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Gyongyi Szabo, Ph.D., M.D.

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Overview

Mentoring
Available: 05/29/20, Expires: 01/31/22

The student will evaluate the combined effects of obesity/metabolic syndrome and excess alcohol consumption on innate immune cell interactions and activation pathways with particular focus on inflammasome activation and interferon regulatory factor-3 (IRF3) regulation.

Available: 06/15/20, Expires: 07/31/22

Using novel technologies, the student will test EVs and characterize their cargo in vitro and in vivo in mouse models and human metabolic liver diseases. The functional role of the EV/noncoding RNA content will be further evaluated in inter-cellular communication between liver parenchymal cells and immune cells to unravel novel regulatory circuits in liver injury.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AA017729 (SZABO, GYONGYI) Sep 23, 2019 - Jan 31, 2022
    NIH/NIAAA
    Innate Immune Signaling in Alcoholic Liver Disease
    Role Description: This application further investigates if the absence of TLR4, but not of the MyD88 adaptor, protects mice from alcoholic liver disease.
    Role: Principal Investigator
  2. U01AA026933 (SZABO, GYONGYI) Sep 19, 2019 - Jun 30, 2023
    NIH
    Biomarkers of Disease in Alcoholic Hepatitis
    Role: Principal Investigator
  3. R01AA011576 (SZABO, GYONGYI) Sep 19, 2019 - Mar 31, 2021
    NIH/NIAAA
    Alcohol and Monocyte Signaling
    Role Description: The overall goal of this research is to define molecular mechanisms that regulate the switch from the acute, anti-inflammatory to the chronic, pro-inflammatory effects of alcohol.
    Role: Principal Investigator
  4. UH2AA026970 (SZABO, GYONGYI) Sep 22, 2018 - Jun 30, 2020
    NIH
    Extracellular Vesicles in Alcoholic Liver Disease: Basic and Pre-Clinical Discovery
    Role: Principal Investigator
  5. U01AA026977 (SZABO, GYONGYI) Aug 1, 2018 - Jun 30, 2023
    NIH
    Alcoholic Hepatitis Clinical and Translational Network Late Phase Clinical Trials and Observational Studies 4/9
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Engelmann C, Clària J, Szabo G, Bosch J, Bernardi M. Pathophysiology of decompensated cirrhosis: Portal hypertension, circulatory dysfunction, inflammation, metabolism and mitochondrial dysfunction. J Hepatol. 2021 Jul; 75 Suppl 1:S49-S66. PMID: 34039492.
    Citations:    Fields:    
  2. Jalan R, Szabo G. New concepts and perspectives in decompensated cirrhosis. J Hepatol. 2021 Jul; 75 Suppl 1:S1-S2. PMID: 34039481.
    Citations:    Fields:    
  3. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Biermann J, Bloom-Ackermann Z, Barkas N, Ganna A, Gomez J, Melms JC, Katsyv I, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Wang Y, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jané-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hibshoosh H, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Ellinor PT, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Jiang ZG, Juric D, Babadi M, Farhi SL, Izar B, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. 2021 Apr 29. PMID: 33915569.
    Citations:    Fields:    
  4. Szabo G. Exosomes and MicroRNA-223 at the Intersection of Inflammation and Fibrosis in NAFLD. Hepatology. 2021 Mar 16. PMID: 33724502.
    Citations:    Fields:    
  5. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe A, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Bloom-Ackerman Z, Barkas N, Ganna A, Gomez J, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jane-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Gordon Jiang Z, Juric D, Babadi M, Farhi SL, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2. bioRxiv. 2021 Feb 25. PMID: 33655247.
    Citations:    
  6. Miyata T, Wu X, Fan X, Huang E, Sanz-Garcia C, Ross CKC, Roychowdhury S, Bellar A, McMullen MR, Dasarathy J, Allende DS, Caballeria J, Sancho-Bru P, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Nagy LE. Differential role of MLKL in alcohol-associated and non-alcohol-associated fatty liver diseases in mice and humans. JCI Insight. 2021 Feb 22; 6(4). PMID: 33616081.
    Citations:    Fields:    
  7. Cho Y, Szabo G. Two faces of neutrophils in liver disease development and progression. Hepatology. 2020 Dec 13. PMID: 33314193.
    Citations: 1     Fields:    
  8. Fan X, McCullough RL, Huang E, Bellar A, Kim A, Poulsen KL, McClain CJ, Mitchell M, McCullough AJ, Radaeva S, Barton B, Szabo G, Dasarathy S, Rotroff DM, Nagy LE. Diagnostic and Prognostic Significance of Complement in Patients With Alcohol-Associated Hepatitis. Hepatology. 2021 Mar; 73(3):983-997. PMID: 32557728.
    Citations: 2     Fields:    
  9. He Y, Hwang S, Ahmed YA, Feng D, Li N, Ribeiro M, Lafdil F, Kisseleva T, Szabo G, Gao B. Immunopathobiology and therapeutic targets related to cytokines in liver diseases. Cell Mol Immunol. 2021 Jan; 18(1):18-37. PMID: 33203939.
    Citations: 2     Fields:    
  10. Francque S, Szabo G, Abdelmalek MF, Byrne CD, Cusi K, Dufour JF, Roden M, Sacks F, Tacke F. Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors. Nat Rev Gastroenterol Hepatol. 2021 01; 18(1):24-39. PMID: 33093663.
    Citations: 3     Fields:    Translation:Humans
  11. Monnig MA, Lamb PS, Parra JM, Cioe PA, Martone CM, Monti PM, Szabo G. Immune Response to an Acute Moderate Dose of Alcohol in Healthy Young Adults. Alcohol Alcohol. 2020 Oct 20; 55(6):616-623. PMID: 32776108.
    Citations:    Fields:    
  12. Im GY, Mellinger JL, Winters A, Aby ES, Lominadze Z, Rice J, Lucey MR, Arab JP, Goel A, Jophlin LL, Sherman CB, Parker R, Chen PH, Devuni D, Sidhu S, Dunn W, Szabo G, Singal AK, Shah VH. Provider Attitudes and Practices for Alcohol Screening, Treatment, and Education in Patients With Liver Disease: A Survey From the American Association for the Study of Liver Diseases Alcohol-Associated Liver Disease Special Interest Group. Clin Gastroenterol Hepatol. 2020 Oct 16. PMID: 33069880.
