Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Jacob Joseph, M.B.,B.S., M.D.

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Overview
As the Director, Heart Failure Program at Veterans Affairs (VA) Boston Healthcare System, Dr. Joseph has championed the comprehensive care of veterans with heart failure in New England for more than 15 years. His successful efforts at implementing multidisciplinary patient centered care for heart failure has led to consistently outstanding outcomes at VA Boston with significantly lower 30-day mortality compared to the national average. Dr. Joseph initiated an institutional policy to admit all patients with a primary diagnosis of heart failure to Cardiology inpatient services, to abolish any racial inequity of care delivery. Currently, he leads a new initiative that will offer mechanical circulatory support and, in collaboration with Brigham and Women's Hospital, heart transplant, to veterans with advanced heart failure in the Northeastern United States. Under his leadership, the Heart Failure Program has expanded with the addition of the BWH-VA Advanced Heart Failure and Transplant Fellowship Program and has also added new faculty. Dr. Joseph leads several innovative clinical initiatives such as the creation and implementation of a novel Heart Failure dashboard that allows the monitoring of care at the patient level as well as overall population metrics. He is also leading an effort to implement pharmacogenomic testing in the outpatient cardiovascular clinics. Dr. Joseph has advised VA Medical Centers across the nation on building heart failure and advanced heart failure programs and lectured nationally and internationally on heart failure. He has served on national committees such as the Congestive Heart Failure Clinician Steering Committee of the University HealthSystem Consortium, Development Committee of the Heart Failure Society of America, and the Veterans Affairs COVID 19 Vaccine: High Risk Stakeholder Group.


Dr. Joseph has conducted translational research in heart failure utilizing a novel model of myocardial fibrosis which has received the 2020 Tinsley Harrison Award for Best Publication in the American Journal of Medical Sciences. His current research interests include the use of electronic medical records (EMR) for phenomic and genomic science and leading clinical trials in the National VA Healthcare System. He is the Clinical Sites Core Co-PI and VA Network PI for PREVENTABLE, VA Network PI for PROMINENT, and VA Network Co-PI for GALACTIC and INVESTED multicenter trials. Dr. Joseph will also lead the VA Network for LOFT-HF trial. In addition to providing leadership to these pivotal trials as the VA Network PI and member of Executive and Steering committees, Dr. Joseph is also engaged in research on EMR-enabled pragmatic methodologies in clinical trials such as site-specific recruitment lists and the capture of clinical trial endpoints from EMR. Utilizing the EMR to phenotype heart failure and undertake real world research to further epidemiologic and therapeutic understanding and risk prediction is a major aspect of Dr. Joseph’s research. As an Investigator in the Million Veteran Program, Dr. Joseph is utilizing the phenomic knowledge to perform genomic and other -omic analyses to further understand the genetic architecture and pathophysiology of heart failure. Dr. Joseph is also engaged in testing novel approaches to heart failure management as a multiple PI of a 3 site clinical trial on repurposing probenecid for the treatment of heart failure with reduced ejection fraction and PI of a clinical trial testing the utility of blood volume assessment in managing decompensated heart failure. He has published over 100 papers and has lectured nationally and internationally. Dr. Joseph is an Associate Editor of Cardiovascular Toxicology and an Executive Editor of the Journal of Physiology and Biochemistry, and serves on the Advisory Board for the American College of Cardiology - Medscape Center of Excellence in Heart Failure. He has also served as a member of the Scientific Advisory Committee and the Cardiovascular Disease Evidence Review Panel for NASA sponsored Radiation Research Programs.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. I01CX001968 (RUBINSTEIN, JACK) Jan 1, 2021 - Dec 31, 2026
    NIH
    Treatment of Veterans with Heart Failure with Reduced Ejection Fraction with Probenecid
    Role: Co-Principal Investigator
  2. I01 CX001968 (RUBINSTEIN, JACK; WU, WEN-CHIH; JOSEPH, JACOB) Jan 1, 2021 - Dec 31, 2025
    VA
    Re-purposing Probenecid for the Treatment of Heart Failure with Reduced Ejection Fraction. The Re-Prosper HF study
    Role Description: This drug repurposing study examines the safety and efficacy of probenecid, a generic drug used for treatment of gout, in HFrEF. Probenecid is an agonist of the Transient Receptor Superfamily Vanilloid 2 subtype that modulates myocyte contractility by increasing calcium cycling.
    Role: Multiple PI
  3. U19AG065188 (ALEXANDER, KAREN P) Sep 30, 2019 - Aug 31, 2026
    NIH
    PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)
    Role Description: The clinical sites core is a partnership between the National Patient-Centered Research Network (PCORnet) and the VA network (MAVERIC) combining approximately 35 health care systems and 60 VA hospitals with an eligible participant base of over 1.5 million older adults without dementia (including Alzheimer’s disease) or CVD. The clinical sites will randomize 20,000 diverse older US participants to determine the role of a moderate-intensity statin in preventing dementia, including Alzheimer’s disease, and prolonging disability-free survival in patients 75 years and older without clinically evident coronary heart disease, including those with frailty, impaired physical function, mild cognitive impairment, polypharmacy, and multi-morbidity. Sites will have a richly diverse US demographic including rural and urban areas (including Puerto Rico), some with over 50% minority participants. Start-up will be rapid, requiring engagement before randomization. Therefore, the pre-existing partnership and extant infrastructure between will position us well. The PCORnet and VA network/MAVERIC have a common data model against which electronic health record (EHR) data have been standardized, and have already provide data on eligible using the PREVENTABLE computable phenotype. PCORnet sites have negotiated terms for data sharing and other agreements, and have all executed single (SMART) IRB agreements and the VA network will use the VA IRB (NIH policy based exception). The clinical sites core will be under the leadership of Dr. Adrian Hernandez, PI of the PCORnet coordinating center and the NIH’s Health System Collaboratory and Dr. Jacob Joseph, PI of the MAVERIC research infrastructure. PCORnet and VA leaders have identified qualified and experienced potential site PIs and vetted proposed site payment and enrollment targets. During the protocol development year, ‘trailblazer’ sites, those with the largest pool of eligible participants and best performance in pragmatic trials, will set the stage for other sites. Performance during start-up, enrollment, data collection, and close-out will be monitored in real-time, and transparently shared across the study sites in the spirit of continuous quality improvement. Sites that do not meet pre-established performance metrics will be supported by local network leads and Steering Committee representatives, as well as from the Recruitment Core. The clinical site core specific aims are: AIM 1. Select and activate high-performing sites across 40 PCORnet health care systems and 60 hospitals in the VA Network/MAVERIC to randomize 20,000 diverse older US participants through an established partnership with proven success in pragmatic trial conduct. AIM 2. Socialize a broad group of health care systems in support of the trial hypothesis, and incentivize engagement by ensuring adequate funding, rewarding academic contributions, engaging local research structures (OAIC/Pepper Centers, GRECC, CTSA), and limiting site burden to sustain interest and the net value of participation. AIM 3. Actively monitor and transparently share randomization rates, data quality, and responsiveness to central queries and take corrective actions to address barriers and share best practices for pragmatic trial conduct.
