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John A. Alberta Jr., Ph.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Reitman ZJ, Paolella BR, Bergthold G, Pelton K, Becker S, Jones R, Sinai CE, Malkin H, Huang Y, Grimmet L, Herbert ZT, Sun Y, Weatherbee JL, Alberta JA, Daley JF, Rozenblatt-Rosen O, Condurat AL, Qian K, Khadka P, Segal RA, Haas-Kogan D, Filbin MG, Suva ML, Regev A, Stiles CD, Kieran MW, Goumnerova L, Ligon KL, Shalek AK, Bandopadhayay P, Beroukhim R. Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells. Nat Commun. 2019 08 19; 10(1):3731. PMID: 31427603.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  2. Pal S, Kozono D, Yang X, Fendler W, Fitts W, Ni J, Alberta JA, Zhao J, Liu KX, Bian J, Truffaux N, Weiss WA, Resnick AC, Bandopadhayay P, Ligon KL, DuBois SG, Mueller S, Chowdhury D, Haas-Kogan DA. Dual HDAC and PI3K Inhibition Abrogates NF?B- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas. Cancer Res. 2018 07 15; 78(14):4007-4021. PMID: 29760046.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  3. Singh SK, Fiorelli R, Kupp R, Rajan S, Szeto E, Lo Cascio C, Maire CL, Sun Y, Alberta JA, Eschbacher JM, Ligon KL, Berens ME, Sanai N, Mehta S. Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-ß Pathway. Cell Rep. 2017 06 13; 19(11):2410-2412. PMID: 28614724.
    Citations: 1     Fields:    
  4. Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, Garraway LA, Rosen N, Gray NS, Agar NY, Buhrlage SJ, Segal RA, Stiles CD. A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas. Neuro Oncol. 2017 06 01; 19(6):774-785. PMID: 28082416.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  5. Zhou J, Tien AC, Alberta JA, Ficarro SB, Griveau A, Sun Y, Deshpande JS, Card JD, Morgan-Smith M, Michowski W, Hashizume R, James CD, Ligon KL, Snider WD, Sicinski P, Marto JA, Rowitch DH, Stiles CD. A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2. Cell Rep. 2017 03 28; 18(13):3167-3177. PMID: 28355568.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  6. Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D, Wei G, Wang B, Tsherniak A, Vazquez F, Weir BA, Root DE, Cowley GS, Buhrlage SJ, Stiles CD, Ebert BL, Hahn WC, Reed R, Beroukhim R. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 2017 02 08; 6. PMID: 28177281.
    Citations: 26     Fields:    Translation:HumansCells
  7. Edwards AL, Meijer DH, Guerra RM, Molenaar RJ, Alberta JA, Bernal F, Bird GH, Stiles CD, Walensky LD. Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. ACS Chem Biol. 2016 11 18; 11(11):3146-3153. PMID: 27643505.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Singh SK, Fiorelli R, Kupp R, Rajan S, Szeto E, Lo Cascio C, Maire CL, Sun Y, Alberta JA, Eschbacher JM, Ligon KL, Berens ME, Sanai N, Mehta S. Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-ß Pathway. Cell Rep. 2016 07 26; 16(4):950-966. PMID: 27396340.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  9. Meijer DH, Sun Y, Liu T, Kane MF, Alberta JA, Adelmant G, Kupp R, Marto JA, Rowitch DH, Nakatani Y, Stiles CD, Mehta S. An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells. J Neurosci. 2014 Jun 18; 34(25):8507-18. PMID: 24948806.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH. Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 05; 81(3):574-87. PMID: 24507192.
    Citations: 30     Fields:    Translation:AnimalsCells
  11. Liu X, Ide JL, Norton I, Marchionni MA, Ebling MC, Wang LY, Davis E, Sauvageot CM, Kesari S, Kellersberger KA, Easterling ML, Santagata S, Stuart DD, Alberta J, Agar JN, Stiles CD, Agar NY. Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging. Sci Rep. 2013 Oct 04; 3:2859. PMID: 24091529.
    Citations: 45     Fields:    Translation:HumansAnimals
  12. Koleva RI, Ficarro SB, Radomska HS, Carrasco-Alfonso MJ, Alberta JA, Webber JT, Luckey CJ, Marcucci G, Tenen DG, Marto JA. C/EBPa and DEK coordinately regulate myeloid differentiation. Blood. 2012 May 24; 119(21):4878-88. PMID: 22474248.
    Citations: 26     Fields:    Translation:HumansCells
  13. Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC, Fu H, Petryniak MA, Potter GB, Liu Z, Powers JF, Runquist IS, Rowitch DH, Stiles CD. Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron. 2011 Mar 10; 69(5):906-17. PMID: 21382551.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  14. Mehta S, Huillard E, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA, Kane MF, Theisen M, Ligon KL, Rowitch DH, Stiles CD. The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell. 2011 Mar 08; 19(3):359-71. PMID: 21397859.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  15. Girnun GD, Naseri E, Vafai SB, Qu L, Szwaya JD, Bronson R, Alberta JA, Spiegelman BM. Synergy between PPARgamma ligands and platinum-based drugs in cancer. Cancer Cell. 2007 May; 11(5):395-406. PMID: 17482130.
