Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Dominic M. Walsh, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AG056753 (SELKOE, DENNIS J) Aug 15, 2018 - Nov 30, 2020
    A new look at mechanism-based Alzheimer's Disease biomarkers in blood
    Role: Principal Investigator
  2. R21AG047505 (WALSH, DOMINIC MARTIN) Sep 1, 2015 - Apr 30, 2018
    Exploiting PrP for the diagnosis and treatment of protein aggregation diseases
    Role: Principal Investigator
  3. R01AG046275 (SELKOE, DENNIS J) May 15, 2014 - Apr 30, 2019
    Water-soluble Abeta and its role in Alzheimer's disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wang Z, Jin M, Hong W, Liu W, Reczek D, Lagomarsino VN, Hu Y, Weeden T, Frosch MP, Young-Pearse TL, Pradier L, Selkoe D, Walsh DM. Learnings about Aß from human brain recommend the use of a live-neuron bioassay for the discovery of next generation Alzheimer's disease immunotherapeutics. Acta Neuropathol Commun. 2023 Mar 10; 11(1):39. PMID: 36899414; PMCID: PMC10007750.
    Citations:    Fields:    
  2. Hong W, Liu W, Desousa AO, Young-Pearse T, Walsh DM. Methods for the isolation and analysis of Aß from postmortem brain. Front Neurosci. 2023; 17:1108715. PMID: 36777642; PMCID: PMC9909698.
  3. Mengel D, Mok TH, Nihat A, Liu W, Rissman RA, Galasko D, Zetterberg H, Mead S, Collinge J, Walsh DM. NT1-Tau Is Increased in CSF and Plasma of CJD Patients, and Correlates with Disease Progression. Cells. 2021 12 13; 10(12). PMID: 34944022; PMCID: PMC8700417.
    Citations: 1     Fields:    Translation:Humans
  4. Podracky CJ, An C, DeSousa A, Dorr BM, Walsh DM, Liu DR. Laboratory evolution of a sortase enzyme that modifies amyloid-ß protein. Nat Chem Biol. 2021 03; 17(3):317-325. PMID: 33432237; PMCID: PMC7904614.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  5. Mattsson-Carlgren N, Janelidze S, Palmqvist S, Cullen N, Svenningsson AL, Strandberg O, Mengel D, Walsh DM, Stomrud E, Dage JL, Hansson O. Longitudinal plasma p-tau217 is increased in early stages of Alzheimer's disease. Brain. 2020 12 05; 143(11):3234-3241. PMID: 33068398; PMCID: PMC7719022.
    Citations: 53     Fields:    Translation:HumansCells
  6. Mengel D, Janelidze S, Glynn RJ, Liu W, Hansson O, Walsh DM. Plasma NT1 Tau is a Specific and Early Marker of Alzheimer's Disease. Ann Neurol. 2020 11; 88(5):878-892. PMID: 32829532.
    Citations: 9     Fields:    Translation:Humans
  7. Walsh DM, Selkoe DJ. Amyloid ß-protein and beyond: the path forward in Alzheimer's disease. Curr Opin Neurobiol. 2020 04; 61:116-124. PMID: 32197217.
    Citations: 43     Fields:    Translation:HumansCells
  8. Mengel D, Liu W, Glynn RJ, Selkoe DJ, Strydom A, Lai F, Rosas HD, Torres A, Patsiogiannis V, Skotko B, Walsh DM. Dynamics of plasma biomarkers in Down syndrome: the relative levels of Aß42 decrease with age, whereas NT1 tau and NfL increase. Alzheimers Res Ther. 2020 03 19; 12(1):27. PMID: 32192521.
    Citations: 11     Fields:    Translation:Humans
  9. Corbett GT, Wang Z, Hong W, Colom-Cadena M, Rose J, Liao M, Asfaw A, Hall TC, Ding L, DeSousa A, Frosch MP, Collinge J, Harris DA, Perkinton MS, Spires-Jones TL, Young-Pearse TL, Billinton A, Walsh DM. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins. Acta Neuropathol. 2020 03; 139(3):503-526. PMID: 31853635.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  10. Cha DJ, Mengel D, Mustapic M, Liu W, Selkoe DJ, Kapogiannis D, Galasko D, Rissman RA, Bennett DA, Walsh DM. miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer's Patients. Front Neurosci. 2019; 13:1208. PMID: 31849573; PMCID: PMC6902042.
    Citations: 73     
  11. Zott B, Simon MM, Hong W, Unger F, Chen-Engerer HJ, Frosch MP, Sakmann B, Walsh DM, Konnerth A. A vicious cycle of ß amyloid-dependent neuronal hyperactivation. Science. 2019 08 09; 365(6453):559-565. PMID: 31395777.
    Citations: 164     Fields:    Translation:HumansAnimalsCells
  12. Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ. Target engagement in an alzheimer trial: Crenezumab lowers amyloid ß oligomers in cerebrospinal fluid. Ann Neurol. 2019 08; 86(2):215-224. PMID: 31168802; PMCID: PMC6771589.
    Citations: 31     Fields:    Translation:HumansCTClinical Trials
  13. Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM. Identification of neurotoxic cross-linked amyloid-ß dimers in the Alzheimer's brain. Brain. 2019 05 01; 142(5):1441-1457. PMID: 31032851; PMCID: PMC6487330.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  14. Ondrejcak T, Hu NW, Qi Y, Klyubin I, Corbett GT, Fraser G, Perkinton MS, Walsh DM, Billinton A, Rowan MJ. Soluble tau aggregates inhibit synaptic long-term depression and amyloid ß-facilitated LTD in vivo. Neurobiol Dis. 2019 07; 127:582-590. PMID: 30910746.
