Harvard Catalyst Profiles

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David L. Van Vactor Jr., Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS123207 (VAN VACTOR, DAVID L.) Jul 1, 2021 - Dec 31, 2022
    Novel Targets that Modulate Multiple Adult Models of ALS in Drosophila
    Role: Principal Investigator
  2. R21NS119932 (VAN VACTOR, DAVID L.) Sep 30, 2020 - May 31, 2022
    Novel Regulation of Postsynaptic Assembly in Drosophila
    Role: Principal Investigator
  3. P01NS090994 (VAN VACTOR, DAVID L.) May 1, 2016 - Mar 31, 2021
    MicroRNA-Dependent Regulation of Synaptic and Behavioral Plasticity in Drosophila
    Role: Co-Principal Investigator
  4. P01NS066888 (VAN VACTOR, DAVID L.) Aug 1, 2010 - Jul 31, 2016
    Genetic Modeling for SMA Therapeutic Pathways
    Role: Principal Investigator
  5. R01NS069695 (VAN VACTOR, DAVID L.) Apr 1, 2010 - Mar 31, 2020
    Regulation of Synapse Morphogenesis in Drosophila
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Min S, Oh Y, Verma P, Whitehead SC, Yapici N, Van Vactor D, Suh GS, Liberles S. Control of feeding by Piezo-mediated gut mechanosensation in Drosophila. Elife. 2021 02 18; 10. PMID: 33599608; PMCID: PMC7920550.
    Citations: 13     Fields:    Translation:AnimalsCells
  2. Woods BJ, Van Vactor D. miRNA: local guardians of presynaptic function in plasticity and disease. RNA Biol. 2021 07; 18(7):1014-1024. PMID: 33586621.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  3. Chou VT, Johnson SA, Van Vactor D. Synapse development and maturation at the drosophila neuromuscular junction. Neural Dev. 2020 08 02; 15(1):11. PMID: 32741370.
    Citations: 8     Fields:    Translation:AnimalsCells
  4. Chou VT, Yesilyurt HG, Lai H, Long JB, Arnes M, Obbad K, Jones M, Sasaki H, Lucas LAG, Alworth S, Lee JS, Van Vactor D. 3D Particle Tracking for Noninvasive In Vivo Analysis of Synaptic Microtubule Dynamics in Dendrites and Neuromuscular Junctions of Drosophila. J Vis Exp. 2020 05 12; (159). PMID: 32478717.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. McNeill EM, Thompson C, Berke B, Chou VT, Rusch J, Duckworth A, DeProto J, Taylor A, Gates J, Gertler F, Keshishian H, Van Vactor D. Drosophila enabled promotes synapse morphogenesis and regulates active zone form and function. Neural Dev. 2020 03 17; 15(1):4. PMID: 32183907.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. McNeill EM, Warinner C, Alkins S, Taylor A, Heggeness H, DeLuca TF, Fulga TA, Wall DP, Griffith LC, Van Vactor D. The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells. Nat Commun. 2020 02 27; 11(1):1092. PMID: 32107390; PMCID: PMC7046720.
    Citations: 12     Fields:    Translation:AnimalsCells
  7. Donelson NC, Dixit R, Pichardo-Casas I, Chiu EY, Ohman RT, Slawson JB, Klein M, Fulga TA, Van Vactor D, Griffith LC. MicroRNAs Regulate Multiple Aspects of Locomotor Behavior in Drosophila. G3 (Bethesda). 2020 01 07; 10(1):43-55. PMID: 31694853.
    Citations: 1     Fields:    Translation:Animals
  8. Chou VT, Johnson S, Long J, Vounatsos M, Van Vactor D. dTACC restricts bouton addition and regulates microtubule organization at the Drosophila neuromuscular junction. Cytoskeleton (Hoboken). 2020 01; 77(1-2):4-15. PMID: 31702858.