    Citations:    Fields:    
  13. Lowe PP, Morel C, Ambade A, Iracheta-Vellve A, Kwiatkowski E, Satishchandran A, Furi I, Cho Y, Gyongyosi B, Catalano D, Lefebvre E, Fischer L, Seyedkazemi S, Schafer DP, Szabo G. Chronic alcohol-induced neuroinflammation involves CCR2/5-dependent peripheral macrophage infiltration and microglia alterations. J Neuroinflammation. 2020 Oct 09; 17(1):296. PMID: 33036616.
    Citations:    Fields:    
  14. Tornai D, Szabo G. Emerging medical therapies for severe alcoholic hepatitis. Clin Mol Hepatol. 2020 10; 26(4):686-696. PMID: 32981291.
    Citations: 1     Fields:    
  15. Bala S, Calenda CD, Catalano D, Babuta M, Kodys K, Nasser IA, Vidal B, Szabo G. Deficiency of miR-208a Exacerbates CCl4-Induced Acute Liver Injury in Mice by Activating Cell Death Pathways. Hepatol Commun. 2020 Oct; 4(10):1487-1501. PMID: 33024918.
    Citations:    
  16. Dasarathy S, Mitchell MC, Barton B, McClain CJ, Szabo G, Nagy LE, Radaeva S, McCullough AJ. Design and rationale of a multicenter defeat alcoholic steatohepatitis trial: (DASH) randomized clinical trial to treat alcohol-associated hepatitis. Contemp Clin Trials. 2020 09; 96:106094. PMID: 32739495.
    Citations: 3     Fields:    
  17. Osna NA, Bhatia R, Thompson C, Batra SK, Kumar S, Cho Y, Szabo G, Molina PE, Weinman SA, Ganesan M, Kharbanda KK. Role of non-Genetic Risk Factors in Exacerbating Alcohol-related organ damage. Alcohol. 2020 09; 87:63-72. PMID: 32497558.
    Citations:    Fields:    
  18. Al-Azzawi Y, Albo B, Fasullo M, Coukos J, Watts GJ, Tai R, Radcliffe D, Kroll-Desrosiers A, Devuni D, Szabo G. Sarcopenia is associated with longer hospital stay and multiorgan dysfunction in alcoholic hepatitis. Eur J Gastroenterol Hepatol. 2020 06; 32(6):733-738. PMID: 31834050.
    Citations: 1     Fields:    
  19. Lowe PP, Cho Y, Tornai D, Coban S, Catalano D, Szabo G. Inhibition of the Inflammasome Signaling Cascade Reduces Alcohol Consumption in Female But Not Male Mice. Alcohol Clin Exp Res. 2020 02; 44(2):567-578. PMID: 31854009.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Crabb DW, Im GY, Szabo G, Mellinger JL, Lucey MR. Diagnosis and Treatment of Alcohol-Associated Liver Diseases: 2019 Practice Guidance From the American Association for the Study of Liver Diseases. Hepatology. 2020 01; 71(1):306-333. PMID: 31314133.
    Citations: 43     Fields:    Translation:Humans
  21. Avila MA, Dufour JF, Gerbes AL, Zoulim F, Bataller R, Burra P, Cortez-Pinto H, Gao B, Gilmore I, Mathurin P, Moreno C, Poznyak V, Schnabl B, Szabo G, Thiele M, Thursz MR. Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting. Gut. 2020 04; 69(4):764-780. PMID: 31879281.
    Citations: 11     Fields:    Translation:Humans
  22. Szabo G. Pathogenesis of Acute-on-Chronic Liver Failure in Patients With Infection. Clin Liver Dis (Hoboken). 2019 Sep; 14(3):103-106. PMID: 31632659.
    Citations:    
  23. Lucey MR, Im GY, Mellinger JL, Szabo G, Crabb DW. Introducing the 2019 American Association for the Study of Liver Diseases Guidance on Alcohol-Associated Liver Disease. Liver Transpl. 2020 01; 26(1):14-16. PMID: 31299131.
    Citations: 3     Fields:    Translation:Humans
  24. Hosseini N, Shor J, Szabo G. Alcoholic Hepatitis: A Review. Alcohol Alcohol. 2019 Jul 01; 54(4):408-416. PMID: 31219169.
    Citations: 7     Fields:    Translation:HumansCells
  25. Fasullo M, Rau P, Liu DQ, Holzwanger E, Mathew JP, Guilarte-Walker Y, Szabo G. Proton pump inhibitors increase the severity of hepatic encephalopathy in cirrhotic patients. World J Hepatol. 2019 Jun 27; 11(6):522-530. PMID: 31293720.
    Citations: 4     
  26. Babuta M, Furi I, Bala S, Bukong TN, Lowe P, Catalano D, Calenda C, Kodys K, Szabo G. Dysregulated Autophagy and Lysosome Function Are Linked to Exosome Production by Micro-RNA 155 in Alcoholic Liver Disease. Hepatology. 2019 12; 70(6):2123-2141. PMID: 31090940.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  27. Saha B, Tornai D, Kodys K, Adejumo A, Lowe P, McClain C, Mitchell M, McCullough A, Dasarathy S, Kroll-Desrosiers A, Barton B, Radaeva S, Szabo G. Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis. Hepatology. 2019 10; 70(4):1134-1149. PMID: 30891779.
    Citations: 15     Fields:    Translation:Humans
  28. Al-Azzawi Y, Rouanet E, Hendrix RJ, Spaho L, Malik H, Devuni D, Szabo G, Barnard G. Segmental Distribution of Hepatocellular Carcinoma Correlates with Microvascular Invasion in Liver Explants Undergoing Transplantation. J Cancer Epidemiol. 2019; 2019:8534372. PMID: 31186641.
    Citations: 1     
  29. Ambade A, Lowe P, Kodys K, Catalano D, Gyongyosi B, Cho Y, Iracheta-Vellve A, Adejumo A, Saha B, Calenda C, Mehta J, Lefebvre E, Vig P, Szabo G. Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice. Hepatology. 2019 03; 69(3):1105-1121. PMID: 30179264.
    Citations: 24     Fields:    Translation:AnimalsCells
  30. Moreno C, Mueller S, Szabo G. Non-invasive diagnosis and biomarkers in alcohol-related liver disease. J Hepatol. 2019 02; 70(2):273-283. PMID: 30658728.
    Citations: 19     Fields:    Translation:HumansAnimals
  31. Thursz M, Kamath PS, Mathurin P, Szabo G, Shah VH. Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study. J Hepatol. 2019 03; 70(3):521-530. PMID: 30658117.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  32. Szabo G, Kamath PS, Shah VH, Thursz M, Mathurin P. Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study. Hepatology. 2019 05; 69(5):2271-2283. PMID: 30645002.
