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Phillip Zhe Sun, Ph.D.

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Overview
My research is to develop and apply novel MRI technique to improve our understanding of human diseases for early diagnosis and treatment. In particular, I have been focusing on imaging ischemic penumbra (the viable tissue under the risk of infarction if not reperfused promptly) using the recently developed pH sensitive endogenous amide proton transfer (APT) MRI. Conventionally, perfusion (PWI) and diffusion (DWI) imaging can demarcate ischemic core from hypoperfused area, which contains both ischemic penumbra and benign oligaemia. As the thrombolytic treatment increases the risk of hemorrhage and has neurotoxic side effects, it is crucial to detect the ischemic penumbra to assist treatment decision. Previously, we showed that pH MRI, in complimentary to PWI and DWI can delineate the ischemic tissue into core, penumbra and benign oligaemia, and the pH lesion is closely correlated with the 24hr infarction using a permanent animal stroke model. Encouraged by the animal study, we have implemented and optimized the APT imaging on clinical scanners, and are currently evaluating its effectiveness in detecting salvageable ischemic tissue on acute and subacute stroke patients. We will also develop and validate an infarction prediction model that integrates multi-parametric MRI of the hemodynamic, metabolic, structural and temporal status of ischemic tissue, and the ultimate goal is to develop MRI guided acute stroke therapy.

I am also interested in advancing the new chemical exchange dependent saturation transfer (CEST) imaging for specific molecular and cellular MRI. In comparison with conventional relaxation based contrast agents, the CEST agents can be incorporated into cellular proteins and provide enormous amplification of dilute labile groups. We will develop sensitive CEST agents that specifically bind to cell surface markers and explore the CEST imaging as a new method for cell tracking and functional imaging.

Moreover, I am developing advanced diffusion MRI technique such as diffusion imaging with ultra-short diffusion time. Although diffusion MRI has found tremendous applications such as white matter fiber tracking and detection of early stroke lesion, one of the technical limits is that the diffusion time is usually very long, tens of milliseconds, therefore the diffusion imaging is susceptible to transmembrane exchange and displacement restriction. By developing a diffusion MRI of ultra-short diffusion time, we can provide “genuine” diffusion contrast of microscopic water mobility and therefore improve our understanding of diffusion change in response tissue damage. In addition, I am also exploring a hybrid MRI technique that integrates the magnetization transfer and intravoxel incoherent motion (IVIM) mechanism as a new technique for endogenous cerebral blood volume (CBV) imaging.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AR071529 (SUN, PHILLIP ZHE) Jun 15, 2018 - May 31, 2020
    NIH/NIAMS
    Development of glycogen MRI for monitoring of Pompe disease progression
    Role: Principal Investigator
  2. R21NS085574 (SUN, PHILLIP ZHE) Sep 15, 2013 - Aug 31, 2015
    NIH/NINDS
    Development of kurtosis MRI to image acute stroke patients
    Role: Principal Investigator
  3. R01NS083654 (SUN, PHILLIP ZHE) Jul 1, 2013 - Apr 30, 2018
    NIH/NINDS
    Establishment of fast pH MRI for imaging metabolic injury during acute stroke
    Role: Principal Investigator
  4. K01EB009771 (SUN, PHILLIP ZHE) Sep 30, 2009 - Aug 31, 2014
    NIH/NIBIB
    Quantitate and validate an endogenous ph magnetic resonance imaging technique
    Role: Principal Investigator
  5. R21NS061119 (SORENSEN, ALMA GREGORY) Jul 1, 2008 - Jun 30, 2011
    NIH/NINDS
    Translation of pH-weighted MRI to Image Human Acute Stroke
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang E, Wu Y, Cheung JS, Igarashi T, Wu L, Zhang X, Sun PZ. Mapping tissue pH in an experimental model of acute stroke - Determination of graded regional tissue pH changes with non-invasive quantitative amide proton transfer MRI. Neuroimage. 2019 Feb 10. PMID: 30753926.
    Citations:    
  2. Wu Y, Chen Y, Zhao Y, Yang S, Zhao J, Zhou J, Chen Z, Sun PZ, Zheng H. Direct radiofrequency saturation corrected amide proton transfer tumor MRI at 3T. Magn Reson Med. 2019 Apr; 81(4):2710-2719. PMID: 30390326.
