Harvard Catalyst Profiles

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Jacob Joseph, M.B.,B.S., M.D.

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Available: 09/04/18, Expires: 06/30/21

Use the Million Veteran Program cohort to analyze the impact of genetic variants in the risk and prognosis of heart failure Student can contribute to genetic analysis and presentation/publication Work will be performed at Veterans Affairs Boston Healthcare System

Available: 09/04/18, Expires: 06/30/21

Use the Million Veteran Program cohort to analyze the impact of genetic variants in the risk and prognosis of heart failure. Student can contribute to genetic analysis and presentation/publication. Work will be performed at Veterans Affairs Boston Healthcare System.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U19AG065188 (ALEXANDER, KAREN P) Sep 30, 2019 - Aug 31, 2026
    PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)
    Role Description: The goal of PREVENTABLE is to generate knowledge about the role of statins in older adults, a population in which risk/benefit for primary prevention has been under studied.
    Role: Co-PI of Clinical Sites Core and PI of VA Network
  2. I01CX001922 (JOSEPH, JACOB) Jul 1, 2019 - Jun 30, 2023
    Pragmatic Approaches to Capture and Ascertainment of Clinical Trial Endpoints
    Role Description: The aim of this project is to develop methods to capture clinical trial endpoints from electronic medical records( EMR) and compare EMR based capture to traditional methods of endpoint capture and ascertainment
    Role: Principal Investigator
  3. I01CX001737 (PHILLIPS, LAWRENCE S) Oct 1, 2018 - Sep 30, 2020
    Diabetic Complications and Genetic Variants in the Million Veterans Program
    Role Description: The project targets discovery of new genetic variants that should help to improve the healthcare of adults with diabetes. The effects of genetic variants on the risk of incident heart failure with preserved and reduced ejection fraction and on outcomes in heart failure will be examined in the context of diabetes as a risk factor.
    Role: Co-Investigator and lead of Heart Failure Genomics
  4. U01HL130163 (SOLOMON, SCOTT DAVID) Feb 15, 2016 - Jan 31, 2021
    INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated heart failure (INVESTED)
    Role Description: The goal of this study is to compare high dose influenza vaccine to standard dose vaccine in reducing the time to first composite of death or cardiopulmonary hospitalization. The aim of the national VA Consortium is to coordinate study participation of 34 VA sites. In this study, we will explore pragmatic approaches to clinical trial conduct such as enhancing site-based recruitment by providing lists of eligible subjects generated using the national VA database and centralized approaches to collection of clinical trial endpoints.
    Role: Co-PI of VA Network
  5. R21HL089734 (JOSEPH, JACOB) Apr 1, 2008 - Sep 30, 2011
    Selenium, Glutathione Peroxidase-1, and Homocysteine-induced Cardiac Remodeling
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Joseph J. Life's irreducible structure: Where are we, five decades later? Bioessays. 2020 Nov 09; e2000250. PMID: 33169412.
  2. Vaduganathan M, van Meijgaard J, Mehra MR, Joseph J, O'Donnell CJ, Warraich HJ. Prescription Fill Patterns for Commonly Used Drugs During the COVID-19 Pandemic in the United States. JAMA. 2020 06 23; 323(24):2524-2526. PMID: 32463459.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  3. Foster M, Albanese C, Chen Q, Sethares KA, Evans S, Lehmann LS, Spencer J, Joseph J. Heart Failure Dashboard Design and Validation to Improve Care of Veterans. Appl Clin Inform. 2020 01; 11(1):153-159. PMID: 32102107.
    Citations:    Fields:    
  4. Kurgansky KE, Schubert P, Parker R, Djousse L, Riebman JB, Gagnon DR, Joseph J. Association of pulse rate with outcomes in heart failure with reduced ejection fraction: a retrospective cohort study. BMC Cardiovasc Disord. 2020 02 26; 20(1):92. PMID: 32101141.
    Citations:    Fields:    Translation:Humans
  5. Banerjee A, Allan V, Denaxas S, Shah A, Kotecha D, Lambiase PD, Joseph J, Lund LH, Hemingway H. Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis. Europace. 2019 12 01; 21(12):1776-1784. PMID: 31408153.
