AC, Staley KJ. Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. Ann Neurol. 2008 Feb; 63(2):222-35. PMID: 17918265.
    View in: PubMed
  70. Jarrett SG, Liang LP, Hellier JL, Staley KJ, Patel M. Mitochondrial DNA damage and impaired base excision repair during epileptogenesis. Neurobiol Dis. 2008 Apr; 30(1):130-8. PMID: 18295498; PMCID: PMC2696045.
  71. Dudek FE, Bertram EH, Staley KJ. Antiepileptogenesis Therapy with Levetiracetam: Data from Kindling versus Status Epilepticus Models. Epilepsy Curr. 2008 Jan-Feb; 8(1):28-30. PMID: 18265888; PMCID: PMC2238642.
  72. Staley KJ. Neurons skip a beat during fast ripples. Neuron. 2007 Sep 20; 55(6):828-30. PMID: 17880888.
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  73. Hellier JL, Grosshans DR, Coultrap SJ, Jones JP, Dobelis P, Browning MD, Staley KJ. NMDA receptor trafficking at recurrent synapses stabilizes the state of the CA3 network. J Neurophysiol. 2007 Nov; 98(5):2818-26. PMID: 17728388.
    View in: PubMed
  74. Dudek FE, Staley KJ. How does the balance of excitation and inhibition shift during epileptogenesis? Epilepsy Curr. 2007 May-Jun; 7(3):86-8. PMID: 17520084; PMCID: PMC1874329.
  75. Swiercz W, Cios K, Hellier J, Yee A, Staley K. Effects of synaptic depression and recovery on synchronous network activity. J Clin Neurophysiol. 2007 Apr; 24(2):165-74. PMID: 17414972.
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  76. Jones J, Stubblefield EA, Benke TA, Staley KJ. Desynchronization of glutamate release prolongs synchronous CA3 network activity. J Neurophysiol. 2007 May; 97(5):3812-8. PMID: 17344368.
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  77. Schuyler R, White A, Staley K, Cios KJ. Epileptic seizure detection. IEEE Eng Med Biol Mag. 2007 Mar-Apr; 26(2):74-82. PMID: 17441611.
    View in: PubMed
  78. Williams PA, Hellier JL, White AM, Staley KJ, Dudek FE. Development of spontaneous seizures after experimental status epilepticus: implications for understanding epileptogenesis. Epilepsia. 2007; 48 Suppl 5:157-63. PMID: 17910596.
    View in: PubMed
  79. Soltesz I, Staley K. High times for memory: cannabis disrupts temporal coordination among hippocampal neurons. Nat Neurosci. 2006 Dec; 9(12):1461-3. PMID: 17128279.
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  80. Staley KJ, Dudek FE. Interictal spikes and epileptogenesis. Epilepsy Curr. 2006 Nov-Dec; 6(6):199-202. PMID: 17260059; PMCID: PMC1783497.
  81. Dudek FE, Staley KJ. Laser scanning photostimulation: new evidence for enhanced recurrent excitation in a model of posttraumatic epilepsy. Epilepsy Curr. 2006 Nov-Dec; 6(6):215-6. PMID: 17260064; PMCID: PMC1783486.
  82. Staley KJ, Huguenard JR. A thalamic sleep tonic. Epilepsy Curr. 2006 Sep-Oct; 6(5):164-6. PMID: 17260047; PMCID: PMC1783475.
  83. Staley KJ. Wrong-way chloride transport: is it a treatable cause of some intractable seizures? Epilepsy Curr. 2006 Jul-Aug; 6(4):124-7. PMID: 17260033; PMCID: PMC1783434.
  84. Prescott C, Weeks AM, Staley KJ, Partin KM. Kynurenic acid has a dual action on AMPA receptor responses. Neurosci Lett. 2006 Jul 10; 402(1-2):108-12. PMID: 16644124.
    View in: PubMed
  85. Williams P, White A, Ferraro D, Clark S, Staley K, Dudek FE. The use of radiotelemetry to evaluate electrographic seizures in rats with kainate-induced epilepsy. J Neurosci Methods. 2006 Jul 15; 155(1):39-48. PMID: 16564574.
    View in: PubMed
  86. Swiercz W, Cios KJ, Staley K, Kurgan L, Accurso F, Sagel S. A new synaptic plasticity rule for networks of spiking neurons. IEEE Trans Neural Netw. 2006 Jan; 17(1):94-105. PMID: 16526479.
