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Steven P. Gygi, Ph.D.

Co-Author

This page shows the publications co-authored by Steven Gygi and Mark Jedrychowski.
Connection Strength

5.687
  1. Evaluation of HCD- and CID-type fragmentation within their respective detection platforms for murine phosphoproteomics. Mol Cell Proteomics. 2011 Dec; 10(12):M111.009910.
    View in: PubMed
    Score: 0.512
  2. Facultative protein selenation regulates redox sensitivity, adipose tissue thermogenesis, and obesity. Proc Natl Acad Sci U S A. 2020 05 19; 117(20):10789-10796.
    View in: PubMed
    Score: 0.233
  3. Sample multiplexing for targeted pathway proteomics in aging mice. Proc Natl Acad Sci U S A. 2020 05 05; 117(18):9723-9732.
    View in: PubMed
    Score: 0.233
  4. Correction to Characterization and Optimization of Multiplexed Quantitative Analyses Using High-Field Asymmetric-Waveform Ion Mobility Mass Spectrometry. Anal Chem. 2020 Mar 17; 92(6):4690.
    View in: PubMed
    Score: 0.230
  5. Quantitative Proteomics of the Cancer Cell Line Encyclopedia. Cell. 2020 01 23; 180(2):387-402.e16.
    View in: PubMed
    Score: 0.229
  6. Characterization and Optimization of Multiplexed Quantitative Analyses Using High-Field Asymmetric-Waveform Ion Mobility Mass Spectrometry. Anal Chem. 2019 03 19; 91(6):4010-4016.
    View in: PubMed
    Score: 0.215
  7. Multiplexed Isobaric Tag-Based Profiling of Seven Murine Tissues Following In Vivo Nicotine Treatment Using a Minimalistic Proteomics Strategy. Proteomics. 2018 05; 18(10):e1700326.
    View in: PubMed
    Score: 0.203
  8. Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes. Cell Syst. 2016 10 26; 3(4):395-403.e4.
    View in: PubMed
    Score: 0.181
  9. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Mol Metab. 2015 Nov; 4(11):758-70.
    View in: PubMed
    Score: 0.169
  10. Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. Cell Metab. 2015 Oct 06; 22(4):734-740.
    View in: PubMed
    Score: 0.168
  11. Evaluating multiplexed quantitative phosphopeptide analysis on a hybrid quadrupole mass filter/linear ion trap/orbitrap mass spectrometer. Anal Chem. 2015 Jan 20; 87(2):1241-9.
    View in: PubMed
    Score: 0.161
  12. MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes. Anal Chem. 2014 Jul 15; 86(14):7150-8.
    View in: PubMed
    Score: 0.155
  13. Increasing the multiplexing capacity of TMTs using reporter ion isotopologues with isobaric masses. Anal Chem. 2012 Sep 04; 84(17):7469-78.
    View in: PubMed
    Score: 0.137
  14. A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23; 143(7):1174-89.
    View in: PubMed
    Score: 0.122
  15. Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling. J Biol Chem. 2010 Jan 01; 285(1):104-14.
    View in: PubMed
    Score: 0.112
  16. Cellular spelunking: exploring adipocyte caveolae. J Lipid Res. 2007 Oct; 48(10):2103-11.
    View in: PubMed
    Score: 0.095
  17. Large-scale characterization of HeLa cell nuclear phosphoproteins. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12130-5.
    View in: PubMed
    Score: 0.078
  18. Peroxisomal-derived ether phospholipids link nucleotides to respirasome assembly. Nat Chem Biol. 2021 Mar 15.
    View in: PubMed
    Score: 0.062
  19. A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation. Cell Metab. 2021 Mar 02; 33(3):598-614.e7.
    View in: PubMed
    Score: 0.062
  20. Enrichment of Neurodegenerative Microglia Signature in Brain-Derived Extracellular Vesicles Isolated from Alzheimer's Disease Mouse Models. J Proteome Res. 2021 03 05; 20(3):1733-1743.
