Harvard Catalyst Profiles

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Suzanne Elsasser, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D. Allosteric control of Ubp6 and the proteasome via a bidirectional switch. Nat Commun. 2022 02 11; 13(1):838. PMID: 35149681; PMCID: PMC8837689.
    Citations: 3     Fields:    Translation:AnimalsCells
  2. Martinez-Fonts K, Davis C, Tomita T, Elsasser S, Nager AR, Shi Y, Finley D, Matouschek A. The proteasome 19S cap and its ubiquitin receptors provide a versatile recognition platform for substrates. Nat Commun. 2020 01 24; 11(1):477. PMID: 31980598.
    Citations: 42     Fields:    Translation:Cells
  3. Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, Finley D. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. J Biol Chem. 2017 11 24; 292(47):19209-19225. PMID: 28972160; PMCID: PMC5702663.
    Citations: 58     Fields:    Translation:AnimalsCells
  4. Lee BH, Lu Y, Prado MA, Shi Y, Tian G, Sun S, Elsasser S, Gygi SP, King RW, Finley D. USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites. Nature. 2016 Apr 21; 532(7599):398-401. PMID: 27074503.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  5. Shi Y, Chen X, Elsasser S, Stocks BB, Tian G, Lee BH, Shi Y, Zhang N, de Poot SA, Tuebing F, Sun S, Vannoy J, Tarasov SG, Engen JR, Finley D, Walters KJ. Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome. Science. 2016 Feb 19; 351(6275). PMID: 26912900.
    Citations: 120     Fields:    Translation:AnimalsCells
  6. Isasa M, Rose CM, Elsasser S, Navarrete-Perea J, Paulo JA, Finley DJ, Gygi SP. Multiplexed, Proteome-Wide Protein Expression Profiling: Yeast Deubiquitylating Enzyme Knockout Strains. J Proteome Res. 2015 Dec 04; 14(12):5306-17. PMID: 26503604; PMCID: PMC4802358.
    Citations: 23     Fields:    Translation:AnimalsCells
  7. Aguileta MA, Korac J, Durcan TM, Trempe JF, Haber M, Gehring K, Elsasser S, Waidmann O, Fon EA, Husnjak K. The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13. J Biol Chem. 2015 Mar 20; 290(12):7492-505. PMID: 25666615.
    Citations: 23     Fields:    Translation:HumansCells
  8. Hanna J, Waterman D, Isasa M, Elsasser S, Shi Y, Gygi S, Finley D. Cuz1/Ynl155w, a zinc-dependent ubiquitin-binding protein, protects cells from metalloid-induced proteotoxicity. J Biol Chem. 2014 Jan 17; 289(3):1876-85. PMID: 24297164.
    Citations: 10     Fields:    Translation:AnimalsCells
  9. Elsasser S, Shi Y, Finley D. Binding of ubiquitin conjugates to proteasomes as visualized with native gels. Methods Mol Biol. 2012; 832:403-22. PMID: 22350901.
    Citations: 5     Fields:    Translation:AnimalsCells
  10. Fishbain S, Prakash S, Herrig A, Elsasser S, Matouschek A. Rad23 escapes degradation because it lacks a proteasome initiation region. Nat Commun. 2011 Feb 08; 2:192. PMID: 21304521.
    Citations: 53     Fields:    Translation:AnimalsCells
  11. Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 2010 Sep 09; 467(7312):179-84. PMID: 20829789.
    Citations: 469     Fields:    Translation:HumansAnimalsCells
  12. Husnjak K, Elsasser S, Zhang N, Chen X, Randles L, Shi Y, Hofmann K, Walters KJ, Finley D, Dikic I. Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature. 2008 May 22; 453(7194):481-8. PMID: 18497817.
    Citations: 323     Fields:    Translation:HumansAnimalsCells
  13. Schreiner P, Chen X, Husnjak K, Randles L, Zhang N, Elsasser S, Finley D, Dikic I, Walters KJ, Groll M. Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature. 2008 May 22; 453(7194):548-52. PMID: 18497827.