    Citations: 1     Fields:    
  6. Djoussé L, Cook NR, Kim E, Bodar V, Walter J, Bubes V, Luttmann-Gibson H, Mora S, Joseph J, Lee IM, Albert CM, Buring JE, Gaziano JM, Manson JE. Supplementation With Vitamin D and Omega-3 Fatty Acids and Incidence of Heart Failure Hospitalization: VITAL-Heart Failure. Circulation. 2020 03 03; 141(9):784-786. PMID: 31709816.
    Citations: 1     Fields:    Translation:Humans
  7. Metra M, Teerlink JR, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Pang PS, Ponikowski P, Voors AA, Adams KF, Anker SD, Arias-Mendoza A, Avendaño P, Bacal F, Böhm M, Bortman G, Cleland JGF, Cohen-Solal A, Crespo-Leiro MG, Dorobantu M, Echeverría LE, Ferrari R, Goland S, Goncalvesová E, Goudev A, Køber L, Lema-Osores J, Levy PD, McDonald K, Manga P, Merkely B, Mueller C, Pieske B, Silva-Cardoso J, Špinar J, Squire I, Stepinska J, Van Mieghem W, von Lewinski D, Wikström G, Yilmaz MB, Hagner N, Holbro T, Hua TA, Sabarwal SV, Severin T, Szecsödy P, Gimpelewicz C. Effects of Serelaxin in Patients with Acute Heart Failure. N Engl J Med. 2019 08 22; 381(8):716-726. PMID: 31433919.
    Citations: 9     Fields:    Translation:Humans
  8. Tong S, Zhang L, Joseph J, Jiang X. A novel, potential therapeutic target in diabetic cardiomyocytes: ROCK2. Int J Cardiol. 2019 08 01; 288:121. PMID: 30948216.
    Citations: 1     Fields:    Translation:HumansCells
  9. Imran TF, Kurgansky KE, Patel YR, Orkaby AR, McLean RR, Ho YL, Cho K, Gaziano JM, Djousse L, Gagnon DR, Joseph J. Serial sodium values and adverse outcomes in heart failure with preserved ejection fraction. Int J Cardiol. 2019 09 01; 290:119-124. PMID: 30929975.
    Citations: 1     Fields:    Translation:Humans
  10. Joseph J. Orchestrating Metabolic Flexibility: PGC-1a and Clinical Heart Failure. Am J Med Sci. 2019 04; 357(4):273-274. PMID: 30711188.
    Citations: 1     Fields:    Translation:Humans
  11. Zhang L, Joseph L, Joseph J. In Vivo and In Vitro Effects of Vasopressin V2 Receptor Antagonism on Myocardial Fibrosis in Rats. Am J Med Sci. 2019 02; 357(2):151-159. PMID: 30665496.
    Citations:    Fields:    Translation:Animals
  12. Tong S, Zhang L, Joseph J. Letter by Tong et al Regarding Article, "Efficacy and Safety of the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation and Concomitant Aspirin Therapy: A Meta-Analysis of Randomized Trials". Circulation. 2018 09 18; 138(12):1277-1278. PMID: 30354435.
    Citations:    Fields:    Translation:Humans
  13. Tong S, Zhang L, Joseph J, Jiang X. A potential and novel therapeutic approach to ischemic heart failure: Algisyl-LVR. Int J Cardiol. 2018 11 15; 271:209. PMID: 30100223.
    Citations:    Fields:    Translation:Humans
  14. Patel YR, Robbins JM, Kurgansky KE, Imran T, Orkaby AR, McLean RR, Ho YL, Cho K, Michael Gaziano J, Djousse L, Gagnon DR, Joseph J. Development and validation of a heart failure with preserved ejection fraction cohort using electronic medical records. BMC Cardiovasc Disord. 2018 06 28; 18(1):128. PMID: 29954337.
    Citations: 2     Fields:    Translation:Humans
  15. Patel YR, Kurgansky KE, Imran TF, Orkaby AR, McLean RR, Ho YL, Cho K, Gaziano JM, Djousse L, Gagnon DR, Joseph J. Prognostic Significance of Baseline Serum Sodium in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2018 06 13; 7(12). PMID: 29899018.
