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Choukri Mekkaoui, Ph.D.

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Research
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  1. R01HL131635 (MEKKAOUI, CHOUKRI) Apr 1, 2016 - Mar 31, 2021
    NIH/NHLBI
    Free-Breathing Diffusion Tensor MRI in Patients Following Myocardial Infarction
    Role: Principal Investigator
  2. R56HL125590 (MEKKAOUI, CHOUKRI) Sep 4, 2015 - Aug 31, 2016
    NIH/NHLBI
    Tracking Cardiac Remodeling in Humans Using In Vivo Diffusion Tensor MRI
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kostis WJ, Sargsyan D, Mekkaoui C, Moreyra AE, Cabrera J, Cosgrove NM, Sedjro JE, Kostis JB, Cushman WC, Pantazopoulos JS, Pressel SL, Davis BR. Association of orthostatic hypertension with mortality in the Systolic Hypertension in the Elderly Program. J Hum Hypertens. 2019 Feb 25. PMID: 30804464.
    Citations:    
  2. Fan Q, Tian Q, Ohringer NA, Nummenmaa A, Witzel T, Tobyne SM, Klawiter EC, Mekkaoui C, Rosen BR, Wald LL, Salat DH, Huang SY. Age-related alterations in axonal microstructure in the corpus callosum measured by high-gradient diffusion MRI. Neuroimage. 2019 Feb 18; 191:325-336. PMID: 30790671.
    Citations:    
  3. Fan Q, Nummenmaa A, Wichtmann B, Witzel T, Mekkaoui C, Schneider W, Wald LL, Huang SY. A comprehensive diffusion MRI dataset acquired on the MGH Connectome scanner in a biomimetic brain phantom. Data Brief. 2018 Jun; 18:334-339. PMID: 29896520.
    Citations:    
  4. Mekkaoui C, Jackowski MP, Kostis WJ, Stoeck CT, Thiagalingam A, Reese TG, Reddy VY, Ruskin JN, Kozerke S, Sosnovik DE. Myocardial Scar Delineation Using Diffusion Tensor Magnetic Resonance Tractography. J Am Heart Assoc. 2018 Feb 02; 7(3). PMID: 29420216.
    Citations: 1     Fields:    
  5. Fan Q, Nummenmaa A, Wichtmann B, Witzel T, Mekkaoui C, Schneider W, Wald LL, Huang SY. Validation of diffusion MRI estimates of compartment size and volume fraction in a biomimetic brain phantom using a human MRI scanner with 300?mT/m maximum gradient strength. Neuroimage. 2018 11 15; 182:469-478. PMID: 29337276.
    Citations: 1     Fields:    
  6. Mekkaoui C, Reese TG, Jackowski MP, Cauley SF, Setsompop K, Bhat H, Sosnovik DE. Diffusion Tractography of the Entire Left Ventricle by Using Free-breathing Accelerated Simultaneous Multisection Imaging. Radiology. 2017 03; 282(3):850-856. PMID: 27681278.
    Citations: 5     Fields:    Translation:Humans
  7. Mekkaoui C, Metellus P, Kostis WJ, Martuzzi R, Pereira FR, Beregi JP, Reese TG, Constable TR, Jackowski MP. Diffusion Tensor Imaging in Patients with Glioblastoma Multiforme Using the Supertoroidal Model. PLoS One. 2016; 11(1):e0146693. PMID: 26761637; PMCID: PMC4711969.
    Citations: 1     Fields:    Translation:Humans
  8. Mekkaoui C, Reese TG, Jackowski MP, Bhat H, Sosnovik DE. Diffusion MRI in the heart. NMR Biomed. 2017 Mar; 30(3). PMID: 26484848.
    Citations: 9     Fields:    Translation:HumansAnimals
  9. Greffier J, Macri F, Larbi A, Fernandez A, Pereira F, Mekkaoui C, Beregi JP. Dose reduction with iterative reconstruction in multi-detector CT: What is the impact on deformation of circular structures in phantom study? Diagn Interv Imaging. 2016 Feb; 97(2):187-96. PMID: 26298669.