    Citations: 21     Fields:    Translation:Humans
  33. Wang X, de Carvalho Ribeiro M, Iracheta-Vellve A, Lowe P, Ambade A, Satishchandran A, Bukong T, Catalano D, Kodys K, Szabo G. Macrophage-Specific Hypoxia-Inducible Factor-1a Contributes to Impaired Autophagic Flux in Nonalcoholic Steatohepatitis. Hepatology. 2019 02; 69(2):545-563. PMID: 30102772.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Banales JM, Feldstein AE, Sänger H, Lukacs-Kornek V, Szabo G, Kornek M. Extracellular Vesicles in Liver Diseases: Meeting Report from the International Liver Congress 2018. Hepatol Commun. 2019 Feb; 3(2):305-315. PMID: 30766966.
    Citations: 7     
  35. Tornai D, Furi I, Shen ZT, Sigalov AB, Coban S, Szabo G. Inhibition of Triggering Receptor Expressed on Myeloid Cells 1 Ameliorates Inflammation and Macrophage and Neutrophil Activation in Alcoholic Liver Disease in Mice. Hepatol Commun. 2019 Jan; 3(1):99-115. PMID: 30619998.
    Citations: 11     
  36. Lowe PP, Gyongyosi B, Satishchandran A, Iracheta-Vellve A, Cho Y, Ambade A, Szabo G. Reduced gut microbiome protects from alcohol-induced neuroinflammation and alters intestinal and brain inflammasome expression. J Neuroinflammation. 2018 Oct 27; 15(1):298. PMID: 30368255.
    Citations: 15     Fields:    Translation:Animals
  37. Iracheta-Vellve A, Calenda CD, Petrasek J, Ambade A, Kodys K, Adorini L, Szabo G. FXR and TGR5 Agonists Ameliorate Liver Injury, Steatosis, and Inflammation After Binge or Prolonged Alcohol Feeding in Mice. Hepatol Commun. 2018 Nov; 2(11):1379-1391. PMID: 30411084.
    Citations: 16     
  38. Bala S, Szabo G. TFEB, a master regulator of lysosome biogenesis and autophagy, is a new player in alcoholic liver disease. Dig Med Res. 2018 Sep; 1. PMID: 30450489.
    Citations: 5     
  39. Bajaj JS, Moreau R, Kamath PS, Vargas HE, Arroyo V, Reddy KR, Szabo G, Tandon P, Olson J, Karvellas C, Gustot T, Lai JC, Wong F. Acute-on-Chronic Liver Failure: Getting Ready for Prime Time? Hepatology. 2018 10; 68(4):1621-1632. PMID: 29689120.
    Citations: 18     Fields:    Translation:Humans
  40. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. Publisher Correction: Alcoholic liver disease. Nat Rev Dis Primers. 2018 08 28; 4(1):18. PMID: 30154473.
    Citations: 3     Fields:    
  41. Seitz HK, Bataller R, Cortez-Pinto H, Gao B, Gual A, Lackner C, Mathurin P, Mueller S, Szabo G, Tsukamoto H. Alcoholic liver disease. Nat Rev Dis Primers. 2018 08 16; 4(1):16. PMID: 30115921.
    Citations: 79     Fields:    Translation:Humans
  42. Bukong TN, Cho Y, Iracheta-Vellve A, Saha B, Lowe P, Adejumo A, Furi I, Ambade A, Gyongyosi B, Catalano D, Kodys K, Szabo G. Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use. J Hepatol. 2018 Nov; 69(5):1145-1154. PMID: 30030149.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  43. Szabo G. Gut-Liver Axis Beyond the Microbiome: How the Fungal Mycobiome Contributes to Alcoholic Liver Disease. Hepatology. 2018 12; 68(6):2426-2428. PMID: 29684245.
    Citations: 3     Fields:    Translation:HumansAnimals
  44. Szabo G. More than meets the eye: Severe alcoholic hepatitis can present as acute-on-chronic liver failure. J Hepatol. 2018 08; 69(2):269-271. PMID: 29935965.
    Citations: 2     Fields:    Translation:Humans
  45. Pilli VS, Datta A, Afreen S, Catalano D, Szabo G, Majumder R. Hypoxia downregulates protein S expression. Blood. 2018 07 26; 132(4):452-455. PMID: 29784640.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  46. Satishchandran A, Szabo G. Reply. Gastroenterology. 2018 06; 154(8):2277-2278. PMID: 29750907.
    Citations:    Fields:    
  47. Saha B, Momen-Heravi F, Furi I, Kodys K, Catalano D, Gangopadhyay A, Haraszti R, Satishchandran A, Iracheta-Vellve A, Adejumo A, Shaffer SA, Szabo G. Extracellular vesicles from mice with alcoholic liver disease carry a distinct protein cargo and induce macrophage activation through heat shock protein 90. Hepatology. 2018 05; 67(5):1986-2000. PMID: 29251792.
    Citations: 38     Fields:    Translation:AnimalsCells
  48. Szabo G. Women and alcoholic liver disease - warning of a silent danger. Nat Rev Gastroenterol Hepatol. 2018 05; 15(5):253-254. PMID: 29443115.
    Citations: 6     Fields:    Translation:Humans
  49. Szabo G, Brink E. Hepatology Communications: Now in pubmed central and applying for other indices. Hepatol Commun. 2018 02; 2(2):125-127. PMID: 29404518.
    Citations:    
  50. Szabo G. Alcoholic Liver Disease Accelerates Early Hepatocellular Cancer in a Mouse Model. Adv Exp Med Biol. 2018; 1032:71-79. PMID: 30362091.
    Citations: 1     Fields:    Translation:Animals
  51. Szabo G. Clinical Trial Design for Alcoholic Hepatitis. Semin Liver Dis. 2017 11; 37(4):332-342. PMID: 29272895.
    Citations: 6     Fields:    Translation:Humans
  52. Iracheta-Vellve A, Szabo G. IL-1a in acetaminophen toxicity: a sterile danger signal. Cell Mol Immunol. 2018 Mar; 15(3):284-285. PMID: 29151582.
