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Last Name

profileBernardo Luis Sabatini, Ph.D., M.D.

TitleAlice and Rodman W. Moorhead III Professor of Neurobiology
InstitutionHarvard Medical School
AddressHarvard Medical School
220 Longwood Ave
Boston MA 02115
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Other Positions
TitleInterim Head of the Department of Neurobiology
InstitutionHarvard Medical School

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DK114834     (SABATINI, BERNARDO L)Sep 1, 2017 - Jul 31, 2021
Central circuitry controlling micturition
Role: Principal Investigator

R01NS103226     (SABATINI, BERNARDO L)Jul 1, 2017 - Apr 30, 2022
Structure and function of the mouse parafasicular and entopeduncular nuclei
Role: Principal Investigator

U01NS094190     (SABATINI, BERNARDO L)Sep 30, 2015 - Aug 31, 2018
Novel optrodes for large-scale electrophysiology and site-specific stimulation
Role: Co-Principal Investigator

U01NS094191     (SABATINI, BERNARDO L)Sep 22, 2015 - Jun 30, 2018
Lagging or Leading? Linking Substantia Nigra Activity to Spontaneous Motor Sequences
Role: Co-Principal Investigator

R01MH100568     (SABATINI, BERNARDO L)Sep 1, 2013 - Aug 31, 2018
Peptide Modulation of Striatal Patch and Matrix Subdivisions
Role: Principal Investigator
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Bernardo Sabatini Lab - Mouse strains (2)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Jackman SL, Chen CH, Chettih SN, Neufeld SQ, Drew IR, Agba CK, Flaquer I, Stefano AN, Kennedy TJ, Belinsky JE, Roberston K, Beron CC, Sabatini BL, Harvey CD, Regehr WG. Silk Fibroin Films Facilitate Single-Step Targeted Expression of Optogenetic Proteins. Cell Rep. 2018 Mar 20; 22(12):3351-3361. PMID: 29562189.
    View in: PubMed
  2. Pisanello M, Pisano F, Sileo L, Maglie E, Bellistri E, Spagnolo B, Mandelbaum G, Sabatini BL, De Vittorio M, Pisanello F. Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers. Sci Rep. 2018 Mar 13; 8(1):4467. PMID: 29535413.
    View in: PubMed
  3. Piatkevich KD, Jung EE, Straub C, Linghu C, Park D, Suk HJ, Hochbaum DR, Goodwin D, Pnevmatikakis E, Pak N, Kawashima T, Yang CT, Rhoades JL, Shemesh O, Asano S, Yoon YG, Freifeld L, Saulnier JL, Riegler C, Engert F, Hughes T, Drobizhev M, Szabo B, Ahrens MB, Flavell SW, Sabatini BL, Boyden ES. Publisher Correction: A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters. Nat Chem Biol. 2018 Mar 08. PMID: 29520042.
    View in: PubMed
  4. Piatkevich KD, Jung EE, Straub C, Linghu C, Park D, Suk HJ, Hochbaum DR, Goodwin D, Pnevmatikakis E, Pak N, Kawashima T, Yang CT, Rhoades JL, Shemesh O, Asano S, Yoon YG, Freifeld L, Saulnier JL, Riegler C, Engert F, Hughes T, Drobizhev M, Szabo B, Ahrens MB, Flavell SW, Sabatini BL, Boyden ES. A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters. Nat Chem Biol. 2018 Apr; 14(4):352-360. PMID: 29483642.
    View in: PubMed
  5. Zhou P, Resendez SL, Rodriguez-Romaguera J, Jimenez JC, Neufeld SQ, Giovannucci A, Friedrich J, Pnevmatikakis EA, Stuber GD, Hen R, Kheirbek MA, Sabatini BL, Kass RE, Paninski L. Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data. Elife. 2018 Feb 22; 7. PMID: 29469809.
    View in: PubMed
  6. Banghart MR, He XJ, Sabatini BL. A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors. ACS Chem Neurosci. 2017 Dec 27. PMID: 29266926.
    View in: PubMed
  7. Hrvatin S, Hochbaum DR, Nagy MA, Cicconet M, Robertson K, Cheadle L, Zilionis R, Ratner A, Borges-Monroy R, Klein AM, Sabatini BL, Greenberg ME. Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat Neurosci. 2018 Jan; 21(1):120-129. PMID: 29230054.