    Citations:    Fields:    
  3. Ji Y, Lu D, Wu L, Qiu B, Song YQ, Sun PZ. Preliminary evaluation of accelerated microscopic diffusional kurtosis imaging (µDKI) in a rodent model of epilepsy. Magn Reson Imaging. 2019 Feb; 56:90-95. PMID: 30352270.
    Citations:    Fields:    
  4. Ji Y, Paulsen J, Zhou IY, Lu D, Machado P, Qiu B, Song YQ, Sun PZ. In vivo microscopic diffusional kurtosis imaging with symmetrized double diffusion encoding EPI. Magn Reson Med. 2019 Jan; 81(1):533-541. PMID: 30260504.
    Citations:    Fields:    
  5. Zhou IY, Lu D, Ji Y, Wu L, Wang E, Cheung JS, Zhang XA, Sun PZ. Determination of multipool contributions to endogenous amide proton transfer effects in global ischemia with high spectral resolution in vivo chemical exchange saturation transfer MRI. Magn Reson Med. 2019 Jan; 81(1):645-652. PMID: 30058148.
    Citations:    Fields:    
  6. Jing B, Liu B, Li H, Lei J, Wang Z, Yang Y, Sun PZ, Xue B, Liu H, Xu ZD. Within-subject test-retest reliability of the atlas-based cortical volume measurement in the rat brain: A voxel-based morphometry study. J Neurosci Methods. 2018 Sep 01; 307:46-52. PMID: 29960027.
    Citations:    Fields:    
  7. Ye J, Fu G, Yan X, Liu J, Wang X, Cheng L, Zhang F, Sun PZ, Liu G. Noninvasive magnetic resonance/photoacoustic imaging for photothermal therapy response monitoring. Nanoscale. 2018 Mar 29; 10(13):5864-5868. PMID: 29560489.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Yin J, Sun H, Wang Z, Ni H, Shen W, Sun PZ. Diffusion Kurtosis Imaging of Acute Infarction: Comparison with Routine Diffusion and Follow-up MR Imaging. Radiology. 2018 05; 287(2):651-657. PMID: 29558293.
    Citations: 1     Fields:    Translation:Humans
  9. Lu D, Jiang Y, Ji Y, Zhou IY, Mandeville E, Lo EH, Wang X, Sun PZ. JOURNAL CLUB: Evaluation of Diffusion Kurtosis Imaging of Stroke Lesion With Hemodynamic and Metabolic MRI in a Rodent Model of Acute Stroke. AJR Am J Roentgenol. 2018 Apr; 210(4):720-727. PMID: 29470156.
    Citations:    Fields:    
  10. Yuwen Zhou I, Wang E, Cheung JS, Lu D, Ji Y, Zhang X, Fulci G, Sun PZ. Direct saturation-corrected chemical exchange saturation transfer MRI of glioma: Simplified decoupling of amide proton transfer and nuclear overhauser effect contrasts. Magn Reson Med. 2017 Dec; 78(6):2307-2314. PMID: 29030880.
    Citations: 1     Fields:    Translation:Animals
  11. Wang E, Wu Y, Cheung JS, Zhou IY, Igarashi T, Zhang X, Sun PZ. pH imaging reveals worsened tissue acidification in diffusion kurtosis lesion than the kurtosis/diffusion lesion mismatch in an animal model of acute stroke. J Cereb Blood Flow Metab. 2017 Oct; 37(10):3325-3333. PMID: 28752790.
    Citations: 2     Fields:    Translation:AnimalsCells
  12. Wu Y, Zhou IY, Lu D, Manderville E, Lo EH, Zheng H, Sun PZ. pH-sensitive amide proton transfer effect dominates the magnetization transfer asymmetry contrast during acute ischemia-quantification of multipool contribution to in vivo CEST MRI. Magn Reson Med. 2018 03; 79(3):1602-1608. PMID: 28733991.
    Citations: 1     Fields:    
  13. Wu Y, Zhou IY, Igarashi T, Longo DL, Aime S, Sun PZ. A generalized ratiometric chemical exchange saturation transfer (CEST) MRI approach for mapping renal pH using iopamidol. Magn Reson Med. 2018 03; 79(3):1553-1558. PMID: 28686805.