    Citations: 1     Fields:    Translation:AnimalsCells
  53. Satishchandran A, Ambade A, Rao S, Hsueh YC, Iracheta-Vellve A, Tornai D, Lowe P, Gyongyosi B, Li J, Catalano D, Zhong L, Kodys K, Xie J, Bala S, Gao G, Szabo G. MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease. Gastroenterology. 2018 01; 154(1):238-252.e7. PMID: 28987423.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  54. Szabo G, Petrasek J. Gut-liver axis and sterile signals in the development of alcoholic liver disease. Alcohol Alcohol. 2017 Jul 01; 52(4):414-424. PMID: 28482064.
    Citations: 10     Fields:    Translation:Humans
  55. Gustot T, Fernandez J, Szabo G, Albillos A, Louvet A, Jalan R, Moreau R, Moreno C. Sepsis in alcohol-related liver disease. J Hepatol. 2017 11; 67(5):1031-1050. PMID: 28647569.
    Citations: 18     Fields:    Translation:Humans
  56. Szabo G, Momen-Heravi F. Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets. Nat Rev Gastroenterol Hepatol. 2017 Aug; 14(8):455-466. PMID: 28634412.
    Citations: 57     Fields:    Translation:HumansCells
  57. Bala S, Csak T, Kodys K, Catalano D, Ambade A, Furi I, Lowe P, Cho Y, Iracheta-Vellve A, Szabo G. Alcohol-induced miR-155 and HDAC11 inhibit negative regulators of the TLR4 pathway and lead to increased LPS responsiveness of Kupffer cells in alcoholic liver disease. J Leukoc Biol. 2017 08; 102(2):487-498. PMID: 28584078.
    Citations: 19     Fields:    Translation:AnimalsCells
  58. Furi I, Momen-Heravi F, Szabo G. Extracellular vesicle isolation: present and future. Ann Transl Med. 2017 Jun; 5(12):263. PMID: 28706931.
    Citations: 18     
  59. Grander C, Adolph TE, Wieser V, Lowe P, Wrzosek L, Gyongyosi B, Ward DV, Grabherr F, Gerner RR, Pfister A, Enrich B, Ciocan D, Macheiner S, Mayr L, Drach M, Moser P, Moschen AR, Perlemuter G, Szabo G, Cassard AM, Tilg H. Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease. Gut. 2018 05; 67(5):891-901. PMID: 28550049.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  60. Iracheta-Vellve A, Petrasek J, Gyogyosi B, Bala S, Csak T, Kodys K, Szabo G. Interleukin-1 inhibition facilitates recovery from liver injury and promotes regeneration of hepatocytes in alcoholic hepatitis in mice. Liver Int. 2017 07; 37(7):968-973. PMID: 28345165.
    Citations: 9     Fields:    Translation:AnimalsCells
  61. Lowe PP, Gyongyosi B, Satishchandran A, Iracheta-Vellve A, Ambade A, Kodys K, Catalano D, Ward DV, Szabo G. Alcohol-related changes in the intestinal microbiome influence neutrophil infiltration, inflammation and steatosis in early alcoholic hepatitis in mice. PLoS One. 2017; 12(3):e0174544. PMID: 28350851.
    Citations: 26     Fields:    Translation:AnimalsCells
  62. Szabo G. Introducing Hepatology Communications. Hepatol Commun. 2017 Feb; 1(1):5-6. PMID: 29404428.
    Citations:    
  63. Saha B, Kodys K, Adejumo A, Szabo G. Circulating and Exosome-Packaged Hepatitis C Single-Stranded RNA Induce Monocyte Differentiation via TLR7/8 to Polarized Macrophages and Fibrocytes. J Immunol. 2017 03 01; 198(5):1974-1984. PMID: 28122964.
    Citations: 13     Fields:    Translation:HumansCells
  64. Iracheta-Vellve A, Petrasek J, Gyongyosi B, Satishchandran A, Lowe P, Kodys K, Catalano D, Calenda CD, Kurt-Jones EA, Fitzgerald KA, Szabo G. Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes. J Biol Chem. 2016 Dec 23; 291(52):26794-26805. PMID: 27810900.
    Citations: 27     Fields:    Translation:AnimalsCells
  65. Ambade A, Satishchandran A, Saha B, Gyongyosi B, Lowe P, Kodys K, Catalano D, Szabo G. Hepatocellular carcinoma is accelerated by NASH involving M2 macrophage polarization mediated by hif-1ainduced IL-10. Oncoimmunology. 2016; 5(10):e1221557. PMID: 27853646.
    Citations: 26     
  66. Bukong TN, Iracheta-Vellve A, Saha B, Ambade A, Satishchandran A, Gyongyosi B, Lowe P, Catalano D, Kodys K, Szabo G. Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease. Hepatology. 2016 10; 64(4):1057-71. PMID: 27302565.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  67. Bukong TN, Iracheta-Vellve A, Gyongyosi B, Ambade A, Catalano D, Kodys K, Szabo G. Therapeutic Benefits of Spleen Tyrosine Kinase Inhibitor Administration on Binge Drinking-Induced Alcoholic Liver Injury, Steatosis, and Inflammation in Mice. Alcohol Clin Exp Res. 2016 07; 40(7):1524-30. PMID: 27177528.
    Citations: 11     Fields:    Translation:Animals
  68. Ambade A, Satishchandran A, Gyongyosi B, Lowe P, Szabo G. Adult mouse model of early hepatocellular carcinoma promoted by alcoholic liver disease. World J Gastroenterol. 2016 Apr 28; 22(16):4091-108. PMID: 27122661.
    Citations: 14     Fields:    Translation:AnimalsCells
  69. Tilg H, Moschen AR, Szabo G. Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. Hepatology. 2016 09; 64(3):955-65. PMID: 26773297.
    Citations: 60     Fields:    Translation:HumansAnimals
  70. Crabb DW, Bataller R, Chalasani NP, Kamath PS, Lucey M, Mathurin P, McClain C, McCullough A, Mitchell MC, Morgan TR, Nagy L, Radaeva S, Sanyal A, Shah V, Szabo G. Standard Definitions and Common Data Elements for Clinical Trials in Patients With Alcoholic Hepatitis: Recommendation From the NIAAA Alcoholic Hepatitis Consortia. Gastroenterology. 2016 Apr; 150(4):785-90. PMID: 26921783.
    Citations: 80     Fields:    Translation:Humans
  71. Ambade A, Satishchandran A, Szabo G. Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR-122-mediated HIF-1a activation. Sci Rep. 2016 Feb 18; 6:21340. PMID: 26888602.
    Citations: 22     Fields:    Translation:AnimalsCells
  72. Bala S, Csak T, Saha B, Zatsiorsky J, Kodys K, Catalano D, Satishchandran A, Szabo G. The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis. J Hepatol. 2016 06; 64(6):1378-87. PMID: 26867493.
