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profileDominic M. Walsh, Ph.D.

TitleAssociate Professor of Neurology
InstitutionBrigham and Women's Hospital
DepartmentNeurology
AddressHarvard Institutes of Medicine
Ctr for Neurologic Disease - HIM 921b
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/525-5059
Fax617/525-5252
vCardDownload vCard (login for email)

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AG047505     (WALSH, DOMINIC MARTIN)Sep 1, 2015 - Apr 30, 2017
NIH/NIA
Exploiting PrP for the diagnosis and treatment of protein aggregation diseases
Role: Principal Investigator

R01AG046275     (WALSH, DOMINIC MARTIN)May 15, 2014 - Apr 30, 2019
NIH/NIA
Water-soluble Abeta and its role in Alzheimer's disease
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhang D, Mably AJ, Walsh DM, Rowan MJ. Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid ß- and TNFa- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus. Cereb Cortex. 2017 Jul 01; 27(7):3724-3735. PMID: 27390019.
    View in: PubMed
  2. Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Large Soluble Oligomers of Amyloid ß-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. J Neurosci. 2017 Jan 04; 37(1):152-163. PMID: 28053038.
    View in: PubMed
  3. Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A. Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. Cancer Cell. 2017 Jan 09; 31(1):142-156. PMID: 28017613.
    View in: PubMed
  4. O'Malley TT, Witbold WM, Linse S, Walsh DM. The Aggregation Paths and Products of Aß42 Dimers Are Distinct from Those of the Aß42 Monomer. Biochemistry. 2016 Nov 08; 55(44):6150-6161. PMID: 27750419.
    View in: PubMed
  5. Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL. Non-Fibrillar Oligomeric Amyloid-ß within Synapses. J Alzheimers Dis. 2016 May 30; 53(3):787-800. PMID: 27258414.
    View in: PubMed
  6. Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nat Rev Neurosci. 2016 Apr; 17(4):251-60. PMID: 26988744.
    View in: PubMed
  7. Szczepankiewicz O, Linse B, Meisl G, Thulin E, Frohm B, Sala Frigerio C, Colvin MT, Jacavone AC, Griffin RG, Knowles T, Walsh DM, Linse S. N-Terminal Extensions Retard Aß42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aß42. J Am Chem Soc. 2015 Nov 25; 137(46):14673-85. PMID: 26535489.
    View in: PubMed
  8. Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S. Soluble Aß oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance. Neurobiol Dis. 2016 Jan; 85:111-121. PMID: 26525100; PMCID: PMC4778388 [Available on 01/01/17].
  9. Phay M, Welzel AT, Williams AD, McWilliams-Koeppen HP, Blinder V, O'Malley TT, Solomon A, Walsh DM, O'Nuallain B. IgG Conformer's Binding to Amyloidogenic Aggregates. PLoS One. 2015; 10(9):e0137344. PMID: 26367058; PMCID: PMC4569075.
  10. Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M. Autoregulated paracellular clearance of amyloid-ß across the blood-brain barrier. Sci Adv. 2015 Sep 04; 1(8):e1500472. PMID: 26491725.
    View in: PubMed
  11. Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P. Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-ß Aggregates. Adv Healthc Mater. 2015 Aug 19. PMID: 26288378.
    View in: PubMed
  12. Cantlon A, Frigerio CS, Walsh DM. Lessons from a Rare Familial Dementia: Amyloid and Beyond. J Parkinsons Dis Alzheimers Dis. 2015 Aug; 2(1). PMID: 26405694.
    View in: PubMed
  13. Guan Y, Cao KJ, Cantlon A, Elbel K, Theodorakis EA, Walsh DM, Yang J, Shah JV. Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy. ACS Chem Neurosci. 2015 Sep 16; 6(9):1503-8. PMID: 26212450; PMCID: PMC4814290.
  14. Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. J Neurosci. 2015 Jul 29; 35(30):10851-65. PMID: 26224867.