    Citations: 1     Fields:    Translation:Humans
  16. Srivastava A, Do JM, Sales VL, Ly S, Joseph J. Impact of patient-centred home telehealth programme on outcomes in heart failure. J Telemed Telecare. 2019 Aug; 25(7):425-430. PMID: 29793388.
    Citations: 1     Fields:    Translation:Humans
  17. Vardeny O, Udell JA, Joseph J, Farkouh ME, Hernandez AF, McGeer AJ, Talbot HK, Bhatt DL, Cannon CP, Goodman SG, Anand I, DeMets DL, Temte J, Wittes J, Nichol K, Yancy CW, Gaziano JM, Cooper LS, Kim K, Solomon SD. High-dose influenza vaccine to reduce clinical outcomes in high-risk cardiovascular patients: Rationale and design of the INVESTED trial. Am Heart J. 2018 08; 202:97-103. PMID: 29909156.
    Citations: 5     Fields:    Translation:Humans
  18. Tong S, Zhang L, Joseph J, Jiang X. Celastrol pretreatment attenuates rat myocardial ischemia/ reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway. Biochem Biophys Res Commun. 2018 03 11; 497(3):843-849. PMID: 29475002.
    Citations: 5     Fields:    Translation:AnimalsCells
  19. Imran TF, Shin HJ, Mathenge N, Wang F, Kim B, Joseph J, Gaziano JM, Djoussé L. Meta-Analysis of the Usefulness of Plasma Galectin-3 to Predict the Risk of Mortality in Patients With Heart Failure and in the General Population. Am J Cardiol. 2017 Jan 01; 119(1):57-64. PMID: 28247849.
    Citations: 12     Fields:    Translation:Humans
  20. Sridharan V, Thomas CJ, Cao M, Melnyk SB, Pavliv O, Joseph J, Singh SP, Sharma S, Moros EG, Boerma M. Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart. Radiother Oncol. 2016 05; 119(2):259-64. PMID: 27072940.
    Citations: 6     Fields:    Translation:AnimalsCells
  21. McMurray JJ, Krum H, Abraham WT, Dickstein K, Køber LV, Desai AS, Solomon SD, Greenlaw N, Ali MA, Chiang Y, Shao Q, Tarnesby G, Massie BM. Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure. N Engl J Med. 2016 Apr 21; 374(16):1521-32. PMID: 27043774.
    Citations: 40     Fields:    Translation:Humans
  22. Joseph J, Claggett BC, Anand IS, Fleg JL, Huynh T, Desai AS, Solomon SD, O'Meara E, Mckinlay S, Pitt B, Pfeffer MA, Lewis EF. QRS Duration Is a Predictor of Adverse Outcomes in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2016 06; 4(6):477-86. PMID: 27039126.
    Citations: 6     Fields:    Translation:Humans
  23. Imran TF, Shah R, Ha AS, Thomas R, Joseph J. Heart failure associated with small molecule tyrosine kinase inhibitors. Int J Cardiol. 2016 Mar 01; 206:110-1. PMID: 26785036.
    Citations:    Fields:    Translation:Humans
  24. Church KM, Henalt R, Baker E, Smith GL, Brennan MT, Joseph J. Comparison of metoprolol succinate versus carvedilol in time to cardiovascular admission in a Veterans Affairs healthcare system: An observational study. Am J Health Syst Pharm. 2015 Dec 01; 72(23 Suppl 3):S183-90. PMID: 26582307.
    Citations:    Fields:    Translation:Humans
  25. Joseph J, Loscalzo J. Nutri(meta)genetics and cardiovascular disease: novel concepts in the interaction of diet and genomic variation. Curr Atheroscler Rep. 2015 May; 17(5):505. PMID: 25782777.
    Citations: 4     Fields:    Translation:Humans
  26. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014 Sep 11; 371(11):993-1004. PMID: 25176015.