    Citations: 1     Fields:    
  14. Zhou IY, Wang E, Cheung JS, Zhang X, Fulci G, Sun PZ. Quantitative chemical exchange saturation transfer (CEST) MRI of glioma using Image Downsampling Expedited Adaptive Least-squares (IDEAL) fitting. Sci Rep. 2017 03 07; 7(1):84. PMID: 28273886.
    Citations: 9     Fields:    Translation:AnimalsCells
  15. Sun PZ, Ayata C, Lo EH. Fleeting footprints: finding MRI biomarkers of transient ischaemic attack. Brain. 2017 01; 140(1):8-10. PMID: 28031217.
    Citations:    Fields:    Translation:Humans
  16. Zhou IY, Fuss TL, Igarashi T, Jiang W, Zhou X, Cheng LL, Sun PZ. Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy. Anal Chem. 2016 11 01; 88(21):10379-10383. PMID: 27709896.
    Citations:    Fields:    Translation:Animals
  17. Zhou IY, Guo Y, Igarashi T, Wang Y, Mandeville E, Chan ST, Wen L, Vangel M, Lo EH, Ji X, Sun PZ. Fast diffusion kurtosis imaging (DKI) with Inherent COrrelation-based Normalization (ICON) enhances automatic segmentation of heterogeneous diffusion MRI lesion in acute stroke. NMR Biomed. 2016 12; 29(12):1670-1677. PMID: 27696558.
    Citations: 4     Fields:    Translation:Animals
  18. Guo Y, Zhou IY, Chan ST, Wang Y, Mandeville ET, Igarashi T, Lo EH, Ji X, Sun PZ. pH-sensitive MRI demarcates graded tissue acidification during acute stroke - pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI. Neuroimage. 2016 Nov 01; 141:242-249. PMID: 27444569; PMCID: PMC5026952.
    Citations: 11     Fields:    Translation:Animals
  19. Jiang W, Zhou IY, Wen L, Zhou X, Sun PZ. A theoretical analysis of chemical exchange saturation transfer echo planar imaging (CEST-EPI) steady state solution and the CEST sensitivity efficiency-based optimization approach. Contrast Media Mol Imaging. 2016 09; 11(5):415-423. PMID: 27312932.
    Citations: 1     Fields:    
  20. Longo DL, Michelotti F, Consolino L, Bardini P, Digilio G, Xiao G, Sun PZ, Aime S. In Vitro and In Vivo Assessment of Nonionic Iodinated Radiographic Molecules as Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Tumor Perfusion Agents. Invest Radiol. 2016 Mar; 51(3):155-62. PMID: 26460826.
    Citations: 2     Fields:    Translation:Animals
  21. Wu Y, Kim J, Chan ST, Zhou IY, Guo Y, Igarashi T, Zheng H, Guo G, Sun PZ. Comparison of image sensitivity between conventional tensor-based and fast diffusion kurtosis imaging protocols in a rodent model of acute ischemic stroke. NMR Biomed. 2016 May; 29(5):625-30. PMID: 26918411; PMCID: PMC4833647.
    Citations: 6     Fields:    Translation:Animals
  22. Sun PZ, Xiao G, Zhou IY, Guo Y, Wu R. A method for accurate pH mapping with chemical exchange saturation transfer (CEST) MRI. Contrast Media Mol Imaging. 2016 05; 11(3):195-202. PMID: 26689424.
    Citations: 4     Fields:    
  23. Xiao G, Sun PZ, Wu R. Fast simulation and optimization of pulse-train chemical exchange saturation transfer (CEST) imaging. Phys Med Biol. 2015 Jun 21; 60(12):4719-30. PMID: 26020414; PMCID: PMC4555213.
    Citations: 3     Fields:    Translation:Humans
  24. Wu R, Longo DL, Aime S, Sun PZ. Quantitative description of radiofrequency (RF) power-based ratiometric chemical exchange saturation transfer (CEST) pH imaging. NMR Biomed. 2015 May; 28(5):555-65. PMID: 25807919; PMCID: PMC4423622.
