Harvard Catalyst Profiles

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Fumito Ichinose, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS116671 (ICHINOSE, FUMITO) May 1, 2020 - Apr 30, 2022
    Novel Antidotes for H2S Poisoning
    Role: Principal Investigator
  2. R01NS112373 (ICHINOSE, FUMITO) Jul 1, 2019 - Mar 31, 2024
    Role of sulfide catabolism in ischemic brain injury
    Role: Principal Investigator
  3. R01HL110378 (ICHINOSE, FUMITO) Apr 1, 2012 - Mar 31, 2016
    Improving Outcomes in Cardiac Arrest/CPR with Inhaled Nitric Oxide
    Role: Principal Investigator
  4. R01HL101930 (ICHINOSE, FUMITO) Apr 5, 2010 - Mar 31, 2015
    Role: Principal Investigator
  5. R01GM079360 (ICHINOSE, FUMITO) May 8, 2007 - Apr 30, 2013
    Impact of nitric oxide synthase on myocardial dysfunction of sepsis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Maron BA, Gladwin MT, Bonnet S, De Jesus Perez V, Perman SM, Yu PB, Ichinose F. Perspectives on Cardiopulmonary Critical Care for COVID-19 Patients: From Members of the American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation. J Am Heart Assoc. 2020 Jun 18; e017111. PMID: 32552164.
  2. Miyazaki Y, Ichinose F. Nitric Oxide in Post-cardiac Arrest Syndrome. J Cardiovasc Pharmacol. 2020 Jun; 75(6):508-515. PMID: 32421275.
  3. Marutani E, Ichinose F. Emerging pharmacological tools to control hydrogen sulfide signaling in critical illness. Intensive Care Med Exp. 2020 Jan 31; 8(1):5. PMID: 32006269.
  4. Patgiri A, Skinner OS, Miyazaki Y, Schleifer G, Marutani E, Shah H, Sharma R, Goodman RP, To TL, Robert Bao X, Ichinose F, Zapol WM, Mootha VK. An engineered enzyme that targets circulating lactate to alleviate intracellular NADH:NAD+ imbalance. Nat Biotechnol. 2020 03; 38(3):309-313. PMID: 31932725.
  5. Zazzeron L, Fischbach A, Franco W, Farinelli WA, Ichinose F, Bloch DB, Anderson RR, Zapol WM. Phototherapy and extracorporeal membrane oxygenation facilitate removal of carbon monoxide in rats. Sci Transl Med. 2019 10 09; 11(513). PMID: 31597752.
  6. Jain IH, Zazzeron L, Goldberger O, Marutani E, Wojtkiewicz GR, Ast T, Wang H, Schleifer G, Stepanova A, Brepoels K, Schoonjans L, Carmeliet P, Galkin A, Ichinose F, Zapol WM, Mootha VK. Leigh Syndrome Mouse Model Can Be Rescued by Interventions that Normalize Brain Hyperoxia, but Not HIF Activation. Cell Metab. 2019 10 01; 30(4):824-832.e3. PMID: 31402314.
  7. Hayashida K, Ichinose F. Response by Hayashida and Ichinose to Letter Regarding Article, "Improvement in Outcomes After Cardiac Arrest and Resuscitation by Inhibition of S-Nitrosoglutathione Reductase". Circulation. 2019 08 06; 140(6):e192-e193. PMID: 31381424.
  8. Yang CT, Wang Y, Marutani E, Ida T, Ni X, Xu S, Chen W, Zhang H, Akaike T, Ichinose F, Xian M. Data-Driven Identification of Hydrogen Sulfide Scavengers. Angew Chem Int Ed Engl. 2019 08 05; 58(32):10898-10902. PMID: 31194894.
  9. Marrazzo F, Spina S, Zadek F, Lama T, Xu C, Larson G, Rezoagli E, Malhotra R, Zheng H, Bittner EA, Shelton K, Melnitchouk S, Roy N, Sundt TM, Riley WD, Williams P, Fisher D, Kacmarek RM, Thompson TB, Bonventre J, Zapol W, Ichinose F, Berra L. Protocol of a randomised controlled trial in cardiac surgical patients with endothelial dysfunction aimed to prevent postoperative acute kidney injury by administering nitric oxide gas. BMJ Open. 2019 07 04; 9(7):e026848. PMID: 31278097.
  10. Ryzhov S, May T, Dziodzio J, Emery IF, Lucas FL, Leclerc A, McCrum B, Lord C, Eldridge A, Robich MP, Ichinose F, Sawyer DB, Riker R, Seder DB. Number of Circulating CD 73-Expressing Lymphocytes Correlates With Survival After Cardiac Arrest. J Am Heart Assoc. 2019 07 02; 8(13):e010874. PMID: 31237169.
  11. Petersen B, Busch CJ, Schleifer G, Schaack D, Lasitschka F, Bloch KD, Bloch DB, Ichinose F. Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia. Respir Res. 2019 Jun 03; 20(1):109. PMID: 31159807.
  12. Hayashida K, Miyazaki Y, Yu B, Silverman MG, Pinciroli R, Berra L, Malhotra R, Donnino MW, Ichinose F. Depletion of Vascular Nitric Oxide Contributes to Poor Outcomes after Cardiac Arrest. Am J Respir Crit Care Med. 2019 05 15; 199(10):1288-1290. PMID: 30785772.
  13. Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019 05 30; 177(6):1507-1521.e16. PMID: 31031004.
  14. Hayashida K, Bagchi A, Miyazaki Y, Hirai S, Seth D, Silverman MG, Rezoagli E, Marutani E, Mori N, Magliocca A, Liu X, Berra L, Hindle AG, Donnino MW, Malhotra R, Bradley MO, Stamler JS, Ichinose F. Improvement in Outcomes After Cardiac Arrest and Resuscitation by Inhibition of S-Nitrosoglutathione Reductase. Circulation. 2019 02 05; 139(6):815-827. PMID: 30586713.
    Citations:    Fields:    
  15. Marrazzo F, Larson G, Sherpa Lama TT, Teggia Droghi M, Joyce M, Ichinose F, Watkins MT, Stowell C, Crowley J, Berra L. Inhaled nitric oxide prevents systemic and pulmonary vasoconstriction due to hemoglobin-based oxygen carrier infusion: A case report. J Crit Care. 2019 06; 51:213-216. PMID: 30709560.
    Citations:    Fields:    
  16. Kakinohana M, Marutani E, Tokuda K, Kida K, Kosugi S, Kasamatsu S, Magliocca A, Ikeda K, Kai S, Sakaguchi M, Hirai S, Xian M, Kaneki M, Ichinose F. Breathing hydrogen sulfide prevents delayed paraplegia in mice. Free Radic Biol Med. 2019 02 01; 131:243-250. PMID: 30529602.
    Citations:    Fields:    
  17. Schleifer G, Marutani E, Ferrari M, Sharma R, Skinner O, Goldberger O, Grange RMH, Peneyra K, Malhotra R, Wepler M, Ichinose F, Bloch DB, Mootha VK, Zapol WM. Impaired hypoxic pulmonary vasoconstriction in a mouse model of Leigh syndrome. Am J Physiol Lung Cell Mol Physiol. 2019 02 01; 316(2):L391-L399. PMID: 30520688.