    Role: Co-PI of Clinical Sites Core and PI of VA Network
  4. I01CX001922 (JOSEPH, JACOB) Jul 1, 2019 - Jun 30, 2023
    NIH
    Pragmatic Approaches to Capture and Ascertainment of Clinical Trial Endpoints
    Role Description: The aim of this VA-funded project is to develop methods to capture clinical trial endpoints from electronic medical records( EMR) and compare EMR based capture to traditional methods of endpoint capture and ascertainment
    Role: Principal Investigator
  5. I01CX001737 (PHILLIPS, LAWRENCE S) Oct 1, 2018 - Sep 30, 2020
    NIH
    Diabetic Complications and Genetic Variants in the Million Veterans Program
    Role Description: The project targets discovery of new genetic variants that should help to improve the healthcare of adults with diabetes. The effects of genetic variants on the risk of incident heart failure with preserved and reduced ejection fraction and on outcomes in heart failure will be examined in the context of diabetes as a risk factor.
    Role: Co-Investigator and lead of Heart Failure Genomics

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Huang S, Cai T, Weber BN, He Z, Dahal KP, Hong C, Hou J, Seyok T, Cagan A, DiCarli MF, Joseph J, Kim SC, Solomon DH, Cai T, Liao KP. The Association Between Inflammation, Incident Heart Failure, and Heart Failure Subtypes in Patients with Rheumatoid Arthritis. Arthritis Care Res. 2021. View Publication.
  2. Handy DE, Joseph J, Loscalzo J. Selenium, a Micronutrient That Modulates Cardiovascular Health via Redox Enzymology. Nutrients. 2021 Sep 17; 13(9). PMID: 34579115.
    Citations:    Fields:    
  3. Gaziano L, Cho K, Djousse L, Schubert P, Galloway A, Ho YL, Kurgansky K, Gagnon DR, Russo JP, Di Angelantonio E, Wood AM, Danesh J, Gaziano JM, Butterworth AS, Wilson PWF, Joseph J. Risk factors and prediction models for incident heart failure with reduced and preserved ejection fraction. ESC Heart Fail. 2021 Sep 16. PMID: 34528757.
    Citations:    Fields:    
  4. Yuyun MF, Erqou SA, Peralta AO, Hoffmeister PS, Yarmohammadi H, Echouffo Tcheugui JB, Martin DT, Joseph J, Singh JP. Risk of ventricular arrhythmia in cardiac resynchronization therapy responders and super-responders: a systematic review and meta-analysis. Europace. 2021 08 06; 23(8):1262-1274. PMID: 33496319.
    Citations: 1     Fields:    Translation:Humans
  5. Parker MM, Damrauer SM, Tcheandjieu C, Erbe D, Aldinc E, Hawkins PN, Gillmore JD, Hull LE, Lynch JA, Joseph J, Ticau S, Flynn-Carroll AO, Deaton AM, Ward LD, Assimes TL, Tsao PS, Chang KM, Rader DJ, Fitzgerald K, Vaishnaw AK, Hinkle G, Nioi P. Association of the transthyretin variant V122I with polyneuropathy among individuals of African ancestry. Sci Rep. 2021 06 02; 11(1):11645. PMID: 34079032.
    Citations:    Fields:    
  6. Bhatt AS, Vardeny O, Udell JA, Joseph J, Kim K, Solomon SD. Influenza vaccination: a 'shot' at INVESTing in cardiovascular health. Eur Heart J. 2021 05 21; 42(20):2015-2018. PMID: 33748833.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  7. Gaziano L, Giambartolomei C, Pereira AC, Gaulton A, Posner DC, Swanson SA, Ho YL, Iyengar SK, Kosik NM, Vujkovic M, Gagnon DR, Bento AP, Barrio-Hernandez I, Rönnblom L, Hagberg N, Lundtoft C, Langenberg C, Pietzner M, Valentine D, Gustincich S, Tartaglia GG, Allara E, Surendran P, Burgess S, Zhao JH, Peters JE, Prins BP, Angelantonio ED, Devineni P, Shi Y, Lynch KE, DuVall SL, Garcon H, Thomann LO, Zhou JJ, Gorman BR, Huffman JE, O'Donnell CJ, Tsao PS, Beckham JC, Pyarajan S, Muralidhar S, Huang GD, Ramoni R, Beltrao P, Danesh J, Hung AM, Chang KM, Sun YV, Joseph J, Leach AR, Edwards TL, Cho K, Gaziano JM, Butterworth AS, Casas JP. Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19. Nat Med. 2021 04; 27(4):668-676. PMID: 33837377.