    Citations: 7     Fields:    
  25. Wu R, Xiao G, Zhou IY, Ran C, Sun PZ. Quantitative chemical exchange saturation transfer (qCEST) MRI - omega plot analysis of RF-spillover-corrected inverse CEST ratio asymmetry for simultaneous determination of labile proton ratio and exchange rate. NMR Biomed. 2015 Mar; 28(3):376-83. PMID: 25615718; PMCID: PMC4339459.
    Citations: 8     Fields:    
  26. Kim J, Wu Y, Guo Y, Zheng H, Sun PZ. A review of optimization and quantification techniques for chemical exchange saturation transfer MRI toward sensitive in vivo imaging. Contrast Media Mol Imaging. 2015 May-Jun; 10(3):163-178. PMID: 25641791; PMCID: PMC4469549.
    Citations: 9     Fields:    Translation:Cells
  27. Longo DL, Sun PZ, Consolino L, Michelotti FC, Uggeri F, Aime S. A general MRI-CEST ratiometric approach for pH imaging: demonstration of in vivo pH mapping with iobitridol. J Am Chem Soc. 2014 Oct 15; 136(41):14333-6. PMID: 25238643; PMCID: PMC4210149.
    Citations: 24     Fields:    Translation:AnimalsCells
  28. Sun PZ, Wang Y, Mandeville E, Chan ST, Lo EH, Ji X. Validation of fast diffusion kurtosis MRI for imaging acute ischemia in a rodent model of stroke. NMR Biomed. 2014 Nov; 27(11):1413-8. PMID: 25208309; PMCID: PMC4201862.
    Citations: 13     Fields:    Translation:Animals
  29. Sun PZ, Longo DL, Hu W, Xiao G, Wu R. Quantification of iopamidol multi-site chemical exchange properties for ratiometric chemical exchange saturation transfer (CEST) imaging of pH. Phys Med Biol. 2014 Aug 21; 59(16):4493-504. PMID: 25054859; PMCID: PMC4139413.
    Citations: 7     Fields:    
  30. Sun PZ, Wang Y, Dai Z, Xiao G, Wu R. Quantitative chemical exchange saturation transfer (qCEST) MRI--RF spillover effect-corrected omega plot for simultaneous determination of labile proton fraction ratio and exchange rate. Contrast Media Mol Imaging. 2014 Jul-Aug; 9(4):268-75. PMID: 24706610; PMCID: PMC4003506.
    Citations: 14     Fields:    Translation:Humans
  31. Sun PZ, Wang Y, Lu J. Sensitivity-enhanced chemical exchange saturation transfer (CEST) MRI with least squares optimization of Carr Purcell Meiboom Gill multi-echo echo planar imaging. Contrast Media Mol Imaging. 2014 Mar-Apr; 9(2):177-81. PMID: 24523063; PMCID: PMC3957332.
    Citations: 9     Fields:    Translation:Humans
  32. Sun PZ, Lu J, Wu Y, Xiao G, Wu R. Evaluation of the dependence of CEST-EPI measurement on repetition time, RF irradiation duty cycle and imaging flip angle for enhanced pH sensitivity. Phys Med Biol. 2013 Sep 07; 58(17):N229-40. PMID: 23939228; PMCID: PMC3811139.
    Citations: 16     Fields:    
  33. Sun PZ, Wang Y, Xiao G, Wu R. Simultaneous experimental determination of labile proton fraction ratio and exchange rate with irradiation radio frequency power-dependent quantitative CEST MRI analysis. Contrast Media Mol Imaging. 2013 May-Jun; 8(3):246-51. PMID: 23606428; PMCID: PMC4034529.
    Citations: 12     Fields:    
  34. Cheung JS, Wang E, Lo EH, Sun PZ. Stratification of heterogeneous diffusion MRI ischemic lesion with kurtosis imaging: evaluation of mean diffusion and kurtosis MRI mismatch in an animal model of transient focal ischemia. Stroke. 2012 Aug; 43(8):2252-4. PMID: 22773558; PMCID: PMC3412055.