    View in: PubMed
  15. Mably AJ, Liu W, Mc Donald JM, Dodart JC, Bard F, Lemere CA, O'Nuallain B, Walsh DM. Anti-Aß antibodies incapable of reducing cerebral Aß oligomers fail to attenuate spatial reference memory deficits in J20 mice. Neurobiol Dis. 2015 Oct; 82:372-384. PMID: 26215784; PMCID: PMC4641028 [Available on 10/01/16].
  16. Cantlon A, Frigerio CS, Freir DB, Boland B, Jin M, Walsh DM. The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers. J Biol Chem. 2015 Jul 03; 290(27):16502-16. PMID: 25957407; PMCID: PMC4505405.
  17. Levites Y, O'Nuallain B, Puligedda RD, Ondrejcak T, Adekar SP, Chen C, Cruz PE, Rosario AM, Macy S, Mably AJ, Walsh DM, Vidal R, Solomon A, Brown D, Rowan MJ, Golde TE, Dessain SK. A human monoclonal IgG that binds aß assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. J Neurosci. 2015 Apr 22; 35(16):6265-76. PMID: 25904780; PMCID: PMC4405548.
  18. Mc Donald JM, O'Malley TT, Liu W, Mably AJ, Brinkmalm G, Portelius E, Wittbold WM, Frosch MP, Walsh DM. The aqueous phase of Alzheimer's disease brain contains assemblies built from ~4 and ~7 kDa Aß species. Alzheimers Dement. 2015 Nov; 11(11):1286-305. PMID: 25846299; PMCID: PMC4592782 [Available on 11/01/16].
  19. Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aß oligomers in human cerebrospinal fluid. Alzheimers Res Ther. 2015; 7(1):14. PMID: 25802556; PMCID: PMC4369838.
  20. Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM. Tau immunization: a cautionary tale? Neurobiol Aging. 2015 Mar; 36(3):1316-32. PMID: 25619661.
    View in: PubMed
  21. O'Malley TT, Oktaviani NA, Zhang D, Lomakin A, O'Nuallain B, Linse S, Benedek GB, Rowan MJ, Mulder FA, Walsh DM. Aß dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies. Biochem J. 2014 Aug 01; 461(3):413-26. PMID: 24785004.
    View in: PubMed
  22. Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 2014 Jun 24; 53(24):3908-21. PMID: 24840308; PMCID: PMC4070750.
  23. Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O'Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I. APP homodimers transduce an amyloid-ß-mediated increase in release probability at excitatory synapses. Cell Rep. 2014 Jun 12; 7(5):1560-1576. PMID: 24835997.
    View in: PubMed
  24. Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J. Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aß synaptotoxicity. J Neurosci. 2014 Apr 30; 34(18):6140-5. PMID: 24790184; PMCID: PMC4004804.
  25. Mittag JJ, Milani S, Walsh DM, Rädler JO, McManus JJ. Simultaneous measurement of a range of particle sizes during Aß1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy. Biochem Biophys Res Commun. 2014 May 30; 448(2):195-9. PMID: 24769478.
    View in: PubMed
  26. Phay M, Blinder V, Macy S, Greene MJ, Wooliver DC, Liu W, Planas A, Walsh DM, Connors LH, Primmer SR, Planque SA, Paul S, O'Nuallain B. Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils. Rejuvenation Res. 2014 Apr; 17(2):97-104. PMID: 24164623.
    View in: PubMed
  27. Hu NW, Nicoll AJ, Zhang D, Mably AJ, O'Malley T, Purro SA, Terry C, Collinge J, Walsh DM, Rowan MJ. mGlu5 receptors and cellular prion protein mediate amyloid-ß-facilitated synaptic long-term depression in vivo. Nat Commun. 2014 Mar 04; 5:3374. PMID: 24594908; PMCID: PMC4354159.
  28. Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet. 2014 Jul 01; 23(13):3523-36. PMID: 24524897; PMCID: PMC4049307.