    Citations: 2     Fields:    Translation:AnimalsCells
  9. Goodwin PR, Meng A, Moore J, Hobin M, Fulga TA, Van Vactor D, Griffith LC. MicroRNAs Regulate Sleep and Sleep Homeostasis in Drosophila. Cell Rep. 2018 06 26; 23(13):3776-3786. PMID: 29949763; PMCID: PMC6091868.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. You S, Fulga TA, Van Vactor D, Jackson FR. Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila. Genetics. 2018 03; 208(3):1195-1207. PMID: 29487148; PMCID: PMC5844331.
    Citations: 16     Fields:    Translation:AnimalsCells
  11. Van Vactor D, Sigrist SJ. Presynaptic morphogenesis, active zone organization and structural plasticity in Drosophila. Curr Opin Neurobiol. 2017 04; 43:119-129. PMID: 28388491; PMCID: PMC5501089.
    Citations: 24     Fields:    Translation:AnimalsCells
  12. Sharifkhodaei Z, Padash-Barmchi M, Gilbert MM, Samarasekera G, Fulga TA, Van Vactor D, Auld VJ. The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184. J Cell Sci. 2016 Apr 01; 129(7):1477-89. PMID: 26906422; PMCID: PMC4852718.
    Citations: 2     Fields:    Translation:AnimalsCells
  13. Fulga TA, McNeill EM, Binari R, Yelick J, Blanche A, Booker M, Steinkraus BR, Schnall-Levin M, Zhao Y, DeLuca T, Bejarano F, Han Z, Lai EC, Wall DP, Perrimon N, Van Vactor D. A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs. Nat Commun. 2015 Jun 17; 6:7279. PMID: 26081261.
    Citations: 32     Fields:    Translation:Animals
  14. Busto GU, Guven-Ozkan T, Fulga TA, Van Vactor D, Davis RL. microRNAs That Promote or Inhibit Memory Formation in Drosophila melanogaster. Genetics. 2015 Jun; 200(2):569-80. PMID: 26088433; PMCID: PMC4492380.
    Citations: 27     Fields:    Translation:AnimalsCells
  15. Guarani V, McNeill EM, Paulo JA, Huttlin EL, Fröhlich F, Gygi SP, Van Vactor D, Harper JW. QIL1 is a novel mitochondrial protein required for MICOS complex stability and cristae morphology. Elife. 2015 May 21; 4. PMID: 25997101.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  16. Mugat B, Akkouche A, Serrano V, Armenise C, Li B, Brun C, Fulga TA, Van Vactor D, Pélisson A, Chambeyron S. MicroRNA-Dependent Transcriptional Silencing of Transposable Elements in Drosophila Follicle Cells. PLoS Genet. 2015 May; 11(5):e1005194. PMID: 25993106; PMCID: PMC4451950.
    Citations: 10     Fields:    Translation:AnimalsCells
  17. Santa-Maria I, Alaniz ME, Renwick N, Cela C, Fulga TA, Van Vactor D, Tuschl T, Clark LN, Shelanski ML, McCabe BD, Crary JF. Dysregulation of microRNA-219 promotes neurodegeneration through post-transcriptional regulation of tau. J Clin Invest. 2015 Feb; 125(2):681-6. PMID: 25574843; PMCID: PMC4319412.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  18. Lu CS, Zhai B, Mauss A, Landgraf M, Gygi S, Van Vactor D. MicroRNA-8 promotes robust motor axon targeting by coordinate regulation of cell adhesion molecules during synapse development. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 26; 369(1652). PMID: 25135978.
    Citations: 18     Fields:    Translation:AnimalsCells
  19. Loya CM, McNeill EM, Bao H, Zhang B, Van Vactor D. miR-8 controls synapse structure by repression of the actin regulator enabled. Development. 2014 May; 141(9):1864-74. PMID: 24718988.