    View in: PubMed
  87. Dulla CG, Dobelis P, Pearson T, Frenguelli BG, Staley KJ, Masino SA. Adenosine and ATP link PCO2 to cortical excitability via pH. Neuron. 2005 Dec 22; 48(6):1011-23. PMID: 16364904; PMCID: PMC1924599.
  88. White AM, Williams PA, Ferraro DJ, Clark S, Kadam SD, Dudek FE, Staley KJ. Efficient unsupervised algorithms for the detection of seizures in continuous EEG recordings from rats after brain injury. J Neurosci Methods. 2006 Apr 15; 152(1-2):255-66. PMID: 16337006.
    View in: PubMed
  89. Dudek FE, Staley KJ. Chronic cortical injury and epileptogensis: a possible role for intracellular chloride homeostasis. Epilepsy Curr. 2005 Nov-Dec; 5(6):239-40. PMID: 16372061; PMCID: PMC1312743.
  90. Dzhala VI, Talos DM, Sdrulla DA, Brumback AC, Mathews GC, Benke TA, Delpire E, Jensen FE, Staley KJ. NKCC1 transporter facilitates seizures in the developing brain. Nat Med. 2005 Nov; 11(11):1205-13. PMID: 16227993.
    View in: PubMed
  91. Staley K, Hellier JL, Dudek FE. Do interictal spikes drive epileptogenesis? Neuroscientist. 2005 Aug; 11(4):272-6. PMID: 16061513.
    View in: PubMed
  92. Staley K, Scharfman H. A woman's prerogative. Nat Neurosci. 2005 Jun; 8(6):697-9. PMID: 15917829.
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  93. Dzhala VI, Staley KJ. Mechanisms of fast ripples in the hippocampus. J Neurosci. 2004 Oct 06; 24(40):8896-906. PMID: 15470156.
    View in: PubMed
  94. Staley K. Neuroscience. Epileptic neurons go wireless. Science. 2004 Jul 23; 305(5683):482-3. PMID: 15273382.
    View in: PubMed
  95. Staley KJ. Role of the depolarizing GABA response in epilepsy. Adv Exp Med Biol. 2004; 548:104-9. PMID: 15250589.
    View in: PubMed
  96. Staley K. Salt and wounds: a new mechanism for neuropathic pain. Nat Med. 2003 Sep; 9(9):1110-1. PMID: 12949519.
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  97. Dzhala VI, Staley KJ. Transition from interictal to ictal activity in limbic networks in vitro. J Neurosci. 2003 Aug 27; 23(21):7873-80. PMID: 12944517.
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  98. Dzhala VI, Staley KJ. Excitatory actions of endogenously released GABA contribute to initiation of ictal epileptiform activity in the developing hippocampus. J Neurosci. 2003 Mar 01; 23(5):1840-6. PMID: 12629188.
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  99. Yee AS, Longacher JM, Staley KJ. Convulsant and anticonvulsant effects on spontaneous CA3 population bursts. J Neurophysiol. 2003 Jan; 89(1):427-41. PMID: 12522191.
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  100. Dudek FE, Staley KJ, Sutula TP. The search for animal models of epileptogenesis and pharmacoresistance: are there biologic barriers to simple validation strategies? Epilepsia. 2002 Nov; 43(11):1275-7. PMID: 12423376.
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  101. Staley KJ. Diuretics as Antiepileptic Drugs: Should We Go with the Flow? Epilepsy Curr. 2002 Mar; 2(2):35-38. PMID: 15309160.
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  102. Dudek FE, Hellier JL, Williams PA, Ferraro DJ, Staley KJ. The course of cellular alterations associated with the development of spontaneous seizures after status epilepticus. Prog Brain Res. 2002; 135:53-65. PMID: 12143370.
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  103. Staley KJ, Bains JS, Yee A, Hellier J, Longacher JM. Statistical model relating CA3 burst probability to recovery from burst-induced depression at recurrent collateral synapses. J Neurophysiol. 2001 Dec; 86(6):2736-47. PMID: 11731533.
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  104. Staley K, Smith R. A new form of feedback at the GABA(A) receptor. Nat Neurosci. 2001 Jul; 4(7):674-6. PMID: 11426214.
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  105. Smith RL, Traul DL, Schaack J, Clayton GH, Staley KJ, Wilcox CL. Characterization of promoter function and cell-type-specific expression from viral vectors in the nervous system. J Virol. 2000 Dec; 74(23):11254-61. PMID: 11070024; PMCID: PMC113226.
  106. Staley KJ, Proctor WR. Modulation of mammalian dendritic GABA(A) receptor function by the kinetics of Cl- and HCO3- transport. J Physiol. 1999 Sep 15; 519 Pt 3:693-712. PMID: 10457084; PMCID: PMC2269533.