  29. Métais C, Brennan K, Mably AJ, Scott M, Walsh DM, Herron CE. Simvastatin treatment preserves synaptic plasticity in AßPPswe/PS1dE9 mice. J Alzheimers Dis. 2014; 39(2):315-29. PMID: 24164738.
    View in: PubMed
  30. Klyubin I, Ondrejcak T, Hayes J, Cullen WK, Mably AJ, Walsh DM, Rowan MJ. Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer's disease Aß in vivo. Philos Trans R Soc Lond B Biol Sci. 2014 Jan 05; 369(1633):20130147. PMID: 24298149; PMCID: PMC3843879.
  31. An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH. Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo. Mol Brain. 2013 Nov 13; 6:47. PMID: 24284042; PMCID: PMC4222117.
  32. Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, Vanderburg C, Krichevsky AM. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Hum Mol Genet. 2013 Aug 01; 22(15):3077-92. PMID: 23585551.
    View in: PubMed
  33. Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid ß-protein detect natural Aß oligomers in human brain but not CSF. Alzheimers Dement. 2013 Mar; 9(2):99-112. PMID: 23375565; PMCID: PMC3604133.
  34. Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J. Amyloid-ß nanotubes are associated with prion protein-dependent synaptotoxicity. Nat Commun. 2013; 4:2416. PMID: 24022506; PMCID: PMC3908552.
  35. O'Dowd ST, Ardah MT, Johansson P, Lomakin A, Benedek GB, Roberts KA, Cummins G, El Agnaf OM, Svensson J, Zetterberg H, Lynch T, Walsh DM. The ELISA-measured increase in cerebrospinal fluid tau that discriminates Alzheimer's disease from other neurodegenerative disorders is not attributable to differential recognition of tau assembly forms. J Alzheimers Dis. 2013; 33(4):923-8. PMID: 23034520.
    View in: PubMed
  36. Welzel AT, Williams AD, McWilliams-Koeppen HP, Acero L, Weber A, Blinder V, Mably A, Bunk S, Hermann C, Farrell MA, Ehrlich HJ, Schwarz HP, Walsh DM, Solomon A, O'Nuallain B. Human anti-Aß IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide. PLoS One. 2012; 7(11):e50317. PMID: 23209707; PMCID: PMC3507685.
  37. Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Sala Frigerio C, Regan CM, Murphy KJ, Masliah E, Walsh DM. Alzheimer brain-derived amyloid ß-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013 May; 34(5):1315-27. PMID: 23182244; PMCID: PMC3570694.
  38. Moro ML, Giaccone G, Lombardi R, Indaco A, Uggetti A, Morbin M, Saccucci S, Di Fede G, Catania M, Walsh DM, Demarchi A, Rozemuller A, Bogdanovic N, Bugiani O, Ghetti B, Tagliavini F. APP mutations in the Aß coding region are associated with abundant cerebral deposition of Aß38. Acta Neuropathol. 2012 Dec; 124(6):809-21. PMID: 23143229.
    View in: PubMed
  39. Kim YY, Williams D, Meldrum FC, Walsh D. Simple photosystem II water oxidation centre analogues in visible light oxygen and H+ generation. Small. 2013 Jan 14; 9(1):61-6. PMID: 23038668.
    View in: PubMed
  40. Cukalevski R, Boland B, Frohm B, Thulin E, Walsh D, Linse S. Role of aromatic side chains in amyloid ß-protein aggregation. ACS Chem Neurosci. 2012 Dec 19; 3(12):1008-16. PMID: 23259036; PMCID: PMC3526965.
  41. Nicholson AM, Wold LA, Walsh DM, Ferreira A. ß-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons. Mol Med. 2012 Mar 27; 18:178-85. PMID: 22160219; PMCID: PMC3320137.
  42. McDonald JM, Cairns NJ, Taylor-Reinwald L, Holtzman D, Walsh DM. The levels of water-soluble and triton-soluble Aß are increased in Alzheimer's disease brain. Brain Res. 2012 Apr 23; 1450:138-47. PMID: 22440675; PMCID: PMC3319647.