    View in: PubMed
  8. Chen Y, Granger AJ, Tran T, Saulnier JL, Kirkwood A, Sabatini BL. Endogenous Gaq-Coupled Neuromodulator Receptors Activate Protein Kinase A. Neuron. 2017 Dec 06; 96(5):1070-1083.e5. PMID: 29154125.
    View in: PubMed
  9. Pisanello F, Mandelbaum G, Pisanello M, Oldenburg IA, Sileo L, Markowitz JE, Peterson RE, Della Patria A, Haynes TM, Emara MS, Spagnolo B, Datta SR, De Vittorio M, Sabatini BL. Dynamic illumination of spatially restricted or large brain volumes via a single tapered optical fiber. Nat Neurosci. 2017 Aug; 20(8):1180-1188. PMID: 28628101.
    View in: PubMed
  10. Granger AJ, Wallace ML, Sabatini BL. Multi-transmitter neurons in the mammalian central nervous system. Curr Opin Neurobiol. 2017 Aug; 45:85-91. PMID: 28500992.
    View in: PubMed
  11. Wallace ML, Saunders A, Huang KW, Philson AC, Goldman M, Macosko EZ, McCarroll SA, Sabatini BL. Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia. Neuron. 2017 Apr 05; 94(1):138-152.e5. PMID: 28384468.
    View in: PubMed
  12. Straub C, Saulnier JL, Bègue A, Feng DD, Huang KW, Sabatini BL. Principles of Synaptic Organization of GABAergic Interneurons in the Striatum. Neuron. 2016 Oct 05; 92(1):84-92. PMID: 27710792.
    View in: PubMed
  13. Hou XH, Hyun M, Taranda J, Huang KW, Todd E, Feng D, Atwater E, Croney D, Zeidel ML, Osten P, Sabatini BL. Central Control Circuit for Context-Dependent Micturition. Cell. 2016 Sep 22; 167(1):73-86.e12. PMID: 27662084.
    View in: PubMed
  14. Kong D, Dagon Y, Campbell JN, Guo Y, Yang Z, Yi X, Aryal P, Wellenstein K, Kahn BB, Sabatini BL, Lowell BB. A Postsynaptic AMPK?p21-Activated Kinase Pathway Drives Fasting-Induced Synaptic Plasticity in AgRP Neurons. Neuron. 2016 07 06; 91(1):25-33. PMID: 27321921.
    View in: PubMed
  15. Gross GG, Straub C, Perez-Sanchez J, Dempsey WP, Junge JA, Roberts RW, Trinh le A, Fraser SE, De Koninck Y, De Koninck P, Sabatini BL, Arnold DB. An E3-ligase-based method for ablating inhibitory synapses. Nat Methods. 2016 08; 13(8):673-8. PMID: 27271196.
    View in: PubMed
  16. Kantevari S, Passlick S, Kwon HB, Richers MT, Sabatini BL, Ellis-Davies GC. Development of Anionically Decorated Caged Neurotransmitters: In Vitro Comparison of 7-Nitroindolinyl- and 2-(p-Phenyl-o-nitrophenyl)propyl-Based Photochemical Probes. Chembiochem. 2016 05 17; 17(10):953-61. PMID: 26929152; PMCID: PMC4870097.
  17. Peixoto RT, Wang W, Croney DM, Kozorovitskiy Y, Sabatini BL. Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B(-/-) mice. Nat Neurosci. 2016 05; 19(5):716-724. PMID: 26928064; PMCID: PMC4846490.
  18. Chen Y, Saulnier JL, Yellen G, Sabatini BL. Corrigendum: A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging. Front Pharmacol. 2016; 7:46. PMID: 26941646; PMCID: PMC4766420.
  19. Saunders A, Huang KW, Sabatini BL. Globus Pallidus Externus Neurons Expressing parvalbumin Interconnect the Subthalamic Nucleus and Striatal Interneurons. PLoS One. 2016; 11(2):e0149798. PMID: 26905595; PMCID: PMC4764347.
  20. Tritsch NX, Granger AJ, Sabatini BL. Mechanisms and functions of GABA co-release. Nat Rev Neurosci. 2016 Mar; 17(3):139-45. PMID: 26865019.