    Citations: 30     Fields:    Translation:Animals
  35. Wu R, Liu CM, Liu PK, Sun PZ. Improved measurement of labile proton concentration-weighted chemical exchange rate (k(ws)) with experimental factor-compensated and T(1) -normalized quantitative chemical exchange saturation transfer (CEST) MRI. Contrast Media Mol Imaging. 2012 Jul-Aug; 7(4):384-9. PMID: 22649044; PMCID: PMC3415239.
    Citations: 20     Fields:    
  36. Zhang L, Jiang B, Wu Y, Strouthos C, Sun PZ, Su J, Zhou X. Developing a multiscale, multi-resolution agent-based brain tumor model by graphics processing units. Theor Biol Med Model. 2011 Dec 16; 8:46. PMID: 22176732; PMCID: PMC3312859.
    Citations: 7     Fields:    Translation:HumansCells
  37. Sun PZ, Wang E, Cheung JS. Imaging acute ischemic tissue acidosis with pH-sensitive endogenous amide proton transfer (APT) MRI--correction of tissue relaxation and concomitant RF irradiation effects toward mapping quantitative cerebral tissue pH. Neuroimage. 2012 Mar; 60(1):1-6. PMID: 22178815; PMCID: PMC3288866.
    Citations: 39     Fields:    Translation:Animals
  38. Sun PZ. Simplified quantification of labile proton concentration-weighted chemical exchange rate (k(ws) ) with RF saturation time dependent ratiometric analysis (QUESTRA): normalization of relaxation and RF irradiation spillover effects for improved quantitative chemical exchange saturation transfer (CEST) MRI. Magn Reson Med. 2012 Apr; 67(4):936-42. PMID: 21842497; PMCID: PMC3417060.
    Citations: 23     Fields:    
  39. Cheung JS, Wang E, Zhang X, Mandeville E, Lo EH, Sorensen AG, Sun PZ. Fast radio-frequency enforced steady state (FRESS) spin echo MRI for quantitative T2 mapping: minimizing the apparent repetition time (TR) dependence for fast T2 measurement. NMR Biomed. 2012 Feb; 25(2):189-94. PMID: 21755552; PMCID: PMC3712835.
    Citations: 9     Fields:    Translation:Animals
  40. Sun PZ, Wang E, Cheung JS, Zhang X, Benner T, Sorensen AG. Simulation and optimization of pulsed radio frequency irradiation scheme for chemical exchange saturation transfer (CEST) MRI-demonstration of pH-weighted pulsed-amide proton CEST MRI in an animal model of acute cerebral ischemia. Magn Reson Med. 2011 Oct; 66(4):1042-8. PMID: 21437977; PMCID: PMC3135736.
    Citations: 27     Fields:    Translation:Animals
  41. Sun PZ, Cheung JS, Wang E, Lo EH. Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke. J Cereb Blood Flow Metab. 2011 Aug; 31(8):1743-50. PMID: 21386856; PMCID: PMC3170940.
    Citations: 41     Fields:    Translation:Animals
  42. Sun PZ, Benner T, Copen WA, Sorensen AG. Early experience of translating pH-weighted MRI to image human subjects at 3 Tesla. Stroke. 2010 Oct; 41(10 Suppl):S147-51. PMID: 20876492; PMCID: PMC2956603.
    Citations: 32     Fields:    Translation:HumansAnimals
  43. Sun PZ, Cheung JS, Wang E, Benner T, Sorensen AG. Fast multislice pH-weighted chemical exchange saturation transfer (CEST) MRI with Unevenly segmented RF irradiation. Magn Reson Med. 2011 Feb; 65(2):588-94. PMID: 20872859; PMCID: PMC3145541.
    Citations: 25     Fields:    Translation:Animals
  44. Sun PZ. Simplified and scalable numerical solution for describing multi-pool chemical exchange saturation transfer (CEST) MRI contrast. J Magn Reson. 2010 Aug; 205(2):235-41. PMID: 20570196; PMCID: PMC2902598.
    Citations: 28     Fields:    
  45. Jin G, Sun PZ, Singhal AB, Ayata C, Lo EH. First-order mathematical modeling of brain swelling in focal cerebral ischemia. Transl Stroke Res. 2010 Mar; 1(1):65-70. PMID: 24323451.