    Citations: 1     Fields:    
  10. Pereira FR, Macri F, Jackowski MP, Kostis WJ, Gris JC, Beregi JP, Mekkaoui C. Diffusion tensor imaging in patients with obstetric antiphospholipid syndrome without neuropsychiatric symptoms. Eur Radiol. 2016 Apr; 26(4):959-68. PMID: 26201292.
    Citations: 1     Fields:    Translation:Humans
  11. Greffier J, Macri F, Larbi A, Fernandez A, Khasanova E, Pereira F, Mekkaoui C, Beregi JP. Dose reduction with iterative reconstruction: Optimization of CT protocols in clinical practice. Diagn Interv Imaging. 2015 May; 96(5):477-86. PMID: 25797211.
    Citations: 5     Fields:    Translation:Humans
  12. Stoeck CT, Kalinowska A, von Deuster C, Harmer J, Chan RW, Niemann M, Manka R, Atkinson D, Sosnovik DE, Mekkaoui C, Kozerke S. Dual-phase cardiac diffusion tensor imaging with strain correction. PLoS One. 2014; 9(9):e107159. PMID: 25191900; PMCID: PMC4156436.
    Citations: 17     Fields:    Translation:Humans
  13. Sosnovik DE, Mekkaoui C, Huang S, Chen HH, Dai G, Stoeck CT, Ngoy S, Guan J, Wang R, Kostis WJ, Jackowski MP, Wedeen VJ, Kozerke S, Liao R. Microstructural impact of ischemia and bone marrow-derived cell therapy revealed with diffusion tensor magnetic resonance imaging tractography of the heart in vivo. Circulation. 2014 Apr 29; 129(17):1731-41. PMID: 24619466.
    Citations: 27     Fields:    Translation:HumansAnimalsCTClinical Trials
  14. Mekkaoui C, Porayette P, Jackowski MP, Kostis WJ, Dai G, Sanders S, Sosnovik DE. Diffusion MRI tractography of the developing human fetal heart. PLoS One. 2013; 8(8):e72795. PMID: 23991152; PMCID: PMC3753231.
    Citations: 10     Fields:    Translation:Humans
  15. Chen HH, Mekkaoui C, Cho H, Ngoy S, Marinelli B, Waterman P, Nahrendorf M, Liao R, Josephson L, Sosnovik DE. Fluorescence tomography of rapamycin-induced autophagy and cardioprotection in vivo. Circ Cardiovasc Imaging. 2013 May 01; 6(3):441-7. PMID: 23537953; PMCID: PMC3805276.
    Citations: 8     Fields:    Translation:AnimalsCells
  16. McGill LA, Ismail TF, Nielles-Vallespin S, Ferreira P, Scott AD, Roughton M, Kilner PJ, Ho SY, McCarthy KP, Gatehouse PD, de Silva R, Speier P, Feiweier T, Mekkaoui C, Sosnovik DE, Prasad SK, Firmin DN, Pennell DJ. Reproducibility of in-vivo diffusion tensor cardiovascular magnetic resonance in hypertrophic cardiomyopathy. J Cardiovasc Magn Reson. 2012 Dec 24; 14:86. PMID: 23259835; PMCID: PMC3551746.
    Citations: 28     Fields:    Translation:Humans
  17. Mekkaoui C, Huang S, Chen HH, Dai G, Reese TG, Kostis WJ, Thiagalingam A, Maurovich-Horvat P, Ruskin JN, Hoffmann U, Jackowski MP, Sosnovik DE. Fiber architecture in remodeled myocardium revealed with a quantitative diffusion CMR tractography framework and histological validation. J Cardiovasc Magn Reson. 2012 Oct 12; 14:70. PMID: 23061749; PMCID: PMC3506570.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  18. Nielles-Vallespin S, Mekkaoui C, Gatehouse P, Reese TG, Keegan J, Ferreira PF, Collins S, Speier P, Feiweier T, de Silva R, Jackowski MP, Pennell DJ, Sosnovik DE, Firmin D. In vivo diffusion tensor MRI of the human heart: reproducibility of breath-hold and navigator-based approaches. Magn Reson Med. 2013 Aug; 70(2):454-65. PMID: 23001828; PMCID: PMC3864770.