    View in: PubMed
  21. Banghart MR, Neufeld SQ, Wong NC, Sabatini BL. Enkephalin Disinhibits Mu Opioid Receptor-Rich Striatal Patches via Delta Opioid Receptors. Neuron. 2015 Dec 16; 88(6):1227-39. PMID: 26671460; PMCID: PMC4698909 [Available on 12/16/16].
  22. Kozorovitskiy Y, Peixoto R, Wang W, Saunders A, Sabatini BL. Neuromodulation of excitatory synaptogenesis in striatal development. Elife. 2015 Nov 09; 4. PMID: 26551563; PMCID: PMC4716836.
  23. Pisanello M, Della Patria A, Sileo L, Sabatini BL, De Vittorio M, Pisanello F. Modal demultiplexing properties of tapered and nanostructured optical fibers for in vivo optogenetic control of neural activity. Biomed Opt Express. 2015 Oct 01; 6(10):4014-26. PMID: 26504650; PMCID: PMC4605059.
  24. Granger AJ, Mulder N, Saunders A, Sabatini BL. Cotransmission of acetylcholine and GABA. Neuropharmacology. 2016 Jan; 100:40-6. PMID: 26220313; PMCID: PMC4584188 [Available on 01/01/17].
  25. Saunders A, Sabatini BL. Cre Activated and Inactivated Recombinant Adeno-Associated Viral Vectors for Neuronal Anatomical Tracing or Activity Manipulation. Curr Protoc Neurosci. 2015 Jul 01; 72:1.24.1-15. PMID: 26131660; PMCID: PMC4545963.
  26. Oldenburg IA, Sabatini BL. Antagonistic but Not Symmetric Regulation of Primary Motor Cortex by Basal Ganglia Direct and Indirect Pathways. Neuron. 2015 Jun 03; 86(5):1174-81. PMID: 26050037; PMCID: PMC4458709.
  27. Saunders A, Oldenburg IA, Berezovskii VK, Johnson CA, Kingery ND, Elliott HL, Xie T, Gerfen CR, Sabatini BL. A direct GABAergic output from the basal ganglia to frontal cortex. Nature. 2015 May 07; 521(7550):85-9. PMID: 25739505; PMCID: PMC4425585.
  28. Saunders A, Granger AJ, Sabatini BL. Corelease of acetylcholine and GABA from cholinergic forebrain neurons. Elife. 2015 Feb 27; 4. PMID: 25723967; PMCID: PMC4371381.
  29. Wang S, Tsun ZY, Wolfson RL, Shen K, Wyant GA, Plovanich ME, Yuan ED, Jones TD, Chantranupong L, Comb W, Wang T, Bar-Peled L, Zoncu R, Straub C, Kim C, Park J, Sabatini BL, Sabatini DM. Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1. Science. 2015 Jan 09; 347(6218):188-94. PMID: 25567906; PMCID: PMC4295826.
  30. Straub C, Granger AJ, Saulnier JL, Sabatini BL. CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons. PLoS One. 2014; 9(8):e105584. PMID: 25140704; PMCID: PMC4139396.
  31. Khibnik LA, Tritsch NX, Sabatini BL. A direct projection from mouse primary visual cortex to dorsomedial striatum. PLoS One. 2014; 9(8):e104501. PMID: 25141172; PMCID: PMC4139305.
  32. Hochbaum DR, Zhao Y, Farhi SL, Klapoetke N, Werley CA, Kapoor V, Zou P, Kralj JM, Maclaurin D, Smedemark-Margulies N, Saulnier JL, Boulting GL, Straub C, Cho YK, Melkonian M, Wong GK, Harrison DJ, Murthy VN, Sabatini BL, Boyden ES, Campbell RE, Cohen AE. All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins. Nat Methods. 2014 Aug; 11(8):825-33. PMID: 24952910; PMCID: PMC4117813.
  33. Straub C, Tritsch NX, Hagan NA, Gu C, Sabatini BL. Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. J Neurosci. 2014 Jun 18; 34(25):8557-69. PMID: 24948810; PMCID: PMC4061393.