    View in: PubMed
    Score: 0.061
  21. Tetracyclines promote survival and fitness in mitochondrial disease models. Nat Metab. 2021 01; 3(1):33-42.
    View in: PubMed
    Score: 0.061
  22. Global proteomics of Ubqln2-based murine models of ALS. J Biol Chem. 2020 Dec 04.
    View in: PubMed
    Score: 0.061
  23. Proteomic Profiling of Extracellular Vesicles Derived from Cerebrospinal Fluid of Alzheimer's Disease Patients: A Pilot Study. Cells. 2020 08 25; 9(9).
    View in: PubMed
    Score: 0.060
  24. Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death. Nat Commun. 2020 06 01; 11(1):2714.
    View in: PubMed
    Score: 0.059
  25. A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging. Cell. 2020 03 05; 180(5):968-983.e24.
    View in: PubMed
    Score: 0.058
  26. Proteomic Profiling of Extracellular Vesicles Isolated From Cerebrospinal Fluid of Former National Football League Players at Risk for Chronic Traumatic Encephalopathy. Front Neurosci. 2019; 13:1059.
    View in: PubMed
    Score: 0.056
  27. ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes through the PERK-eIF2a Axis. Mol Cell. 2019 06 06; 74(5):877-890.e6.
    View in: PubMed
    Score: 0.054
  28. Multiplexed Relative Quantitation with Isobaric Tagging Mass Spectrometry Reveals Class I Major Histocompatibility Complex Ligand Dynamics in Response to Doxorubicin. Anal Chem. 2019 04 16; 91(8):5106-5115.
    View in: PubMed
    Score: 0.054
  29. Apolipoprotein E is a pancreatic extracellular factor that maintains mature ß-cell gene expression. PLoS One. 2018; 13(10):e0204595.
    View in: PubMed
    Score: 0.052
  30. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018 08; 560(7716):102-106.
    View in: PubMed
    Score: 0.051
  31. Inhibition of the ER stress IRE1a inflammatory pathway protects against cell death in mitochondrial complex I mutant cells. Cell Death Dis. 2018 05 31; 9(6):658.
    View in: PubMed
    Score: 0.051
  32. Cardiolipin Synthesis in Brown and Beige Fat Mitochondria Is Essential for Systemic Energy Homeostasis. Cell Metab. 2018 Jul 03; 28(1):159-174.e11.
    View in: PubMed
    Score: 0.051
  33. Characterization of Plasmodium falciparum Atypical Kinase PfPK7- Dependent Phosphoproteome. J Proteome Res. 2018 06 01; 17(6):2112-2123.
    View in: PubMed
    Score: 0.051
  34. Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes. Mol Metab. 2018 06; 12:25-38.
    View in: PubMed
    Score: 0.050
  35. Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition. Mol Cell. 2017 Aug 03; 67(3):512-527.e4.
    View in: PubMed
    Score: 0.048
  36. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Rep. 2017 07 18; 20(3):721-736.
    View in: PubMed
    Score: 0.048
  37. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):7981-7986.
    View in: PubMed
    Score: 0.048
  38. ERRa Maintains Mitochondrial Oxidative Metabolism and Constitutes an Actionable Target in PGC1a-Elevated Melanomas. Mol Cancer Res. 2017 10; 15(10):1366-1375.
    View in: PubMed
    Score: 0.048
  39. Selective Chemical Inhibition of PGC-1a Gluconeogenic Activity Ameliorates Type 2 Diabetes. Cell. 2017 03 23; 169(1):148-160.e15.
    View in: PubMed
    Score: 0.047
  40. Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization. Cell. 2016 11 03; 167(4):985-1000.e21.
    View in: PubMed
    Score: 0.046
  41. Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations. Mol Cell. 2016 10 06; 64(1):163-175.
    View in: PubMed
    Score: 0.045
  42. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes Dev. 2016 08 15; 30(16):1822-36.
    View in: PubMed
    Score: 0.045
  43. The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Cell. 2016 Jul 14; 166(2):424-435.
    View in: PubMed
    Score: 0.045
  44. Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. 2016 08 18; 536(7616):360.
    View in: PubMed
    Score: 0.044
  45. Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. 2016 04 07; 532(7597):112-6.
    View in: PubMed
    Score: 0.044
  46. The Methionine Transamination Pathway Controls Hepatic Glucose Metabolism through Regulation of the GCN5 Acetyltransferase and the PGC-1a Transcriptional Coactivator. J Biol Chem. 2016 May 13; 291(20):10635-45.