    Citations: 5     Fields:    Translation:Humans
  8. Almufleh A, Joseph J. The time is now: role of pragmatic clinical trials in guiding response to global pandemics. Trials. 2021 Mar 24; 22(1):229. PMID: 33761968.
    Citations: 2     Fields:    Translation:Humans
  9. Joseph J. Is there a purpose to medicine? J Eval Clin Pract. 2021 06; 27(3):665-666. PMID: 33755274.
    Citations: 1     Fields:    Translation:Humans
  10. Joseph J, Giczewska A, Alhanti B, Cheema AK, Handy DE, Mann DL, Loscalzo J, Givertz MM. Associations of methyl donor and methylation inhibitor levels during anti-oxidant therapy in heart failure. J Physiol Biochem. 2021 May; 77(2):295-304. PMID: 33595776.
    Citations:    Fields:    Translation:HumansCells
  11. Yuyun MF, Erqou SA, Peralta AO, Hoffmeister PS, Yarmohammadi H, Echouffo-Tcheugui JB, Martin DT, Joseph J, Singh JP. Ongoing Risk of Ventricular Arrhythmias and All-Cause Mortality at Implantable Cardioverter Defibrillator Generator Change: A Systematic Review and Meta-Analysis. Circ Arrhythm Electrophysiol. 2021 03; 14(3):e009139. PMID: 33554611.
    Citations:    Fields:    Translation:Humans
  12. Rasalingam R, Parker R, Kurgansky KE, Djousse L, Gagnon D, Joseph J. Worsening Renal Function during Index Hospitalization Does Not Predict Prognosis in Heart Failure with Preserved Ejection Fraction Patients. Cardiology. 2021; 146(2):179-186. PMID: 33524973.
    Citations:    Fields:    Translation:Humans
  13. Vardeny O, Kim K, Udell JA, Joseph J, Desai AS, Farkouh ME, Hegde SM, Hernandez AF, McGeer A, Talbot HK, Anand I, Bhatt DL, Cannon CP, DeMets D, Gaziano JM, Goodman SG, Nichol K, Tattersall MC, Temte JL, Wittes J, Yancy C, Claggett B, Chen Y, Mao L, Havighurst TC, Cooper LS, Solomon SD. Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular Disease: A Randomized Clinical Trial. JAMA. 2021 01 05; 325(1):39-49. PMID: 33275134.
    Citations: 7     Fields:    Translation:Humans
  14. Patel Y, Joseph J. Sodium Intake and Heart Failure. Int J Mol Sci. 2020 Dec 13; 21(24). PMID: 33322108.
    Citations: 2     Fields:    Translation:Humans
  15. Joseph J. Life's irreducible structure: Where are we, five decades later? Bioessays. 2021 01; 43(1):e2000250. PMID: 33169412.
    Citations:    Fields:    
  16. Vaduganathan M, van Meijgaard J, Mehra MR, Joseph J, O'Donnell CJ, Warraich HJ. Prescription Fill Patterns for Commonly Used Drugs During the COVID-19 Pandemic in the United States. JAMA. 2020 06 23; 323(24):2524-2526. PMID: 32463459.
    Citations: 34     Fields:    Translation:HumansCellsPHPublic Health
  17. Foster M, Albanese C, Chen Q, Sethares KA, Evans S, Lehmann LS, Spencer J, Joseph J. Heart Failure Dashboard Design and Validation to Improve Care of Veterans. Appl Clin Inform. 2020 01; 11(1):153-159. PMID: 32102107.
    Citations: 2     Fields:    Translation:Humans
  18. Kurgansky KE, Schubert P, Parker R, Djousse L, Riebman JB, Gagnon DR, Joseph J. Association of pulse rate with outcomes in heart failure with reduced ejection fraction: a retrospective cohort study. BMC Cardiovasc Disord. 2020 02 26; 20(1):92. PMID: 32101141.
    Citations: 1     Fields:    Translation:Humans
  19. Banerjee A, Allan V, Denaxas S, Shah A, Kotecha D, Lambiase PD, Joseph J, Lund LH, Hemingway H. Subtypes of atrial fibrillation with concomitant valvular heart disease derived from electronic health records: phenotypes, population prevalence, trends and prognosis. Europace. 2019 12 01; 21(12):1776-1784. PMID: 31408153.
    Citations: 4     Fields:    Translation:Humans
  20. Djoussé L, Cook NR, Kim E, Bodar V, Walter J, Bubes V, Luttmann-Gibson H, Mora S, Joseph J, Lee IM, Albert CM, Buring JE, Gaziano JM, Manson JE. Supplementation With Vitamin D and Omega-3 Fatty Acids and Incidence of Heart Failure Hospitalization: VITAL-Heart Failure. Circulation. 2020 03 03; 141(9):784-786. PMID: 31709816.
    Citations: 6     Fields:    Translation:Humans
  21. Metra M, Teerlink JR, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Pang PS, Ponikowski P, Voors AA, Adams KF, Anker SD, Arias-Mendoza A, Avendaño P, Bacal F, Böhm M, Bortman G, Cleland JGF, Cohen-Solal A, Crespo-Leiro MG, Dorobantu M, Echeverría LE, Ferrari R, Goland S, Goncalvesová E, Goudev A, Køber L, Lema-Osores J, Levy PD, McDonald K, Manga P, Merkely B, Mueller C, Pieske B, Silva-Cardoso J, Špinar J, Squire I, Stepinska J, Van Mieghem W, von Lewinski D, Wikström G, Yilmaz MB, Hagner N, Holbro T, Hua TA, Sabarwal SV, Severin T, Szecsödy P, Gimpelewicz C. Effects of Serelaxin in Patients with Acute Heart Failure. N Engl J Med. 2019 08 22; 381(8):716-726. PMID: 31433919.