    Citations:    Fields:    
  18. Yu B, Ichinose F, Bloch DB, Zapol WM. Inhaled nitric oxide. Br J Pharmacol. 2019 01; 176(2):246-255. PMID: 30288739.
    Citations:    Fields:    
  19. Zapol WM, Charles HC, Martin AR, Sá RC, Yu B, Ichinose F, MacIntyre N, Mammarappallil J, Moon R, Chen JZ, Geier ET, Darquenne C, Prisk GK, Katz I. Pulmonary Delivery of Therapeutic and Diagnostic Gases. J Aerosol Med Pulm Drug Deliv. 2018 04; 31(2):78-87. PMID: 29451844.
    Citations:    Fields:    
  20. Magliocca A, Rezoagli E, Anderson TA, Burns SM, Ichinose F, Chitilian HV. Cardiac Output Measurements Based on the Pulse Wave Transit Time and Thoracic Impedance Exhibit Limited Agreement With Thermodilution Method During Orthotopic Liver Transplantation. Anesth Analg. 2018 01; 126(1):85-92. PMID: 28598912.
    Citations: 2     Fields:    Translation:Humans
  21. Ichinose F, Zapol WM. Inhaled Pulmonary Vasodilators in Cardiac Surgery Patients: Correct Answer Is "NO". Anesth Analg. 2017 08; 125(2):375-377. PMID: 28731972.
    Citations:    Fields:    Translation:Humans
  22. Hoeft K, Bloch DB, Graw JA, Malhotra R, Ichinose F, Bagchi A. Iron Loading Exaggerates the Inflammatory Response to the Toll-like Receptor 4 Ligand Lipopolysaccharide by Altering Mitochondrial Homeostasis. Anesthesiology. 2017 07; 127(1):121-135. PMID: 28430694.
    Citations: 1     Fields:    Translation:AnimalsCells
  23. Nagasaka Y, Wepler M, Thoonen R, Sips PY, Allen K, Graw JA, Yao V, Burns SM, Muenster S, Brouckaert P, Miller K, Solt K, Buys ES, Ichinose F, Zapol WM. Sensitivity to Sevoflurane anesthesia is decreased in mice with a congenital deletion of Guanylyl Cyclase-1 alpha. BMC Anesthesiol. 2017 06 14; 17(1):76. PMID: 28615047.
    Citations:    Fields:    Translation:Animals
  24. Wepler M, Beloiartsev A, Buswell MD, Panigrahy D, Malhotra R, Buys ES, Radermacher P, Ichinose F, Bloch DB, Zapol WM. Soluble epoxide hydrolase deficiency or inhibition enhances murine hypoxic pulmonary vasoconstriction after lipopolysaccharide challenge. Am J Physiol Lung Cell Mol Physiol. 2016 Dec 01; 311(6):L1213-L1221. PMID: 27815261.
    Citations: 1     Fields:    
  25. Bao XR, Ong SE, Goldberger O, Peng J, Sharma R, Thompson DA, Vafai SB, Cox AG, Marutani E, Ichinose F, Goessling W, Regev A, Carr SA, Clish CB, Mootha VK. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Elife. 2016 06 16; 5. PMID: 27307216.
    Citations: 36     Fields:    Translation:HumansCells
  26. Rezoagli E, Ichinose F, Strelow S, Roy N, Shelton K, Matsumine R, Chen L, Bittner EA, Bloch DB, Zapol WM, Berra L. Pulmonary and Systemic Vascular Resistances After Cardiopulmonary Bypass: Role of Hemolysis. J Cardiothorac Vasc Anesth. 2017 Apr; 31(2):505-515. PMID: 27590461.
    Citations: 1     Fields:    Translation:Humans
  27. Ikeda K, Liu X, Kida K, Marutani E, Hirai S, Sakaguchi M, Andersen LW, Bagchi A, Cocchi MN, Berg KM, Ichinose F, Donnino MW. Thiamine as a neuroprotective agent after cardiac arrest. Resuscitation. 2016 08; 105:138-44. PMID: 27185216.
    Citations: 3     Fields:    Translation:HumansAnimals
  28. Brücken A, Derwall M, Bleilevens C, Stoppe C, Götzenich A, Gaisa NT, Weis J, Nolte KW, Rossaint R, Ichinose F, Fries M. Brief inhalation of nitric oxide increases resuscitation success and improves 7-day-survival after cardiac arrest in rats: a randomized controlled animal study. Crit Care. 2015 Nov 17; 19:408. PMID: 26577797.
    Citations: 4     Fields:    Translation:Animals
  29. Marutani E, Yamada M, Ida T, Tokuda K, Ikeda K, Kai S, Shirozu K, Hayashida K, Kosugi S, Hanaoka K, Kaneki M, Akaike T, Ichinose F. Thiosulfate Mediates Cytoprotective Effects of Hydrogen Sulfide Against Neuronal Ischemia. J Am Heart Assoc. 2015 Nov 06; 4(11). PMID: 26546573.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  30. Derwall M, Ebeling A, Nolte KW, Weis J, Rossaint R, Ichinose F, Nix C, Fries M, Brücken A. Inhaled nitric oxide improves transpulmonary blood flow and clinical outcomes after prolonged cardiac arrest: a large animal study. Crit Care. 2015 Sep 15; 19:328. PMID: 26369409.
    Citations: 5     Fields:    Translation:Animals
  31. Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Jiramongkolchai P, Bloch DB, Doulias PT, Armoundas AA, Kaneki M, Ischiropoulos H, Kranias E, Bloch KD, Stamler JS, Ichinose F. S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. Circ Res. 2015 Oct 09; 117(9):793-803. PMID: 26259881.
    Citations: 9     Fields:    Translation:AnimalsCells
  32. Wang R, Szabo C, Ichinose F, Ahmed A, Whiteman M, Papapetropoulos A. The role of H2S bioavailability in endothelial dysfunction. Trends Pharmacol Sci. 2015 Sep; 36(9):568-78. PMID: 26071118.
    Citations: 17     Fields:    Translation:HumansAnimals
  33. Ikeda K, Marutani E, Hirai S, Wood ME, Whiteman M, Ichinose F. Mitochondria-targeted hydrogen sulfide donor AP39 improves neurological outcomes after cardiac arrest in mice. Nitric Oxide. 2015 Sep 15; 49:90-6. PMID: 25960429.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Peng B, Zhang C, Marutani E, Pacheco A, Chen W, Ichinose F, Xian M. Trapping hydrogen sulfide (H2S) with diselenides: the application in the design of fluorescent probes. Org Lett. 2015 Mar 20; 17(6):1541-4. PMID: 25723840.
    Citations: 1     Fields:    Translation:Cells
  35. Kida K, Ichinose F. Hydrogen Sulfide and Neuroinflammation. Handb Exp Pharmacol. 2015; 230:181-9. PMID: 26162835.
    Citations: 5     Fields:    Translation:HumansAnimals
  36. Zhang M, Zou L, Feng Y, Chen YJ, Zhou Q, Ichinose F, Chao W. Toll-like receptor 4 is essential to preserving cardiac function and survival in low-grade polymicrobial sepsis. Anesthesiology. 2014 Dec; 121(6):1270-80. PMID: 24937074.
    Citations: 6     Fields:    Translation:AnimalsCells
  37. Sakaguchi M, Marutani E, Shin HS, Chen W, Hanaoka K, Xian M, Ichinose F. Sodium thiosulfate attenuates acute lung injury in mice. Anesthesiology. 2014 Dec; 121(6):1248-57. PMID: 25260144.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  38. Shirozu K, Hirai S, Tanaka T, Hisaka S, Kaneki M, Ichinose F. Farnesyltransferase inhibitor, tipifarnib, prevents galactosamine/lipopolysaccharide-induced acute liver failure. Shock. 2014 Dec; 42(6):570-577. PMID: 25046541.