    Citations: 57     Fields:    Translation:AnimalsCells
  73. Szabo G, Csak T. Role of MicroRNAs in NAFLD/NASH. Dig Dis Sci. 2016 May; 61(5):1314-24. PMID: 26769057.
    Citations: 18     Fields:    Translation:Humans
  74. Saha B, Kodys K, Szabo G. Hepatitis C Virus-Induced Monocyte Differentiation Into Polarized M2 Macrophages Promotes Stellate Cell Activation via TGF-ß. Cell Mol Gastroenterol Hepatol. 2016 May; 2(3):302-316.e8. PMID: 28090562.
    Citations: 18     Fields:    
  75. Saha B, Momen-Heravi F, Kodys K, Szabo G. MicroRNA Cargo of Extracellular Vesicles from Alcohol-exposed Monocytes Signals Naive Monocytes to Differentiate into M2 Macrophages. J Biol Chem. 2016 Jan 01; 291(1):149-59. PMID: 26527689.
    Citations: 60     Fields:    Translation:HumansCells
  76. Momen-Heravi F, Saha B, Kodys K, Catalano D, Satishchandran A, Szabo G. Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis. J Transl Med. 2015 Aug 12; 13:261. PMID: 26264599.
    Citations: 81     Fields:    Translation:HumansAnimalsCells
  77. Szabo G, Iracheta-Vellve A. Inflammasome activation in the liver: Focus on alcoholic and non-alcoholic steatohepatitis. Clin Res Hepatol Gastroenterol. 2015 Sep; 39 Suppl 1:S18-23. PMID: 26216030.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  78. Iracheta-Vellve A, Petrasek J, Satishchandran A, Gyongyosi B, Saha B, Kodys K, Fitzgerald KA, Kurt-Jones EA, Szabo G. Inhibition of sterile danger signals, uric acid and ATP, prevents inflammasome activation and protects from alcoholic steatohepatitis in mice. J Hepatol. 2015 Nov; 63(5):1147-55. PMID: 26100496.
    Citations: 39     Fields:    Translation:AnimalsCells
  79. Ganz M, Bukong TN, Csak T, Saha B, Park JK, Ambade A, Kodys K, Szabo G. Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice. J Transl Med. 2015 Jun 16; 13:193. PMID: 26077675.
    Citations: 34     Fields:    Translation:AnimalsCells
  80. Szabo G, Petrasek J. Inflammasome activation and function in liver disease. Nat Rev Gastroenterol Hepatol. 2015 Jul; 12(7):387-400. PMID: 26055245.
    Citations: 136     Fields:    Translation:HumansAnimals
  81. Csak T, Bala S, Lippai D, Kodys K, Catalano D, Iracheta-Vellve A, Szabo G. MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis. PLoS One. 2015; 10(6):e0129251. PMID: 26042593.
    Citations: 26     Fields:    Translation:AnimalsCells
  82. Bala S, Csak T, Momen-Heravi F, Lippai D, Kodys K, Catalano D, Satishchandran A, Ambros V, Szabo G. Biodistribution and function of extracellular miRNA-155 in mice. Sci Rep. 2015 May 29; 5:10721. PMID: 26024046.
    Citations: 40     Fields:    Translation:AnimalsCells
  83. Sanyal AJ, Gao B, Szabo G. Gaps in Knowledge and Research Priorities for Alcoholic Hepatitis. Gastroenterology. 2015 Jul; 149(1):4-9. PMID: 26008859.
    Citations: 8     Fields:    Translation:Humans
  84. Momen-Heravi F, Bala S, Kodys K, Szabo G. Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS. Sci Rep. 2015 May 14; 5:9991. PMID: 25973575.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  85. Petrasek J, Iracheta-Vellve A, Saha B, Satishchandran A, Kodys K, Fitzgerald KA, Kurt-Jones EA, Szabo G. Metabolic danger signals, uric acid and ATP, mediate inflammatory cross-talk between hepatocytes and immune cells in alcoholic liver disease. J Leukoc Biol. 2015 Aug; 98(2):249-56. PMID: 25934928.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  86. Saha B, Bala S, Hosseini N, Kodys K, Szabo G. Krüppel-like factor 4 is a transcriptional regulator of M1/M2 macrophage polarization in alcoholic liver disease. J Leukoc Biol. 2015 May; 97(5):963-973. PMID: 25740962.
    Citations: 11     Fields:    
  87. Saha B, Bruneau JC, Kodys K, Szabo G. Alcohol-induced miR-27a regulates differentiation and M2 macrophage polarization of normal human monocytes. J Immunol. 2015 Apr 01; 194(7):3079-87. PMID: 25716995.
    Citations: 32     Fields:    Translation:HumansCells
  88. Szabo G, Satishchandran A. MicroRNAs in alcoholic liver disease. Semin Liver Dis. 2015 Feb; 35(1):36-42. PMID: 25632933.
    Citations: 20     Fields:    Translation:HumansCells
  89. Szabo G, Saha B. Alcohol's Effect on Host Defense. Alcohol Res. 2015; 37(2):159-70. PMID: 26695755.
    Citations: 70     Fields:    Translation:Humans
  90. Szabo G, Saha B, Bukong TN. Alcohol and HCV: implications for liver cancer. Adv Exp Med Biol. 2015; 815:197-216. PMID: 25427909.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  91. Kolls JK, Szabo G. The genetics of hepatitis C virus underlie its ability to escape humoral immunity. J Clin Invest. 2015 Jan; 125(1):97-8. PMID: 25500881.
    Citations: 4     Fields:    Translation:HumansCells
  92. Szabo G. Gut-liver axis in alcoholic liver disease. Gastroenterology. 2015 Jan; 148(1):30-6. PMID: 25447847.
    Citations: 166     Fields:    Translation:HumansAnimalsCells
  93. Bukong TN, Momen-Heravi F, Kodys K, Bala S, Szabo G. Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90. PLoS Pathog. 2014 Oct; 10(10):e1004424. PMID: 25275643.
    Citations: 139     Fields:    Translation:HumansCells
  94. Bukong TN, Kodys K, Szabo G. A Novel Human Radixin Peptide Inhibits Hepatitis C Virus Infection at the Level of Cell Entry. Int J Pept Res Ther. 2014 Sep; 20(3):269-276. PMID: 25379035.