  34. Pisanello F, Sileo L, Oldenburg IA, Pisanello M, Martiradonna L, Assad JA, Sabatini BL, De Vittorio M. Multipoint-emitting optical fibers for spatially addressable in vivo optogenetics. Neuron. 2014 Jun 18; 82(6):1245-54. PMID: 24881834; PMCID: PMC4256382.
  35. Takasaki K, Sabatini BL. Super-resolution 2-photon microscopy reveals that the morphology of each dendritic spine correlates with diffusive but not synaptic properties. Front Neuroanat. 2014; 8:29. PMID: 24847215; PMCID: PMC4019874.
  36. Tritsch NX, Oh WJ, Gu C, Sabatini BL. Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. Elife. 2014 Apr 24; 3:e01936. PMID: 24843012; PMCID: PMC4001323.
  37. Straub C, Sabatini BL. How to grow a synapse. Neuron. 2014 Apr 16; 82(2):256-7. PMID: 24742454.
    View in: PubMed
  38. Chen Y, Saulnier JL, Yellen G, Sabatini BL. A PKA activity sensor for quantitative analysis of endogenous GPCR signaling via 2-photon FRET-FLIM imaging. Front Pharmacol. 2014; 5:56. PMID: 24765076; PMCID: PMC3980114.
  39. Nieland TJ, Logan DJ, Saulnier J, Lam D, Johnson C, Root DE, Carpenter AE, Sabatini BL. High content image analysis identifies novel regulators of synaptogenesis in a high-throughput RNAi screen of primary neurons. PLoS One. 2014; 9(3):e91744. PMID: 24633176; PMCID: PMC3954765.
  40. Murphy JA, Stein IS, Lau CG, Peixoto RT, Aman TK, Kaneko N, Aromolaran K, Saulnier JL, Popescu GK, Sabatini BL, Hell JW, Zukin RS. Phosphorylation of Ser1166 on GluN2B by PKA is critical to synaptic NMDA receptor function and Ca2+ signaling in spines. J Neurosci. 2014 Jan 15; 34(3):869-79. PMID: 24431445; PMCID: PMC3891964.
  41. Olson JP, Banghart MR, Sabatini BL, Ellis-Davies GC. Spectral evolution of a photochemical protecting group for orthogonal two-color uncaging with visible light. J Am Chem Soc. 2013 Oct 23; 135(42):15948-54. PMID: 24117060; PMCID: PMC4097017.
  42. Bateup HS, Denefrio CL, Johnson CA, Saulnier JL, Sabatini BL. Temporal dynamics of a homeostatic pathway controlling neural network activity. Front Mol Neurosci. 2013; 6:28. PMID: 24065881; PMCID: PMC3776619.
  43. Banghart MR, Williams JT, Shah RC, Lavis LD, Sabatini BL. Caged naloxone reveals opioid signaling deactivation kinetics. Mol Pharmacol. 2013 Nov; 84(5):687-95. PMID: 23960100; PMCID: PMC3807075.
  44. Tang JC, Szikra T, Kozorovitskiy Y, Teixiera M, Sabatini BL, Roska B, Cepko CL. A nanobody-based system using fluorescent proteins as scaffolds for cell-specific gene manipulation. Cell. 2013 Aug 15; 154(4):928-39. PMID: 23953120; PMCID: PMC4096992.
  45. Gross GG, Junge JA, Mora RJ, Kwon HB, Olson CA, Takahashi TT, Liman ER, Ellis-Davies GC, McGee AW, Sabatini BL, Roberts RW, Arnold DB. Recombinant probes for visualizing endogenous synaptic proteins in living neurons. Neuron. 2013 Jun 19; 78(6):971-85. PMID: 23791193; PMCID: PMC3779638.
  46. Bateup HS, Johnson CA, Denefrio CL, Saulnier JL, Kornacker K, Sabatini BL. Excitatory/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis. Neuron. 2013 May 08; 78(3):510-22. PMID: 23664616; PMCID: PMC3690324.
  47. Olson JP, Kwon HB, Takasaki KT, Chiu CQ, Higley MJ, Sabatini BL, Ellis-Davies GC. Optically selective two-photon uncaging of glutamate at 900 nm. J Am Chem Soc. 2013 Apr 24; 135(16):5954-7. PMID: 23577752; PMCID: PMC4079120.