    Citations: 2     Fields:    Translation:AnimalsCells
  39. Kida K, Marutani E, Nguyen RK, Ichinose F. Inhaled hydrogen sulfide prevents neuropathic pain after peripheral nerve injury in mice. Nitric Oxide. 2015 Apr 30; 46:87-92. PMID: 25461302.
    Citations: 3     Fields:    Translation:AnimalsCells
  40. Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, Nakazawa H, Ichinose F, Yamada Y, Ishigami A, Ito H, Ouchi Y, Starr ME, Saito H, Shimokado K, Stamler JS, Kaneki M. Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65. Sci Signal. 2014 Nov 11; 7(351):ra106. PMID: 25389371.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  41. Marutani E, Sakaguchi M, Chen W, Sasakura K, Liu J, Xian M, Hanaoka K, Nagano T, Ichinose F. Cytoprotective effects of hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonists are mediated by intracellular sulfane sulfur. Medchemcomm. 2014 Oct 01; 5(10):1577-1583. PMID: 25431645.
    Citations: 4     
  42. Kida K, Shirozu K, Yu B, Mandeville JB, Bloch KD, Ichinose F. Beneficial effects of nitric oxide on outcomes after cardiac arrest and cardiopulmonary resuscitation in hypothermia-treated mice. Anesthesiology. 2014 Apr; 120(4):880-9. PMID: 24496125.
    Citations: 13     Fields:    Translation:Animals
  43. Kida K, Ichinose F. Preventing ischemic brain injury after sudden cardiac arrest using NO inhalation. Crit Care. 2014 Mar 18; 18(2):212. PMID: 25029464.
    Citations: 1     Fields:    Translation:HumansAnimals
  44. Fitzsimons MG, Ichinose F, Vagefi PA, Markmann JF, Pierce ET, MacGillivray TE, Hertl M, Gauran C, Madsen JC, Baker J. Successful right ventricular mechanical support after combined heart-liver transplantation. J Cardiothorac Vasc Anesth. 2014 Dec; 28(6):1583-5. PMID: 24462515.
    Citations:    Fields:    Translation:Humans
  45. Shirozu K, Tokuda K, Marutani E, Lefer DJ, Wang R, Ichinose F. OP05 Cystathionine ?-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure. Nitric Oxide. 2013 Sep 1; 31 Suppl 2:S21. PMID: 24948244.
  46. Shirozu K, Tokuda K, Marutani E, Lefer D, Wang R, Ichinose F. Cystathionine ?-lyase deficiency protects mice from galactosamine/lipopolysaccharide-induced acute liver failure. Antioxid Redox Signal. 2014 Jan 10; 20(2):204-16. PMID: 23758073.
    Citations: 23     Fields:    Translation:AnimalsCells
  47. Sips PY, Irie T, Zou L, Shinozaki S, Sakai M, Shimizu N, Nguyen R, Stamler JS, Chao W, Kaneki M, Ichinose F. Reduction of cardiomyocyte S-nitrosylation by S-nitrosoglutathione reductase protects against sepsis-induced myocardial depression. Am J Physiol Heart Circ Physiol. 2013 Apr 15; 304(8):H1134-46. PMID: 23417863.
    Citations: 8     Fields:    Translation:AnimalsCells
  48. Ichinose F. Improving outcomes after cardiac arrest using NO inhalation. Trends Cardiovasc Med. 2013 Feb; 23(2):52-8. PMID: 23291033.
    Citations: 2     Fields:    Translation:Animals
  49. Marutani E, Kosugi S, Tokuda K, Khatri A, Nguyen R, Atochin DN, Kida K, Van Leyen K, Arai K, Ichinose F. A novel hydrogen sulfide-releasing N-methyl-D-aspartate receptor antagonist prevents ischemic neuronal death. J Biol Chem. 2012 Sep 14; 287(38):32124-35. PMID: 22815476.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  50. Tokuda K, Kida K, Marutani E, Crimi E, Bougaki M, Khatri A, Kimura H, Ichinose F. Inhaled hydrogen sulfide prevents endotoxin-induced systemic inflammation and improves survival by altering sulfide metabolism in mice. Antioxid Redox Signal. 2012 Jul 01; 17(1):11-21. PMID: 22221071.
    Citations: 45     Fields:    Translation:Animals
  51. Kida K, Minamishima S, Wang H, Ren J, Yigitkanli K, Nozari A, Mandeville JB, Liu PK, Liu CH, Ichinose F. Sodium sulfide prevents water diffusion abnormality in the brain and improves long term outcome after cardiac arrest in mice. Resuscitation. 2012 Oct; 83(10):1292-7. PMID: 22370005.
    Citations: 14     Fields:    Translation:AnimalsCells
  52. Kehr J, Ichinose F, Yoshitake S, Goiny M, Sievertsson T, Nyberg F, Yoshitake T. Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats. Br J Pharmacol. 2011 Dec; 164(8):1949-58. PMID: 21615721.
    Citations: 79     Fields:    Translation:Animals
  53. Xu Z, Dong Y, Wu X, Zhang J, McAuliffe S, Pan C, Zhang Y, Ichinose F, Yue Y, Xie Z. The potential dual effects of anesthetic isoflurane on Aß-induced apoptosis. Curr Alzheimer Res. 2011 Nov; 8(7):741-52. PMID: 21244349.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  54. Francis RC, Vaporidi K, Bloch KD, Ichinose F, Zapol WM. Protective and Detrimental Effects of Sodium Sulfide and Hydrogen Sulfide in Murine Ventilator-induced Lung Injury. Anesthesiology. 2011 Nov; 115(5):1012-21. PMID: 21912243.
    Citations: 24     Fields:    Translation:Animals
  55. Petersen B, Austen KF, Bloch KD, Hotta Y, Ichinose F, Kanaoka Y, Zapol WM. Cysteinyl leukotrienes impair hypoxic pulmonary vasoconstriction in endotoxemic mice. Anesthesiology. 2011 Oct; 115(4):804-11. PMID: 21934409.
    Citations: 2     Fields:    Translation:AnimalsCells
  56. Zhang J, Dong Y, Xu Z, Zhang Y, Pan C, McAuliffe S, Ichinose F, Yue Y, Liang W, Xie Z. 2-Deoxy-D-glucose attenuates isoflurane-induced cytotoxicity in an in vitro cell culture model of H4 human neuroglioma cells. Anesth Analg. 2011 Dec; 113(6):1468-75. PMID: 21965367.
    Citations: 9     Fields:    Translation:HumansCells
  57. Carvalho AR, Ichinose F, Schettino IA, Hess D, Rojas J, Giannella-Neto A, Agnihotri A, Walker J, MacGillivray TE, Vidal Melo MF. Tidal lung recruitment and exhaled nitric oxide during coronary artery bypass grafting in patients with and without chronic obstructive pulmonary disease. Lung. 2011 Dec; 189(6):499-509. PMID: 21952833.
    Citations: 2     Fields:    Translation:Humans
  58. Minamishima S, Kida K, Tokuda K, Wang H, Sips PY, Kosugi S, Mandeville JB, Buys ES, Brouckaert P, Liu PK, Liu CH, Bloch KD, Ichinose F. Inhaled nitric oxide improves outcomes after successful cardiopulmonary resuscitation in mice. Circulation. 2011 Oct 11; 124(15):1645-53. PMID: 21931083.