    Citations: 1     
  95. Lippai D, Bala S, Catalano D, Kodys K, Szabo G. Micro-RNA-155 deficiency prevents alcohol-induced serum endotoxin increase and small bowel inflammation in mice. Alcohol Clin Exp Res. 2014 Aug; 38(8):2217-24. PMID: 25156614.
    Citations: 35     Fields:    Translation:Animals
  96. Csak T, Bala S, Lippai D, Satishchandran A, Catalano D, Kodys K, Szabo G. microRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis. Liver Int. 2015 Feb; 35(2):532-41. PMID: 25040043.
    Citations: 41     Fields:    Translation:AnimalsCells
  97. Ganz M, Csak T, Szabo G. High fat diet feeding results in gender specific steatohepatitis and inflammasome activation. World J Gastroenterol. 2014 Jul 14; 20(26):8525-34. PMID: 25024607.
    Citations: 36     Fields:    Translation:Animals
  98. Saha B, Szabo G. Innate immune cell networking in hepatitis C virus infection. J Leukoc Biol. 2014 Nov; 96(5):757-66. PMID: 25001860.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  99. Bala S, Marcos M, Gattu A, Catalano D, Szabo G. Acute binge drinking increases serum endotoxin and bacterial DNA levels in healthy individuals. PLoS One. 2014; 9(5):e96864. PMID: 24828436.
    Citations: 101     Fields:    Translation:Humans
  100. Csak T, Pillai A, Ganz M, Lippai D, Petrasek J, Park JK, Kodys K, Dolganiuc A, Kurt-Jones EA, Szabo G. Both bone marrow-derived and non-bone marrow-derived cells contribute to AIM2 and NLRP3 inflammasome activation in a MyD88-dependent manner in dietary steatohepatitis. Liver Int. 2014 Oct; 34(9):1402-13. PMID: 24650018.
    Citations: 23     Fields:    Translation:AnimalsCells
  101. Momen-Heravi F, Bala S, Bukong T, Szabo G. Exosome-mediated delivery of functionally active miRNA-155 inhibitor to macrophages. Nanomedicine. 2014 Oct; 10(7):1517-27. PMID: 24685946.
    Citations: 66     Fields:    Translation:AnimalsCells
  102. Szabo G, Lippai D. Converging actions of alcohol on liver and brain immune signaling. Int Rev Neurobiol. 2014; 118:359-80. PMID: 25175869.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  103. Petrasek J, Iracheta-Vellve A, Csak T, Satishchandran A, Kodys K, Kurt-Jones EA, Fitzgerald KA, Szabo G. STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16544-9. PMID: 24052526.
    Citations: 113     Fields:    Translation:AnimalsCells
  104. Bukong TN, Kodys K, Szabo G. Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection. Hepatology. 2013 Nov; 58(5):1569-79. PMID: 23703860.
    Citations: 12     Fields:    Translation:HumansCells
  105. Ganz M, Szabo G. Immune and inflammatory pathways in NASH. Hepatol Int. 2013 Dec; 7 Suppl 2:771-81. PMID: 24587847.
    Citations: 60     Fields:    
  106. Lippai D, Bala S, Csak T, Kurt-Jones EA, Szabo G. Chronic alcohol-induced microRNA-155 contributes to neuroinflammation in a TLR4-dependent manner in mice. PLoS One. 2013; 8(8):e70945. PMID: 23951048.
    Citations: 54     Fields:    Translation:AnimalsCells
  107. Petrasek J, Csak T, Ganz M, Szabo G. Differences in innate immune signaling between alcoholic and non-alcoholic steatohepatitis. J Gastroenterol Hepatol. 2013 Aug; 28 Suppl 1:93-8. PMID: 23855302.
    Citations: 13     Fields:    Translation:HumansCells
  108. Cabrera R, Szabo G. Another armed CD4(+) T cell ready to battle hepatocellular carcinoma. Hepatology. 2013 Jul; 58(1):1-3. PMID: 23475554.
    Citations: 4     Fields:    Translation:HumansCells
  109. Szabo G, Bala S. Reply: To PMID 22684891. Hepatology. 2013 Jun; 57(6):2547. PMID: 23112144.
    Citations: 2     Fields:    Translation:AnimalsCells
  110. Szabo G, Bala S. MicroRNAs in liver disease. Nat Rev Gastroenterol Hepatol. 2013 Sep; 10(9):542-52. PMID: 23689081.
    Citations: 211     Fields:    Translation:Humans
  111. Zhang S, Saha B, Kodys K, Szabo G. IFN-? production by human natural killer cells in response to HCV-infected hepatoma cells is dependent on accessory cells. J Hepatol. 2013 Sep; 59(3):442-9. PMID: 23665181.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  112. Lippai D, Bala S, Petrasek J, Csak T, Levin I, Kurt-Jones EA, Szabo G. Alcohol-induced IL-1ß in the brain is mediated by NLRP3/ASC inflammasome activation that amplifies neuroinflammation. J Leukoc Biol. 2013 Jul; 94(1):171-82. PMID: 23625200.
    Citations: 79     Fields:    Translation:AnimalsCells
  113. Shukla SD, Pruett SB, Szabo G, Arteel GE. Binge ethanol and liver: new molecular developments. Alcohol Clin Exp Res. 2013 Apr; 37(4):550-7. PMID: 23347137.
    Citations: 27     Fields:    Translation:HumansAnimals
  114. Zhang S, Kodys K, Babcock GJ, Szabo G. CD81/CD9 tetraspanins aid plasmacytoid dendritic cells in recognition of hepatitis C virus-infected cells and induction of interferon-alpha. Hepatology. 2013 Sep; 58(3):940-9. PMID: 22577054.
    Citations: 21     Fields:    Translation:HumansCells
  115. Bukong TN, Hou W, Kodys K, Szabo G. Ethanol facilitates hepatitis C virus replication via up-regulation of GW182 and heat shock protein 90 in human hepatoma cells. Hepatology. 2013 Jan; 57(1):70-80. PMID: 22898980.
    Citations: 19     Fields:    Translation:HumansCells
  116. Petrasek J, Csak T, Szabo G. Toll-like receptors in liver disease. Adv Clin Chem. 2013; 59:155-201. PMID: 23461136.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  117. Hou W, Bukong TN, Kodys K, Szabo G. Alcohol facilitates HCV RNA replication via up-regulation of miR-122 expression and inhibition of cyclin G1 in human hepatoma cells. Alcohol Clin Exp Res. 2013 Apr; 37(4):599-608. PMID: 23126531.
