Harvard Catalyst Profiles

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Charles E. Larsen, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. F32AI008117 (LARSEN, CHARLES E) Mar 31, 1990
    Role: Principal Investigator
  2. P01HL029583 (ALPER, CHESTER ALLAN) Jul 1, 1983 - Nov 30, 2006
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Vadva Z, Larsen CE, Propp BE, Trautwein MR, Alford DR, Alper CA. A New Pedigree-Based SNP Haplotype Method for Genomic Polymorphism and Genetic Studies. Cells. 2019 08 05; 8(8). PMID: 31387299; PMCID: PMC6721696.
    Citations: 4     Fields:    Translation:Humans
  2. Alper CA, Larsen CE, Trautwein MR, Alford DR. A stochastic epigenetic Mendelian oligogenic disease model for type 1 diabetes. J Autoimmun. 2019 01; 96:123-133. PMID: 30309752; PMCID: PMC6326579.
    Citations: 3     Fields:    Translation:Humans
  3. Alper CA, Larsen CE. Pedigree-Defined Haplotypes and Their Applications to Genetic Studies. Methods Mol Biol. 2017; 1551:113-127. PMID: 28138843.
    Citations: 6     Fields:    Translation:Humans
  4. Larsen CE, Alford DR, Trautwein MR, Jalloh YK, Tarnacki JL, Kunnenkeri SK, Fici DA, Yunis EJ, Awdeh ZL, Alper CA. Dominant sequences of human major histocompatibility complex conserved extended haplotypes from HLA-DQA2 to DAXX. PLoS Genet. 2014 Oct; 10(10):e1004637. PMID: 25299700; PMCID: PMC4191933.
    Citations: 13     Fields:    Translation:HumansCells
  5. Granados-Montiel J, Zúñiga J, Azocar J, Feris EJ, Terreros D, Larsen CE, Clavijo OP, Cruz-Lagunas A, Middleton D, Alper CA, Pandey JP, Yunis EJ. Interaction between immunoglobulin allotypes and NK receptor genes in diabetes post-hepatitis C virus infection. Immunobiology. 2011 Jun; 216(6):686-91. PMID: 21281981.
    Citations:    Fields:    Translation:HumansCells
  6. Szilágyi A, Bánlaki Z, Pozsonyi E, Yunis EJ, Awdeh ZL, Hossó A, Rajczy K, Larsen CE, Fici DA, Alper CA, Füst G. Frequent occurrence of conserved extended haplotypes (CEHs) in two Caucasian populations. Mol Immunol. 2010 Jun; 47(10):1899-904. PMID: 20409590.
    Citations: 6     Fields:    Translation:HumansCells
  7. Husain Z, Kelly MA, Eisenbarth GS, Pugliese A, Awdeh ZL, Larsen CE, Alper CA. The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1. J Autoimmun. 2008 Jun; 30(4):266-72. PMID: 18065200.
    Citations: 8     Fields:    Translation:HumansCells
  8. Romero V, Larsen CE, Duke-Cohan JS, Fox EA, Romero T, Clavijo OP, Fici DA, Husain Z, Almeciga I, Alford DR, Awdeh ZL, Zuñiga J, El-Dahdah L, Alper CA, Yunis EJ. Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E. BMC Genet. 2007 Apr 12; 8:14. PMID: 17430593; PMCID: PMC1853106.
    Citations: 12     Fields:    Translation:HumansCells
  9. Awdeh ZL, Yunis EJ, Audeh MJ, Fici D, Pugliese A, Larsen CE, Alper CA. A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease. J Autoimmun. 2006 Nov; 27(3):174-81. PMID: 17052889.
    Citations: 13     Fields:    Translation:HumansCells
  10. Alper CA, Husain Z, Larsen CE, Dubey DP, Stein R, Day C, Baker A, Beyan H, Hawa M, Ola TO, Leslie RD. Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type 1 diabetes. J Autoimmun. 2006 Sep; 27(2):89-95. PMID: 17029885; PMCID: PMC1810396.
    Citations: 14     Fields:    Translation:Humans
  11. Alper CA, Larsen CE, Dubey DP, Awdeh ZL, Fici DA, Yunis EJ. The haplotype structure of the human major histocompatibility complex. Hum Immunol. 2006 Jan-Feb; 67(1-2):73-84. PMID: 16698428.
    Citations: 44     Fields:    Translation:Humans
  12. Larsen CE, Alper CA. The genetics of HLA-associated disease. Curr Opin Immunol. 2004 Oct; 16(5):660-7. PMID: 15342014.