  48. Takasaki KT, Ding JB, Sabatini BL. Live-cell superresolution imaging by pulsed STED two-photon excitation microscopy. Biophys J. 2013 Feb 19; 104(4):770-7. PMID: 23442955; PMCID: PMC3576532.
  49. Beier KT, Saunders AB, Oldenburg IA, Sabatini BL, Cepko CL. Vesicular stomatitis virus with the rabies virus glycoprotein directs retrograde transsynaptic transport among neurons in vivo. Front Neural Circuits. 2013; 7:11. PMID: 23403489; PMCID: PMC3566411.
  50. Kwon HB, Kozorovitskiy Y, Oh WJ, Peixoto RT, Akhtar N, Saulnier JL, Gu C, Sabatini BL. Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nat Neurosci. 2012 Dec; 15(12):1667-74. PMID: 23143522; PMCID: PMC3536444.
  51. Peixoto RT, Kunz PA, Kwon H, Mabb AM, Sabatini BL, Philpot BD, Ehlers MD. Transsynaptic signaling by activity-dependent cleavage of neuroligin-1. Neuron. 2012 Oct 18; 76(2):396-409. PMID: 23083741; PMCID: PMC3783515.
  52. Tritsch NX, Sabatini BL. Dopaminergic modulation of synaptic transmission in cortex and striatum. Neuron. 2012 Oct 04; 76(1):33-50. PMID: 23040805; PMCID: PMC4386589.
  53. Tritsch NX, Ding JB, Sabatini BL. Dopaminergic neurons inhibit striatal output through non-canonical release of GABA. Nature. 2012 Oct 11; 490(7419):262-6. PMID: 23034651; PMCID: PMC3944587.
  54. Carter BC, Giessel AJ, Sabatini BL, Bean BP. Transient sodium current at subthreshold voltages: activation by EPSP waveforms. Neuron. 2012 Sep 20; 75(6):1081-93. PMID: 22998875; PMCID: PMC3460524.
  55. Saunders A, Johnson CA, Sabatini BL. Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons. Front Neural Circuits. 2012; 6:47. PMID: 22866029; PMCID: PMC3406316.
  56. Kozorovitskiy Y, Saunders A, Johnson CA, Lowell BB, Sabatini BL. Recurrent network activity drives striatal synaptogenesis. Nature. 2012 May 13; 485(7400):646-50. PMID: 22660328; PMCID: PMC3367801.
  57. Sheng M, Sabatini BL, Südhof TC. Synapses and Alzheimer's disease. Cold Spring Harb Perspect Biol. 2012 May 01; 4(5). PMID: 22491782; PMCID: PMC3331702.
  58. Higley MJ, Sabatini BL. Calcium signaling in dendritic spines. Cold Spring Harb Perspect Biol. 2012 Apr 01; 4(4):a005686. PMID: 22338091; PMCID: PMC3312680.
  59. Chen Y, Sabatini BL. Signaling in dendritic spines and spine microdomains. Curr Opin Neurobiol. 2012 Jun; 22(3):389-96. PMID: 22459689; PMCID: PMC3391315.
  60. Liu T, Kong D, Shah BP, Ye C, Koda S, Saunders A, Ding JB, Yang Z, Sabatini BL, Lowell BB. Fasting activation of AgRP neurons requires NMDA receptors and involves spinogenesis and increased excitatory tone. Neuron. 2012 Feb 09; 73(3):511-22. PMID: 22325203; PMCID: PMC3278709.
  61. Banghart MR, Sabatini BL. Photoactivatable neuropeptides for spatiotemporally precise delivery of opioids in neural tissue. Neuron. 2012 Jan 26; 73(2):249-59. PMID: 22284180; PMCID: PMC3282187.
  62. Ding JB, Oh WJ, Sabatini BL, Gu C. Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum. Nat Neurosci. 2011 Dec 18; 15(2):215-23. PMID: 22179111; PMCID: PMC3267860.
  63. Sigrist SJ, Sabatini BL. Optical super-resolution microscopy in neurobiology. Curr Opin Neurobiol. 2012 Feb; 22(1):86-93. PMID: 22051692.
    View in: PubMed
  64. Beier KT, Saunders A, Oldenburg IA, Miyamichi K, Akhtar N, Luo L, Whelan SP, Sabatini B, Cepko CL. Anterograde or retrograde transsynaptic labeling of CNS neurons with vesicular stomatitis virus vectors. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15414-9. PMID: 21825165; PMCID: PMC3174680.