    Citations: 32     Fields:    Translation:Humans
  22. Tong S, Zhang L, Joseph J, Jiang X. A novel, potential therapeutic target in diabetic cardiomyocytes: ROCK2. Int J Cardiol. 2019 08 01; 288:121. PMID: 30948216.
    Citations: 2     Fields:    Translation:HumansCells
  23. Imran TF, Kurgansky KE, Patel YR, Orkaby AR, McLean RR, Ho YL, Cho K, Gaziano JM, Djousse L, Gagnon DR, Joseph J. Serial sodium values and adverse outcomes in heart failure with preserved ejection fraction. Int J Cardiol. 2019 09 01; 290:119-124. PMID: 30929975.
    Citations: 2     Fields:    Translation:Humans
  24. Joseph J. Orchestrating Metabolic Flexibility: PGC-1a and Clinical Heart Failure. Am J Med Sci. 2019 04; 357(4):273-274. PMID: 30711188.
    Citations: 2     Fields:    Translation:Humans
  25. Zhang L, Joseph L, Joseph J. In Vivo and In Vitro Effects of Vasopressin V2 Receptor Antagonism on Myocardial Fibrosis in Rats. Am J Med Sci. 2019 02; 357(2):151-159. PMID: 30665496.
    Citations:    Fields:    Translation:Animals
  26. Tong S, Zhang L, Joseph J. Letter by Tong et al Regarding Article, "Efficacy and Safety of the Use of Non-Vitamin K Antagonist Oral Anticoagulants in Patients With Nonvalvular Atrial Fibrillation and Concomitant Aspirin Therapy: A Meta-Analysis of Randomized Trials". Circulation. 2018 09 18; 138(12):1277-1278. PMID: 30354435.
    Citations:    Fields:    Translation:Humans
  27. Tong S, Zhang L, Joseph J, Jiang X. A potential and novel therapeutic approach to ischemic heart failure: Algisyl-LVR. Int J Cardiol. 2018 11 15; 271:209. PMID: 30100223.
    Citations: 1     Fields:    Translation:Humans
  28. Patel YR, Robbins JM, Kurgansky KE, Imran T, Orkaby AR, McLean RR, Ho YL, Cho K, Michael Gaziano J, Djousse L, Gagnon DR, Joseph J. Development and validation of a heart failure with preserved ejection fraction cohort using electronic medical records. BMC Cardiovasc Disord. 2018 06 28; 18(1):128. PMID: 29954337.
    Citations: 6     Fields:    Translation:Humans
  29. Patel YR, Kurgansky KE, Imran TF, Orkaby AR, McLean RR, Ho YL, Cho K, Gaziano JM, Djousse L, Gagnon DR, Joseph J. Prognostic Significance of Baseline Serum Sodium in Heart Failure With Preserved Ejection Fraction. J Am Heart Assoc. 2018 06 13; 7(12). PMID: 29899018.
    Citations: 3     Fields:    Translation:Humans
  30. Srivastava A, Do JM, Sales VL, Ly S, Joseph J. Impact of patient-centred home telehealth programme on outcomes in heart failure. J Telemed Telecare. 2019 Aug; 25(7):425-430. PMID: 29793388.
    Citations: 4     Fields:    Translation:Humans
  31. Vardeny O, Udell JA, Joseph J, Farkouh ME, Hernandez AF, McGeer AJ, Talbot HK, Bhatt DL, Cannon CP, Goodman SG, Anand I, DeMets DL, Temte J, Wittes J, Nichol K, Yancy CW, Gaziano JM, Cooper LS, Kim K, Solomon SD. High-dose influenza vaccine to reduce clinical outcomes in high-risk cardiovascular patients: Rationale and design of the INVESTED trial. Am Heart J. 2018 08; 202:97-103. PMID: 29909156.
    Citations: 8     Fields:    Translation:Humans
  32. Tong S, Zhang L, Joseph J, Jiang X. Celastrol pretreatment attenuates rat myocardial ischemia/ reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway. Biochem Biophys Res Commun. 2018 03 11; 497(3):843-849. PMID: 29475002.
    Citations: 9     Fields:    Translation:AnimalsCells
  33. Imran TF, Shin HJ, Mathenge N, Wang F, Kim B, Joseph J, Gaziano JM, Djoussé L. Meta-Analysis of the Usefulness of Plasma Galectin-3 to Predict the Risk of Mortality in Patients With Heart Failure and in the General Population. Am J Cardiol. 2017 Jan 01; 119(1):57-64. PMID: 28247849.
    Citations: 26     Fields:    Translation:Humans
  34. Sridharan V, Thomas CJ, Cao M, Melnyk SB, Pavliv O, Joseph J, Singh SP, Sharma S, Moros EG, Boerma M. Effects of local irradiation combined with sunitinib on early remodeling, mitochondria, and oxidative stress in the rat heart. Radiother Oncol. 2016 05; 119(2):259-64. PMID: 27072940.
    Citations: 8     Fields:    Translation:AnimalsCells
  35. McMurray JJ, Krum H, Abraham WT, Dickstein K, Køber LV, Desai AS, Solomon SD, Greenlaw N, Ali MA, Chiang Y, Shao Q, Tarnesby G, Massie BM. Aliskiren, Enalapril, or Aliskiren and Enalapril in Heart Failure. N Engl J Med. 2016 Apr 21; 374(16):1521-32. PMID: 27043774.
    Citations: 58     Fields:    Translation:Humans
  36. Joseph J, Claggett BC, Anand IS, Fleg JL, Huynh T, Desai AS, Solomon SD, O'Meara E, Mckinlay S, Pitt B, Pfeffer MA, Lewis EF. QRS Duration Is a Predictor of Adverse Outcomes in Heart Failure With Preserved Ejection Fraction. JACC Heart Fail. 2016 06; 4(6):477-86. PMID: 27039126.