    Citations: 22     Fields:    Translation:AnimalsCells
  59. Yang W, Yamada M, Tamura Y, Chang K, Mao J, Zou L, Feng Y, Kida K, Scherrer-Crosbie M, Chao W, Ichinose F, Yu YM, Fischman AJ, Tompkins RG, Yao S, Kaneki M. Farnesyltransferase inhibitor FTI-277 reduces mortality of septic mice along with improved bacterial clearance. J Pharmacol Exp Ther. 2011 Dec; 339(3):832-41. PMID: 21873557.
    Citations: 8     Fields:    Translation:AnimalsCells
  60. Kakinohana M, Kida K, Minamishima S, Atochin DN, Huang PL, Kaneki M, Ichinose F. Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice. Stroke. 2011 Aug; 42(8):2302-7. PMID: 21700940.
    Citations: 6     Fields:    Translation:AnimalsCells
  61. Steinbicker AU, Liu H, Jiramongkolchai K, Malhotra R, Choe EY, Busch CJ, Graveline AR, Kao SM, Nagasaka Y, Ichinose F, Buys ES, Brouckaert P, Zapol WM, Bloch KD. Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Nitric Oxide. 2011 Oct 30; 25(3):294-302. PMID: 21642009.
    Citations: 5     Fields:    Translation:AnimalsCells
  62. Cawley SM, Kolodziej S, Ichinose F, Brouckaert P, Buys ES, Bloch KD. sGC{alpha}1 mediates the negative inotropic effects of NO in cardiac myocytes independent of changes in calcium handling. Am J Physiol Heart Circ Physiol. 2011 Jul; 301(1):H157-63. PMID: 21536853.
    Citations: 12     Fields:    Translation:AnimalsCells
  63. Kida K, Yamada M, Tokuda K, Marutani E, Kakinohana M, Kaneki M, Ichinose F. Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease. Antioxid Redox Signal. 2011 Jul 15; 15(2):343-52. PMID: 21050138.
    Citations: 39     Fields:    Translation:AnimalsCells
  64. Sips PY, Brouckaert P, Ichinose F. The alpha1 isoform of soluble guanylate cyclase regulates cardiac contractility but is not required for ischemic preconditioning. Basic Res Cardiol. 2011 Jun; 106(4):635-43. PMID: 21394564.
    Citations: 6     Fields:    Translation:AnimalsCells
  65. de Prost N, El-Karak C, Avila M, Ichinose F, Vidal Melo MF. Changes in cysteinyl leukotrienes during and after cardiac surgery with cardiopulmonary bypass in patients with and without chronic obstructive pulmonary disease. J Thorac Cardiovasc Surg. 2011 Jun; 141(6):1496-502.e3. PMID: 21377695.
    Citations: 4     Fields:    Translation:Humans
  66. Derwall M, Francis RC, Kida K, Bougaki M, Crimi E, Adrie C, Zapol WM, Ichinose F. Administration of hydrogen sulfide via extracorporeal membrane lung ventilation in sheep with partial cardiopulmonary bypass perfusion: a proof of concept study on metabolic and vasomotor effects. Crit Care. 2011; 15(1):R51. PMID: 21299857.
    Citations: 11     Fields:    Translation:Animals
  67. Minamishima S, Ichinose F. [Emerging role of hydrogen sulfide in biology]. Masui. 2010 Nov; 59 Suppl:S42-8. PMID: 21692251.
    Citations:    Fields:    Translation:HumansAnimalsCells
  68. Yamada M, Kida K, Amutuhaire W, Ichinose F, Kaneki M. Gene disruption of caspase-3 prevents MPTP-induced Parkinson's disease in mice. Biochem Biophys Res Commun. 2010 Nov 12; 402(2):312-8. PMID: 20937256.
    Citations: 13     Fields:    Translation:AnimalsCells
  69. Bougaki M, Searles RJ, Kida K, Yu J, Buys ES, Ichinose F. Nos3 protects against systemic inflammation and myocardial dysfunction in murine polymicrobial sepsis. Shock. 2010 Sep; 34(3):281-90. PMID: 19997049.
    Citations: 17     Fields:    Translation:AnimalsCells
  70. Zou L, Feng Y, Chen YJ, Si R, Shen S, Zhou Q, Ichinose F, Scherrer-Crosbie M, Chao W. Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis. Crit Care Med. 2010 May; 38(5):1335-42. PMID: 20228680.
    Citations: 27     Fields:    Translation:AnimalsCells
  71. Minamishima S, Bougaki M, Sips PY, Yu JD, Minamishima YA, Elrod JW, Lefer DJ, Bloch KD, Ichinose F. Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice. Circulation. 2009 Sep 08; 120(10):888-96. PMID: 19704099.
    Citations: 76     Fields:    Translation:AnimalsCells
  72. Buys ES, Cauwels A, Raher MJ, Passeri JJ, Hobai I, Cawley SM, Rauwerdink KM, Thibault H, Sips PY, Thoonen R, Scherrer-Crosbie M, Ichinose F, Brouckaert P, Bloch KD. sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H654-63. PMID: 19502556.
    Citations: 28     Fields:    Translation:AnimalsCells
  73. Nishida T, Yu JD, Minamishima S, Sips PY, Searles RJ, Buys ES, Janssens S, Brouckaert P, Bloch KD, Ichinose F. Protective effects of nitric oxide synthase 3 and soluble guanylate cyclase on the outcome of cardiac arrest and cardiopulmonary resuscitation in mice. Crit Care Med. 2009 Jan; 37(1):256-62. PMID: 19050616.
    Citations: 11     Fields:    Translation:Animals
  74. Nagasaka Y, Fernandez BO, Garcia-Saura MF, Petersen B, Ichinose F, Bloch KD, Feelisch M, Zapol WM. Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. Anesthesiology. 2008 Oct; 109(4):675-82. PMID: 18813047.
    Citations: 31     Fields:    Translation:AnimalsCells
  75. Derumeaux G, Ichinose F, Raher MJ, Morgan JG, Coman T, Lee C, Cuesta JM, Thibault H, Bloch KD, Picard MH, Scherrer-Crosbie M. Myocardial alterations in senescent mice and effect of exercise training: a strain rate imaging study. Circ Cardiovasc Imaging. 2008 Nov; 1(3):227-34. PMID: 19808547.
    Citations: 10     Fields:    Translation:Animals
  76. Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci. 2008 Apr 23; 28(17):4551-60. PMID: 18434534.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  77. Yu B, Raher MJ, Volpato GP, Bloch KD, Ichinose F, Zapol WM. Inhaled nitric oxide enables artificial blood transfusion without hypertension. Circulation. 2008 Apr 15; 117(15):1982-90. PMID: 18391111.
    Citations: 42     Fields:    Translation:Animals
  78. Volpato GP, Searles R, Yu B, Scherrer-Crosbie M, Bloch KD, Ichinose F, Zapol WM. Inhaled hydrogen sulfide: a rapidly reversible inhibitor of cardiac and metabolic function in the mouse. Anesthesiology. 2008 Apr; 108(4):659-68. PMID: 18362598.
    Citations: 34     Fields:    Translation:Animals
  79. Buys ES, Sips P, Vermeersch P, Raher MJ, Rogge E, Ichinose F, Dewerchin M, Bloch KD, Janssens S, Brouckaert P. Gender-specific hypertension and responsiveness to nitric oxide in sGCalpha1 knockout mice. Cardiovasc Res. 2008 Jul 01; 79(1):179-86. PMID: 18339647.
    Citations: 48     Fields:    Translation:AnimalsCells
  80. Ichinose F. [Impact of nitric oxide synthase 3 on myocardial dysfunction in sepsis]. Masui. 2008 Mar; 57(3):294-301. PMID: 18340997.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  81. Petersen B, Bloch KD, Ichinose F, Shin HS, Shigematsu M, Bagchi A, Zapol WM, Hellman J. Activation of Toll-like receptor 2 impairs hypoxic pulmonary vasoconstriction in mice. Am J Physiol Lung Cell Mol Physiol. 2008 Feb; 294(2):L300-8. PMID: 18055842.