    Citations: 11     Fields:    Translation:AnimalsCells
  15. Mengel D, Hong W, Corbett GT, Liu W, DeSousa A, Solforosi L, Fang C, Frosch MP, Collinge J, Harris DA, Walsh DM. PrP-grafted antibodies bind certain amyloid ß-protein aggregates, but do not prevent toxicity. Brain Res. 2019 05 01; 1710:125-135. PMID: 30593771.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  16. Purro SA, Farrow MA, Linehan J, Nazari T, Thomas DX, Chen Z, Mengel D, Saito T, Saido T, Rudge P, Brandner S, Walsh DM, Collinge J. Transmission of amyloid-ß protein pathology from cadaveric pituitary growth hormone. Nature. 2018 12; 564(7736):415-419. PMID: 30546139.
    Citations: 57     Fields:    Translation:HumansAnimalsPHPublic Health
  17. Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimers Dement. 2019 03; 15(3):487-496. PMID: 30419228; PMCID: PMC6476313.
    Citations: 40     Fields:    Translation:HumansCells
  18. Ondrejcak T, Klyubin I, Corbett GT, Fraser G, Hong W, Mably AJ, Gardener M, Hammersley J, Perkinton MS, Billinton A, Walsh DM, Rowan MJ. Cellular Prion Protein Mediates the Disruption of Hippocampal Synaptic Plasticity by Soluble Tau In Vivo. J Neurosci. 2018 12 12; 38(50):10595-10606. PMID: 30355631; PMCID: PMC6290298.
    Citations: 31     Fields:    Translation:HumansAnimals
  19. Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM. An in vitro paradigm to assess potential anti-Aß antibodies for Alzheimer's disease. Nat Commun. 2018 07 11; 9(1):2676. PMID: 29992960.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  20. El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM. MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways. Acta Neuropathol. 2018 10; 136(4):537-555. PMID: 29982852; PMCID: PMC6132948.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  21. Hu NW, Corbett GT, Moore S, Klyubin I, O'Malley TT, Walsh DM, Livesey FJ, Rowan MJ. Extracellular Forms of Aß and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity. Cell Rep. 2018 05 15; 23(7):1932-1938. PMID: 29768194.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  22. Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM. Diffusible, highly bioactive oligomers represent a critical minority of soluble Aß in Alzheimer's disease brain. Acta Neuropathol. 2018 07; 136(1):19-40. PMID: 29687257; PMCID: PMC6647843.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  23. Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM. Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles. Int J Mol Sci. 2018 Feb 27; 19(3). PMID: 29495441.
    Citations: 84     Fields:    Translation:HumansCells
  24. O'Malley TT, Linse S, Walsh DM. Production and Use of Recombinant Aß for Aggregation Studies. Methods Mol Biol. 2018; 1777:307-320. PMID: 29744844; PMCID: PMC6660832.
    Citations: 3     Fields:    Translation:Cells
  25. Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse TL, Spires-Jones TL, Walsh DM. Human Brain-Derived Aß Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP. J Neurosci. 2017 12 06; 37(49):11947-11966. PMID: 29101243.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  26. Sarell CJ, Quarterman E, Yip DC, Terry C, Nicoll AJ, Wadsworth JDF, Farrow MA, Walsh DM, Collinge J. Soluble Aß aggregates can inhibit prion propagation. Open Biol. 2017 11; 7(11). PMID: 29142106.
    Citations: 7     Fields:    Translation:AnimalsCells
  27. Zhang D, Mably AJ, Walsh DM, Rowan MJ. Peripheral Interventions Enhancing Brain Glutamate Homeostasis Relieve Amyloid ß- and TNFa- Mediated Synaptic Plasticity Disruption in the Rat Hippocampus. Cereb Cortex. 2017 07 01; 27(7):3724-3735. PMID: 27390019; PMCID: PMC5967354.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  28. Yang T, Li S, Xu H, Walsh DM, Selkoe DJ. Large Soluble Oligomers of Amyloid ß-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. J Neurosci. 2017 01 04; 37(1):152-163. PMID: 28053038; PMCID: PMC5214627.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  29. Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A. Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. Cancer Cell. 2017 01 09; 31(1):142-156. PMID: 28017613; PMCID: PMC5363285.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  30. O'Malley TT, Witbold WM, Linse S, Walsh DM. The Aggregation Paths and Products of Aß42 Dimers Are Distinct from Those of the Aß42 Monomer. Biochemistry. 2016 Nov 08; 55(44):6150-6161. PMID: 27750419.
    Citations: 11     Fields:    Translation:Cells
  31. Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL. Non-Fibrillar Oligomeric Amyloid-ß within Synapses. J Alzheimers Dis. 2016 05 30; 53(3):787-800. PMID: 27258414.
    Citations: 34     Fields:    Translation:AnimalsCells
  32. Walsh DM, Selkoe DJ. A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nat Rev Neurosci. 2016 Apr; 17(4):251-60. PMID: 26988744; PMCID: PMC6701169.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  33. Szczepankiewicz O, Linse B, Meisl G, Thulin E, Frohm B, Sala Frigerio C, Colvin MT, Jacavone AC, Griffin RG, Knowles T, Walsh DM, Linse S. N-Terminal Extensions Retard Aß42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aß42. J Am Chem Soc. 2015 Nov 25; 137(46):14673-85. PMID: 26535489.
    Citations: 29     Fields:    Translation:Cells
  34. Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S. Soluble Aß oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance. Neurobiol Dis. 2016 Jan; 85:111-121. PMID: 26525100; PMCID: PMC4778388.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  35. Phay M, Welzel AT, Williams AD, McWilliams-Koeppen HP, Blinder V, O'Malley TT, Solomon A, Walsh DM, O'Nuallain B. IgG Conformer's Binding to Amyloidogenic Aggregates. PLoS One. 2015; 10(9):e0137344. PMID: 26367058.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  36. Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M. Autoregulated paracellular clearance of amyloid-ß across the blood-brain barrier. Sci Adv. 2015 Sep 04; 1(8):e1500472. PMID: 26491725.
    Citations: 50     Fields:    
  37. Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P. Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-ß Aggregates. Adv Healthc Mater. 2015 Oct; 4(14):2100-2109. PMID: 26288378.