    Citations: 24     Fields:    Translation:AnimalsCells
  20. Marler KJ, Suetterlin P, Dopplapudi A, Rubikaite A, Adnan J, Maiorano NA, Lowe AS, Thompson ID, Pathania M, Bordey A, Fulga T, Van Vactor DL, Hindges R, Drescher U. BDNF promotes axon branching of retinal ganglion cells via miRNA-132 and p250GAP. J Neurosci. 2014 Jan 15; 34(3):969-79. PMID: 24431455; PMCID: PMC3891972.
    Citations: 42     Fields:    Translation:AnimalsCells
  21. Lowery LA, Stout A, Faris AE, Ding L, Baird MA, Davidson MW, Danuser G, Van Vactor D. Growth cone-specific functions of XMAP215 in restricting microtubule dynamics and promoting axonal outgrowth. Neural Dev. 2013 Dec 01; 8:22. PMID: 24289819.
    Citations: 26     Fields:    Translation:AnimalsCells
  22. Walker JA, Gouzi JY, Long JB, Huang S, Maher RC, Xia H, Khalil K, Ray A, Van Vactor D, Bernards R, Bernards A. Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency. PLoS Genet. 2013 Nov; 9(11):e1003958. PMID: 24278035.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  23. Berke B, Wittnam J, McNeill E, Van Vactor DL, Keshishian H. Retrograde BMP signaling at the synapse: a permissive signal for synapse maturation and activity-dependent plasticity. J Neurosci. 2013 Nov 06; 33(45):17937-50. PMID: 24198381.
    Citations: 58     Fields:    Translation:AnimalsCells
  24. Sen A, Dimlich DN, Guruharsha KG, Kankel MW, Hori K, Yokokura T, Brachat S, Richardson D, Loureiro J, Sivasankaran R, Curtis D, Davidow LS, Rubin LL, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):E2371-80. PMID: 23757500.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  25. Emerson MM, Long JB, Van Vactor D. Drosophila semaphorin2b is required for the axon guidance of a subset of embryonic neurons. Dev Dyn. 2013 Jul; 242(7):861-73. PMID: 23606306.
    Citations: 3     Fields:    Translation:AnimalsCells
  26. Gutlerner JL, Van Vactor D. Catalyzing curriculum evolution in graduate science education. Cell. 2013 May 09; 153(4):731-6. PMID: 23663771.
    Citations: 4     Fields:    
  27. Li W, Cressy M, Qin H, Fulga T, Van Vactor D, Dubnau J. MicroRNA-276a functions in ellipsoid body and mushroom body neurons for naive and conditioned olfactory avoidance in Drosophila. J Neurosci. 2013 Mar 27; 33(13):5821-33. PMID: 23536094.
    Citations: 23     Fields:    Translation:AnimalsCells
  28. Long JB, Van Vactor D. Embryonic and larval neural connectivity: progressive changes in synapse form and function at the neuromuscular junction mediated by cytoskeletal regulation. Wiley Interdiscip Rev Dev Biol. 2013 Nov-Dec; 2(6):747-65. PMID: 24123935.
    Citations: 3     Fields:    Translation:AnimalsCells
  29. Long JB, Bagonis M, Lowery LA, Lee H, Danuser G, Van Vactor D. Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamics. Mol Cell Biol. 2013 Apr; 33(8):1528-45. PMID: 23382075.
    Citations: 18     Fields:    Translation:AnimalsCells
  30. Lowery LA, Faris AE, Stout A, Van Vactor D. Neural Explant Cultures from Xenopus laevis. J Vis Exp. 2012 Oct 15; (68):e4232. PMID: 23295240.
    Citations: 17     Fields:    Translation:AnimalsCells
  31. McNeill E, Van Vactor D. MicroRNAs shape the neuronal landscape. Neuron. 2012 Aug 09; 75(3):363-79. PMID: 22884321.
    Citations: 137     Fields:    Translation:HumansAnimalsCells
  32. Bejarano F, Bortolamiol-Becet D, Dai Q, Sun K, Saj A, Chou YT, Raleigh DR, Kim K, Ni JQ, Duan H, Yang JS, Fulga TA, Van Vactor D, Perrimon N, Lai EC. A genome-wide transgenic resource for conditional expression of Drosophila microRNAs. Development. 2012 Aug; 139(15):2821-31. PMID: 22745315.