  43. Walsh DM, Teplow DB. Alzheimer's disease and the amyloid ß-protein. Prog Mol Biol Transl Sci. 2012; 107:101-24. PMID: 22482449.
    View in: PubMed
  44. Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, Frank RF, Reif B, Günther S, Walsh DM, Wanker EE. Small-molecule conversion of toxic oligomers to nontoxic ß-sheet-rich amyloid fibrils. Nat Chem Biol. 2011 Nov 20; 8(1):93-101. PMID: 22101602.
    View in: PubMed
  45. O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM. A monoclonal antibody against synthetic Aß dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aß. J Neurochem. 2011 Oct; 119(1):189-201. PMID: 21781116; PMCID: PMC3174526.
  46. Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J. Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites. Nat Commun. 2011 Jun 07; 2:336. PMID: 21654636; PMCID: PMC3156817.
  47. Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, Walsh DM, Rowan MJ. Alzheimer's disease brain-derived amyloid-ß-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J Neurosci. 2011 May 18; 31(20):7259-63. PMID: 21593310.
    View in: PubMed
  48. Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J. Extracellular phosphorylation of the amyloid ß-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO J. 2011 Jun 01; 30(11):2255-65. PMID: 21527912; PMCID: PMC3117653.
  49. Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5819-24. PMID: 21421841; PMCID: PMC3078381.
  50. Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Isolation of low-n amyloid ß-protein oligomers from cultured cells, CSF, and brain. Methods Mol Biol. 2011; 670:33-44. PMID: 20967581.
    View in: PubMed
  51. O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM. Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils. J Neurosci. 2010 Oct 27; 30(43):14411-9. PMID: 20980598; PMCID: PMC2987723.
  52. Welzel AT, Walsh DM. Aberrant protein structure and diseases of the brain. Ir J Med Sci. 2011 Mar; 180(1):15-22. PMID: 20960238.
    View in: PubMed
  53. Boland B, Smith DA, Mooney D, Jung SS, Walsh DM, Platt FM. Macroautophagy is not directly involved in the metabolism of amyloid precursor protein. J Biol Chem. 2010 Nov 26; 285(48):37415-26. PMID: 20864542; PMCID: PMC2988347.
  54. Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain. 2010 May; 133(Pt 5):1328-41. PMID: 20403962; PMCID: PMC2859152.
  55. Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. FEBS J. 2010 Mar; 277(6):1503-18. PMID: 20163459; PMCID: PMC2847843.
  56. Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aß oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiol Aging. 2011 Dec; 32(12):2211-8. PMID: 20097446; PMCID: PMC2891223.
  57. Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Sherman MA, Lesné S, LaDu MJ, Walsh DM, Ashe KH, Cleary JP. Cognitive effects of cell-derived and synthetically derived Aß oligomers. Neurobiol Aging. 2011 Oct; 32(10):1784-94. PMID: 20031278; PMCID: PMC2895944.
  58. Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry. 2009 Nov 24; 48(46):10894-904. PMID: 19821615; PMCID: PMC4489158.
  59. Shankar GM, Walsh DM. Alzheimer's disease: synaptic dysfunction and Abeta. Mol Neurodegener. 2009 Nov 23; 4:48. PMID: 19930651; PMCID: PMC2788538.
  60. Hellstrand E, Boland B, Walsh DM, Linse S. Amyloid ß-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process. ACS Chem Neurosci. 2010 Jan 20; 1(1):13-8. PMID: 22778803; PMCID: PMC3368626.
  61. Hampel H, Shen Y, Walsh DM, Aisen P, Shaw LM, Zetterberg H, Trojanowski JQ, Blennow K. Biological markers of amyloid beta-related mechanisms in Alzheimer's disease. Exp Neurol. 2010 Jun; 223(2):334-46. PMID: 19815015; PMCID: PMC2896007.