    Citations: 8     Fields:    
  38. Cantlon A, Frigerio CS, Walsh DM. Lessons from a Rare Familial Dementia: Amyloid and Beyond. J Parkinsons Dis Alzheimers Dis. 2015 Aug; 2(1). PMID: 26405694; PMCID: PMC4578630.
    Citations: 3     
  39. Guan Y, Cao KJ, Cantlon A, Elbel K, Theodorakis EA, Walsh DM, Yang J, Shah JV. Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy. ACS Chem Neurosci. 2015 Sep 16; 6(9):1503-8. PMID: 26212450.
    Citations: 7     Fields:    Translation:Cells
  40. Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM. C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death. J Neurosci. 2015 Jul 29; 35(30):10851-65. PMID: 26224867; PMCID: PMC6605107.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  41. Mably AJ, Liu W, Mc Donald JM, Dodart JC, Bard F, Lemere CA, O'Nuallain B, Walsh DM. Anti-Aß antibodies incapable of reducing cerebral Aß oligomers fail to attenuate spatial reference memory deficits in J20 mice. Neurobiol Dis. 2015 Oct; 82:372-384. PMID: 26215784; PMCID: PMC4641028.
    Citations: 22     Fields:    Translation:HumansAnimals
  42. Cantlon A, Frigerio CS, Freir DB, Boland B, Jin M, Walsh DM. The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers. J Biol Chem. 2015 Jul 03; 290(27):16502-16. PMID: 25957407.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  43. Levites Y, O'Nuallain B, Puligedda RD, Ondrejcak T, Adekar SP, Chen C, Cruz PE, Rosario AM, Macy S, Mably AJ, Walsh DM, Vidal R, Solomon A, Brown D, Rowan MJ, Golde TE, Dessain SK. A human monoclonal IgG that binds aß assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo. J Neurosci. 2015 Apr 22; 35(16):6265-76. PMID: 25904780; PMCID: PMC4405548.
    Citations: 7     Fields:    Translation:HumansAnimals
  44. Mc Donald JM, O'Malley TT, Liu W, Mably AJ, Brinkmalm G, Portelius E, Wittbold WM, Frosch MP, Walsh DM. The aqueous phase of Alzheimer's disease brain contains assemblies built from ~4 and ~7 kDa Aß species. Alzheimers Dement. 2015 Nov; 11(11):1286-305. PMID: 25846299.
    Citations: 30     Fields:    Translation:HumansCells
  45. Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ. A highly sensitive novel immunoassay specifically detects low levels of soluble Aß oligomers in human cerebrospinal fluid. Alzheimers Res Ther. 2015; 7(1):14. PMID: 25802556.
    Citations: 38     Fields:    
  46. Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM. Tau immunization: a cautionary tale? Neurobiol Aging. 2015 Mar; 36(3):1316-32. PMID: 25619661.
    Citations: 16     Fields:    Translation:Animals
  47. O'Malley TT, Oktaviani NA, Zhang D, Lomakin A, O'Nuallain B, Linse S, Benedek GB, Rowan MJ, Mulder FA, Walsh DM. Aß dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies. Biochem J. 2014 Aug 01; 461(3):413-26. PMID: 24785004.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  48. Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ. Secreted amyloid ß-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry. 2014 Jun 24; 53(24):3908-21. PMID: 24840308.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  49. Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O'Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I. APP homodimers transduce an amyloid-ß-mediated increase in release probability at excitatory synapses. Cell Rep. 2014 Jun 12; 7(5):1560-1576. PMID: 24835997.
    Citations: 67     Fields:    Translation:AnimalsCells
  50. Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J. Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aß synaptotoxicity. J Neurosci. 2014 Apr 30; 34(18):6140-5. PMID: 24790184; PMCID: PMC4004804.
    Citations: 38     Fields:    Translation:HumansAnimals
  51. Mittag JJ, Milani S, Walsh DM, Rädler JO, McManus JJ. Simultaneous measurement of a range of particle sizes during Aß1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy. Biochem Biophys Res Commun. 2014 May 30; 448(2):195-9. PMID: 24769478.
    Citations: 8     Fields:    Translation:Humans
  52. Phay M, Blinder V, Macy S, Greene MJ, Wooliver DC, Liu W, Planas A, Walsh DM, Connors LH, Primmer SR, Planque SA, Paul S, O'Nuallain B. Transthyretin aggregate-specific antibodies recognize cryptic epitopes on patient-derived amyloid fibrils. Rejuvenation Res. 2014 Apr; 17(2):97-104. PMID: 24164623.
    Citations: 5     Fields:    Translation:HumansAnimals
  53. Hu NW, Nicoll AJ, Zhang D, Mably AJ, O'Malley T, Purro SA, Terry C, Collinge J, Walsh DM, Rowan MJ. mGlu5 receptors and cellular prion protein mediate amyloid-ß-facilitated synaptic long-term depression in vivo. Nat Commun. 2014 Mar 04; 5:3374. PMID: 24594908; PMCID: PMC4354159.
    Citations: 89     Fields:    Translation:Animals
  54. Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL. The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet. 2014 Jul 01; 23(13):3523-36. PMID: 24524897.
    Citations: 171     Fields:    Translation:HumansCells
  55. Métais C, Brennan K, Mably AJ, Scott M, Walsh DM, Herron CE. Simvastatin treatment preserves synaptic plasticity in AßPPswe/PS1dE9 mice. J Alzheimers Dis. 2014; 39(2):315-29. PMID: 24164738.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  56. Klyubin I, Ondrejcak T, Hayes J, Cullen WK, Mably AJ, Walsh DM, Rowan MJ. Neurotransmitter receptor and time dependence of the synaptic plasticity disrupting actions of Alzheimer's disease Aß in vivo. Philos Trans R Soc Lond B Biol Sci. 2014 Jan 05; 369(1633):20130147. PMID: 24298149.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  57. An K, Klyubin I, Kim Y, Jung JH, Mably AJ, O'Dowd ST, Lynch T, Kanmert D, Lemere CA, Finan GM, Park JW, Kim TW, Walsh DM, Rowan MJ, Kim JH. Exosomes neutralize synaptic-plasticity-disrupting activity of Aß assemblies in vivo. Mol Brain. 2013 Nov 13; 6:47. PMID: 24284042.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  58. Wong HK, Veremeyko T, Patel N, Lemere CA, Walsh DM, Esau C, Vanderburg C, Krichevsky AM. De-repression of FOXO3a death axis by microRNA-132 and -212 causes neuronal apoptosis in Alzheimer's disease. Hum Mol Genet. 2013 Aug 01; 22(15):3077-92. PMID: 23585551.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
  59. Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid ß-protein detect natural Aß oligomers in human brain but not CSF. Alzheimers Dement. 2013 Mar; 9(2):99-112. PMID: 23375565.