    Citations: 2     Fields:    
  46. Sun PZ. Simultaneous determination of labile proton concentration and exchange rate utilizing optimal RF power: Radio frequency power (RFP) dependence of chemical exchange saturation transfer (CEST) MRI. J Magn Reson. 2010 Feb; 202(2):155-61. PMID: 19926319; PMCID: PMC2818407.
    Citations: 28     Fields:    
  47. Sun PZ, Benner T, Kumar A, Sorensen AG. Investigation of optimizing and translating pH-sensitive pulsed-chemical exchange saturation transfer (CEST) imaging to a 3T clinical scanner. Magn Reson Med. 2008 Oct; 60(4):834-41. PMID: 18816867; PMCID: PMC2678923.
    Citations: 61     Fields:    
  48. Sun PZ, Sorensen AG. Imaging pH using the chemical exchange saturation transfer (CEST) MRI: Correction of concomitant RF irradiation effects to quantify CEST MRI for chemical exchange rate and pH. Magn Reson Med. 2008 Aug; 60(2):390-7. PMID: 18666128.
    Citations: 45     Fields:    
  49. Salhotra A, Lal B, Laterra J, Sun PZ, van Zijl PC, Zhou J. Amide proton transfer imaging of 9L gliosarcoma and human glioblastoma xenografts. NMR Biomed. 2008 Jun; 21(5):489-97. PMID: 17924591; PMCID: PMC2943209.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  50. Sun PZ, Benner T, Sorensen AG. An Investigation of Optimizing and Translating Pulsed-Chemical Exchange Saturation Transfer (CEST) Imaging to a 3 T Clinical Scanner. 16th ISMRM. 2008.
  51. Sun PZ, Farrar C, Sorensen AG. Correction for Artifacts Induced by B0 and B1 Field Inhomogeneities in Chemical Exchange Saturation Transfer (CEST) MRI. 16th ISMRM. 2008.
  52. Sun PZ, Murata Y, Lu J, Wang X, Lo EH, Sorensen AG. Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke. Magn Reson Med. 2008 May; 59(5):1175-82. PMID: 18429031.
    Citations: 33     Fields:    Translation:Animals
  53. Zhu HH, Liu JX, Murata Y, Yu ZY, Sun PZ, Lu J, Lo EH, Wang XY. Annesin II combined with low dose tPA improves neurological outcomes in embolic stroke model of rats. American Heart Association, International Stroke Conference. 2008.
  54. Song YQ, Cho H, Hopper T, Pomerantz AE, Sun PZ. Magnetic resonance in porous media: recent progress. J Chem Phys. 2008 Feb 07; 128(5):052212. PMID: 18266417.
    Citations: 8     Fields:    
  55. Sun PZ, Farrar CT, Sorensen AG. Correction for artifacts induced by B(0) and B(1) field inhomogeneities in pH-sensitive chemical exchange saturation transfer (CEST) imaging. Magn Reson Med. 2007 Dec; 58(6):1207-15. PMID: 17969015.
    Citations: 53     Fields:    
  56. Hua J, van Zijl P, Sun PZ, Zhou J. Quantitative Description of Magnetization Transfer (MT) Asymmetry in Experimental Brain Tumors. Proc. Intl. Soc. Mag. Reson. Med. 15. 2007; 882.
  57. Zhou J, Salhotra A, Sun PZ, Lal B, Laterra J, van Zijl, P. Amide Proton Transfer Imaging and Magnetization Transfer Imaging for Characterizing Rat Brain Tumors. Proc. Intl. Soc. Mag. Reson. Med. 15. 2007; 2996.
  58. Sun PZ, Sorensen AG. Improved Quantification of Diffusion in Heterogeneous Systems Using the New Magic Asymmetric Gradient (MAG) Technique. Proc. Intl. Soc. Mag. Reson. Med. 15. 2007; 3540.
  59. Sun PZ, Zhou J, Huang J, Benner T, Sorensen AG, van Zijl P. Amide Proton Transfer (APT) Imaging Using Saturation Transfer Versus Inversion Transfer -- Which Is Better?. Proc. Intl. Soc. Mag. Reson. Med. 15. 2007; 3455.