    Citations: 55     Fields:    Translation:AnimalsCells
  33. Pathania M, Torres-Reveron J, Yan L, Kimura T, Lin TV, Gordon V, Teng ZQ, Zhao X, Fulga TA, Van Vactor D, Bordey A. miR-132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons. PLoS One. 2012; 7(5):e38174. PMID: 22693596; PMCID: PMC3364964.
    Citations: 67     Fields:    Translation:AnimalsCells
  34. Long JB, Van Vactor D. Maintaining muscle mitochondria via transsynaptic signaling. Dev Cell. 2012 Feb 14; 22(2):238-9. PMID: 22340490.
    Citations:    Fields:    
  35. Smart AD, Course MM, Rawson J, Selleck S, Van Vactor D, Johnson KG. Heparan sulfate proteoglycan specificity during axon pathway formation in the Drosophila embryo. Dev Neurobiol. 2011 Jul; 71(7):608-18. PMID: 21500363.
    Citations: 18     Fields:    Translation:AnimalsCells
  36. Loya CM, Van Vactor D, Fulga TA. Understanding neuronal connectivity through the post-transcriptional toolkit. Genes Dev. 2010 Apr 01; 24(7):625-35. PMID: 20360381.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  37. Loya CM, Lu CS, Van Vactor D, Fulga TA. Transgenic microRNA inhibition with spatiotemporal specificity in intact organisms. Nat Methods. 2009 Dec; 6(12):897-903. PMID: 19915559.
    Citations: 111     Fields:    Translation:Animals
  38. Prakash S, McLendon HM, Dubreuil CI, Ghose A, Hwa J, Dennehy KA, Tomalty KM, Clark KL, Van Vactor D, Clandinin TR. Complex interactions amongst N-cadherin, DLAR, and Liprin-alpha regulate Drosophila photoreceptor axon targeting. Dev Biol. 2009 Dec 01; 336(1):10-9. PMID: 19766621.
    Citations: 20     Fields:    Translation:AnimalsCells
  39. Lowery LA, Van Vactor D. The trip of the tip: understanding the growth cone machinery. Nat Rev Mol Cell Biol. 2009 May; 10(5):332-43. PMID: 19373241.
    Citations: 318     Fields:    Translation:HumansAnimalsCells
  40. Tsai PI, Kao HH, Grabbe C, Lee YT, Ghose A, Lai TT, Peng KP, Van Vactor D, Palmer RH, Chen RH, Yeh SR, Chien CT. Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural Dev. 2008 Oct 16; 3:26. PMID: 18925939.
    Citations: 21     Fields:    Translation:AnimalsCells
  41. Chang HC, Dimlich DN, Yokokura T, Mukherjee A, Kankel MW, Sen A, Sridhar V, Fulga TA, Hart AC, Van Vactor D, Artavanis-Tsakonas S. Modeling spinal muscular atrophy in Drosophila. PLoS One. 2008 Sep 15; 3(9):e3209. PMID: 18791638.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  42. Fulga TA, Van Vactor D. Synapses and growth cones on two sides of a highwire. Neuron. 2008 Feb 07; 57(3):339-44. PMID: 18255027.
    Citations: 16     Fields:    Translation:AnimalsCells
  43. Lu CS, Van Vactor D. Synapse specificity: Wnts keep motor axons on target. Curr Biol. 2007 Oct 23; 17(20):R895-8. PMID: 17956753.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Johnson KG, Tenney AP, Ghose A, Duckworth AM, Higashi ME, Parfitt K, Marcu O, Heslip TR, Marsh JL, Schwarz TL, Flanagan JG, Van Vactor D. The HSPGs Syndecan and Dallylike bind the receptor phosphatase LAR and exert distinct effects on synaptic development. Neuron. 2006 Feb 16; 49(4):517-31. PMID: 16476662.