    Citations: 54     Fields:    Translation:HumansAnimals
  60. O'Dowd ST, Ardah MT, Johansson P, Lomakin A, Benedek GB, Roberts KA, Cummins G, El Agnaf OM, Svensson J, Zetterberg H, Lynch T, Walsh DM. The ELISA-measured increase in cerebrospinal fluid tau that discriminates Alzheimer's disease from other neurodegenerative disorders is not attributable to differential recognition of tau assembly forms. J Alzheimers Dis. 2013; 33(4):923-8. PMID: 23034520.
    Citations: 7     Fields:    Translation:Humans
  61. Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J. Amyloid-ß nanotubes are associated with prion protein-dependent synaptotoxicity. Nat Commun. 2013; 4:2416. PMID: 24022506; PMCID: PMC3908552.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  62. Welzel AT, Williams AD, McWilliams-Koeppen HP, Acero L, Weber A, Blinder V, Mably A, Bunk S, Hermann C, Farrell MA, Ehrlich HJ, Schwarz HP, Walsh DM, Solomon A, O'Nuallain B. Human anti-Aß IgGs target conformational epitopes on synthetic dimer assemblies and the AD brain-derived peptide. PLoS One. 2012; 7(11):e50317. PMID: 23209707.
    Citations: 2     Fields:    Translation:HumansCells
  63. Borlikova GG, Trejo M, Mably AJ, Mc Donald JM, Sala Frigerio C, Regan CM, Murphy KJ, Masliah E, Walsh DM. Alzheimer brain-derived amyloid ß-protein impairs synaptic remodeling and memory consolidation. Neurobiol Aging. 2013 May; 34(5):1315-27. PMID: 23182244.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  64. Moro ML, Giaccone G, Lombardi R, Indaco A, Uggetti A, Morbin M, Saccucci S, Di Fede G, Catania M, Walsh DM, Demarchi A, Rozemuller A, Bogdanovic N, Bugiani O, Ghetti B, Tagliavini F. APP mutations in the Aß coding region are associated with abundant cerebral deposition of Aß38. Acta Neuropathol. 2012 Dec; 124(6):809-21. PMID: 23143229.
    Citations: 17     Fields:    Translation:Humans
  65. Kim YY, Williams D, Meldrum FC, Walsh D. Simple photosystem II water oxidation centre analogues in visible light oxygen and H+ generation. Small. 2013 Jan 14; 9(1):61-6. PMID: 23038668.
    Citations:    Fields:    Translation:Cells
  66. Cukalevski R, Boland B, Frohm B, Thulin E, Walsh D, Linse S. Role of aromatic side chains in amyloid ß-protein aggregation. ACS Chem Neurosci. 2012 Dec 19; 3(12):1008-16. PMID: 23259036.
    Citations: 25     Fields:    Translation:Cells
  67. Nicholson AM, Wold LA, Walsh DM, Ferreira A. ß-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons. Mol Med. 2012 Mar 27; 18:178-85. PMID: 22160219.
    Citations: 5     Fields:    Translation:AnimalsCells
  68. McDonald JM, Cairns NJ, Taylor-Reinwald L, Holtzman D, Walsh DM. The levels of water-soluble and triton-soluble Aß are increased in Alzheimer's disease brain. Brain Res. 2012 Apr 23; 1450:138-47. PMID: 22440675.
    Citations: 32     Fields:    Translation:Humans
  69. Walsh DM, Teplow DB. Alzheimer's disease and the amyloid ß-protein. Prog Mol Biol Transl Sci. 2012; 107:101-24. PMID: 22482449.
    Citations: 55     Fields:    Translation:HumansCells
  70. Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, Frank RF, Reif B, Günther S, Walsh DM, Wanker EE. Small-molecule conversion of toxic oligomers to nontoxic ß-sheet-rich amyloid fibrils. Nat Chem Biol. 2011 Nov 20; 8(1):93-101. PMID: 22101602.
    Citations: 159     Fields:    Translation:HumansCells
  71. O'Nuallain B, Klyubin I, Mc Donald JM, Foster JS, Welzel A, Barry A, Dykoski RK, Cleary JP, Gebbink MF, Rowan MJ, Walsh DM. A monoclonal antibody against synthetic Aß dimer assemblies neutralizes brain-derived synaptic plasticity-disrupting Aß. J Neurochem. 2011 Oct; 119(1):189-201. PMID: 21781116.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  72. Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J. Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites. Nat Commun. 2011 Jun 07; 2:336. PMID: 21654636; PMCID: PMC3156817.
    Citations: 153     Fields:    Translation:HumansAnimalsCells
  73. Barry AE, Klyubin I, Mc Donald JM, Mably AJ, Farrell MA, Scott M, Walsh DM, Rowan MJ. Alzheimer's disease brain-derived amyloid-ß-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. J Neurosci. 2011 May 18; 31(20):7259-63. PMID: 21593310.
    Citations: 139     Fields:    Translation:HumansAnimals
  74. Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K, Heneka MT, Walsh DM, Zweckstetter M, Walter J. Extracellular phosphorylation of the amyloid ß-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO J. 2011 Jun 01; 30(11):2255-65. PMID: 21527912.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  75. Jin M, Shepardson N, Yang T, Chen G, Walsh D, Selkoe DJ. Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A. 2011 Apr 05; 108(14):5819-24. PMID: 21421841.