    Citations: 10     Fields:    Translation:Humans
  37. Imran TF, Shah R, Ha AS, Thomas R, Joseph J. Heart failure associated with small molecule tyrosine kinase inhibitors. Int J Cardiol. 2016 Mar 01; 206:110-1. PMID: 26785036.
    Citations:    Fields:    Translation:Humans
  38. Church KM, Henalt R, Baker E, Smith GL, Brennan MT, Joseph J. Comparison of metoprolol succinate versus carvedilol in time to cardiovascular admission in a Veterans Affairs healthcare system: An observational study. Am J Health Syst Pharm. 2015 Dec 01; 72(23 Suppl 3):S183-90. PMID: 26582307.
    Citations:    Fields:    Translation:Humans
  39. Joseph J, Loscalzo J. Nutri(meta)genetics and cardiovascular disease: novel concepts in the interaction of diet and genomic variation. Curr Atheroscler Rep. 2015 May; 17(5):505. PMID: 25782777.
    Citations: 5     Fields:    Translation:Humans
  40. McMurray JJ, Packer M, Desai AS, Gong J, Lefkowitz MP, Rizkala AR, Rouleau JL, Shi VC, Solomon SD, Swedberg K, Zile MR. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med. 2014 Sep 11; 371(11):993-1004. PMID: 25176015.
    Citations: 1084     Fields:    Translation:Humans
  41. Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Harty B, Heitner JF, Kenwood CT, Lewis EF, O'Meara E, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, Yang S, McKinlay SM. Spironolactone for heart failure with preserved ejection fraction. N Engl J Med. 2014 Apr 10; 370(15):1383-92. PMID: 24716680.
    Citations: 479     Fields:    Translation:Humans
  42. Forman DE, Daniels KM, Cahalin LP, Zavin A, Allsup K, Cao P, Santhanam M, Joseph J, Arena R, Lazzari A, Schulze PC, Lecker SH. Analysis of skeletal muscle gene expression patterns and the impact of functional capacity in patients with systolic heart failure. J Card Fail. 2014 Jun; 20(6):422-30. PMID: 24704539.
    Citations: 11     Fields:    Translation:Humans
  43. Joseph J. Needling the heart to rejuvenate: the promise of intramyocardial injection of bone marrow stem cells. J Heart Lung Transplant. 2014 Jun; 33(6):565-6. PMID: 24726425.
    Citations: 1     Fields:    Translation:HumansCells
  44. Zhi H, Luptak I, Alreja G, Shi J, Guan J, Metes-Kosik N, Joseph J. Effects of direct Renin inhibition on myocardial fibrosis and cardiac fibroblast function. PLoS One. 2013; 8(12):e81612. PMID: 24349097.
    Citations: 9     Fields:    Translation:AnimalsCells
  45. Sharma S, Joseph J, Chonchol M, Kaufman JS, Cheung AK, Rafeq Z, Smits G, Kendrick J. Higher fibroblast growth factor-23 concentrations associate with left ventricular systolic dysfunction in dialysis patients. Clin Nephrol. 2013 Nov; 80(5):313-21. PMID: 23849306.
    Citations: 6     Fields:    Translation:Humans
  46. Joseph J. Selenium and cardiometabolic health: inconclusive yet intriguing evidence. Am J Med Sci. 2013 Sep; 346(3):216-20. PMID: 22990046.
    Citations: 5     Fields:    Translation:HumansAnimals
  47. Joseph J, Loscalzo J. Methoxistasis: integrating the roles of homocysteine and folic acid in cardiovascular pathobiology. Nutrients. 2013 Aug 15; 5(8):3235-56. PMID: 23955381.
    Citations: 21     Fields:    Translation:HumansCells
  48. Daniels KM, Zavin A, Allsup K, Joseph J, Arena R, Lazzari AA, Schulze PC, Lecker SH, Brown J, Forman DE. Serum adiponectin in non-cachectic heart failure patients. Int J Cardiol. 2013 Oct 09; 168(4):4363-4. PMID: 23739548.
    Citations:    Fields:    Translation:Humans
  49. Joseph J, Loscalzo J. Selenistasis: epistatic effects of selenium on cardiovascular phenotype. Nutrients. 2013 Jan 31; 5(2):340-58. PMID: 23434902.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  50. Metes-Kosik N, Luptak I, Dibello PM, Handy DE, Tang SS, Zhi H, Qin F, Jacobsen DW, Loscalzo J, Joseph J. Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. Mol Nutr Food Res. 2012 Dec; 56(12):1812-24. PMID: 23097236.
    Citations: 21     Fields:    Translation:AnimalsCells
  51. Lecker SH, Zavin A, Cao P, Arena R, Allsup K, Daniels KM, Joseph J, Schulze PC, Forman DE. Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure. Circ Heart Fail. 2012 Nov; 5(6):812-8. PMID: 23001918.
    Citations: 61     Fields:    Translation:Humans
  52. Rafeq Z, Roh JD, Guarino P, Kaufman J, Joseph J. Adverse myocardial effects of B-vitamin therapy in subjects with chronic kidney disease and hyperhomocysteinaemia. Nutr Metab Cardiovasc Dis. 2013 Sep; 23(9):836-42. PMID: 22902185.
    Citations: 5     Fields:    Translation:Humans
  53. Zavin A, Daniels K, Arena R, Allsup K, Lazzari A, Joseph J, Schulze PC, Lecker SH, Forman DE. Adiposity facilitates increased strength capacity in heart failure patients with reduced ejection fraction. Int J Cardiol. 2013 Sep 10; 167(6):2468-71. PMID: 22743190.