  65. Bateup HS, Takasaki KT, Saulnier JL, Denefrio CL, Sabatini BL. Loss of Tsc1 in vivo impairs hippocampal mGluR-LTD and increases excitatory synaptic function. J Neurosci. 2011 Jun 15; 31(24):8862-9. PMID: 21677170; PMCID: PMC3133739.
  66. Giessel AJ, Sabatini BL. Boosting of synaptic potentials and spine Ca transients by the peptide toxin SNX-482 requires alpha-1E-encoded voltage-gated Ca channels. PLoS One. 2011; 6(6):e20939. PMID: 21695265.
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  67. Kwon HB, Sabatini BL. Glutamate induces de novo growth of functional spines in developing cortex. Nature. 2011 Jun 02; 474(7349):100-4. PMID: 21552280; PMCID: PMC3107907.
  68. Higley MJ, Gittis AH, Oldenburg IA, Balthasar N, Seal RP, Edwards RH, Lowell BB, Kreitzer AC, Sabatini BL. Cholinergic interneurons mediate fast VGluT3-dependent glutamatergic transmission in the striatum. PLoS One. 2011 Apr 22; 6(4):e19155. PMID: 21544206.
    View in: PubMed
  69. Goda Y, Sabatini BL. Synaptic function and regulation. Curr Opin Neurobiol. 2011 Apr; 21(2):205-7. PMID: 21498068.
    View in: PubMed
  70. Giessel AJ, Sabatini BL. M1 muscarinic receptors boost synaptic potentials and calcium influx in dendritic spines by inhibiting postsynaptic SK channels. Neuron. 2010 Dec 09; 68(5):936-47. PMID: 21145006; PMCID: PMC3052967.
  71. Cheng J, Zhou X, Miller EL, Alvarez VA, Sabatini BL, Wong ST. Oriented Markov random field based dendritic spine segmentation for fluorescence microscopy images. Neuroinformatics. 2010 Oct; 8(3):157-70. PMID: 20585900.
    View in: PubMed
  72. Higley MJ, Sabatini BL. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci. 2010 Aug; 13(8):958-66. PMID: 20601948; PMCID: PMC2910780.
  73. Bateup HS, Sabatini BL. For synapses, it's depression not death. Cell. 2010 May 28; 141(5):750-2. PMID: 20510921.
    View in: PubMed
  74. Sturgill JF, Steiner P, Czervionke BL, Sabatini BL. Distinct domains within PSD-95 mediate synaptic incorporation, stabilization, and activity-dependent trafficking. J Neurosci. 2009 Oct 14; 29(41):12845-54. PMID: 19828799; PMCID: PMC2787089.
  75. Bloodgood BL, Giessel AJ, Sabatini BL. Biphasic synaptic Ca influx arising from compartmentalized electrical signals in dendritic spines. PLoS Biol. 2009 Sep; 7(9):e1000190. PMID: 19753104; PMCID: PMC2734993.
  76. Ding JB, Takasaki KT, Sabatini BL. Supraresolution imaging in brain slices using stimulated-emission depletion two-photon laser scanning microscopy. Neuron. 2009 Aug 27; 63(4):429-37. PMID: 19709626; PMCID: PMC2756148.
  77. Higley MJ, Soler-Llavina GJ, Sabatini BL. Cholinergic modulation of multivesicular release regulates striatal synaptic potency and integration. Nat Neurosci. 2009 Sep; 12(9):1121-8. PMID: 19668198; PMCID: PMC2733934.
  78. Beck D, Zhou X, Pham T, Sabatini B, Wong ST. An Image Driven Systems Biology Approach for Neurodegenerative Disease Studies in the TSC-mTOR Pathway. IEEE NIH Life Sci Syst Appl Workshop. 2009 May 02; 36-39. PMID: 21922078.
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  79. Steiner P, Higley MJ, Xu W, Czervionke BL, Malenka RC, Sabatini BL. Destabilization of the postsynaptic density by PSD-95 serine 73 phosphorylation inhibits spine growth and synaptic plasticity. Neuron. 2008 Dec 10; 60(5):788-802. PMID: 19081375; PMCID: PMC2671083.