  107. Bains JS, Longacher JM, Staley KJ. Reciprocal interactions between CA3 network activity and strength of recurrent collateral synapses. Nat Neurosci. 1999 Aug; 2(8):720-6. PMID: 10412061.
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  108. Staley KJ. Quantal GABA release: noise or not? Nat Neurosci. 1999 Jun; 2(6):494-5. PMID: 10448209.
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  109. Staley KJ, Longacher M, Bains JS, Yee A. Presynaptic modulation of CA3 network activity. Nat Neurosci. 1998 Jul; 1(3):201-9. PMID: 10195144.
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  110. Clayton GH, Staley KJ, Wilcox CL, Owens GC, Smith RL. Developmental expression of C1C-2 in the rat nervous system. Brain Res Dev Brain Res. 1998 Jun 15; 108(1-2):307-18. PMID: 9693808.
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  111. Hinks GL, Shah B, French SJ, Campos LS, Staley K, Hughes J, Sofroniew MV. Expression of LIM protein genes Lmo1, Lmo2, and Lmo3 in adult mouse hippocampus and other forebrain regions: differential regulation by seizure activity. J Neurosci. 1997 Jul 15; 17(14):5549-59. PMID: 9204936.
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  112. Staley K, Smith R, Schaack J, Wilcox C, Jentsch TJ. Alteration of GABAA receptor function following gene transfer of the CLC-2 chloride channel. Neuron. 1996 Sep; 17(3):543-51. PMID: 8816717.
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  113. Staley KJ, Soldo BL, Proctor WR. Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors. Science. 1995 Aug 18; 269(5226):977-81. PMID: 7638623.
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  114. Smith RL, Clayton GH, Wilcox CL, Escudero KW, Staley KJ. Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: a potential mechanism for cell-specific modulation of postsynaptic inhibition. J Neurosci. 1995 May; 15(5 Pt 2):4057-67. PMID: 7751965.
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  115. Staley K. The role of an inwardly rectifying chloride conductance in postsynaptic inhibition. J Neurophysiol. 1994 Jul; 72(1):273-84. PMID: 7965011.
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  116. Mody I, Staley KJ. Cell properties in the epileptic hippocampus. Hippocampus. 1994 Jun; 4(3):275-80. PMID: 7531092.
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  117. Svendsen CN, Kew JN, Staley K, Sofroniew MV. Death of developing septal cholinergic neurons following NGF withdrawal in vitro: protection by protein synthesis inhibition. J Neurosci. 1994 Jan; 14(1):75-87. PMID: 8283253.
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  118. Staley K. Enhancement of the excitatory actions of GABA by barbiturates and benzodiazepines. Neurosci Lett. 1992 Oct 26; 146(1):105-7. PMID: 1282225.
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  119. Staley KJ, Mody I. Shunting of excitatory input to dentate gyrus granule cells by a depolarizing GABAA receptor-mediated postsynaptic conductance. J Neurophysiol. 1992 Jul; 68(1):197-212. PMID: 1381418.
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  120. Staley KJ, Otis TS, Mody I. Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings. J Neurophysiol. 1992 May; 67(5):1346-58. PMID: 1597717.
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  121. Mody I, Otis TS, Staley KJ, Köhr G. The balance between excitation and inhibition in dentate granule cells and its role in epilepsy. Epilepsy Res Suppl. 1992; 9:331-9. PMID: 1337447.
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  122. Mody I, Köhr G, Otis TS, Staley KJ. The electrophysiology of dentate gyrus granule cells in whole-cell recordings. Epilepsy Res Suppl. 1992; 7:159-68. PMID: 1334661.
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  123. Sofroniew MV, Staley K. Transgenic modelling of neurodegenerative events gathers momentum. Trends Neurosci. 1991 Dec; 14(12):513-4. PMID: 1726340.
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  124. Staley KJ, Mody I. Integrity of perforant path fibers and the frequency of action potential independent excitatory and inhibitory synaptic events in dentate gyrus granule cells. Synapse. 1991 Nov; 9(3):219-24. PMID: 1837962.
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  125. Otis TS, Staley KJ, Mody I. Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release. Brain Res. 1991 Apr 05; 545(1-2):142-50. PMID: 1650273.
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  126. Staley K, Iragui V, Spitz M. The human fetal auditory evoked potential. Electroencephalogr Clin Neurophysiol. 1990 Jan-Feb; 77(1):1-5. PMID: 1688780.
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