    Citations: 34     Fields:    Translation:Humans
  19. Huang S, Chen HH, Yuan H, Dai G, Schuhle DT, Mekkaoui C, Ngoy S, Liao R, Caravan P, Josephson L, Sosnovik DE. Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. Circ Cardiovasc Imaging. 2011 Nov; 4(6):729-37. PMID: 21836081; PMCID: PMC3370828.
    Citations: 17     Fields:    Translation:AnimalsCells
  20. Kerbaul F, By Y, Gariboldi V, Mekkaoui C, Fesler P, Collart F, Brimioulle S, Jammes Y, Ruf J, Guieu R. Acute pulmonary embolism decreases adenosine plasma levels in anesthetized pigs. ISRN Cardiol. 2011; 2011:750301. PMID: 22347654; PMCID: PMC3262497.
    Citations: 2     
  21. Liu YH, Sahul Z, Weyman CA, Dione DP, Dobrucki WL, Mekkaoui C, Brennan MP, Ryder WJ, Sinusas AJ. Accuracy and reproducibility of absolute quantification of myocardial focal tracer uptake from molecularly targeted SPECT/CT: a canine validation. J Nucl Med. 2011 Mar; 52(3):453-60. PMID: 21321271; PMCID: PMC3137905.
    Citations: 1     Fields:    Translation:Animals
  22. Mekkaoui C, Jadbabaie F, Dione DP, Meoli DF, Purushothaman K, Belardinelli L, Sinusas AJ. Effects of adenosine and a selective A2A adenosine receptor agonist on hemodynamic and thallium-201 and technetium-99m-sestaMIBI biodistribution and kinetics. JACC Cardiovasc Imaging. 2009 Oct; 2(10):1198-208. PMID: 19833310.
    Citations: 10     Fields:    Translation:Animals
  23. Metellus P, Dutertre G, Mekkaoui C, Nanni I, Fuentes S, Ait-Ameur A, Chinot O, Dufour H, Figarella-Branger D, Cordoliani YS, Grisoli F. [Value of relative cerebral blood volume measurement using perfusion MRI in glioma management]. Neurochirurgie. 2008 Aug; 54(4):503-11. PMID: 18573509.
    Citations:    Fields:    Translation:Humans
  24. Donnet A, Metellus P, Levrier O, Mekkaoui C, Fuentes S, Dufour H, Conrath J, Grisoli F. Endovascular treatment of idiopathic intracranial hypertension: clinical and radiologic outcome of 10 consecutive patients. Neurology. 2008 Feb 19; 70(8):641-7. PMID: 18285539.
    Citations: 31     Fields:    Translation:HumansCTClinical Trials
  25. Fuchs AT, Kuehnl A, Pelisek J, Rolland PH, Mekkaoui C, Netz H, Nikol S. Meta-analysis shows similar risk of thrombosis after drug-eluting stent, bare-metal stent, or angioplasty. Endothelium. 2008 Jan-Feb; 15(1):93-100. PMID: 18568949.
    Citations: 1     Fields:    Translation:Humans
  26. Fuchs AT, Kuehnl A, Pelisek J, Rolland PH, Mekkaoui C, Netz H, Nikol S. Inhibition of restenosis formation without compromising reendothelialization as a potential solution to thrombosis following angioplasty? Endothelium. 2008 Jan-Feb; 15(1):85-92. PMID: 18568948.
    Citations: 7     Fields:    Translation:AnimalsCells
  27. Kerbaul F, Gariboldi V, Giorgi R, Mekkaoui C, Guieu R, Fesler P, Gouin F, Brimioulle S, Collart F. Effects of levosimendan on acute pulmonary embolism-induced right ventricular failure. Crit Care Med. 2007 Aug; 35(8):1948-54. PMID: 17568324.
    Citations: 8     Fields:    Translation:Animals
  28. Golda A, Pelisek J, Klocke R, Engelmann MG, Rolland PH, Mekkaoui C, Nikol S. Small poly-L-lysines improve cationic lipid-mediated gene transfer in vascular cells in vitro and in vivo. J Vasc Res. 2007; 44(4):273-82. PMID: 17406119.