    Citations: 8     Fields:    Translation:AnimalsCells
  82. Liu R, Hotta Y, Graveline AR, Evgenov OV, Buys ES, Bloch KD, Ichinose F, Zapol WM. Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2007 Nov; 293(5):L1300-5. PMID: 17720871.
    Citations: 2     Fields:    Translation:Animals
  83. Raher MJ, Thibault H, Poh KK, Liu R, Halpern EF, Derumeaux G, Ichinose F, Zapol WM, Bloch KD, Picard MH, Scherrer-Crosbie M. In vivo characterization of murine myocardial perfusion with myocardial contrast echocardiography: validation and application in nitric oxide synthase 3 deficient mice. Circulation. 2007 Sep 11; 116(11):1250-7. PMID: 17709634.
    Citations: 19     Fields:    Translation:Animals
  84. Vermeersch P, Buys E, Pokreisz P, Marsboom G, Ichinose F, Sips P, Pellens M, Gillijns H, Swinnen M, Graveline A, Collen D, Dewerchin M, Brouckaert P, Bloch KD, Janssens S. Soluble guanylate cyclase-alpha1 deficiency selectively inhibits the pulmonary vasodilator response to nitric oxide and increases the pulmonary vascular remodeling response to chronic hypoxia. Circulation. 2007 Aug 21; 116(8):936-43. PMID: 17679618.
    Citations: 22     Fields:    Translation:AnimalsCells
  85. Neilan TG, Blake SL, Ichinose F, Raher MJ, Buys ES, Jassal DS, Furutani E, Perez-Sanz TM, Graveline A, Janssens SP, Picard MH, Scherrer-Crosbie M, Bloch KD. Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin. Circulation. 2007 Jul 31; 116(5):506-14. PMID: 17638931.
    Citations: 35     Fields:    Translation:AnimalsCells
  86. Bloch KD, Ichinose F, Roberts JD, Zapol WM. Inhaled NO as a therapeutic agent. Cardiovasc Res. 2007 Jul 15; 75(2):339-48. PMID: 17544387.
    Citations: 35     Fields:    Translation:HumansAnimals
  87. Buys ES, Raher MJ, Blake SL, Neilan TG, Graveline AR, Passeri JJ, Llano M, Perez-Sanz TM, Ichinose F, Janssens S, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Cardiomyocyte-restricted restoration of nitric oxide synthase 3 attenuates left ventricular remodeling after chronic pressure overload. Am J Physiol Heart Circ Physiol. 2007 Jul; 293(1):H620-7. PMID: 17416602.
    Citations: 32     Fields:    Translation:AnimalsCells
  88. Ben Harder. Perchance to hibernate. Science News. 2007; 171(4):56-58 .
  89. Ichinose F, Buys ES, Neilan TG, Furutani EM, Morgan JG, Jassal DS, Graveline AR, Searles RJ, Lim CC, Kaneki M, Picard MH, Scherrer-Crosbie M, Janssens S, Liao R, Bloch KD. Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res. 2007 Jan 05; 100(1):130-9. PMID: 17138944.
    Citations: 37     Fields:    Translation:AnimalsCells
  90. Ichinose F. [Septic shock and NO]. Masui. 2006 Nov; 55 Suppl:S18-23. PMID: 17458113.
    Citations:    Fields:    Translation:HumansAnimalsCells
  91. Neilan TG, Jassal DS, Perez-Sanz TM, Raher MJ, Pradhan AD, Buys ES, Ichinose F, Bayne DB, Halpern EF, Weyman AE, Derumeaux G, Bloch KD, Picard MH, Scherrer-Crosbie M. Tissue Doppler imaging predicts left ventricular dysfunction and mortality in a murine model of cardiac injury. Eur Heart J. 2006 Aug; 27(15):1868-75. PMID: 16717080.
    Citations: 31     Fields:    Translation:Animals
  92. Hataishi R, Rodrigues AC, Morgan JG, Ichinose F, Derumeaux G, Bloch KD, Picard MH, Scherrer-Crosbie M. Nitric oxide synthase 2 and pressure-overload-induced left ventricular remodelling in mice. Exp Physiol. 2006 May; 91(3):633-9. PMID: 16527862.
    Citations: 5     Fields:    Translation:Animals
  93. Hataishi R, Rodrigues AC, Neilan TG, Morgan JG, Buys E, Shiva S, Tambouret R, Jassal DS, Raher MJ, Furutani E, Ichinose F, Gladwin MT, Rosenzweig A, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide decreases infarction size and improves left ventricular function in a murine model of myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2006 Jul; 291(1):H379-84. PMID: 16443673.
    Citations: 46     Fields:    Translation:Animals
  94. Gas induces 'suspended animation’. BBC NEWS. 2006.
  95. Buys ES, Raher MJ, Passeri JJ, Ichinose F, Picard MH, Sips PY, Brouckaert P, Scherrer-Crosbie M, Bloch KD. Hypertension and Cardiac Dysfunction in Male Mice Deficient in the Alpha 1 Subunit of Soluble Guanylate Cyclase. Circulation. 2006; 114:641.
  96. David Biello. Sewer Gas Sends Mice into Suspended Animation. Scientific American.com. 2006.
  97. Vidal Melo MF, Ichinose F, Walker JD, MacGillivray TE, Hess D. Intraoperative Changes in Respiratory Function during On-Pump CABG in COPD Patients. Anesthesiology. 2006; 105:A1221.
  98. Susan Nasr. Swamp Gas for Safer Surgery - Hydrogen sulfide gas could give surgeons a little extra time to perform rare heart surgeries. Technology Review. 2006.
  99. Roxanne Khamsi. Rotten egg' gas puts mice in suspended animation. NewScientist.com. 2006.
  100. Ichinose F, Buys ES, Neilan TG, Scherrer-Crosbie M, Bloch KD. Cardiomyocyte-Specific Overexpression of eNOS Prevents Myocardial Dysfunction in Murine Sepsis. Anesthesiology. 2006; 105:A764.
  101. Nishida T, Searles RJ, Shigematsu M, Janssens S, Bloch KD, Ichinose F. Cardiac-Specific NOS3 Overexpression Rescues Myocardial and Neuronal Function after Cardiopulmonary Resuscitation in NOS3-Deficient Mice. Circulation. 2006; 114:75.
  102. Volpato G, Searles RJ, Scherrer-Crosbie M, Bloch KD, Ichinose F, W.M. Zapol. Cardiovascular Changes after Exposure to Hydrogen Sulfide in a Murine Model. Circulation. 2006; 114:2273.
  103. Nishida T, Searles RJ, Shigematsu M, Buys ES, Janssens S, Bloch KD, Ichinose F. eNOS Deficiency Worsens Neurological and Myocardial Function after Cardiac Arrest and CPR in Mouse. Anesthesiology. 2006; 105:A1730.
  104. Yu PB, Deng DY, Beppu H, Kawai N, Ichinose F, Bloch KD. Bone Morphogenetic Protein (BMP) Type II Receptor, but Not Activin Type II Receptor, Mediates the Anti-Proliferative Effects of BMPs in Pulmonary Artery Smooth Muscle Cells. Circulation. 2006; 114:523.
  105. Hataishi R, Zapol WM, Bloch KD, Ichinose F. Inhaled nitric oxide does not reduce systemic vascular resistance in mice. Am J Physiol Heart Circ Physiol. 2006 May; 290(5):H1826-9. PMID: 16299267.