    Citations: 33     Fields:    Translation:HumansAnimals
  13. Pinto C, Smith AG, Larsen CE, Fernández-Viña M, Husain Z, Clavijo OP, Wang ZC, Nisperos B, Hansen JA, Alper CA, Yunis EJ. HLA-Cw*0409N is associated with HLA-A*2301 and HLA-B*4403-carrying haplotypes. Hum Immunol. 2004 Feb; 65(2):181-7. PMID: 14969773.
    Citations: 5     Fields:    Translation:HumansCells
  14. Alper CA, Xu J, Cosmopoulos K, Dolinski B, Stein R, Uko G, Larsen CE, Dubey DP, Densen P, Truedsson L, Sturfelt G, Sjöholm AG. Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency. J Clin Immunol. 2003 Jul; 23(4):297-305. PMID: 12959222.
    Citations: 10     Fields:    Translation:Humans
  15. Yunis EJ, Larsen CE, Fernandez-Viña M, Awdeh ZL, Romero T, Hansen JA, Alper CA. Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks. Tissue Antigens. 2003 Jul; 62(1):1-20. PMID: 12859592.
    Citations: 56     Fields:    Translation:HumansCells
  16. Crawford K, Stark A, Kitchens B, Sternheim K, Pantazopoulos V, Triantafellow E, Wang Z, Vasir B, Larsen CE, Gabuzda D, Reinherz E, Alper CA. CD2 engagement induces dendritic cell activation: implications for immune surveillance and T-cell activation. Blood. 2003 Sep 01; 102(5):1745-52. PMID: 12714509.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  17. Husain Z, Levitan E, Larsen CE, Mirza NM, Younes S, Yunis EJ, Alper CA, Dubey DP. HLA-Cw7 zygosity affects the size of a subset of CD158b+ natural killer cells. J Clin Immunol. 2002 Jan; 22(1):28-36. PMID: 11958591.
    Citations: 9     Fields:    Translation:HumansCells
  18. Uko GP, Fraser PA, Awdeh ZL, Fici DA, Crawford KD, Larsen CE, Alper CA. Hepatitis B surface antigen- and tetanus toxoid-specific clonal expansion of CD4+ cells in vitro determined by TCRBV CDR3 length and nucleotide sequence. Genes Immun. 2001 Feb; 2(1):11-9. PMID: 11294562.
    Citations: 1     Fields:    Translation:HumansCells
  19. Larsen CE, Xu J, Lee S, Dubey DP, Uko G, Yunis EJ, Alper CA. Complex cytokine responses to hepatitis B surface antigen and tetanus toxoid in responders, nonresponders and subjects naive to hepatitis B surface antigen. Vaccine. 2000 Jul 01; 18(26):3021-30. PMID: 10825606.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  20. Spragg DD, Alford DR, Greferath R, Larsen CE, Lee KD, Gurtner GC, Cybulsky MI, Tosi PF, Nicolau C, Gimbrone MA. Immunotargeting of liposomes to activated vascular endothelial cells: a strategy for site-selective delivery in the cardiovascular system. Proc Natl Acad Sci U S A. 1997 Aug 05; 94(16):8795-800. PMID: 9238057; PMCID: PMC23135.
    Citations: 43     Fields:    Translation:HumansCells
  21. Larsen CE, Nir S, Alford DR, Jennings M, Lee KD, Düzgünes N. Human immunodeficiency virus type 1 (HIV-1) fusion with model membranes: kinetic analysis and the role of lipid composition, pH and divalent cations. Biochim Biophys Acta. 1993 Apr 22; 1147(2):223-36. PMID: 8476916.
    Citations: 4     Fields:    Translation:HumansCells
  22. Düzgünes N, Larsen CE, Konopka K, Alford DR, Young LJ, McGraw TP, Davis BR, Nir S, Jennings M. Fusion of HIV-1 and SIVmac with liposomes and modulation of HIV-1 infectivity. Adv Exp Med Biol. 1991; 300:167-89; discussion 190-2. PMID: 1664176.
    Citations:    Fields:    Translation:HumansAnimalsCells
  23. Konopka K, Davis BR, Larsen CE, Alford DR, Debs RJ, Düzgünes N. Liposomes modulate human immunodeficiency virus infectivity. J Gen Virol. 1990 Dec; 71 ( Pt 12):2899-907. PMID: 2273389.
    Citations: 7     Fields:    Translation:HumansCells
  24. Larsen CE, Alford DR, Young LJ, McGraw TP, Düzgünes N. Fusion of simian immunodeficiency virus with liposomes and erythrocyte ghost membranes: effects of lipid composition, pH and calcium. J Gen Virol. 1990 Sep; 71 ( Pt 9):1947-55. PMID: 2120385.
    Citations: 2     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.