    View in: PubMed
    Score: 0.044
  47. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016 Mar 08; 23(3):454-66.
    View in: PubMed
    Score: 0.043
  48. Targeting miR-155 restores dysfunctional microglia and ameliorates disease in the SOD1 model of ALS. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5.
    View in: PubMed
    Score: 0.043
  49. Identification of a unique molecular and functional microglia signature in health and disease. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5.
    View in: PubMed
    Score: 0.043
  50. REMOVED: Identification of a unique molecular and functional microglia signature in health and disease. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5.
    View in: PubMed
    Score: 0.043
  51. REMOVED: Targeting miR-155 restores dysfunctional microglia and ameliorates disease in the SOD1 model of ALS. Int J Dev Neurosci. 2015 Dec; 47(Pt A):5.
    View in: PubMed
    Score: 0.043
  52. A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell. 2015 Oct 22; 163(3):643-55.
    View in: PubMed
    Score: 0.043
  53. eIF1A augments Ago2-mediated Dicer-independent miRNA biogenesis and RNA interference. Nat Commun. 2015 May 28; 6:7194.
    View in: PubMed
    Score: 0.041
  54. Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice. Ann Neurol. 2015 Jan; 77(1):75-99.
    View in: PubMed
    Score: 0.040
  55. Quantitative Proteomics Reveal a Feedforward Model for Mitochondrial PARKIN Translocation and Ubiquitin Chain Synthesis. Mol Cell. 2014 Nov 6; 56(3):462.
    View in: PubMed
    Score: 0.040
  56. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15756-61.
    View in: PubMed
    Score: 0.040
  57. Thrap3 docks on phosphoserine 273 of PPAR? and controls diabetic gene programming. Genes Dev. 2014 Nov 01; 28(21):2361-9.
    View in: PubMed
    Score: 0.040
  58. Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis. Mol Cell. 2014 Nov 06; 56(3):360-75.
    View in: PubMed
    Score: 0.040
  59. Corrigendum: Identification of a unique TGF-ß-dependent molecular and functional signature in microglia. Nat Neurosci. 2014 Aug 26; 17(9):1286.
    View in: PubMed
    Score: 0.039
  60. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 2014 Jun 05; 157(6):1279-1291.
    View in: PubMed
    Score: 0.039
  61. Post-translational regulation via Clp protease is critical for survival of Mycobacterium tuberculosis. PLoS Pathog. 2014 Mar; 10(3):e1003994.
    View in: PubMed
    Score: 0.038
  62. Cdc2-like kinase 2 suppresses hepatic fatty acid oxidation and ketogenesis through disruption of the PGC-1a and MED1 complex. Diabetes. 2014 May; 63(5):1519-32.
    View in: PubMed
    Score: 0.038
  63. Identification of a unique TGF-ß-dependent molecular and functional signature in microglia. Nat Neurosci. 2014 Jan; 17(1):131-43.
    View in: PubMed
    Score: 0.037
  64. Global analysis of protein expression and phosphorylation of three stages of Plasmodium falciparum intraerythrocytic development. J Proteome Res. 2013 Sep 06; 12(9):4028-45.
    View in: PubMed
    Score: 0.037
  65. Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12480-5.
    View in: PubMed
    Score: 0.036
  66. The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol Cell. 2012 Dec 28; 48(6):900-13.
    View in: PubMed
    Score: 0.035
  67. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Jan 11; 481(7382):463-8.
    View in: PubMed
    Score: 0.033
  68. The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol Cell. 2011 Dec 23; 44(6):851-63.
    View in: PubMed
    Score: 0.033
  69. MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. J Cell Biol. 2009 Jun 29; 185(7):1259-73.
    View in: PubMed
    Score: 0.027
  70. Role of insulin-dependent cortical fodrin/spectrin remodeling in glucose transporter 4 translocation in rat adipocytes. Mol Biol Cell. 2006 Oct; 17(10):4249-56.
    View in: PubMed
    Score: 0.022
  71. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006 Feb; 4(2):e38.
    View in: PubMed
    Score: 0.022
  72. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 2004 Mar 26; 303(5666):2011-5.
    View in: PubMed
    Score: 0.019
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.