    Citations: 5     Fields:    Translation:Animals
  106. Evgenov OV, Busch CJ, Evgenov NV, Liu R, Petersen B, Falkowski GE, Petho B, Vas A, Bloch KD, Zapol WM, Ichinose F. Inhibition of phosphodiesterase 1 augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs with acute pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2006 Apr; 290(4):L723-L729. PMID: 16284211.
    Citations: 10     Fields:    Translation:Animals
  107. Bloch KD, Ichinose F, Zapol WM. INO Therapeutics assignee. Enhancing therapeutic effectiveness of nitric oxide inhalation. 2005.
  108. Sebag IA, Handschumacher MD, Ichinose F, Morgan JG, Hataishi R, Rodrigues AC, Guerrero JL, Steudel W, Raher MJ, Halpern EF, Derumeaux G, Bloch KD, Picard MH, Scherrer-Crosbie M. Quantitative assessment of regional myocardial function in mice by tissue Doppler imaging: comparison with hemodynamics and sonomicrometry. Circulation. 2005 May 24; 111(20):2611-6. PMID: 15897347.
    Citations: 20     Fields:    Translation:Animals
  109. Caironi P, Ichinose F, Liu R, Jones RC, Bloch KD, Zapol WM. 5-Lipoxygenase deficiency prevents respiratory failure during ventilator-induced lung injury. Am J Respir Crit Care Med. 2005 Aug 01; 172(3):334-43. PMID: 15894604.
    Citations: 17     Fields:    Translation:Animals
  110. Zhu X, Bernecker OY, Manohar NS, Hajjar RJ, Hellman J, Ichinose F, Valdivia HH, Schmidt U. Increased leakage of sarcoplasmic reticulum Ca2+ contributes to abnormal myocyte Ca2+ handling and shortening in sepsis. Crit Care Med. 2005 Mar; 33(3):598-604. PMID: 15753753.
    Citations: 21     Fields:    Translation:AnimalsCells
  111. Ichinose F, Buys ES, Lim CC, Janssens S, Liao R, Bloch KD. Cardiac-Specific Overexpression of NO Synthase 3 (NOS3) Attenuates Production of Reactive Oxygen Species and Preserves Cardiac Myocyte Contractile Function During Endotoxemia. Circulation. 2005; 112:1358.
  112. Ichinose F. Diagnosis and management of pulmonary hypertension. In: Takeda J and Morita S, editors. Progress in Cardiovascular Anesthesia. 2005; 296-303.
  113. Jassal DS, Buys E, Neilan TG, Raher MJ, Ichinose F, Janssens S, Picard MH, Bloch KD, Scherrer-Crosbie M. Jassal DS, Buys E, Neilan TG, Raher MJ, Ichinose F, Janssens S, Picard MH, Bloch KD, Scherrer-Crosbie M. Circulation. 2005; 112:852.
  114. Raher MJ, Thibault H, Liu R, Hataishi R, Derumeaux G, Bloch KD, Ichinose F, Picard MH, Scherrer-Crosbie M. Impaired Coronary Artery Reserve in Nitric Oxide Synthase 3 Deficient Mice: A Myocardial Contrast Echocardiography Study. Circulation. 2005; 112:3131.
  115. Buys E, Ichinose F, Morgan JG, Scherrer-Crosbie M, Bloch KD. Buys E, Ichinose F, Morgan JG, Scherrer-Crosbie M, Bloch KD. BMC Pharmacology. 2005; suppl 1:P7.
  116. Neilan TG, Jassal DS, Buys ES, Raher MJ, Ichinose F, Perez-Sanz TM, Bayne DB, Graveline A, Janssens S, Picard MH, Scherrer-Crosbie M, Bloch KD. Endothelial Nitric Oxide Synthase Augments Anthracycline-Induced Cardiac Injury. Circulation. 2005; 112:486.
  117. Ichinose F. Inhaled nitric oxide. Masui. 2005; 54:S14-S19.
  118. Liu R, Evgenov OV, Ichinose F. Nitric oxide synthase 3 deficiency augments hypoxic pulmonary vasoconstriction and systemic oxygenation during one-lung ventilation in mice. J Appl Physiol. 2005; 98:748-752.
  119. Vermeersch P, Pokreisz P, Marsboom G, Buys ES, Gillijns H, Pellens M, Swinnen M, Ichinose F, Dewerchin M, Brouckaert P, Bloch K, Janssens S. Soluble Guanylate Cyclase Deficiency Selectively Abolishes NO-Mediated Pulmonary Vasodilation and Increases the Pulmonary Vascular Remodeling Response to Chronic Hypoxia. Circulation. 2005; 112:1146.
  120. Goto T, Hanne P, Ishiguro Y, Ichinose F, Niimi Y, Morita S. Cardiovascular effects of xenon and nitrous oxide in patients during fentanyl-midazolam anaesthesia. Anaesthesia. 2004 Dec; 59(12):1178-83. PMID: 15549976.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  121. Evgenov OV, Ichinose F, Evgenov NV, Gnoth MJ, Falkowski GE, Chang Y, Bloch KD, Zapol WM. Soluble guanylate cyclase activator reverses acute pulmonary hypertension and augments the pulmonary vasodilator response to inhaled nitric oxide in awake lambs. Circulation. 2004 Oct 12; 110(15):2253-9. PMID: 15466650.
    Citations: 24     Fields:    Translation:Animals
  122. Liu R, Evgenov OV, Ichinose F. NOS3 deficiency augments hypoxic pulmonary vasoconstriction and enhances systemic oxygenation during one-lung ventilation in mice. J Appl Physiol (1985). 2005 Feb; 98(2):748-52. PMID: 15465885.
    Citations: 4     Fields:    Translation:Animals
  123. Rodrigues AC, Hataishi R, Ichinose F, Bloch KD, Derumeaux G, Picard MH, Scherrer-Crosbie M. Relationship of systolic dysfunction to area at risk and infarction size after ischemia-reperfusion in mice. J Am Soc Echocardiogr. 2004 Sep; 17(9):948-53. PMID: 15337959.
    Citations: 5     Fields:    Translation:Animals
  124. Beppu H, Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD. BMPR-II heterozygous mice have mild pulmonary hypertension and an impaired pulmonary vascular remodeling response to prolonged hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004 Dec; 287(6):L1241-7. PMID: 15286002.
    Citations: 59     Fields:    Translation:Animals
  125. Ichinose F, Roberts JD, Zapol WM. Inhaled nitric oxide: a selective pulmonary vasodilator: current uses and therapeutic potential. Circulation. 2004 Jun 29; 109(25):3106-11. PMID: 15226227.
    Citations: 42     Fields:    Translation:Humans
  126. Beppu H, * Ichinose F, Kawai N, Jones RC, Yu PB, Zapol WM, Miyazono K, Li E, Bloch KD. The Heterozygous Mutant Mice for BMP Type II Receptor Gene Have Mild Pulmonary Hypertension and Impaired Response to Chronic Hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004; 287(6):L1241-L1247.
  127. Hataishi R, Zapol WM, Bloch KD, Ichinose F. Regional redistribution of blood flow during nitric oxide inhalation in mice deficient for NOS3. Am J Resp Crit Care Med. 2004; 169(7):A396.
  128. Ichinose F, Morgan JG, Buys E, Scherrer-Crosbie M, Janssens S, Bloch KD. Cardiomyocyte-restricted overexpression of NOS3 prevents endotoxin-induced myocardial dysfunction in mice. Circulation. 2004; 110:1600.