    Citations: 9     Fields:    Translation:Humans
  54. Zavin A, Arena R, Joseph J, Allsup K, Daniels K, Schulze PC, Lecker S, Forman DE. Dynamic assessment of ventilatory efficiency during recovery from peak exercise to enhance cardiopulmonary exercise testing. Eur J Prev Cardiol. 2013 Oct; 20(5):779-85. PMID: 22517928.
    Citations: 2     Fields:    Translation:Humans
  55. Wang X, Cui L, Joseph J, Jiang B, Pimental D, Handy DE, Liao R, Loscalzo J. Homocysteine induces cardiomyocyte dysfunction and apoptosis through p38 MAPK-mediated increase in oxidant stress. J Mol Cell Cardiol. 2012 Mar; 52(3):753-60. PMID: 22227328.
    Citations: 34     Fields:    Translation:AnimalsCells
  56. Sharma GV, Woods PA, Lindsey N, O'Connell C, Connolly L, Joseph J, McIntyre KM. Noninvasive monitoring of left ventricular end-diastolic pressure reduces rehospitalization rates in patients hospitalized for heart failure: a randomized controlled trial. J Card Fail. 2011 Sep; 17(9):718-25. PMID: 21872140.
    Citations: 6     Fields:    Translation:Humans
  57. Joseph J. Fattening by deprivation: methyl balance and perinatal cardiomyopathy. J Pathol. 2011 Nov; 225(3):315-7. PMID: 21735445.
    Citations: 2     Fields:    Translation:Animals
  58. Alreja G, Joseph J. Renin and cardiovascular disease: Worn-out path, or new direction. World J Cardiol. 2011 Mar 26; 3(3):72-83. PMID: 21499495.
    Citations: 3     
  59. Cervellin G, Comelli I, Comelli D, Cortellini P, Lippi G, Meschi T, Borghi L. Regional short-term climate variations influence on the number of visits for renal colic in a large urban Emergency Department: results of a 7-year survey. Intern Emerg Med. 2011 Apr; 6(2):141-7. PMID: 21249474.
    Citations: 6     Fields:    Translation:Humans
  60. Finch JM, Joseph J. Homocysteine, cardiovascular inflammation, and myocardial remodeling. Cardiovasc Hematol Disord Drug Targets. 2010 Dec 01; 10(4):241-5. PMID: 20932268.
    Citations: 7     Fields:    Translation:HumansAnimals
  61. Joseph J. A master of versatility to the heart's rescue: mast cells and ischemic preconditioning. Circulation. 2010 Aug 24; 122(8):761-3. PMID: 20697024.
    Citations:    Fields:    Translation:HumansAnimalsCells
  62. Aslam F, Haque A, Haque J, Joseph J. Heart failure in subjects with chronic kidney disease: Best management practices. World J Cardiol. 2010 May 26; 2(5):112-7. PMID: 21160712.
    Citations: 2     
  63. Mast Cells and Cardiovascular Disease. J Joseph (Editor). 2010.
  64. Joseph J, Pencina MJ, Wang TJ, Hayes L, Tofler GH, Jacques P, Selhub J, Levy D, D'Agostino RB, Benjamin EJ, Vasan RS. Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community. J Hypertens. 2009 Jun; 27(6):1317-24. PMID: 19357531.
    Citations: 5     Fields:    Translation:Humans
  65. Joseph J, Handy DE, Loscalzo J. Quo vadis: whither homocysteine research? Cardiovasc Toxicol. 2009 Jun; 9(2):53-63. PMID: 19484390.
    Citations: 20     Fields:    Translation:HumansAnimals
  66. Joseph J, Joseph L, Devi S, Kennedy RH. Effect of anti-oxidant treatment on hyperhomocysteinemia-induced myocardial fibrosis and diastolic dysfunction. J Heart Lung Transplant. 2008 Nov; 27(11):1237-41. PMID: 18971097.
    Citations: 12     Fields:    Translation:Animals
  67. Jacob Joseph, Paulette Mehta, Asem Rimawi, Michele Cottler-Fox, Anjan Sinha, Balkrishna Mansingh, Eugene S. Smith III, Jawahar L. Mehta . Eur Heart J Suppl. Stem cell mobilization utilizing granulocyte colony stimulating factor in advanced chronic heart failure: lessons from a pilot study. 2008; suppl K(10):K24-K26 .
  68. Rajaram V, Joseph J. Role of adenosine antagonism in the cardio-renal syndrome: pathophysiology and therapeutic potential. Curr Heart Fail Rep. 2007 Sep; 4(3):153-7. PMID: 17883991.
    Citations: 2     Fields:    Translation:HumansAnimals
  69. Joseph J. The stem cell army in heart failure: do we mobilize or pave the way home? Eur Heart J. 2007 May; 28(10):1180-1. PMID: 17483525.
    Citations:    Fields:    Translation:HumansCells
  70. Boerma M, Fiser WP, Hoyt G, Berry GJ, Joseph L, Joseph J, Wang J, Crew MD, Robbins RC, Hauer-Jensen M. Influence of mast cells on outcome after heterotopic cardiac transplantation in rats. Transpl Int. 2007 Mar; 20(3):256-65. PMID: 17291219.
    Citations: 14     Fields:    Translation:AnimalsCells
  71. Herrmann W, Herrmann M, Joseph J, Tyagi SC. Homocysteine, brain natriuretic peptide and chronic heart failure: a critical review. Clin Chem Lab Med. 2007; 45(12):1633-44. PMID: 18067448.
    Citations: 7     Fields:    Translation:HumansAnimals
  72. Kennedy RH, Owings R, Joseph J, Melchert RB, Hauer-Jensen M, Boerma M. Acute dilatory and negative inotropic effects of homocysteine are inhibited by an adenosine blocker. Clin Exp Pharmacol Physiol. 2006 Apr; 33(4):340-4. PMID: 16620298.