    Citations: 389     Fields:    Translation:HumansAnimalsCells
  76. Shankar GM, Welzel AT, McDonald JM, Selkoe DJ, Walsh DM. Isolation of low-n amyloid ß-protein oligomers from cultured cells, CSF, and brain. Methods Mol Biol. 2011; 670:33-44. PMID: 20967581.
    Citations: 35     Fields:    Translation:HumansCells
  77. O'Nuallain B, Freir DB, Nicoll AJ, Risse E, Ferguson N, Herron CE, Collinge J, Walsh DM. Amyloid beta-protein dimers rapidly form stable synaptotoxic protofibrils. J Neurosci. 2010 Oct 27; 30(43):14411-9. PMID: 20980598; PMCID: PMC2987723.
    Citations: 116     Fields:    Translation:AnimalsCells
  78. Welzel AT, Walsh DM. Aberrant protein structure and diseases of the brain. Ir J Med Sci. 2011 Mar; 180(1):15-22. PMID: 20960238.
    Citations: 2     Fields:    Translation:HumansCells
  79. Boland B, Smith DA, Mooney D, Jung SS, Walsh DM, Platt FM. Macroautophagy is not directly involved in the metabolism of amyloid precursor protein. J Biol Chem. 2010 Nov 26; 285(48):37415-26. PMID: 20864542.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  80. Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain. 2010 May; 133(Pt 5):1328-41. PMID: 20403962; PMCID: PMC2859152.
    Citations: 124     Fields:    Translation:HumansCells
  81. Sala Frigerio C, Fadeeva JV, Minogue AM, Citron M, Van Leuven F, Staufenbiel M, Paganetti P, Selkoe DJ, Walsh DM. beta-Secretase cleavage is not required for generation of the intracellular C-terminal domain of the amyloid precursor family of proteins. FEBS J. 2010 Mar; 277(6):1503-18. PMID: 20163459.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  82. Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM. Aß oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiol Aging. 2011 Dec; 32(12):2211-8. PMID: 20097446.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  83. Reed MN, Hofmeister JJ, Jungbauer L, Welzel AT, Yu C, Sherman MA, Lesné S, LaDu MJ, Walsh DM, Ashe KH, Cleary JP. Cognitive effects of cell-derived and synthetically derived Aß oligomers. Neurobiol Aging. 2011 Oct; 32(10):1784-94. PMID: 20031278.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  84. Sala Frigerio C, Kukar TL, Fauq A, Engel PC, Golde TE, Walsh DM. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1. Biochemistry. 2009 Nov 24; 48(46):10894-904. PMID: 19821615.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  85. Shankar GM, Walsh DM. Alzheimer's disease: synaptic dysfunction and Abeta. Mol Neurodegener. 2009 Nov 23; 4:48. PMID: 19930651.
    Citations: 205     Fields:    
  86. Hellstrand E, Boland B, Walsh DM, Linse S. Amyloid ß-protein aggregation produces highly reproducible kinetic data and occurs by a two-phase process. ACS Chem Neurosci. 2010 Jan 20; 1(1):13-8. PMID: 22778803.
    Citations: 136     Fields:    Translation:Cells
  87. Hampel H, Shen Y, Walsh DM, Aisen P, Shaw LM, Zetterberg H, Trojanowski JQ, Blennow K. Biological markers of amyloid beta-related mechanisms in Alzheimer's disease. Exp Neurol. 2010 Jun; 223(2):334-46. PMID: 19815015.
    Citations: 74     Fields:    Translation:Humans
  88. Shankar GM, Leissring MA, Adame A, Sun X, Spooner E, Masliah E, Selkoe DJ, Lemere CA, Walsh DM. Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Abeta assembly forms throughout life. Neurobiol Dis. 2009 Nov; 36(2):293-302. PMID: 19660551.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  89. Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D. Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron. 2009 Jun 25; 62(6):788-801. PMID: 19555648.
    Citations: 444     Fields:    Translation:HumansAnimalsCells
  90. Walsh DM, Thulin E, Minogue AM, Gustavsson N, Pang E, Teplow DB, Linse S. A facile method for expression and purification of the Alzheimer's disease-associated amyloid beta-peptide. FEBS J. 2009 Mar; 276(5):1266-81. PMID: 19175671.
    Citations: 123     Fields:    Translation:AnimalsCells
  91. Xia W, Yang T, Shankar G, Smith IM, Shen Y, Walsh DM, Selkoe DJ. A specific enzyme-linked immunosorbent assay for measuring beta-amyloid protein oligomers in human plasma and brain tissue of patients with Alzheimer disease. Arch Neurol. 2009 Feb; 66(2):190-9. PMID: 19204155; PMCID: PMC3618974.
    Citations: 92     Fields:    Translation:HumansCells
  92. Minogue AM, Stubbs AK, Frigerio CS, Boland B, Fadeeva JV, Tang J, Selkoe DJ, Walsh DM. gamma-secretase processing of APLP1 leads to the production of a p3-like peptide that does not aggregate and is not toxic to neurons. Brain Res. 2009 Mar 25; 1262:89-99. PMID: 19401174.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  93. Green DW, Bolland BJ, Kanczler JM, Lanham SA, Walsh D, Mann S, Oreffo RO. Augmentation of skeletal tissue formation in impaction bone grafting using vaterite microsphere biocomposites. Biomaterials. 2009 Apr; 30(10):1918-27. PMID: 19135716.
    Citations: 7     Fields:    Translation:HumansCells
  94. O'Shea SD, Smith IM, McCabe OM, Cronin MM, Walsh DM, O'Connor WT. Intracerebroventricular Administration of Amyloid ß-protein Oligomers Selectively Increases Dorsal Hippocampal Dialysate Glutamate Levels in the Awake Rat. Sensors (Basel). 2008 Nov 19; 8(11):7428-7437. PMID: 27873937.