    Citations: 65     Fields:    
  16. Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007 Feb 15; 53(4):503-17. PMID: 17296553.
    Citations: 232     Fields:    Translation:AnimalsCells
  17. Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD, Rowitch DH. Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7853-8. PMID: 16682644.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  18. Guertin AD, Zhang DP, Mak KS, Alberta JA, Kim HA. Microanatomy of axon/glial signaling during Wallerian degeneration. J Neurosci. 2005 Mar 30; 25(13):3478-87. PMID: 15800203.
    Citations: 70     Fields:    Translation:AnimalsCells
  19. Sauvageot C, Dahia PL, Lipan O, Park JK, Chang MS, Alberta JA, Stiles CD. Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures. J Neurobiol. 2005 Jan; 62(1):121-33. PMID: 15389679.
    Citations: 1     Fields:    Translation:AnimalsCells
  20. Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004 Dec 24; 306(5705):2255-7. PMID: 15618518.
    Citations: 201     Fields:    Translation:Animals
  21. Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science. 2004 Dec 17; 306(5704):2111-5. PMID: 15604411.
    Citations: 171     Fields:    Translation:HumansAnimalsCells
  22. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol. 2004 May; 63(5):499-509. PMID: 15198128.
    Citations: 150     Fields:    Translation:HumansAnimalsCells
  23. Bithell A, Alberta J, Hornby F, Stiles CD, Williams BP. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Brain Res Dev Brain Res. 2003 Dec 19; 146(1-2):107-18. PMID: 14643017.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  24. Alberta JA, Park SK, Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD, Rowitch DH. Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain. Mol Cell Neurosci. 2001 Oct; 18(4):434-41. PMID: 11640898.
    Citations: 23     Fields:    Translation:AnimalsCells
  25. Alberta JA, Segal RA. Generation and utilization of phosphorylation state-specific antibodies to investigate signaling pathways. Curr Protoc Neurosci. 2001 May; Chapter 3:Unit 3.14. PMID: 18428463.
    Citations: 2     Fields:    Translation:AnimalsCells
  26. Kilic T, Alberta JA, Zdunek PR, Acar M, Iannarelli P, O'Reilly T, Buchdunger E, Black PM, Stiles CD. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res. 2000 Sep 15; 60(18):5143-50. PMID: 11016641.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  27. Lu QR, Yuk D, Alberta JA, Zhu Z, Pawlitzky I, Chan J, McMahon AP, Stiles CD, Rowitch DH. Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. 2000 Feb; 25(2):317-29. PMID: 10719888.
    Citations: 244     Fields:    Translation:AnimalsCells
  28. Park JK, Williams BP, Alberta JA, Stiles CD. Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner. J Neurosci. 1999 Dec 01; 19(23):10383-9. PMID: 10575035.
    Citations: 7     Fields:    Translation:AnimalsCells
  29. Alberta JA, Auger KR, Batt D, Iannarelli P, Hwang G, Elliott HL, Duke R, Roberts TM, Stiles CD. Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway. J Biol Chem. 1999 Oct 22; 274(43):31062-7. PMID: 10521506.
    Citations: 5     Fields:    Translation:AnimalsCells
  30. Kwon YK, Bhattacharyya A, Alberta JA, Giannobile WV, Cheon K, Stiles CD, Pomeroy SL. Activation of ErbB2 during wallerian degeneration of sciatic nerve. J Neurosci. 1997 Nov 01; 17(21):8293-9. PMID: 9334404.
    Citations: 25     Fields:    Translation:AnimalsCells
  31. Shamah SM, Alberta JA, Giannobile WV, Guha A, Kwon YK, Carroll RS, Black PM, Stiles CD. Detection of activated platelet-derived growth factor receptors in human meningioma. Cancer Res. 1997 Sep 15; 57(18):4141-7. PMID: 9307305.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  32. Alberta JA, Stiles CD. Phosphorylation-directed antibodies in high-flux screens for compounds that modulate signal transduction. Biotechniques. 1997 Sep; 23(3):490-3. PMID: 9298221.
    Citations:    Fields:    Translation:HumansCells
  33. Williams BP, Park JK, Alberta JA, Muhlebach SG, Hwang GY, Roberts TM, Stiles CD. A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron. 1997 Apr; 18(4):553-62. PMID: 9136765.
    Citations: 26     Fields:    Translation:AnimalsCells
  34. Segal RA, Bhattacharyya A, Rua LA, Alberta JA, Stephens RM, Kaplan DR, Stiles CD. Differential utilization of Trk autophosphorylation sites. J Biol Chem. 1996 Aug 16; 271(33):20175-81. PMID: 8702742.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.