    Citations: 2     Fields:    Translation:Animals
  73. Devi S, Kennedy RH, Joseph L, Shekhawat NS, Melchert RB, Joseph J. Effect of long-term hyperhomocysteinemia on myocardial structure and function in hypertensive rats. Cardiovasc Pathol. 2006 Mar-Apr; 15(2):75-82. PMID: 16533695.
    Citations: 13     Fields:    Translation:Animals
  74. Toor AA, Ramdane BA, Joseph J, Thomas M, O'Hara C, Barlogie B, Walker P, Joseph L. Cardiac nonamyloidotic immunoglobulin deposition disease. Mod Pathol. 2006 Feb; 19(2):233-7. PMID: 16341150.
    Citations: 9     Fields:    Translation:Humans
  75. Joseph J, Rimawi A, Mehta P, Cottler-Fox M, Sinha A, Singh BK, Pacheco R, Smith ES, Mehta JL. Safety and effectiveness of granulocyte-colony stimulating factor in mobilizing stem cells and improving cytokine profile in advanced chronic heart failure. Am J Cardiol. 2006 Mar 01; 97(5):681-4. PMID: 16490437.
    Citations: 6     Fields:    Translation:HumansCells
  76. Kennedy RH, Melchert RB, Joseph J. Cardiovascular effects of hyperhomocysteinemia in conscious unrestrained rats. Am J Hypertens. 2006 Jan; 19(1):94-7. PMID: 16461198.
    Citations: 3     Fields:    Translation:Animals
  77. Boerma M, Wang J, Wondergem J, Joseph J, Qiu X, Kennedy RH, Hauer-Jensen M. Influence of mast cells on structural and functional manifestations of radiation-induced heart disease. Cancer Res. 2005 Apr 15; 65(8):3100-7. PMID: 15833839.
    Citations: 25     Fields:    Translation:AnimalsCellsPHPublic Health
  78. Bansal D, Gaddam V, Aude YW, Bissett J, Fahdi I, Garza L, Joseph J, Molavi B, Pai BV, Sinha A, Smith ES, Mehta JL. Trends in the care of patients with acute myocardial infarction at a university-affiliated Veterans Affairs Medical Center. J Cardiovasc Pharmacol Ther. 2005 Mar; 10(1):39-44. PMID: 15821837.
    Citations: 1     Fields:    Translation:Humans
  79. Maris ME, Melchert RB, Joseph J, Kennedy RH. Gender differences in blood pressure and heart rate in spontaneously hypertensive and Wistar-Kyoto rats. Clin Exp Pharmacol Physiol. 2005 Jan-Feb; 32(1-2):35-9. PMID: 15730432.
    Citations: 14     Fields:    Translation:Animals
  80. Joseph J, Kennedy RH, Devi S, Wang J, Joseph L, Hauer-Jensen M. Protective role of mast cells in homocysteine-induced cardiac remodeling. . 2005 May; 288(5):H2541-5. PMID: 15591099.
    Citations: 13     Translation:AnimalsCells
  81. Chen K, Mehta JL, Li D, Joseph L, Joseph J. Transforming growth factor beta receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II. Circ Res. 2004 Dec 10; 95(12):1167-73. PMID: 15539634.
    Citations: 49     Fields:    Translation:AnimalsCells
  82. Taylor AL, Ziesche S, Yancy C, Carson P, D'Agostino R, Ferdinand K, Taylor M, Adams K, Sabolinski M, Worcel M, Cohn JN. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. N Engl J Med. 2004 Nov 11; 351(20):2049-57. PMID: 15533851.
    Citations: 304     Fields:    Translation:HumansCTClinical Trials
  83. Kennedy RH, Hauer-Jensen M, Joseph J. Cardiac function in hearts isolated from a rat model deficient in mast cells. . 2005 Feb; 288(2):H632-7. PMID: 15388501.
    Citations: 3     Translation:AnimalsCells
  84. Gattis WA, O'Connor CM, Gallup DS, Hasselblad V, Gheorghiade M. Predischarge initiation of carvedilol in patients hospitalized for decompensated heart failure: results of the Initiation Management Predischarge: Process for Assessment of Carvedilol Therapy in Heart Failure (IMPACT-HF) trial. J Am Coll Cardiol. 2004 May 05; 43(9):1534-41. PMID: 15120808.
    Citations: 65     Fields:    Translation:HumansCTClinical Trials
  85. Joseph J, Washington A, Joseph L, Kennedy RH. Hyperhomocysteinaemia-induced atrial remodelling in hypertensive rats. Clin Exp Pharmacol Physiol. 2004 May-Jun; 31(5-6):331-7. PMID: 15191407.
    Citations:    Fields:    Translation:Animals
  86. Gheorghiade M, Gattis WA, O'Connor CM, Adams KF, Elkayam U, Barbagelata A, Ghali JK, Benza RL, McGrew FA, Klapholz M, Ouyang J, Orlandi C. Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial. JAMA. 2004 Apr 28; 291(16):1963-71. PMID: 15113814.
    Citations: 145     Fields:    Translation:HumansCTClinical Trials
  87. Kennedy RH, Owings R, Shekhawat N, Joseph J. Acute negative inotropic effects of homocysteine are mediated via the endothelium. . 2004 Aug; 287(2):H812-7. PMID: 15072957.
    Citations: 7     Translation:Animals
  88. Pfeffer MA, McMurray JJ, Velazquez EJ, Rouleau JL, Køber L, Maggioni AP, Solomon SD, Swedberg K, Van de Werf F, White H, Leimberger JD, Henis M, Edwards S, Zelenkofske S, Sellers MA, Califf RM. Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med. 2003 Nov 13; 349(20):1893-906. PMID: 14610160.