    Citations: 18     Fields:    Translation:HumansCells
  118. Zhang S, Kodys K, Li K, Szabo G. Human type 2 myeloid dendritic cells produce interferon-? and amplify interferon-a in response to hepatitis C virus infection. Gastroenterology. 2013 Feb; 144(2):414-425.e7. PMID: 23089201.
    Citations: 50     Fields:    Translation:HumansCells
  119. Szabo G, Petrasek J, Bala S. Innate immunity and alcoholic liver disease. Dig Dis. 2012; 30 Suppl 1:55-60. PMID: 23075869.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  120. Dolganiuc A, Kodys K, Marshall C, Saha B, Zhang S, Bala S, Szabo G. Type III interferons, IL-28 and IL-29, are increased in chronic HCV infection and induce myeloid dendritic cell-mediated FoxP3+ regulatory T cells. PLoS One. 2012; 7(10):e44915. PMID: 23071503.
    Citations: 25     Fields:    Translation:HumansCells
  121. Petrasek J, Bala S, Csak T, Lippai D, Kodys K, Menashy V, Barrieau M, Min SY, Kurt-Jones EA, Szabo G. IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice. J Clin Invest. 2012 Oct; 122(10):3476-89. PMID: 22945633.
    Citations: 228     Fields:    Translation:AnimalsCells
  122. Morin TJ, Broering TJ, Leav BA, Blair BM, Rowley KJ, Boucher EN, Wang Y, Cheslock PS, Knauber M, Olsen DB, Ludmerer SW, Szabo G, Finberg RW, Purcell RH, Lanford RE, Ambrosino DM, Molrine DC, Babcock GJ. Human monoclonal antibody HCV1 effectively prevents and treats HCV infection in chimpanzees. PLoS Pathog. 2012; 8(8):e1002895. PMID: 22952447.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  123. Bala S, Tilahun Y, Taha O, Alao H, Kodys K, Catalano D, Szabo G. Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection. J Transl Med. 2012 Jul 30; 10:151. PMID: 22846613.
    Citations: 53     Fields:    Translation:HumansCells
  124. Bala S, Petrasek J, Mundkur S, Catalano D, Levin I, Ward J, Alao H, Kodys K, Szabo G. Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug-induced, and inflammatory liver diseases. Hepatology. 2012 Nov; 56(5):1946-57. PMID: 22684891.
    Citations: 234     Fields:    Translation:AnimalsCells
  125. Bala S, Tang A, Catalano D, Petrasek J, Taha O, Kodys K, Szabo G. Induction of Bcl-3 by acute binge alcohol results in toll-like receptor 4/LPS tolerance. J Leukoc Biol. 2012 Sep; 92(3):611-20. PMID: 22782967.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  126. Szabo G, Lippai D. Molecular hepatic carcinogenesis: impact of inflammation. Dig Dis. 2012; 30(3):243-8. PMID: 22722548.
    Citations: 7     Fields:    Translation:HumansCells
  127. Ward J, Bala S, Petrasek J, Szabo G. Plasma microRNA profiles distinguish lethal injury in acetaminophen toxicity: a research study. World J Gastroenterol. 2012 Jun 14; 18(22):2798-804. PMID: 22719188.
    Citations: 9     Fields:    Translation:Animals
  128. Morishima C, Shiffman ML, Dienstag JL, Lindsay KL, Szabo G, Everson GT, Lok AS, Di Bisceglie AM, Ghany MG, Naishadham D, Morgan TR, Wright EC. Reduction in Hepatic Inflammation Is Associated With Less Fibrosis Progression and Fewer Clinical Outcomes in Advanced Hepatitis C. Am J Gastroenterol. 2012 Sep; 107(9):1388-98. PMID: 22688849.
    Citations: 7     Fields:    Translation:Humans
  129. Szabo G, Csak T. Inflammasomes in liver diseases. J Hepatol. 2012 Sep; 57(3):642-54. PMID: 22634126.
    Citations: 146     Fields:    Translation:HumansCells
  130. Szabo G, Sarnow P, Bala S. MicroRNA silencing and the development of novel therapies for liver disease. J Hepatol. 2012 Aug; 57(2):462-6. PMID: 22504335.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  131. Levin I, Petrasek J, Szabo G. The presence of p47phox in liver parenchymal cells is a key mediator in the pathogenesis of alcoholic liver steatosis. Alcohol Clin Exp Res. 2012 Aug; 36(8):1397-406. PMID: 22376231.
    Citations: 6     Fields:    Translation:AnimalsCells
  132. Nath B, Szabo G. Hypoxia and hypoxia inducible factors: diverse roles in liver diseases. Hepatology. 2012 Feb; 55(2):622-33. PMID: 22120903.
    Citations: 88     Fields:    Translation:HumansAnimals
  133. Bukong TN, Lo T, Szabo G, Dolganiuc A. Novel developmental biology-based protocol of embryonic stem cell differentiation to morphologically sound and functional yet immature hepatocytes. Liver Int. 2012 May; 32(5):732-41. PMID: 22292891.
    Citations: 8     Fields:    Translation:HumansCells
  134. Bala S, Szabo G. MicroRNA Signature in Alcoholic Liver Disease. Int J Hepatol. 2012; 2012:498232. PMID: 22518321.
    Citations: 43     
  135. Mandrekar P, Ambade A, Lim A, Szabo G, Catalano D. An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice. Hepatology. 2011 Dec; 54(6):2185-97. PMID: 21826694.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  136. Ward J, Szabo G, McManus D, Boyer E. Advanced molecular biologic techniques in toxicologic disease. J Med Toxicol. 2011 Dec; 7(4):288-94. PMID: 22072091.
    Citations: 1     Fields:    Translation:Humans
  137. Ganz M, Csak T, Nath B, Szabo G. Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver. World J Gastroenterol. 2011 Nov 21; 17(43):4772-8. PMID: 22147977.
    Citations: 49     Fields:    Translation:Animals
  138. Pang M, Bala S, Kodys K, Catalano D, Szabo G. Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 2011 Sep 30; 12:55. PMID: 21962237.
    Citations: 18     Fields:    Translation:HumansCells
  139. Csak T, Ganz M, Pespisa J, Kodys K, Dolganiuc A, Szabo G. Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology. 2011 Jul; 54(1):133-44. PMID: 21488066.