  129. Ichinose F, Roberts JD, Zapol WM. Inhaled Nitric Oxide: A Selective Pulmonary Vasodilator - Current uses and therapeutic potential. 2004; 109:3106-3111.
  130. Ichinose F, Bloch KD, Wu JC, Hataishi R, Aretz HT, Picard MH, Scherrer-Crosbie M. Pressure-Overload Induced Left Ventricular Hypertrophy and Dysfunction are Exacerbated by Nitric Oxide Synthase 3 Deficiency in Mice. Am J Physiol Heart Circ Physiol. 2004; 286:H1070-H1075.
  131. Kawakami H, Ichinose F. Inhaled Nitric Oxide in Pediatric Cardiac Surgery. In: Qu J, editor. Pediatric Cardiac Anesthesia. Int Anesthesiol Clin. 2004; 42(4):93-100.
  132. Rojas J, Ichinose F, MacGillivray T, Walker J, Agnihotri A, Hess D, Vidal Melo M. Exhaled nitric oxide is reduced after coronary artery bypass surgery in patients with chronic obstructive pulmonary disease. Anesth Analg. 2004; 98:SCA 1-134.
  133. Hataishi R, Morgan JG, Rodorigues ACT, Ichinose F, Zapol WM, Picard MH, Bloch KD, Scherrer-Crosbie M. Inhaled nitric oxide limits murine ischemia-reperfusion injury. Circulation. 2004; 110:234.
  134. Kawakami H, Ichinose F. Inhaled nitric oxide in pediatric cardiac surgery. Int Anesthesiol Clin. 2004; 42(4):93-100. PMID: 15577703.
    Citations: 1     Fields:    Translation:Humans
  135. Derumeaux G, Morgan JG, Coman T, Cuesta JM, Lee C, Rodorigues ACT, Thibault H, Raher MJ, Hataishi R, Buys E, Bloch KD, Ichinose F, Scherrer-Crosbie M. Exercise training attenuates aging-related left ventricular systolic dysfunction in mice: a strain-rate study. Circulation. 2004; 110:3313.
  136. Ichinose F, Bloch KD, Wu JC, Hataishi R, Aretz HT, Picard MH, Scherrer-Crosbie M. Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency. Am J Physiol Heart Circ Physiol. 2004 Mar; 286(3):H1070-5. PMID: 14644766.
    Citations: 38     Fields:    Translation:AnimalsCells
  137. Ichinose F, Hataishi R, Wu JC, Kawai N, Rodrigues AC, Mallari C, Post JM, Parkinson JF, Picard MH, Bloch KD, Zapol WM. A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice. Am J Physiol Heart Circ Physiol. 2003 Dec; 285(6):H2524-30. PMID: 12907425.
    Citations: 17     Fields:    Translation:AnimalsCells
  138. Bloch KD, Ichinose F, Zapol WM. INO Therapeutics assignee. Enhancing therapeutic effectiveness of nitric oxide inhalation. 2003.
  139. Liu H, Choe EY, Ichinose F, Busch CJ, Panella SM, Bloch KD. Nitric Oxide Stimulates Inducible cAMP Early Repressor (ICER) Gene Expression in Rat Pulmonary Artery Smooth Muscle Cells. Circulation. 2003; 108:575.
  140. Baboolal HA, Ichinose F, Ullrich R, Kawai N, Bloch KD, Zapol WM. Reactive oxygen species scavengers attenuate endotoxin-induced impairment of hypoxic pulmonary vasoconstriction in mice. Anesthesiology. 2002 Nov; 97(5):1227-33. PMID: 12411809.
    Citations: 9     Fields:    Translation:Animals
  141. Ichinose F, Ullrich R, Sapirstein A, Jones RC, Bonventre JV, Serhan CN, Bloch KD, Zapol WM. Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction. J Clin Invest. 2002 Jun; 109(11):1493-500. PMID: 12045263.
    Citations: 20     Fields:    Translation:AnimalsCells
  142. Raveh Y, Ichinose F, Orbach P, Bloch KD, Zapol WM. Radical scavengers protect murine lungs from endotoxin-induced hyporesponsiveness to inhaled nitric oxide. Anesthesiology. 2002 Apr; 96(4):926-33. PMID: 11964601.
    Citations:    Fields:    Translation:Animals
  143. Caironi P, Ichinose F, Taccone P, Kawai N, Zapol WM. Large Tidal Volume Ventilation Affects Respiratory Mechanics and Pulmonary TNFa Expression in an In Vivo Mouse Model. Anesthesiology. 2002; 96:A327.
  144. Ichinose F, Erana-Garcia J, Hromi J, Raveh Y, Jones R, Krim L, Clark MW, Winkler JD, Bloch KD, Zapol WM. Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension. Crit Care Med. 2001 May; 29(5):1000-5. PMID: 11378612.
    Citations: 18     Fields:    Translation:Animals
  145. Ichinose F, Zapol WM, Sapirstein A, Ullrich R, Tager AM, Coggins K, Jones R, Bloch KD. Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice. Circ Res. 2001 Apr 27; 88(8):832-8. PMID: 11325876.
    Citations: 12     Fields:    Translation:Animals
  146. Takata M, Filippov G, Liu H, Ichinose F, Janssens S, Bloch DB, Bloch KD. Cytokines decrease sGC in pulmonary artery smooth muscle cells via NO-dependent and NO-independent mechanisms. Am J Physiol Lung Cell Mol Physiol. 2001 Feb; 280(2):L272-8. PMID: 11159006.
    Citations: 14     Fields:    Translation:AnimalsCells
  147. Ullrich R, Scherrer-Crosbie M, Bloch KD, Ichinose F, Nakajima H, Picard MH, Zapol WM, Quezado ZM. Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice. Circulation. 2000 Sep 19; 102(12):1440-6. PMID: 10993865.
    Citations: 28     Fields:    Translation:Animals
  148. Uezono S, Goto T, Terui K, Ichinose F, Ishguro Y, Nakata Y, Morita S. Emergence agitation after sevoflurane versus propofol in pediatric patients. Anesth Analg. 2000 Sep; 91(3):563-6. PMID: 10960377.
    Citations: 36     Fields:    Translation:HumansCTClinical Trials
  149. Ichinose F, Niimi Y, Nomura M . Cardiomyopathy. In: Recent Advances in Transesophageal Doppler Echocardiography, Ryozo Omoto and Yasu Oka, editors. 2000.
  150. Ullrich R, Bloch KD, Ichinose F, Steudel W, Zapol WM. Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest. 1999 Nov; 104(10):1421-9. PMID: 10562304.
    Citations: 15     Fields:    Translation:AnimalsCells
  151. Yamano S, Ichinose F, Todaka T, Toki S. Purification and characterization of two major forms of naloxone reductase from rabbit liver cytosol, new members of aldo-keto reductase superfamily. Biol Pharm Bull. 1999 Oct; 22(10):1038-46. PMID: 10549852.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  152. Niimi Y, Ichinose F, Ishiguro Y, Terui K, Uezono S, Morita S, Yamane S. The effects of heparin coating of oxygenator fibers on platelet adhesion and protein adsorption. Anesth Analg. 1999 Sep; 89(3):573-9. PMID: 10475283.
    Citations: 6     Fields:    Translation:HumansCells
  153. Ichinose F, Miyazaki M, Goto T, Takahashi H, Terui K, Niimi Y, Uezono S, Morita S, Yanagida H. Electroencephalographic responses to the formalin test in rats. Pain. 1999 Mar; 80(1-2):251-6. PMID: 10204737.