  62. Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis. 2009 Nov; 36(2):293-302. PMID: 19660551; PMCID: PMC2782414.
  63. Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 2009 Jun 25; 62(6):788-801. PMID: 19555648; PMCID: PMC2702854.
  64. Walsh DM, Thulin E, Minogue AM, Gustavsson N, Pang E, Teplow DB, Linse S. A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide. FEBS J. 2009 Mar; 276(5):1266-81. PMID: 19175671; PMCID: PMC2702495.
  65. Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch Neurol. 2009 Feb; 66(2):190-9. PMID: 19204155; PMCID: PMC3618974.
  66. Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Res. 2009 Mar 25; 1262:89-99. PMID: 19401174.
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  67. Green DW, Bolland BJ, Kanczler JM, Lanham SA, Walsh D, Mann S, Oreffo RO. Augmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites. Biomaterials. 2009 Apr; 30(10):1918-27. PMID: 19135716.
    View in: PubMed
  68. O'Shea SD, Smith IM, McCabe OM, Cronin MM, Walsh DM, O'Connor WT. Intracerebroventricular Administration of Amyloid ß-protein Oligomers Selectively Increases Dorsal Hippocampal Dialysate Glutamate Levels in the Awake Rat. Sensors (Basel). 2008 Nov 19; 8(11):7428-7437. PMID: 27873937.
    View in: PubMed
  69. Cabaleiro-Lago C, Quinlan-Pluck F, Lynch I, Lindman S, Minogue AM, Thulin E, Walsh DM, Dawson KA, Linse S. Inhibition of amyloid beta protein fibrillation by polymeric nanoparticles. J Am Chem Soc. 2008 Nov 19; 130(46):15437-43. PMID: 18954050.
    View in: PubMed
  70. Hu NW, Smith IM, Walsh DM, Rowan MJ. Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo. Brain. 2008 Sep; 131(Pt 9):2414-24. PMID: 18678563.
    View in: PubMed
  71. Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM. Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Mol Med. 2008 Jul-Aug; 14(7-8):451-64. PMID: 18368143; PMCID: PMC2274891.
  72. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug; 14(8):837-42. PMID: 18568035; PMCID: PMC2772133.
  73. Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiol Dis. 2008 Sep; 31(3):442-50. PMID: 18602473; PMCID: PMC3160758.
  74. Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Substrate-targeting gamma-secretase modulators. Nature. 2008 Jun 12; 453(7197):925-9. PMID: 18548070; PMCID: PMC2678541.
  75. Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci. 2008 Apr 16; 28(16):4231-7. PMID: 18417702; PMCID: PMC2685151.
  76. McDonough SM, Liddle SD, Hunter R, Walsh DM, Glasgow P, Gormley G, Hurley D, Delitto A, Park J, Bradbury I, Baxter GD. Exercise and manual auricular acupuncture: a pilot assessor-blind randomised controlled trial. (The acupuncture and personalised exercise programme (APEP) trial). BMC Musculoskelet Disord. 2008 Mar 06; 9:31. PMID: 18325114; PMCID: PMC2322991.
  77. Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol. 2007 Jul; 171(1):241-51. PMID: 17591969; PMCID: PMC1941603.
  78. Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochem Soc Trans. 2007 Apr; 35(Pt 2):416-20. PMID: 17371289.
    View in: PubMed
  79. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14; 27(11):2866-75. PMID: 17360908.
    View in: PubMed
  80. Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. J Neurochem. 2007 Jun; 101(5):1172-84. PMID: 17286590.
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  81. Walsh DM, Finwall J, Touchette PE, McGregor MR, Fernandez GE, Lott IT, Sandman CA. Rapid assessment of severe cognitive impairment in individuals with developmental disabilities. J Intellect Disabil Res. 2007 Feb; 51(Pt 2):91-100. PMID: 17217473.
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  82. Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Ann Neurol. 2006 Dec; 60(6):668-76. PMID: 17192927.