    Citations:    Fields:    Translation:AnimalsCells
  29. Pelisek J, Fuchs AT, Kuehnl A, Tian W, Kuhlmann MT, Rolland PH, Mekkaoui C, Gaedtke L, Nikol S. C-type natriuretic peptide for reduction of restenosis: gene transfer is superior over single peptide administration. J Gene Med. 2006 Jul; 8(7):835-44. PMID: 16602133.
    Citations: 5     Fields:    Translation:AnimalsCells
  30. Kerbaul F, Bellezza M, Mekkaoui C, Feier H, Guidon C, Gouvernet J, Rolland PH, Gouin F, Mesana T, Collart F. Sevoflurane alters right ventricular performance but not pulmonary vascular resistance in acutely instrumented anesthetized pigs. J Cardiothorac Vasc Anesth. 2006 Apr; 20(2):209-16. PMID: 16616661.
    Citations: 3     Fields:    Translation:Animals
  31. Rolland PH, Vidal V, Mekkaoui C, Bertrand MF, Levrier O, Bartoli JM. Embolization-driven occlusion of the abdominal aortic aneurysmal sac as the basis of prevention of endoleaks in a new swine model. Eur J Vasc Endovasc Surg. 2006 Jan; 31(1):28-35. PMID: 16202632.
    Citations: 1     Fields:    Translation:Animals
  32. Kühnl A, Pelisek J, Tian W, Kuhlmann M, Rolland PH, Mekkaoui C, Fuchs A, Nikol S. C-type natriuretic peptide inhibits constrictive remodeling without compromising re-endothelialization in balloon-dilated renal arteries. J Endovasc Ther. 2005 Apr; 12(2):171-82. PMID: 15823063.
    Citations: 6     Fields:    Translation:AnimalsPHPublic Health
  33. Rolland PH, Mekkaoui C, Vidal V, Berry JL, Moore JE, Moreno M, Amabile P, Bartoli JM. Compliance matching stent placement in the carotid artery of the swine promotes optimal blood flow and attenuates restenosis. Eur J Vasc Endovasc Surg. 2004 Oct; 28(4):431-8. PMID: 15350569.
    Citations: 5     Fields:    Translation:Animals
  34. Collart F, Kerbaul F, Mekkaoui C, Riberi A, Gariboldi V, Rolland PH, Métras D, Mesana TG. Balloon-pump-induced pulsatility improves coronary and carotid flows in an experimental model of BioMedicus left ventricular assistance. Artif Organs. 2004 Aug; 28(8):743-6. PMID: 15270957.
    Citations:    Fields:    Translation:Animals
  35. Pelisek J, Kuehnl A, Rolland PH, Mekkaoui C, Fuchs A, Walker GF, Ogris M, Wagner E, Nikol S. Functional analysis of genomic DNA, cDNA, and nucleotide sequence of the mature C-type natriuretic peptide gene in vascular cells. Arterioscler Thromb Vasc Biol. 2004 Sep; 24(9):1646-51. PMID: 15231517.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  36. Engelmann MG, Shimizu M, Pelisek J, Fuchs A, Golda A, Mekkaoui C, Fraunberger P, Rolland PH, Nikol S. Comparison of surgical versus endovascular occlusion models in pig femoral arteries. J Endovasc Ther. 2004 Feb; 11(1):71-9. PMID: 14748626.
    Citations:    Fields:    Translation:Animals
  37. Mekkaoui C, Rolland PH, Friggi A, Rasigni M, Mesana TG. Pressure-flow loops and instantaneous input impedance in the thoracic aorta: another way to assess the effect of aortic bypass graft implantation on myocardial, brain, and subdiaphragmatic perfusion. J Thorac Cardiovasc Surg. 2003 Mar; 125(3):699-710. PMID: 12658214.