    Citations: 655     Fields:    Translation:Humans
  27. Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Harty B, Heitner JF, Kenwood CT, Lewis EF, O'Meara E, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, Yang S, McKinlay SM. Spironolactone for heart failure with preserved ejection fraction. N Engl J Med. 2014 Apr 10; 370(15):1383-92. PMID: 24716680.
    Citations: 327     Fields:    Translation:Humans
  28. Forman DE, Daniels KM, Cahalin LP, Zavin A, Allsup K, Cao P, Santhanam M, Joseph J, Arena R, Lazzari A, Schulze PC, Lecker SH. Analysis of skeletal muscle gene expression patterns and the impact of functional capacity in patients with systolic heart failure. J Card Fail. 2014 Jun; 20(6):422-30. PMID: 24704539.
    Citations: 10     Fields:    Translation:Humans
  29. Joseph J. Needling the heart to rejuvenate: the promise of intramyocardial injection of bone marrow stem cells. J Heart Lung Transplant. 2014 Jun; 33(6):565-6. PMID: 24726425.
    Citations: 1     Fields:    Translation:HumansCells
  30. Zhi H, Luptak I, Alreja G, Shi J, Guan J, Metes-Kosik N, Joseph J. Effects of direct Renin inhibition on myocardial fibrosis and cardiac fibroblast function. PLoS One. 2013; 8(12):e81612. PMID: 24349097.
    Citations: 7     Fields:    Translation:AnimalsCells
  31. Sharma S, Joseph J, Chonchol M, Kaufman JS, Cheung AK, Rafeq Z, Smits G, Kendrick J. Higher fibroblast growth factor-23 concentrations associate with left ventricular systolic dysfunction in dialysis patients. Clin Nephrol. 2013 Nov; 80(5):313-21. PMID: 23849306.
    Citations: 6     Fields:    Translation:Humans
  32. Joseph J. Selenium and cardiometabolic health: inconclusive yet intriguing evidence. Am J Med Sci. 2013 Sep; 346(3):216-20. PMID: 22990046.
    Citations: 3     Fields:    Translation:HumansAnimals
  33. Joseph J, Loscalzo J. Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology. Nutrients. 2013 Aug 15; 5(8):3235-56. PMID: 23955381.
    Citations: 15     Fields:    Translation:HumansCells
  34. Daniels KM, Zavin A, Allsup K, Joseph J, Arena R, Lazzari AA, Schulze PC, Lecker SH, Brown J, Forman DE. Serum adiponectin in non-cachectic heart failure patients. Int J Cardiol. 2013 Oct 09; 168(4):4363-4. PMID: 23739548.
    Citations:    Fields:    Translation:Humans
  35. Joseph J, Loscalzo J. Selenistasis: epistatic effects of selenium on cardiovascular phenotype. Nutrients. 2013 Jan 31; 5(2):340-58. PMID: 23434902.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  36. Metes-Kosik N, Luptak I, Dibello PM, Handy DE, Tang SS, Zhi H, Qin F, Jacobsen DW, Loscalzo J, Joseph J. Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. Mol Nutr Food Res. 2012 Dec; 56(12):1812-24. PMID: 23097236.
    Citations: 16     Fields:    Translation:AnimalsCells
  37. Lecker SH, Zavin A, Cao P, Arena R, Allsup K, Daniels KM, Joseph J, Schulze PC, Forman DE. Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure. Circ Heart Fail. 2012 Nov; 5(6):812-8. PMID: 23001918.
    Citations: 48     Fields:    Translation:Humans
  38. Rafeq Z, Roh JD, Guarino P, Kaufman J, Joseph J. Adverse myocardial effects of B-vitamin therapy in subjects with chronic kidney disease and hyperhomocysteinaemia. Nutr Metab Cardiovasc Dis. 2013 Sep; 23(9):836-42. PMID: 22902185.
    Citations: 3     Fields:    Translation:Humans
  39. Zavin A, Daniels K, Arena R, Allsup K, Lazzari A, Joseph J, Schulze PC, Lecker SH, Forman DE. Adiposity facilitates increased strength capacity in heart failure patients with reduced ejection fraction. Int J Cardiol. 2013 Sep 10; 167(6):2468-71. PMID: 22743190.