  60. Sun PZ, Zhou J, Mcmahon M, van Zijl P . Optimal Properties of Chemical Exchange Saturation Transfer (CEST) Contrast Agents. Proc. Intl. Soc. Mag. Reson. Med. 15. 2007; 3404.
  61. Sun PZ. Improved diffusion measurement in heterogeneous systems using the magic asymmetric gradient stimulated echo (MAGSTE) technique. J Magn Reson. 2007 Aug; 187(2):177-83. PMID: 17500019; PMCID: PMC2075361.
    Citations: 1     Fields:    Translation:Cells
  62. Sun PZ, Huang J, Zhou JY, van Zijl P and Sorensen AG. pH sensitive MRI as a new imaging signature for acute ischemia. 31st Annual MGH Research Symposium and Poster Session. 2007; 12.
  63. Sun PZ, Zhou J, Huang J, van Zijl P. Simplified quantitative description of amide proton transfer (APT) imaging during acute ischemia. Magn Reson Med. 2007 Feb; 57(2):405-10. PMID: 17260362.
    Citations: 52     Fields:    Translation:Animals
  64. Song YQ, Cho H, Hopper T, Pomerantz A, Sun PZ. Magnetic resonance in porous media: recent progress. J. Chem. Physics. 2007; accepted.
  65. Sun PZ, Zhou J, Sun W, Huang J, van Zijl PC. Detection of the ischemic penumbra using pH-weighted MRI. J Cereb Blood Flow Metab. 2007 Jun; 27(6):1129-36. PMID: 17133226.
    Citations: 122     Fields:    Translation:Animals
  66. McMahon MT, Gilad AA, Zhou J, Sun PZ, Bulte JW, van Zijl PC. Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): Ph calibration for poly-L-lysine and a starburst dendrimer. Magn Reson Med. 2006 Apr; 55(4):836-47. PMID: 16506187; PMCID: PMC2860536.
    Citations: 108     Fields:    
  67. Sun PZ, Zhou JY, Sun WY, Huang J and van Zijl PC. Delineating the Boundary between the Ischemic Penumbra and Regions of Oligaemia Using pH-weighted MRI (pHWI). Proc. Intl. Soc. Mag. Reson. Med. (14). 2006; 615.
  68. Salhotra A, Sun PZ, van Zijl P, Bhujwalla Z, Lal B, Laterra J and Zhou JY. Blood Flow Increase in Brain Tumor in Response to Radiation Therapy and Chemotherapy as Detected by Arterial Spin Labeling MRI. Proc. Intl. Soc. Mag. Reson. Med. (14). 2006; 1765.
  69. Sun PZ. Accurate Quantification of Diffusion in Heterogeneous Systems Using the New Magic Asymmetric Gradient (MAG) Technique. Proc. Intl. Soc. Mag. Reson. Med. (14). 2006; 1054.
  70. Sun PZ, Zhou JY, Huang J, van Zijl P. Power Optimization of in-vivo Chemical Exchange Saturation Transfer (CEST) contrast for pH weighted Imaging. Proc. Intl. Soc. Mag. Reson. Med. 14. 2006; 105.
  71. Sun PZ, van Zijl PC, Zhou J. Optimization of the irradiation power in chemical exchange dependent saturation transfer experiments. J Magn Reson. 2005 Aug; 175(2):193-200. PMID: 15893487.
    Citations: 55     Fields:    Translation:Cells
  72. Sun PZ, Zhou J, Sun W, Huang J, van Zijl PC. Suppression of lipid artifacts in amide proton transfer imaging. Magn Reson Med. 2005 Jul; 54(1):222-5. PMID: 15968669.
    Citations: 25     Fields:    Translation:Animals
  73. Sun PZ, Zhou JY, Sun WY, Huang J, van Zijl P. Characterization the evolution of ischemic penumbra using pH-weighted imaging. Journal of Cerebral Blood Flow & Metabolism. 2005; 457.
  74. Zhou JY, Salhotra A, Sun PZ, Lal B, van Zijl P, Laterra J. Detecting brain tumor therapy response using amide proton transfer contrast. Proc. Intl. Soc. Mag. Reson. Med. (13). 2005; 243.