  80. Higley MJ, Sabatini BL. Calcium signaling in dendrites and spines: practical and functional considerations. Neuron. 2008 Sep 25; 59(6):902-13. PMID: 18817730.
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  81. Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat Med. 2008 Aug; 14(8):837-42. PMID: 18568035; PMCID: PMC2772133.
  82. Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V. Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling. Cell Signal. 2008 Jun; 20(6):1084-91. PMID: 18308511; PMCID: PMC2435383.
  83. Xu W, Schlüter OM, Steiner P, Czervionke BL, Sabatini B, Malenka RC. Molecular dissociation of the role of PSD-95 in regulating synaptic strength and LTD. Neuron. 2008 Jan 24; 57(2):248-62. PMID: 18215622; PMCID: PMC3147180.
  84. Busetto G, Higley MJ, Sabatini BL. Developmental presence and disappearance of postsynaptically silent synapses on dendritic spines of rat layer 2/3 pyramidal neurons. J Physiol. 2008 Mar 15; 586(6):1519-27. PMID: 18202095; PMCID: PMC2375692.
  85. Bloodgood BL, Sabatini BL. Regulation of synaptic signalling by postsynaptic, non-glutamate receptor ion channels. J Physiol. 2008 Mar 15; 586(6):1475-80. PMID: 18096597; PMCID: PMC2375695.
  86. Sabatini BL. Neuroscience: neighbourly synapses. Nature. 2007 Dec 20; 450(7173):1173-5. PMID: 18097394.
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  87. Carter AG, Soler-Llavina GJ, Sabatini BL. Timing and location of synaptic inputs determine modes of subthreshold integration in striatal medium spiny neurons. J Neurosci. 2007 Aug 15; 27(33):8967-77. PMID: 17699678.
    View in: PubMed
  88. Alvarez VA, Ridenour DA, Sabatini BL. Distinct structural and ionotropic roles of NMDA receptors in controlling spine and synapse stability. J Neurosci. 2007 Jul 11; 27(28):7365-76. PMID: 17626197.
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  89. Cheng J, Zhou X, Miller E, Witt RM, Zhu J, Sabatini BL, Wong ST. A novel computational approach for automatic dendrite spines detection in two-photon laser scan microscopy. J Neurosci Methods. 2007 Sep 15; 165(1):122-34. PMID: 17629570; PMCID: PMC1989684.
  90. Bloodgood BL, Sabatini BL. Ca(2+) signaling in dendritic spines. Curr Opin Neurobiol. 2007 Jun; 17(3):345-51. PMID: 17451936.
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  91. Shankar GM, Bloodgood BL, Townsend M, Walsh DM, Selkoe DJ, Sabatini BL. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci. 2007 Mar 14; 27(11):2866-75. PMID: 17360908.
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  92. Zhang Y, Zhou X, Witt RM, Sabatini BL, Adjeroh D, Wong ST. Dendritic spine detection using curvilinear structure detector and LDA classifier. Neuroimage. 2007 Jun; 36(2):346-60. PMID: 17448688.
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  93. Bloodgood BL, Sabatini BL. Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines. Neuron. 2007 Jan 18; 53(2):249-60. PMID: 17224406.
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  94. Alvarez VA, Sabatini BL. Anatomical and physiological plasticity of dendritic spines. Annu Rev Neurosci. 2007; 30:79-97. PMID: 17280523.
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  95. Alvarez VA, Ridenour DA, Sabatini BL. Retraction of synapses and dendritic spines induced by off-target effects of RNA interference. J Neurosci. 2006 Jul 26; 26(30):7820-5. PMID: 16870727.
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  96. Soler-Llavina GJ, Sabatini BL. Synapse-specific plasticity and compartmentalized signaling in cerebellar stellate cells. Nat Neurosci. 2006 Jun; 9(6):798-806. PMID: 16680164.
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  97. Zhou X, Zhu J, Liu KY, Sabatini BL, Wong ST. Mutual information-based feature selection in studying perturbation of dendritic structure caused by TSC2 inactivation. Neuroinformatics. 2006; 4(1):81-94. PMID: 16595860.
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  98. Tavazoie SF, Alvarez VA, Ridenour DA, Kwiatkowski DJ, Sabatini BL. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci. 2005 Dec; 8(12):1727-34. PMID: 16286931.