    Citations: 2     Fields:    Translation:Animals
  154. Goto T, Saito H, Nakata Y, Uezono S, Ichinose F, Uchiyama M, Morita S. Effects of xenon on the performance of various respiratory flowmeters. Anesthesiology. 1999 Feb; 90(2):555-63. PMID: 9952164.
    Citations: 1     Fields:    Translation:Humans
  155. Ichinose F, Uezono S, Muto R, Uchida H, Hatori F, Terui K, Niimi Y, Goto T, Nakata Y, Morita S. Platelet hyporeactivity in young infants during cardiopulmonary bypass. Anesth Analg. 1999 Feb; 88(2):258-62. PMID: 9972737.
    Citations: 2     Fields:    Translation:HumansCells
  156. Uezono S, Miyazaki M, Ichinose F, Goto T, Morita S. Nitric oxide attenuates endotoxin-induced ICAM-1 on pulmonary vascular endothelial cells: role of nuclear factor NF-kB. Anesthesiology. 1999; 91:A1390.
  157. Uezono S, Miyazaki M, Ichinose F, Goto T, Morita S. The effects of endothelin-1 on cell adhesion molecules (CAMs) on cultured human vascular endothelial cells (VECS). Anesthesiology. 1999; 91:A275.
  158. Mi WD, Ichinose F, Goto T, Niimi Y, Uchiyama M, Morita S. 7-Nitroindazole, a selective inhibitor of neuronal nitric oxide synthase: effect on sevoflurane MAC and cerebellar cyclic GMP in mice. J Anesth. 1998 Sep; 12(3):137-141. PMID: 28921181.
    Citations:    Fields:    
  159. Ichinose F, Mi WD, Miyazaki M, Onouchi T, Goto T, Morita S. Lack of correlation between the reduction of sevoflurane MAC and the cerebellar cyclic GMP concentrations in mice treated with 7-nitroindazole. Anesthesiology. 1998 Jul; 89(1):143-8. PMID: 9667304.
    Citations: 7     Fields:    Translation:Animals
  160. Nakata Y, Goto T, Saito H, Ichinose F, Uezono S, Morita S. The placement of the cuffed oropharyngeal airway with sevoflurane in adults: a comparison with the laryngeal mask airway. Anesth Analg. 1998 Jul; 87(1):143-6. PMID: 9661563.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  161. Uezono S, Goto T, Nakata Y, Ichinose F, Niimi Y, Morita S. The cuffed oropharyngeal airway, a novel adjunct to the management of difficult airways. Anesthesiology. 1998 Jun; 88(6):1677-9. PMID: 9637666.
    Citations: 1     Fields:    Translation:Humans
  162. Nakata Y, Goto T, Saito H, Ichinose F, Uezono S, Suwa K, Morita S. Comparison of acceleromyography and electromyography in vecuronium-induced neuromuscular blockade with xenon or sevoflurane anesthesia. J Clin Anesth. 1998 May; 10(3):200-3. PMID: 9603589.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  163. Goto T, Suwa K, Uezono S, Ichinose F, Uchiyama M, Morita S. The blood-gas partition coefficient of xenon may be lower than generally accepted. Br J Anaesth. 1998 Feb; 80(2):255-6. PMID: 9602599.
    Citations: 23     Fields:    Translation:Humans
  164. Adrie C, Ichinose F, Holzmann A, Keefer L, Hurford WE, Zapol WM. Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension. J Appl Physiol (1985). 1998 Feb; 84(2):435-41. PMID: 9475849.
    Citations: 6     Fields:    Translation:Animals
  165. Ichinose F, Adrie C, Hurford WE, Bloch KD, Zapol WM. Selective pulmonary vasodilation induced by aerosolized zaprinast. Anesthesiology. 1998 Feb; 88(2):410-6. PMID: 9477062.
    Citations: 4     Fields:    Translation:Animals
  166. Mi W-d, Ichinose F, Goto T, Niimi Y, Uchiyama M, Morita S. 7-Nitroindazole, a selective inhibitor of neuronal nitric oxide synthase: effect on sevoflurane MAC and cerebellar cyclic GMP in mice. J Anesth. 1998; 12:137-141.
  167. Goto T, Saito H, Nakata Y, Uezono S, Ichinose F, Morita S. Emergence times from xenon anaesthesia are independent of the duration of anaesthesia. Br J Anaesth. 1997 Nov; 79(5):595-9. PMID: 9422897.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  168. Steudel W, Ichinose F, Huang PL, Hurford WE, Jones RC, Bevan JA, Fishman MC, Zapol WM. Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ Res. 1997 Jul; 81(1):34-41. PMID: 9201025.
    Citations: 50     Fields:    Translation:Animals
  169. Goto T, Saito H, Shinkai M, Nakata Y, Ichinose F, Morita S. Xenon provides faster emergence from anesthesia than does nitrous oxide-sevoflurane or nitrous oxide-isoflurane. Anesthesiology. 1997 Jun; 86(6):1273-8. PMID: 9197295.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  170. Niimi Y, Ichinose F, Saegusa H, Nakata Y, Morita S. Echocardiographic evaluation of global left ventricular function during high thoracic epidural anesthesia. J Clin Anesth. 1997 Mar; 9(2):118-24. PMID: 9075036.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  171. Ichinose F, Conlay LA . Cholelithiasis. In: Roisen MF, Fleisher LA, editors. Essence of Anesthesia Practice. 1997; 77.
  172. Ichinose F, Morita S . Anesthetic management of patients with cardiac failure. In: Yazaki Y, editor. Treatment of Cardiac Failure. 1997; 605-612.
  173. Ichinose F, Hurford WE, Zapol WM. Inhaled NO in ARDS and Lung Injury Models. In: Nitric Oxide and the Lung, Warren M. Zapol and Kenneth D. Bloch, editors. 1997; 251-270.
  174. Niimi Y, Morita S, Watanabe T, Yamamoto S, Rubsamen R, Ichinose F. Effects of nitroglycerin infusion on segmental wall motion abnormalities after anesthetic induction. J Cardiothorac Vasc Anesth. 1996 Oct; 10(6):734-40. PMID: 8910152.
    Citations:    Fields:    Translation:Humans
  175. Ichinose F, Huang PL, Zapol WM. Effects of targeted neuronal nitric oxide synthase gene disruption and nitroG-L-arginine methylester on the threshold for isoflurane anesthesia. Anesthesiology. 1995 Jul; 83(1):101-8. PMID: 7541615.
    Citations: 9     Fields:    Translation:AnimalsCells
  176. Ichinose F, Adrie C, Hurford WE, Zapol WM. Prolonged pulmonary vasodilator action of inhaled nitric oxide by Zaprinast in awake lambs. J Appl Physiol (1985). 1995 Apr; 78(4):1288-95. PMID: 7615435.
    Citations: 3     Fields:    Translation:Animals
  177. Ichinose F, Adrie C, Hurford W.E., Zapol W.M. Prolonged duration of action of inhaled nitric oxide by the cGMP phosphodiesterase inhibitor Zaprinast in awake lambs. J Appl Physiol. 1995; 78(4):1288-1295.
  178. Husain M, Adrie C, Ichinose F, Kavosi M, Zapol WM. Exhaled nitric oxide as a marker for organic nitrate tolerance. Circulation. 1994 Jun; 89(6):2498-502. PMID: 8205655.
    Citations: 4     Fields:    Translation:Animals
  179. Ichinose F, Morita S. High-dose opioid anesthesia. In: Inada Y, editor. Anesthesia Today. 1993; 4-10.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.