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  83. Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, Wetzel R, Wexler NS, Young AB, Bain L. Common threads in neurodegenerative disorders of aging. Alzheimers Dement. 2006 Oct; 2(4):322-6. PMID: 19595906.
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  84. Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science. 2006 Sep 22; 313(5794):1781-4. PMID: 16990547.
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  85. Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol. 2006 Apr 15; 572(Pt 2):477-92. PMID: 16469784; PMCID: PMC1779683.
  86. Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1087-90. PMID: 16246051.
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  87. Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med. 2005 May; 11(5):556-61. PMID: 15834427.
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  88. Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J Neurosci. 2005 Mar 09; 25(10):2455-62. PMID: 15758153.
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  89. Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci. 2005 Jan; 8(1):79-84. PMID: 15608634.
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  90. Seabrook TJ, Bloom JK, Iglesias M, Spooner ET, Walsh DM, Lemere CA. Species-specific immune response to immunization with human versus rodent A beta peptide. Neurobiol Aging. 2004 Oct; 25(9):1141-51. PMID: 15312960.
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  91. Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron. 2004 Sep 30; 44(1):181-93. PMID: 15450169.
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  92. Ye C, Walsh DM, Selkoe DJ, Hartley DM. Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neurosci Lett. 2004 Aug 19; 366(3):320-5. PMID: 15288443.
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  93. Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein Pept Lett. 2004 Jun; 11(3):213-28. PMID: 15182223.
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  94. Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. Eur J Neurosci. 2004 May; 19(10):2839-46. PMID: 15147317.
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  95. Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. J Neurosci. 2004 Mar 31; 24(13):3370-8. PMID: 15056716.
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  96. Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003 Dec 18; 40(6):1087-93. PMID: 14687544.
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  97. El-Agnaf OM, Walsh DM, Allsop D. Soluble oligomers for the diagnosis of neurodegenerative diseases. Lancet Neurol. 2003 Aug; 2(8):461-2. PMID: 12878433.
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  98. Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 2003 Jun 10; 42(22):6664-73. PMID: 12779321.
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  99. Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid. 2003 Mar; 10(1):51-61. PMID: 12762144.
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  100. Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 2003 Feb 20; 37(4):583-95. PMID: 12597857.
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  101. Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans. 2002 Aug; 30(4):552-7. PMID: 12196135.
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  102. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 2002 Apr 04; 416(6880):535-9. PMID: 11932745.
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  103. Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB. In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease. Biochem J. 2001 May 01; 355(Pt 3):869-77. PMID: 11311152; PMCID: PMC1221805.
  104. Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, Teplow DB. A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils. Nat Struct Biol. 2000 Dec; 7(12):1095-9. PMID: 11101888.
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  105. Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry. 2000 Sep 05; 39(35):10831-9. PMID: 10978169.
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  106. Fezoui Y, Hartley DM, Harper JD, Khurana R, Walsh DM, Condron MM, Selkoe DJ, Lansbury PT, Fink AL, Teplow DB. An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid. 2000 Sep; 7(3):166-78. PMID: 11019857.
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  107. Barlas P, Craig JA, Robinson J, Walsh DM, Baxter GD, Allen JM. Managing delayed-onset muscle soreness: lack of effect of selected oral systemic analgesics. Arch Phys Med Rehabil. 2000 Jul; 81(7):966-72. PMID: 10896014.
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  108. Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci. 1999 Oct 15; 19(20):8876-84. PMID: 10516307.
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  109. Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem. 1999 Sep 03; 274(36):25945-52. PMID: 10464339.
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  110. Craig JA, Bradley J, Walsh DM, Baxter GD, Allen JM. Delayed onset muscle soreness: lack of effect of therapeutic ultrasound in humans. Arch Phys Med Rehabil. 1999 Mar; 80(3):318-23. PMID: 10084441.