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  99. Bloodgood BL, Sabatini BL. Neuronal activity regulates diffusion across the neck of dendritic spines. Science. 2005 Nov 04; 310(5749):866-9. PMID: 16272125.
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  100. Ngo-Anh TJ, Bloodgood BL, Lin M, Sabatini BL, Maylie J, Adelman JP. SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines. Nat Neurosci. 2005 May; 8(5):642-9. PMID: 15852011.
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  101. Carter AG, Sabatini BL. State-dependent calcium signaling in dendritic spines of striatal medium spiny neurons. Neuron. 2004 Oct 28; 44(3):483-93. PMID: 15504328.
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  102. Yasuda R, Nimchinsky EA, Scheuss V, Pologruto TA, Oertner TG, Sabatini BL, Svoboda K. Imaging calcium concentration dynamics in small neuronal compartments. Sci STKE. 2004 Feb 03; 2004(219):pl5. PMID: 14872098.
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  103. Yasuda R, Sabatini BL, Svoboda K. Plasticity of calcium channels in dendritic spines. Nat Neurosci. 2003 Sep; 6(9):948-55. PMID: 12937422.
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  104. Pologruto TA, Sabatini BL, Svoboda K. ScanImage: flexible software for operating laser scanning microscopes. Biomed Eng Online. 2003 May 17; 2:13. PMID: 12801419; PMCID: PMC161784.
  105. Oertner TG, Sabatini BL, Nimchinsky EA, Svoboda K. Facilitation at single synapses probed with optical quantal analysis. Nat Neurosci. 2002 Jul; 5(7):657-64. PMID: 12055631.
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  106. Sabatini BL, Oertner TG, Svoboda K. The life cycle of Ca(2+) ions in dendritic spines. Neuron. 2002 Jan 31; 33(3):439-52. PMID: 11832230.
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  107. Nimchinsky EA, Sabatini BL, Svoboda K. Structure and function of dendritic spines. Annu Rev Physiol. 2002; 64:313-53. PMID: 11826272.
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  108. Sabatini BL, Maravall M, Svoboda K. Ca(2+) signaling in dendritic spines. Curr Opin Neurobiol. 2001 Jun; 11(3):349-56. PMID: 11399434.
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  109. Sabatini BL, Svoboda K. Analysis of calcium channels in single spines using optical fluctuation analysis. Nature. 2000 Nov 30; 408(6812):589-93. PMID: 11117746.
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  110. Maravall M, Mainen ZF, Sabatini BL, Svoboda K. Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophys J. 2000 May; 78(5):2655-67. PMID: 10777761; PMCID: PMC1300854.
  111. Sabatini BL, Regehr WG. Timing of synaptic transmission. Annu Rev Physiol. 1999; 61:521-42. PMID: 10099700.
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  112. Sabatini BL, Regehr WG. Optical measurement of presynaptic calcium currents. Biophys J. 1998 Mar; 74(3):1549-63. PMID: 9512051; PMCID: PMC1299501.
  113. Sabatini BL, Regehr WG. Control of neurotransmitter release by presynaptic waveform at the granule cell to Purkinje cell synapse. J Neurosci. 1997 May 15; 17(10):3425-35. PMID: 9133368.
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  114. Sabatini BL, Regehr WG. Timing of neurotransmission at fast synapses in the mammalian brain. Nature. 1996 Nov 14; 384(6605):170-2. PMID: 8906792.
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  115. Sabatini BL, Regehr WG. Detecting changes in calcium influx which contribute to synaptic modulation in mammalian brain slice. Neuropharmacology. 1995 Nov; 34(11):1453-67. PMID: 8606793.
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  116. Mintz IM, Sabatini BL, Regehr WG. Calcium control of transmitter release at a cerebellar synapse. Neuron. 1995 Sep; 15(3):675-88. PMID: 7546746.
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  117. Blumenfeld H, Zablow L, Sabatini B. Evaluation of cellular mechanisms for modulation of calcium transients using a mathematical model of fura-2 Ca2+ imaging in Aplysia sensory neurons. Biophys J. 1992 Oct; 63(4):1146-64. PMID: 1420931; PMCID: PMC1262252.
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