    Citations: 421     Fields:    Translation:HumansCTClinical Trials
  89. Shi J, Wang J, Zheng H, Ling W, Joseph J, Li D, Mehta JL, Ponnappan U, Lin P, Fink LM, Hauer-Jensen M. Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. Blood Coagul Fibrinolysis. 2003 Sep; 14(6):575-85. PMID: 12960612.
    Citations: 31     Fields:    Translation:HumansCells
  90. Chahoud G, Joseph J. Beta-blockade in chronic heart failure: does it work in everyone? Curr Opin Cardiol. 2003 Sep; 18(5):400-5. PMID: 12960474.
    Citations:    Fields:    Translation:Humans
  91. Joseph J, Ranganathan S, Mehta JL. Low density lipoproteins modulate collagen metabolism in fibroblasts. J Cardiovasc Pharmacol Ther. 2003 Jun; 8(2):161-6. PMID: 12808489.
    Citations:    Fields:    Translation:HumansCells
  92. Joseph J, Joseph L. Hyperhomocysteinemia and cardiovascular disease: new mechanisms beyond atherosclerosis. Metab Syndr Relat Disord. 2003 Jun; 1(2):97-104. PMID: 18370631.
    Citations: 6     Fields:    
  93. Joseph J, Joseph L, Shekhawat NS, Devi S, Wang J, Melchert RB, Hauer-Jensen M, Kennedy RH. Hyperhomocysteinemia leads to pathological ventricular hypertrophy in normotensive rats. . 2003 Aug; 285(2):H679-86. PMID: 12730062.
    Citations: 27     Translation:Animals
  94. Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, Bittman R, Hurley S, Kleiman J, Gatlin M. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003 Apr 03; 348(14):1309-21. PMID: 12668699.
    Citations: 895     Fields:    Translation:HumansCTClinical Trials
  95. Ranganathan S, Joseph J, Mehta JL. Aspirin inhibits human coronary artery endothelial cell proliferation by upregulation of p53. Biochem Biophys Res Commun. 2003 Jan 31; 301(1):143-6. PMID: 12535653.
    Citations: 2     Fields:    Translation:HumansCells
  96. Singh BK, Joseph J and Mehta JL. . In: Theroux P (Ed). Acute Coronary Syndromes: A Companion to Braunwald’s Heart Disease. Nitrates and Nitric Oxide donors. 2003; 331-340.
  97. Joseph J, Li D, Chen H and Mehta JL. . In: Pierce GN, Nagano N, Zahradka P and Dhalla NS (Eds). Atherosclerosis, Hypertension and Diabetes. Identification, regulation and function of LOX-1, a novel receptor for Ox-LDL. 2003; 71-81.
  98. Joseph J, Trehan S and Taylor DO. In: Franco KL and Verrier ED (Eds). Advanced Therapy in Cardiac Surgery. Advances in Immunosuppression. 2003; 570-579.
  99. Joseph J, Washington A, Joseph L, Koehler L, Fink LM, Hauer-Jensen M, Kennedy RH. Hyperhomocysteinemia leads to adverse cardiac remodeling in hypertensive rats. . 2002 Dec; 283(6):H2567-74. PMID: 12388235.
    Citations: 18     Translation:Animals
  100. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Trupp RJ, Underwood J, Pickering F, Truex C, McAtee P, Messenger J. Cardiac resynchronization in chronic heart failure. N Engl J Med. 2002 Jun 13; 346(24):1845-53. PMID: 12063368.
    Citations: 848     Fields:    Translation:HumansCTClinical Trials
  101. Melchert RB, Joseph J, Kennedy RH. Interaction of xenobiotics with myocardial signal transduction pathways. Cardiovasc Toxicol. 2002; 2(1):1-23. PMID: 12189277.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  102. Joseph J, Saucedo J and Talley JD. J Interv Cardiol. News & Views. (Editorial). 2000; 13(1):73-76.
  103. Slight SH, Joseph J, Ganjam VK, Weber KT. Extra-adrenal mineralocorticoids and cardiovascular tissue. J Mol Cell Cardiol. 1999 Jun; 31(6):1175-84. PMID: 10371693.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  104. Joseph J, Saucedo J and Talley JD. . J Interv Cardiol. News and Views (Editorial). 1999; 12(5):397-400.
  105. Joseph J, Saucedo J and Talley JD. . J Interv Cardiol. News and Views (Editorial). 1999; 12(4):321-324.
  106. Joseph J, Saucedo J and Talley JD. J Interv Cardiol. News and Views (Editorial). 1999; 12(3):227-230.
  107. Joseph J, Saucedo J and Talley JD. J Interv Cardiol. News and Views. (Editorial). 1999; 12(2):165-168.
  108. Joseph J, Saucedo J and Talley JD. J Interv Cardiol. News and Views. (Editorial). 1999; 12(1):95-98.
  109. Joseph J, Gilbert EM. The sympathetic nervous system in chronic heart failure. Prog Cardiovasc Dis. 1998 Jul-Aug; 41(1 Suppl 1):9-16. PMID: 9715818.
    Citations: 2     Fields:    Translation:HumansAnimals
  110. Joseph J, Trehan S and Taylor DO. In: Franco KL and Verrier ED (Eds). Advanced Therapy in Cardiac Surgery. Advances in Immunosuppression. 1998.
  111. Joseph J, Kandala JC, Veerapanane D, Weber KT, Guntaka RV. Antiparallel polypurine phosphorothioate oligonucleotides form stable triplexes with the rat alpha1(I) collagen gene promoter and inhibit transcription in cultured rat fibroblasts. Nucleic Acids Res. 1997 Jun 01; 25(11):2182-8. PMID: 9153319.
    Citations: 20     Fields:    Translation:AnimalsCells
  112. Abhayambika K, Girija G, Joseph J. A case of Holt Oram syndrome. Indian Heart J. 1991 Jan-Feb; 43(1):59-60. PMID: 1894307.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.