  75. Sun PZ, Zhou JY, Sun WY, Huang J, van Zijl P. Characterization the evolution of ischemic penumbra using pH-weighted imaging. Proc. Intl. Soc. Mag. Reson. Med. (13). 2005; 984.
  76. Hua J, Sun PZ, Johns CK, van Zijl PC and Zhou JY. Amide proton transfer imaging contrast in the brain and saturation power optimization. 46th Experimental Nuclear Magnetic Resonance Conference. 2005; 19.
  77. Sun PZ, Zhou JY, Sun WY, Huang J, van Zijl P. Characterization the evolution of ischemic penumbra using pH-weighted imaging. Journal of Cerebral Blood Flow & Metabolism. 2005; 25:457.
  78. Sun PZ, Zhou JY, Sun WY, Huang J, van Zijl P. Lipid artifact suppression in amide proton transfer (APT) EPI imaging. Proc. Intl. Soc. Mag. Reson. Med. (13). 2005; 2212.
  79. Sun PZ, Smith SA, Zhou J. Analysis of the magic asymmetric gradient stimulated echo sequence with shaped gradients. J Magn Reson. 2004 Dec; 171(2):324-9. PMID: 15546759.
    Citations: 1     Fields:    Translation:Cells
  80. Zhou J, Wilson DA, Sun PZ, Klaus JA, Van Zijl PC. Quantitative description of proton exchange processes between water and endogenous and exogenous agents for WEX, CEST, and APT experiments. Magn Reson Med. 2004 May; 51(5):945-52. PMID: 15122676.
    Citations: 91     Fields:    Translation:AnimalsCells
  81. Zhou J, Sun PZ, van Zijl PC. Quantitative Description of Proton Exchange Processes between Water and Endogenous and Exogenous Agents. The sensitivity of PH Imaging using Endogenous Amide Proton Transfer (APT) Contrast. Proc. Intl. Soc. Mag. Reson. Med. (11). 2004; 180.
  82. Hills AJ, Prabhakaran V, Lu HZ, Sun PZ, van Zijl P. fMRI BOLD effect in response to word generation in regions of baseline hypoperfusion (but no infarct) among patients with large vessel arterial stenosis. Scientific Sessions of American Heart Association. 2004.
  83. Prabhakaran V, Raman SP, Grunwald MR, Mahadevia A, Werner JK, Philipose LE, Hussain N, Alphs HH, Sun PZ, Barker PB, Wityk RJ, Rypma B, Hillis AE. Neural Substrates Involved in Conginition for Stroke Patients and Control Subjects. Annual Meeting of Cognitive Neuroscience Society. 2004; 40.
  84. Sun PZ, Seland JG, Cory D. Background gradient suppression in pulsed gradient stimulated echo measurements. J Magn Reson. 2003 Apr; 161(2):168-73. PMID: 12713966.
    Citations: 7     Fields:    Translation:Cells
  85. Sun PZ, Schoening ZB, Jasanoff A. In vivo oxygen detection using exogenous hemoglobin as a contrast agent in magnetic resonance microscopy. Magn Reson Med. 2003 Apr; 49(4):609-14. PMID: 12652529.
    Citations: 6     Fields:    Translation:Animals
  86. Phillip Zhe Sun. NMR diffusion and microscopy. 2003.
  87. Jasanoff A, Sun PZ. In vivo magnetic resonance microscopy of brain structure in unanesthetized flies. J Magn Reson. 2002 Sep-Oct; 158(1-2):79-85. PMID: 12419675.
    Citations: 8     Fields:    Translation:Animals
  88. Sun PZ, Jasanoff A and Cory DG. Q-space imaging and Nuclear Magnetic Resonance microscopy. 43rd Experimental Nuclear Magnetic Resonance Conference. 2002; 202.
  89. Moore A, Sun PZ, Cory D, Högemann D, Weissleder R, Lipes MA. MRI of insulitis in autoimmune diabetes. Magn Reson Med. 2002 Apr; 47(4):751-8. PMID: 11948737.
    Citations: 22     Fields:    Translation:AnimalsCells
  90. Sun PZ, Cory DG. Nuclear Magnetic Resonance (NMR) multiple dimensional diffusive scattering. 42nd Experimental Nuclear Magnetic Resonance Conference. 2001; 230.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.