    Citations: 204     Fields:    Translation:AnimalsCells
  140. Dienstag JL, Ghany MG, Morgan TR, Di Bisceglie AM, Bonkovsky HL, Kim HY, Seeff LB, Szabo G, Wright EC, Sterling RK, Everson GT, Lindsay KL, Lee WM, Lok AS, Morishima C, Stoddard AM, Everhart JE. A prospective study of the rate of progression in compensated, histologically advanced chronic hepatitis C. Hepatology. 2011 Aug; 54(2):396-405. PMID: 21520194.
    Citations: 43     Fields:    Translation:Humans
  141. Szabo G, Zakhari S. Mechanisms of alcohol-mediated hepatotoxicity in human-immunodeficiency-virus-infected patients. World J Gastroenterol. 2011 May 28; 17(20):2500-6. PMID: 21633654.
    Citations: 11     Fields:    Translation:Humans
  142. Szabo G, Billiar TR, Machida K, Crispe IN, Seki E. Toll-like receptor signaling in liver diseases. Gastroenterol Res Pract. 2010; 2010:971270. PMID: 21789039.
    Citations: 5     
  143. Csak T, Dolganiuc A, Kodys K, Nath B, Petrasek J, Bala S, Lippai D, Szabo G. Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. Hepatology. 2011 Jun; 53(6):1917-31. PMID: 21425308.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  144. Nath B, Levin I, Csak T, Petrasek J, Mueller C, Kodys K, Catalano D, Mandrekar P, Szabo G. Hepatocyte-specific hypoxia-inducible factor-1a is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. Hepatology. 2011 May; 53(5):1526-37. PMID: 21520168.
    Citations: 79     Fields:    Translation:AnimalsCells
  145. Szabo G, Bala S, Petrasek J, Gattu A. Gut-liver axis and sensing microbes. Dig Dis. 2010; 28(6):737-44. PMID: 21525758.
    Citations: 60     Fields:    Translation:HumansAnimals
  146. Dolganiuc A, Szabo G. Dendritic cells in hepatitis C infection: can they (help) win the battle? J Gastroenterol. 2011 Apr; 46(4):432-47. PMID: 21327958.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  147. Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S. Innate immunity in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2011 Apr; 300(4):G516-25. PMID: 21252049.
    Citations: 87     Fields:    Translation:HumansCells
  148. Csak T, Velayudham A, Hritz I, Petrasek J, Levin I, Lippai D, Catalano D, Mandrekar P, Dolganiuc A, Kurt-Jones E, Szabo G. Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. Am J Physiol Gastrointest Liver Physiol. 2011 Mar; 300(3):G433-41. PMID: 21233280.
    Citations: 89     Fields:    Translation:AnimalsCells
  149. Petrasek J, Dolganiuc A, Csak T, Nath B, Hritz I, Kodys K, Catalano D, Kurt-Jones E, Mandrekar P, Szabo G. Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells. Hepatology. 2011 Feb; 53(2):649-60. PMID: 21274885.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  150. Bala S, Marcos M, Kodys K, Csak T, Catalano D, Mandrekar P, Szabo G. Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J Biol Chem. 2011 Jan 14; 286(2):1436-44. PMID: 21062749.
    Citations: 165     Fields:    Translation:AnimalsCells
  151. Nath B, Li Y, Carroll JE, Szabo G, Tseng JF, Shah SA. Alcohol exposure as a risk factor for adverse outcomes in elective surgery. J Gastrointest Surg. 2010 Nov; 14(11):1732-41. PMID: 20839071.
    Citations: 22     Fields:    Translation:Humans
  152. Petrasek J, Dolganiuc A, Csak T, Kurt-Jones EA, Szabo G. Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice. Gastroenterology. 2011 Feb; 140(2):697-708.e4. PMID: 20727895.
    Citations: 49     Fields:    Translation:AnimalsCells
  153. Petrasek J, Mandrekar P, Szabo G. Toll-like receptors in the pathogenesis of alcoholic liver disease. Gastroenterol Res Pract. 2010; 2010. PMID: 20827314.
    Citations: 34     
  154. Szabo G. The 40th anniversary of the National Institute on Alcoholism and Alcohol Abuse: the impact on liver disease. Hepatology. 2010 Jul; 52(1):10-2. PMID: 20578124.
    Citations: 1     Fields:    Translation:Humans
  155. Szabo G, Bala S. Alcoholic liver disease and the gut-liver axis. World J Gastroenterol. 2010 Mar 21; 16(11):1321-9. PMID: 20238398.
    Citations: 130     Fields:    Translation:HumansAnimalsCells
  156. Fontana RJ, Sanyal AJ, Ghany MG, Lee WM, Reid AE, Naishadham D, Everson GT, Kahn JA, Di Bisceglie AM, Szabo G, Morgan TR, Everhart JE. Factors that determine the development and progression of gastroesophageal varices in patients with chronic hepatitis C. Gastroenterology. 2010 Jun; 138(7):2321-31, 2331.e1-2. PMID: 20211180.
    Citations: 12     Fields:    Translation:Humans
  157. Szabo G, Wands JR, Eken A, Osna NA, Weinman SA, Machida K, Joe Wang H. Alcohol and hepatitis C virus--interactions in immune dysfunctions and liver damage. Alcohol Clin Exp Res. 2010 Oct; 34(10):1675-86. PMID: 20608905.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  158. Chang S, Kodys K, Szabo G. Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells. Hepatology. 2010 Jan; 51(1):35-42. PMID: 19821521.
    Citations: 28     Fields:    Translation:HumansCells
  159. Szabo G, Mandrekar P. Focus on: Alcohol and the liver. Alcohol Res Health. 2010; 33(1-2):87-96. PMID: 23579939.
    Citations: 9     Fields:    Translation:HumansAnimals
  160. Bala S, Marcos M, Szabo G. Emerging role of microRNAs in liver diseases. World J Gastroenterol. 2009 Dec 07; 15(45):5633-40. PMID: 19960558.
    Citations: 57     Fields:    Translation:HumansCells
  161. Dolganiuc A, Petrasek J, Kodys K, Catalano D, Mandrekar P, Velayudham A, Szabo G. MicroRNA expression profile in Lieber-DeCarli diet-induced alcoholic and methionine choline deficient diet-induced nonalcoholic steatohepatitis models in mice. Alcohol Clin Exp Res. 2009 Oct; 33(10):1704-10. PMID: 19572984.
    Citations: 78     Fields:    Translation:Animals
  162. Mandrekar P, Bala S, Catalano D, Kodys K, Szabo G. The opposite effects of acute and chronic alcohol on lipopolysaccharide-induced inflammation a