    Citations: 9     Fields:    Translation:Humans
  40. Zavin A, Arena R, Joseph J, Allsup K, Daniels K, Schulze PC, Lecker S, Forman DE. Dynamic assessment of ventilatory efficiency during recovery from peak exercise to enhance cardiopulmonary exercise testing. Eur J Prev Cardiol. 2013 Oct; 20(5):779-85. PMID: 22517928.
    Citations: 1     Fields:    Translation:Humans
  41. Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J. Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol. 2012 Mar; 52(3):753-60. PMID: 22227328.
    Citations: 32     Fields:    Translation:AnimalsCells
  42. Sharma GV, Woods PA, Lindsey N, O'Connell C, Connolly L, Joseph J, McIntyre KM. Noninvasive monitoring of left ventricular end-diastolic pressure reduces rehospitalization rates in patients hospitalized for heart failure: a randomized controlled trial. J Card Fail. 2011 Sep; 17(9):718-25. PMID: 21872140.
    Citations: 6     Fields:    Translation:Humans
  43. Joseph J. Fattening by deprivation: methyl balance and perinatal cardiomyopathy. J Pathol. 2011 Nov; 225(3):315-7. PMID: 21735445.
    Citations: 2     Fields:    Translation:Animals
  44. Alreja G, Joseph J. Renin and cardiovascular disease: Worn-out path, or new direction. World J Cardiol. 2011 Mar 26; 3(3):72-83. PMID: 21499495.
    Citations: 1     
  45. Finch JM, Joseph J. Homocysteine, cardiovascular inflammation, and myocardial remodeling. Cardiovasc Hematol Disord Drug Targets. 2010 Dec 01; 10(4):241-5. PMID: 20932268.
    Citations: 7     Fields:    Translation:HumansAnimals
  46. Joseph J. A master of versatility to the heart's rescue: mast cells and ischemic preconditioning. Circulation. 2010 Aug 24; 122(8):761-3. PMID: 20697024.
    Citations:    Fields:    Translation:HumansAnimalsCells
  47. Aslam F, Haque A, Haque J, Joseph J. Heart failure in subjects with chronic kidney disease: Best management practices. World J Cardiol. 2010 May 26; 2(5):112-7. PMID: 21160712.
    Citations: 2     
  48. Mast Cells and Cardiovascular Disease. J Joseph (Editor). 2010.
  49. Joseph J, Pencina MJ, Wang TJ, Hayes L, Tofler GH, Jacques P, Selhub J, Levy D, D'Agostino RB, Benjamin EJ, Vasan RS. Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. J Hypertens. 2009 Jun; 27(6):1317-24. PMID: 19357531.
    Citations: 5     Fields:    Translation:Humans
  50. Joseph J, Handy DE, Loscalzo J. Quo vadis: whither homocysteine research? Cardiovasc Toxicol. 2009 Jun; 9(2):53-63. PMID: 19484390.
    Citations: 19     Fields:    Translation:HumansAnimals
  51. Joseph J, Joseph L, Devi S, Kennedy RH. Effect of anti-oxidant treatment on hyperhomocysteinemia-induced myocardial fibrosis and diastolic dysfunction. J Heart Lung Transplant. 2008 Nov; 27(11):1237-41. PMID: 18971097.
    Citations: 11     Fields:    Translation:Animals
  52. Jacob Joseph, Paulette Mehta, Asem Rimawi, Michele Cottler-Fox, Anjan Sinha, Balkrishna Mansingh, Eugene S. Smith III, Jawahar L. Mehta . Eur Heart J Suppl. Stem cell mobilization utilizing granulocyte colony stimulating factor in advanced chronic heart failure: lessons from a pilot study. 2008; suppl K(10):K24-K26 .
  53. Rajaram V, Joseph J. Role of adenosine antagonism in the cardio-renal syndrome: pathophysiology and therapeutic potential. Curr Heart Fail Rep. 2007 Sep; 4(3):153-7. PMID: 17883991.