    Citations: 128     Fields:    Translation:AnimalsCells
  45. Van Vactor D, Wall DP, Johnson KG. Heparan sulfate proteoglycans and the emergence of neuronal connectivity. Curr Opin Neurobiol. 2006 Feb; 16(1):40-51. PMID: 16417999.
    Citations: 58     Fields:    Translation:AnimalsCells
  46. Rawson JM, Dimitroff B, Johnson KG, Rawson JM, Ge X, Van Vactor D, Selleck SB. The heparan sulfate proteoglycans Dally-like and Syndecan have distinct functions in axon guidance and visual-system assembly in Drosophila. Curr Biol. 2005 May 10; 15(9):833-8. PMID: 15886101.
    Citations: 25     Fields:    Translation:AnimalsCells
  47. Miller KE, DeProto J, Kaufmann N, Patel BN, Duckworth A, Van Vactor D. Direct observation demonstrates that Liprin-alpha is required for trafficking of synaptic vesicles. Curr Biol. 2005 Apr 12; 15(7):684-9. PMID: 15823543.
    Citations: 75     Fields:    Translation:AnimalsCells
  48. Lee H, Engel U, Rusch J, Scherrer S, Sheard K, Van Vactor D. The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance. Neuron. 2004 Jun 24; 42(6):913-26. PMID: 15207236.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  49. Johnson KG, Ghose A, Epstein E, Lincecum J, O'Connor MB, Van Vactor D. Axonal heparan sulfate proteoglycans regulate the distribution and efficiency of the repellent slit during midline axon guidance. Curr Biol. 2004 Mar 23; 14(6):499-504. PMID: 15043815.
    Citations: 95     Fields:    Translation:AnimalsCells
  50. Krueger NX, Reddy RS, Johnson K, Bateman J, Kaufmann N, Scalice D, Van Vactor D, Saito H. Functions of the ectodomain and cytoplasmic tyrosine phosphatase domains of receptor protein tyrosine phosphatase Dlar in vivo. Mol Cell Biol. 2003 Oct; 23(19):6909-21. PMID: 12972609.
    Citations: 15     Fields:    Translation:AnimalsCells
  51. Lee H, Van Vactor D. Neurons take shape. Curr Biol. 2003 Feb 18; 13(4):R152-61. PMID: 12593820.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  52. Johnson KG, Van Vactor D. Receptor protein tyrosine phosphatases in nervous system development. Physiol Rev. 2003 Jan; 83(1):1-24. PMID: 12506125.
    Citations: 101     Fields:    Translation:AnimalsCells
  53. Wills Z, Emerson M, Rusch J, Bikoff J, Baum B, Perrimon N, Van Vactor D. A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding. Neuron. 2002 Nov 14; 36(4):611-22. PMID: 12441051.
    Citations: 34     Fields:    Translation:AnimalsCells
  54. Emerson MM, Van Vactor D. Robo is Abl to block N-Cadherin function. Nat Cell Biol. 2002 Oct; 4(10):E227-30. PMID: 12360300.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  55. Ghose A, Van Vactor D. GAPs in Slit-Robo signaling. Bioessays. 2002 May; 24(5):401-4. PMID: 12001262.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  56. Patel BN, Van Vactor DL. Axon guidance: the cytoplasmic tail. Curr Opin Cell Biol. 2002 Apr; 14(2):221-9. PMID: 11891122.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  57. Kaufmann N, DeProto J, Ranjan R, Wan H, Van Vactor D. Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. Neuron. 2002 Mar 28; 34(1):27-38. PMID: 11931739.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  58. Hart AC, Krämer H, Van Vactor DL, Paidhungat M, Zipursky SL. Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments. Genes Dev. 1990 Nov; 4(11):1835-47. PMID: 2276620.
    Citations: 31     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.