    Citations: 13     Fields:    
  95. Cabaleiro-Lago C, Quinlan-Pluck F, Lynch I, Lindman S, Minogue AM, Thulin E, Walsh DM, Dawson KA, Linse S. Inhibition of amyloid beta protein fibrillation by polymeric nanoparticles. J Am Chem Soc. 2008 Nov 19; 130(46):15437-43. PMID: 18954050.
    Citations: 102     Fields:    Translation:Cells
  96. Hu NW, Smith IM, Walsh DM, Rowan MJ. Soluble amyloid-beta peptides potently disrupt hippocampal synaptic plasticity in the absence of cerebrovascular dysfunction in vivo. Brain. 2008 Sep; 131(Pt 9):2414-24. PMID: 18678563.
    Citations: 36     Fields:    Translation:AnimalsCells
  97. Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM. Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Mol Med. 2008 Jul-Aug; 14(7-8):451-64. PMID: 18368143.
    Citations: 178     Fields:    Translation:Humans
  98. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug; 14(8):837-42. PMID: 18568035.
    Citations: 1705     Fields:    Translation:HumansAnimalsCells
  99. Betts V, Leissring MA, Dolios G, Wang R, Selkoe DJ, Walsh DM. Aggregation and catabolism of disease-associated intra-Abeta mutations: reduced proteolysis of AbetaA21G by neprilysin. Neurobiol Dis. 2008 Sep; 31(3):442-50. PMID: 18602473.
    Citations: 47     Fields:    Translation:HumansCells
  100. Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Substrate-targeting gamma-secretase modulators. Nature. 2008 Jun 12; 453(7197):925-9. PMID: 18548070.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  101. Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, Selkoe DJ, Anwyl R, Walsh DM, Rowan MJ. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci. 2008 Apr 16; 28(16):4231-7. PMID: 18417702.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  102. McDonough SM, Liddle SD, Hunter R, Walsh DM, Glasgow P, Gormley G, Hurley D, Delitto A, Park J, Bradbury I, Baxter GD. Exercise and manual auricular acupuncture: a pilot assessor-blind randomised controlled trial. (The acupuncture and personalised exercise programme (APEP) trial). BMC Musculoskelet Disord. 2008 Mar 06; 9:31. PMID: 18325114.
    Citations: 8     Fields:    Translation:Humans
  103. Farris W, Schütz SG, Cirrito JR, Shankar GM, Sun X, George A, Leissring MA, Walsh DM, Qiu WQ, Holtzman DM, Selkoe DJ. Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol. 2007 Jul; 171(1):241-51. PMID: 17591969; PMCID: PMC1941603.
    Citations: 73     Fields:    Translation:HumansAnimals
  104. Walsh DM, Minogue AM, Sala Frigerio C, Fadeeva JV, Wasco W, Selkoe DJ. The APP family of proteins: similarities and differences. Biochem Soc Trans. 2007 Apr; 35(Pt 2):416-20. PMID: 17371289.
    Citations: 61     Fields:    Translation:HumansAnimals
  105. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14; 27(11):2866-75. PMID: 17360908; PMCID: PMC6672572.
    Citations: 751     Fields:    Translation:HumansAnimalsCells
  106. Walsh DM, Selkoe DJ. A beta oligomers - a decade of discovery. J Neurochem. 2007 Jun; 101(5):1172-84. PMID: 17286590.
    Citations: 775     Fields:    Translation:HumansCells
  107. Walsh DM, Finwall J, Touchette PE, McGregor MR, Fernandez GE, Lott IT, Sandman CA. Rapid assessment of severe cognitive impairment in individuals with developmental disabilities. J Intellect Disabil Res. 2007 Feb; 51(Pt 2):91-100. PMID: 17217473.
    Citations: 6     Fields:    Translation:Humans
  108. Townsend M, Cleary JP, Mehta T, Hofmeister J, Lesne S, O'Hare E, Walsh DM, Selkoe DJ. Orally available compound prevents deficits in memory caused by the Alzheimer amyloid-beta oligomers. Ann Neurol. 2006 Dec; 60(6):668-76. PMID: 17192927.
    Citations: 61     Fields:    Translation:Animals
  109. Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, Wetzel R, Wexler NS, Young AB, Bain L. Common threads in neurodegenerative disorders of aging. Alzheimers Dement. 2006 Oct; 2(4):322-6. PMID: 19595906.
    Citations: 3     Fields:    
  110. Meyer-Luehmann M, Coomaraswamy J, Bolmont T, Kaeser S, Schaefer C, Kilger E, Neuenschwander A, Abramowski D, Frey P, Jaton AL, Vigouret JM, Paganetti P, Walsh DM, Mathews PM, Ghiso J, Staufenbiel M, Walker LC, Jucker M. Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host. Science. 2006 Sep 22; 313(5794):1781-4. PMID: 16990547.
    Citations: 469     Fields:    Translation:HumansAnimalsCells
  111. Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol. 2006 Apr 15; 572(Pt 2):477-92. PMID: 16469784; PMCID: PMC1779683.
    Citations: 268     Fields:    Translation:AnimalsCells
  112. Walsh DM, Klyubin I, Shankar GM, Townsend M, Fadeeva JV, Betts V, Podlisny MB, Cleary JP, Ashe KH, Rowan MJ, Selkoe DJ. The role of cell-derived oligomers of Abeta in Alzheimer's disease and avenues for therapeutic intervention. Biochem Soc Trans. 2005 Nov; 33(Pt 5):1087-90. PMID: 16246051.
    Citations: 95     Fields:    Translation:Humans
  113. Klyubin I, Walsh DM, Lemere CA, Cullen WK, Shankar GM, Betts V, Spooner ET, Jiang L, Anwyl R, Selkoe DJ, Rowan MJ. Amyloid beta protein immunotherapy neutralizes Abeta oligomers that disrupt synaptic plasticity in vivo. Nat Med. 2005 May; 11(5):556-61. PMID: 15834427.