    Citations: 1     Fields:    Translation:HumansAnimals
  54. Joseph J. The stem cell army in heart failure: do we mobilize or pave the way home? Eur Heart J. 2007 May; 28(10):1180-1. PMID: 17483525.
    Citations:    Fields:    Translation:HumansCells
  55. Boerma M, Fiser WP, Hoyt G, Berry GJ, Joseph L, Joseph J, Wang J, Crew MD, Robbins RC, Hauer-Jensen M. Influence of mast cells on outcome after heterotopic cardiac transplantation in rats. Transpl Int. 2007 Mar; 20(3):256-65. PMID: 17291219.
    Citations: 14     Fields:    Translation:AnimalsCells
  56. Herrmann W, Herrmann M, Joseph J, Tyagi SC. Homocysteine, brain natriuretic peptide and chronic heart failure: a critical review. Clin Chem Lab Med. 2007; 45(12):1633-44. PMID: 18067448.
    Citations: 7     Fields:    Translation:HumansAnimals
  57. Kennedy RH, Owings R, Joseph J, Melchert RB, Hauer-Jensen M, Boerma M. Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker. Clin Exp Pharmacol Physiol. 2006 Apr; 33(4):340-4. PMID: 16620298.
    Citations: 2     Fields:    Translation:Animals
  58. Devi S, Kennedy RH, Joseph L, Shekhawat NS, Melchert RB, Joseph J. Effect of long-term hyperhomocysteinemia on myocardial structure and function in hypertensive rats. Cardiovasc Pathol. 2006 Mar-Apr; 15(2):75-82. PMID: 16533695.
    Citations: 12     Fields:    Translation:Animals
  59. Toor AA, Ramdane BA, Joseph J, Thomas M, O'Hara C, Barlogie B, Walker P, Joseph L. Cardiac nonamyloidotic immunoglobulin deposition disease. Mod Pathol. 2006 Feb; 19(2):233-7. PMID: 16341150.
    Citations: 9     Fields:    Translation:Humans
  60. Joseph J, Rimawi A, Mehta P, Cottler-Fox M, Sinha A, Singh BK, Pacheco R, Smith ES, Mehta JL. Safety and effectiveness of granulocyte-colony stimulating factor in mobilizing stem cells and improving cytokine profile in advanced chronic heart failure. Am J Cardiol. 2006 Mar 01; 97(5):681-4. PMID: 16490437.
    Citations: 6     Fields:    Translation:HumansCells
  61. Kennedy RH, Melchert RB, Joseph J. Cardiovascular effects of hyperhomocysteinemia in conscious unrestrained rats. Am J Hypertens. 2006 Jan; 19(1):94-7. PMID: 16461198.
    Citations: 3     Fields:    Translation:Animals
  62. Boerma M, Wang J, Wondergem J, Joseph J, Qiu X, Kennedy RH, Hauer-Jensen M. Influence of mast cells on structural and functional manifestations of radiation-induced heart disease. Cancer Res. 2005 Apr 15; 65(8):3100-7. PMID: 15833839.
    Citations: 21     Fields:    Translation:AnimalsCellsPHPublic Health
  63. Bansal D, Gaddam V, Aude YW, Bissett J, Fahdi I, Garza L, Joseph J, Molavi B, Pai BV, Sinha A, Smith ES, Mehta JL. Trends in the care of patients with acute myocardial infarction at a university-affiliated Veterans Affairs Medical Center. J Cardiovasc Pharmacol Ther. 2005 Mar; 10(1):39-44. PMID: 15821837.
    Citations: 1     Fields:    Translation:Humans
  64. Maris ME, Melchert RB, Joseph J, Kennedy RH. Gender differences in blood pressure and heart rate in spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Pharmacol Physiol. 2005 Jan-Feb; 32(1-2):35-9. PMID: 15730432.
    Citations: 13     Fields:    Translation:Animals
  65. Joseph J, Kennedy RH, Devi S, Wang J, Joseph L, Hauer-Jensen M. Protective role of mast cells in homocysteine-induced cardiac remodeling. . 2005 May; 288(5):H2541-5. PMID: 15591099.