    Citations: 1     Fields:    Translation:Animals
  38. Levrier O, Mekkaoui C, Rolland PH, Murphy K, Cabrol P, Moulin G, Bartoli JM, Raybaud C. Efficacy and low vascular toxicity of embolization with radical versus anionic polymerization of n-butyl-2-cyanoacrylate (NBCA). An experimental study in the swine. J Neuroradiol. 2003 Mar; 30(2):95-102. PMID: 12717295.
    Citations: 9     Fields:    Translation:Animals
  39. Pelisek J, Fuchs A, Engelmann MG, Shimizu M, Golda A, Mekkaoui C, Rolland PH, Nikol S. Vascular endothelial growth factor response in porcine coronary and peripheral arteries using nonsurgical occlusion model, local delivery, and liposome-mediated gene transfer. Endothelium. 2003; 10(4-5):247-55. PMID: 14660085.
    Citations: 1     Fields:    Translation:Animals
  40. Rolland PH, Mekkaoui C, Palassi M, Friggi A, Moulin G, Piquet P, Bartoli JM. Efficacy of local molsidomine delivery from a hydrogel-coated angioplasty balloon catheter in the atherosclerotic porcine model. Cardiovasc Intervent Radiol. 2003 Jan-Feb; 26(1):65-72. PMID: 12491015.
    Citations: 1     Fields:    Translation:Animals
  41. Nikol S, Pelisek J, Engelmann MG, Shimizu M, Fuchs A, Golda A, Armeanu S, Mekkaoui C, Rolland PH. Vascular endothelial growth factor (VEGF165) and its influence on angiogenesis versus arteriogenesis in different vascular beds. J Endovasc Ther. 2002 Dec; 9(6):842-54. PMID: 12546587.
    Citations: 1     Fields:    Translation:Animals
  42. Feier H, Mekkaoui C, Drevet JB, Sérée Y, Richomme C, Rolland PH, Mesana TG. A novel, valveless ventricular assist device: the FishTail pump. First experimental in vivo studies. Artif Organs. 2002 Dec; 26(12):1026-31. PMID: 12460380.
    Citations:    Fields:    Translation:Animals
  43. Pelisek J, Engelmann MG, Golda A, Fuchs A, Armeanu S, Shimizu M, Mekkaoui C, Rolland PH, Nikol S. Optimization of nonviral transfection: variables influencing liposome-mediated gene transfer in proliferating vs. quiescent cells in culture and in vivo using a porcine restenosis model. J Mol Med (Berl). 2002 Nov; 80(11):724-36. PMID: 12436349.
    Citations: 4     Fields:    Translation:AnimalsCells
  44. Nikol S, Engelmann MG, Pelisek J, Fuchs A, Golda A, Shimizu M, Mekkaoui C, Rolland PH. Local perivascular application of low amounts of a plasmid encoding for vascular endothelial growth factor (VEGF165) is efficient for therapeutic angiogenesis in pigs. Acta Physiol Scand. 2002 Oct; 176(2):151-9. PMID: 12354175.
    Citations: 6     Fields:    Translation:Animals
  45. Rolland PH, Bartoli JM, Piquet P, Mekkaoui C, Nott SH, Moulin G, Amabile P, Mesana T. Local delivery of NO-donor molsidomine post-PTA improves haemodynamics, wall mechanics and histomorphometry in atherosclerotic porcine SFA. Eur J Vasc Endovasc Surg. 2002 Mar; 23(3):226-33. PMID: 11914009.
    Citations:    Fields:    Translation:Animals
  46. Berry JL, Manoach E, Mekkaoui C, Rolland PH, Moore JE, Rachev A. Hemodynamics and wall mechanics of a compliance matching stent: in vitro and in vivo analysis. J Vasc Interv Radiol. 2002 Jan; 13(1):97-105. PMID: 11788701.
    Citations: 13     Fields:    Translation:Animals
  47. Mekkaoui C, Friggi A, Rolland PH, Bodard H, Piquet P, Bartoli JM, Mesana T. Simultaneous measurements of arterial diameter and blood pressure to determine the arterial compliance, wall mechanics and stresses in vivo. Eur J Vasc Endovasc Surg. 2001 Mar; 21(3):208-13. PMID: 11352678.
    Citations: 1     Fields:    Translation:Animals
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.