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  111. Craig JA, Barron J, Walsh DM, Baxter GD. Lack of effect of combined low intensity laser therapy/phototherapy (CLILT) on delayed onset muscle soreness in humans. Lasers Surg Med. 1999; 24(3):223-30. PMID: 10229153.
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  112. Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem. 1998 Dec 04; 273(49):32730-8. PMID: 9830016.
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  113. El-Agnaf OM, Guthrie DJ, Walsh DM, Irvine GB. The influence of the central region containing residues 19-25 on the aggregation properties and secondary structure of Alzheimer's beta-amyloid peptide. Eur J Biochem. 1998 Sep 15; 256(3):560-9. PMID: 9780232.
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  114. Podlisny MB, Walsh DM, Amarante P, Ostaszewski BL, Stimson ER, Maggio JE, Teplow DB, Selkoe DJ. Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry. 1998 Mar 17; 37(11):3602-11. PMID: 9521679.
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  115. Walsh DM, Lomakin A, Benedek GB, Condron MM, Teplow DB. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J Biol Chem. 1997 Aug 29; 272(35):22364-72. PMID: 9268388.
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  116. Clements A, Allsop D, Walsh DM, Williams CH. Aggregation and metal-binding properties of mutant forms of the amyloid A beta peptide of Alzheimer's disease. J Neurochem. 1996 Feb; 66(2):740-7. PMID: 8592147.
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  117. el-Agnaf OM, Irvine GB, Guthrie DJ, Walsh DM. Properties of some peptides related to amyloid beta-peptide. Biochem Soc Trans. 1996 Feb; 24(1):59S. PMID: 8674733.
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  118. Beresford IJ, Sheldrick RL, Ball DI, Turpin MP, Walsh DM, Hawcock AB, Coleman RA, Hagan RM, Tyers MB. GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. Eur J Pharmacol. 1995 Jan 16; 272(2-3):241-8. PMID: 7713168.
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  119. Stables JM, Beresford IJ, Arkinstall S, Ireland SJ, Walsh DM, Seale PW, Ward P, Hagan RM. GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors. Neuropeptides. 1994 Dec; 27(6):333-41. PMID: 7534879.
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  120. Walsh DM, Williams CH, Kennedy HE, Allsop D. An investigation into the proteolytic cleavage of Alzheimer amyloid precursor protein in PC-12 cells. Biochem Soc Trans. 1994 Feb; 22(1):14S. PMID: 8206210.
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  121. Clements A, Walsh DM, Williams CH, Allsop D. Aggregation of Alzheimer's peptides. Biochem Soc Trans. 1994 Feb; 22(1):16S. PMID: 8206215.
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  122. Walsh DM, Williams CH, Kennedy HE, Allsop D, Murphy G. Gelatinase A not alpha-secretase? Nature. 1994 Jan 06; 367(6458):27-8. PMID: 7906388.
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  123. Clements A, Walsh DM, Williams CH, Allsop D. Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid beta/A4 peptide. Neurosci Lett. 1993 Oct 14; 161(1):17-20. PMID: 7902973.
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  124. Williams CH, Yamamoto T, Walsh DM, Allsop D. Endopeptidase 3.4.24.11 converts N-1-(R,S)carboxy-3-phenylpropyl-Ala-Ala-Phe-p-carboxyanilide into a potent inhibitor of angiotensin-converting enzyme. Biochem J. 1993 Sep 15; 294 ( Pt 3):681-4. PMID: 8379924; PMCID: PMC1134516.
  125. Elliott PJ, Walsh DM, Close SP. Dopamine D1 and D2 receptor interactions in the MPTP-treated marmoset. Neurosci Lett. 1992 Aug 03; 142(1):1-4. PMID: 1357609.
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  126. Walsh DM, Kennedy S, Blanchflower WJ, Kennedy DG. The effect of vitamin E and/or selenium depletion on tissue peroxidation and peroxidisability in ruminant cattle. Biochem Soc Trans. 1991 Feb; 19(1):61S. PMID: 2037192.
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