    Citations: 10     Translation:AnimalsCells
  66. Chen K, Mehta JL, Li D, Joseph L, Joseph J. Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II. Circ Res. 2004 Dec 10; 95(12):1167-73. PMID: 15539634.
    Citations: 43     Fields:    Translation:AnimalsCells
  67. Taylor AL, Ziesche S, Yancy C, Carson P, D'Agostino R, Ferdinand K, Taylor M, Adams K, Sabolinski M, Worcel M, Cohn JN. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004 Nov 11; 351(20):2049-57. PMID: 15533851.
    Citations: 270     Fields:    Translation:HumansCTClinical Trials
  68. Kennedy RH, Hauer-Jensen M, Joseph J. Cardiac function in hearts isolated from a rat model deficient in mast cells. . 2005 Feb; 288(2):H632-7. PMID: 15388501.
    Citations: 3     Translation:AnimalsCells
  69. Gattis WA, O'Connor CM, Gallup DS, Hasselblad V, Gheorghiade M. Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial. J Am Coll Cardiol. 2004 May 05; 43(9):1534-41. PMID: 15120808.
    Citations: 49     Fields:    Translation:HumansCTClinical Trials
  70. Joseph J, Washington A, Joseph L, Kennedy RH. Hyperhomocysteinaemia-induced atrial remodelling in hypertensive rats. Clin Exp Pharmacol Physiol. 2004 May-Jun; 31(5-6):331-7. PMID: 15191407.
    Citations:    Fields:    Translation:Animals
  71. Gheorghiade M, Gattis WA, O'Connor CM, Adams KF, Elkayam U, Barbagelata A, Ghali JK, Benza RL, McGrew FA, Klapholz M, Ouyang J, Orlandi C. Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial. JAMA. 2004 Apr 28; 291(16):1963-71. PMID: 15113814.
    Citations: 136     Fields:    Translation:HumansCTClinical Trials
  72. Kennedy RH, Owings R, Shekhawat N, Joseph J. Acute negative inotropic effects of homocysteine are mediated via the endothelium. . 2004 Aug; 287(2):H812-7. PMID: 15072957.
    Citations: 6     Translation:Animals
  73. Pfeffer MA, McMurray JJ, Velazquez EJ, Rouleau JL, Køber L, Maggioni AP, Solomon SD, Swedberg K, Van de Werf F, White H, Leimberger JD, Henis M, Edwards S, Zelenkofske S, Sellers MA, Califf RM. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003 Nov 13; 349(20):1893-906. PMID: 14610160.
    Citations: 378     Fields:    Translation:HumansCTClinical Trials
  74. Shi J, Wang J, Zheng H, Ling W, Joseph J, Li D, Mehta JL, Ponnappan U, Lin P, Fink LM, Hauer-Jensen M. Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. Blood Coagul Fibrinolysis. 2003 Sep; 14(6):575-85. PMID: 12960612.
    Citations: 30     Fields:    Translation:HumansCells
  75. Chahoud G, Joseph J. Beta-blockade in chronic heart failure: does it work in everyone? Curr Opin Cardiol. 2003 Sep; 18(5):400-5. PMID: 12960474.
    Citations:    Fields:    Translation:Humans
  76. Joseph J, Ranganathan S, Mehta JL. Low density lipoproteins modulate collagen metabolism in fibroblasts. J Cardiovasc Pharmacol Ther. 2003 Jun; 8(2):161-6. PMID: 12808489.
    Citations:    Fields:    Translation:HumansCells
  77. Joseph J, Joseph L. Hyperhomocysteinemia and cardiovascular disease: new mechanisms beyond atherosclerosis. Metab Syndr Relat Disord. 2003 Jun; 1(2):97-104. PMID: 18370631.
    Citations: 5     Fields:    
  78. Joseph J, Joseph L, Shekhawat NS, Devi S, Wang J, Melchert RB, Hauer-Jensen M, Kennedy RH. Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats. . 2003 Aug; 285(2):H679-86. PMID: 12730062.
    Citations: 25     Translation:Animals
  79. Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, Bittman R, Hurley S, Kleiman J, Gatlin M. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003 Apr 03; 348(14):1309-21. PMID: 12668699.