    Citations: 199     Fields:    Translation:AnimalsCellsPHPublic Health
  114. Walsh DM, Townsend M, Podlisny MB, Shankar GM, Fadeeva JV, El Agnaf O, Hartley DM, Selkoe DJ. Certain inhibitors of synthetic amyloid beta-peptide (Abeta) fibrillogenesis block oligomerization of natural Abeta and thereby rescue long-term potentiation. J Neurosci. 2005 Mar 09; 25(10):2455-62. PMID: 15758153; PMCID: PMC6725159.
    Citations: 108     Fields:    Translation:AnimalsCells
  115. Cleary JP, Walsh DM, Hofmeister JJ, Shankar GM, Kuskowski MA, Selkoe DJ, Ashe KH. Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci. 2005 Jan; 8(1):79-84. PMID: 15608634.
    Citations: 711     Fields:    Translation:HumansAnimalsCells
  116. Seabrook TJ, Bloom JK, Iglesias M, Spooner ET, Walsh DM, Lemere CA. Species-specific immune response to immunization with human versus rodent A beta peptide. Neurobiol Aging. 2004 Oct; 25(9):1141-51. PMID: 15312960.
    Citations: 11     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  117. Walsh DM, Selkoe DJ. Deciphering the molecular basis of memory failure in Alzheimer's disease. Neuron. 2004 Sep 30; 44(1):181-93. PMID: 15450169.
    Citations: 418     Fields:    Translation:HumansAnimalsCells
  118. Ye C, Walsh DM, Selkoe DJ, Hartley DM. Amyloid beta-protein induced electrophysiological changes are dependent on aggregation state: N-methyl-D-aspartate (NMDA) versus non-NMDA receptor/channel activation. Neurosci Lett. 2004 Aug 19; 366(3):320-5. PMID: 15288443.
    Citations: 29     Fields:    Translation:AnimalsCells
  119. Walsh DM, Selkoe DJ. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein Pept Lett. 2004 Jun; 11(3):213-28. PMID: 15182223.
    Citations: 154     Fields:    Translation:HumansAnimals
  120. Klyubin I, Walsh DM, Cullen WK, Fadeeva JV, Anwyl R, Selkoe DJ, Rowan MJ. Soluble Arctic amyloid beta protein inhibits hippocampal long-term potentiation in vivo. Eur J Neurosci. 2004 May; 19(10):2839-46. PMID: 15147317.
    Citations: 44     Fields:    Translation:Animals
  121. Wang Q, Walsh DM, Rowan MJ, Selkoe DJ, Anwyl R. Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. J Neurosci. 2004 Mar 31; 24(13):3370-8. PMID: 15056716; PMCID: PMC6730034.
    Citations: 198     Fields:    Translation:HumansAnimalsCells
  122. Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, Sun X, Frosch MP, Selkoe DJ. Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron. 2003 Dec 18; 40(6):1087-93. PMID: 14687544.
    Citations: 278     Fields:    Translation:HumansAnimalsCells
  123. El-Agnaf OM, Walsh DM, Allsop D. Soluble oligomers for the diagnosis of neurodegenerative diseases. Lancet Neurol. 2003 Aug; 2(8):461-2. PMID: 12878433.
    Citations: 16     Fields:    Translation:HumansAnimals
  124. Walsh DM, Fadeeva JV, LaVoie MJ, Paliga K, Eggert S, Kimberly WT, Wasco W, Selkoe DJ. gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins. Biochemistry. 2003 Jun 10; 42(22):6664-73. PMID: 12779321.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  125. Kimberly WT, Kovacs DM, Walsh D, Lashuel H, Lemere CA. The 8th International Conference on Alzheimer's Disease and Related Disorders, July 20-25, 2002, Stockholm, Sweden. Amyloid. 2003 Mar; 10(1):51-61. PMID: 12762144.
    Citations:    Fields:    Translation:HumansAnimals
  126. Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 2003 Feb 20; 37(4):583-95. PMID: 12597857.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  127. Walsh DM, Klyubin I, Fadeeva JV, Rowan MJ, Selkoe DJ. Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans. 2002 Aug; 30(4):552-7. PMID: 12196135.
    Citations: 178     Fields:    Translation:HumansCells
  128. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature. 2002 Apr 04; 416(6880):535-9. PMID: 11932745.
    Citations: 1608     Fields:    Translation:HumansAnimalsCells
  129. Walsh DM, Hartley DM, Condron MM, Selkoe DJ, Teplow DB. In vitro studies of amyloid beta-protein fibril assembly and toxicity provide clues to the aetiology of Flemish variant (Ala692-->Gly) Alzheimer's disease. Biochem J. 2001 May 01; 355(Pt 3):869-77. PMID: 11311152; PMCID: PMC1221805.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  130. Fezoui Y, Hartley DM, Walsh DM, Selkoe DJ, Osterhout JJ, Teplow DB. A de novo designed helix-turn-helix peptide forms nontoxic amyloid fibrils. Nat Struct Biol. 2000 Dec; 7(12):1095-9. PMID: 11101888.
    Citations: 35     Fields:    Translation:AnimalsCells
  131. Walsh DM, Tseng BP, Rydel RE, Podlisny MB, Selkoe DJ. The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain. Biochemistry. 2000 Sep 05; 39(35):10831-9. PMID: 10978169.
    Citations: 163     Fields:    Translation:HumansAnimalsCells
  132. Fezoui Y, Hartley DM, Harper JD, Khurana R, Walsh DM, Condron MM, Selkoe DJ, Lansbury PT, Fink AL, Teplow DB. An improved method of preparing the amyloid beta-protein for fibrillogenesis and neurotoxicity experiments. Amyloid. 2000 Sep; 7(3):166-78. PMID: 11019857.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  133. Barlas P, Craig JA, Robinson J, Walsh DM, Baxter GD, Allen JM. Managing delayed-onset muscle soreness: lack of effect of selected oral systemic analgesics. Arch Phys Med Rehabil. 2000 Jul; 81(7):966-72. PMID: 10896014.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  134. Hartley DM, Walsh DM, Ye CP, Diehl T, Vasquez S, Vassilev PM, Teplow DB, Selkoe DJ. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci. 1999 Oct 15; 19(20):8876-84. PMID: 10516307; PMCID: PMC6782787.