    Citations: 175     Fields:    Translation:HumansAnimalsCells
  14. Goh AM, Walters KJ, Elsasser S, Verma R, Deshaies RJ, Finley D, Howley PM. Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. BMC Biochem. 2008 Jan 30; 9:4. PMID: 18234089.
    Citations: 14     Fields:    Translation:HumansCells
  15. Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D. Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell. 2006 Oct 06; 127(1):99-111. PMID: 17018280.
    Citations: 193     Fields:    Translation:HumansAnimals
  16. Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat Cell Biol. 2006 Jul; 8(7):700-10. PMID: 16799550.
    Citations: 215     Fields:    Translation:AnimalsCells
  17. Elsasser S, Finley D. Delivery of ubiquitinated substrates to protein-unfolding machines. Nat Cell Biol. 2005 Aug; 7(8):742-9. PMID: 16056265.
    Citations: 170     Fields:    Translation:HumansAnimalsCells
  18. Schmidt M, Hanna J, Elsasser S, Finley D. Proteasome-associated proteins: regulation of a proteolytic machine. Biol Chem. 2005 Aug; 386(8):725-37. PMID: 16201867.
    Citations: 81     Fields:    Translation:Cells
  19. Elsasser S, Schmidt M, Finley D. Characterization of the proteasome using native gel electrophoresis. Methods Enzymol. 2005; 398:353-63. PMID: 16275342.
    Citations: 90     Fields:    Translation:Animals
  20. Elsasser S, Chandler-Militello D, Müller B, Hanna J, Finley D. Rad23 and Rpn10 serve as alternative ubiquitin receptors for the proteasome. J Biol Chem. 2004 Jun 25; 279(26):26817-22. PMID: 15117949.
    Citations: 150     Fields:    Translation:AnimalsCells
  21. Luo KQ, Elsasser S, Chang DC, Campbell JL. Regulation of the localization and stability of Cdc6 in living yeast cells. Biochem Biophys Res Commun. 2003 Jul 11; 306(4):851-9. PMID: 12821120.
    Citations: 8     Fields:    Translation:Cells
  22. Elsasser S, Gali RR, Schwickart M, Larsen CN, Leggett DS, Müller B, Feng MT, Tübing F, Dittmar GA, Finley D. Proteasome subunit Rpn1 binds ubiquitin-like protein domains. Nat Cell Biol. 2002 Sep; 4(9):725-30. PMID: 12198498.
    Citations: 186     Fields:    Translation:Cells
  23. Jang SW, Elsasser S, Campbell JL, Kim J. Identification of Cdc6 protein domains involved in interaction with Mcm2 protein and Cdc4 protein in budding yeast cells. Biochem J. 2001 Mar 15; 354(Pt 3):655-61. PMID: 11237870; PMCID: PMC1221697.
    Citations: 3     Fields:    Translation:AnimalsCells
  24. Elsasser S, Chi Y, Yang P, Campbell JL. Phosphorylation controls timing of Cdc6p destruction: A biochemical analysis. Mol Biol Cell. 1999 Oct; 10(10):3263-77. PMID: 10512865; PMCID: PMC25589.
    Citations: 74     Fields:    Translation:AnimalsCells
  25. Elsasser S, Lou F, Wang B, Campbell JL, Jong A. Interaction between yeast Cdc6 protein and B-type cyclin/Cdc28 kinases. Mol Biol Cell. 1996 Nov; 7(11):1723-35. PMID: 8930895; PMCID: PMC276021.
    Citations: 46     Fields:    Translation:Animals
  26. Rhode PR, Elsasser S, Campbell JL. Role of multifunctional autonomously replicating sequence binding factor 1 in the initiation of DNA replication and transcriptional control in Saccharomyces cerevisiae. Mol Cell Biol. 1992 Mar; 12(3):1064-77. PMID: 1545789.
    Citations: 43     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.