    Citations: 791     Fields:    Translation:HumansCTClinical Trials
  80. Ranganathan S, Joseph J, Mehta JL. Aspirin inhibits human coronary artery endothelial cell proliferation by upregulation of p53. Biochem Biophys Res Commun. 2003 Jan 31; 301(1):143-6. PMID: 12535653.
    Citations: 2     Fields:    Translation:HumansCells
  81. Singh BK, Joseph J and Mehta JL. . In: Theroux P (Ed). Acute Coronary Syndromes: A Companion to Braunwald’s Heart Disease. Nitrates and Nitric Oxide donors. 2003; 331-340.
  82. Joseph J, Li D, Chen H and Mehta JL. . In: Pierce GN, Nagano N, Zahradka P and Dhalla NS (Eds). Atherosclerosis, Hypertension and Diabetes. Identification, regulation and function of LOX-1, a novel receptor for Ox-LDL. 2003; 71-81.
  83. Joseph J, Trehan S and Taylor DO. In: Franco KL and Verrier ED (Eds). Advanced Therapy in Cardiac Surgery. Advances in Immunosuppression. 2003; 570-579.
  84. Joseph J, Washington A, Joseph L, Koehler L, Fink LM, Hauer-Jensen M, Kennedy RH. Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats. . 2002 Dec; 283(6):H2567-74. PMID: 12388235.
    Citations: 18     Translation:Animals
  85. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Trupp RJ, Underwood J, Pickering F, Truex C, McAtee P, Messenger J. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002 Jun 13; 346(24):1845-53. PMID: 12063368.
    Citations: 767     Fields:    Translation:HumansCTClinical Trials
  86. Melchert RB, Joseph J, Kennedy RH. Interaction of xenobiotics with myocardial signal transduction pathways. Cardiovasc Toxicol. 2002; 2(1):1-23. PMID: 12189277.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  87. Joseph J, Saucedo J and Talley JD. J Interv Cardiol. News & Views. (Editorial). 2000; 13(1):73-76.
  88. Slight SH, Joseph J, Ganjam VK, Weber KT. Extra-adrenal mineralocorticoids and cardiovascular tissue. J Mol Cell Cardiol. 1999 Jun; 31(6):1175-84. PMID: 10371693.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  89. Joseph J, Saucedo J and Talley JD. . J Interv Cardiol. News and Views (Editorial). 1999; 12(5):397-400.
  90. Joseph J, Saucedo J and Talley JD. . J Interv Cardiol. News and Views (Editorial). 1999; 12(4):321-324.
  91. Joseph J, Saucedo J and Talley JD. J Interv Cardiol. News and Views (Editorial). 1999; 12(3):227-230.
  92. Joseph J, Saucedo J and Talley JD. J Interv Cardiol. News and Views. (Editorial). 1999; 12(2):165-168.
  93. Joseph J, Saucedo J and Talley JD. J Interv Cardiol. News and Views. (Editorial). 1999; 12(1):95-98.
  94. Joseph J, Gilbert EM. The sympathetic nervous system in chronic heart failure. Prog Cardiovasc Dis. 1998 Jul-Aug; 41(1 Suppl 1):9-16. PMID: 9715818.
    Citations: 2     Fields:    Translation:HumansAnimals
  95. Joseph J, Trehan S and Taylor DO. In: Franco KL and Verrier ED (Eds). Advanced Therapy in Cardiac Surgery. Advances in Immunosuppression. 1998.
  96. Joseph J, Kandala JC, Veerapanane D, Weber KT, Guntaka RV. Antiparallel polypurine phosphorothioate oligonucleotides form stable triplexes with the rat alpha1(I) collagen gene promoter and inhibit transcription in cultured rat fibroblasts. Nucleic Acids Res. 1997 Jun 01; 25(11):2182-8. PMID: 9153319.
    Citations: 20     Fields:    Translation:AnimalsCells
  97. Abhayambika K, Girija G, Joseph J. A case of Holt Oram syndrome. Indian Heart J. 1991 Jan-Feb; 43(1):59-60. PMID: 1894307.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.