    Citations: 282     Fields:    Translation:AnimalsCells
  135. Walsh DM, Hartley DM, Kusumoto Y, Fezoui Y, Condron MM, Lomakin A, Benedek GB, Selkoe DJ, Teplow DB. Amyloid beta-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates. J Biol Chem. 1999 Sep 03; 274(36):25945-52. PMID: 10464339.
    Citations: 306     Fields:    Translation:HumansCells
  136. Craig JA, Bradley J, Walsh DM, Baxter GD, Allen JM. Delayed onset muscle soreness: lack of effect of therapeutic ultrasound in humans. Arch Phys Med Rehabil. 1999 Mar; 80(3):318-23. PMID: 10084441.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  137. Craig JA, Barron J, Walsh DM, Baxter GD. Lack of effect of combined low intensity laser therapy/phototherapy (CLILT) on delayed onset muscle soreness in humans. Lasers Surg Med. 1999; 24(3):223-30. PMID: 10229153.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  138. Qiu WQ, Walsh DM, Ye Z, Vekrellis K, Zhang J, Podlisny MB, Rosner MR, Safavi A, Hersh LB, Selkoe DJ. Insulin-degrading enzyme regulates extracellular levels of amyloid beta-protein by degradation. J Biol Chem. 1998 Dec 04; 273(49):32730-8. PMID: 9830016.
    Citations: 289     Fields:    Translation:HumansAnimalsCells
  139. El-Agnaf OM, Guthrie DJ, Walsh DM, Irvine GB. The influence of the central region containing residues 19-25 on the aggregation properties and secondary structure of Alzheimer's beta-amyloid peptide. Eur J Biochem. 1998 Sep 15; 256(3):560-9. PMID: 9780232.
    Citations: 6     Fields:    Translation:HumansCells
  140. Podlisny MB, Walsh DM, Amarante P, Ostaszewski BL, Stimson ER, Maggio JE, Teplow DB, Selkoe DJ. Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry. 1998 Mar 17; 37(11):3602-11. PMID: 9521679.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  141. Walsh DM, Lomakin A, Benedek GB, Condron MM, Teplow DB. Amyloid beta-protein fibrillogenesis. Detection of a protofibrillar intermediate. J Biol Chem. 1997 Aug 29; 272(35):22364-72. PMID: 9268388.
    Citations: 305     Fields:    Translation:Humans
  142. el-Agnaf OM, Irvine GB, Guthrie DJ, Walsh DM. Properties of some peptides related to amyloid beta-peptide. Biochem Soc Trans. 1996 Feb; 24(1):59S. PMID: 8674733.
    Citations:    Fields:    Translation:HumansCells
  143. Clements A, Allsop D, Walsh DM, Williams CH. Aggregation and metal-binding properties of mutant forms of the amyloid A beta peptide of Alzheimer's disease. J Neurochem. 1996 Feb; 66(2):740-7. PMID: 8592147.
    Citations: 36     Fields:    Translation:HumansCells
  144. Beresford IJ, Sheldrick RL, Ball DI, Turpin MP, Walsh DM, Hawcock AB, Coleman RA, Hagan RM, Tyers MB. GR159897, a potent non-peptide antagonist at tachykinin NK2 receptors. Eur J Pharmacol. 1995 Jan 16; 272(2-3):241-8. PMID: 7713168.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  145. Stables JM, Beresford IJ, Arkinstall S, Ireland SJ, Walsh DM, Seale PW, Ward P, Hagan RM. GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors. Neuropeptides. 1994 Dec; 27(6):333-41. PMID: 7534879.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  146. Walsh DM, Williams CH, Kennedy HE, Allsop D. An investigation into the proteolytic cleavage of Alzheimer amyloid precursor protein in PC-12 cells. Biochem Soc Trans. 1994 Feb; 22(1):14S. PMID: 8206210.
    Citations:    Fields:    Translation:AnimalsCells
  147. Clements A, Walsh DM, Williams CH, Allsop D. Aggregation of Alzheimer's peptides. Biochem Soc Trans. 1994 Feb; 22(1):16S. PMID: 8206215.
    Citations:    Fields:    Translation:Cells
  148. Walsh DM, Williams CH, Kennedy HE, Allsop D, Murphy G. Gelatinase A not alpha-secretase? Nature. 1994 Jan 06; 367(6458):27-8. PMID: 7906388.
    Citations: 2     Fields:    Translation:AnimalsCells
  149. Clements A, Walsh DM, Williams CH, Allsop D. Effects of the mutations Glu22 to Gln and Ala21 to Gly on the aggregation of a synthetic fragment of the Alzheimer's amyloid beta/A4 peptide. Neurosci Lett. 1993 Oct 14; 161(1):17-20. PMID: 7902973.
    Citations: 14     Fields:    Translation:HumansCells
  150. Williams CH, Yamamoto T, Walsh DM, Allsop D. Endopeptidase converts N-1-(R,S)carboxy-3-phenylpropyl-Ala-Ala-Phe-p-carboxyanilide into a potent inhibitor of angiotensin-converting enzyme. Biochem J. 1993 Sep 15; 294 ( Pt 3):681-4. PMID: 8379924; PMCID: PMC1134516.
    Citations: 4     Fields:    Translation:AnimalsCells
  151. Elliott PJ, Walsh DM, Close SP. Dopamine D1 and D2 receptor interactions in the MPTP-treated marmoset. Neurosci Lett. 1992 Aug 03; 142(1):1-4. PMID: 1357609.
    Citations: 5     Fields:    Translation:Animals
  152. Walsh DM, Kennedy S, Blanchflower WJ, Kennedy DG. The effect of vitamin E and/or selenium depletion on tissue peroxidation and peroxidisability in ruminant cattle. Biochem Soc Trans. 1991 Feb; 19(1):61S. PMID: 2037192.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.